Veterinary Quarterly最新文献_第5页

Global foot-and-mouth disease risk assessment based on multiple spatial analysis and ecological niche model. 基于多空间分析和生态位模型的全球口蹄疫风险评估

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/01652176.2025.2454482

Qi An, Yiyang Lv, Yuepeng Li, Zhuo Sun, Xiang Gao, Hongbin Wang

{"title":"Global foot-and-mouth disease risk assessment based on multiple spatial analysis and ecological niche model.","authors":"Qi An, Yiyang Lv, Yuepeng Li, Zhuo Sun, Xiang Gao, Hongbin Wang","doi":"10.1080/01652176.2025.2454482","DOIUrl":"10.1080/01652176.2025.2454482","url":null,"abstract":"Foot-and-Mouth Disease is a highly contagious transboundary animal disease. FMD has caused a significant economic impact globally due to direct losses and trade restrictions on animals and animal products. This study utilized multi-distance spatial cluster analysis, kernel density analysis, directional distribution analysis to investigate the spatial distribution patterns of historical FMD epidemics. A multi-algorithm ensemble model considering climatic, geographic, and social factors was developed to predict the suitability area for FMDV, and then risk maps of FMD for each species of livestock were generated in combination with the distribution of livestock. The results show that all serotypes of FMD exhibit significant clustering with a clear tendency toward a directional distribution. Serotypes A and O are widespread in Asia, Europe, Africa, and South America. Serotype Asia 1 is prevalent in Asia. Serotype SAT2 is prevalent in Africa and the Middle East, while Serotypes SAT1 and SAT3 are restricted to Africa. Ecological niche modeling reveals temperature, precipitation, wind speed, and vegetation are important factors influencing the occurrence of FMD. Except for buffaloes, the distribution of high-risk areas for FMD occurrence in other livestock species is quite widespread. The areas primarily include the southern region of North America, the northern, southern, and eastern regions of South America, the Mediterranean region, the eastern region of Europe, the central and southern regions of Africa, the central, eastern, and southern regions of Asia, and parts of Australia. These findings will provide valuable insights into the prevention and control of FMD.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-11"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferroptosis in veterinary medicine: mechanisms, therapies, and unmet challenges. 动物医学中的上睑下垂：机制、治疗和未解决的挑战。

IF 5.2 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1080/01652176.2025.2569558

Mohammed Zayed, Mohamed Abdelrazek, Byung-Hoon Jeong

{"title":"Ferroptosis in veterinary medicine: mechanisms, therapies, and unmet challenges.","authors":"Mohammed Zayed, Mohamed Abdelrazek, Byung-Hoon Jeong","doi":"10.1080/01652176.2025.2569558","DOIUrl":"10.1080/01652176.2025.2569558","url":null,"abstract":"Ferroptosis, a regulated cell death, has emerged as a critical contributor to various pathological conditions in animals, particularly infectious, reproductive, musculoskeletal, and nutritional diseases. Ferroptosis differs from apoptosis, necrosis, and other types of cell death, being characterized by the production of reactive oxygen species and excessive lipid peroxidation. Research indicates a close interplay between oxidative stress and ferroptosis in veterinary contexts, where pathogens may manipulate ferroptosis to alter host immune responses, underlining its role in disease progression and defence mechanisms. Key regulators such as SLC7A11, ACSL4, and FSP1 have also been implicated in ferroptosis-related pathophysiology across animal species. Nutritional deficiencies, such as selenium deficiency, impair the activity of GPX4, a key antioxidant enzyme that suppresses ferroptotic pathways. Several therapeutic strategies, such as antioxidants, ferroptosis inhibitors, nutritional supplements, and iron chelators, are currently being explored in veterinary medicine, requiring tailored approaches due to metabolic differences among species. Despite increasing attention in human medicine, ferroptosis remains poorly understood in animal health. Therefore, this review consolidates current knowledge on ferroptosis in veterinary medicine and explores its mechanistic contribution to the pathogenesis of animal diseases. We highlight the emerging strategies for therapeutic intervention and improved animal health outcomes.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"2569558"},"PeriodicalIF":5.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First assessment of the prevalence of Trichinella in backyard-raised pigs in Central-Southern Chile. 智利中南部后院饲养的猪中旋毛虫流行率的首次评估。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/01652176.2025.2475986

Javiera Guzmán-Faúndez, Vanesa Crisóstomo-Jorquera, Carlos Landaeta-Aqueveque, AnaLía Henríquez

{"title":"First assessment of the prevalence of Trichinella in backyard-raised pigs in Central-Southern Chile.","authors":"Javiera Guzmán-Faúndez, Vanesa Crisóstomo-Jorquera, Carlos Landaeta-Aqueveque, AnaLía Henríquez","doi":"10.1080/01652176.2025.2475986","DOIUrl":"10.1080/01652176.2025.2475986","url":null,"abstract":"Trichinellosis is a significant zoonotic disease worldwide, with pigs as a primary reservoir host of human infection. Backyard pigs are particularly at risk due to their exposure to muscle tissue containing Trichinella larvae from synanthropic micromammals or home slaughter waste. In Chile, veterinary inspections of domestically slaughtered pigs are mainly conducted in veterinary clinics using muscle samples provided by farmers or consumers. While positive cases must be reported to the authorities, negative cases are not, creating a gap in official data on Trichinella prevalence. This study aimed to assess the prevalence of Trichinella sp. in backyard and intensively raised pigs in south-central Chile. Records of 2,608 backyard pigs were obtained from various veterinary clinics in the La Araucanía and Ñuble regions, with a few records from the El Maule and Biobío regions, encompassing a total of 33 communes. The overall prevalence was found to be 0.9% (95% confidence interval: 0.59-1.37). According to the available information, records of more than 50,000 pigs slaughtered in abattoirs per year corresponded to negative results after examination. Previous reports suggest that eradication is challenging; however, the decreasing incidence rate of human infection indicates the possibility of improving control measures for this zoonosis.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-7"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function. 探索艾美耳球虫感染与宿主之间的相互作用：了解肠道屏障功能的动态。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-01-20 DOI: 10.1080/01652176.2025.2452169

Pan Chen, Mujeeb Ur Rehman, Yanfeng He, Aoyun Li, Fuchun Jian, Longxian Zhang, Shucheng Huang

{"title":"Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function.","authors":"Pan Chen, Mujeeb Ur Rehman, Yanfeng He, Aoyun Li, Fuchun Jian, Longxian Zhang, Shucheng Huang","doi":"10.1080/01652176.2025.2452169","DOIUrl":"10.1080/01652176.2025.2452169","url":null,"abstract":"Coccidiosis is a global disease caused by protozoans, typically including Eimeria spp., which pose a significant threat to the normal growth and development of young animals. Coccidiosis affects mainly the gut, where parasite proliferation occurs. The intestinal barrier, which consists of chemical, mechanical, biological, and immune defences, plays a crucial role in protecting the host against pathogens, xenobiotics, and toxins present in the gastrointestinal tract. When animals ingest sporulated Eimeria spp. oocysts, these parasites primarily reproduce in the intestinal tract, causing damage to the structure and function of the intestine. This disruption of intestinal homeostasis adversely affects animal health. Numerous studies have also revealed that Eimeria-infected animals experience slower bone growth rates, inferior meat quality, reduced egg production and quality, as well as impaired growth and development. Therefore, the purpose of this review is to examine the underlying mechanisms through which Eimeria spp. regulate intestinal damage and disturb the balance of the internal environment. Specifically, this review will focus on their effects on the structural basis of the host intestine's chemical, mechanical, biological and immune barriers. This understanding is crucial for the development of effective drugs to prevent the invasion of Eimeria spp. into the intestine, which is of paramount importance for maintaining host health.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-22"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation of HuDo-CSPG4 DNA electroporation as adjuvant treatment for canine oral malignant melanoma: comparison of two vaccination protocols. HuDo-CSPG4 DNA电穿孔辅助治疗犬口腔恶性黑色素瘤的临床评价：两种疫苗接种方案的比较

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/01652176.2025.2473717

Mariateresa Camerino, Davide Giacobino, Lidia Tarone, Alfredo Dentini, Marina Martano, Emanuela Morello, Erica Ilaria Ferraris, Luca Manassero, Selina Iussich, Lorella Maniscalco, Federica Cavallo, Federica Riccardo, Paolo Buracco

{"title":"Clinical evaluation of HuDo-CSPG4 DNA electroporation as adjuvant treatment for canine oral malignant melanoma: comparison of two vaccination protocols.","authors":"Mariateresa Camerino, Davide Giacobino, Lidia Tarone, Alfredo Dentini, Marina Martano, Emanuela Morello, Erica Ilaria Ferraris, Luca Manassero, Selina Iussich, Lorella Maniscalco, Federica Cavallo, Federica Riccardo, Paolo Buracco","doi":"10.1080/01652176.2025.2473717","DOIUrl":"10.1080/01652176.2025.2473717","url":null,"abstract":"Canine oral malignant melanoma (OMM) is an aggressive, spontaneously occurring tumor carrying a poor to guarded prognosis and relatively limited therapeutic strategies. In this landscape, chondroitin sulfate proteoglycan (CSPG)4 represents a promising immunotherapeutic target. The objective of this bi-center prospective study was to examine the clinical outcome of OMM-bearing dogs treated with surgery and adjuvant electroporation using a DNA vaccine (HuDo-CSPG4) encoding both human (Hu) and canine (Do) portions of CSPG4 through two different vaccination protocols. Dogs with stage I-III surgically resected CSPG4-positive OMM underwent HuDo-CSPG4 plasmid electroporation starting at the 3rd-4th post-operative week; electrovaccination was repeated after 2 weeks. In protocol 1, electrovaccination was then delivered monthly while in protocol 2, electrovaccination was performed monthly four additional times followed by semestral boosters. The survival rates of HuDo-CSPG4-vaccinated dogs were estimated and compared with a control group treated with surgery alone. Significantly longer overall survival times were observed in HuDo-CSPG4 vaccinated dogs as compared with non-vaccinated controls. Dogs receiving protocol 2 showed similar outcomes to those of dogs undergoing protocol 1, despite fewer vaccinations. The comparable humoral response against CSPG4 resulting from the administration of protocol 1 and 2 appears to have similar clinical relevance, highlighting protocol 2 as the optimal vaccination schedule.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-16"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farm animal coronaviruses: the solution is in vaccines. 农场动物冠状病毒：解决方案在于疫苗。

IF 5.2 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1080/01652176.2025.2556494

Olga Kondakova, Anna Tsybina, Ekaterina Evtushenko, Ekaterina Ryabchevskaya, Dmitriy Granovskiy, Angelina Kovalenko, Marina Arkhipenko, Nikolai Nikitin, Olga Karpova

{"title":"Farm animal coronaviruses: the solution is in vaccines.","authors":"Olga Kondakova, Anna Tsybina, Ekaterina Evtushenko, Ekaterina Ryabchevskaya, Dmitriy Granovskiy, Angelina Kovalenko, Marina Arkhipenko, Nikolai Nikitin, Olga Karpova","doi":"10.1080/01652176.2025.2556494","DOIUrl":"10.1080/01652176.2025.2556494","url":null,"abstract":"RNA-containing coronaviruses are widespread in nature and can infect a number of vertebrates. Animals are potential sources of human coronaviruses diseases, and interspecies infection by animal coronaviruses has been recorded several times. Such a transmission may have caused the COVID-19 pandemic. The study and control of the spread of farm animals' coronavirus infections is very important, due to the constant close contact between humans and farm animals. Vaccination remains the key to preventing animal diseases and limiting the further spread and transmission of coronavirus infections among poultry and livestock. This review considers coronavirus infections in farm animals, which pose a serious challenge to animal husbandry, and their zoonotic potential and epidemiological features. The review also discusses current vaccines and their limitations, as well as the latest developments and trends in veterinary vaccines aimed at preventing coronavirus infections in poultry and livestock.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-29"},"PeriodicalIF":5.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population pharmacokinetic modeling of sulfadimethoxine, sulfadiazine and sulfamethoxazole combined to trimethoprim in pigs. 磺胺二甲氧嘧啶、磺胺嘧啶和磺胺甲恶唑与甲氧苄啶联用在猪体内的药代动力学模型。

IF 5.2 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1080/01652176.2025.2565351

Marine Boulanger, Jean-François Taillandier, Jérôme Henri, Mathias Devreese, Siegrid De Baere, Marlène Lacroix, Aude A Ferran, Alexis Viel

{"title":"Population pharmacokinetic modeling of sulfadimethoxine, sulfadiazine and sulfamethoxazole combined to trimethoprim in pigs.","authors":"Marine Boulanger, Jean-François Taillandier, Jérôme Henri, Mathias Devreese, Siegrid De Baere, Marlène Lacroix, Aude A Ferran, Alexis Viel","doi":"10.1080/01652176.2025.2565351","DOIUrl":"10.1080/01652176.2025.2565351","url":null,"abstract":"Sulfonamides (S) are old antibiotics combined with trimethoprim (TMP) for synergistic effects against pathogens responsible for a variety of infections in food-producing animals. In growing pigs, the TMP:S ratio is 1:5 based on human TMP/sulfamethoxazole (SMX) dosing which aims to obtain an in vivo ratio concentration of 1:19 considered as optimal against human pathogens. However, different sulfonamides with different pharmacokinetic profiles are used in pigs limiting this direct extrapolation from human. The aim was to conduct a PK study in pigs for three commonly used TMP/S combinations and to analyze data using population pharmacokinetic modeling. We found that a 2-compartment structural model fitted best the four drug PK data. TMP has the highest clearance values (0.48 L/h/kg) compared to SMX (0.21 L/h/kg), SDZ (0.12 L/h/kg) and SDMX (0.015 L/h/kg). SDMX has the longest plasma elimination half-life (14.8 h), followed by SDZ (3.7 h), TMP (2.9 h) and SMX (2.2 h). Monte Carlo simulations (n = 50,000 pigs) showed that only for 8.8%, 46.8%, and 76.5% of pigs for TMP/SMX, TMP/SDZ and TMP/SDMX, respectively, the free plasma concentration ratio fell within the range of 1:10-1:50 at the marketed doses administered. These results should be further linked to pharmacodynamics to optimize the use of these important antimicrobials drugs in veterinary medicine.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"2565351"},"PeriodicalIF":5.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular identification and biological characterization of Eimeria columbarum from domestic pigeons (Columba livia domestica) in Guangdong, China. 中国广东家鸽大肠埃默氏菌的分子鉴定和生物学特性。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1080/01652176.2024.2412297

Xi He, Xue-Mei Fang, Yu-Tong Qiao, Jia-Li Su, Sheng-Qiu Tang, Ya-Biao Weng, Rui-Qing Lin

{"title":"Molecular identification and biological characterization of Eimeria columbarum from domestic pigeons (Columba livia domestica) in Guangdong, China.","authors":"Xi He, Xue-Mei Fang, Yu-Tong Qiao, Jia-Li Su, Sheng-Qiu Tang, Ya-Biao Weng, Rui-Qing Lin","doi":"10.1080/01652176.2024.2412297","DOIUrl":"https://doi.org/10.1080/01652176.2024.2412297","url":null,"abstract":"Pigeon coccidiosis caused by Eimeria spp. is an important veterinary disease with a significant economic impact on the pigeon industry. Preventive measures for Eimeria columbarum in pigeons have been hampered by the lack of extensive genetic, morphological, and biological data on the oocysts. In this study, we examined the prevalence and identity of Eimeria spp. in domestic pigeons from seven cities in Guangdong Province, China. Data show that coccidiosis was prevalent in domestic pigeons in Guangdong Province, with an overall Eimeria spp. detection rate of 73.4%. Five Eimeria species were identified, including E. columbarum (73.4%), Eimeria kapotei (25.6%), Eimeria labbeana (19.6%), Eimeria duculai (19.6%), and Eimeria tropicalis (6.7%). We obtained single oocyst-derived lines of the dominant E. columbarum from fecal specimens. E. columbarum oocysts measured 20.06 ± 0.69 μm × 18.63 ± 1.03 μm, and sporocysts measured 10.29 ± 0.82 μm × 85.38 ± 0.46 μm. In infection experiment using obtained E. columbarum isolates, 60-day-old coccidia-free pigeons exhibited a prepatent period of 105 h and patent period of 9-10 days followed by severe diarrhea, depression, anorexia, and emaciation. Endogenous development of the parasite was observed mainly in the cytoplasm of epithelial cells in the duodenum, jejunum, ileum, and rectum. Two generations of meronts developed on days 3 and 4 after infection, respectively, while gamont and gamete developed on day 5 after infection. The morphological, genetic, and biological data are expected to be useful in elucidating the biological characterization of pigeon coccidiosis to develop measures against the treatment and containment of this disease.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-11"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of chronic stress status and quality of life in cats suffering from chronic kidney disease and suspected feline infectious peritonitis based on hair cortisol concentration analysis and a questionnaire. 根据毛发皮质醇浓度分析和问卷调查评估慢性肾病和疑似猫传染性腹膜炎患者的慢性应激状态和生活质量。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-07-19 DOI: 10.1080/01652176.2024.2379327

Chien-Hui Chen, Chao-Chin Chang, Wei-Che Chen, Ya-Jane Lee

{"title":"Evaluation of chronic stress status and quality of life in cats suffering from chronic kidney disease and suspected feline infectious peritonitis based on hair cortisol concentration analysis and a questionnaire.","authors":"Chien-Hui Chen, Chao-Chin Chang, Wei-Che Chen, Ya-Jane Lee","doi":"10.1080/01652176.2024.2379327","DOIUrl":"10.1080/01652176.2024.2379327","url":null,"abstract":"Hair cortisol concentration (HCC) and a questionnaire were used as indicators of chronic stress status and quality of life (QoL), respectively, in cats. To date, there has been limited research on the simultaneous application of both indicators in unwell cats. Our aim was to evaluate HCC and questionnaire data obtained from a healthy cat cohort (n = 61) and cat cohorts with either chronic kidney disease (CKD) (n = 78) or suspected feline infectious peritonitis (FIP) (n = 24). Furthermore, we also investigated the correlation between HCC and clinical pathological data. For this study, hair from the abdomen of cats was collected and analyzed for HCC using a commercial ELISA kit. Owners also completed a questionnaire, from which average-item-weighted-impact-scores (AWISs) were calculated. Cats with late-stage-CKD (median, HCC = 330.15 pg/mg, AWIS = -0.43) presented with a significantly higher HCC (p < 0.01) and a significantly lower AWIS (p < 0.01) than cats with early-stage-CKD (HCC = 183.56 pg/mg, AWIS = 1.08). Similarly, there were significant differences in both HCC (p < 0.001) and AWIS (p < 0.001) between cats with suspected FIP (HCC = 896.27 pg/mg, AWIS = -1.97) and healthy cats (HCC = 181.24 pg/mg, AWIS = 1.24). The degree of consistency between the HCC results and the questionnaire results reminds us that the severity of a chronic disease or the presence of a life-threatening disease can significantly increase stress and thus can affect the QoL of cats.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-9"},"PeriodicalIF":7.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study. 评估胰腺α-淀粉酶作为一种新型生物标记物在犬急性胰腺炎患者中的临床实用性：一项试点研究。

IF 6.4 2区农林科学

Veterinary Quarterly Pub Date : 2024-12-01 Epub Date: 2024-03-18 DOI: 10.1080/01652176.2024.2326007

Keon Kim, Hee-Hong Kim, Jae-Beom Joo, Ock-Kyu Kim, Sin-Wook Park, Guk-Hyun Suh, Woong-Bin Ro, Chang-Min Lee

{"title":"Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study.","authors":"Keon Kim, Hee-Hong Kim, Jae-Beom Joo, Ock-Kyu Kim, Sin-Wook Park, Guk-Hyun Suh, Woong-Bin Ro, Chang-Min Lee","doi":"10.1080/01652176.2024.2326007","DOIUrl":"10.1080/01652176.2024.2326007","url":null,"abstract":"Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p < .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. Furthermore, there was a significant difference in the median P-AMY dependent on the presence of systemic inflammatory response syndrome (p = .001). P-AMY showed similar level of diagnostic accuracy along with sensitivity and specificity compared to DGGR lipase. In addition, P-AMY showed a significant association with CAPS score, contrary to cPL and DGGR lipase. Along with other biomarkers associated with AP, P-AMY has the potential of usefulness as a supportive diagnostic and prognostic biomarker of AP in dogs.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"44 1","pages":"1-7"},"PeriodicalIF":6.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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