Veterinary Quarterly最新文献

{"title":"Absence of renal cortical anisotropic backscattering artifact in feline chronic kidney disease.","authors":"Ping-Hsien Chou,&nbsp;Hock Gan Heng,&nbsp;Fang-Ju Lin,&nbsp;Kuan-Sheng Chen","doi":"10.1080/01652176.2021.1941397","DOIUrl":"https://doi.org/10.1080/01652176.2021.1941397","url":null,"abstract":"<p><p>Renal cortical anisotropy backscattering artifact (CABA) is a focal hyperechoic region where the tubules are parallel to the incident ultrasound beam, reflecting most of the beams to the transducer. To investigate the association between chronic kidney disease (CKD) and the absence of renal CABA in cats. Ultrasonographic renal images of 40 cats with CKD (stage II-IV) and 36 clinically healthy cats were blindly evaluated by two observers to determine the visibility of renal CABA. Inter- and intraobserver agreements were evaluated using McNemar's test. The association between the absence of renal CABA and CKD was assessed using Fisher's exact test. Excellent intraobserver and substantial interobserver agreements were demonstrated. A significant association (<i>P</i> < .0001) between absent renal CABA and CKD stage was revealed in all cats. Cats with CKD had an increased risk of the absence of renal CABA (Odds ratio, 56.0; 95% CI, 13.8-227.0) compared with the clinically healthy cats. The absence of renal CABA revealed 87.5% sensitivity and 88.9% specificity to detect CKD in all cats, and 91.7% sensitivity and 83.3% specificity in aged cats. Our study demonstrated a correlation between feline CKD and the absence of renal CABA, providing a feasible and alternative method for feline CKD evaluation.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"210-216"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2021.1941397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of brucellosis control programs of livestock on the improvement of one health.","authors":"Maryam Dadar, Ruchi Tiwari, Khan Sharun, Kuldeep Dhama","doi":"10.1080/01652176.2021.1894501","DOIUrl":"10.1080/01652176.2021.1894501","url":null,"abstract":"<p><p>Brucellosis not only represents an important health restraint on livestock but also causes high economic losses in many developing countries worldwide. Despite considerable efforts made for the control of brucellosis, the disease is still spreading in many regions (such as the Middle East) where it represents one of the most important health hazards impacting both animals and humans. The present review aims to investigate the efficacy of veterinary control programs regarding brucellosis, with a special focus on current prevention, control, and eradication approaches. The reasons for unsuccessful control programs such as the absence of highly effective vaccines and non-certified bulls are also debated, to understand why the prevalence of brucellosis in livestock is not decreasing in many areas despite considerable efforts taken to date. The importance of governmental and regional investment in brucellosis control remains one of the main limiting factors owing to the limited budget allocated to tackle this disease. In this context, one health concept has generated novel comprehensive approaches with multiple economic implications across the livestock industry and public health. However, the implementation of such global preventive strategies appears to be a key issue for many endemic and low-income countries. According to the collected data, epidemiological contexts including management and trade systems along with well-defined agro-ecological zones should be evaluated in brucellosis endemic countries to improve milk production and to enhance the sustainability of the livestock sector at both national and regional levels.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"137-151"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25395077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of replication-deficient vesicular stomatitis virus based rabies vaccine in mice.","authors":"Jung-Eun Park, Hyun-Jin Shin","doi":"10.1080/01652176.2021.1930277","DOIUrl":"10.1080/01652176.2021.1930277","url":null,"abstract":"<p><strong>Background: </strong>Rabies is a viral disease that causes severe neurological manifestations both in humans and various mammals. Although inactivated and/or attenuated vaccines have been developed and widely used around the world, there are still concerns with regard to their safety, efficacy, and costs.</p><p><strong>Objective: </strong>As demand has grown for a new rabies vaccine, we have developed a new vesicular stomatitis viruses (VSVs) based rabies vaccine that replaces glycoproteins with rabies virus (RABV) glycoprotein (GP), or so-called VSV/RABV-GP.</p><p><strong>Methods: </strong>VSV/RABV-GP production was measured by sandwich ELISA. The generation of VSV/RABV-GP was evaluated with GP-specific antibodies and reduced transduction with GP-specific neutralizing antibodies. Virus entry was quantified by measuring the luciferase levels at 18-h post-transduction. BALB/c mice (three groups of six mice each) were intraperitoneally immunized with PBS, RABA, or VSV/RABV-GP at 0 and 14 days. At 28 days post-immunization serology was performed. Statistical significance was calculated using the Holm-Sidak multiple Student's <i>t</i> test.</p><p><strong>Results: </strong>Mice immunized with VSV/RABV-GP produced IgM and IgG antibodies, whereas IgM titers were significantly higher in mice immunized with VSV/RABV-GP compared to inactivated RABV. The secretion profiles of IgG1 and IgG2a production suggested that VSV/RAVB-GP induces the T helper cell type-2 immune bias. In addition, the average (±SD; <i>n</i> = 3) serum neutralization titers of the inactivated RABV and VSV/RABV-GP groups were 241 ± 40 and 103 ± 54 IU/mL, respectively.</p><p><strong>Conclusion: </strong>Our results confirm that VSV/RABV-GP could be a new potential vaccination platform for RABV.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"202-209"},"PeriodicalIF":7.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38979492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bovine vaccines against respiratory viruses administered either intranasal or intramuscular on broncho-alveolar fluid cells of heifers.","authors":"Patricia S Rossi,&nbsp;Rafael I Mattei,&nbsp;Natali R Schllemer,&nbsp;Gabriela R Thomaz,&nbsp;Anna V Antunes,&nbsp;Mauricio P Virmond,&nbsp;Mari J Taube,&nbsp;Heloisa G Bertagnon","doi":"10.1080/01652176.2020.1870019","DOIUrl":"https://doi.org/10.1080/01652176.2020.1870019","url":null,"abstract":"<p><strong>Background: </strong>The knowledge on bovine vaccines against respiratory viruses on bronchoalveolar fluid cells is scarce.</p><p><strong>Objective: </strong>To compare the effects of a commercial intranasal (IN) and intramuscular (IM) vaccine against bovine respiratory disease (BRD) complex viruses on bronchoalveolar fluid cells of healthy heifers.</p><p><strong>Methods: </strong>21 healthy heifers were assigned to three treatment groups: control (CO, N = 7), intranasally vaccinated (IN) (n = 7), and intramuscularly vaccinated (IM) (n = 7). The IN group received 1 mL of the commercial vaccine in each nostril once containing attenuated BoHV-1, bPIV-3, and BRSV. The IM group was vaccinated with two doses of 2 mL with an interval of 21 days of the commercial vaccine containing attenuated BoHV-1, bPIV-3, and BRSV plus inactivated BVDV. At day 0 (D0), before the first vaccine dose, and at D3, D7, and D21, after the last vaccine dose, airway bronchoscopy was performed to observe local irritation and collect bronchoalveolar lavage fluid (BALF). The bronchoalveolar count, cytological evaluation, bronchoalveolar cell oxidative metabolism, and total bronchoalveolar IgA and IgG were measured.</p><p><strong>Results: </strong>The IN vaccine increased neutrophil cellularity at D7 and D21 and total IgA at D3 in BALF. Total IgA in BALF also increased at D3 and oxidative metabolism of bronchoalveolar cells at D21 lowered compared to the CO group. Following IM vaccination there was no alteration of immunoglobulins or cell oxidative metabolism in BALF. Both vaccines reduced the number of alveolar macrophages.</p><p><strong>Conclusion: </strong>Both vaccines induced bronchoalveolar inflammation during the establishment of the vaccine immunity, which was more expressive in the IN protocol.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"97-106"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2020.1870019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38762302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic radiographic features of fatal paraquat intoxication in eleven dogs.","authors":"Yan-Wun Kuo,&nbsp;Lee-Shuan Lin,&nbsp;Yi-Chia Li,&nbsp;Kuan-Sheng Chen","doi":"10.1080/01652176.2021.1950945","DOIUrl":"https://doi.org/10.1080/01652176.2021.1950945","url":null,"abstract":"<p><strong>Background: </strong>Paraquat (1,1-dimethyl-4,4-bipyridinium dichloride) is a toxic herbicide. Accidental ingestion of paraquat in animals and humans causes respiratory failure and death.</p><p><strong>Aim: </strong>To describe the radiographic features of confirmed paraquat intoxication in a group of dogs and determines whether any identified features can facilitate this diagnosis.</p><p><strong>Methods: </strong>Eleven dogs diagnosed with paraquat intoxication were selected from two institutions between November 2014 and August 2019 comprising five males (all intact) and six females (one intact and five spayed). The mean age was 3.9 ± 2.9 (SD) years and their mean weight was 11.6 ± 5.0 kg. The tentative diagnosis was confirmed through analysis of their urine samples using a colorimetric assay (paraquat concentation 0.39 μg/ml ranging from 0.19-0.65 μg/ml), and their clinical signs were reviewed. Thoracic radiographs were evaluated for the presence of pneumomediastinum, lung patterns (interstitial or alveolar) and their locations (caudodorsal, cranioventral, diffuse, or symmetrical), subcutaneous emphysema, pneumoretroperitoneum, and pneumothorax.</p><p><strong>Results: </strong>The most common clinical signs were dyspnea (11/11, 100%) and anorexia (9/11, 82%). Pneumomediastinum (10/11, 91%) and symmetrically increased lung opacity (7/11, 65%) were the most common radiographic features. Pneumothorax (3/11, 27%), pleural effusion (3/11, 27%), subcutaneous emphysema (2/11, 18%), and pneumoretroperitoneum (1/5, 20%) were the less common findings. None of the dogs survived.</p><p><strong>Conclusion: </strong>Pneumomediastinum and diffuse or symmetrical interstitial or alveolar lung patterns are the most common radiographic features in dogs with paraquat intoxication.</p><p><strong>Clinical relevance: </strong>In countries where this herbicide is not banned, paraquat intoxication should be considered if dogs with no history of trauma present with pneumomediastinum.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"217-225"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2021.1950945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39083911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of ¹⁸F-FDG and ¹⁸F-FDOPA PET in an 8-year-old neutered male Yorkshire Terrier dog with glioma: long-term chemotherapy using hydroxyurea plus imatinib with prednisolone and immunoreactivity for PDGFR-β and LAT1.","authors":"Taesik Yun,&nbsp;Yoonhoi Koo,&nbsp;Sanggu Kim,&nbsp;Wonguk Lee,&nbsp;Hakhyun Kim,&nbsp;Dongwoo Chang,&nbsp;Soochong Kim,&nbsp;Mhan-Pyo Yang,&nbsp;Byeong-Teck Kang","doi":"10.1080/01652176.2021.1906466","DOIUrl":"https://doi.org/10.1080/01652176.2021.1906466","url":null,"abstract":"<p><p>An 8-year-old neutered male Yorkshire Terrier dog presented with head pressing, vestibular ataxia, neck tenderness, and no oculocephalic reflex. A demarcated lesion in the pons was identified on MRI. The patient was tentatively diagnosed with a glioma and was treated with hydroxyurea plus imatinib and prednisolone. After 30 days of therapeutic treatment, the patient showed a clear improvement in neurological signs, which lasted for 1117 days. On day 569 after the initiation of treatment, ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) was performed with no significant findings on visual analysis. The average and maximal standardized uptake values (SUVs) were 1.92 and 2.29, respectively. The tumor-to-normal-tissue (T/N) ratio was 0.97. The first evidence of clinical deterioration was noticed on day 1147. On day 1155, 3,4-dihydroxy-6-[¹⁸F]-fluoro-l-phenylalanine (¹⁸F-FDOPA)-PET was performed. High uptake of ¹⁸F-FDOPA was observed in the intracranial lesion. The mean and maximal SUVs of the tumor were 1.59 and 2.29, respectively. The T/N ratio was 2.22. The patient was euthanized on day 1155 and histopathologic evaluations confirmed glioma (astrocytoma). This case shows that chemotherapy with hydroxyurea plus imatinib may be considered in the treatment of canine glioma. Furthermore, this is the first case describing the application of ¹⁸F-FDG and ¹⁸F-FDOPA in a dog with glioma.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"163-171"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2021.1906466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25499422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib).","authors":"Jung-Hyun Kim,&nbsp;Dana Hyunjung Ahn,&nbsp;Je-Sung Moon,&nbsp;Hyun-Jung Han,&nbsp;Kieun Bae,&nbsp;Kyong-Ah Yoon","doi":"10.1080/01652176.2021.1905194","DOIUrl":"https://doi.org/10.1080/01652176.2021.1905194","url":null,"abstract":"<p><p>Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including <i>VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2</i>, and <i>B-RAF</i>, were analyzed. VEGFR was overexpressed in tumor tissues compared to the normal tissues. Considering the high frequency of B-RAF mutation in canine urological tumors, the <i>B-RAF</i> gene was examined, and the B-RAF V595E mutation was detected in the tumor tissue. Therefore, the antitumor effect of sorafenib, a multi-tyrosine kinase inhibitor, on unresectable metastatic urethral TCC characterized by B-RAF V595E was evaluated and circulating cell-free tumor DNA (ctDNA) was assessed for monitoring the treatment response. After the initiation of oral sorafenib therapy (4 mg/kg/day escalated to 10 mg/kg/day), the dysuria was alleviated gradually, and the patient remained stable for 3 months. During that treatment period, the patient showed various levels of changes associated with B-RAF V595E mutation in ctDNA as evident from longitudinal plasma samples after initiation of sorafenib therapy. The findings of this study suggest that ctDNA may serve as a useful non-invasive tool for monitoring the treatment response to anticancer drugs.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"153-162"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2021.1905194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25516463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological changes, distribution and detection of <i>Brucella melitensis</i> in foetuses of experimentally-infected does.","authors":"Mazlina Mazlan,&nbsp;Siti Khairani-Bejo,&nbsp;Hazilawati Hamzah,&nbsp;Nurrul Shaqinah Nasruddin,&nbsp;Annas Salleh,&nbsp;Mohd Zamri-Saad","doi":"10.1080/01652176.2020.1867328","DOIUrl":"https://doi.org/10.1080/01652176.2020.1867328","url":null,"abstract":"<p><strong>Background: </strong>Brucellosis of goats is caused by <i>Brucella melitensis.</i> It is a re-emerging zoonotic disease in many countries due to transmission from domestic animals and wildlife such as ibex, deer and wild buffaloes.</p><p><strong>Objective: </strong>To describe the pathological changes, identification and distribution of <i>B. melitensis</i> in foetuses of experimentally infected does.</p><p><strong>Methods: </strong>Twelve female goats of approximately 90 days pregnant were divided into 4 groups. Group 1 was exposed intra-conjunctival to 100 µL of sterile PBS while goats of Groups 2, 3 and 4 were similarly exposed to 100 µL of an inoculum containing 10⁹ CFU/mL of live <i>B. melitensis.</i> Goats of these groups were killed at 15, 30 and 60 days post-inoculation, respectively. Foetal fluid and tissues were collected for bacterial identification (using direct bacterial culture, PCR and immuno-peroxidase staining) and histopathological examination.</p><p><strong>Results: </strong>Bilateral intra-conjunctival exposure of pregnant does resulted in <i>in-utero</i> infection of the foetuses. All full-term foetuses of group 4 were either aborted or stillborn, showing petechiations of the skin or absence of hair coat with subcutaneous oedema. The internal organs showed most severe lesions. Immune-peroxidase staining revealed antigen distribution in all organs that became most extensive in group 4. <i>Brucella melitensis</i> was successfully isolated from the stomach content, foetal fluid and various other organs.</p><p><strong>Conclusion: </strong>Vertical transmission of caprine brucellosis was evident causing mild to moderate lesions in different organs. The samples of choice for isolation and identification of <i>B. melitensis</i> are stomach content as well as liver and spleen tissue.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"36-49"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2020.1867328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38739952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction notice.","authors":"M Samardžija,&nbsp;M Lojkić,&nbsp;N Maćešić,&nbsp;H Valpotić,&nbsp;I Butković,&nbsp;J Šavorić,&nbsp;I Žura Žaja,&nbsp;D Leiner,&nbsp;D Đuričić,&nbsp;F Marković,&nbsp;P Kočila,&nbsp;Ž Vidas,&nbsp;M Gerenčer,&nbsp;A Kaštelan,&nbsp;A Milovanović,&nbsp;M Lazarević,&nbsp;D Rukavina,&nbsp;I Valpotić","doi":"10.1080/01652176.2021.1884347","DOIUrl":"https://doi.org/10.1080/01652176.2021.1884347","url":null,"abstract":"","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"152"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01652176.2021.1884347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25586754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 natural infection in animals: a systematic review of studies and case reports and series.","authors":"D Katterine Bonilla-Aldana,&nbsp;Alejandra García-Barco,&nbsp;S Daniela Jimenez-Diaz,&nbsp;Jorge Luis Bonilla-Aldana,&nbsp;Maria C Cardona-Trujillo,&nbsp;Fausto Muñoz-Lara,&nbsp;Lysien I Zambrano,&nbsp;Luis A Salas-Matta,&nbsp;Alfonso J Rodriguez-Morales","doi":"10.1080/01652176.2021.1970280","DOIUrl":"https://doi.org/10.1080/01652176.2021.1970280","url":null,"abstract":"<p><p>COVID-19 pandemic is essentially a zoonotic disease. In this context, early in 2020, transmission from humans to certain animals began reporting; the number of studies has grown since. To estimate the pooled prevalence of SARS-CoV-2 natural infection in animals and to determine differences in prevalence between countries, years, animal types and diagnostic methods (RT-PCR or serological tests). A systematic literature review with meta-analysis using eight databases. Observational studies were included but analyzed separately. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95% CI) for prevalence studies and case series. After the screening, 65 reports were selected for full-text assessment and included for qualitative and quantitative analyses. A total of 24 reports assessed SARS-CoV-2 infection by RT-PCR, combining a total of 321,785 animals, yielding a pooled prevalence of 12.3% (95% CI 11.6%-13.0%). Also, a total of 17 studies additionally assessed serological response against SARS-CoV-2, including nine by ELISA, four by PRTN, one by MIA, one by immunochromatography (rest, two studies, the method was not specified), combining a total of 5319 animals, yielding a pooled prevalence of 29.4% (95% CI 22.9%-35.9%). A considerable proportion of animals resulted infected by SARS-CoV-2, ranking minks among the highest value, followed by dogs and cats. Further studies in other animals are required to define the extent and importance of natural infection due to SARS-CoV-2. These findings have multiple implications for public human and animal health. One Health approach in this context is critical for prevention and control.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"41 1","pages":"250-267"},"PeriodicalIF":6.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39322545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}