Social Studies of Science最新文献_第3页

A precision immuno-oncology turn? Hybridizing cancer genomics and immunotherapy through neoantigens-based adoptive cell therapies 精准免疫肿瘤学转向？杂交癌症基因组学和免疫疗法通过新抗原为基础的过继细胞疗法

IF 3 2区社会学

Social Studies of Science Pub Date : 2024-12-16 DOI: 10.1177/03063127241303720

Luca Chiapperino, Nils Graber, Francesco Panese

{"title":"A precision immuno-oncology turn? Hybridizing cancer genomics and immunotherapy through neoantigens-based adoptive cell therapies","authors":"Luca Chiapperino, Nils Graber, Francesco Panese","doi":"10.1177/03063127241303720","DOIUrl":"https://doi.org/10.1177/03063127241303720","url":null,"abstract":"This article explores the development of T cell-based therapies in Switzerland. These therapies, which elicit the immunological potential of each patient to respond to tumor development, constitute a major promise for so-called ‘precision oncology’. We document how immunological concepts, technologies, and practices are articulated given the centrality of genomics in ‘precision oncology’. We consider ‘precision immunotherapies’ to probe whether and how change ensues in these established sociotechnical regimes of biomedicine. The case of genomics and immunology in oncology offers a unique insight into the conditions of possibility for change in such regimes. How does the present new wave of cancer immunotherapies challenge, integrate, and complement the centrality of genomics in ‘precision oncology’? What are the specific processes that make possible the convergence, competition, or co-existence of distinct conceptions, infrastructures, and programs of innovative cancer medicine? Drawing from observations and interviews with researchers and clinicians, we qualify these sociotechnical processes as hybridizations. Bringing together different sociotechnical regimes of biomedical research is conditional to the articulation of core concepts, technologies, and translational practices of genomics and immunology. Pivotal to this objective are neoantigens, cell surface proteins originating from the somatic genetic mutations of tumors and which activate a patient’s immune response. While neoantigens are an unstable entity in experimentation, they offer a conceptual and material substrate to renegotiate the dominance of cancer genomics, and initiate the production of a new, hybrid regime of ‘immunogenomic precision’ in oncology.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"252 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unboxing the imaginary: Typology of future imagination techniques in high-tech development. 打开想象的盒子：高科技发展中未来想象技术的类型学。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-12-11 DOI: 10.1177/03063127241300625

Limor Samimian-Darash, Amit Sheniak, Nir Rotem

{"title":"Unboxing the imaginary: Typology of future imagination techniques in high-tech development.","authors":"Limor Samimian-Darash, Amit Sheniak, Nir Rotem","doi":"10.1177/03063127241300625","DOIUrl":"https://doi.org/10.1177/03063127241300625","url":null,"abstract":"When the future is connected to the term 'imagination', it is generally presented through the concept of the 'imaginary'-that is, an image of the future that is related to a grand social image. In this article, we discuss the concept of sociotechnical imaginaries and argue that although this concept provides a needed perspective that allows scholars to unpack imaginaries associated with technological futures, it often features very broad concepts, hindering investigation of the ongoing dynamics of the actual acts of imagining and imagination. In contrast, we are interested in examining the processes and practices of imagination of socio-technical futures. Attempting to extend and deepen the development of this prevalent approach in STS, we make three incremental claims. First, future imaginaries should be addressed as a product of a process of imagination, not just in their final stable states. Second, exploring the process of future imagination reveals the effect of different temporalities-patterns of future imagination that expand the common singular far-future imaginary. Third, using a temporality-based analysis, we can identify different future planning techniques and practices in terms of their levels of formality and institutionalization.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":" ","pages":"3063127241300625"},"PeriodicalIF":2.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearts and minds: The technopolitical role of affect in sociotechnical imaginaries. 心与心：情感在社会技术想象中的技术政治作用。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-12-01 Epub Date: 2024-06-06 DOI: 10.1177/03063127241257489

Stephen Hughes

{"title":"Hearts and minds: The technopolitical role of affect in sociotechnical imaginaries.","authors":"Stephen Hughes","doi":"10.1177/03063127241257489","DOIUrl":"10.1177/03063127241257489","url":null,"abstract":"Sociotechnical imaginaries (SIs) have emerged as a popular and generative concept within Science and Technology Studies (STS). This article draws out the affective component of SIs, combining a review of relevant literatures with an empirical case study of an anti-fracking imaginary in Ireland to suggest how we might theorize an affective technopolitics of SIs. The literature review identifies three key aspects of SIs that would benefit from a more coherent conceptualization of affect: the utopian, productive, and collectivizing dimensions of imaginaries. Emotions such as desire and fear appear prominently in the SI literature, but in ways that require development. Using empirical examples from my research, I outline what this developed understanding of emotions in imaginaries might look like. I examine the role that emotions played in the development and settlement of an anti-fracking imaginary in Ireland, highlighting how the intensive, multimodal, and dynamic nature of affect underpinned the productive, collective, and utopian dimensions of the SI. I conclude with some remarks about how this developed theory of emotion positions STS researchers to address issues of humanity, representation, and the building of better worlds.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":" ","pages":"907-930"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population curation: The construction of mutual obligation between individual and state in Danish precision medicine. 人口策展：丹麦精准医疗中个人与国家之间相互义务的构建。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-12-01 Epub Date: 2024-05-31 DOI: 10.1177/03063127241255971

Iben M Gjødsbøl, Jeanette Bresson Ladegaard Knox, Lea Skovgaard, Mette N Svendsen

{"title":"Population curation: The construction of mutual obligation between individual and state in Danish precision medicine.","authors":"Iben M Gjødsbøl, Jeanette Bresson Ladegaard Knox, Lea Skovgaard, Mette N Svendsen","doi":"10.1177/03063127241255971","DOIUrl":"10.1177/03063127241255971","url":null,"abstract":"How do precision medicine initiatives (re)organize relations between individuals and populations? In this article, we investigate how the curation of national genomic populations enacts communities and, in so doing, constructs mutual obligation between individuals and the state. Drawing on ethnographic fieldwork in the Danish National Genome Center (DNGC), we show how members of advisory bodies negotiated the inclusion criteria for two different genomic populations: a patient genome population and an envisioned 'Danish' reference genome population. The patient genome population was curated through a politics of inclusion, of as many genomes as possible, whereas the reference genome was to be curated through a politics of exclusion, to include only the genomes of 'ethnic' Danes. These two data populations configure differently the community of 'Danish patients' who might benefit from precision medicine, and thereby prescribe different moral continuities between person, state, and territory. We argue that the DNGC's patient genome population reinforces reciprocal relations of obligations and responsibility between the Danish welfare state and all individuals, while the proposed Danish reference genome population privileges the state's commitment to individuals with biographical-territorial belonging to the nation-state. Drawing on scholarship on social and health citizenship, as well as data solidarity in the Nordics, the discussion shows how population curation in national precision medicine initiatives might both construct and stratify political obligation. Whereas STS scholarship has previously deconstructed the concept of 'population', in the context of the troubling and violent effects of the management of human populations, we point to the importance of population curation as a vehicle for making the individual legible as part of a community to which the state is responsible and for which it is committed to care.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":" ","pages":"883-906"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cells and the city: The rise and fall of urban biopolitics in San Francisco, 1970-2020. 细胞与城市：1970-2020年旧金山城市生物政治的兴衰。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-12-01 Epub Date: 2024-07-23 DOI: 10.1177/03063127241261376

Andy Murray, Dennis Browe, Katherine Weatherford Darling, Jenny Reardon

{"title":"Cells and the city: The rise and fall of urban biopolitics in San Francisco, 1970-2020.","authors":"Andy Murray, Dennis Browe, Katherine Weatherford Darling, Jenny Reardon","doi":"10.1177/03063127241261376","DOIUrl":"10.1177/03063127241261376","url":null,"abstract":"STS theories of biocapital conceptualize how biomedical knowledge and capital form together. Though these formations of biocapital often are located in large urban centers, few scholars have attended to how they are transforming urban spaces and places. In this paper we argue that the twinned technological development of cells and cities concentrates economic and symbolic capital and sets in motion contentious practices we name urban biopolitics. We draw on archival research and a nearly decade-long ethnography of the expansion of biomedical campuses in a major American city to show how the speculative logics of land development and biomedical innovation become bound together in a process we describe as speculative revitalization. We examine how the logics of speculative revitalization imagine a future in which cities and biomedicine produce wealth and health harmoniously together. However, in practice-as buildings of new biomedical urban campuses get built-the dreams of billionaire philanthrocapitalists to create global cities clash with the plans of biomedical researchers to create global health. We document the reproduction of stratified and racialized biomedical exclusions that result while also highlighting the unlikely opportunities for creating alliances committed to creating equitable biomedical research and healthcare in urban communities.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":" ","pages":"805-835"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wake effects and temperature plumes: Coping with non-knowledge in the expansion of wind and geothermal energy. 唤醒效应和温度羽流：应对风能和地热能扩张过程中的不可知性。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1177/03063127241246551

Marco Sonnberger, Maria Pfeiffer, Alena Bleicher, Matthias Gross

引用次数: 0

What work does ‘contamination’ do? An agential realist account of oil wastewater and radium in groundwater 污染 "做了什么工作？石油废水和地下水中的镭的代理现实主义论述

IF 3 2区社会学

Social Studies of Science Pub Date : 2024-11-14 DOI: 10.1177/03063127241281708

Vivian Underhill, Karen Barad

{"title":"What work does ‘contamination’ do? An agential realist account of oil wastewater and radium in groundwater","authors":"Vivian Underhill, Karen Barad","doi":"10.1177/03063127241281708","DOIUrl":"https://doi.org/10.1177/03063127241281708","url":null,"abstract":"Oil wastewater often contains high levels of radium, a carcinogenic and radioactive element. This article closely engages with two investigations of radium in groundwater downstream from oil wastewater storage pits. While one investigation found that radium did not travel beyond the storage pits, the other found evidence of elevated radium some two kilometers downstream. With an agential realist analysis, we resolve these differences, showing that these two experimental apparatuses defined and mobilized two different phenomena of radium, and of radium-as-contaminant. What geologists call ‘rock-water interactions’ are materially meaningful intra-actions. Far from being a mere philosophical gloss on otherwise conventional science, the ‘intra-’ signifies that, in these processes, the sediment and the groundwater are bringing each other into being. Groundwater sampling entails a specific set of intra-actions with the subsurface that enact different agential cuts. In addition, a geochemical focus on objects, rather than relations, also constrains understandings of chemical harm and accountability. These concepts do not only affect experimental apparatuses; rather, they come into being through and with each other. Therefore, rigorous approaches to groundwater and remediation do not lie in the pull to reify individual groundwater constituents, or to arbitrate between ‘contaminant’ and ‘contaminated’. Rather, rigorous approaches lie in the role of chemical relations in constituting specific groundwater phenomena. We elaborate three aspects of these relations: the constitution of radium-as-isolated-element through the ontological work of sampling schema, the formation of scale and attendant spacetimematterings within experimental apparatuses, and the work of contamination logics within conceptualizations of chemical harm. This analysis has major implications for understanding the potential harm of oil wastewater to groundwater.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"6 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing digital assets through blockchain technologies? Unpacking the techno-economic configuration of non-fungible tokens. 通过区块链技术构建数字资产？解读不可流通代币的技术经济结构。

IF 2.9 2区社会学

Social Studies of Science Pub Date : 2024-11-14 DOI: 10.1177/03063127241286447

Alia Miroshnichenko, Kean Birch

引用次数: 0

‘Zoonati’ vs. ‘epistemic tresspasers’: Science identity in contentious online advocacy campaigns on the origins of SARS-CoV-2 Zoonati "与 "践踏认识论者"：关于 SARS-CoV-2 起源的有争议的在线宣传活动中的科学认同

IF 3 2区社会学

Social Studies of Science Pub Date : 2024-11-12 DOI: 10.1177/03063127241294028

Lynn Horton

引用次数: 0

Anthropocene angst: Authentic geology and stratigraphic sincerity 人类世的焦虑真实的地质学和地层学的诚意