Medicinski Glasnik最新文献_第3页

The importance of early diagnosis of congenital torticollis: a five-year retrospective study at a tertiary centre. 早期诊断先天性斜颈的重要性：在三级中心的五年回顾性研究。

Medicinski Glasnik Pub Date : 2026-07-29 DOI: 10.17392/medglas-2178-23-2

Selma Muratović, Gordana Grgić, Anis Cerovac, Dubravko Habek, Azra Hadžimedmedović, Asja Terzić

{"title":"The importance of early diagnosis of congenital torticollis: a five-year retrospective study at a tertiary centre.","authors":"Selma Muratović, Gordana Grgić, Anis Cerovac, Dubravko Habek, Azra Hadžimedmedović, Asja Terzić","doi":"10.17392/medglas-2178-23-2","DOIUrl":"10.17392/medglas-2178-23-2","url":null,"abstract":"Aim: To determine the frequency of congenital muscular torticollis (CMT), identify associated risk factors and assess common associated neonatal conditions.Methods: This retrospective study reviewed medical records of newborns diagnosed with CMT at the Clinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, from 1 January 2019 to 31 December 2023. Data on maternal, pregnancy, delivery, neonatal and physiotherapy-related variables were analysed.Results: During the five-year period, 16,899 newborns were delivered, of whom 141 (0.83%) were diagnosed with CMT. CMT was most frequent among newborns of primiparous mothers (94; 66.7%) and after vaginal delivery (78; 55.3%). Most newborns had an Apgar score ≥8 (108; 76.6%) and were born at ≥37 weeks of gestation (130; 92.2%). CMT was slightly more common in female newborns (73; 51.8%) and was more often right-sided (88; 62.4%). Complete recovery was reported among all newborns with available physiotherapy follow-up data.Conclusion: The frequency of CMT over the five-year period was 0.83%. Early diagnosis and timely initiation of physical therapy were associated with complete recovery among newborns with available follow-up data.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cell-derived secretome may attenuate nephrotoxicity by modulating cyclooxygenase-2 and caspase-3 levels in Wistar rats: an ELISA-based analysis. 间充质干细胞衍生的分泌组可能通过调节Wistar大鼠的环氧化酶-2和caspase-3水平来减轻肾毒性：一项基于elisa的分析。

Medicinski Glasnik Pub Date : 2026-07-29 DOI: 10.17392/medglas-2177-23-2

Dedy Syahrizal, Rika Farhana, Jufriady Ismy, Fauzul Husna, Zulkarnain Zulkarnain, Agung Pranata

{"title":"Mesenchymal stem cell-derived secretome may attenuate nephrotoxicity by modulating cyclooxygenase-2 and caspase-3 levels in Wistar rats: an ELISA-based analysis.","authors":"Dedy Syahrizal, Rika Farhana, Jufriady Ismy, Fauzul Husna, Zulkarnain Zulkarnain, Agung Pranata","doi":"10.17392/medglas-2177-23-2","DOIUrl":"10.17392/medglas-2177-23-2","url":null,"abstract":"Aim: Nephrotoxicity is a major clinical concern because it can impair kidney function through inflammation and apoptosis. This study aimed to evaluate the effects of mesenchymal stem cell (MSC)-derived secretome on cyclooxygenase-2 (COX-2) and caspase-3 levels in a rat model of doxorubicin-induced nephrotoxicity.Methods: A total of 24 male Wistar rats were randomly allocated into four groups: normal control (NC), nephrotoxicity control (TC), early MSC-derived secretome treatment (P1), and delayed MSC-derived secretome treatment (P2). Nephrotoxicity was induced using a single intraperitoneal injection of doxorubicin (10 mg/kg body weight). MSC-derived secretome was administered intravenously (0.15 mL) immediately after doxorubicin injection in the P1 group, and administered to the P2 group on day 5 after doxorubicin injection. All rats were euthanised on day 12. COX-2 and caspase-3 levels were measured using enzyme-linked immunosorbent assay (ELISA).Results: A significant overall difference in COX-2 levels was observed among groups (p = 0.035). A strong, statistically significant positive correlation was observed between COX-2 and caspase-3 levels (r = 0.684, p = 0.002). The lowest COX-2 levels were found in the P1 group. No significant differences in caspase-3 levels were observed.Conclusion: This study showed a significant overall difference in renal COX-2 levels among groups in a doxorubicin-induced nephrotoxicity rat model; however, Holm-adjusted post hoc comparisons did not confirm significant pairwise differences. Caspase-3 levels did not differ significantly among groups. These findings suggest that MSC-derived secretome may have potential anti-inflammatory effects, particularly when administered early after doxorubicin exposure, but further studies are required to confirm its effects on renal inflammation and apoptosis.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of telehealth in autism spectrum disorder management: a scoping review. 远程医疗在自闭症谱系障碍管理中的作用：范围审查。

Medicinski Glasnik Pub Date : 2026-07-29 DOI: 10.17392/medglas-2179-23-2

Gjergji Doka, Ylli Aliçka, Dasantila Tahiraj, Brunilda Elezi, Venemin Gega, Eliona Sula

{"title":"The role of telehealth in autism spectrum disorder management: a scoping review.","authors":"Gjergji Doka, Ylli Aliçka, Dasantila Tahiraj, Brunilda Elezi, Venemin Gega, Eliona Sula","doi":"10.17392/medglas-2179-23-2","DOIUrl":"10.17392/medglas-2179-23-2","url":null,"abstract":"Aim: To map and summarise evidence on the role, benefits and challenges of telehealth in autism spectrum disorder (ASD) management, including assessment and intervention.Methods: This scoping review searched PubMed and Scopus for English-language studies published from 2015 to 2025; the search was last updated on 14 April 2026. Nine studies met the eligibility criteria, comprising randomised controlled trials and observational, mixed-methods, descriptive, pilot, and qualitative studies.Results: Available findings suggest that telehealth-based assessment may achieve high diagnostic concordance with in-person evaluation, and that telehealth-delivered interventions may yield similar outcomes in selected domains. Several studies reported high caregiver and clinician satisfaction. Key challenges included technological access barriers, variability in caregiver engagement, and concerns regarding reliability and equity in under-resourced settings.Conclusion: Telehealth may be a valuable complement to, rather than a replacement for, in-person care. Future primary studies should use rigorous designs and standardised outcome measures and should prioritise linguistically diverse and low-resource populations; future evidence syntheses should include formal risk-of-bias assessment.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil reactivity intensity correlates with the SOFA score in adults with sepsis: a cross-sectional study from an Indonesian tertiary hospital. 中性粒细胞反应性强度与成人脓毒症SOFA评分相关：来自印度尼西亚三级医院的横断面研究。

Medicinski Glasnik Pub Date : 2026-07-29 DOI: 10.17392/medglas-2180-23-2

Ester Maduma Napitupulu, Malayana Rahmita Nasution, Andriamuri Primaputra Lubis, Nindia Sugih Arto, Ranti Permatasari

{"title":"Neutrophil reactivity intensity correlates with the SOFA score in adults with sepsis: a cross-sectional study from an Indonesian tertiary hospital.","authors":"Ester Maduma Napitupulu, Malayana Rahmita Nasution, Andriamuri Primaputra Lubis, Nindia Sugih Arto, Ranti Permatasari","doi":"10.17392/medglas-2180-23-2","DOIUrl":"10.17392/medglas-2180-23-2","url":null,"abstract":"Aim: To assess the correlations of neutrophil reactivity intensity (NEUT-RI) and neutrophil granularity intensity (NEUT-GI) with the Sequential Organ Failure Assessment (SOFA) score in adults with sepsis.Methods: This cross-sectional study included 52 adult inpatients with sepsis at H. Adam Malik General Hospital, Medan, Indonesia, in September 2025. NEUT-RI and NEUT-GI were measured using a Sysmex XN-1000 haematology analyser, and SOFA scores were obtained from medical records. Associations were analysed using Pearson correlation and linear regression. Receiver-operating-characteristic (ROC) analysis for SOFA ≥6 was exploratory because the cut-off was derived and evaluated in the same sample.Results: The median age was 56 years (IQR 46-64), 29/52 (55.8%) participants were male, and the median SOFA score was 6 (IQR 4-8). NEUT-RI correlated strongly with the SOFA score (r = 0.819; 95% CI 0.704-0.893; R² = 0.671; p < 0.001) and remained independently associated after adjustment for age, sex, NEUT-GI, and log-transformed leukocyte count (B = 0.370; 95% CI 0.294-0.446; standardised β = 0.82; p < 0.001). Exploratory ROC analysis yielded an in-sample AUC of 0.994 for SOFA ≥6 at a cut-off of 49.9 FI. NEUT-GI was not significantly associated with SOFA (r = 0.068; p = 0.631).Conclusion: NEUT-RI, but not NEUT-GI, was independently associated with concurrent organ-dysfunction severity in adults with sepsis. Prospective validation is required before clinical application.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety-focused triage of suspected bacterial urinary tract infection using urine flow cytometry outputs: prediction of culture positivity. 利用尿流式细胞术输出的疑似细菌性尿路感染的安全分诊：培养阳性预测。

Medicinski Glasnik Pub Date : 2026-07-22 DOI: 10.17392/medglas-2175-23-2

Dyah Ganis Kusumawardhani, Dwi Rahayuningsih, Ferdy Royland Marpaung, Aryati Aryati

{"title":"Safety-focused triage of suspected bacterial urinary tract infection using urine flow cytometry outputs: prediction of culture positivity.","authors":"Dyah Ganis Kusumawardhani, Dwi Rahayuningsih, Ferdy Royland Marpaung, Aryati Aryati","doi":"10.17392/medglas-2175-23-2","DOIUrl":"10.17392/medglas-2175-23-2","url":null,"abstract":"Aim: To evaluate the urine flow cytometry flagging feature (UF-5000) for predicting urine culture positivity and assess the agreement between BACT-info Gram outputs and culture Gram classification, with subgroup analyses in catheterised, immunosuppressed, and age-stratified patients.Methods: This single-centre cross-sectional diagnostic accuracy study included 885 routine urine samples with paired UF-5000 analysis and culture results (440 culture-positive, 445 culture-negative). The diagnostic performance of the urinary tract infection (UTI)-flag (UTI vs. non-UTI) was calculated with Wilson 95% confidence intervals. Agreement between two BACT-info definitions and culture Gram category was also evaluated.Results: UTI flagging demonstrated a sensitivity of 0.670, specificity of 0.921, positive predictive value (PPV) of 0.894, negative predictive value (NPV) of 0.739, and an accuracy of 0.797. The negative predictive value declined markedly in high-risk subgroups: catheterised patients (NPV, 0.612) and immunosuppressed patients (NPV, 0.500). Sensitivity was substantially lower in males (0.412) than in females (0.833). Indicator-derived Gram classification showed excellent agreement with culture Gram category (κ = 0.826), whereas categorical BACT-info label mapping yielded fair agreement (κ = 0.294). Bacterial count (BACT) discriminated culture positivity with an area under the curve (AUC) of 0.812 (optimal cut-off 487/µL, sensitivity 0.795, specificity 0.807), whereas white blood cell count (WBC) showed an AUC of 0.749 (cut-off 76.9/µL, sensitivity 0.735, specificity 0.773).Conclusion: UF-5000 UTI flagging provides strong rule-in utility for bacterial UTI triage but should not be used as a universal rule-out test, particularly in catheterised and immunosuppressed patients. The BACT count improves discrimination and may support safety-oriented overriding rules.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience. 旋转动脉粥样硬化切除术和改良球囊用于钙化病变准备的比较：单中心经验。

Medicinski Glasnik Pub Date : 2026-07-22 DOI: 10.17392/medglas-2176-23-2

Domagoj Mišković, Krešimir Gabaldo, Josip Silović, Jelena Jakab, Katica Cvitkušić Lukenda, Ana Đanić Hadžibegović, Jakov Milić, Marijana Knežević Praveček, Irzal Hadžibegović

{"title":"Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience.","authors":"Domagoj Mišković, Krešimir Gabaldo, Josip Silović, Jelena Jakab, Katica Cvitkušić Lukenda, Ana Đanić Hadžibegović, Jakov Milić, Marijana Knežević Praveček, Irzal Hadžibegović","doi":"10.17392/medglas-2176-23-2","DOIUrl":"10.17392/medglas-2176-23-2","url":null,"abstract":"Aim: To compare the efficacy and safety of rotational atherectomy (RA) and modified balloons (MB) for calcified coronary lesion preparation.Methods: This retrospective, single-centre study included 92 consecutive patients with angiographically significant coronary artery calcification (CAC) treated between September 2021 and December 2024. Patients were stratified according to lesion-preparation strategy: RA with the RotaPro system (Boston Scientific, Marlborough, MA, USA) (n = 42) or MB, including scoring or cutting balloons (n = 50). Patients treated with intravascular lithotripsy, super-high-pressure balloons, or non-compliant balloons alone were excluded. The primary endpoint was 1-year cardiovascular mortality, and the secondary endpoint was procedural success, defined as successful stent or drug-coated balloon implantation with <10% residual stenosis and final Thrombolysis in Myocardial Infarction grade 3 flow.Results: Baseline age and renal function were comparable between groups. Microcatheter use was more frequent in the RA group (p<0.001), whereas smoking was more prevalent in the MB group (p=0.043). Fluoroscopy time was longer in the RA group (p<0.001). Cardiovascular mortality and procedural success did not differ significantly between groups.Conclusion: In this real-world single-centre experience, RA and MB showed comparable feasibility and one-year clinical outcomes for the treatment of CAC. A lesion-specific approach integrating RA, MB and intravascular lithotripsy may optimise the management of calcified coronary lesions.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local carboxymethyl-β-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study. 局部羧甲基-β-葡聚糖和多碳粒细胞治疗与低级别宫颈细胞学异常的消退有关：一项前瞻性观察研究。

Medicinski Glasnik Pub Date : 2026-07-22 DOI: 10.17392/medglas-2174-23-2

Melika Dervišefendić Peljto, Mahira Jahić

{"title":"Local carboxymethyl-β-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study.","authors":"Melika Dervišefendić Peljto, Mahira Jahić","doi":"10.17392/medglas-2174-23-2","DOIUrl":"10.17392/medglas-2174-23-2","url":null,"abstract":"Aim: To evaluate the association between intravaginal therapy with carboxymethyl-β-glucan (CMBG) and polycarbophil and cytological regression of atypical squamous cells of undetermined significance (ASCUS) and cervical intraepithelial neoplasia grade 1 (CIN 1), compared with standard follow-up.Methods: This prospective observational controlled study included 80 women aged 23-49 years with ASCUS or CIN 1. Forty patients received intravaginal CMBG/polycarbophil spray, and 40 were managed with standard follow-up. Allocation was based on clinical assessment and therapy availability, without randomisation. The primary outcome was cytological normalisation after 12 months, based on Papanicolaou smear results.Results: After 12 months, abnormal cytology was observed in 4 (10.0%) patients in the treatment group and 18 (45.0%) in the control group (RR 0.22; 95% CI 0.08-0.60; p < 0.001). Normal cytology was observed in 36 (90.0%) and 22 (55.0%) patients, respectively (p < 0.001). Human papillomavirus (HPV) persistence was detected in 2 (5.0%) patients in the treatment group and 5 (12.5%) in the control group (p = 0.432).Conclusion: Intravaginal CMBG/polycarbophil therapy was associated with a higher rate of cytological normalisation than standard follow-up in women with ASCUS and CIN 1.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategy-based revascularization for complex femoropopliteal disease: endovascular-first versus surgical bypass in contemporary practice. 基于策略的复杂股腘动脉疾病血运重建术：当代实践中的血管内优先与外科旁路手术

Medicinski Glasnik Pub Date : 2026-07-21 DOI: 10.17392/medglas-2171-23-2

Emced Khalil, Burak Yüksel

{"title":"Strategy-based revascularization for complex femoropopliteal disease: endovascular-first versus surgical bypass in contemporary practice.","authors":"Emced Khalil, Burak Yüksel","doi":"10.17392/medglas-2171-23-2","DOIUrl":"10.17392/medglas-2171-23-2","url":null,"abstract":"Aim: To compare the outcomes of endovascular treatment (EVT) and surgical bypass (BP) for the management of complex femoropopliteal (FP) artery disease.Methods: This retrospective single-centre cohort study included patients with Trans-Atlantic Inter-Society Consensus (TASC II) C-D lesions in the FP segment treated between 2018 and 2023. The patients were categorized into two groups according to treatment strategy: EVT and surgical BP. The primary outcome was primary patency at 12 and 24 months. Secondary outcomes included target lesion revascularization, amputation-free survival, major amputation, and procedural complications.Results: A total of 168 patients were included, with 98 patients in the EVT group and 70 patients in the BP group. Patients in the BP group had significantly longer lesion lengths and a higher prevalence of chronic total occlusions. Kaplan-Meier analysis demonstrated significantly higher primary patency in the BP group compared with the EVT group at 12 months (86.9% vs 71.4%, log-rank p=0.018) and 24 months (78.1% vs 58.2%, log-rank p=0.009). Target lesion revascularization occurred in 7 patients (7.1%) in the EVT group and 4 patients (5.7%) in the BP group (RR=1.25; 95% CI 0.38-4.07). Major amputation occurred in 9 patients (9.2%) in the EVT group and 7 patients (10.0%) in the BP group (RR=0.92; 95% CI 0.36-2.35). In multivariable analysis, BP was independently associated with reduced risk of primary patency loss (HR=0.58; 95% CI 0.35-0.94; p = 0.028).Conclusion: In patients with complex FP disease, BP was associated with higher mid-term primary patency compared with EVT, while limb-related outcomes remained comparable between strategies.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapse rates and associated factors in patients with schizophrenia: a retrospective study from Brcko District, Bosnia and Herzegovina. 精神分裂症患者的复发率及相关因素：来自波斯尼亚和黑塞哥维那Brcko区的回顾性研究

Medicinski Glasnik Pub Date : 2026-07-21 DOI: 10.17392/medglas-2172-23-2

Sadina Osmanovic, Rusmir Softic, Jasmina Klebic, Aida Sehanovic

{"title":"Relapse rates and associated factors in patients with schizophrenia: a retrospective study from Brcko District, Bosnia and Herzegovina.","authors":"Sadina Osmanovic, Rusmir Softic, Jasmina Klebic, Aida Sehanovic","doi":"10.17392/medglas-2172-23-2","DOIUrl":"10.17392/medglas-2172-23-2","url":null,"abstract":"Aim: To determine the proportion of patients with recorded psychiatric rehospitalisation within one year and examine crude associations with antipsychotic treatment patterns and documented medication adherence.Methods: This retrospective cohort study included 87 patients with International Classification of Diseases, 10th Revision schizophrenia (F20.0-F20.9) hospitalised in Brčko District during 2014-2018 and with documented 12-month follow-up. Relapse was defined as recorded psychiatric rehospitalisation due to worsening psychotic symptoms. A separate audit described discharge treatment in 236 hospitalisation records. Exact tests and crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.Results: Recorded rehospitalisation occurred in 32/87 patients (36.8%). First-generation antipsychotic exposure (OR 2.11, 95% CI 0.74-6.03; p = 0.215) and antipsychotic polypharmacy (OR 2.16, 95% CI 0.82-5.65; p = 0.164) were not significantly associated with rehospitalisation. Medication non-adherence (OR 11.33, 95% CI 3.58-35.87; p < 0.001) and documented non-cooperation (OR 10.00, 95% CI 3.16-31.62; p < 0.001) showed strong crude associations. In the audit, treatment was identifiable in 183/236 records; polypharmacy was documented in 73.8% and long-acting injectable/depot use in 32.8%.Conclusion: Documented non-adherence and non-cooperation were strongly associated with recorded rehospitalisation. The findings support structured adherence assessment and post-discharge follow-up but do not establish causal effects of antipsychotic class or regimen complexity.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial stiffness parameters during six-month antihypertensive therapy: a prospective observational study. 6个月抗高血压治疗期间动脉僵硬参数：一项前瞻性观察研究。

Medicinski Glasnik Pub Date : 2026-07-21 DOI: 10.17392/medglas-2173-23-2

Almin Handanagic, Sekib Sokolovic, Ekrema Mujaric

{"title":"Arterial stiffness parameters during six-month antihypertensive therapy: a prospective observational study.","authors":"Almin Handanagic, Sekib Sokolovic, Ekrema Mujaric","doi":"10.17392/medglas-2173-23-2","DOIUrl":"10.17392/medglas-2173-23-2","url":null,"abstract":"Aim: To investigate the prevalence of arterial stiffness in hypertensive patients in Bosnia and Herzegovina and to assess the effects of various antihypertensive therapies on arterial stiffness.Methods: This prospective, open-label clinical study enrolled 200 patients who met predefined inclusion criteria from a total of 217 screened between 1 November 2023 and 30 April 2024. Participants were followed for six months. Thirteen distinct antihypertensive treatment combinations were evaluated.Results: In 200 patients, six months of antihypertensive treatment significantly reduced systolic blood pressure from 136.06 ± 15 to 130.69 ± 12 mmHg and diastolic blood pressure from 85.35±9 to 82.69±7 mmHg. Pulse wave velocity (PWV) changed only minimally, from 8.09±1.5 m/s to 8.05±1.2 m/s (p=0.354). Augmentation index (AIx) improved from 25.17% to 23.33%. The greatest reduction in PWV was observed with angiotensin-converting enzyme inhibitors plus statins (-0.19 m/s), while the largest reduction in AIx was seen with angiotensin-converting enzyme inhibitors, calcium channel blockers, beta blockers, diuretics, and statins (-15.64%, p<0.001). Baseline systolic blood pressure was the strongest, although weak, predictor of pulse wave velocity reduction (AUC=0.627, p=0.002).Conclusion: The study demonstrated a high prevalence of increased arterial stiffness among hypertensive patients, with higher values associated with greater cardiovascular risk. Routine assessment of arterial stiffness, alongside standard blood pressure measurement, may improve cardiovascular risk stratification and support more effective, individualized hypertension management.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0