Medicinski Glasnik最新文献

{"title":"Subclinical systolic left ventricular dysfunction in patients with non-significant coronary artery stenosis detected by coronary computed tomography (CT) angiography.","authors":"Edin Begic, Ada Djozic, Nejra Mlaco-Vrazalic, Emina Nesimi, Akif Mlačo, Bojan Stanetic, Tamara Kovacevic-Preradovic, Miodrag Ostojic","doi":"10.17392/medglas-2199-23-2","DOIUrl":"10.17392/medglas-2199-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the relationship between coronary artery calcium (CAC) score and left ventricular global longitudinal strain (LV GLS) in patients with arterial hypertension who had a negative treadmill exercise stress test but mild to intermediate coronary stenosis on coronary computed tomography angiography (CCTA).</p><p><strong>Methods: </strong>A total of 53 hypertensive patients (mean age 54.8 ± 4.8 years; 50.9% male) with 30-50% coronary stenosis on CCTA were included. Patients with diabetes, malignancy, or established coronary/peripheral artery disease were excluded. CAC score, left ventricular ejection fraction (LVEF, Simpson's method), and LV GLS (speckle-tracking echocardiography) were measured. Groups were stratified by GLS (< 18.5% vs. ≥ 18.5%) and LVEF (< 60% vs. ≥ 60%), and CAC score differences were assessed using the Mann-Whitney U test.</p><p><strong>Results: </strong>The median CAC score was 27 (IQR 16-44.5), median LVEF 60% (IQR 58-63%), and mean GLS 19.37 ± 0.89%. No overall association was found between CAC score and LV function by LVEF or GLS. In patients with left anterior descending (LAD) stenosis (30-50%), reduced LV function was linked to significantly higher CAC score. Median CAC score was higher in patients with GLS ≤ 18.5% (157 vs. 44.5; p = 0.019) and LVEF <60% (157 vs. 44.5; p = 0.019). No significant associations were found in right coronary artery (RCA), circumflex artery (Cx), or three-vessel stenosis subgroups.</p><p><strong>Conclusion: </strong>Higher CAC score in hypertensive patients with mild LAD stenosis and negative stress testing identify those at risk of subclinical LV dysfunction.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of topically applied diclofenac, ketoprofen, and piroxicam on interleukin-17, signal transducer and activator of transcription 3, and prostaglandin E2 levels in a rat model of collagen-induced arthritis.","authors":"Sanita Maleskic Kapo, Lejla Burnazovic Ristic, Emina Dervisevic, Nina Čamdžić, Branislava Teofilovic, Enisa Hodžić, Maida Rakanovic-Todic","doi":"10.17392/medglas-2187-23-2","DOIUrl":"10.17392/medglas-2187-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate and compare the effects of topically applied diclofenac, ketoprofen, and piroxicam on key inflammatory mediators, including interleukin-17 (IL-17), prostaglandin E2 (PGE2), and signal transducer and activator of transcription 3 (STAT3), in a rat model of collagen-induced arthritis (CIA).</p><p><strong>Methods: </strong>Thirty male Wistar rats were assigned to five groups: three experimental groups receiving topical diclofenac, ketoprofen, or piroxicam, respectively, a positive control group receiving a placebo patch, and a negative control group without collagen injection. CIA was induced using bovine type II collagen and incomplete Freund's adjuvant, with arthritis severity assessed through macroscopic scoring. NSAID patches were applied to the right hind paw for 6 hours daily over 5 days. Immunological parameters were quantified via enzyme-linked immunosorbent assay (ELISA). Statistical analysis included ANOVA, Kruskal-Wallis, and mixed-effects models to evaluate drug effects over time.</p><p><strong>Results: </strong>A significant difference was observed in tissue PGE₂ levels (F(4,25) = 4.235; p=0.009; η² = 0.404), with diclofenac showing significantly lower values compared to the negative control and ketoprofen groups, while no significant differences were found for IL-17 or STAT3.</p><p><strong>Conclusion: </strong>Topical NSAIDs demonstrated selective anti-inflammatory effects, primarily through significant suppression of tissue PGE₂, confirming effective local COX pathway inhibition. The absence of significant changes in IL-17 and STAT3 suggests that short-term topical therapy mainly targets prostaglandin-mediated inflammation rather than upstream cytokine or transcriptional pathways involved in rheumatoid arthritis pathogenesis, warranting further investigation into their long-term therapeutic benefits.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local versus general anaesthesia for open inguinal hernia repair: a retrospective cohort study of postoperative complications and patient-reported outcomes.","authors":"Amir Tursunović, Kenana Ljuca, Emir Bećirović, Minela Bećirović, Nadina Ljuca, Jasminka Mujkanović, Bahrudin Hadžiefendić","doi":"10.17392/medglas-2184-23-2","DOIUrl":"10.17392/medglas-2184-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To compare outcomes of elective open inguinal hernia repair under local anaesthesia (LA) and general anaesthesia (GA).</p><p><strong>Methods: </strong>This retrospective cohort included 833 adults treated in Tuzla during 2017-2025. The primary outcome was any early adverse outcome within 30 days. Secondary outcomes included analgesic requirement, chronic groin pain, discomfort, dissatisfaction, and recurrence. Logistic regression adjusted for age, American Society of Anesthesiologists physical status, hernia characteristics, and technique. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were reported; Benjamini-Hochberg correction was applied to secondary outcomes.</p><p><strong>Results: </strong>The LA group included 425 patients and the GA group 408. Postoperative analgesia was required in 338 (79.5%) and 110 (27.0%) patients, respectively (p<0.001). An early adverse outcome occurred in 79 (18.6%) and 35 (8.6%) patients (aOR 2.08, 95% CI 1.31-3.30; p = 0.002), mainly because of more haematomas with LA, 54 (12.7%) versus 20 (4.9%) (p < 0.001). Chronic groin pain did not differ after adjustment (aOR 1.26, 95% CI 0.81-1.96; p = 0.310). Dissatisfaction was higher with LA, 85 (20.8%) versus 40 (10.1%) (aOR 1.95, 95% CI 1.27-2.99; p = 0.002). Eight recurrences were recorded. Median follow-up was 14 months (interquartile range 12-18 months).</p><p><strong>Conclusion: </strong>LA was associated with more early adverse outcomes and dissatisfaction than GA. Chronic pain did not differ after adjustment, and recurrence was similar. Selection bias and residual confounding should be considered.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the CHA₂DS₂-VASc Score for cardiovascular mortality in NSTEMI patients with echocardiographic correlates.","authors":"Minela Becirovic, Emir Becirovic, Amir Becirovic, Semir Hadzic, Admir Abdic, Elma Mujaković, Emir Begagić, Kenana Ljuca, Anesa Terzic, Ekrema Mujaric, Nadina Ljuca","doi":"10.17392/medglas-2198-23-2","DOIUrl":"10.17392/medglas-2198-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the prognostic value of the CHA₂DS₂-VASc score in relation to major adverse cardiovascular events (MACE) and cardiovascular mortality in patients with non-ST elevation myocardial infarction (NSTEMI), and to assess its association with clinical and echocardiographic characteristics.</p><p><strong>Methods: </strong>This prospective, observational, cohort study included 311 NSTEMI patients admitted to the Internal Medicine Clinic at the University Clinical Centre Tuzla between January 2023 and April 2024. The patients were stratified into intermediate-risk (score < 4) and high-risk (score ≥ 4) groups based on the CHA₂DS₂-VASc score at admission. Demographic, clinical, and echocardiographic data were collected, including electrocardiography (ECG) and transthoracic echocardiography. All patients were followed for 3 months (90 days) to assess the occurrence of MACE and cardiovascular mortality.</p><p><strong>Results: </strong>The patients in the high-risk group were older and had significantly lower left ventricular ejection fractions and larger left atrial diameters compared with the intermediate-risk group. During the 3-month follow-up, MACE occurred in 11.9% of high-risk and 3.9% of intermediate-risk patients; cardiovascular mortality was observed exclusively in the high-risk group (2.5%). A higher CHA₂DS₂-VASc score was significantly associated with cardiovascular mortality (p = 0.003), but not with overall MACE (p = 0.393). Moderate predictive accuracy for mortality (AUC = 0.64) and shorter event-free survival in the high-risk group (log-rank p = 0.005) were observed.</p><p><strong>Conclusion: </strong>The CHA₂DS₂-VASc score showed potential as a simple and accessible tool for early identification of NSTEMI patients at risk of cardiovascular death. Its significant association with mortality supports its role as a supplementary risk stratification tool, although these findings require validation in larger, multicentre studies.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of fatigue in patients with rheumatoid arthritis using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale.","authors":"Melika Salihović Jahić, Maida Skokić, Nadina Kurtanović, Alma Serak Tokic, Amra Tulumović Mešanović, Emir Bećirović, Minela Bećirović, Alisa Imamović, Halima Bajrektarević, Naid Dizdarević, Nihada Čerkezović","doi":"10.17392/medglas-2190-23-2","DOIUrl":"10.17392/medglas-2190-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To assess fatigue severity in patients with rheumatoid arthritis (RA) using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale and to examine its association with demographic, socioeconomic, clinical, and lifestyle-related factors.</p><p><strong>Methods: </strong>This cross-sectional observational study included 90 adults with RA. Fatigue was assessed using the FACIT-F scale, and disease activity was assessed using the Disease Activity Score in 28 joints (DAS28). Continuous variables were summarised as medians and interquartile ranges (IQRs). Associations were evaluated using Spearman correlation, Mann-Whitney U, Kruskal-Wallis, and robust linear regression analyses.</p><p><strong>Results: </strong>The median FACIT-F score was 37.0 [IQR 27.0 - 45.0], and 35.6% of patients had moderate-to-severe fatigue. FACIT-F correlated negatively with DAS28 (ρ = -0.381; p < 0.001). In multivariable robust regression, DAS28 remained associated with FACIT-F score after adjustment for age and disease duration (β = -3.54; 95% confidence interval -5.39 to -1.68; p < 0.001), whereas age and disease duration were not significant. FACIT-F scores differed by sex and employment status but not by treatment category.</p><p><strong>Conclusion: </strong>Fatigue is a prevalent and clinically important symptom in RA. Higher disease activity was associated with greater fatigue severity, supporting comprehensive assessment of fatigue beyond inflammatory disease activity alone.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-lymphocyte ratio and metabolic syndrome in patients with schizophrenia spectrum disorders.","authors":"Sunčica Humačkić, Marko Pavlović, Martina Krešić Ćorić, Ivana Sušac","doi":"10.17392/medglas-2197-23-2","DOIUrl":"10.17392/medglas-2197-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the differences in neutrophil-to-lymphocyte ratio (NLR) between patients with schizophrenia spectrum disorders (SSD) and healthy controls, and their association with metabolic syndrome (MS) in SSD patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 70 SSD patients and 55 healthy controls. NLR was calculated using absolute neutrophil and lymphocyte counts (WBC) after obtaining complete blood counts. MS was diagnosed using ATP III criteria, and SSD patients were divided into two subgroups with and without MS.</p><p><strong>Results: </strong>Patients with SSD had significantly higher total WBC (p = 0.001), as well as neutrophil counts and NLR (both p 0.05).</p><p><strong>Conclusion: </strong>The findings suggest that inflammation, as indicated by elevated NLR, is linked to SSD independent of MS.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining kidney function before and after kidney donation in living kidney donors: single-centre experience.","authors":"Mirha Pjanić, Mirna Alečković-Halilović, Edin Zukić, Alma Klapić, Naida Morić, Ivana Čerkez, Amila Jašarević, Mirela Bašić-Denjagić, Selma Hodžić, Maida Dugonjić-Taletović, Belkisa Izić, Maja Sulejmanović","doi":"10.17392/medglas-2186-23-2","DOIUrl":"10.17392/medglas-2186-23-2","url":null,"abstract":"<p><strong>Aim: </strong>The most common type of kidney transplantation in Bosnia and Herzegovina is from living donors, but there is a lack of published data on glomerular filtration rate (GFR) values and kidney outcomes in living kidney donors. This study aimed to evaluate the safety of living kidney donation at our centre.</p><p><strong>Methods: </strong>One hundred and seventy living kidney donors at the University Clinical Centre Tuzla were analysed. Initially, there were 170 participants; however, only 31 provided all the required medical data and completed the study. GFR was estimated (eGFR) using the CKD-EPI and MDRD formulas, and a web-based calculator was used to predict GFR > 90 ml/min/1.73 m², along with measurement of creatinine clearance (CrCl). Measured GFR (mGFR) was assessed through technetium-99m diethylene triamine pentaacetic acid (DTPA) renogram, with follow-up visits to estimate post-donation GFR.</p><p><strong>Results: </strong>The CKD-EPI, MDRD, and web-based application showed similar diagnostic performances, with MDRD and CKD-EPI systematically underestimating mGFR. CrCl demonstrated strong diagnostic performance. Follow-up visits showed that most donors had post-donation eGFR values between 45 and 89 mL/min/1.73 m², with none progressing to pre-dialysis or the dialysis stage after kidney donation.</p><p><strong>Conclusion: </strong>CrCl demonstrated strong diagnostic performance in our study population, and the DTPA renogram reliably assessed kidney function. Post-donation eGFR levels were satisfactory, indicating that our diagnostic workup for potential living kidney donors in our centre is safe and effective.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric profile of the lumbar spine in the Indonesian population: vertebral body, pedicle, canal, and foramen dimensions.","authors":"Andhika Yudistira, Respati Suryanto Dradjat, Edi Mustamsir, Moch Agus Choiron, Yuyun Yueniwati, Hidayat Sujuti, I Ketut Suyasa","doi":"10.17392/medglas-2188-23-2","DOIUrl":"10.17392/medglas-2188-23-2","url":null,"abstract":"<p><strong>Aim: </strong>The lumbar spine is vital for supporting body weight and facilitating trunk mobility. Morphometric data of the lumbar spine in Southeast Asian populations, particularly the Indonesian population, remain limited. This study aimed to provide baseline morphometric parameters of the lumbar spine in Indonesia to enhance preoperative planning and surgical outcome.</p><p><strong>Methods: </strong>This descriptive study analysed 150 adult patients (ages 17-55) who underwent CT scans at Dr. Saiful Anwar General Hospital in Malang between 2021 and 2023. Lumbar spine parameters, including vertebral body dimensions, pedicle morphometry, spinal canal diameter, intervertebral foramen size, and segmental height, were measured by independent, trained observers to minimize inter-observer variability. Data were extracted from the hospital's Radiology Information System (RIS).</p><p><strong>Results: </strong>The mean vertebral body height (29.14 mm) and width (42.17 mm) were smaller than those reported in Western populations, but consistent with Indonesian data. The mean pedicle width at L3 was 10.78 mm, and the spinal canal diameter (13.9 mm) was narrower than in Western populations but similar to East Asian and Indian cohorts. These findings highlight anatomical differences that should be considered in spinal surgery, including implant sizing and preoperative planning.</p><p><strong>Conclusion: </strong>This study provides essential baseline lumbar spine morphometric data for the Indonesian population. The results emphasize the need for region-specific surgical approaches. Future studies with larger, diverse samples are recommended to refine these findings and enhance clinical applications.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable bowel syndrome-related symptoms among medical students in Bosnia and Herzegovina.","authors":"Amina Džidić-Krivić, Benjamin Dizdarević, Almir Mešanović, Jasna Kusturica, Emir Bećirović, Amir Bećirović, Minela Bećirović, Harisa Hibić Kaknjašević, Semir Hadžić, Emir Begagić, Sanel Suljić, Samra Kadić Vukas, Lejla Tandir Lihić","doi":"10.17392/medglas-2191-23-2","DOIUrl":"10.17392/medglas-2191-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To determine the prevalence of irritable bowel syndrome (IBS)-related symptoms and associated factors among medical students in Bosnia and Herzegovina.</p><p><strong>Methods: </strong>This cross-sectional online survey included 176 medical students from the universities of Sarajevo and Zenica between November 2022 and December 2023. IBS-related symptoms were assessed using the Serbian-language Rome III questionnaire, and test anxiety using the Westside Test Anxiety Scale. Categorical variables were compared using Pearson's χ² test.</p><p><strong>Results: </strong>Eighty-four students (47.7%) met the symptom-based Rome III criteria. The IBS-related symptoms group included 75 females (89.3%) compared with 54 (58.7%) in the comparison group (p<0.001). Sweets consumption at least four times weekly was reported by 53 (63.1%) and 45 (48.9%) students, respectively (p = 0.021). Test-anxiety distributions differed between groups (p < 0.001); extremely high anxiety was reported by 12 (14.3%) students with IBS-related symptoms and one (1.1%) without symptoms. Other sociodemographic and lifestyle characteristics were not associated with IBS-related symptoms.</p><p><strong>Conclusion: </strong>IBS-related symptoms were frequent in this medical-student sample and were associated with female sex, frequent sweets consumption, and test anxiety. The cross-sectional, self-reported design precludes causal interpretation and clinical confirmation of IBS.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell distribution width-to-platelet ratio (RPR) as a simple non-invasive predictor of liver cirrhosis in patients with chronic hepatitis B: a cross-sectional study.","authors":"Angelina Yuwono, Taufik Sungkar, Ilhamd Ilhamd","doi":"10.17392/medglas-2196-23-2","DOIUrl":"10.17392/medglas-2196-23-2","url":null,"abstract":"<p><strong>Aim: </strong>Chronic hepatitis B (CHB) is a major cause of liver cirrhosis worldwide. This study aimed to evaluate the red cell distribution width-to-platelet ratio (RPR) as a simple non-invasive predictor of cirrhosis in CHB patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 221 CHB patients at H. Adam Malik General Hospital, Medan, Indonesia (May 2024-May 2025). Cirrhosis was diagnosed by FibroScan (≥ 14 kPa) or ultrasonography findings. RPR was calculated from routine haematology data. Bivariate analysis was used to compare the cirrhotic and non-cirrhotic groups. ROC curve analysis was used to evaluate the diagnostic accuracy of RPR and determine the optimal cut-off values in terms of sensitivity and specificity.</p><p><strong>Results: </strong>Of 221 patients, 64 (29.0%) had cirrhosis. Cirrhotic patients were older (54.5 vs. 48 years; p = 0.001) and predominantly male (77.6% vs. 56.1%; p = 0.004). RPR was significantly higher in the cirrhotic group (0.16 vs. 0.05; p < 0.001). ROC analysis showed that RPR had an AUC of 0.938 (95% CI: 0.906-0.970; p < 0.001), with an optimal cut-off value of 0.085, yielding sensitivity of 87.5% and specificity of 87.3% for detecting cirrhosis.</p><p><strong>Conclusion: </strong>RPR is a simple, inexpensive, and widely available haematological index with excellent diagnostic accuracy for predicting cirrhosis in CHB patients. It may serve as an effective screening tool in settings with limited access to advanced diagnostic modalities.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}