Medicinski Glasnik最新文献

{"title":"Decoding the gut-brain axis in irritable bowel syndrome: a cross-sectional analysis of anxiety and depression symptoms in constipation and diarrhoea predominant subtypes.","authors":"Syifa Mustika, Afina Fitra Firdaus, Arlentina Bentivolia Simamora, Amalia Nurul Hatinah, Hamzah Shatri","doi":"10.17392/medglas-2200-23-2","DOIUrl":"10.17392/medglas-2200-23-2","url":null,"abstract":"<p><strong>Aim: </strong>The gut-brain axis is pivotal in the pathophysiology of irritable bowel syndrome (IBS), with anxiety, depression and quality of life. IBS-C (constipation-predominant) and IBS-D (diarrhoea-predominant) are frequently linked with psychological comorbidities. Neither in Indonesia nor globally has research been conducted regarding the relationship between subtypes of IBS and depression and anxiety. This study aimed to identify the relationship between depression and anxiety and subtypes of IBS.</p><p><strong>Methods: </strong>From January to December 2023, a cross-sectional study was conducted on 49 IBS patients at Dr Saiful Anwar General Hospital, Indonesia. Demographic data and colonoscopy reports were gathered. Psychological status was measured using the Hospital Anxiety and Depression Scale (HADS). The χ² test and Spearman's correlation analysis were performed to examine associations between demographic characteristics, IBS subtype, and psychological scores.</p><p><strong>Results: </strong>There were no significant associations between sex, age, or IBS subtype and the presence of anxiety or depression symptoms. Anxiety and depression scores were modestly correlated overall (r = 0.503; p = 0.000). Subgroup analysis revealed a strong correlation in IBS-C (r = 0.613; p = 0.009) and a moderate correlation in IBS-D (r = 0.461; p = 0.008), indicating a notable interrelationship within these subtypes.</p><p><strong>Conclusion: </strong>Moderate relationship between anxiety and depression was found in IBS patients, strongest in IBS-C and moderate in IBS-D. Neither demographics nor IBS subtype was significantly related to psychological symptoms independently. The findings warrant routine screening for mental health and multidisciplinary management in IBS patient.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-6 is not associated with postoperative intra-abdominal adhesion severity in a rat model.","authors":"Ali Gavrankapetanovic, Amina Valjevac, Amela Dervisevic, Lejla Alic, Sead Ibrahimovic, Adis Kukuljac, Emina Letić","doi":"10.17392/medglas-2185-23-2","DOIUrl":"10.17392/medglas-2185-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To assess whether serum interleukin-6 (IL-6) measured on postoperative day 14 reflects adhesion severity and to compare intraperitoneal alteplase, N-acetylcysteine (NAC), and combined treatment.</p><p><strong>Methods: </strong>In this exploratory randomised study, 40 male Wistar rats were allocated to untreated adhesion, alteplase, NAC, alteplase plus NAC, or sham groups (n = 8 per group). Serum IL-6 and macroscopic adhesion grade were assessed on day 14. Group differences were analysed using the Kruskal-Wallis tests followed by Benjamini-Hochberg-adjusted Dunn comparisons; associations were assessed using Spearman correlation.</p><p><strong>Results: </strong>Serum IL-6 differed among groups (H = 18.08; p = 0.001). Median serum IL-6 concentrations were 14.52 pg/mL (IQR 9.91-19.13) in untreated animals, 30.70 pg/mL (IQR 27.31-34.09) after alteplase (p = 0.003), 24.95 pg/mL (IQR 17.48-32.42) after NAC (p = 0.037), 30.76 pg/mL (IQR 24.16-37.36) after combined treatment (p = 0.007), and 18.36 pg/mL (IQR 11.49-25.23) in sham animals (p = 0.320). Adhesion grades differed (H = 20.80; p < 0.001) and were lower after alteplase and combined treatment (both p = 0.041); the NAC comparison was not significant (p = 0.054). Serum IL-6 was not correlated with adhesion grade (ρ = -0.131; 95% CI -0.425 to 0.189; p = 0.422).</p><p><strong>Conclusion: </strong>A single serum IL-6 measurement on day 14 did not reflect adhesion severity. Serial serum measurements and concurrent peritoneal or tissue biomarkers may be more informative.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effects of heat-not-burn tobacco product use on cardiorespiratory symptoms in adults.","authors":"Aida Mujaković, Mihana Hasak Hassan, Besim Prnjavorac, Nejra Mlaco-Vrazalic, Akif Mlačo","doi":"10.17392/medglas-2193-23-2","DOIUrl":"10.17392/medglas-2193-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To determine if heat-not-burn (HNB) tobacco products are a safe alternative to cigarette smoking by inducing decreased decline of cardiorespiratory function.</p><p><strong>Methods: </strong>A clinical observational, cross-sectional study was conducted in the period between February and June 2025. It analysed and identified the effects of HNB tobacco products on cardiorespiratory symptoms in 60 adults below 55 years of age with confirmed arterial hypertension, 30 in the HNB users group (≥ 6 months of HNB use and no history of conventional cigarette use (CCU)), and 30 in the non-HNB user group (no history of HNB or CCU).</p><p><strong>Results: </strong>The gender distribution among the groups was similar. HNB tobacco product users reported significantly more respiratory (daily and nighttime shortness of breath, coughing) and cardiologic symptoms (choking, shortness of breath during physical activity). The following parameters were significantly reduced in the HNB tobacco product users: forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 75% (FEF75) (p = 0.01), SO₂ (p < 0.001), pO₂ (p = 0.001), HCO₃^- (p < 0.001), total cholesterol (p = 0.001), and basophils (p < 0.001), while the following parameters were significantly increased in the same group: right ventricular systolic pressure (RVSP) (p = 0.002), hsCRP (p < 0.001), monocytes (p < 0.001), eosinophils (p < 0.001), D-dimer (p < 0.001), and platelet count (p = 0.003).</p><p><strong>Conclusion: </strong>HNB tobacco product use in adults with arterial hypertension was associated with worse cardiorespiratory symptoms, impaired pulmonary function, signs of early right ventricular dysfunction, and systemic inflammation.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant differences in volatile organic compounds and interleukin-12 (IL-12) serum levels between lung cancer patients and healthy controls: a cross-sectional study.","authors":"Marsha Nurandhini, Ungky Agus Setyawan, Aditya Sri Listyoko, Susanthy Djajalaksana, Arinto Yudi Ponco Wardoyo","doi":"10.17392/medglas-2189-23-2","DOIUrl":"10.17392/medglas-2189-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To explore differences in exhaled volatile organic compounds (VOCs) and serum interleukin-12 (IL-12) levels between lung cancer patients and healthy controls, and their potential relationship with tumour-related metabolic and systemic immune alterations.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving lung cancer patients and healthy controls. Exhaled breath samples were analysed using the µβreath sensor to quantify VOCs, including total volatile organic compounds (TVOC)(1), TVOC(2), acetone, formaldehyde, toluene, hexane, and methane. Serum IL-12 levels were measured via ELISA. Significant limitations such as age mismatch, unvalidated sensor data, and potential confounders (smoking, chemotherapy, diet, environmental VOCs) were acknowledged.</p><p><strong>Results: </strong>Lung cancer patients exhibited significantly higher TVOC(1) and TVOC(2) levels, and higher acetone levels, while formaldehyde, toluene, hexane, and methane levels were lower than in controls. Serum IL-12 levels were markedly lower in patients, reflecting systemic immune modulation rather than direct diagnostic specificity. ROC analysis indicated high sensitivity for certain VOCs, but specificity remained limited, suggesting that these markers were exploratory rather than definitive diagnostic tools. No significant correlation was observed between VOCs and IL-12 levels.</p><p><strong>Conclusion: </strong>Differences in exhaled VOC profiles and serum IL-12 levels provide preliminary insight into tumour-related metabolic and immune alterations in lung cancer. However, due to major methodological limitations, particularly age mismatch and incomplete sensor validation, these findings should be interpreted with caution. Exhaled VOCs and IL-12 should be considered hypothesis-generating exploratory biomarkers that require validation in larger, age-matched cohorts using gold-standard analytical techniques and multivariate modelling.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B7-H3 expression reflects magnetic resonance imaging (MRI)-derived tumour burden and peritumoral brain oedema in adult gliomas: a radiopathological correlation study.","authors":"Fatima Juković-Bihorac, Emir Begagić, Slaviša Đuričić, Alma Efendić, Semir Vranić","doi":"10.17392/medglas-2192-23-2","DOIUrl":"10.17392/medglas-2192-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To determine whether immunohistochemical B7-H3 expression is associated with magnetic resonance imaging (MRI)-derived tumour volume, peritumoral brain oedema volume, and oedema index in adult gliomas.</p><p><strong>Methods: </strong>This retrospective radiopathological correlation study included 99 consecutive patients with histopathologically confirmed intracranial gliomas surgically treated between 2013 and 2021. B7-H3 expression (clone RBT-B7H3, Bio SB, USA) was evaluated using staining intensity, percentage of positive tumour cells, and a composite immunoreactive score (IRS). Tumour volume (TV), peritumoral brain oedema volume (PTBE), and oedema index (EI) were calculated from orthogonal MRI measurements. Spearman correlation and crude and adjusted linear regression were used. Adjusted models included age, sex, tumour grade, and Ki-67.</p><p><strong>Results: </strong>Median TV was 29.31 cm³ (IQR 12.17-49.12), median PTBE was 84.51 cm³ (IQR 47.59-178.18), and median EI was 4.56 (IQR 3.83-5.00). B7-H3 IRS correlated strongly with TV (r = 0.921, p < 0.001) and PTBE (r = 0.920, p < 0.001), but not with EI (r = -0.105, p = 0.299). After adjustment, B7-H3 IRS remained associated with ln(TV) (beta = 0.228, 95% CI 0.190-0.265, p < 0.001) and ln(PTBE) (beta = 0.178, 95% CI 0.152-0.204, p < 0.001), but not with EI (beta = 0.001, 95% CI -0.083 to 0.084, p = 0.990).</p><p><strong>Conclusion: </strong>B7-H3 expression is independently associated with MRI-derived tumour volume and peritumoral brain oedema volume in adult gliomas, but not with oedema index, supporting its relationship with absolute MRI-visible lesion burden.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of demographic and clinical characteristics of patients with chronic renal failure in Mosul City, Iraq.","authors":"Farah Mohammed Ghazal, Duaa Al-Nafoly","doi":"10.17392/medglas-2195-23-2","DOIUrl":"10.17392/medglas-2195-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To assess demographic and clinical determinants of CKD among patients undergoing haemodialysis in Mosul, Iraq.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted at a public dialysis centre in Mosul between January and April 2024. A total of 89 patients with confirmed CKD were recruited using purposive sampling. Data were obtained through structured interviews and medical records, including demographic characteristics, etiological factors, CKD stage based on KDIGO criteria, and biochemical indicators (serum creatinine and blood urea nitrogen). Associations between CKD stage and demographic or clinical variables were assessed using chi-square tests. Multivariate logistic regression was applied to identify independent predictors of advanced CKD (stages 4-5), with results expressed as odds ratios and 95% confidence intervals.</p><p><strong>Results: </strong>Diabetes mellitus (27 %) and hypertension (23.6 %) were the leading aetiologies. End-stage kidney disease (ESRD) represented 48.3 % of cases. Male prevalence increased across CKD stages, from 44.4% in mild to 67.4% in ESRD (p = 0.031). Mean creatinine rose from 1.6 ± 0.3 mg/dL in mild CKD to 8.5 ± 2.3 mg/dL in ESRD, with corresponding blood urea nitrogen (BUN) increases from 22.5 ± 5.2 to 89.6 ± 15.1 mg/dL. Overall, 71.9% presented in severe or ESRD stages, reflecting late diagnosis. Multivariate analysis confirmed male sex as an independent predictor of advanced CKD (OR = 2.14; 95% CI: 1.05-4.36; p = 0.031).</p><p><strong>Conclusion: </strong>CKD in Mosul is characterized by late-stage presentation and predominance of metabolic aetiologies. Male sex emerged as an independent predictor of advanced CKD. These findings highlight the need for targeted screening, earlier detection, and improved nephrology services in post-conflict communities.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence agitation in adults undergoing abdominal surgery under general anaesthesia: predictors from a two-centre prospective observational study.","authors":"Mirza Kovacevic, Amir Hakanovic, Alma Jahic, Ismeta Karic Heric, Selma Sijercic, Ferid Krupic","doi":"10.17392/medglas-2194-23-2","DOIUrl":"10.17392/medglas-2194-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To identify factors associated with emergence agitation (EA) in adults undergoing abdominal surgery under general anaesthesia.</p><p><strong>Methods: </strong>This prospective two-centered study included 107 patients (≥18 years) who underwent abdominal surgery at two hospital centres between February 2025 and September 2025. Collected variables included demographics, American Society of Anesthesiologists (ASA) classification, education level, smoking and alcohol use, comorbidities, fasting status, urgency and type of surgery, and anaesthesia duration. Hemodynamic parameters were recorded before induction, before endotracheal intubation (ETI), and before extubation. EA was assessed using the Richmond Agitation-Sedation Scale (RASS) and the Sedation-Agitation Scale (SAS) before (T1) and 10 minutes after extubation (T2).</p><p><strong>Results: </strong>At T2, EA incidence was 22% (23 patients) according to SAS and 41% (44 patients) according to RASS. SAS-defined EA at T1 was associated with ASA status ≥ III (aOR 2.35, 95% CI 1.05-5.25; p = 0.028) and lower blood pressure before extubation (aOR 0.62, 95% CI 0.50-0.96; p = 0.016). SAS-defined EA at T2 was associated with higher body weight (aOR 1.20, 95% CI 1.03-1.40; p = 0.017) and higher heart rate before extubation (aOR 1.45, 95% CI 1.25-1.80; p = 0.022). According to RASS, lower blood pressure before induction was associated with EA at T1 (aOR 0.88, 95% CI 0.78-0.99; p = 0.045), while nasogastric tube presence was associated with EA at T2 (aOR 2.10, 95% CI 1.06-4.15; p = 0.034).</p><p><strong>Conclusion: </strong>EA after general anaesthesia in adults undergoing abdominal surgery is common. Identification of associated factors may improve perioperative risk assessment and early recognition.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical <i>Centella asiatica</i> gel enhances tissue repair and attenuates inflammation in diabetic wounds: an experimental study in male Wistar rats.","authors":"Eko Setiawan, Dimas Irfan Nabih, Farhan Arifendy Rahman, Hasan Syarief","doi":"10.17392/medglas-2181-23-2","DOIUrl":"10.17392/medglas-2181-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effects of topical <i>Centella asiatica</i> extract gel on early healing of diabetic excision wounds.</p><p><strong>Methods: </strong>A randomised, post-test-only in vivo experiment included 28 male Wistar rats with nicotinamide/streptozotocin-induced diabetes and dorsal excision wounds. Rats were assigned to base gel, 0.1% gentamicin, 10% <i>C. asiatica</i> gel, or 20% <i>C. asiatica</i> gel (n = 7 per group) for seven days. Epithelial thickness, fibroblast counts, collagen deposition, angiogenesis, inflammation score, and serum C-reactive protein (CRP) were assessed on day eight. Data were analysed using one-way analysis of variance with post hoc testing and Holm adjustment.</p><p><strong>Results: </strong>Between-group differences were significant for epithelial thickness (p = 0.044), fibroblast counts (p = 0.020), CRP levels (p = 0.002), collagen deposition (p = 0.007), angiogenesis (p < 0.001), and inflammation score (p = 0.009), and all remained significant after Holm adjustment. The 10% C. asiatica gel group showed the highest epithelial thickness, fibroblast count, and collagen deposition, whereas the 20% <i>C. asiatica</i> gel group showed the lowest CRP level and inflammation score and the highest angiogenesis level.</p><p><strong>Conclusion: </strong>Topical <i>C. asiatica</i> gel was associated with favourable changes in selected early histological repair and inflammatory parameters in diabetic excision wounds. The different patterns observed with the 10% and 20% formulations should be interpreted descriptively rather than as evidence of dose-response superiority.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low versus high inferior mesenteric artery ligation and gastrointestinal quality of life following anterior resection for rectal cancer.","authors":"Edin Hodžić, Amila Vinčević Hodžić, Timur Cerić, Zlatan Zvizdić, Amel Hadžimehmedagić","doi":"10.17392/medglas-2182-23-2","DOIUrl":"10.17392/medglas-2182-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To assess whether the level of inferior mesenteric artery (IMA) ligation independently affects gastrointestinal-specific quality of life after anterior resection for rectal cancer.</p><p><strong>Methods: </strong>A prospective cohort study including 125 patients with stage II-III mid- or upper- rectal adenocarcinoma who underwent open anterior resection with total mesorectal excision between 2020 and 2025 was conducted. Patients were classified according to the intraoperative level of IMA ligation as having either low ligation with preservation of the left colic artery (n = 75) or high ligation proximal to the origin of the left colic artery (n = 50). Gastrointestinal Quality of Life Index (GIQLI; range 0-144) was assessed 6-8 weeks after protective stoma closure.</p><p><strong>Results: </strong>GIQLI scores were significantly higher after low IMA ligation compared with high ligation (127.3 ± 5.7 versus 121.6 ± 5.7; p < 0.001). In univariable analysis, high IMA ligation was associated with lower GIQLI scores (B = -5.733; p < 0.001). In multivariable regression analysis excluding the Low Anterior Resection Syndrome (LARS) score, high IMA ligation remained independently associated with lower GIQLI scores (B = -5.016; p < 0.001). In exploratory receiver operating characteristic (ROC) analysis, IMA ligation alone demonstrated moderate discriminatory ability (AUC = 0.689; 95% CI 0.595-0.783), while addition of IMA ligation to established predictors improved model discrimination (AUC=0.790; 95% CI 0.710-0.871).</p><p><strong>Conclusion: </strong>Low IMA ligation was associated with better postoperative gastrointestinal quality of life following anterior resection for rectal cancer. When oncologically appropriate, preservation of the left colic artery may optimise patient-reported outcomes.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-related and clinical predictors of extended recovery after fingertip injury: a single-centre experience.","authors":"Almir Alic, Emir Begagić, Anhel Koluh, Ibrahim Sobo, Savan Kuridža, Mirza Huremović","doi":"10.17392/medglas-2183-23-2","DOIUrl":"10.17392/medglas-2183-23-2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate whether treatment approach and Allen's classification are associated with treatment duration after fingertip injury and to identify predictors of prolonged recovery.</p><p><strong>Methods: </strong>We retrospectively reviewed 91 patients treated for fingertip injuries at Cantonal Hospital Zenica (January 2024 - December 2024). Injuries were classified using Allen's system, and treatment duration was grouped as 7-25, 26-35, or 36-90 days.</p><p><strong>Results: </strong>The cohort was predominantly male (89.0%), with a median age of 47 years (IQR 36-71). Median treatment duration was 24 days (IQR 15-33). Longer treatment duration was associated with exposed distal phalanx (p = 0.016), type 2 diabetes mellitus (p < 0.001), and treatment approach (p < 0.001). In multivariable analysis, osteosynthesis compared with suture (OR 2.95, 95% CI 1.30-12.63) and type 2 diabetes mellitus (OR 3.78, 95% CI 1.22-11.72) were associated with prolonged treatment in exploratory multivariable analysis (36-90 days).</p><p><strong>Conclusion: </strong>Treatment approach and selected comorbidities should be considered alongside injury classification when anticipating recovery duration; however, the findings should be interpreted cautiously because of the limited number of prolonged-treatment events and diabetic patients.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}