Medicinski Glasnik最新文献

{"title":"Metabolic and renal predictors of coronary artery calcification: the independent role of the uric acid/estimated glomerular filtration rate (UA/eGFR) ratio and Castelli indices.","authors":"Zarina Babić Jušić, Mirza Babić, Sabina Prevljak, Emir Bećirović, Fuad Zukić, Minela Bećirović, Amir Bećirović","doi":"10.17392/2006-23-01","DOIUrl":"https://doi.org/10.17392/2006-23-01","url":null,"abstract":"<p><strong>Aim: </strong>To examine the association between metabolic parameters and novel cardiometabolic indices with the coronary artery calcium score (CACS).</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 130 patients who underwent coronary computed tomography angiography (CCTA) at the Radiology Clinic of the Clinical Centre of the University of Sarajevo between January and June 2024. Patients were classified into two groups: those with CACS &le;100 and those with CACS &gt;100. Platelet count, mean platelet volume (MPV), estimated glomerular filtration rate (eGFR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid (UA), and novel cardiometabolic indices, including Castelli risk index I and II (CRI-I and CRI-II), non-high-density lipoprotein cholesterol (non-HDL-C), were compared between the groups.</p><p><strong>Results: </strong>Patients with CACS &gt;100 had significantly higher MPV, TC, LDL-C, UA, non-HDL-C, CRI-I, CRI-II, and the UA/eGFR ratio. Older age, increased platelet activity, dyslipidemia, hyperuricemia, and the higher UA/eGFR ratio correlated positively with CACS, whereas eGFR correlated negatively. In multivariate regression analysis, the UA/eGFR ratio emerged as an independent predictor of higher CACS (OR = 2.37; 95% CI 1.18&ndash;4.78; p=0.017).</p><p><strong>Conclusion: </strong>Elevated UA levels and adverse cardiometabolic indices are associated with greater coronary artery calcification. The UA/eGFR ratio independently predicts higher CACS, highlighting its potential prognostic value.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geographic location and place of surgery on treatment outcomes of total hip replacement.","authors":"Slavko Manojlovic, Dragana Dragicevic-Cvjetkovic, Nemanja Manojlović, Zeljko Jovičić, Mirko Manojlović, Ferid Krupić","doi":"10.17392/2026-23-01","DOIUrl":"https://doi.org/10.17392/2026-23-01","url":null,"abstract":"<p><strong>Introduction: </strong>Environmental factors may influence postoperative outcomes and quality of life following total hip replacement (THR). This study investigated the impact of the geographical location of the surgical site, as well as the patient&rsquo;s place of birth and residence, on treatment outcomes in individuals with artificial hips.</p><p><strong>Methods: </strong>A prospective study was conducted involving 280 patients (both genderes; mean age 62 &plusmn; 8.8 years) who underwent THR due to primary or secondary hip osteoarthritis. Patients were divided into two groups: Group A (n = 64) included individuals who were not operated on in their place of birth and residence, while Group B (n = 216) consisted of those who were born, resided, and underwent surgery in the same geographical location. Outcomes were assessed using the EQ-5D questionnaire (covering mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), the Visual Analogue Scale (VAS) for pain, and a VAS-based treatment satisfaction scale, administered preoperatively and one year postoperatively. Statistical analysis was performed using Fisher&rsquo;s exact test (p &lt; 0.05).</p><p><strong>Results: </strong>Only 22.9% of all patients underwent surgery in their place of birth and residence, mostly for primary hip osteoarthritis. Preoperatively, Group A reported significantly greater limitations in self-care (p &lt; 0.05). One year postoperatively, Group B showed significantly higher VAS scores for treatment satisfaction (p &lt; 0.05).</p><p><strong>Conclusion: </strong>Patients who underwent total hip replacement in their place of birth and residence demonstrated better postoperative outcomes compared to those who had relocated.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory myofibroblastic tumor in pediatric patients: a Bosnian cohort.","authors":"Asmir Jonuzi, Ilhana Tinjak, Melika Bukvic, Benjamin Kulovac, Nusret Popovic, Emir Milisic, Zlatan Zvizdic","doi":"10.17392/2013-23-01","DOIUrl":"https://doi.org/10.17392/2013-23-01","url":null,"abstract":"<p><strong>Aim: </strong>Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of intermediate biological potential, characterized by spindle cell proliferation and significant inflammatory component. This study aimed to determine the clinicopathologic characteristics, the clinical outcomes of inflammatory myofibroblastic tumor cases in the low-volume pediatric surgery service in a developing country.</p><p><strong>Materials and methods: </strong>The study included data from all IMTcases diagnosed and operated from 2010 to 2024 &nbsp;at the Clinic of Pediatric Surgery, Clinical Center University of Sarajevo.</p><p><strong>Results: </strong>Three pediatric patients (two females, one male) diagnosed with IMT were analyzed for demographic, clinical, histopathological, immunohistochemical, and outcome parameters. All tumors were located in the abdominal or abdominopelvic region, with a median patient age of 4 years. Clinical manifestations included non-specific gastrointestinal symptoms (n=2) and systemic signs such as fever (n=2), weight loss and weakness (n=1). Complete surgical resection was conducted in all patients, and all experienced complete remission without recurrence. Histopathological analysis revealed consistent presence of spindle cells within a prominent inflammatory milieu, rich in plasma cells and lymphocytes. Immunohistochemically, all tumors were positive for vimentin, ALK, and SMA, while ALK-FISH analysis (performed in one case) was negative. No significant nuclear atypia or mitotic activity was observed.</p><p><strong>Conclusion: </strong>Our study showed the constant of its heterogeneous morphology, and significance of IMTs immunophenotype, particularly in older children, where the inflammatory component is more pronounced. ALK gene alterations are commonly associated with IMT, as well as with other types of pediatric neoplasms, however, favorable outcomes in our cohort study, raise question regarding further need to clarify the prognostic significance of molecular findings and their potential therapeutic implications.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"106-110"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory parameters, clinical characteristics and hemogram-derived indices in adult patients with measles at tertiary hospital admission.","authors":"Berina Hasanefendić, Amila Muratspahić, Semir Hrvo, Emina Hajrović Hebibović, Lejla Avdagić, Almedina Moro, Emir Šeherčehajić, Amir Sandžić","doi":"10.17392/2020-23-01","DOIUrl":"https://doi.org/10.17392/2020-23-01","url":null,"abstract":"<p><strong>Aim: </strong>To describe the clinical picture and laboratory findings, as well as to examine the significance of novel hemogram-derived inflammatory indices in adult patients with measles admitted to a tertiary hospital.</p><p><strong>Methods: </strong>This prospective, descriptive, and analytical study included adult patients over 18 years of age with clinical signs of measles, admitted at the Clinic for Infectious Diseases, Clinical Center of Sarajevo. Upon admission, medical history, physical examination, and laboratory analyses were conducted from February 2024 to 31 December 2024.</p><p><strong>Results: </strong>The study included 124 patients, 52 men and 72 were women with a mean age of 38.33&plusmn;13.18 years. The most common symptoms in most patients were rash (95.97%) and cough (69.36%). Neutrophilia (63.7%) and lymphopenia (74.19%) were the main hematological features along with elevated C-reactive protein (CRP) (95.17%) and transaminase (75%) in the vast majority of patients. The results of laboratory analyzes also indicated hyponatremia and hypokalemia, with elevated values ​​of the enzymes creatine kinase (CK) and lactate dehydrogenase (LDH). The CRP, as the most commonly elevated laboratory parameter, showed positive, significant correlation with Neutrophil/Lymphocyte ratio (NLR), Systemic Inflammation Response Index (SIRI) (p&lt;0.05) and Systemic immune-inflammation index (SII) and Aggregate Index of Systemic&nbsp;Inflammation (AISI) (p&lt;0.01).</p><p><strong>Conclusion: </strong>Adult measles was associated with significant inflammation, hematologic changes, and organ involvement, with CRP showing strong correlations with hemogram-derived indices. These findings suggesting that they may be useful in diagnostics of measles.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking analysis of thymoquinone as a potential inhibitor of C-reactive protein and transforming growth factor &beta; (TGF-&beta;): an in-silico study for myocardial infarction therapeutics.","authors":"Muhammad Saugi Abduh, Ahmad Umar Alfaruq, Muh Adytia Prasada, Dimas Nabih","doi":"10.17392/2011-23-01","DOIUrl":"https://doi.org/10.17392/2011-23-01","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction (MI) is a cardiovascular disease that is the leading cause of death at all ages. Inflammation and oxidation processes constitute the basic pathophysiology of MI development. C-reactive protein (CRP) and transforming growth factor &beta; (TGF-&beta;) are markers that are often used to evaluate the level of inflammation, especially in MI.</p><p><strong>Objective: </strong>This study aimed to evaluate the anti-inflammatory potential of thymoquinone (TQ), the major bioactive compound of Nigella sativa, by assessing its binding affinity through molecular docking, in which TQ exhibited more favorable binding energies compared to the native ligand.</p><p><strong>Methods: </strong>Using the VegaZZ, PyMOL, and BIOVIA Discovery Studio tools, AutoDock Vina software was used for in silico research to test the active molecule TQ and produce visual profiles of native CRP and TGF-&beta; ligands. Using the pkCSM method, pharmacokinetic predictions were carried out.</p><p><strong>Results: </strong>Thymoquinone (2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione) showed favorable binding affinity to both CRP and TGF-&beta;, with docking scores of &ndash;3.60 and &ndash;4.15 kcal/mol, respectively, which are more favorable than those of the native ligands (&ndash;2.39 and &ndash;2.73 kcal/mol) and comparable to enalapril (&ndash;4.84 and &ndash;6.13 kcal/mol). The RMSD value for CRP was 1.421 &Aring;, while the value for TGF-&beta; was 0.253 &Aring;, indicating excellent structural alignment and validating the docking approach.</p><p><strong>Conclusions: </strong>These in silico findings suggest that TQ warrants further investigation in vitro and in vivo as a potential modulator of inflammatory pathways in MI.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of tourniquet reperfusion interval on malondialdehyde (MDA) level and skeletal muscle damage in the treatment of long bone fractures.","authors":"Adhi Satriyo Utomo, Thomas Erwin Christian Junus Huwae","doi":"10.17392/2056-23-01","DOIUrl":"https://doi.org/10.17392/2056-23-01","url":null,"abstract":"<p><strong>Aim: </strong>Tourniquets are commonly used during surgery to control bleeding; however, their application can lead to complications, including ischemic reperfusion injury. Post-tourniquet syndromes such as pain, swelling, and muscle weakness may persist for up to six weeks. Aim of this study was to investigate the reperfusion interval duration to prevent muscle tissue damage.</p><p><strong>Methods: </strong>This experimental study involved 48 male white rats (Rattus norvegicus) with induced tibial fracture. The rats were divided into two groups, A and B, with each group receiving four different treatments, resulting in a total of eight groups. The control groups (A1 and B1) had the tourniquet applied for 3 hours, while other groups had it used for 2 hours, followed by 5, 10, and 15-minute reperfusion intervals. Group A was sacrificed one hour post-deflation, and Group B was sacrificed on day 14. Malondialdehyde (MDA) level and muscle histology were analysed using one-way ANOVA.</p><p><strong>Results: </strong>In group A, significant difference was found between the 10 and 15-minute reperfusion intervals. In group B, the 10-minute reperfusion interval showed the most favourable outcome, with a 42.63% reduction in injury for group A and a 32.27% reduction for group B. Significant differences in MDA level was found between the control and reperfusion groups in both groups A and B.</p><p><strong>Conclusion: </strong>The 10-minute reperfusion interval effectively reduces ischemic reperfusion injury in muscle tissue, as indicated by lower MDA level and less muscle damage. This interval optimally restores aerobic metabolism and prevents excessive reactive oxygen species (ROS) production.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of donor and procedural parameters on platelet yield in plateletpheresis: a retrospective data analysis over a seven-month period.","authors":"Gorana Ahmetovic-Karic, Kenan Mehic, Selim Arifovic, Ajsa Zildzic, Faruk Bradaric","doi":"10.17392/2053-23-01","DOIUrl":"https://doi.org/10.17392/2053-23-01","url":null,"abstract":"<p><strong>Aim: </strong>To identify the donor and procedural parameters that influence the platelet yield obtained by apheresis.</p><p><strong>Methods: </strong>A retrospective observation study of 60 plateletpheresis in the Blood Transfusion Institute of Federation of Bosnia and Herzegovina in Sarajevo, was done. Plateletpheresis were performed using Amicus cell separator with platelet collection protocol, and in accordance with the work procedure of the institution. The results were compared using statistical correlation and statistical comparison between groups. The demographic and hematologic parameters of donors, as well as procedural characteristics were correlated with their platelet yield. P&lt;0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean pre-donation platelet count was 252x10e9/L. Mean platelet yield was 3.5x10e11/unit. In the majority of donors, 48 (80%), amount of ˃3x10e11/unit was collected. Positive correlation was observed between platelet yield and pre-donation platelet count (r=0.611, p&lt;0.000), blood volume processed (r=0.512, p&lt;0.000), body weight (r=0.525, p&lt;0.000), body height (r=0.264, p=0.042), and run time (r=0.514, p&lt;0.000). Study also observed positive correlation between actual product platelet yield and the software predicted yield (rs=0.774, p&lt;0,000) with statistical difference between them (p&lt;0.000).</p><p><strong>Conclusions: </strong>Pre-donation platelet count, body weight, body height, blood volume processed and run time affected platelet yield. Optimizing the platelet yield is a matter of identifying the factors that influence the yield and thus the selection of donors, providing better quality platelet products and clinical outcomes.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D supplementation on metabolic syndrome and atherosclerosis biomarkers in epilepsy: a randomized controlled trial.","authors":"Sri Handayani, Zen Hafy, Fitri Octaviana, Zulkhair Ali, Nita Parisa, Astri Budikayanti, Dessy Agustini, Radiyati Umi Partan","doi":"10.17392/2062-23-01","DOIUrl":"https://doi.org/10.17392/2062-23-01","url":null,"abstract":"<p><strong>Aim: </strong>To analyze the effect of vitamin D administration on serum 25(OH)D levels and biomarkers of metabolic syndrome and atherosclerosis (homeostatic model assessment of insulin resistance [HOMA-IR], adiponectin, homocysteine, and high sensitivity C-reactive protein [hs-CRP]) in epilepsy patients receiving enzymatic antiseizure medications (ASMs).</p><p><strong>Methods: </strong>This double-blind, randomized, placebo-controlled trial randomized 40 adult epilepsy patients treated with enzymatic ASMs to receive vitamin D3 (2,000 IU/day) or placebo for 12 weeks. The primary outcome was the change in serum 25-hydroxyvitamin D (25[OH]D) levels. Secondary outcomes included changes in HOMA-IR, adiponectin, homocysteine, and hs-CRP. Data were analyzed using a per-protocol approach.</p><p><strong>Results: </strong>Thirty-four patients completed the study. Vitamin D supplementation yielded a significantly greater increase in serum 25(OH)D (10.67 &plusmn; 8.16 vs. &ndash;1.29 &plusmn; 3.96 ng/mL; p &lt; 0.001) and adiponectin (1.38 &plusmn; 3.05 vs. 0.34 &plusmn; 1.89 &micro;g/mL; p = 0.045), as well as a significantly greater reduction in hs-CRP (&ndash;6.74 &plusmn; 14.65 vs. 1.81 &plusmn; 7.75 mg/L; p = 0.041) compared with placebo. Conversely, no significant differences were observed between groups regarding the changes in HOMA-IR (&ndash;0.24 &plusmn; 3.71 vs. &ndash;0.14 &plusmn; 3.38; p = 0.940) or homocysteine (7.90 &plusmn; 1.79 vs. 8.15 &plusmn; 2.70 &micro;mol/L; p = 0.290).</p><p><strong>Conclusion: </strong>Vitamin D supplementation (2,000 IU/day) effectively restores 25(OH)D levels and improves adiponectin and hs-CRP in epilepsy patients on enzymatic ASMs, suggesting a potential benefit for cardiovascular risk reduction. However, vitamin D alone did not prevent the rise in homocysteine, likely due to the concurrent cessation of B-vitamin supplementation.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"111-116"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Trust and the Role of Misinformation in Childhood Immunization Decisions.","authors":"Anesa Terzić, Elma Mujaković, Emir Bećirović, Minela Bećirović, Almira Ćosićkić","doi":"10.17392/2004-23-01","DOIUrl":"https://doi.org/10.17392/2004-23-01","url":null,"abstract":"<p><strong>Aim: </strong>Vaccine hesitancy challenges global public health, with parental attitudes significantly impacting childhood immunization. This study examined parental perceptions of vaccine safety, effectiveness, and decision-making factors in Bosnia and Herzegovina.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted in March 2025 with 233 parents at a Primary Healthcare Center in Gračanica. A structured questionnaire based on the Parent Attitude about Childhood Vaccines (PACV) assessed sociodemographic data, vaccination experiences, information sources, and attitudes toward vaccines using a Likert scale.</p><p><strong>Results: </strong>Among 233 participants, 195 (83.7%) fully vaccinated their children, 30 (12.9%) practiced selective vaccination, and eight (3.4%) refused all vaccines. Vaccine hesitancy was significantly associated with lower education, (26.3% vs. 5.1%; p&lt;0.001), rural residence (76.3% vs. 48.2%; p=0.002), and having three or more children (34.2% vs. 12.3%; p=0.01). Trust in healthcare professionals strongly influenced behavior, with 178 (91.3%) of parents who fully trusted doctors adhering to the immunization schedule. Concerns about autism were reported by 14 (36.8%) of hesitant parents and were significantly associated with delayed or refused vaccination (p&lt;0.001).</p><p><strong>Conclusion: </strong>Although overall confidence was high, vaccine hesitancy persisted due to perceived risks. Strengthening healthcare communication and addressing misinformation, particularly autism concerns, may help improve vaccine uptake.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian Model Prediction for Lung Cancer Survival Based on Demographic and Laboratory Results: A retrospective analysis.","authors":"Islam Bani Mohammad, Muayyad Ahmad","doi":"10.17392/1970-23-01","DOIUrl":"https://doi.org/10.17392/1970-23-01","url":null,"abstract":"<p><strong>Aim: </strong>To examine the likelihood of predicting lung cancer survival versus death using Bayesian model based on demographic and laboratory data.</p><p><strong>Methods: </strong>A predictive design using electronic health records from 2012 to 2023 was implemented. IBM SPSS Statistics version 29.0 was used for data descriptive analysis and prediction models were built using SPSS Modeler version 18.0. Among the eight generated models, the Bayesian model demonstrated the highest accuracy (71.9%) and the best area under the curve (AUC) at 80.304, showcasing its superior predictive performance for lung cancer outcome.</p><p><strong>Results: </strong>A total of 1,843 patients without missing values were used. Males constituted 64.2 % of total sample. About 70 % of the patients were aged between 46 and 99 years. The Bayesian Network identified seven key predictors for determining patient outcome (survival versus death). Among these, age was found as the most significant predictor of survival outcome.</p><p><strong>Conclusion: </strong>The Bayesian Network outperformed other models in predicting lung cancer survival versus death probability. The integration of routine laboratory testing and demographic data in the machine learning model can help in the prediction of lung cancer survival versus death.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}