Medicinski Glasnik最新文献_第4页

Risk factors and microbiological profile of ventilator-associated pneumonia in a tertiary-care intensive care unit in Tuzla: a prospective observational study. 图兹拉三级重症监护病房中呼吸机相关肺炎的危险因素和微生物特征：一项前瞻性观察研究

Medicinski Glasnik Pub Date : 2026-07-08 DOI: 10.17392/medglas-2167-23-2

Minela Becirovic, Emir Becirovic, Jusuf Hodžić, Amir Becirovic, Elma Mujaković, Admir Abdić, Radojka Golijan

{"title":"Risk factors and microbiological profile of ventilator-associated pneumonia in a tertiary-care intensive care unit in Tuzla: a prospective observational study.","authors":"Minela Becirovic, Emir Becirovic, Jusuf Hodžić, Amir Becirovic, Elma Mujaković, Admir Abdić, Radojka Golijan","doi":"10.17392/medglas-2167-23-2","DOIUrl":"10.17392/medglas-2167-23-2","url":null,"abstract":"Aim: To determine the prevalence and microbiological profile of ventilator-associated pneumonia (VAP) in mechanically ventilated patients and to assess clinical and laboratory parameters associated with its development, with emphasis on C-reactive protein (CRP) levels and duration of mechanical ventilation.Methods: This single-centre prospective observational cohort study included 118 adult patients who required invasive mechanical ventilation for more than 48 hours in the intensive care unit of the University Clinical Centre Tuzla. Patients were classified into VAP and non-VAP groups. Demographic, clinical, laboratory, and microbiological data were collected, and in-hospital outcomes were recorded. Statistical analysis included between-group comparisons, univariate logistic regression, and receiver operating characteristic (ROC) curve analysis.Results: VAP was diagnosed in 41 patients (34.7%). Gram-negative pathogens predominated (≈ 85%), with Acinetobacter baumannii identified most frequently (43.9%), followed by Pseudomonas aeruginosa and Klebsiella pneumoniae. Patients with VAP had significantly longer durations of mechanical ventilation (12.5 vs. 7.3 days, p < 0.001) and hospitalisation (19.6 vs. 12.2 days, p < 0.001), as well as higher CRP levels (178.2 vs. 126.4 mg/L, p < 0.001). Reintubation, elevated CRP, leukocytosis, hypercapnia, and prolonged mechanical ventilation were associated with VAP. CRP demonstrated good-to-moderate discriminative ability for VAP (AUC = 0.83).Conclusion: VAP remains a common and clinically significant complication in mechanically ventilated patients. Elevated CRP levels and prolonged mechanical ventilation may support early clinical suspicion using routinely available parameters.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parents' perception of their own and their child's weight in relation to objectively measured body mass index. 父母认为自己和孩子的体重与客观测量的体重指数之间的关系。

Medicinski Glasnik Pub Date : 2026-07-08 DOI: 10.17392/medglas-2169-23-2

Mirela Lisičić-Konaković, Nurka Pranjić, Senka Mesihović-Dinarević, Melika Melunović, Adisa Čengić, Velma Selmanović, Selma Azabagić

{"title":"Parents' perception of their own and their child's weight in relation to objectively measured body mass index.","authors":"Mirela Lisičić-Konaković, Nurka Pranjić, Senka Mesihović-Dinarević, Melika Melunović, Adisa Čengić, Velma Selmanović, Selma Azabagić","doi":"10.17392/medglas-2169-23-2","DOIUrl":"10.17392/medglas-2169-23-2","url":null,"abstract":"Aim: To examine the association between parental and child body mass index (BMI), and parental perceptions of their own and their child's weight in relation to measured BMI.Methods: This cross-sectional study included 1,343 children aged 3-6 years and 1,343 parents from primary healthcare centres and preschool institutions in Sarajevo. Data on sociodemographic characteristics, parental weight perceptions, and anthropometric parameters were collected using a questionnaire. BMI was calculated according to the National Centre for Chronic Disease Prevention and Health Promotion recommendations.Results: The mean parental BMI was 25.1 ± 3.8. Overall, 460 (34.25%) parents were overweight and 140 (10.43%) were obese. Among children, 171 (12.7%) were underweight, 790 (58.8%) had normal weight, 159 (11.9%) were overweight, and 223 (16.6%) were obese. Higher parental BMI was associated with lower relative risk of underweight (RRR=0.94; 95%CI = 0.89-0.99; p = 0.021), slightly higher risk of overweight (RRR = 1.04; 95%CI = 1.00-1.09; p = 0.047), and higher risk of obesity (RRR = 1.09; 95% CI = 1.04-1.13; p < 0.001). Parental perception of child weight status differed significantly from measured BMI (p < 0.001), with very low sensitivity for child overweight and obesity of 10.5% (95%CI 7.8 - 13.9) and specificity of 99.2% (95% CI 98.4-99.6). Among parents, 100 overweight and 105 obese individuals perceived themselves as normal weight.Conclusion: Parental BMI was positively associated with child BMI. Misperception of parent and child weight was common, supporting improved awareness and targeted prevention.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between peptic ulcer disease and depression risk: The role of serotonin as a diagnostic biomarker in a case-control study. 消化性溃疡疾病与抑郁风险之间的关系：在病例对照研究中血清素作为诊断性生物标志物的作用

Medicinski Glasnik Pub Date : 2026-07-08 DOI: 10.17392/medglas-2168-23-2

Sajjad Fadhil K Abbas, Abeer Cheaid Yousif Al-Fatlawi

{"title":"The association between peptic ulcer disease and depression risk: The role of serotonin as a diagnostic biomarker in a case-control study.","authors":"Sajjad Fadhil K Abbas, Abeer Cheaid Yousif Al-Fatlawi","doi":"10.17392/medglas-2168-23-2","DOIUrl":"10.17392/medglas-2168-23-2","url":null,"abstract":"Aim: To evaluate serum serotonin levels in patients with peptic ulcer disease (PUD) and assess its potential as a biomarker associated with depressive symptoms in patients with PUD.Methods: This case-control study included 50 adult male patients with endoscopically confirmed PUD and 50 apparently healthy male controls. Serum serotonin levels were measured using enzyme-linked immunosorbent assay (ELISA). Depression was diagnosed by a psychologist and assessed using the Patient Health Questionnaire-9 (PHQ-9). Statistical analyses included the Mann-Whitney U test, chi-square test, multivariate logistic regression, and receiver operating characteristic (ROC) curve analysis.Results: Patients with PUD had higher PHQ-9 scores than controls, with a median score of 13.5 (7.0-16.6) versus 4.0 (2.0-8.0) (p<0.001). Serum serotonin levels were lower in patients with PUD than in controls, with a median of 530.086 (435.7-592.8) pg/mL versus 1008.763 (874.89-1120.43) pg/mL (p<0.001). In the adjusted model, lower serotonin levels remained independently associated with comorbid PUD-depression status (OR=0.992; 95% CI 0.988-0.996; p<0.001). ROC analysis showed high diagnostic performance for serotonin in the full sample (AUC=0.920; 95% CI 0.870-0.970; cut-off 803.131 pg/mL; sensitivity 85.0%; specificity 100%).Conclusion: Serum serotonin levels were lower in male patients with PUD and depressive symptoms than in healthy controls. Serotonin may have diagnostic value as a biomarker associated with depressive symptoms in patients with PUD, but longitudinal studies including women and PUD patients without depression are required.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between intradialytic blood pressure and left ventricular mass index in end-stage renal disease. 终末期肾病患者血溶内血压与左心室质量指数的关系

Medicinski Glasnik Pub Date : 2026-07-08 DOI: 10.17392/medglas-2170-23-2

Adnan Mušanović, Anis Cerovac, Senaid Trnačević, Demir Bedak

{"title":"Association between intradialytic blood pressure and left ventricular mass index in end-stage renal disease.","authors":"Adnan Mušanović, Anis Cerovac, Senaid Trnačević, Demir Bedak","doi":"10.17392/medglas-2170-23-2","DOIUrl":"10.17392/medglas-2170-23-2","url":null,"abstract":"Aim: To evaluate whether single and two-month average intradialytic blood pressure (BP) measurements, including systolic blood pressure (SBP) and diastolic blood pressure (DBP), are associated with left ventricular mass index (LVMI), and whether intradialytic BP thresholds discriminate left ventricular hypertrophy (LVH) in patients with end-stage renal disease on haemodialysis.Methods: This prospective observational study was conducted at the Dialysis Centre in Doboj between June and September 2017 and included 97 adults on chronic haemodialysis for at least five months. Intradialytic BP was assessed as a single measurement and as a two-month average. LVMI and LVH were evaluated by echocardiography. Multivariable regression examined associations with LVMI after adjustment for age, haemoglobin, and volume overload, while receiver operating characteristic (ROC) curve analysis assessed LVH discrimination.Results: Median dialysis duration was 3.9 years, and 24 patients (25%) had ischemic heart disease. Median LVMI was 117.5 g/m2, and LVH was present in 44 patients (45%). After adjustment for relevant covariates, single intradialytic SBP and DBP measurements were not associated with LVMI. In contrast, two-month average SBP (B = 0.5364, p = 0.0075) and DBP (B = 0.7308, p = 0.0299) remained independently associated with LVMI. Two-month average SBP showed moderate LVH discrimination (area under the curve (AUC) 0.711; p = 0.0001), with an exploratory cut-off of >143 mmHg.Conclusion: Two-month average intradialytic SBP was independently associated with higher LVMI and showed moderate discrimination for LVH but requires external validation.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early left ventricular ejection fraction trajectories according to CTox risk score in breast cancer patients treated with anthracycline and/or trastuzumab. 蒽环类药物和/或曲妥珠单抗治疗乳腺癌患者CTox风险评分的早期左室射血分数轨迹

Medicinski Glasnik Pub Date : 2026-06-18 DOI: 10.17392/medglas-2166-23-2

Cynthia Margaretha, Naomi Dalimunthe, Heny Syahrini Lubis, Taufik Sungkar, Melati Silvanni Nasution

{"title":"Early left ventricular ejection fraction trajectories according to CTox risk score in breast cancer patients treated with anthracycline and/or trastuzumab.","authors":"Cynthia Margaretha, Naomi Dalimunthe, Heny Syahrini Lubis, Taufik Sungkar, Melati Silvanni Nasution","doi":"10.17392/medglas-2166-23-2","DOIUrl":"10.17392/medglas-2166-23-2","url":null,"abstract":"Aim: To evaluate early within-patient changes in left ventricular ejection fraction (LVEF) and to describe these early LVEF trajectories according to CTox risk category.Methods: This retrospective observational cohort study included 100 breast cancer patients treated at Adam Malik Hospital, from January to December 2024. CTox score was calculated prior to therapy initiation. Echocardiography was performed before the third cycle and after the fourth cycle of anthracycline- or trastuzumab-based therapy. The primary endpoint was early within-patient change in LVEF.Results: Based on CTox classification, 53% of patients were categorized as low-to-moderate risk and 47% as high-to-very high risk. Mean LVEF decreased from 62.64 ± 7.80% to 59.95 ± 7.46%, with a mean change of -2.69 ± 9.01% (p = 0.004). Early LVEF change did not differ between risk groups (between-group difference 0.54%; 95% CI, -2.97 to 4.05; p = 0.766). CTox score was not associated with early LVEF change when modelled as a continuous variable (β = 0.55; p = 0.453) or after adjustment for treatment regimen (β = 0.92; p = 0.212). Treatment type was independently associated with early LVEF change (p = 0.026).Conclusion: A modest early decline in LVEF was observed during initial therapy cycles. Early LVEF trajectory was not associated with CTox risk category but was influenced by treatment regimen. These findings should be interpreted as early imaging trajectory data rather than cardiotoxicity risk prediction.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative anxiety in major abdominal surgery: analysis of contributing factors using the Hamilton Anxiety Rating Scale (HAM-A). 腹部大手术围手术期焦虑：汉密尔顿焦虑评定量表（HAM-A）影响因素分析

Medicinski Glasnik Pub Date : 2026-06-18 DOI: 10.17392/medglas-2164-23-2

Mirza Kovačević, Anida Abazovic Bihorac, Jasmina Smajic, Anel Okić, Ferid Krupic

{"title":"Perioperative anxiety in major abdominal surgery: analysis of contributing factors using the Hamilton Anxiety Rating Scale (HAM-A).","authors":"Mirza Kovačević, Anida Abazovic Bihorac, Jasmina Smajic, Anel Okić, Ferid Krupic","doi":"10.17392/medglas-2164-23-2","DOIUrl":"10.17392/medglas-2164-23-2","url":null,"abstract":"Aim: To evaluate factors associated with perioperative anxiety in patients undergoing major abdominal surgery under general anaesthesia (GA) using the Hamilton Anxiety Rating Scale (HAM-A).Methods: This prospective observational study included 107 adult patients scheduled for major abdominal surgery under GA. Anxiety was assessed preoperatively and postoperatively using the HAM-A. Demographic characteristics, medical history, lifestyle habits, and perioperative variables were analysed. Multivariable analysis was conducted to identify factors independently associated with pre- and postoperative anxiety.Results: Preoperative anxiety was observed in 54 patients (50.5%), while postoperative anxiety occurred in 34 patients (31.8%). Multivariable analysis identified alcohol consumption (β = 8.10, 95%CI: 0.46-14.07; p = 0.037), hyperlipoproteinemia (β = 1.81, 95%CI: 1.42-2.19; p < 0.001), preoperative fasting duration (β = 0.03, 95%CI: 0.02-0.04; p = 0.005), surgery duration (β = -0.45, 95%CI: -0.74- -0.13; p = 0.006), and anaesthesia duration (β = 0.43, 95%CI: 0.07-0.70; p = 0.015) as factors independently associated with preoperative anxiety. The type of intravenous anaesthetic showed a trend toward significance (β = -5.45, 95%CI: -10.20-0.08; p = 0.054). Factors independently associated with postoperative anxiety included age (β ='0.08, 95%CI: 0.01-0.17; p = 0.018), previous hospitalisations (β = 6.43, 95%CI: 3.69-11.86; p < 0.001), previous surgeries (β = 8.13, 95%CI: 6.25-14.44; p < 0.001), and preoperative fasting duration (β = 2.87, 95%CI: 1.90-4.79; p < 0.001).Conclusion: Routine assessment using the HAM-A scale may help identify high-risk patients and guide targeted perioperative strategies, including preoperative counselling and optimization of fasting protocols.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Admission patterns, early mortality, and organisational workload in a medical intensive care unit: An eight-year retrospective study at a tertiary care centre. 医疗重症监护病房的入院模式、早期死亡率和组织工作量：三级护理中心的8年回顾性研究

Medicinski Glasnik Pub Date : 2026-06-18 DOI: 10.17392/medglas-2165-23-2

Emir Becirovic, Minela Becirovic, Davor Tokic, Amir Becirovic, Alma Serak Tokic

{"title":"Admission patterns, early mortality, and organisational workload in a medical intensive care unit: An eight-year retrospective study at a tertiary care centre.","authors":"Emir Becirovic, Minela Becirovic, Davor Tokic, Amir Becirovic, Alma Serak Tokic","doi":"10.17392/medglas-2165-23-2","DOIUrl":"10.17392/medglas-2165-23-2","url":null,"abstract":"Aim: To analyse patient admission patterns, clinical outcomes, and organisational workload in a medical intensive care unit (ICU), with emphasis on early mortality and post-pandemic changes in healthcare demand.Methods: This retrospective, observational, single-centre cohort study included all adult patients admitted to the medical ICU of the Clinic for Internal Medicine at the University Clinical Centre Tuzla between January 1, 2018, and December 31, 2025. Aggregated data were obtained from the hospital information system and internal ICU records. Analysed variables included annual admission volume, admission sources, discharge outcomes, in-hospital and early mortality (within 24-72 hours after ICU admission), estimated length of stay, invasive procedures, and patient age. Temporal trends were assessed across pre-pandemic (2018-2019), pandemic (2020-2021), and post-pandemic (2022-2025) periods.Results: A total of 9,342 ICU hospitalisations were analysed. Admissions remained relatively stable through 2020, declined in 2021, reached their lowest level in 2022, and then increased markedly from 2023 onward. Admissions per bed rose from 67.5 in 2022 to 108.6 in 2025, while the estimated mean ICU length of stay decreased from 5.4 to 3.4 days. Overall, in-hospital mortality was approximately 22%, with 75-80% of deaths occurring between 24 and 72 hours from admission. The patient population was predominantly elderly, with a mean age of approximately 70 years.Conclusion: Medical ICU services operated under increasing organisational strain, reflected by rising admission volume, higher admissions per bed, and reduced estimated length of stay despite fixed bed capacity. Persistently high early mortality remained a prominent feature of this population.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Lactobacillus rhamnosus probiotic supplementation on gut health in rabbits. 鼠李糖乳杆菌益生菌对家兔肠道健康的影响。

Medicinski Glasnik Pub Date : 2026-02-27 DOI: 10.17392/2035-23-01

Taghreed Al-Fakje, Faeha Al-Mashhadane, ِAsmaa Al-Nuaimy

{"title":"Effects of Lactobacillus rhamnosus probiotic supplementation on gut health in rabbits.","authors":"Taghreed Al-Fakje, Faeha Al-Mashhadane, ِAsmaa Al-Nuaimy","doi":"10.17392/2035-23-01","DOIUrl":"10.17392/2035-23-01","url":null,"abstract":"Aim: The research examined the effects of prolonged oral Lactobacillus rhamnosus intake on rabbit intestinal tissue morphology.Methods: The study included twelve male rabbits aged 10–12 months and weighing 1.5–2.0 kg who received random assignment to two groups of six animals each. The control group received distilled water but the experimental group received L. rhamnosus orally at 0.25 mL/kg/day for 45 days. The research team performed histological and morphometric analysis on duodenal samples to measure villus height and width and crypt depth and villus area and VH/CD ratio and muscularis thickness through ImageJ software.Results: The extended probiotic treatment caused villus disorganization and epithelial necrosis and villus fusion and inflammatory infiltration and submucosal edema. The quantitative analysis showed that all measured parameters including villus height and VH/CD ratio and villus area and muscularis thickness demonstrated significant decreases (p<0.05) when compared to the control group. The results show that absorptive capacity was impaired.Conclusion: The duodenal mucosa developed structural and functional changes because of extended exposure to high L. rhamnosus concentrations which indicates that long-term probiotic use could be harmful. Research needs to determine the correct dosage amounts and duration of treatment for non-rodent species.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"76-79"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes and complications of exposed Kirschner wire fixation for metacarpal fractures: a retrospective study. 外露克氏针固定治疗掌骨骨折的疗效和并发症：一项回顾性研究。

Medicinski Glasnik Pub Date : 2026-02-27 DOI: 10.17392/2015-23-01

Andrea Cruciani, Silvia Pietramala, Alessio Greco, Alessandro El Motassime, Camillo Fulchignoni, Lorenzo Rocchi

{"title":"Outcomes and complications of exposed Kirschner wire fixation for metacarpal fractures: a retrospective study.","authors":"Andrea Cruciani, Silvia Pietramala, Alessio Greco, Alessandro El Motassime, Camillo Fulchignoni, Lorenzo Rocchi","doi":"10.17392/2015-23-01","DOIUrl":"10.17392/2015-23-01","url":null,"abstract":"Aim: Metacarpal fractures are common hand injuries, frequently treated with closed reduction and internal fixation (CRIF) using Kirschner wires (K-wires). While exposed K-wires allow for simple hardware removal and early mobilization, their use is traditionally associated with a higher risk of pin tract infections. There is a lack of studies focusing exclusively on exposed K-wires in metacarpal fractures.Methods: It was retrospectively reviewed 134 patients who underwent CRIF with exposed K-wires for metacarpal fractures between January 2023 and March 2024. After applying inclusion and exclusion criteria, 118 patients were analyzed. Demographics, fracture characteristics, complications, and follow-up data were collected. Functional outcomes were assessed using the QuickDASH and the Michigan Hand Outcomes Questionnaire (MHQ) before hardware removal.Results: Most patients were male, 88 (75%), with a mean age of 39.3 years. The little finger was the most frequently injured, 71 (60%). In 102 (86%) cases, a single metacarpal fracture was observed. The average number of wires used was 1.7, and hardware was removed after a mean of 40.1 days. The rate of pin tract infection was <4%, all classified as superficial and managed conservatively. Only one case required reoperation due to secondary displacement. The mean QuickDASH score was 25, and the average MHQ score was 70.15, indicating overall good functional and patient-reported outcomes.Conclusion: Exposed K-wire fixation for metacarpal fractures appears safe and reliable, with low complication rates and favorable patient-reported outcomes, supporting its use in outpatient pathways without compromising safety.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated neutrophil-to-lymphocyte ratio predicts poorer histopathological differentiation in colorectal cancer: a study from a Southeast Asian Tertiary Hospital. 中性粒细胞与淋巴细胞比值升高预示结直肠癌较差的组织病理分化：一项来自东南亚三级医院的研究

Medicinski Glasnik Pub Date : 2026-02-27 DOI: 10.17392/2012-23-01

Edwin Saleh Siregar, Muhammad Al Anas, Dedy Hermansyah

{"title":"Elevated neutrophil-to-lymphocyte ratio predicts poorer histopathological differentiation in colorectal cancer: a study from a Southeast Asian Tertiary Hospital.","authors":"Edwin Saleh Siregar, Muhammad Al Anas, Dedy Hermansyah","doi":"10.17392/2012-23-01","DOIUrl":"10.17392/2012-23-01","url":null,"abstract":"Aim: of this study was to evaluate the correlation between pre-treatment NLR and histopathological differentiation in colorectal cancer, and to assess the diagnostic accuracy of NLR as a predictive biomarker.Methods: A retrospective study was conducted at Adam Malik Haji Center General Hospital Medan, North Sumatera. Medical records of 45 colorectal cancer patients treated between January and December 2024 were reviewed. Pre-treatment NLR values were calculated from peripheral blood counts. Receiver Operating Characteristic (ROC) curve analysis was performed to determine diagnostic performance, and correlation analysis was used to assess the relationship between NLR and tumour grade.Results: The mean NLR was 6.33±4.92. ROC analysis yielded an area under the curve (AUC) of 0.874, indicating excellent diagnostic ability. An NLR cutoff value of 6.25 provided a sensitivity of 87.5% and specificity of 72.5% for predicting poor histopathological differentiation. A moderate positive correlation (r=0.612; p<0.001) was found between higher NLR values and poorer differentiation.Conclusion: Pre-treatment NLR correlated with histopathological grade and showed promise as a simple, non-invasive biomarker for assessing tumour aggressiveness in colorectal cancer.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"23 1","pages":"80-84"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0