Maturitas最新文献

{"title":"A review on essential oils: A potential tonic for mental wellbeing in the aging population?","authors":"Vivek Chavda ,&nbsp;Pankti Balar ,&nbsp;Vasso Apostolopoulos","doi":"10.1016/j.maturitas.2024.108158","DOIUrl":"10.1016/j.maturitas.2024.108158","url":null,"abstract":"<div><div>Mental wellbeing is crucial to a good quality of life. With progression in life, mental health can deteriorate, leading to multiple disorders, such as depression, anxiety, stress, and insomnia. Essential oils, from various sources, have a long history of use in aromatherapy. Herein, we review the current literature related to the psychological effects of essential oils, emphasizing their impact on mood regulation, stress reduction, sleep disturbances, and cognitive function. Various mechanisms, such as alterations to the neurotransmitter system, endocrine changes, and anti-oxidant activity are reviewed. The non-invasive nature of essential oils suggests they have a promising role as adjuncts to conventional therapies for improving the mental health of the aging population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"192 ","pages":"Article 108158"},"PeriodicalIF":3.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabinoids and the male reproductive system: Implications of endocannabinoid signaling pathways","authors":"Biswajeet Acharya ,&nbsp;Prafulla Kumar Sahu ,&nbsp;Amulyaratna Behera ,&nbsp;Jack Feehan ,&nbsp;Durga Prasad Mishra ,&nbsp;Vasso Apostolopoulos","doi":"10.1016/j.maturitas.2024.108156","DOIUrl":"10.1016/j.maturitas.2024.108156","url":null,"abstract":"<div><div>The escalating use and legalization of cannabis (marijuana) in the United States reflect shifting societal attitudes and growing awareness of its potential therapeutic benefits. Historically viewed as a harmful psychoactive substance, contemporary research has shown the intricate pharmacology of cannabis, with its diverse array of cannabinoids and their interactions with the endocannabinoid system. Among these cannabinoids, Δ9-tetrahydrocannabinol is the primary psychoactive component, characterized by its activation of cannabinoid receptors. The discovery of endocannabinoids, including anandamide and 2-arachidonoylglycerol, illuminated the body's innate cannabinoid signaling pathways and their involvement in several physiological processes. Endocannabinoids exert both positive and negative effects on the male reproductive system. They facilitate erectile function by modulating neurotransmission and vasodilation, offering potential therapeutic avenues for conditions like erectile dysfunction and prostatitis. However, chronic exogenous cannabinoid use, mainly of tetrahydrocannabinol, poses risks to male reproductive health by disrupting spermatogenesis, causing hormonal imbalances, and potentially influencing cancer cell proliferation. Understanding endocannabinoid signaling in the male reproductive system is essential to fully comprehend both the therapeutic benefits and potential drawbacks of cannabis use. Further research is required on these mechanisms, to provide insights that can guide clinical practice and policy-making regarding cannabis use. In this narrative review, we highlight the need for additional research into how cannabinoids affect male reproductive health, particularly with prolonged use. Investigating cannabinoids' impacts on spermatogenesis, hormonal balance, and cancer cell proliferation can provide valuable insights for healthcare professionals.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"192 ","pages":"Article 108156"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and histomorphometric evaluation of the vagina following treatment with CO2 laser, radiofrequency, and promestriene for genitourinary syndrome of menopause in breast cancer survivors on adjuvant therapy","authors":"Gabriela C. Cantarelli ,&nbsp;Ana M.H.M. Bianchi-Ferraro ,&nbsp;Chayanne Dedonatto ,&nbsp;Marcela F.R. Fernandes ,&nbsp;Rafaela B. Vanzin ,&nbsp;Rita C.M. Dardes ,&nbsp;Angela F. Logullo ,&nbsp;Joaquim S. de Almeida ,&nbsp;Gil Facina ,&nbsp;Zsuzsanna I.K. de Jármy-Di Bella ,&nbsp;Marair G.F. Sartori ,&nbsp;Marisa T. Patriarca ,&nbsp;LARF-Study Group","doi":"10.1016/j.maturitas.2024.108155","DOIUrl":"10.1016/j.maturitas.2024.108155","url":null,"abstract":"<div><h3>Purpose</h3><div>To perform clinical and histomorphometric evaluations of the vagina before and after treatment for genitourinary syndrome of menopause with CO₂ laser, fractional radiofrequency, and promestriene in breast cancer survivors using adjuvant endocrine therapy.</div></div><div><h3>Methods</h3><div>The study included women experiencing moderate to severe genitourinary syndrome of menopause. Following pre- and post-treatment protocols, participants graded their symptoms on a visual analog scale and underwent a gynecological examination to evaluate the Vaginal Health Index and obtain a vaginal biopsy. Subsequently, they were randomized to laser, radiofrequency, and promestriene groups. The energy groups underwent three consecutive monthly outpatient vulvovaginal treatments, while the control group received promestriene treatment for four months, followed by a post-treatment evaluation.</div></div><div><h3>Results</h3><div>Sixty-two women completed the study protocol (21 laser, 20 radiofrequency, and 21 promestriene). While histological differences (vaginal thickness [<em>p</em> = 0.002] and number of stromal papillae [<em>p</em> = 0.004]) were observed between the pretreatment samples of tamoxifen and anastrozole users, the symptoms did not differ between them. A decrease in symptom intensity (<em>p</em> &lt; 0.05) and an improvement in the Vaginal Health Index (<em>p</em> &lt; 0.001) were observed post-treatment, regardless of the type of adjuvant endocrine therapy used. Most pretreatment vaginal samples did not indicate histological atrophy, and no significant histological differences were observed after treatment. No clinical or histological damage was observed.</div></div><div><h3>Conclusion</h3><div>CO₂ laser and radiofrequency therapies could be considered alternative treatments for genitourinary syndrome of menopause in breast cancer survivors receiving adjuvant therapy. These treatments promoted significant improvements comparable to those delivered by promestriene, without histological or clinical tissue damage.</div><div>Trial Registration Number: <span><span>NCT04081805</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108155"},"PeriodicalIF":3.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between menopause, body composition, and nonalcoholic fatty liver disease: A prospective cohort in northern China","authors":"Chenlu Yang ,&nbsp;Shuohua Chen ,&nbsp;Baoyu Feng ,&nbsp;Ying Lu ,&nbsp;Yanhong Wang ,&nbsp;Wei Liao ,&nbsp;Shouling Wu ,&nbsp;Li Wang","doi":"10.1016/j.maturitas.2024.108148","DOIUrl":"10.1016/j.maturitas.2024.108148","url":null,"abstract":"<div><h3>Background</h3><div>The association between menopause, changes in body composition, and nonalcoholic fatty liver disease is not clear, and there is a lack of weight management strategies for perimenopausal women from the perspective of preventing nonalcoholic fatty liver disease.</div></div><div><h3>Methods</h3><div>A total of 1316 postmenopausal and 3049 premenopausal women in the Kailuan cohort in China between 2006 and 2017 were enrolled and followed up till 2021. Cox regression models, including the causal mediation analyses, were used to estimate the association between menopause and nonalcoholic fatty liver disease and the potential mediation effect of changes in body composition. We also explored the impact of weight changes on the correlation between menopause and nonalcoholic fatty liver disease.</div></div><div><h3>Results</h3><div>Women who experienced menopause had a higher risk of nonalcoholic fatty liver disease than premenopausal women (9-year cumulative incidence: 56.87 % vs. 48.80 %, adjusted hazard ratio = 1.219, 95 % confidence interval: 1.088–1.365). The nine-year cumulative incidence of nonalcoholic fatty liver disease was higher among overweight/obese postmenopausal women (67.24 % vs. 45.74 %, <em>P</em> &lt; 0.001) and those with abdominal obesity (63.36 % vs. 49.69 %, <em>P</em> &lt; 0.001); however, the hazard ratio of menopause for nonalcoholic fatty liver disease was more evident in women with a body mass index under 23.0 kg/m² (hazard ratio = 1.434, 95 % confidence interval: 1.168–1.759) and those with normal waist circumference (hazard ratio = 1.362, 95 % confidence interval: 1.129–1.643), which could partially be explained by the visceral fat index (7.09 % and 7.35 % mediation, respectively). Weight loss of 3 % or more or reduction in waist circumference by 5 % or more was associated with a 31.1 % reduction (95 % confidence interval, 20.8 %–40.0 %) or a 14.2 % reduction (95 % confidence interval, 1.1 %–25.6 %) in the risk of nonalcoholic fatty liver disease among the premenopausal women. For postmenopausal women, weight gain of 3 % or more was associated with an increased risk of nonalcoholic fatty liver disease, especially in individuals with a body mass index under 23.0 kg/m².</div></div><div><h3>Conclusion</h3><div>Menopause was associated with a higher risk of nonalcoholic fatty liver disease, partially by increasing visceral fat. Controlling weight in perimenopausal women may reduce the risk.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"192 ","pages":"Article 108148"},"PeriodicalIF":3.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of childhood socioeconomic position and health with trajectories of grip strength from middle to older ages in populations from China and England","authors":"Mphatso Chisala ,&nbsp;Rebecca Hardy ,&nbsp;Rachel Cooper ,&nbsp;Leah Li","doi":"10.1016/j.maturitas.2024.108154","DOIUrl":"10.1016/j.maturitas.2024.108154","url":null,"abstract":"<div><h3>Background</h3><div>We investigated associations of childhood socioeconomic position and health with trajectories of grip strength from middle to older ages in two distinct populations.</div></div><div><h3>Methods</h3><div>We used data from the China Health and Retirement Longitudinal Study (CHARLS, <em>n</em> = 16,701) and English Longitudinal Study of Ageing (ELSA, <em>n</em> = 12,695). Hand grip strength was measured at three timepoints in CHARLS (2011–2015) and four in ELSA (2001−2020). Random-effects growth models were applied to assess associations between each childhood factor and age trajectories of grip strength.</div></div><div><h3>Findings</h3><div>Lower parental education was associated with weaker grip strength, by 0·36 kg(95 % CI:0·17,0·56) for participants of illiterate (vs literate) parents in CHARLS and 1·88 kg(0·43,3·33) for participants of parents without education (vs ≥ high school) in ELSA, after adjusting for parental occupation and own adult socioeconomic position. Low parental occupation was associated with weaker grip strength, although the difference diminished after adjustment for adult socioeconomic position. Financial hardship was associated with weaker grip strength only in CHARLS, by 0·19 kg(0·01,0·38) after adjustment. Self-rated poor childhood health and school absenteeism were associated with weaker grip strength (both studies). Being confined to bed and hospitalised for more than a month due to health were associated with weaker grip strength only in CHARLS. Each additional childhood illness (only reported in ELSA) was associated with 0·52 kg(0·28,0·81) lower mean grip strength. Reported poor childhood health (CHARLS), low parental education and school absenteeism (ELSA) were associated with grip strength decline.</div></div><div><h3>Interpretation</h3><div>Lower socioeconomic position and poor health in childhood were associated with weaker grip strength in later life in both Chinese and English populations. Addressing socioeconomic disparities and promoting health of children may enhance life-course physical capacity, promote healthy ageing and reduce age-related adversities.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108154"},"PeriodicalIF":3.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of connective tissue massage on physical and emotional symptoms, insomnia, and quality of life in postmenopausal women: A randomized, sham-controlled trial","authors":"Gülnur Albayrak ,&nbsp;Ayla Çağlıyan Türk ,&nbsp;Serap Özgül","doi":"10.1016/j.maturitas.2024.108149","DOIUrl":"10.1016/j.maturitas.2024.108149","url":null,"abstract":"<div><h3>Objectives</h3><div>Connective tissue massage is a therapeutic approach with local, reflex, and systemic effects. This study evaluated the effects of connective tissue massage on postmenopausal symptoms, menopause-specific quality of life, and insomnia.</div></div><div><h3>Study design</h3><div>A total of 57 postmenopausal women were randomly allocated to either the massage group (<em>n</em> = 28) or the control group (sham therapeutic ultrasound) (<em>n</em> = 29). Participants received massage or the sham intervention in 3 sessions per week for 4 weeks, each session lasting 15 min. The Wilcoxon test was used for within-group comparisons, and the independent groups <em>t-</em>test, Mann-Whitney <em>U</em> test, or Pearson chi-square test were used for between-group comparisons. Statistical significance was set as <em>p</em> ≤ .05.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was menopausal symptom severity, assessed by the Menopause Rating Scale. Secondary outcomes included hot flash frequency, hot flash score (frequency × severity), menopause-specific quality of life, emotional status, insomnia, and satisfaction with the intervention.</div></div><div><h3>Results</h3><div>Data from 52 of the 57 participants were included in the final analysis. There was a greater improvement in the massage group compared with the control group in all primary and secondary outcome measures except insomnia severity (<em>p</em> ≤ .05).</div></div><div><h3>Conclusions</h3><div>Connective tissue massage can be offered as a first-line approach to improve physical and emotional health in the short term for postmenopausal women. Further studies are needed to determine the long-term effects.</div><div>Clinical trial registration number: <span><span>NCT05293860</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108149"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total choline intake, liver fibrosis and the progression of metabolic dysfunction-associated steatotic liver disease: Results from 2017 to 2020 NHANES","authors":"Siraphat Taesuwan ,&nbsp;Matina Kouvari ,&nbsp;Andrew J. McKune ,&nbsp;Demosthenes B. Panagiotakos ,&nbsp;Julaluk Khemacheewakul ,&nbsp;Noppol Leksawasdi ,&nbsp;Pornchai Rachtanapun ,&nbsp;Nenad Naumovski","doi":"10.1016/j.maturitas.2024.108150","DOIUrl":"10.1016/j.maturitas.2024.108150","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the cross-sectional relationships of total choline intake with the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to liver fibrosis.</div></div><div><h3>Study design</h3><div>The study used data on total choline intake, hepatic steatosis, and liver fibrosis from the cross-sectional 2017–2020 National Health and Nutrition Examination Survey, including 24-h dietary recalls and liver ultrasound elastography (FibroScan®).</div></div><div><h3>Main outcome measures</h3><div>Steatosis was defined as a controlled attenuation parameter score ≥ 285<!--> <!-->dB/m. Fibrosis was defined as median liver stiffness ≥8 kPa. Complex survey-adjusted regression models were used in all analyses. Effect modification by sex, race, and cardiometabolic risk factors was investigated.</div></div><div><h3>Result</h3><div>Total choline intake was not associated with MASLD status (<em>n</em> = 5687; odds ratio per 100 mg/d [95 % confidence interval]: 0.96 [0.85,1.09]; <em>P</em> = 0.55). However, among people with MASLD, a higher total choline intake was associated with higher odds of fibrosis (<em>n</em> = 2019; 1.15 [1.01,1.30]; <em>P</em> = 0.03). This association was observed in men (<em>P</em>-interaction = 0.1; 1.23 [1.02,1.48]; <em>P</em> = 0.03), but not in women (1.05 [0.88,1.24]; <em>P</em> = 1.0). Choline intake also tended to be positively associated with fibrosis in people with MASLD who were overweight or had central obesity (<em>P</em>-interaction = 0.02; 1.15 [1.00,1.34]; <em>P</em> = 0.06).</div></div><div><h3>Conclusions</h3><div>Overall, no significant association was observed between total choline intake and the prevalence of MASLD. However, in people with MASLD, a higher choline intake was associated with higher odds of developing liver fibrosis. This association appeared to differ by sex and cardiometabolic risk factors.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108150"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic associations of miRNA variants (miR-10a, miR-30c, miR-181a, miR-499b) with primary ovarian insufficiency in Korean women","authors":"Hui Jeong An ,&nbsp;Sung Hwan Cho ,&nbsp;Chang Soo Ryu ,&nbsp;Eun Ju Ko ,&nbsp;Hyeon Woo Park ,&nbsp;Young Ran Kim ,&nbsp;Eun Hee Ahn ,&nbsp;Ji Eun Shin ,&nbsp;Seong-Soo Joo ,&nbsp;Ji Hyang Kim ,&nbsp;Nam Keun Kim","doi":"10.1016/j.maturitas.2024.108153","DOIUrl":"10.1016/j.maturitas.2024.108153","url":null,"abstract":"<div><h3>Objectives</h3><div>MicroRNAs (miRNAs) are pivotal in post-transcriptionally modulating gene expression in both animals and plants. This study investigates the relationship between microRNA polymorphisms and the occurrence of primary ovarian insufficiency in Korean women. Our hypothesis posits that polymorphisms in microRNAs—specifically miR-10aA &gt; T, miR-30cA &gt; G, miR-181aT &gt; C, and miR-499bA &gt; G—may be linked to primary ovarian insufficiency, influencing the risk of developing the condition.</div></div><div><h3>Methods</h3><div>We conducted a case-control study of 141 Korean women with primary ovarian insufficiency and 281 control individuals with at least one live birth and no history of pregnancy loss.</div></div><div><h3>Results</h3><div>Our findings indicate that various combinations of these four microRNA polymorphic sites are associated with an increased risk of primary ovarian insufficiency. The combination analysis indicated a significant decrease in the frequency of the miR-181a/miR-499b TC/AA allele combination in individuals with primary ovarian insufficiency (<em>P</em> &lt; 0.05). Additionally, one-way analysis of variance of data from patients with primary ovarian insufficiency revealed that, in comparison with miR-181aTT, the miR-181aCC genotype was associated with significantly lower levels of both follicle-stimulating hormone and luteinizing hormone, suggesting potential protective effects.</div></div><div><h3>Conclusions</h3><div>Our data suggest that dysregulation of the miR-10aA &gt; T, miR-30cA &gt; G, miR-181aT &gt; C, and miR-499bA &gt; G polymorphisms in these microRNAs contributes to the regulation of target genes related to primary ovarian insufficiency.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108153"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the partner's obstructive sleep apnea on metabolic syndrome in couples","authors":"Kayoung Lee","doi":"10.1016/j.maturitas.2024.108147","DOIUrl":"10.1016/j.maturitas.2024.108147","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the relationship between the risk of obstructive sleep apnea, as assessed by the STOP-Bang questionnaire, and metabolic syndrome among couples. It also examines how snoring and observed apnea are associated with metabolic syndrome in couples.</div></div><div><h3>Study design</h3><div>Cross-sectional study using data from 2436 couples in the Korea National Health and Nutrition Examination Survey (2019–2021). A high risk of obstructive sleep apnea was defined as a STOP-Bang score of 3 or more (excluding the hypertension item).</div></div><div><h3>Main outcome measures</h3><div>Metabolic syndrome in couples.</div></div><div><h3>Results</h3><div>47.6 % of husbands and 5.7 % of wives had a high risk of obstructive sleep apnea. The prevalence of metabolic syndrome was 45.5 % among husbands and 24.7 % among wives. After adjusting for sociodemographic factors and health behaviors, wives whose husbands were at high risk of obstructive sleep apnea or who reported snoring or observed apnea had 1.4–1.5 times higher odds of metabolic syndrome. Conversely, husbands' metabolic syndrome was not significantly associated with their wives' risk of obstructive sleep apnea and sleep behaviors. The adjusted odds of metabolic syndrome in both partners were 2.8–4.4 times higher when only husbands had a high risk of obstructive sleep apnea or snoring, and 2.3–2.9 times higher when only wives had these sleep issues, compared with couples without such problems.</div></div><div><h3>Conclusions</h3><div>This study reveals a gender disparity in the impact of a spouse's risk of obstructive sleep apnea on metabolic syndrome, emphasizing the need for a couple-focused approach in managing these health issues.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108147"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a home-based exercise program on subsequent falls among community-dwelling older adults with cognitive frailty: A sub-group analysis of a randomized controlled trial","authors":"Ryan S. Falck ,&nbsp;Chun Liang Hsu ,&nbsp;Jennifer C. Davis ,&nbsp;Jordyn Rice ,&nbsp;Elizabeth Dao ,&nbsp;Larry Dian ,&nbsp;Kenneth Madden ,&nbsp;Dawn A. Skelton ,&nbsp;Naaz Parmar ,&nbsp;Wendy L. Cook ,&nbsp;Karim M. Khan ,&nbsp;Teresa Liu-Ambrose","doi":"10.1016/j.maturitas.2024.108151","DOIUrl":"10.1016/j.maturitas.2024.108151","url":null,"abstract":"<div><h3>Objectives</h3><div>Cognitive frailty is characterized by concurrent physical frailty and mild cognitive impairment and is associated with increased risk of falls. Exercise is an evidence-based strategy to prevent falls, but whether exercise reduces falls in people with cognitive frailty is unknown. We examined the effects of home-based exercise on subsequent falls among community-dwelling older adults with cognitive frailty who have previously fallen.</div></div><div><h3>Study design</h3><div>A sub-group analysis of a 12-month, single-blind, randomized controlled trial among 344 adults aged 70 years or more who had fallen within the past 12 months. Participants were randomized to either 12 months of home-based exercise (<em>n</em>=172) or usual care (n=172). In this sub-analysis, we included 192 participants with cognitive frailty (home-based exercise=93; usual care=99) with Short Physical Performance Battery scores ≤9/12 and Montreal Cognitive Assessment scores &lt;26/30.</div></div><div><h3>Main outcome measures</h3><div>Our primary analysis examined the effect of exercise on self-reported falls rate over 12 months. Secondary analyses investigated the intervention's effects on scores on the Short Physical Performance Battery and the Montreal Cognitive Assessment. We also explored whether greater than or equal to mean average monthly adherence (i.e., ≥45.5%) moderated treatment effects.</div></div><div><h3>Results</h3><div>At 12 months, falls rates were 35% lower in the home-based exercise group compared with the usual care group (IRR=0.65; <em>p</em><em>=</em>0.042). Score on the Short Physical Performance Battery significantly improved among home-based exercise participants with greater than or equal to mean adherence vs. those with less than mean adherence (estimated mean difference: 0.94; <em>p</em>=0.022).</div></div><div><h3>Conclusions</h3><div>Exercise is a promising strategy for reducing subsequent falls in people with cognitive frailty. Greater exercise adherence improved physical function in this population.</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> identifier: <span><span>NCT01029171</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108151"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}