Maturitas最新文献

{"title":"Trends in the incidence of vulvar malignant melanoma in Denmark and Sweden: Two nationwide studies covering >40 years","authors":"Kirstine Duffau ,&nbsp;Guoqiao Zheng ,&nbsp;Christian Munk ,&nbsp;Karin Sundström ,&nbsp;Jiangrong Wang ,&nbsp;Louise Baandrup ,&nbsp;Merete Hædersdal ,&nbsp;Susanne K. Kjær","doi":"10.1016/j.maturitas.2025.108633","DOIUrl":"10.1016/j.maturitas.2025.108633","url":null,"abstract":"<div><h3>Objectives</h3><div>Vulvar malignant melanoma (VuMM) represents a rare malignancy. This study examines and compares the incidence and trends in incidence of VuMM in Denmark and in Sweden over a period of &gt;40 years.</div></div><div><h3>Study design</h3><div>A nationwide, population-based registry study conducted in two countries.</div></div><div><h3>Main outcome measures</h3><div>We identified incident VuMM cases in the Danish and Swedish Cancer Registries. Information on age at diagnosis, anatomical site, histology, and stage of disease was retrieved. We calculated age-specific and age-standardized incidence rates (ASRs) with temporal trends in incidence evaluated by estimated annual percent change (EAPC) with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>A total of 524 women with VuMM, encompassing 171 women in Denmark (1978–2022) and 353 women in Sweden (1978–2018), were included. The age-specific incidence rates increased with age throughout the study period in both countries. The ASR decreased in both countries: in Denmark, from 1.03 (95 % CI: 0.59–1.48) per 1,000,000 to 0.55 (95 % CI: 0.26–0.83); and in Sweden from 1.25 (95 % CI: 0.22–2.28) to 0.76 (95 % CI: 0.42–0.84). This corresponded to EAPCs of −1.65 (95 % CI: −2.45; −0.84) in Denmark and −1.22 (95 % CI: −1.69; −0.75) in Sweden.</div></div><div><h3>Conclusions</h3><div>The age-standardized and age-specific VuMM incidence rates were nearly identical in Denmark and Sweden, which are countries with similar demographic characteristics, and a free-of-charge healthcare system. The incidence of VuMM showed an equal and statistically significant decrease in Denmark and Sweden during the last four decades. The explanation for the decrease is currently unknown.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108633"},"PeriodicalIF":3.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating biomarkers for the preoperative diagnosis of uterine sarcoma: A systematic review and meta-analysis","authors":"Cristina Taliento ,&nbsp;Christine De Bruyn ,&nbsp;Jolien Ceusters ,&nbsp;Dirk Timmerman ,&nbsp;Thierry Van den Bosch ,&nbsp;An Coosemans","doi":"10.1016/j.maturitas.2025.108634","DOIUrl":"10.1016/j.maturitas.2025.108634","url":null,"abstract":"<div><h3>Objective</h3><div>A way to improve the early diagnosis of uterine sarcoma is by identifying circulating protein biomarkers that allow for differentiation between uterine sarcoma and benign leiomyomas. However, to date, no systematic review has gathered data on the diagnostic accuracy of these biomarkers as diagnostic tools for uterine sarcomas.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis. An electronic search was conducted using PubMed, EMBASE, Web of Science, and CENTRAL (Cochrane) to identify clinical studies investigating the potential role of circulating biomarkers for the diagnosis of uterine sarcoma. We selected only studies that compared patients with a histologically confirmed diagnosis of leiomyoma versus uterine sarcoma. This study was conducted according to the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies statement.</div></div><div><h3>Results</h3><div>A total of 20 observational studies were included, with a total of 13 biomarkers. Five studies reported data on diagnostic accuracy, including sensitivity and specificity. Lactate dehydrogenase levels showed a statistically significant difference between patients with uterine sarcoma and controls with leiomyoma (p &lt; 0.001), with a sensitivity and specificity ranging between 0.47 and 1.00 and 0.86 to 1.00, respectively. Three studies reported data on diagnostic accuracy of carbohydrate antigen 125: the estimates for sensitivity and specificity ranged from 0.43 to 0.64 and 0.50 to 0.77, respectively, with substantial heterogeneity between the studies. Data on diagnostic accuracy for C-reactive protein was available for two studies, with sensitivity and specificity ranging between 0.84 and 0.87 and 0.83 to 0.89, respectively. Data for two biomarkers, human epididymal protein 4 and D-dimer, were insufficient, as each was evaluated in only one study.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis showed that the most encouraging results were available for lactate dehydrogenase. Other biomarkers may also prove to be useful tools in differentiating between leiomyomas and uterine sarcomas; however, further studies are needed to replicate these findings.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108634"},"PeriodicalIF":3.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive impact of a menopause website – MyMenoplan.org – on treatment intentions, knowledge, and decision making: A randomized controlled trial","authors":"Leslie B. Snyder ,&nbsp;Katherine M. Newton ,&nbsp;Hui Xin Ng ,&nbsp;Susan D. Reed ,&nbsp;Katherine A. Guthrie ,&nbsp;Viviana Zambrano ,&nbsp;Andrea Z. LaCroix","doi":"10.1016/j.maturitas.2025.108630","DOIUrl":"10.1016/j.maturitas.2025.108630","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the impact of a new website, <span><span>MyMenoplan.org</span><svg><path></path></svg></span>, on menopause knowledge, decision-making progress, treatment and coping intentions among people experiencing perimenopause and menopause. The website was designed to provide women and their clinicians with comprehensive, evidence-based information and decision-making tools about a broad range of symptoms and treatments, address common questions and facilitate conversations with clinicians when desired.</div></div><div><h3>Study design</h3><div>Women were recruited online and randomized to interact with the <span><span>MyMenoplan.org</span><svg><path></path></svg></span> website created by MsFLASH investigators (<em>n</em> = 200) or control websites (<em>n</em> = 210) for at least 20 min before completing an online survey. Women in the control arm could choose any website(s), including three suggested high-quality websites from governmental or non-profit organizations. Fraud-detection protocols were followed. Outcome differences by arm were estimated via adjusted linear regression models.</div></div><div><h3>Primary outcomes</h3><div>Behavioral change intentions, menopause knowledge, decision-making progress, and user website experience.</div></div><div><h3>Results</h3><div>99 % of controls visited at least one recommended website. Compared with the control arm, the <span><span>MyMenoplan.org</span><svg><path></path></svg></span> arm reported significantly higher levels of intent to change treatment (3.87 vs. 3.61), knowledge of menopause symptoms and treatments (4.17 vs. 3.85), treatment decision-making progress (3.94 vs. 3.71), clarity about benefits and risks of treatments (4.04 vs. 3.81), perceived website quality (4.05 vs. 3.70), intentions to return to the website (4.40 vs. 3.97), and likelihood of recommending it to others (4.35 vs. 4.04; each <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div><span><span>MyMenoplan.org</span><svg><path></path></svg></span> is the first NIH-funded website shown to be effective in helping women learn and make decisions about management of the menopause transition. The website serves as a model for providing much-needed, evidence-based information for health-care providers and women nearing or in perimenopause and menopause.</div><div>Clinical Trial Registration Number: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> ID <span><span>NCT05299983</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108630"},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theimpact of obesity on perioperative care: Integrating ERAS protocols for improved surgical outcomes","authors":"Maria Fanaki,&nbsp;Dimitrios Haidopoulos,&nbsp;Dimitrios Efthimios Vlachos,&nbsp;Vasileios Lygizos,&nbsp;Antonia Varthaliti,&nbsp;Nikolaos Thomakos,&nbsp;Vasileios Pergialiotis","doi":"10.1016/j.maturitas.2025.108598","DOIUrl":"10.1016/j.maturitas.2025.108598","url":null,"abstract":"<div><div>Obesity represents a global health crisis, affecting over 650 million adults worldwide and markedly influencing surgical outcomes, particularly in the context of gynecologic oncology. It serves as a considerable risk factor for perioperative complications, impacting metabolic, respiratory, immune, and cardiovascular functions. Patients with obesity undergoing surgical procedures in gynecologic oncology exhibit higher incidences of wound infections, thromboembolic events, respiratory failure, and extended hospital stays. The Enhanced Recovery After Surgery (ERAS) protocol has emerged as a robust perioperative strategy to mitigate these risks and enhance surgical outcomes.</div><div>Obesity leads to significant alterations in body composition, including increased adipose tissue, causing chronic inflammation and insulin resistance, which elevate the risk of wound infections and delayed healing. Respiratory complications are exacerbated by reduced lung compliance and obstructive sleep apnea, while cardiovascular strain and thromboembolism risks are heightened by systemic inflammation and coagulation imbalances. Immune dysregulation further impairs recovery by compromising wound healing and increasing susceptibility to infection. ERAS protocols counteract these challenges through multimodal strategies, including prehabilitation, carbohydrate loading, immunonutrition, glycemic control, respiratory optimization, and enhanced mobilization. Implementing ERAS protocols has been shown to reduce postoperative morbidity by 32 %, to decrease the duration of hospital stay, to reduce the readmission rate by 20 % and to enhance overall recovery.</div><div>Integrating ERAS protocols into perioperative care for obese patients is essential for minimizing complications and enhancing recovery. A multidisciplinary, individualized approach that includes metabolic optimization, respiratory management, and thromboprophylaxis is crucial in this high-risk population. Future research should focus on refining ERAS protocols for obesity, exploring personalized nutrition strategies, and investigating long-term surgical outcomes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108598"},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probability of progression and regression of chronic kidney disease in patients with type 2 diabetes mellitus","authors":"Barry Moses Quan Ren Koh ,&nbsp;Feng He ,&nbsp;Gavin Siew Wei Tan ,&nbsp;Cynthia Ciwei Lim ,&nbsp;Kavita Venkataraman ,&nbsp;Charumathi Sabanayagam","doi":"10.1016/j.maturitas.2025.108599","DOIUrl":"10.1016/j.maturitas.2025.108599","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the annual transitions between the stages of diabetic kidney disease (DKD) in an Asian population with type 2 diabetes.</div></div><div><h3>Study design</h3><div>Longitudinal cohort study.</div></div><div><h3>Main outcome measures</h3><div>We analysed 15,913 clinic visits by 5980 patients (Chinese, Malay and Indian) who attended at least 2 annual primary care visits from 2010 to 2015, with DKD categorised into G1-G5 stages by estimated glomerular filtration rate. We applied a multistate Markov model adjusting for risk factors to estimate annual transition probabilities and sojourn times.</div></div><div><h3>Results</h3><div>Median (interquartile range) follow-up duration was 2.01 (1.11–2.93) years. Annual transition probabilities of progression from G1-G2 to G3 and G3 to G4-G5 were 1.26 % and 1.21 % respectively. Annual death rates among the G1-G2, G3 and G4-G5 groups were 0.92 %, 1.63 %, and 5.84 %, respectively. Estimated sojourn times in the G1-G2, G3 and G4-G5 groups were 43.73, 6.97, and 6.32 years, respectively. Among modifiable risk factors, progression from G1-G2 to G3 was associated with higher systolic blood pressure while death was associated with the presence of diabetic retinopathy, higher hemoglobin A1_c (HbA1c) and lower body mass index.</div></div><div><h3>Conclusions</h3><div>Annual DKD progression in this screened population was slow but death from advanced stages was high. Ongoing surveillance and targeted control of risk factors such as blood pressure, HbA1c, and diabetic retinopathy may help improve outcomes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108599"},"PeriodicalIF":3.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of biomarkers of cellular senescence with physical and cognitive function among older women with or without a history of premenopausal bilateral oophorectomy","authors":"Zaira Aversa ,&nbsp;Ryan D. Frank ,&nbsp;Jennifer R. Geske ,&nbsp;Thomas A. White ,&nbsp;Amanda A. Heeren ,&nbsp;Ekta Kapoor ,&nbsp;Walter A. Rocca ,&nbsp;Marissa J. Schafer ,&nbsp;Julie A. Fields ,&nbsp;Kejal Kantarci ,&nbsp;Michelle M. Mielke ,&nbsp;Nathan K. LeBrasseur","doi":"10.1016/j.maturitas.2025.108606","DOIUrl":"10.1016/j.maturitas.2025.108606","url":null,"abstract":"<div><h3>Objectives</h3><div>To study whether a history of premenopausal bilateral oophorectomy (PBO) may influence circulating concentrations of cellular senescence biomarkers and their associations with measures of physical and cognitive function later in life.</div></div><div><h3>Study design</h3><div>The plasma concentrations of 29 candidate senescence biomarkers and parameters of physical and cognitive function were measured in 510 older women, comprising 273 with a history of PBO and 237 referents.</div></div><div><h3>Main outcome measures</h3><div>Plasma concentrations of senescence biomarkers and their associations with measures of physical and cognitive function.</div></div><div><h3>Results</h3><div>In participants with a history of PBO compared to referents, only the plasma levels of tumor necrosis factor alpha (TNFα) and tumor necrosis factor receptor 2 (TNFR2) were statistically significantly higher than they were in the referent group, whereas matrix metalloproteinase 2 (MMP2) was lower. Overall, measures of physical and cognitive function did not differ between those with and without PBO. In an exploratory analysis, several senescence-related biomarkers were associated with chronological age, body mass index, and measures of physical function, including 6-minute walk distance and muscle strength and power. Only few biomarkers were associated with measures of cognitive function. Using machine learning, subsets of biomarkers in combination with demographic and clinical covariates exhibited higher value than the covariates alone in predicting most of the physical and cognitive function outcomes in cross-sectional analyses.</div></div><div><h3>Conclusions</h3><div>The circulating concentrations of several candidate senescence biomarkers were associated with physical and cognitive function in a cohort of older women, but only a few biomarkers differed between participants with a history of PBO and referents. Additional research is needed to better understand the influence of PBO on the biology of aging.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108606"},"PeriodicalIF":3.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia predicts mortality in older adults with cardiovascular disease: concordant findings from SDOC and EWGSOP II criteria despite limited role of low lean mass","authors":"Alberto Frisoli Junior ,&nbsp;Amanda Rocha Diniz ,&nbsp;Gustavo Duque ,&nbsp;Giovanna Menin ,&nbsp;Monica Maria Cartocci ,&nbsp;Izo Helber ,&nbsp;Antonio Carlos de Camargo Carvalho","doi":"10.1016/j.maturitas.2025.108618","DOIUrl":"10.1016/j.maturitas.2025.108618","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is a recognized risk factor for mortality in older adults, but inconsistencies in diagnostic criteria and classification methods have led to variability in assessing this risk. The role of low lean mass alone in predicting mortality remains unclear.</div></div><div><h3>Objective</h3><div>This study evaluates the predictive value of sarcopenia diagnoses using different methods and assesses the impact of low lean mass on mortality in outpatient older adults.</div></div><div><h3>Subjects and methods</h3><div>A longitudinal cohort analysis of 439 subjects was conducted, using diagnostic criteria from the Sarcopenia Definition and Outcomes Consortium (SDOC), which do not include low lean mass, and those from the European Working Group on Sarcopenia in Older People (EWGSOP II), which do. Mortality was assessed over an 18-month follow-up.</div></div><div><h3>Results</h3><div>The mean age was 78 years (<strong>±</strong>7.33). Sarcopenia was present in 46.5 % of patients based on the SDOC criteria, while EWGSOP II phenotypes identified probable sarcopenia in 26.2 %, confirmed sarcopenia in 3.2 %, and severe sarcopenia in 13 %. The mortality rate was 7.3 %, with 78.1 % of deceased patients meeting SDOC sarcopenia criteria and 71.8 % classified under EWGSOP II phenotypes. Adjusted hazard ratios for mortality showed significant associations for SDOC sarcopenia (HR = 5.444; 1.943–14.060; <em>p</em> = 0.001), probable sarcopenia (HR = 5.461; 1.848–16.131, <em>p</em> = 0.002), confirmed sarcopenia (HR = 2.789; 0.318–24.412; <em>p</em> = 0.354) and severe sarcopenia (HR = 5.170; 0.318–24.412, <em>p</em> = 0.028).</div></div><div><h3>Conclusion</h3><div>In older adults with cardiovascular disease, sarcopenia is a strong predictor of mortality, regardless of the diagnostic criteria used. However, low lean mass, whether considered in isolation or as part of sarcopenia, does not contribute to mortality risk.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108618"},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders and sexual function in women","authors":"Monica Levy Andersen,&nbsp;Sergio Tufik","doi":"10.1016/j.maturitas.2025.108625","DOIUrl":"10.1016/j.maturitas.2025.108625","url":null,"abstract":"<div><div>Sleep disorders are prevalent among women and can have significant implications for overall health, including sexual function. Emerging evidence suggests that disruptions to sleep, whether due to insomnia, obstructive sleep apnea, or circadian rhythm disorders, may adversely affect sexual desire, arousal, and satisfaction. This review provides a comprehensive overview of the literature, and examines the relationship between sleep disorders and sexual function in women. It explores the pathophysiological mechanisms, psychosocial factors, and hormonal influences that may mediate this relationship. The role of comorbid conditions, such as depression and anxiety, is discussed in light of their potential to exacerbate both sleep and sexual dysfunction. Although our understanding of these relationships is advancing, further research is necessary to uncover causal pathways and to inform the design of optimized treatment strategies. Contemporary research underscores the urgent need for a multidisciplinary approach to addressing the interplay between sleep disturbances and sexual dysfunction. Longitudinal studies involving diverse populations will be essential for tailoring effective treatments.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108625"},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related increase and sex difference in the prevalence of handgrip strength asymmetry among Chinese middle-aged and older adults","authors":"Yu Luo,&nbsp;Xiaoyi Ma,&nbsp;Kemin Yan,&nbsp;Ling Zhang,&nbsp;Wen He","doi":"10.1016/j.maturitas.2025.108622","DOIUrl":"10.1016/j.maturitas.2025.108622","url":null,"abstract":"<div><h3>Introduction</h3><div>In addition to weakness, asymmetry is increasingly recognized as an abnormal condition of handgrip strength (HGS), one which is associated with various adverse health outcomes in older adults. However, the influence of age and sex on the prevalence of HGS asymmetry remains unclear.</div></div><div><h3>Methods</h3><div>The study population included adults aged 45 to 85 years from two waves of the China Health and Retirement Longitudinal Study (CHARLS), categorized by 5-year age groups. HGS ratio was calculated by dividing the maximal HGS (stronger HGS) by the highest HGS value obtained from the opposite hand (weaker HGS). HGS asymmetry was defined as an HGS ratio &gt; 1.1, 1.2 or 1.3. Univariate and multivariate analyses were used to explore the associations of age and sex with HGS asymmetry.</div></div><div><h3>Results</h3><div>The prevalence of HGS asymmetry among Chinese middle-aged and older people, defined by an HGS ratio &gt; 1.1, 1.2, and 1.3, was 42.7 %, 15.6 %, and 6.4 %, respectively. Regardless of the diagnostic threshold, the prevalence of HGS asymmetry increased with age (all, p value for trend &lt;0.0001), starting primarily from 60 to 64 years. The risk of HGS asymmetry was significantly higher in women than in men, though this sex difference diminished after age 70. The age-related increase and sex difference in the risk of HGS asymmetry remained significant even after adjusting for multiple covariates.</div></div><div><h3>Conclusion</h3><div>The prevalence of HGS asymmetry increases with age and is higher in women. HGS asymmetry may serve as an additional marker of muscle function decline and should be routinely evaluated in assessing sarcopenia and frailty, particularly among women and the oldest-old.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108622"},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-based pelvic floor telerehabilitation for urinary incontinence in older women: A six-month follow-up pilot study","authors":"Mélanie Le Berre ,&nbsp;Johanne Filiatrault ,&nbsp;Barbara Reichetzer ,&nbsp;Dahlia Kairy ,&nbsp;Caroline Lachance ,&nbsp;Chantale Dumoulin","doi":"10.1016/j.maturitas.2025.108621","DOIUrl":"10.1016/j.maturitas.2025.108621","url":null,"abstract":"<div><h3>Background</h3><div>Urinary incontinence is prevalent among older women. This pilot study evaluated the effects of an online group-based pelvic floor muscle training program in older women with urinary incontinence at a six-month follow-up.</div></div><div><h3>Methods</h3><div>Women aged 65 and over, with stress or mixed urinary incontinence, were recruited. Eligibility was established through in-person evaluations, during which pelvic floor physiotherapists taught and verified correct pelvic floor muscles contraction using digital palpation. The 12-week online pelvic floor muscle training program comprised weekly one-hour training sessions, followed by an unsupervised maintenance exercise regimen. Data were collected before the program (PRE), immediately after (POST), during an interim phone call three months after the end of the program (3MO) and at a follow-up six months after the end of the program (6MO). Participants reported symptoms of urinary incontinence using a 7-day bladder diary and standardized questionnaires at PRE, POST and 6MO. Adherence to maintenance exercises was recorded at 3MO and 6MO. At 6MO, participants provided feedback on their perceived improvement and overall satisfaction.</div></div><div><h3>Results</h3><div>Women experienced a median leakage reduction of 73 % (range 38–88 %) from PRE to 6MO. Improvements were maintained from POST to 6MO for leakage episodes, symptoms of urinary incontinence, quality of life, and urinary incontinence self-efficacy. Adherence to maintenance exercises was substantial at 3MO and 6MO. Participants expressed high satisfaction with symptom improvement and the program overall at 6MO.</div></div><div><h3>Conclusions</h3><div>A 12-week online group-based pelvic floor muscle training including an in-person pelvic floor muscle evaluation and an unsupervised maintenance exercise regimen demonstrated sustained clinical benefits. Further validation through a randomized controlled trial is needed to confirm these findings.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108621"},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}