Associations of biomarkers of cellular senescence with physical and cognitive function among older women with or without a history of premenopausal bilateral oophorectomy

IF 3.6 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2025-06-02 DOI:10.1016/j.maturitas.2025.108606

Zaira Aversa , Ryan D. Frank , Jennifer R. Geske , Thomas A. White , Amanda A. Heeren , Ekta Kapoor , Walter A. Rocca , Marissa J. Schafer , Julie A. Fields , Kejal Kantarci , Michelle M. Mielke , Nathan K. LeBrasseur

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引用次数: 0

Abstract

Objectives

To study whether a history of premenopausal bilateral oophorectomy (PBO) may influence circulating concentrations of cellular senescence biomarkers and their associations with measures of physical and cognitive function later in life.

Study design

The plasma concentrations of 29 candidate senescence biomarkers and parameters of physical and cognitive function were measured in 510 older women, comprising 273 with a history of PBO and 237 referents.

Main outcome measures

Plasma concentrations of senescence biomarkers and their associations with measures of physical and cognitive function.

Results

In participants with a history of PBO compared to referents, only the plasma levels of tumor necrosis factor alpha (TNFα) and tumor necrosis factor receptor 2 (TNFR2) were statistically significantly higher than they were in the referent group, whereas matrix metalloproteinase 2 (MMP2) was lower. Overall, measures of physical and cognitive function did not differ between those with and without PBO. In an exploratory analysis, several senescence-related biomarkers were associated with chronological age, body mass index, and measures of physical function, including 6-minute walk distance and muscle strength and power. Only few biomarkers were associated with measures of cognitive function. Using machine learning, subsets of biomarkers in combination with demographic and clinical covariates exhibited higher value than the covariates alone in predicting most of the physical and cognitive function outcomes in cross-sectional analyses.

Conclusions

The circulating concentrations of several candidate senescence biomarkers were associated with physical and cognitive function in a cohort of older women, but only a few biomarkers differed between participants with a history of PBO and referents. Additional research is needed to better understand the influence of PBO on the biology of aging.

查看原文本刊更多论文

在有或没有绝经前双侧卵巢切除术史的老年妇女中，细胞衰老的生物标志物与身体和认知功能的关系

目的研究绝经前双侧卵巢切除术（PBO）的历史是否会影响细胞衰老生物标志物的循环浓度及其与以后生活中身体和认知功能的关系。研究设计测定了510名老年妇女29种候选衰老生物标志物的血浆浓度以及身体和认知功能参数，其中273名有PBO病史，237名参照物。主要结果测量衰老生物标志物的血浆浓度及其与身体和认知功能测量的关系。结果PBO患者血浆中肿瘤坏死因子α (TNFα)和肿瘤坏死因子受体2 （TNFR2）水平显著高于对照组，基质金属蛋白酶2 （MMP2）水平显著低于对照组。总的来说，身体和认知功能的测量在有和没有PBO的人之间没有差异。在一项探索性分析中，几种与衰老相关的生物标志物与实足年龄、体重指数和身体功能测量（包括6分钟步行距离和肌肉力量和力量）相关。只有少数生物标志物与认知功能测量相关。在横断面分析中，使用机器学习，生物标志物子集与人口统计学和临床协变量相结合，在预测大多数身体和认知功能结果方面表现出比单独协变量更高的价值。结论：几种候选衰老生物标志物的循环浓度与老年妇女的身体和认知功能有关，但只有少数生物标志物在有PBO病史的参与者和参考物之间存在差异。为了更好地了解PBO对衰老生物学的影响，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life