Maturitas最新文献

{"title":"Authors' reply to Yu-Hsiang Lin et al.","authors":"Rebecca Zurbuchen , Anna von Däniken , Heidrun Janka , Michael von Wolff , Petra Stute","doi":"10.1016/j.maturitas.2025.108253","DOIUrl":"10.1016/j.maturitas.2025.108253","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108253"},"PeriodicalIF":3.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of chair stand performance with all-cause and cardiovascular mortality in older adults with hypertension: A 28-country study","authors":"Ana Polo-López ,&nbsp;Rubén López-Bueno ,&nbsp;Joaquín Calatayud ,&nbsp;Rodrigo Núñez-Cortés ,&nbsp;Luis Suso-Martí ,&nbsp;Lars Louis Andersen","doi":"10.1016/j.maturitas.2025.108248","DOIUrl":"10.1016/j.maturitas.2025.108248","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the prospective association of chair stand performance with all-cause and cardiovascular mortality in older adults with hypertension.</div></div><div><h3>Methods</h3><div>From the Survey of Health, Ageing and Retirement in Europe (SHARE) study, we included 18,252 adults aged 50 years or more with hypertension from 28 countries (27 European countries and Israel). Chair stand performance was assessed by the time taken to complete five chair stands. We used time-varying Cox regression with restricted cubic splines to determine the prospective association of chair stand time with all-cause and cardiovascular mortality, controlling for various confounders.</div></div><div><h3>Key results</h3><div>Over a mean follow-up of 3.5 years, 648 participants died, with 243 deaths attributed to cardiovascular disease. Using the median chair stand time (11 s) as a reference, both faster and slower times were associated with altered mortality risk in a curvilinear fashion. For all-cause mortality, the 10th percentile of chair stand time (7 s) showed a hazard ratio (HR) of 0.71 (95 % CI 0.60–0.85), while the 90th percentile (19 s) showed a HR of 1.20 (95 % CI 1.10–1.32). For cardiovascular mortality, the 10th percentile showed a subdistribution hazard ratio (SHR) of 0.72 (95 % CI 0.53–0.97), while the 90th percentile showed a SHR of 1.28 (95 % CI 1.10–1.48).</div></div><div><h3>Conclusion</h3><div>Chair stand performance is gradually and inversely associated with risk of all-cause and cardiovascular mortality in older adults with hypertension. These findings highlight the potential of the chair stand test as a prognostic measure.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108248"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial function as a potential biomarker for biological aging","authors":"Yu-Hsiang Lin ,&nbsp;Kuo-Jen Lin ,&nbsp;Tsung-Hsing Chen","doi":"10.1016/j.maturitas.2025.108247","DOIUrl":"10.1016/j.maturitas.2025.108247","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108247"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of healthy ageing: Wearables in public health, disease prevention and healthcare","authors":"Marilyne Menassa ,&nbsp;Ilona Wilmont ,&nbsp;Sara Beigrezaei ,&nbsp;Arno Knobbe ,&nbsp;Vicente Artola Arita ,&nbsp;Jose F. Valderrama V ,&nbsp;Lara Bridge ,&nbsp;W.M. Monique Verschuren ,&nbsp;Kirsten L. Rennie ,&nbsp;Oscar H. Franco ,&nbsp;Frans van der Ouderaa","doi":"10.1016/j.maturitas.2025.108254","DOIUrl":"10.1016/j.maturitas.2025.108254","url":null,"abstract":"<div><div>Wearables have evolved into accessible tools for sports, research, and interventions. Their use has expanded to real-time monitoring of behavioural parameters related to ageing and health. This paper provides an overview of the literature on wearables in disease prevention and healthcare over the life course (not only in the older population), based on insights from the Future of Diagnostics Workshop (Leiden, January 2024).</div><div>Wearable-generated parameters include blood glucose, heart rate, step count, energy expenditure, and oxygen saturation. Integrating wearables in healthcare is protracted and far from mainstream implementation, but promises better diagnosis, biomonitoring, and assessment of medical interventions.</div><div>The main lifestyle factors monitored directly with wearables or through smartphone applications for disease prevention include physical activity, energy expenditure, gait, sleep, and sedentary behaviour. Insights on dietary consumption and nutrition have resulted from continuous glucose monitors. These factors are important for healthy ageing due to their effect on underlying disease pathways.</div><div>Inclusivity and engagement, data quality and ease of interpretation, privacy and ethics, user autonomy in decision making, and efficacy present challenges to but also opportunities for their use, especially by older people. These need to be addressed before wearables can be integrated into mainstream medical and public health strategies. Furthermore, six key considerations need to be tackled: 1) engagement, health literacy, and compliance with personalised feedback, 2) technical and standardisation requirements for scalability, 3) accountability, data safety/security, and ethical concerns, 4) technological considerations, access, and capacity building, 5) clinical relevance and risk of overdiagnosis/overmedicalisation, and 6) the clinician's perspective in implementation.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108254"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in body size associated with all-cause mortality in an older Chinese population","authors":"Dechen Liu,&nbsp;Jinjin Wang,&nbsp;Yuqi Niu,&nbsp;Guoli Yan","doi":"10.1016/j.maturitas.2025.108252","DOIUrl":"10.1016/j.maturitas.2025.108252","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence of an association between a change in body size and the risk of all-cause mortality is limited among older populations. We explored the association of a change in body size over three years with the risk of all-cause mortality in an older Chinese population.</div></div><div><h3>Methods</h3><div>A total of 5134 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were recruited. Cox proportional-hazards models were used to assess the association of changes in body mass index (BMI) and body fat percentage (BF%) with risk of all-cause mortality, using hazard ratios (HRs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Of the 5134 participants (median age, 81 years; 2716 women [52.90%]), 1494 deaths were observed over a median of 4.08 years of follow-up. Compared with participants with stable body size (change within 5%), those with more than a 10% decrease in BMI or BF% had 36% and 46% higher risks, respectively, of all-cause mortality (HR = 1.36, 95% CI: 1.17–1.59; and HR = 1.46, 95% CI: 1.25–1.72); also, those with more than a 10% increase in BMI or BF% had 22% and 17% higher risks of all-cause mortality (HR = 1.22, 95% CI: 1.05–1.41; and HR = 1.17, 95% CI: 1.02–1.35).</div></div><div><h3>Conclusions</h3><div>This prospective cohort study of older adults suggests that a dramatic change in body size was positively associated with a higher risk of all-cause mortality. More attention should be paid to the effects of a dramatic change in body size, particularly a dramatic decrease in body size, among the Chinese population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108252"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and performance of the new Guide for the Assessment of Menopausal Symptoms (GAMS) scale, based on the Greene Climacteric Scale: A population survey of French women","authors":"Alexandre Vallée ,&nbsp;Thomas Bozzo ,&nbsp;Maxence Arutkin ,&nbsp;Jean-Marc Ayoubi ,&nbsp;Pierre-François Ceccaldi","doi":"10.1016/j.maturitas.2025.108249","DOIUrl":"10.1016/j.maturitas.2025.108249","url":null,"abstract":"<div><h3>Objective</h3><div>The validity of the Greene Climacteric Scale (GCS) is supported by evidence demonstrating a strong correlation with other measures of menopausal symptoms and quality of life. However, this score, developed 60 years ago, may not be fully applicable the current menopausal population. The purpose of this study was to evaluate the validity of the GCS in a French population and to determine whether an alternative construction of the scale could improve its performance. This led to the development of a new tool: the Guide for the Assessment of Menopausal Symptoms (GAMS) scale.</div></div><div><h3>Methods</h3><div>The 21 questions of the GCS were distributed to French women via social media. The performance of the GCS score in identifying menopausal status was ascertained. Subsequently, the GAMS scale was developed using a training dataset and was validated on a separate dataset.</div></div><div><h3>Results</h3><div>The training dataset included data from 14,518 participants, of whom 3722 (26.64 %) were classified as menopausal. The validation dataset consisted of 3629 participants, of whom 852 (23.48 %) were menopausal. The GCS demonstrated an AUC of 0.53, with a median score of 20 [IQR: 14–27] for menopausal cases and a maximum probability of correct classification of 38 %. In comparison, the GAMS scale achieved an AUC of 0.63, with a median score of 4 [IQR: 2–7] and a maximum probability of correct classification of 70 %.</div></div><div><h3>Conclusion</h3><div>The performance of the GCS in identifying menopausal status is low. Applying weighting coefficients in the GAMS scale improves its performance. Further research is essential to develop tailored and specific menopausal scales that better address women's symptoms and improve their care.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108249"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heritability of bone mineral density among Japanese women: A twin study","authors":"Soichiro Saeki ,&nbsp;Rie Tomizawa ,&nbsp;Kaori Minamitani ,&nbsp;Ken Nakata ,&nbsp;Osaka Twin Research Group ,&nbsp;Chika Honda","doi":"10.1016/j.maturitas.2025.108251","DOIUrl":"10.1016/j.maturitas.2025.108251","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density.</div></div><div><h3>Methods</h3><div>The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density.</div></div><div><h3>Results</h3><div>The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72).</div></div><div><h3>Conclusions</h3><div>Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108251"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating skeletal wellness after breast cancer","authors":"Eleni Armeni","doi":"10.1016/j.maturitas.2025.108250","DOIUrl":"10.1016/j.maturitas.2025.108250","url":null,"abstract":"<div><div>Breast cancer is the leading cause of death in the female population. Hormone receptor-positive cancers are usually treated with surgery in combination with endocrine therapy. The latter is known to lower estrogen levels, contributing, therefore, to loss of bone density (BMD) and higher risk of fracture. Bone-modifying agents (BMAs) can regulate the bone-related adverse effects of cancer treatment. In premenopausal women, intravenous zoledronate effectively prevents bone loss. However, the evidence regarding its ability to reduce disease recurrence remains inconclusive. In postmenopausal women, denosumab demonstrates the most substantial evidence for fracture prevention, supported by one well-powered randomized controlled trial, but has not been shown to confer anticancer benefits. While bisphosphonates effectively prevent and reduce clinical vertebra fractures, their impact on overall fracture risk is unclear. In clinical practice, management of bone health in this group of patients starts with stratification for the risk of fracture. This can be done using the FRAX algorithm; measurements of bone mineral density can help to optimize stratification for individuals at higher fracture risk. Caution is advised when interpreting the results, as the FRAX algorithm has been considered to underestimate the true fracture risk in this population, given that the algorithm has not been adjusted for the effect of anti-cancer agents. Nowadays, clodronate, ibandronate, and zoledronic acid are recommended for bone protection in this group of patients, while denosumab is not. Further research is required to highlight the optimal BMA according to patient characteristics.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108250"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of ballistic vs conventional resistance training in healthy postmenopausal women: A three-arm parallel randomised controlled trial","authors":"Elisa A. Marques ,&nbsp;Ogulcan Caliskan ,&nbsp;Katherine Brooke-Wavell ,&nbsp;Jonathan Folland","doi":"10.1016/j.maturitas.2025.108246","DOIUrl":"10.1016/j.maturitas.2025.108246","url":null,"abstract":"<div><h3>Objectives</h3><div>Power training has gained attention as a method for enhancing functional performance and mitigating fall risk in older adults, yet its long-term feasibility and safety, particularly in ballistic resistance training, remain underexplored in postmenopausal women. We evaluated the feasibility of 8-month ballistic resistance training compared with conventional resistance training in postmenopausal women.</div></div><div><h3>Study design</h3><div>The Resistance Exercise Programme on Risk of Osteoporosis and Osteoarthritis in Females (REPROOF) study was a three-arm parallel group randomised controlled trial at a university lab in the UK. Healthy postmenopausal women (<em>n</em> = 109) were randomised to 30 weeks (2 sessions/week) of lower-body ballistic resistance training, conventional resistance training, or a non-exercising control group.</div></div><div><h3>Main outcome measures</h3><div>The primary outcomes, collected by questionnaire, were process feasibility, acceptability, perceived exercise efficacy, and adverse events.</div></div><div><h3>Results</h3><div>Eighty-two participants completed the trial (75.2 % retention). Both ballistic resistance training and conventional resistance training were well accepted, with most participants rating the intervention positively. No differences in the perceived improvements in physical function and psychological well-being were found between the resistance training groups. Similarly, there was no significant difference in the rate of muscle-related adverse events between the resistance training groups (ballistic, 2.7 per 100 person-weeks; conventional, 2.3 cases per 100 person-weeks), but the rate was significantly lower in the control group (0.9 cases per 100 person-weeks). No serious adverse events occurred during or within 24 h of exercise sessions.</div></div><div><h3>Conclusions</h3><div>The absence of serious adverse events and the observed positive outcomes confirm the safety, satisfaction, and perceived effectiveness of ballistic resistance training, suggesting its potential for broader application in healthy postmenopausal women.</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> registry ID <span><span>NCT05889598</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108246"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity accumulated across adulthood and vasomotor symptoms in pre, peri, and postmenopausal women aged 40–48","authors":"Jovenal Gama-Pinto,&nbsp;Gregore Iven Mielke","doi":"10.1016/j.maturitas.2025.108245","DOIUrl":"10.1016/j.maturitas.2025.108245","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the associations between physical activity accumulated through adulthood and vasomotor symptoms (hot flushes and night sweats) of menopause in women aged 40–48.</div></div><div><h3>Methods</h3><div>Data from 6569 women in the 1973–78 cohort of the Australian Longitudinal Study on Women's Health (ALSHW) were analysed in 2024. Physical activity data were collected every three years from age 22–28 to 43–48. Participants were classified into low, moderate, and high levels of cumulative physical activity based on their reported activity across the surveys. The main outcome was the occurrence of vasomotor symptoms, specifically hot flushes and night sweats, reported by participants at age 40–48.</div></div><div><h3>Results</h3><div>At age 40–48, 21.4 % reported hot flushes (26.6 % low, 20.7 % moderate, 20 % high activity), and 25.5 % reported night sweats (27.7 % low, 24.9 % moderate, 25.0 % high activity). Women with moderate levels of cumulative physical activity from their early 30s to early 40s had 20 % lower odds of experiencing hot flushes than those with low activity levels (OR: 0.80, 95 % CI: 0.67–0.95). This association remained statistically significant after adjusting for sociodemographic factors (OR: 0.83, 95 % CI: 0.69–0.99) but was no longer significant after further adjustment for health-related factors, including alcohol consumption, body mass index, menopausal status, self-rated health, anxiety, and depression. No significant associations were found between cumulative physical activity and vasomotor symptoms for other life stages.</div></div><div><h3>Conclusions</h3><div>Although overall cumulative physical activity levels were not associated with vasomotor symptoms, moderate physical activity levels accumulated from the early 30s to early 40s were associated with lower odds of experiencing hot flushes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108245"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}