Maturitas最新文献

{"title":"Menopause and arterial stiffness index: insights from the women's UK Biobank cohort","authors":"Alexandre Vallée","doi":"10.1016/j.maturitas.2025.108608","DOIUrl":"10.1016/j.maturitas.2025.108608","url":null,"abstract":"<div><h3>Background</h3><div>Menopause is a significant physiological transition characterized by hormonal changes that can influence cardiovascular health. One key concern is increased arterial stiffness, a predictor of cardiovascular disease and adverse cardiovascular events. However, the independent association between menopause and arterial stiffness, beyond traditional cardiovascular risk factors, remains unclear. This study investigates the relationship between menopause and arterial stiffness index in the women's UK Biobank cohort.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 52,891 women from the UK Biobank with measurements of arterial stiffness index. Arterial stiffness index was assessed using a non-invasive photoplethysmographic method. Multiple linear and logistic regression models were used to examine the association between menopause status and arterial stiffness index (continuous and cutoff&gt;10 m/s), adjusting for age, body mass index, antihypertensive medication use, income, education, dyslipidemia, alcohol consumption, chronic kidney disease, smoking, diabetes, heart rate, mean blood pressure, hormone therapy, and previous cardiovascular disease.</div></div><div><h3>Results</h3><div>Postmenopausal women had significantly higher values of arterial stiffness index (9.10 ± 4.61 m/s) than premenopausal women (7.76 ± 2.72 m/s, p &lt; 0.001). Menopause was independently associated with increased arterial stiffness index (B = 0.22, 95 % CI [0.16–0.28], p &lt; 0.001) and a higher odds ratio for arterial stiffness index &gt;10 m/s (OR = 1.41, 95 % CI [1.31–1.51], p &lt; 0.001), after adjusting for confounders.</div></div><div><h3>Conclusion</h3><div>Menopause is significantly associated with increased arterial stiffness, independent of traditional cardiovascular risk factors. These findings highlight menopause as a critical period for cardiovascular health assessment and prevention strategies.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108608"},"PeriodicalIF":3.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of anorexia of aging: A systematic review and meta-analysis","authors":"Shirley Steffany Muñoz Fernandez ,&nbsp;Gabriela Cabett Cipolli ,&nbsp;Reshma Aziz Merchant ,&nbsp;Virgílio Garcia Moreira ,&nbsp;Tatiana Klompenhouwer ,&nbsp;Andreia Pain ,&nbsp;Sandra Maria Lima Ribeiro ,&nbsp;Gustavo Duque ,&nbsp;Jürgen Bauer ,&nbsp;Francesco Landi ,&nbsp;Tommy Cederholm ,&nbsp;Ivan Aprahamian","doi":"10.1016/j.maturitas.2025.108603","DOIUrl":"10.1016/j.maturitas.2025.108603","url":null,"abstract":"<div><div>Anorexia of aging is a major geriatric syndrome that contributes to the development of malnutrition, frailty, and other adverse health outcomes, including death. However, its prevalence has not been clearly established. We examined the scientific literature to estimate the global prevalence and incidence of anorexia of aging, and its trends based on diagnostic tools, settings, and geographical location. A systematic search was conducted in PubMed, Scopus, Web of Science, and EMBASE from the date of database inception to July 2024. Observational cross-sectional and longitudinal studies in adults aged 60 years or more reporting the prevalence of anorexia of aging were included. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Random-effects meta-analysis was used to estimate the pooled effects. A total of 40 studies were included in the systematic review. Among these, 36 studies with a total sample size of 29,864,296 individuals were included in the meta-analysis. The overall pooled prevalence of anorexia of aging was 22.7 %, and its incidence was 3.78 %. This prevalence estimate remained relatively steady from 2011 to 2024. The highest prevalence was found in the inpatient population, at 34.7 %, and the most used tool was the Simplified Nutritional Appetite Questionnaire. A significantly higher prevalence was observed in South America, at 27.1 %. Our findings highlight that, globally, more than one-fifth of older populations had anorexia of aging, and they illustrate the need for a global consensus on its diagnosis.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108603"},"PeriodicalIF":3.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mortality and the ratio of red blood cell distribution width to albumin concentration in pre-hypertension and hypertension: A population-based cohort study","authors":"Haobiao Liu ,&nbsp;Zhuohang Chen","doi":"10.1016/j.maturitas.2025.108604","DOIUrl":"10.1016/j.maturitas.2025.108604","url":null,"abstract":"<div><h3>Objectives</h3><div>The ratio of red blood cell distribution width to albumin concentration (RAR) is a novel indicator of systemic inflammation and nutritional status. Its association with mortality in pre-hypertensive and hypertensive individuals remains unexplored.</div></div><div><h3>Methods</h3><div>This study investigates the relationship between RAR and all-cause as well as cause-specific mortality in a pre-hypertensive and hypertensive population using data from the National Health and Nutrition Examination Survey. Cox proportional hazard models assessed the relationship between RAR and mortality, with results reported as hazard ratios (HRs) and corresponding confidence intervals (CIs). Kaplan-Meier survival curves illustrated survival probabilities across quartiles, while restricted cubic spline (RCS) analysis examined potential non-linear associations.</div></div><div><h3>Results</h3><div>Elevated RAR was significantly associated with an increased risk of mortality. Each one-unit increase in RAR corresponded to an adjusted HR of 2.03 (95 % CI: 1.85–2.23) for all-cause mortality, 2.21 (95 % CI: 1.99–2.45) for heart disease, 1.86 (95 % CI: 1.65–2.10) for cancer, and 2.03 (95 % CI: 1.83–2.24) for other-cause mortality (<em>P</em> &lt; 0.001). Participants in the highest RAR quartile had a 178 % increased risk of all-cause mortality (HR = 2.78, 95 % CI: 2.51–3.08). Kaplan-Meier curves depicting the survival probabilities of pre-hypertensive and hypertensive participants across RAR quartiles substantiated these associations. RCS analysis also confirmed a positive association, demonstrating distinct linear or non-linear patterns in the associations with all-cause and cause-specific mortality.</div></div><div><h3>Conclusions</h3><div>RAR is independently associated with all-cause and cause-specific mortality in adults with pre-hypertension and hypertension, warranting its consideration for clinical risk stratification.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108604"},"PeriodicalIF":3.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring geriatricians' perspectives on aging biomarkers: A reflexive thematic analysis","authors":"Lieke Kuiper ,&nbsp;Roy Helthuis ,&nbsp;Harmke Polinder-Bos ,&nbsp;Lidwien Lemmens ,&nbsp;Martijn Dollé ,&nbsp;Eline Slagboom ,&nbsp;Jeroen van Rooij ,&nbsp;Monique Verschuren ,&nbsp;Joyce van Meurs","doi":"10.1016/j.maturitas.2025.108601","DOIUrl":"10.1016/j.maturitas.2025.108601","url":null,"abstract":"<div><h3>Objectives</h3><div>Aging biomarkers have been developed to identify people at higher risk of age-related decline. The objective of this study is to understand geriatricians' perspectives on aging biomarkers in order to facilitate their integration into geriatric medicine.</div></div><div><h3>Study design</h3><div>Using reflexive thematic analysis, this qualitative study explores the views of geriatricians on the potential role of aging biomarkers in clinical practice based on thirteen semi-structured interviews.</div></div><div><h3>Main outcome measures</h3><div>Geriatricians' views on the role, utility, and challenges of the use of aging biomarkers in geriatric medicine.</div></div><div><h3>Results</h3><div>Two main themes were developed: the complexity of geriatric medicine and the importance of trust in biomarkers. Clinicians highlighted the heterogeneity of the older patient population, noting that current assessments, such as the Comprehensive Geriatric Assessment (CGA), rely on the geriatricians' clinical judgment. While most participants saw potential for aging biomarkers to supplement the CGA in assessment of patients' resilience in recovery from invasive treatment, they emphasized the need to prove value beyond current treatment decisions. Furthermore, participants stressed the need for actionable, reliable, and context-specific tools. Concerns included the risk of oversimplifying the assessment of resilience, lack of applicability to the frail clinical population, and the ethical implications for both health care and society more broadly in the implementation of aging biomarkers.</div></div><div><h3>Conclusions</h3><div>This study emphasizes the importance of aligning biomarker development with the reality of geriatric medicine and clinicians' needs. Efforts from geriatricians, aging biomarker researchers, ethicists, and primary treating physicians are needed to successfully adopt aging biomarkers into geriatric medicine.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108601"},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Efficacy and safety of fezolinetant and elinzanetant for vasomotor symptoms in postmenopausal women: A systematic review and meta-analysis”","authors":"Rüyam Ercenk,&nbsp;İbrahim Karaca","doi":"10.1016/j.maturitas.2025.108602","DOIUrl":"10.1016/j.maturitas.2025.108602","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108602"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of menopause on the associations between dietary intake and the 20-year incidence of cardiovascular disease in women: the ATTICA cohort study (2002−2022)","authors":"Evangelia G. Sigala ,&nbsp;Christina Chrysohoou ,&nbsp;Fotios Barkas ,&nbsp;Evangelos Liberopoulos ,&nbsp;Petros P. Sfikakis ,&nbsp;Christos Pitsavos ,&nbsp;Costas Tsioufis ,&nbsp;Demosthenes Panagiotakos","doi":"10.1016/j.maturitas.2025.108600","DOIUrl":"10.1016/j.maturitas.2025.108600","url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of this study was to elucidate associations between incident cardiovascular disease and dietary risk factors in women classified by their menopausal status.</div></div><div><h3>Study design</h3><div>The ATTICA Study is a prospective cohort study initiated in 2001–2002 with a representative sample of 3042 adults (mean age 45 years) from the Attica region (Greece); follow-up examinations were performed after 5, 10, and 20 years Of the participants, 1528 (50.2 %) were women, of whom 65 % had not experienced menopause (35 % were in postmenopause at baseline). The sample for the present analysis comprised the 1001 women who had undergone cardiovascular assessment at the 20-year follow-up. Dietary habits were assessed through a validated food frequency questionnaire; the MedDietScore (range 0–55) evaluated adherence to the Mediterranean dietary pattern.</div></div><div><h3>Main outcome measures</h3><div>Cumulative fatal and non-fatal incidence of cardiovascular disease.</div></div><div><h3>Results</h3><div>Compared with women before menopause, postmenopausal women had an unfavorable risk profile for cardiovascular disease -including dietary habits- at baseline examination, which was not fully explained by age. At the 20-year follow-up, postmenopausal women exhibited a higher cumulative incidence of cardiovascular disease (post-menopause: 813/1000; before-menopause: 71/1000; <em>p</em>-value = 0.011); age-adjusted analysis revealed that postmenopausal women had a 4.38 times (95 % CI 2.08, 9.21) higher risk of cardiovascular disease, compared with their counterparts. Higher MedDietScore was associated with a significant reduction in the 20-year risk of cardiovascular disease, with more prominent associations observed among postmenopausal women.</div></div><div><h3>Conclusion</h3><div>These findings highlight the urgent need for targeted public health initiatives to encourage preventive dietary strategies in women from an early age.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108600"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive activity levels associated with dementia risk in older adults with social frailty: A longitudinal study","authors":"Fumio Sakimoto ,&nbsp;Takehiko Doi ,&nbsp;Kouki Tomida ,&nbsp;Soichiro Matsuda ,&nbsp;Keitaro Makino ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.maturitas.2025.108597","DOIUrl":"10.1016/j.maturitas.2025.108597","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the association between the level of engagement in cognitive activities and the risk of incident dementia among community-dwelling older adults with social frailty.</div></div><div><h3>Study design</h3><div>This prospective cohort study included 2725 adults aged 60 or more without dementia at baseline.</div></div><div><h3>Main outcome measures</h3><div>Social frailty was based on five items: living alone, going out less frequently than in the previous year, not visiting friends, not feeling useful to family and friends, and not conversing with someone every day. Participants meeting two or more of these criteria were defined as having social frailty. Cognitive activities comprised 12 items according to the frequency of implementation. Four groups were created by combining social frailty status and cognitive activity levels. The Cox proportional hazards model was used to analyze the relationship between the combination of social frailty and cognitive activity and the incidence of dementia at 60 months.</div></div><div><h3>Results</h3><div>Compared with the group without social frailty and with high engagement in cognitive activity, the group with social frailty and low engagement had a significantly higher risk of dementia. However, the former group showed a reduction in the risk of dementia.</div></div><div><h3>Conclusions</h3><div>High engagement in cognitive activities was found to be associated with a reduced risk of dementia, even in the context of social frailty. Cognitive activities that are feasible for solitary execution have the potential to benefit older adults experiencing challenges with social participation.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108597"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between leg-to-trunk lean mass ratio measured by dual-energy X-ray absorptiometry and later falls in older Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study","authors":"Akihiro Takada ,&nbsp;Katsuyasu Kouda ,&nbsp;Yuki Fujita ,&nbsp;Kumiko Ohara ,&nbsp;Takahiro Tachiki ,&nbsp;Junko Tamaki ,&nbsp;Jong-Seong Moon ,&nbsp;Etsuko Kajita ,&nbsp;Jun Kitagawa ,&nbsp;Nozomi Okamoto ,&nbsp;Masayuki Iki","doi":"10.1016/j.maturitas.2025.108596","DOIUrl":"10.1016/j.maturitas.2025.108596","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia, defined as “decreased lean mass (LM) plus low muscle strength and/or low physical performance,” is associated with a high risk of falls and fractures. Although an association between muscle strength and falls has been reported, the association between LM and falls remains unclear, with previous studies reporting conflicting findings. We investigated the association of LM measured precisely by dual-energy X-ray absorptiometry with later falls in community-dwelling Japanese men aged 65 years or more at the time of the baseline survey.</div></div><div><h3>Methods</h3><div>The present analyses included 507 older men who provided complete information on LM and falls in the Fujiwara-kyo Osteoporosis Risk in Men cohort study. Whole-body LM and regional LM were measured from 2017 to 2019. LM in each body region, including the legs and trunk, was recorded. The leg-to-trunk LM ratio, calculated as leg LM divided by trunk LM, was also analyzed. Information on falls that occurred in the 12 months prior to the 2022–2023 follow-up survey was obtained.</div></div><div><h3>Results</h3><div>Mean trunk LM was significantly larger, and mean leg-to-trunk LM ratio significantly smaller, in fallers than in non-fallers (P &lt; 0.05). Multiple logistic regression analysis revealed that leg-to-trunk LM ratio was significantly inversely associated with falls after adjusting for potential confounders (P &lt; 0.05), whereas no significant associations were observed between whole-body and regional LM and falls.</div></div><div><h3>Conclusion</h3><div>Leg-to-trunk LM ratio was associated with later falls in community-dwelling older Japanese men. Older men with a larger distribution of leg LM relative to trunk LM tended to have a lower risk of later falls.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108596"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause is associated with a reduction in glomerular filtration rate, independent of body composition and metabolic syndrome","authors":"Alessandro Leone ,&nbsp;Francesca Menichetti ,&nbsp;Federica Sileo ,&nbsp;Silvia Gallosti ,&nbsp;Ramona De Amicis ,&nbsp;Andrea Foppiani ,&nbsp;Simona Bertoli ,&nbsp;Alberto Battezzati","doi":"10.1016/j.maturitas.2025.108595","DOIUrl":"10.1016/j.maturitas.2025.108595","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the relationship between menopause and glomerular filtration rate (GFR), independent of body composition and metabolic profile, both known risk factors for GFR decline.</div></div><div><h3>Study design</h3><div>Cross-sectional study involving 3918 women aged 40–55 years.</div></div><div><h3>Main outcome measures</h3><div>Participants provided information about medical history, menopausal status, and current medication use. Participants underwent nutritional and anthropometric assessments. Blood samples were collected to measure biochemical parameters. Menopause was defined as no menstrual cycle for 12 months or more. GFR was estimated using the EPI-CKD formula, and metabolic syndrome was identified using harmonized criteria. Premenopausal and postmenopausal women were matched by age, body composition, and metabolic syndrome factors to assess the menopause–GFR association.</div></div><div><h3>Results</h3><div>Postmenopausal women exhibited higher fat mass, lower fat-free mass, and reduced GFR compared with premenopausal women. They also had higher rates of hypertension, impaired fasting glucose, and metabolic syndrome. After matching for age, fat mass index, fat-free mass index, and components of the metabolic syndrome, menopause was independently associated with a GFR reduction of 2.32 ml/min/1.73m² (95 % CI: −3.81, −0.83). Additionally, menopause was linked to a 51 % higher risk of GFR &lt;90 ml/min/1.73m² (OR = 1.51; 95 % CI 1.12, 2.02).</div></div><div><h3>Conclusions</h3><div>Menopause represents an independent risk factor for GFR decline, beyond the effects related to body composition and metabolic risk factors.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108595"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning models to predict decline in intrinsic capacity among older adults in China: a prospective cohort study","authors":"Runjie Sun,&nbsp;Yijing Li,&nbsp;Yanru Kang,&nbsp;Xinqi Xu,&nbsp;Jie Zhu,&nbsp;Haiyan Fu,&nbsp;Yining Zhang,&nbsp;Jingwen Lin,&nbsp;Yongbing Liu","doi":"10.1016/j.maturitas.2025.108594","DOIUrl":"10.1016/j.maturitas.2025.108594","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring intrinsic capacity and implementing appropriate interventions can support healthy aging. There are, though, few tools available for predicting decline in intrinsic capacity among older adults. This study aimed to develop and validate an interpretable machine learning model designed to identify populations at elevated risk of a decline in intrinsic capacity.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study baseline (2011) and 4-year follow-up (2015), a total of 822 participants were randomly allocated to a training set and a testing set at a 7:3 ratio. Five machine learning methods were employed to train the model and assess its performance through various metrics. The SHapley Additive exPlanation method was subsequently used to interpret the optimal model.</div></div><div><h3>Results</h3><div>The 4-year incidence of decline in intrinsic capacity among the older adults in the sample was 44.6 % (<em>n</em> = 367). Nine variables were screened for model construction, among which eXtreme gradient boosting demonstrated the best predictive performance, achieving an area under the receiver operating characteristic curve (AUC) of 0.715 (95 % CI 0.651–0.780) in the testing set. The SHapley Additive exPlanation method identified educational level, smoking, handgrip strength, self-rated health, and residence as the top five significant predictors.</div></div><div><h3>Conclusions</h3><div>The developed model can serve as a highly effective tool for primary care teams to identify older adults with early signs of decline in intrinsic capacity, facilitating the provision of subsequent screening and tailored interventions for intrinsic capacity.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108594"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}