Maturitas最新文献

{"title":"Associations of life's essential 8 and life's crucial 9 scores with all-cause and cardiovascular mortality: A population-based cohort study of postmenopausal women","authors":"Jun Wei ,&nbsp;Ye Xu ,&nbsp;Yang Liu","doi":"10.1016/j.maturitas.2025.108753","DOIUrl":"10.1016/j.maturitas.2025.108753","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the associations of scores on the Life's Essential 8 (LE8) and Life's Crucial 9 (LC9) scales with all-cause and cardiovascular mortality among postmenopausal women in the United States.</div></div><div><h3>Methods</h3><div>We analyzed data from 5499 postmenopausal women aged ≥20 years from the 2005–2014 National Health and Nutrition Examination Survey (NHANES), linked to mortality data through December 31, 2019. LE8 includes four behavioral and four clinical metrics; LC9 adds psychological well-being. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause mortality. Generalized additive models explored dose–response relationships. Kaplan–Meier curves and log-rank tests assessed survival differences across score tertiles.</div></div><div><h3>Results</h3><div>During a median follow-up of 64 months, 1154 deaths occurred (20.99 %), including 358 (31.0 %) from cardiovascular causes. Mean LC9 score was 63.7 (SD = 14.2). Each 1-SD increase in LE8 and LC9 scores was associated with a 27 % (HR = 0.73, 95 % CI: 0.68–0.78) and 30 % (HR = 0.70, 95 % CI: 0.66–0.76) lower risk of all-cause mortality, respectively. Compared with the lowest tertiles, the highest tertiles of LE8 and LC9 were associated with 50 % (HR = 0.50, 95 % CI: 0.43–0.59) and 51 % (HR = 0.49, 95 % CI: 0.41–0.57) lower risks. Dose–response curves showed inverse, approximately linear associations. Kaplan–Meier survival curves showed significantly higher survival probabilities among participants with higher LE8 and LC9 scores (log-rank <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Higher LE8 and LC9 scores were associated with lower all-cause and cardiovascular mortality among postmenopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108753"},"PeriodicalIF":3.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between chronic pain and the clustering of menopausal symptoms: Evidence from a British birth cohort study","authors":"Catherine Borra ,&nbsp;Rebecca Hardy","doi":"10.1016/j.maturitas.2025.108756","DOIUrl":"10.1016/j.maturitas.2025.108756","url":null,"abstract":"<div><h3>Background</h3><div>Cross-sectional studies have demonstrated an association between menopausal symptoms and chronic pain, but the direction of the association remains unknown. We assessed whether chronic pain is associated with subsequent clusters of menopausal symptoms.</div></div><div><h3>Methods</h3><div>We used data from the National Child Development Study, a birth cohort of people born in 1958 in England, Scotland and Wales, which has included a biomedical sweep at age 44 when chronic pain was assessed and a 20-item menopause symptom questionnaire at age 50. Chronic pain was defined as lasting longer than 3 months, and chronic widespread pain was defined as chronic contralateral upper and lower quadrant pain and spinal pain. Latent class analysis was used to define menopause symptom classes (<em>n</em> = 4897) and structural equation models (<em>n</em> = 3308) to relate chronic pain and chronic widespread pain to these classes, adjusting for confounding variables.</div></div><div><h3>Results</h3><div>We found four latent classes of menopause symptom experience at 50 years. These were a low symptom burden class, one defined by vasomotor symptoms, one by psychological symptoms and one with high symptom burden. Chronic pain and chronic widespread pain at 44 years were related to greater odds of being in the higher symptom burden classes compared with the low burden group. For example, the odds ratio (95 % confidence interval) for the high symptom burden class was 2.90 (2.21, 3.81) for chronic pain and 3.50 (2.23, 5.49) for chronic widespread pain, and for the vasomotor symptom class 1.50 (1.16, 1.94) for chronic pain and 1.93 (1.19, 3.13) for chronic widespread pain.</div></div><div><h3>Conclusion</h3><div>Women with chronic pain and chronic widespread pain earlier in life may experience greater burden of menopausal symptoms and this should be considered in their clinical management.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108756"},"PeriodicalIF":3.6,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uterus debate in vaginal native tissue repair for pelvic organ prolapse: Hysteropexy versus hysterectomy – A systematic review and meta-analysis","authors":"Alessandro Ferdinando Ruffolo ,&nbsp;Stefano Salvatore ,&nbsp;Marco Torella ,&nbsp;Matteo Frigerio ,&nbsp;Marco Soligo ,&nbsp;Chrystele Rubod ,&nbsp;Marine Lallemant ,&nbsp;Michel Cosson ,&nbsp;Maurizio Serati ,&nbsp;Andrea Braga","doi":"10.1016/j.maturitas.2025.108755","DOIUrl":"10.1016/j.maturitas.2025.108755","url":null,"abstract":"<div><h3>Introduction</h3><div>Pelvic organ prolapse is a common condition with significant impact on women’s quality of life. Following restrictions on transvaginal mesh, native tissue repair has re-emerged as the mainstay of vaginal prolapse surgery. The role of hysterectomy in apical prolapse repair remains debated, with uterus-preserving techniques proposed as less invasive alternatives.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis according to PRISMA guidelines (PROSPERO CRD420251132469). Studies comparing vaginal hysterectomy with sacrospinous or uterosacral hysteropexy in native tissue repair were included. Primary outcomes were apical recurrence, global anatomical success, subjective success, and reoperation rates. Secondary outcomes included operative time, blood loss, hospital stay, and major complications. Random-effects models were used for statistical pooling.</div></div><div><h3>Results</h3><div>Sixteen studies involving 2544 women (1364 hysterectomy, 1180 hysteropexy) were analyzed. Pooled results showed no significant difference between hysterectomy and hysteropexy for apical recurrence (OR 0.60, 95 % CI 0.30–1.19), global anatomical success (OR 1.33, 95 % CI 0.88–2.02), subjective success (OR 0.92, 95 % CI 0.63–1.34), or reoperation rates (OR 1.04, 95 % CI 0.56–1.96). Similarly, no difference was observed in major complications (Clavien-Dindo ≥ III). However, hysterectomy was associated with longer operative time (+29 min), greater blood loss (+80 mL), and longer hospital stay (+1.1 days.</div></div><div><h3>Conclusions</h3><div>In vaginal native tissue repair for pelvic organ prolapse, hysterectomy and hysteropexy provide comparable anatomical and functional outcomes, as well as similar safety and reintervention rates. Hysteropexy appears advantageous in reducing perioperative morbidity and resource use, supporting its role as an effective, uterus-preserving alternative to hysterectomy.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108755"},"PeriodicalIF":3.6,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145365945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in proteinuria and the risk of urogenital cancer in Korean men","authors":"Dong-Young Lee ,&nbsp;Min-Ho Kim ,&nbsp;Eunhee Ha ,&nbsp;Soonsu Shin ,&nbsp;Sungjin Kim ,&nbsp;Dosang Cho ,&nbsp;Ah Rah Lee ,&nbsp;Jae-Hong Ryoo","doi":"10.1016/j.maturitas.2025.108754","DOIUrl":"10.1016/j.maturitas.2025.108754","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the association between changes in proteinuria and the incidence of urogenital cancer (prostate, kidney, and bladder cancer) in Korean men.</div></div><div><h3>Methods</h3><div>We analyzed data from 1,225,646 Korean men who underwent health check-ups in 2005–2006 and 2009. Proteinuria changes were categorized into four groups based on urine dipstick tests: persistently negative, resolved, incident, and persistent proteinuria. The relationship between these groups and the incidence of urogenital cancer over follow-up through to 2021 was assessed using multivariate Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Persistent proteinuria was associated with the highest risk of urogenital cancer (hazard ratio (HR) 1.323, 95 % confidence interval (CI) 1.190–1.472), followed by incident proteinuria (HR 1.155, 95 % CI 1.096–1.217). Kidney cancer risk was elevated in persistent (HR 2.312, 95 % CI 1.853–2.885), incident (HR 1.346, 95 % CI 1.171–1.546), and resolved (HR 1.293, 95 % CI 1.066–1.568) proteinuria groups. Bladder cancer risk increased in the incident proteinuria group (HR 1.425, 95 % CI 1.289–1.576). Resolved proteinuria was linked to a reduced risk of prostate cancer (HR 0.878, 95 % CI 0.796–0.968).</div></div><div><h3>Conclusion</h3><div>The incidence of urogenital cancer was significantly higher for persistent proteinuria and (to a lesser degree) incident proteinuria than for persistently negative or resolved proteinuria. The risk of kidney cancer was similar to that of urogenital cancer, while other cancers had weaker associations with proteinuria. The results highlight the importance of monitoring proteinuria regularly for urogenital cancer risk assessment.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108754"},"PeriodicalIF":3.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone use by people with dementia: An exploratory survey","authors":"Amber Sacre ,&nbsp;Conor Wall ,&nbsp;Alan Godfrey ,&nbsp;Victoria Hetherington ,&nbsp;Andrew Byrne ,&nbsp;Robert Barber","doi":"10.1016/j.maturitas.2025.108751","DOIUrl":"10.1016/j.maturitas.2025.108751","url":null,"abstract":"<div><h3>Introduction</h3><div>Digital technologies are increasingly used in the delivery of health and social care, and by the public, to foster a decentralised approach to healthcare provision and encourage self-management. If new technologies and related innovations are to support people with dementia, it is important to understand the views and needs of people with dementia alongside those of their carers, but this is an under-researched area. This study focuses on how smartphones are used by people with dementia and their carers.</div></div><div><h3>Objectives</h3><div>To undertake a national survey of people with dementia and their carers to explore their experiences and opinions relating to the use of smartphones by people with dementia.</div></div><div><h3>Study design</h3><div>We conducted a cross-sectional survey (12 questions) with participants recruited via two UK-based dementia research registries. Descriptive and inferential statistics assessed smartphone ownership, usage patterns, and challenges.</div></div><div><h3>Results</h3><div>There were 719 respondents (276 people with dementia, 443 carers). Amongst smartphone owners (47.7 %), only 39.4 % used these devices for dementia management: 89 people with dementia and 19 carers (reporting for people with dementia), mainly for memory support. Overall, 52.8 % used smartphones for safety and independence, primarily specifically for communication (128 people with dementia, 44 carers). Key barriers included setup difficulty (people with dementia) and complexity concerns (non-owners), with moderate concerns over fraud and theft.</div></div><div><h3>Conclusion</h3><div>Smartphones are underused in dementia care. Improving usability, nuanced smartphone functionality (and app co-design), and enhancing accessibility are essential to reducing digital exclusion and improving care engagement.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"203 ","pages":"Article 108751"},"PeriodicalIF":3.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement and brain health in perimenopausal and early postmenopausal females: A scoping review","authors":"Wejdaan Faridi ,&nbsp;Julia T. Daun ,&nbsp;Tana Dhruva ,&nbsp;Emma McLaughlin ,&nbsp;Imrose Bhullar ,&nbsp;Genoa Bolianatz ,&nbsp;Elaine Gentleman ,&nbsp;K. Alix Hayden ,&nbsp;S. Nicole Culos-Reed ,&nbsp;Meghan H. McDonough ,&nbsp;Cindy K. Barha","doi":"10.1016/j.maturitas.2025.108747","DOIUrl":"10.1016/j.maturitas.2025.108747","url":null,"abstract":"<div><h3>Introduction</h3><div>The menopause transition is associated with dramatic fluctuations and eventual decline in levels of ovarian hormones, leading to loss of neuroprotection, marking this as an important intervention period for brain health promotion in females. Physical activity and exercise can improve brain health in older, postmenopausal females. Whether movement (physical activity and exercise) can protect brain health in perimenopausal and early postmenopausal females is not clear.</div></div><div><h3>Objective</h3><div>The objective of this scoping review was to map the literature examining the relationship between movement and brain health in perimenopausal and early postmenopausal females, with a focus on identifying key methodological approaches and gaps in the knowledge.</div></div><div><h3>Inclusion criteria</h3><div>This scoping review considered studies of any design that included a movement component with a primary focus on perimenopausal females and secondary focus on early postmenopausal females, with a brain health outcome.</div></div><div><h3>Methods</h3><div>This scoping review followed JBI recommendations and methodology and the PRISMA-ScR reporting guidelines. The following databases were searched: Medline All (OVID), Embase (OVID), APA PsycInfo (OVID), Scopus (Elsevier), CINAHL (Ebsco), and SportDiscus (Ebsco). Details about participant population, study methods, and key findings were extracted.</div></div><div><h3>Results</h3><div>Of the 30,927 identified records, 19 studies were included in the synthesis, with 3 studies conducted with only perimenopausal females, 8 studies with only early postmenopausal females, and 8 studies with a mixed cohort. Aerobic training was the most common form of movement (<em>n</em> = 7) and executive function was the most common brain health outcome measured (<em>n</em> = 12). Benefits of movement on brain health were seen in 13 studies (68.4%).</div></div><div><h3>Conclusion</h3><div>In this scoping review, we cover the limited research published to date that explores movement and brain health in perimenopausal and early postmenopausal females. While current research provides promising support for the effectiveness of exercise and physical activity to promote brain health during this period of the lifespan, more high-quality studies in perimenopause are needed with standardized reproductive staging and comprehensive brain health and menopausal symptom measures to establish the effectiveness of exercise during this critical neuro-aging period.</div></div><div><h3>Protocol registration</h3><div>doi: <span><span>10.17605/OSF.IO/F52JR</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108747"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of duration of hormonal contraceptive use on breast cancer risk: a systematic review and meta-analysis of cohort studies","authors":"Carmen Sayon-Orea ,&nbsp;Andrea Romanos-Nanclares ,&nbsp;Vanessa Bullón-Vela ,&nbsp;Ignacio Chiva-San Roman ,&nbsp;Benedita Caiado ,&nbsp;Maria Ondarra-Erdozain ,&nbsp;Miguel Delgado-Rodriguez ,&nbsp;Miguel A. Martínez-González","doi":"10.1016/j.maturitas.2025.108750","DOIUrl":"10.1016/j.maturitas.2025.108750","url":null,"abstract":"<div><div>We conducted a systematic review and meta-analysis on the prospective evidence for the association between use of hormonal contraceptives for 5 years or more and the subsequent incidence of breast cancer. We systematically searched all cohort studies published in English, Spanish, Italian, French, or Portuguese on PubMed or Web of Science up to September 8, 2025. We used Covidence software to manage most review activities. We extracted relative risks, odds ratios, or hazard ratios from each individual study to generate pooled results using a random-effects meta-analysis, and a dose–response meta-analysis to calculate relative risks and their 95 % confidence intervals for each additional year of use of hormonal contraceptives. The Newcastle-Ottawa Scale was applied to assess the quality of included studies. Several subgroup and sensitivity analyses were conducted. Twenty independent cohorts and 23 reports with a total of 5,572,683 women and 72,350 incident cases of breast cancer were included in the systematic review, while 3,920,319 women with 68,508 incident cases were included in the meta-analysis. The pooled adjusted relative risk for the association between hormonal contraceptive use for 5 years or more and breast cancer risk was 1.20 (95 % confidence interval, 1.09–1.32) compared with never users. Further meta-analyses on the dose–response relationship showed a nonlinear association, with risk progressively increasing during the first 5 years of use, after which the risk remained stable until the 10th year, when it increased again. This meta-analysis provides evidence of a detrimental association between duration of exposure to oral contraceptives and breast cancer risk.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108750"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic risk scores for breast cancer: Progress, challenges, and clinical integration","authors":"Jerry S. Lanchbury ,&nbsp;Holly J. Pederson","doi":"10.1016/j.maturitas.2025.108748","DOIUrl":"10.1016/j.maturitas.2025.108748","url":null,"abstract":"<div><div>In a previous commentary, “An apparent quandary: adoption of polygenics and gene panels for personalized breast cancer risk stratification,” we highlighted the exceptional progress that had been made uncovering the polygenic risk component underpinning breast cancer susceptibility and drew attention to the critical challenges inherent in translating these advancements into measurable improvements in clinical care. Among the barriers to adoption discussed were the inherent biases in polygenic risk scores (PRS) developed in populations of largely European descent, the unpreparedness of professional societies for adoption, and the lack of education of current healthcare professionals and the cadres of those emerging from training. In this update, we focus on the substantial research advances that have been made and the cultural and practical transitions that have begun to position the field for delivering personalized preventive breast cancer services to all women. It is our perception that the discussion has moved from questions of establishing scientific validity to a focus on the development and application of practical operational solutions to better stratify risk. Additional issues raised are concerns over misuse, the composition of the single nucleotide polymorphism (SNPs) panels used and adjustment for non-European populations. High-risk breast clinics will benefit dramatically from models that incorporate genome-wide susceptibility genetics. Improved risk estimation may aid in patients' decisions about preventive medication and in clinical decisions concerning the need for and frequency of MRI screening, and, in exceptional cases, may even help patients at hereditary risk with surgical decision-making.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108748"},"PeriodicalIF":3.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free testosterone and cognitive function: Sex-specific links in adults in the nationwide Korean frailty and aging cohort","authors":"Shin Who Park ,&nbsp;Woo Chul Son ,&nbsp;Miji Kim ,&nbsp;Chang Won Won ,&nbsp;Won Kim","doi":"10.1016/j.maturitas.2025.108745","DOIUrl":"10.1016/j.maturitas.2025.108745","url":null,"abstract":"<div><h3>Introduction</h3><div>Previous studies have examined the relationship between endogenous testosterone and cognitive function, but findings have been inconsistent. Additionally, the sex-specific effects of free testosterone (FT) on various cognitive domains in adults who are older, especially within Asian populations, remain under investigation.</div></div><div><h3>Methods</h3><div>This cross-sectional study involved 2710 Korean adults aged 70–84 participating in the Korean Frailty and Aging Cohort Study. Serum FT levels were measured and categorized into quartiles. Cognitive function was evaluated using the Mini-Mental State Examination – Korean version (MMSE-KC), the Korean version of the CERAD battery, Trail Making Test-A (TMT), Digit Span (DS), Word List Memory test, and the Frontal Assessment Battery (FAB). Multivariable logistic and quantile regression analyses were adjusted for age, education, lifestyle factors, depressive disorder, and physical performance.</div></div><div><h3>Results</h3><div>In women, lower FT levels were independently linked with impairments in the MMSE-KC, TMT, FAB, and Word List Memory test. Compared with higher FT quartiles, the lowest quartile had significantly increased odds ratios of 1.36, 1.34, 1.39, and 1.52 for these tests, respectively. Pairwise comparisons between quartiles showed that women in the lowest FT quartile performed significantly worse on the MMSE-KC and Word List Memory test than those in the highest quartile. In men, however, no significant associations were identified.</div></div><div><h3>Conclusions</h3><div>This population-based cross-sectional study of older Korean adults found that lower serum FT levels were independently associated with cognitive impairments across multiple domains in women but not men. These findings highlight FT's potential role in cognitive impairment, particularly among women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108745"},"PeriodicalIF":3.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and factors associated with potassium supplementation in older adults from general practices in Germany","authors":"Karel Kostev ,&nbsp;André Hajek ,&nbsp;Dong Keon Yon ,&nbsp;Razak M. Gyasi ,&nbsp;Louis Jacob","doi":"10.1016/j.maturitas.2025.108746","DOIUrl":"10.1016/j.maturitas.2025.108746","url":null,"abstract":"<div><h3>Objectives</h3><div>Little information exists on potassium supplementation in older adults living in the community. Therefore, this study investigated the prevalence of potassium supplementation and its associated factors in patients aged ≥65 years followed in general practices in Germany.</div></div><div><h3>Study design</h3><div>Retrospective.</div></div><div><h3>Main outcome measures</h3><div>The prevalence analysis was conducted on a sample of adults aged ≥65 years followed for at least 12 months in 1993 general practices in Germany between 2014 and 2023. The analysis focusing on the identification of factors associated with the prescription of potassium supplementation was done on two subsamples: individuals with (<em>n</em> = 38,517) and without potassium supplementation (n = 38,517) matched using a propensity score for age, sex, and the index year (i.e., date of first prescription for the potassium supplementation group and a random date for the no‑potassium supplementation group). Factors potentially associated with potassium supplementation were several diagnoses and prescriptions documented within 12 months before or at the index date.</div></div><div><h3>Results</h3><div>The prevalence of potassium supplementation was 4.4 % among 882,662 adults aged ≥65 years who were followed for at least 12 months in general practices. The proportion of people receiving potassium supplementation increased with age. The prescription of potassium supplementation was associated with multiple diagnoses and prescriptions, the strongest effect sizes being for hypokalemia (OR = 53.99), loop diuretics and thiazides (OR = 4.68), and hyperaldosteronism (OR = 3.38).</div></div><div><h3>Conclusions</h3><div>In this preliminary research, less than 5 % of older adults received potassium supplementation in primary care. More data are warranted to corroborate this figure in other settings.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108746"},"PeriodicalIF":3.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}