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Longitudinal changes in frailty and incident diabetes in middle-aged and older adults: evidence from CHARLS 中老年衰弱和糖尿病发病率的纵向变化:来自CHARLS的证据
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-29 DOI: 10.1016/j.maturitas.2025.108375
Xingge Li , Ruilang Lin , Lulu Pan , Yuwei Peng , Xiaorui Cui , Shiyuan Wang , Yongfu Yu
{"title":"Longitudinal changes in frailty and incident diabetes in middle-aged and older adults: evidence from CHARLS","authors":"Xingge Li ,&nbsp;Ruilang Lin ,&nbsp;Lulu Pan ,&nbsp;Yuwei Peng ,&nbsp;Xiaorui Cui ,&nbsp;Shiyuan Wang ,&nbsp;Yongfu Yu","doi":"10.1016/j.maturitas.2025.108375","DOIUrl":"10.1016/j.maturitas.2025.108375","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate how changes in frailty affect diabetes risk and whether sex and age influence this relationship.</div></div><div><h3>Study design</h3><div>This prospective cohort study, based on the China Health and Retirement Longitudinal Study (CHARLS), included 11,221 adults aged 45 and over without diabetes before the second survey. The frailty index (FI), with scores ranging from 0 to 1, was administered at baseline (2011) and during the second survey (2013), categorizing participants as robust (FI ≤ 0.10), pre-frail (FI 0.10–0.25), or frail (FI ≥ 0.25). Frailty changes were determined from the two assessments.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was incident diabetes. Cox regression was used to assess the association of frailty changes with diabetes and whether this association differed by sex and age (≤65 years and &gt;65 years).</div></div><div><h3>Results</h3><div>During a median 7-year follow-up, 1197 developed diabetes. Those remaining pre-frail/frail had nearly double the risk of diabetes (HR 1.99, 95 % CI 1.70-2.33) compared with those remaining robust. Progressing from robust to pre-frail/frail increased risk (HR 1.80, 95 % CI 1.48-2.19), and improving from pre-frail/frail to robust still had an elevated risk (HR 1.32, 95 % CI 1.06-1.66). Higher FI tertile changes were linked to increased diabetes risk (HR 1.44, 95 % CI 1.24-1.67), with a significant trend (P &lt; 0.001). Women were at higher risk (P = 0.004), but age did not significantly modify the association (P = 0.972).</div></div><div><h3>Conclusions</h3><div>Frailty progression is strongly linked to increased risk of diabetes, especially in women, highlighting the need for targeted frailty management in diabetes prevention.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108375"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body composition as an index of the trabecular bone score in postmenopausal women 身体成分作为绝经后妇女小梁骨评分的指标
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-26 DOI: 10.1016/j.maturitas.2025.108273
Maria Eleni Chondrogianni , Ioannis Kyrou , Theodoros Androutsakos , Maria Panagaki , Maria-Loukia Koutsompina , Nektaria Papadopoulou-Marketou , Despina Polichroniadi , Grigorios Kaltsas , Efstathios Efstathopoulos , Maria Dalamaga , Harpal S. Randeva , Eva Kassi
{"title":"Body composition as an index of the trabecular bone score in postmenopausal women","authors":"Maria Eleni Chondrogianni ,&nbsp;Ioannis Kyrou ,&nbsp;Theodoros Androutsakos ,&nbsp;Maria Panagaki ,&nbsp;Maria-Loukia Koutsompina ,&nbsp;Nektaria Papadopoulou-Marketou ,&nbsp;Despina Polichroniadi ,&nbsp;Grigorios Kaltsas ,&nbsp;Efstathios Efstathopoulos ,&nbsp;Maria Dalamaga ,&nbsp;Harpal S. Randeva ,&nbsp;Eva Kassi","doi":"10.1016/j.maturitas.2025.108273","DOIUrl":"10.1016/j.maturitas.2025.108273","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity is considered to exert a protective effect on bone mineral density (BMD). However, emerging data indicate that the effect of adipose tissue on bone health is much more complex. Trabecular bone score (TBS) provides information on bone texture and predicts fracture risk independently of BMD. This study investigated the association of body composition and bone quality as evaluated by lumbar spine (LS) TBS.</div></div><div><h3>Study design</h3><div>Cross-sectional study including 118 postmenopausal women (mean age 60.73 ± 8.97 years and mean BMI 28.36 ± 5.8) with no history of secondary osteoporosis or previous anti-osteoporotic treatment.</div></div><div><h3>Main outcome measures</h3><div>Body composition, BMD and LS TBS were evaluated by dual-energy X-ray absorptiometry (DXA). Τo explore the associations among the variables of interest, Spearman's correlations were used. Simple and multiple linear regression models were also applied to explore the associations among variables of interest.</div></div><div><h3>Results</h3><div>Visceral adipose tissue (VAT) mass, android fat mass and android/gynoid fat ratio were negative predictors of TBS (Stb = −0.413, <em>p</em> &lt; 0.001; Stb = −0.369, p &lt; 0.001; Stb = −0.333, p &lt; 0.001, respectively). Similarly, both the right (Stb = −0.313, p &lt; 0.001) and left arm fat mass (Stb = −0.313, p &lt; 0.001) were negative predictors of TBS. In a multiple linear regression model, VAT mass exhibited a significant negative association with TBS (Stb = −0.415, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The present study offers evidence that VAT mass has a negative association with bone texture as estimated by TBS in postmenopausal women. Moreover, the findings suggest that the body composition of the arms (arm fat mass) correlates inversely with the bone texture. Further research is required to validate these findings in large cohorts of postmenopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108273"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of physical activity on sleep in women experiencing vasomotor symptoms during menopause: a systematic review and meta-analysis 体育活动对绝经期血管舒缩症状女性睡眠的影响:一项系统综述和荟萃分析
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-23 DOI: 10.1016/j.maturitas.2025.108271
Adriano Bruno Corrêa, Mateus do Carmo Bardella, Arthur Polveiro da Silva, Matheus Martins Moreira, Luís Felipe Pengo Almeida Leite, Camila de Moraes
{"title":"Effect of physical activity on sleep in women experiencing vasomotor symptoms during menopause: a systematic review and meta-analysis","authors":"Adriano Bruno Corrêa,&nbsp;Mateus do Carmo Bardella,&nbsp;Arthur Polveiro da Silva,&nbsp;Matheus Martins Moreira,&nbsp;Luís Felipe Pengo Almeida Leite,&nbsp;Camila de Moraes","doi":"10.1016/j.maturitas.2025.108271","DOIUrl":"10.1016/j.maturitas.2025.108271","url":null,"abstract":"<div><div>Hot flashes and night sweats, common vasomotor symptoms (VMS) during menopause, are strongly associated with poor sleep quality and disorders. Physical activity is proposed as a strategy to improve menopausal health and sleep outcomes. This systematic review and meta-analysis synthesizes and evaluates evidence on the relationship between physical activity and sleep parameters in women experiencing VMS. Comprehensive searches were conducted in October 2024 across multiple databases, including MEDLINE/PubMed, Cochrane Library, and EMBASE, alongside manual backward and forward searches. Randomized controlled trials (RCTs) investigating physical activity or exercise interventions and their effects on subjective and objective sleep outcomes in women with VMS were included. The risk of bias was assessed using the revised Cochrane RoB 2 tool, and data were pooled for meta-analysis. Nine studies with a total of 1579 participants were analyzed. Physical activity interventions did not significantly improve sleep quality (-0.03 [-1.23, 1.18]; <em>P</em> = 0.96; I<sup>2</sup> = 78 %) or insomnia (−1.65 [−3.52, 0.21]; <em>P</em> = 0.08; I<sup>2</sup> = 0 %) but produced minor improvements in sleep problems (−0.08 [−0.16, −0.00]; <em>P</em> = 0.04; I<sup>2</sup> = 0 %). Despite concerns regarding bias, none of the studies were classified as high-risk, supporting result reliability. The findings suggest heterogeneity in the effects of physical activity on sleep, influenced by intervention-specific factors like type, frequency, intensity, timing, and duration. Environmental variables may also moderate these outcomes, highlighting the complexity of sleep regulation and the need for tailored approaches to improve sleep in menopausal women.</div><div>Review protocol is registered in PROSPERO: CRD42024599593</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108271"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The feasibility and effects of a telehealth-delivered physical therapy program for postmenopausal women with urinary incontinence: A pilot mixed-methods study 远程医疗提供的物理治疗方案对绝经后妇女尿失禁的可行性和效果:一项试点混合方法研究
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-23 DOI: 10.1016/j.maturitas.2025.108376
Kuan-Yin Lin , Chao-Yin Chen , Pei-Chi Wu , Min-Hsuan Huang , Yin-Chien Ou , Yao-Lin Kao , Kuan-Han Lin
{"title":"The feasibility and effects of a telehealth-delivered physical therapy program for postmenopausal women with urinary incontinence: A pilot mixed-methods study","authors":"Kuan-Yin Lin ,&nbsp;Chao-Yin Chen ,&nbsp;Pei-Chi Wu ,&nbsp;Min-Hsuan Huang ,&nbsp;Yin-Chien Ou ,&nbsp;Yao-Lin Kao ,&nbsp;Kuan-Han Lin","doi":"10.1016/j.maturitas.2025.108376","DOIUrl":"10.1016/j.maturitas.2025.108376","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the feasibility and effectiveness of a telehealth-delivered pelvic floor muscle training program for postmenopausal women with urinary incontinence, in comparison with face-to-face pelvic floor muscle training.</div></div><div><h3>Stud design</h3><div>This was a pilot mixed-methods study that included a non-inferiority randomized controlled trial with a nested qualitative study. Community-dwelling postmenopausal women (&gt;40 years) with urinary incontinence were recruited and randomly allocated to 12 weeks of telehealth or face-to-face pelvic floor muscle training. The face-to-face group received supervised training twice weekly, while the telehealth group had eight virtual sessions plus weekly telephone coaching.</div></div><div><h3>Main outcome measures</h3><div>Assessments at baseline, post-intervention, and three-month follow-up included feasibility, anthropometry, body composition, hand grip strength, functional exercise capacity, physical activity levels, the severity of urinary incontinence, and pelvic floor muscle function (assessed through vaginal manometry, transperineal ultrasound, and digital palpation).</div></div><div><h3>Results</h3><div>Among 55 potential participants, 22 enrolled (40 % consent rate). Attendance was 100 %, with 63.3 % adherence to the home program. Satisfaction was high (very satisfied: 71 % face-to-face, 89 % telehealth). Both groups reported increased confidence in pelvic floor muscle training. Urinary symptoms and pelvic floor function improved in both groups, with benefits sustained at three months. Telehealth pelvic floor muscle training also enhanced grip strength. No significant differences were found between groups.</div></div><div><h3>Conclusions</h3><div>Telehealth pelvic floor muscle training appears to be a feasible and potentially effective alternative to face-to-face therapy for postmenopausal women with urinary incontinence. Larger studies are needed to confirm these preliminary findings and guide future interventions.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (<span><span>NCT05970796</span><svg><path></path></svg></span>); date of registration: 29/07/2023.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108376"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in the use of menopausal hormone therapy in France, 2001–2023 2001-2023年法国绝经期激素治疗使用趋势
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-22 DOI: 10.1016/j.maturitas.2025.108270
Rafael Amaro Costa , Ana-Maria Vilcu , Manon Cairat , Eléa Olivier , Anne C.M. Thiébaut , Agnès Fournier
{"title":"Trends in the use of menopausal hormone therapy in France, 2001–2023","authors":"Rafael Amaro Costa ,&nbsp;Ana-Maria Vilcu ,&nbsp;Manon Cairat ,&nbsp;Eléa Olivier ,&nbsp;Anne C.M. Thiébaut ,&nbsp;Agnès Fournier","doi":"10.1016/j.maturitas.2025.108270","DOIUrl":"10.1016/j.maturitas.2025.108270","url":null,"abstract":"<div><h3>Objectives</h3><div>Few studies have examined trends in the use of menopausal hormone therapy (MHT) from the early 2010s onwards. Furthermore, data from the period after the release of the results of the Women's Health Initiative in 2002 are rarely reported with a distinction between systemic and local MHT. We therefore describe trends in the use of systemic and local MHT in France during the period 2001–2023.</div></div><div><h3>Study design</h3><div>Descriptive study using annual drug claim data aggregated at the national level from two French open-source databases.</div></div><div><h3>Main outcome measures</h3><div>The annual (2001-2023) number of estrogen-based MHT boxes reimbursed by the French National Health Insurance system was extracted and classified according to the route of administration. From 2014 onwards, data on the number of consumers of each estrogen-based MHT preparation, available by age categories, was used to further estimate the number of individuals using MHT, overall and by MHT type (systemic/local).</div></div><div><h3>Results</h3><div>The annual number of MHT claims fell from 25.0 to 6.3 million boxes between 2001 and 2023. Systemic MHT products almost exclusively accounted for this fall, while local MHT use remained rather stable. We estimated that, in 2023, local MHT was used by 1.1 million individuals (0.44 million aged 20–59 years and 0.67 aged 60+ years) and systemic MHT by 0.5 million (0.37 million aged 20–59 years and 0.16 million aged 60+ years).</div></div><div><h3>Conclusions</h3><div>In France, the use of systemic MHT has plummeted since 2001, while use of local MHT has remained stable. Claims for local MHT now represent more than half of all MHT claims in France.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108270"},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life at peri- and postmenopause: analysis of the results from app “Mi Menopausia” 绝经前后的生活质量:应用程序“Mi绝经”结果分析
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-19 DOI: 10.1016/j.maturitas.2025.108267
Pluvio J. Coronado , María Fasero , Nicolás Mendoza , Silvia P. González , Sonia Sánchez-Méndez , Jesús Presa , Ana R. Jurado , Esther de la Viuda , Francisco Quereda , on behalf of REIM (“Red Española de Investigación en Menopausia”)
{"title":"Quality of life at peri- and postmenopause: analysis of the results from app “Mi Menopausia”","authors":"Pluvio J. Coronado ,&nbsp;María Fasero ,&nbsp;Nicolás Mendoza ,&nbsp;Silvia P. González ,&nbsp;Sonia Sánchez-Méndez ,&nbsp;Jesús Presa ,&nbsp;Ana R. Jurado ,&nbsp;Esther de la Viuda ,&nbsp;Francisco Quereda ,&nbsp;on behalf of REIM (“Red Española de Investigación en Menopausia”)","doi":"10.1016/j.maturitas.2025.108267","DOIUrl":"10.1016/j.maturitas.2025.108267","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the health-related quality of life (HRQOL) of Spanish peri- and postmenopausal women using the Cervantes Short Form (SF) scale, and the factors associated with its variations.</div></div><div><h3>Study design</h3><div>A total of 7103 peri- and postmenopausal women were registered with the app “Mi Menopausia” from June 2021 to June 2024. This app is designed specifically for peri- and postmenopausal women. It measures HRQOL using the Cervantes SF scale (higher scores indicate lower HRQOL). Data collected included demographic information, lifestyle details, menopause symptoms, treatments for symptom relief, and personal medical history.</div></div><div><h3>Results</h3><div>Of the 6833 women included in the final analysis, 47.9 % were peri- and 52.1 % postmenopausal. The overall Cervantes SF score was 40.1 ± 16.8 and was associated in multivariant analysis with age (B: −0.29, 95 % confidence interval (CI): −0.36 to −0.21), obesity (B: 1.68; 95CI: 0.44 to 2.93), postmenopausal status (B: 1.11; 95CI: 0.22 to 2.0), education level (B: -1.05; 95CI: −1.91 to −0.19), having a partner (B: -2.76; 95CI: −4.03 to −1.49), sexual intercourse (B: -8.25; 95CI: −9.81 to −6.69), no sexual activity (B: 5.86; 95CI: 3.91 to 7.81), diagnosis of depression (B: 8.34; 95CI: 7.34 to 9.35), having undergone hysterectomy (B: 0.51; 95CI: 0.10 to 3.64) and oophorectomy (B: 0.90; 95CI: 0.10 to 3.64) and having experienced bone fractures (B: 0.71; 95CI: 0.12 to 2.90).</div></div><div><h3>Conclusion</h3><div>The HRQOL of peri- and postmenopausal Spanish women is complex but improvable and is associated with various factors, particularly related to sexual activity and a diagnosis of depression or anxiety.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108267"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis as a risk factor for age-related macular degeneration: A nationwide population-based study and genetic aspects 子宫内膜异位症是年龄相关性黄斑变性的危险因素:一项基于全国人群的研究和遗传方面
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-17 DOI: 10.1016/j.maturitas.2025.108272
Maria I. Zervou , Basil C. Tarlatzis , George N. Goulielmos
{"title":"Endometriosis as a risk factor for age-related macular degeneration: A nationwide population-based study and genetic aspects","authors":"Maria I. Zervou ,&nbsp;Basil C. Tarlatzis ,&nbsp;George N. Goulielmos","doi":"10.1016/j.maturitas.2025.108272","DOIUrl":"10.1016/j.maturitas.2025.108272","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108272"},"PeriodicalIF":3.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A smartphone model for post-acute care decreases all-cause mortality with improved left ventricular ejection fraction in patients hospitalized with heart failure in Taiwan 智能手机急性后护理模型降低全因死亡率与改善左心室射血分数住院心力衰竭患者在台湾
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-15 DOI: 10.1016/j.maturitas.2025.108269
Shuo-Chun Weng , Wei-Wen Lin , Jin-Long Huang , Chin-Yi Chao , Chiann-Yi Hsu , Shih-Yi Lin
{"title":"A smartphone model for post-acute care decreases all-cause mortality with improved left ventricular ejection fraction in patients hospitalized with heart failure in Taiwan","authors":"Shuo-Chun Weng ,&nbsp;Wei-Wen Lin ,&nbsp;Jin-Long Huang ,&nbsp;Chin-Yi Chao ,&nbsp;Chiann-Yi Hsu ,&nbsp;Shih-Yi Lin","doi":"10.1016/j.maturitas.2025.108269","DOIUrl":"10.1016/j.maturitas.2025.108269","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the impact of the use of a smartphone application on outcomes for patients with heart failure receiving post-acute care.</div></div><div><h3>Methods</h3><div>We employed a propensity score-matched analysis of patients who underwent post-acute care following hospitalization for heart failure. The smartphone application consisted of immediate feedback, recommendations, and a knowledge platform. We assessed seven variables before and after post-acute care: left ventricular ejection fraction, and scores on the Minnesota Living with Heart Failure Questionnaire, Mini-Nutritional Assessment–Short Form, Instrumental Activities of Daily Living, Brief Symptom Rating Scale-5, 6-minute walk test, and European Quality of Life-5 Dimensions Questionnaire. The functional progression dose effect was evaluated using receiver operating characteristic curves. Application users and non-users were matched to minimize the impacts of confounding variables, including age, gender, and education. The Cox proportional hazards model and the sub-distribution hazard method assessed the impact of the smartphone application on post-discharge outcomes.</div></div><div><h3>Results</h3><div>From 2018 to 2023, 493 patients (average age 65.4 ± 15.1 years) participated in the study. Over an average follow-up of 2.35 years, the results indicated that each additional unit of functional improvement was associated with a 38 % reduction in overall mortality, a 23 % decrease in readmissions or emergency room visits, and a 36 % lower risk of cardiovascular mortality. Among 119 matched pairs, application users demonstrated significantly lower mortality risk and better left ventricular ejection fraction than non-users. Kaplan-Meier curves showed that application users with improved left ventricular ejection fraction had the best survival outcomes, followed by non-application users with improved left ventricular ejection fraction, application users without improved left ventricular ejection fraction, and non-application users without improved left ventricular ejection fraction (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The findings suggest that smartphone applications could enhance transitional care for patients with heart failure by improving left ventricular ejection fraction and reducing mortality.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108269"},"PeriodicalIF":3.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyaluronic acid injection to treat symptoms of vulvovaginal atrophy in postmenopausal women: A 12-week randomised, placebo-controlled, multicentric study 透明质酸注射治疗绝经后妇女外阴阴道萎缩症状:一项为期12周的随机、安慰剂对照、多中心研究
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-12 DOI: 10.1016/j.maturitas.2025.108264
Fabienne Marchand Lamiraud , Hichem Bensmail , Carine Martin , Sofie Pelckmans , Firas Cha'ban , Aliette Siboni Frisch , Gulcan Deniz , Pascale Sabban Serfati , Brigitte Caubo , Brice Gurriet , Isabelle Petit Breuilh , Ann Inge Pastijn , Nicolas Berreni , Michel Cosson
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引用次数: 0
Xerostomia and oral health-related quality of life in peri- and postmenopausal women 围绝经期和绝经后妇女口干和口腔健康相关生活质量
IF 3.9 2区 医学
Maturitas Pub Date : 2025-04-11 DOI: 10.1016/j.maturitas.2025.108268
Pascual García-Alfaro , Faustino R. Pérez-López , Sandra García Martínez , Ignacio Rodríguez
{"title":"Xerostomia and oral health-related quality of life in peri- and postmenopausal women","authors":"Pascual García-Alfaro ,&nbsp;Faustino R. Pérez-López ,&nbsp;Sandra García Martínez ,&nbsp;Ignacio Rodríguez","doi":"10.1016/j.maturitas.2025.108268","DOIUrl":"10.1016/j.maturitas.2025.108268","url":null,"abstract":"<div><h3>Objective</h3><div>The menopausal transition triggers hormonal changes that can manifest in oral symptoms such as xerostomia, which can substantially impact women's quality of life. Our study examined the prevalence and severity of xerostomia and its association with menopausal status. Furthermore, we evaluated the impact of xerostomia on oral health-related quality of life in peri- and postmenopausal women.</div></div><div><h3>Methods</h3><div>This study was a cross-sectional investigation based on the results of a REDCap survey, involving 3211 women aged between 40 and 90 years. The survey recorded age, menopause status, age at menopause, smoking status, and being treated with xerogenic drugs and included two instruments: the Xerostomia Inventory, used to evaluate the oral symptoms; and the Oral Health Impact Profile-14 (OHIP-14), used to assess the related quality of life. Student's <em>t</em>-test, the chi-squared test, Pearson's correlation coefficient, and multivariable logistic and linear regressions were performed for data analysis. Odds ratio (OR), beta coefficient (β), and their 95 % confidence intervals (CIs) were applied to assess associations.</div></div><div><h3>Results</h3><div>The global prevalence of xerostomia was 71.2 %. The Xerostomia Inventory score correlated with the OHIP-14 score (<em>r</em> = 0.686; <em>p</em> = 0.000). Smoking was significantly associated with the probability of xerostomia (OR = 1.36; 95 % CI = 1.02–1.82), as were the following OHIP-14 domains: functional limitation (OR = 1.43; 95 % CI = 1.30–1.50), physical pain (OR = 1.17; 95 % CI = 1.06–1.29), psychological discomfort (OR = 1.21; 95 % CI = 1.13–1.29), physical disability (OR = 1.11; 95 % CI = 1.02–1.20), psychological disability (OR = 1.18; 95 % CI = 1.09–1.29), and social disability (OR = 1.15; 95 % CI = 1.01–1.32). There were no significant differences in the probability of xerostomia according to the menopausal status. In women with xerostomia the OHIP-14 score was higher than in women without xerostomia (β = 5.50; 95 % CI = 4.69–6.31).</div></div><div><h3>Conclusions</h3><div>Peri- and postmenopausal women have a high prevalence of xerostomia. There were no differences in the probability of xerostomia between peri- and postmenopausal women. There was a strong association between xerostomia symptoms and poor oral health-related quality of life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108268"},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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