Maturitas最新文献

{"title":"Are older women with early-stage endometrial cancer undertreated and more likely to die from their cancer?","authors":"Jeremy Barben ,&nbsp;Ariane Mamguem Kamga ,&nbsp;Adrien Guilloteau ,&nbsp;Valerie Quipourt ,&nbsp;Leila Bengrine-Lefevre ,&nbsp;Tienhan Sandrine Dabakuyo-Yonli","doi":"10.1016/j.maturitas.2025.108741","DOIUrl":"10.1016/j.maturitas.2025.108741","url":null,"abstract":"<div><div>Endometrial cancer is the most common gynecological malignancy in developed countries, mainly affecting older women and raising concerns about potential under-treatment. This study aimed to describe treatment patterns and assess net survival in older women with early-stage endometrial cancer.</div></div><div><h3>Study design</h3><div>This French retrospective observational study used a gynecological cancer registry. Patients diagnosed with FIGO I-II endometrial cancer from 1998 to 2018 were included and stratified by age (a younger group, under 70 years, and an older group, aged 70 years or more). A multiple penalized splines model was used.</div></div><div><h3>Results</h3><div>A total of 828 patients were included: 448 women aged under 70 and 380 aged 70 or more. Older patients belonged to higher-risk groups as defined by ESGO-ESTRO-ESP 2021 criteria (<em>p</em> &lt; 0.001) and had a lower rate of low-grade endometrioid carcinoma (75.1 % vs. 85.7 %, <em>p</em> = 0.003). Treatment patterns did not differ by age; surgery plus adjuvant therapy remained the main treatment (69.7 % vs. 70.8 % in the older and younger groups, respectively, <em>p</em> = 0.87). 5-year net survival was 95.0 % (95 % CI: 92.6–97.6) for younger and 84.3 % (95 % CI: 78.8–90.3) for older women. The univariate hazard ratio for death in older vs. younger women was 2.38 (95 % CI: 1.19–4.74; <em>p</em> = 0.02). Multivariate analysis attenuated age's effect: hazard ratio 1.38 (95 % CI: 0.97–3.31; <em>p</em> = 0.06). Charlson Comorbidity Index and non-low-grade endometrioid histology predicted poorer survival. Diagnosis period was not associated with survival.</div></div><div><h3>Conclusion</h3><div>No significant difference in treatment was found according to age. Although age was associated with 5-year net survival in univariate analysis, this association was no longer observed after adjusting for diagnosis period, comorbidities, and histology.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108741"},"PeriodicalIF":3.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term health consequences of childhood adverse events: A narrative review","authors":"Panagiotis Anagnostis ,&nbsp;Sofia Goulopoulou ,&nbsp;Julia K. Bosdou ,&nbsp;Konstantinos Lallas ,&nbsp;Vasileios Kotsis","doi":"10.1016/j.maturitas.2025.108738","DOIUrl":"10.1016/j.maturitas.2025.108738","url":null,"abstract":"<div><div>“Adverse childhood events” or childhood adversity is a term often used to describe trauma and sources of stress during childhood or adolescence. Childhood adversity may negatively affect multiple aspects of an adult's life, such as cardiovascular disease, cancer, mental disorders, including substance abuse, as well as infertility and gynecological conditions, such as endometriosis, fibroids and polycystic ovarian syndrome. A negative psychosocial environment during childhood may increase the incidence of cardiovascular risk factors, such as dyslipidemia, diabetes, arterial hypertension and abdominal obesity, even from adolescence. This accelerates atherosclerotic processes and predisposes to higher cardiovascular morbidity and mortality even from early adulthood. The higher the number and severity of childhood adverse events, the higher is the risk of cardiovascular disease. Adverse childhood events may also be implicated in tumorigenesis, since they have been associated with an increased risk of cancer, either directly or indirectly, due to increased prevalence of causal factors and behaviors, such as smoking and obesity. This is also the case for infertility and mental disorders. Although the exact pathogenetic pathways have not been clarified, chronic stress during childhood and adolescence, which provides a state of low-grade systematic inflammation and dysregulation of the hypothalamus-pituitary-adrenal axis, may be a common basis for these comorbidities. In any case, there is an exigent need for strategies to promptly identify and treat these patients at risk of developing these long-term health problems associated with childhood adversity.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108738"},"PeriodicalIF":3.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diverse sleep characteristics on long-term skeletal muscle loss: A cohort study","authors":"Seok Woo Hong ,&nbsp;Kyung Jae Yoon ,&nbsp;Jeong-Hyun Kang","doi":"10.1016/j.maturitas.2025.108739","DOIUrl":"10.1016/j.maturitas.2025.108739","url":null,"abstract":"<div><h3>Objective</h3><div>Poor sleep may contribute to hormonal imbalance, increased adiposity, and disruption of energy metabolism. This study aimed to clarify the long-term impact of sleep characteristics on loss of skeletal muscle mass.</div></div><div><h3>Methods</h3><div>We analyzed data from 421,688 participants (220,902 males, 200786 females; mean age 39.1 ± 10.2 years) without a low skeletal muscle index at baseline. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Skeletal muscle mass was estimated using bioelectrical impedance analysis. Low skeletal muscle index was diagnosed by the Asian Working Group for Sarcopenia 2019 Consensus. Covariates included demographic characteristics, health behavior, and lifestyle-related factors, comorbidities, biochemical markers, and dietary intake. Multivariate Cox regression analyses were conducted to assess effects of sleep characteristics on incidence of low skeletal muscle index.</div></div><div><h3>Results</h3><div>Participants who developed low skeletal muscle index exhibited poorer general sleep quality. Notably, skeletal muscle index, body fat mass, visceral fat area, and body fat percentage all significantly differed with sleep quality. Biochemical assessment revealed significant variations in serum proteins, glucose metabolism markers, lipid profiles, kidney and liver function, and inflammatory markers with sleep quality. After adjusting for confounders, longer sleep latency and lower sleep efficiency remained significant contributors to low skeletal muscle index. Additionally, frequent use of sleep medication and severe sleep disturbances were significantly associated with low skeletal muscle index.</div></div><div><h3>Conclusion</h3><div>Poor sleep quality, particularly longer sleep latency, lower sleep efficiency, frequent use of sleep medication and severe sleep disturbance, significantly impacts maintenance of skeletal muscle mass.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108739"},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of female overactive bladder syndrome: Results from a large retrospective cohort spanning 15 years","authors":"Marianne Koch ,&nbsp;Hannah Sayahpour ,&nbsp;Greta Lisa Carlin ,&nbsp;Tim Dorittke ,&nbsp;Rosa Loimer ,&nbsp;Anika Dibon ,&nbsp;Wolfgang Umek ,&nbsp;Florian Heinzl ,&nbsp;Barbara Bodner-Adler","doi":"10.1016/j.maturitas.2025.108736","DOIUrl":"10.1016/j.maturitas.2025.108736","url":null,"abstract":"<div><h3>Objectives</h3><div>This study analyzed subgroups of women with overactive bladder syndrome or mixed urinary incontinence to assess treatment success, time to success, therapy adherence, and demographic and clinical characteristics.</div></div><div><h3>Study design</h3><div>This retrospective cohort study was conducted with 1688 female patients diagnosed with overactive bladder or mixed incontinence. Data on patient demographics, clinical characteristics, treatment modalities, and outcomes were analyzed using descriptive statistics and Kaplan-Meier survival analysis.</div></div><div><h3>Main outcome measures</h3><div>Treatment success levels were categorized into no success, partial success, and complete success. Time to success was assessed using Kaplan-Meier curves. Demographic and clinical characteristics influencing outcomes were evaluated.</div></div><div><h3>Results</h3><div>Patients with mixed incontinence were younger, had a higher body mass index (BMI), had more comorbidities, and had more severe symptoms than those with isolated overactive bladder. Patients with overactive bladder were more often postmenopausal and had better early treatment success. Most patients improved early, though some required long-term follow-up. Significant differences in treatment utilization and outcomes were observed between subgroups. Polypharmacy, obesity, nocturia, and a diagnosis of mixed incontinence were associated with lower rates of success. Local estrogen, subtype of overactive bladder, and fewer medications predicted better outcomes and earlier response.</div></div><div><h3>Conclusions</h3><div>Personalized treatment strategies tailored to patient demographics and treatment history are crucial in managing overactive bladder and mixed incontinence effectively. The findings underscore the importance of long-term adherence to therapy and highlight areas for refining therapeutic interventions to optimize patient outcomes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108736"},"PeriodicalIF":3.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of intrinsic capacity impairment and associated factors in older people living with HIV in China","authors":"Xiaojun Meng ,&nbsp;Bolin Yang ,&nbsp;Jibiao Chen ,&nbsp;Chenlu He ,&nbsp;Hanlu Yin ,&nbsp;Jing Gu ,&nbsp;Zhuping Xu ,&nbsp;Yayong Ji","doi":"10.1016/j.maturitas.2025.108732","DOIUrl":"10.1016/j.maturitas.2025.108732","url":null,"abstract":"<div><h3>Background</h3><div>Although intrinsic capacity (IC) has been evaluated among community-dwelling older people, IC among older people living with HIV (PLHIV) remains underexplored. This study investigated IC impairment and associated factors in older PLHIV in mainland China.</div></div><div><h3>Methods</h3><div>This cross-sectional study, conducted in China, enrolled older PLHIV aged ≥50 years. IC was assessed using detailed scales covering the domains of locomotion, vitality, cognition, psychology, and sensory capacity. Logistic regression analyses were used to explore the determinants of IC impairment in this population.</div></div><div><h3>Results</h3><div>Among 830 participants, 26.4 % (219/830) had impairment in at least one domain. A higher risk of IC impairment was associated with age ≥ 70 years (OR 2.44, 95 % CI 1.56–3.81), living with family members (OR 1.83, 95 % CI 1.24–2.69), being overweight or obese (OR 1.45, 95 % CI 1.03–2.04), impaired family function (OR 2.46, 95 % CI 1.65–3.66), and a high level of loneliness (OR 1.52, 95 % CI 1.04–2.24). In contrast, participants who were less likely to have IC impairment included those with an average monthly income ≥5000 RMB (OR 0.52, 95 % CI 0.32–0.86), those who exercised more than twice per week (OR 0.59, 95 % CI 0.42–0.82), and those with a baseline CD4⁺ T cell count ≥200 cells/μL (OR 0.70, 95 % CI 0.50–0.98).</div></div><div><h3>Conclusion</h3><div>It is evident that some PLHIV are experiencing impairments across various domains. Formulating policies to support early preventive interventions and to provide timely medical intervention when needed is essential for promoting healthy ageing among older PLHIV.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108732"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply to Hong Zhang et al","authors":"Haomin Wang ,&nbsp;Huamei Ju ,&nbsp;Shu Zhang ,&nbsp;Haojie Li ,&nbsp;Xia Chen","doi":"10.1016/j.maturitas.2025.108734","DOIUrl":"10.1016/j.maturitas.2025.108734","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108734"},"PeriodicalIF":3.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Wang et al., ‘impacts of fetal/infant and adolescent exposure to famine on age at menopause in Chinese women’: Methodological gaps in famine–menopause analyses (exposure and risks)","authors":"Hong Zhang ,&nbsp;Xiaohan Zhang ,&nbsp;Xiucai Song","doi":"10.1016/j.maturitas.2025.108733","DOIUrl":"10.1016/j.maturitas.2025.108733","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108733"},"PeriodicalIF":3.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on the paper “Menopause and risk of atherosclerotic cardiovascular disease: Insights from a women's UK Biobank cohort”","authors":"Weichu Sun","doi":"10.1016/j.maturitas.2025.108731","DOIUrl":"10.1016/j.maturitas.2025.108731","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108731"},"PeriodicalIF":3.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to Weichu Sun","authors":"Alexandre Vallée","doi":"10.1016/j.maturitas.2025.108730","DOIUrl":"10.1016/j.maturitas.2025.108730","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108730"},"PeriodicalIF":3.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The growing challenge of aging populations: Addressing health and societal impacts","authors":"Maria Karaflou ,&nbsp;Dimitrios G. Goulis","doi":"10.1016/j.maturitas.2025.108720","DOIUrl":"10.1016/j.maturitas.2025.108720","url":null,"abstract":"<div><div>Aging is a multifactorial process characterized by physiological damage, an increased risk of age-related diseases, and functional deterioration. Aging populations significantly strain social and healthcare resources. Greater understanding of the biology of aging is needed, but is challenging because of the variations in the progression, rate, and phenotype of aging across different organisms, organs, cell types, and molecules. This review discusses the use of new technologies, such as telemedicine, artificial intelligence, and robotics, to address the increased need for health and care services. Policy must focus on nutrition, physical activity, and improving the built and natural environments to promote public health.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108720"},"PeriodicalIF":3.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}