Maturitas最新文献

{"title":"Erratum to “Sex differences in the association between dynapenic abdominal obesity and onset of disability in activities of daily living among adults aged ≥50 years: A prospective analysis of the Irish Longitudinal Study on Ageing” [Maturitas 176C (2023) 107763]","authors":"Lee Smith , Guillermo F. López Sánchez , Mark A. Tully , Nicola Veronese , Pinar Soysal , Dong Keon Yon , Damiano Pizzol , José Francisco López-Gil , Yvonne Barnet , Laurie Butler , Jae Il Shin , Ai Koyanagi","doi":"10.1016/j.maturitas.2025.108667","DOIUrl":"10.1016/j.maturitas.2025.108667","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108667"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night shift work and anti-Müllerian hormone concentrations in a cohort of black women","authors":"Sarah C. Cromack ,&nbsp;Charley Jiang ,&nbsp;Lauren A. Wise ,&nbsp;Donna D. Baird ,&nbsp;Mercedes R. Carnethon ,&nbsp;Quaker E. Harmon ,&nbsp;Erica E. Marsh ,&nbsp;Lia A. Bernardi","doi":"10.1016/j.maturitas.2025.108666","DOIUrl":"10.1016/j.maturitas.2025.108666","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate if current night shift work is associated with anti-Müllerian hormone (AMH) concentrations.</div></div><div><h3>Study design</h3><div>We analyzed baseline data from participants in the Study of the Environment, Lifestyle, and Fibroids (SELF), a prospective cohort study of Black women recruited 2010–2012 in metropolitan Detroit, MI. Our cohort comprised 1641 participants with serum AMH determined at baseline. AMH concentrations were used to measure ovarian reserve, i.e. the quantity of oocytes remaining in the ovary. On self-administered baseline questionnaires, participants reported whether they currently worked night shifts and, if so, how frequently. We used multivariable linear regression models to estimate percent differences and 95 % confidence intervals (CI) in mean AMH concentrations across categories of current night shift work (non-current, &lt;1/month, ≥1/month), adjusting for covariates known to be associated with AMH concentrations (e.g., demographic factors such as age, abnormal bleeding, and contraceptive use) and baseline sleep characteristics (sleep duration, satisfaction, and efficiency).</div></div><div><h3>Main outcome measure</h3><div>Mean anti-Müllerian hormone concentrations.</div></div><div><h3>Results</h3><div>Mean AMH concentrations were similar in the group of frequent night shift workers (<em>n</em> = 196, 12 %) and the group of infrequent/non-current night shift workers (<em>n</em> = 1445, 88 %): 4.78 ± 4.15 ng/mL vs. 5.14 ± 4.20 ng/mL. Results were similar after adjusting for potential confounders, with only a small percent difference in AMH concentrations of −8.1 % observed between the two groups (95 % CI -19.8 %, 5.4 %).</div></div><div><h3>Conclusions</h3><div>Frequent night shift work was not appreciably associated with AMH concentrations in this large cohort of reproductive-aged Black women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108666"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical clusters of obesity in France related to complex longitudinal socio-behavioral profiles: findings from the GAZEL cohort","authors":"Stéphane Joost ,&nbsp;Noé Fellay ,&nbsp;Philippe Voruz ,&nbsp;Anaïs Ladoy ,&nbsp;Gabriel Kathari ,&nbsp;Raphael Renevey ,&nbsp;Marcel Goldberg ,&nbsp;Marie Zins ,&nbsp;Joane Matta ,&nbsp;Sébastien Czernichow","doi":"10.1016/j.maturitas.2025.108665","DOIUrl":"10.1016/j.maturitas.2025.108665","url":null,"abstract":"<div><h3>Background/objectives</h3><div>This study analyzed the temporal evolution of geographic clusters of obesity among employees of the French national gas and electricity company in the GAZEL cohort from 1990 to 2015.</div></div><div><h3>Subjects/methods</h3><div>The study included 12,798 men and 4590 women (aged 40 to 72 years) followed since 1989. Spatiotemporal clusters of obesity were identified using SaTScan software, and spatial dependence was assessed with the spatial relative risk function in the SPARR package. General estimating equations accounted for correlated observations in clustered or repeated measures data.</div></div><div><h3>Results</h3><div>SaTScan identified significant obesity clusters primarily in northern France, persisting throughout the study period. In 1990, 35.8 % of participants were in obesity hotspots, peaking at 36.8 % in 1995, then declining to 21.4 % in 2015, as confirmed by spatial relative risk analysis. Despite a stable adjusted mean body mass index, the prevalence of obesity increased, indicating more individuals crossing into obesity. Models showed alcohol and tobacco use were significantly associated with body mass index and spatial clustering, with longitudinal interactions influenced by sex and age.</div></div><div><h3>Conclusions</h3><div>Although adjusted mean body mass index remained stable from 1990 to 2015, obesity prevalence increased, with persistent clusters in northern France and Paris. The dilution of clusters over time may be influenced by aging and retirement-induced relocations. These findings underscore the importance of monitoring spatial and temporal obesity trends within populations to address the growing obesity problem effectively.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108665"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopically confirmed endometriosis and midlife plasma markers of inflammation, cholesterol, and adipokines among participants in the Nurses' Health Study II","authors":"Leslie V. Farland ,&nbsp;William J. Degnan III ,&nbsp;Holly R. Harris ,&nbsp;Naoko Sasamoto ,&nbsp;Kathryn M. Rexrode ,&nbsp;Stacey A. Missmer","doi":"10.1016/j.maturitas.2025.108663","DOIUrl":"10.1016/j.maturitas.2025.108663","url":null,"abstract":"<div><h3>Objective</h3><div>Endometriosis may increase the risk of cardiovascular disease, possibly through a detrimental impact on circulating biomarkers. However, there is a paucity of research on endometriosis and inflammation, lipids, and adipokines at midlife.</div></div><div><h3>Methods</h3><div>We used generalized linear models to determine the association between laparoscopically confirmed endometriosis and log-transformed levels of plasma C-reactive protein (<em>n</em> = 3936), interleukin-6 (<em>n</em> = 3495), tumor necrosis factor-alpha receptor 2 (<em>n</em> = 2967), high-density lipoprotein cholesterol (<em>n</em> = 1533), low-density lipoprotein cholesterol (<em>n</em> = 1324), total cholesterol (<em>n</em> = 4898), leptin (<em>n</em> = 2480), and adiponectin (<em>n</em> = 4262) among participants with existing biomarker measurements in the Nurses' Health Study II (average age 44 years). We investigated heterogeneity by body mass index (&lt;25 kg/m² vs. ≥ 25 kg/m²).</div></div><div><h3>Results</h3><div>We did not observe associations between endometriosis and midlife inflammatory biomarkers (C-reactive protein % difference: -4.6, 95 % CI [−15.7,7.9]; interleukin-6: −0.4 % [−7.2,7.1]; tumor necrosis factor-alpha receptor 2: −1.3 % [−4.1,1.6]) or levels of high-density lipoprotein cholesterol (0.8 % [−3.7,5.6]), low-density lipoprotein cholesterol (−0.2 % [−5.2,5.1]), total cholesterol (1.0 % [−0.7,2.7]), or adiponectin (−4.0 [−8.8,1.0]). Women with endometriosis had higher leptin levels (9.0 % [0.5, 18.1]). Associations varied by body mass index for total cholesterol (<em>p</em>-value 0.05) and leptin (p-value 0.02). Among women with a body mass index ≥25 kg/m², those with endometriosis had a mean total cholesterol level that was 2.7 % higher (0.2,5.2) than among those without; among those with a body mass index &lt;25 kg/m², those with endometriosis had a mean leptin level that was 15.7 % higher (4.6, 28.1) than among those without endometriosis.</div></div><div><h3>Conclusions</h3><div>Endometriosis was not associated with midlife systemic inflammation, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or adiponectin. Endometriosis was associated with higher leptin among those with a body mass index &lt;25 kg/m² and higher total cholesterol among those with a body mass index ≥25 kg/m². These findings suggest that endometriosis may influence cardiovascular disease risk via midlife cholesterol and leptin.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108663"},"PeriodicalIF":3.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic health among socioeconomically vulnerable adults in Greece during the economic crisis: The cross-sectional primary healthcare EGKARDIA study","authors":"Dionysios Palermos ,&nbsp;Theodoros N. Sergentanis ,&nbsp;Elpida Pavi ,&nbsp;Evangelia Athanasiadou ,&nbsp;Maria Kantzanou ,&nbsp;Theodora Psaltopoulou","doi":"10.1016/j.maturitas.2025.108654","DOIUrl":"10.1016/j.maturitas.2025.108654","url":null,"abstract":"<div><h3>Objective</h3><div>The EGKARDIA study screened socioeconomically vulnerable populations for cardiometabolic diseases during the Greek economic crisis and assessed its impact on their health.</div></div><div><h3>Study design</h3><div>EGKARDIA was a cross-sectional primary healthcare study conducted between 2013 and 2015 at health centers in the metropolitan region of Athens, Greece. The study included individuals aged 30 and above recruited from Open Care Centers for the Elderly, social and municipal clinics, and those voluntarily seeking screening.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was the prevalence of cardiometabolic diseases (hypertension, obesity, dyslipidemia, diabetes mellitus); factors associated with hypertension were also studied (sociodemographic and lifestyle data, dietary and physical activity patterns, mental health and health-related quality of life, self-perception of being affected by the economic crisis).</div></div><div><h3>Results</h3><div>Among 5609 participants (65 % female at birth, 31 % aged 65 years or more, 39 % with only compulsory education, and 24 % unemployed), 89 % were physically inactive or minimally active, 56 % were ever-smokers, 27 % were obese, 55 % had hypertension (28 % undiagnosed), 84 % had dyslipidemia (49 % undiagnosed), and 15 % had diabetes mellitus (9 % undiagnosed). Additionally, 20 % showed moderate or severe depression. Hypertension was independently associated with male sex at birth, older age, low education, physical inactivity, retirement, unemployment, depression, overweight and obesity, diabetes mellitus and dyslipidemia. A similar set of associations was noted regarding undiagnosed hypertension.</div></div><div><h3>Conclusions</h3><div>The EGKARDIA study revealed a particularly high prevalence of cardiometabolic diseases among socioeconomically vulnerable individuals, emphasizing the need for targeted public health interventions to support those populations.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108654"},"PeriodicalIF":3.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing sexual problems: General practitioners' practice patterns","authors":"Sanna-Mari Manninen ,&nbsp;Katja Kero ,&nbsp;Tero Vahlberg ,&nbsp;Päivi Polo-Kantola","doi":"10.1016/j.maturitas.2025.108655","DOIUrl":"10.1016/j.maturitas.2025.108655","url":null,"abstract":"<div><h3>Objectives</h3><div>Although sexual problems are common, they are rarely inquired about or treated in appointments with general practitioners (GPs). This study aimed to evaluate GPs' attitudes and practice patterns in addressing patients' sexual problems.</div></div><div><h3>Study design</h3><div>A cross-sectional, quantitative, web-based questionnaire survey was conducted among a random sample of 1000 GPs in Finland.</div></div><div><h3>Main outcome measures</h3><div>The study covered three focus areas: (1) GPs' attitudes toward the management of sexual problems, (2) frequency of GPs' inquiries to patients about various sexual problems, and (3) GPs' practice patterns in the treatment of sexual problems.</div></div><div><h3>Results</h3><div>Altogether, 402 GPs (aged 27–65 years, 75 % female and 25 % male) responded. Diagnosing sexual problems in both male and female patients was considered difficult, but especially so in female patients. The GPs asked their patients with sexual problems most often about erectile dysfunction (87.3 %), decreased libido (70.4 %), and dyspareunia (66.4 %). When diagnosing sexual problems, 52.2 % prescribed medications, 35.3 % ordered treatments other than medications, 26.4 % ordered further tests, 19.4 % referred patients to a sexual medicine specialist, and only 6 % reported that their organization had guidelines on where to refer patients with sexual problems for continued care.</div></div><div><h3>Conclusions</h3><div>Increasing GP education in sexual medicine is essential to enhance their knowledge of sexual health and improve their recognition of sexual health problems during patient consultations. Clinical practice guidelines regarding the treatment of sexual problems are also needed to systematize GPs' practice patterns regarding patients' sexual problems in order to prevent underdiagnosis and undertreatment of such problems.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108655"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in nutrition and ageing research – A primer on the benefits","authors":"Pol Grootswagers ,&nbsp;Tijl Grootswagers","doi":"10.1016/j.maturitas.2025.108662","DOIUrl":"10.1016/j.maturitas.2025.108662","url":null,"abstract":"<div><div>Artificial intelligence (AI) is increasingly impacting multiple domains. The application of AI in nutrition and ageing research has significant potential to transform healthcare outcomes for the ageing population. This review provides critical insights into how AI techniques—such as machine learning, natural language processing, and deep learning—are used in the context of care for older people to predict health outcomes, identify risk factors, and enhance dietary assessments. Trained on large datasets, AI models have demonstrated high accuracy in diagnosing malnutrition, predicting bone mineral density abnormalities, and forecasting risks of chronic diseases, thereby addressing significant gaps in early detection and intervention strategies.</div><div>In addition, we review novel applications of AI in automating dietary intake assessments through image recognition and analysing eating behaviours; these offer innovative tools for personalised nutrition interventions. The review also discusses and showcases the integration of AI in research logistics, such as AI-assisted literature screening and data synthesis, which can accelerate scientific discovery in this domain.</div><div>Despite these promising advancements, there are critical challenges hindering the widespread adoption of AI, including issues around data quality, ethical considerations, and the interpretability of AI models. By addressing these barriers, the review underscores the necessity for interdisciplinary collaboration to best harness AI's potential.</div><div>Our goal is for this review to serve as a guide for researchers and practitioners aiming to understand and leverage AI technologies in nutrition and healthy ageing. By bridging the gap between AI's promise and its practical applications, this review directs future innovations that could positively affect the health and well-being of the ageing population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108662"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoflavones and changes in body weight and severe hot flashes in postmenopausal women: A secondary analysis of a randomized clinical trial","authors":"Hana Kahleova ,&nbsp;Tatiana Znayenko-Miller ,&nbsp;Richard Holubkov ,&nbsp;Neal D. Barnard","doi":"10.1016/j.maturitas.2025.108661","DOIUrl":"10.1016/j.maturitas.2025.108661","url":null,"abstract":"<div><h3>Objective</h3><div>Severe hot flashes have been associated with an increased risk of cardiovascular disease and diabetes. This secondary analysis assessed associations between isoflavone intake, body weight, and severe hot flashes in postmenopausal women.</div></div><div><h3>Methods</h3><div>Participants (n = 84) were randomly assigned to a low-fat vegan diet supplemented with soybeans (n = 42) or a control group who made no changes to their diet (n = 42) for 12 weeks. Three-day diet records were analyzed using the Nutrition Data System for Research software. A repeated measures analysis of variance, Spearman correlations, and a linear regression model were used for statistical analyses.</div></div><div><h3>Results</h3><div>Daidzein intake increased in the vegan group (effect size: +34.4 mg/day [95 % CI +28.1 to +40.8], p &lt; 0.001). Similarly, genistein and glycitein increased in the vegan group (effect sizes: +34.8 mg/day [95 % CI +27.7 to +42.0], p &lt; 0.001; and +4.2 mg/day [95 % CI +3.2 to +5.2], p &lt; 0.001, respectively). Mean body weight decreased by 3.6 kg in the vegan group and by 0.2 kg in the control group (effect size: −3.4 kg [95 % CI −4.5 to −2.3], p &lt; 0.001). Severe hot flashes were reduced by 92 % (from 1.3/day to 0.1/day) in the vegan group (p &lt; 0.001) and did not change significantly in the control group (between-group p = 0.02). The increased consumption of each of the three isoflavones was associated with weight loss (r = −0.67, p &lt; 0.001 for daidzein; r = −0.67, p &lt; 0.001 for genistein; and r = −0.66, p &lt; 0.001 for glycitein), but not with the reduction in severe hot flashes. There was no significant association between weight loss and a reduction in severe hot flashes (r = +0.20, p = 0.12). Controlling for energy intake and changes in body mass index, the main independent predictor of a reduction in severe hot flashes was the increased intake of daidzein (p = 0.04). Controlling for fiber and fat intake did not change the results.</div></div><div><h3>Conclusions</h3><div>These findings suggest that the mechanisms by which a low-fat vegan diet supplemented with soybeans reduces the frequency of severe hot flashes include the increased consumption of daidzein, among other potential factors. Confirmatory trials are needed.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, <span><span>NCT04587154</span><svg><path></path></svg></span>, registered on Oct 14, 2020.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108661"},"PeriodicalIF":3.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal stage transitions and associations with overall and domain-specific perceived stress in middle-aged Korean women","authors":"Yoonyoung Jang ,&nbsp;Yoosoo Chang ,&nbsp;Sang Won Jeon ,&nbsp;Junhee Park ,&nbsp;Byungtae Seo ,&nbsp;Jeonggyu Kang ,&nbsp;Ria Kwon ,&nbsp;Ga-young Lim ,&nbsp;Kye-Hyun Kim ,&nbsp;Hoon Kim ,&nbsp;Yun Soo Hong ,&nbsp;Jihwan Park ,&nbsp;Di Zhao ,&nbsp;Juhee Cho ,&nbsp;Eliseo Guallar ,&nbsp;Seungho Ryu","doi":"10.1016/j.maturitas.2025.108660","DOIUrl":"10.1016/j.maturitas.2025.108660","url":null,"abstract":"<div><h3>Background</h3><div>The menopausal transition, closely linked to later-life health, involves substantial physiological and psychological changes, potentially increasing perceived stress. However, longitudinal studies have reported inconsistent results, with limited data for Asian women, despite the potential for perceived stress to vary with both race and socioeconomic status. Therefore, this study investigated the longitudinal association between menopausal transition and perceived stress among middle-aged Korean women.</div></div><div><h3>Materials and methods</h3><div>We conducted a longitudinal study on 4619 women aged 42–52 who provided written consent in person at the Kangbuk Samsung Hospital Total Healthcare Center between 2014 and 2018. Participants were followed until August 2023, with a median follow-up of 6.6 years (interquartile range: 5.1–7.7), with 2 to 8 repeated comprehensive health screenings. We examined associations between menopausal transition and total scores and domain sub-scores (anger, tension, and depression) on the Perceived Stress Inventory using a linear mixed-effects model.</div></div><div><h3>Results</h3><div>Overall Perceived Stress Inventory and anger scores significantly increased during the late transition stage compared with the pre-menopause stage; however, they decreased during post-menopause. Tension scores showed a similar trend, although the results were not significant. Depression scores significantly increased during the early transition, late transition, and post-menopause stages compared with the pre-menopause stage.</div></div><div><h3>Conclusion</h3><div>Middle-aged Korean women's perceived stress significantly increased during the menopausal transition independent of age, marital status, education, and other confounders. Further research is needed to explore the implications of heightened stress and to assess the potential benefits of targeted interventions for women's health during this period.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108660"},"PeriodicalIF":3.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral capsules of Rosa damascena mill extract on depression, anxiety and stress in menopausal women: A randomized controlled trial","authors":"Zohreh Gholinezhad,&nbsp;Fatemeh Zahra Karimi,&nbsp;Hassan Rakhshandeh,&nbsp;Seyed Reza Mazloum","doi":"10.1016/j.maturitas.2025.108659","DOIUrl":"10.1016/j.maturitas.2025.108659","url":null,"abstract":"<div><h3>Objective</h3><div>Depression, anxiety, and stress often increase during menopause. Due to growing interest in herbal alternative medicines with fewer side-effects, this study aimed to assess the effect of Rosa damascena Mill extract on depression, anxiety, and stress in menopausal women.</div></div><div><h3>Methods</h3><div>This triple-blind randomized controlled trial included 82 naturally menopausal women between 45 and 60 years of age, who had not menstruated for at least 12 consecutive months and had no history of serious medical conditions such as malignancy. Participants were randomly assigned to receive either 500 mg Rosa damascena extract or placebo capsules twice daily for eight weeks. Psychological symptoms were evaluated using the Depression, Anxiety, and Stress Scale - 21 at baseline, 4, and 8 weeks after the intervention. The data were statistically analyzed using SPSS version 21.</div></div><div><h3>Results</h3><div>The intervention group demonstrated a statistically significant reduction in depression scores (from 10.1 ± 10.7 to 3.9 ± 4.6) whereas the placebo group showed a slight increase (from 8.7 ± 8.3 to 9.6 ± 7.5) (<em>p</em> &lt; 0.001). Anxiety scores also declined more markedly in the intervention group (from 14.6 ± 8.3 to 6.2 ± 4.8) than in the placebo group (from 12.9 ± 7.8 to 12.2 ± 7.8) (<em>p</em> &lt; 0.001). Stress levels decreased in the intervention group (from 19.0 ± 9.3 to 7.6 ± 4.6), while the placebo group showed a slight increase (15.9 ± 10.0 to 17.6 ± 9.0) (<em>p</em> &lt; 0.001). Post-hoc analysis using Bonferroni correction revealed significant differences across all time points in the intervention group (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Rosa damascena extract may serve as an effective and well-tolerated herbal intervention for mitigating depression, anxiety, and stress among menopausal women.</div></div><div><h3>Trial registration</h3><div>IRCT20210208050295N1</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108659"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}