Maturitas最新文献

{"title":"Association between leg-to-trunk lean mass ratio measured by dual-energy X-ray absorptiometry and later falls in older Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study","authors":"Akihiro Takada ,&nbsp;Katsuyasu Kouda ,&nbsp;Yuki Fujita ,&nbsp;Kumiko Ohara ,&nbsp;Takahiro Tachiki ,&nbsp;Junko Tamaki ,&nbsp;Jong-Seong Moon ,&nbsp;Etsuko Kajita ,&nbsp;Jun Kitagawa ,&nbsp;Nozomi Okamoto ,&nbsp;Masayuki Iki","doi":"10.1016/j.maturitas.2025.108596","DOIUrl":"10.1016/j.maturitas.2025.108596","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia, defined as “decreased lean mass (LM) plus low muscle strength and/or low physical performance,” is associated with a high risk of falls and fractures. Although an association between muscle strength and falls has been reported, the association between LM and falls remains unclear, with previous studies reporting conflicting findings. We investigated the association of LM measured precisely by dual-energy X-ray absorptiometry with later falls in community-dwelling Japanese men aged 65 years or more at the time of the baseline survey.</div></div><div><h3>Methods</h3><div>The present analyses included 507 older men who provided complete information on LM and falls in the Fujiwara-kyo Osteoporosis Risk in Men cohort study. Whole-body LM and regional LM were measured from 2017 to 2019. LM in each body region, including the legs and trunk, was recorded. The leg-to-trunk LM ratio, calculated as leg LM divided by trunk LM, was also analyzed. Information on falls that occurred in the 12 months prior to the 2022–2023 follow-up survey was obtained.</div></div><div><h3>Results</h3><div>Mean trunk LM was significantly larger, and mean leg-to-trunk LM ratio significantly smaller, in fallers than in non-fallers (P &lt; 0.05). Multiple logistic regression analysis revealed that leg-to-trunk LM ratio was significantly inversely associated with falls after adjusting for potential confounders (P &lt; 0.05), whereas no significant associations were observed between whole-body and regional LM and falls.</div></div><div><h3>Conclusion</h3><div>Leg-to-trunk LM ratio was associated with later falls in community-dwelling older Japanese men. Older men with a larger distribution of leg LM relative to trunk LM tended to have a lower risk of later falls.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108596"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause is associated with a reduction in glomerular filtration rate, independent of body composition and metabolic syndrome","authors":"Alessandro Leone ,&nbsp;Francesca Menichetti ,&nbsp;Federica Sileo ,&nbsp;Silvia Gallosti ,&nbsp;Ramona De Amicis ,&nbsp;Andrea Foppiani ,&nbsp;Simona Bertoli ,&nbsp;Alberto Battezzati","doi":"10.1016/j.maturitas.2025.108595","DOIUrl":"10.1016/j.maturitas.2025.108595","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the relationship between menopause and glomerular filtration rate (GFR), independent of body composition and metabolic profile, both known risk factors for GFR decline.</div></div><div><h3>Study design</h3><div>Cross-sectional study involving 3918 women aged 40–55 years.</div></div><div><h3>Main outcome measures</h3><div>Participants provided information about medical history, menopausal status, and current medication use. Participants underwent nutritional and anthropometric assessments. Blood samples were collected to measure biochemical parameters. Menopause was defined as no menstrual cycle for 12 months or more. GFR was estimated using the EPI-CKD formula, and metabolic syndrome was identified using harmonized criteria. Premenopausal and postmenopausal women were matched by age, body composition, and metabolic syndrome factors to assess the menopause–GFR association.</div></div><div><h3>Results</h3><div>Postmenopausal women exhibited higher fat mass, lower fat-free mass, and reduced GFR compared with premenopausal women. They also had higher rates of hypertension, impaired fasting glucose, and metabolic syndrome. After matching for age, fat mass index, fat-free mass index, and components of the metabolic syndrome, menopause was independently associated with a GFR reduction of 2.32 ml/min/1.73m² (95 % CI: −3.81, −0.83). Additionally, menopause was linked to a 51 % higher risk of GFR &lt;90 ml/min/1.73m² (OR = 1.51; 95 % CI 1.12, 2.02).</div></div><div><h3>Conclusions</h3><div>Menopause represents an independent risk factor for GFR decline, beyond the effects related to body composition and metabolic risk factors.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108595"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning models to predict decline in intrinsic capacity among older adults in China: a prospective cohort study","authors":"Runjie Sun,&nbsp;Yijing Li,&nbsp;Yanru Kang,&nbsp;Xinqi Xu,&nbsp;Jie Zhu,&nbsp;Haiyan Fu,&nbsp;Yining Zhang,&nbsp;Jingwen Lin,&nbsp;Yongbing Liu","doi":"10.1016/j.maturitas.2025.108594","DOIUrl":"10.1016/j.maturitas.2025.108594","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring intrinsic capacity and implementing appropriate interventions can support healthy aging. There are, though, few tools available for predicting decline in intrinsic capacity among older adults. This study aimed to develop and validate an interpretable machine learning model designed to identify populations at elevated risk of a decline in intrinsic capacity.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study baseline (2011) and 4-year follow-up (2015), a total of 822 participants were randomly allocated to a training set and a testing set at a 7:3 ratio. Five machine learning methods were employed to train the model and assess its performance through various metrics. The SHapley Additive exPlanation method was subsequently used to interpret the optimal model.</div></div><div><h3>Results</h3><div>The 4-year incidence of decline in intrinsic capacity among the older adults in the sample was 44.6 % (<em>n</em> = 367). Nine variables were screened for model construction, among which eXtreme gradient boosting demonstrated the best predictive performance, achieving an area under the receiver operating characteristic curve (AUC) of 0.715 (95 % CI 0.651–0.780) in the testing set. The SHapley Additive exPlanation method identified educational level, smoking, handgrip strength, self-rated health, and residence as the top five significant predictors.</div></div><div><h3>Conclusions</h3><div>The developed model can serve as a highly effective tool for primary care teams to identify older adults with early signs of decline in intrinsic capacity, facilitating the provision of subsequent screening and tailored interventions for intrinsic capacity.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108594"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause and hair loss in women: Exploring the hormonal transition","authors":"Aditya K. Gupta ,&nbsp;Vasiliki Economopoulos ,&nbsp;Avantika Mann ,&nbsp;Tong Wang ,&nbsp;Paradi Mirmirani","doi":"10.1016/j.maturitas.2025.108378","DOIUrl":"10.1016/j.maturitas.2025.108378","url":null,"abstract":"<div><div>Menopause, which is defined as the cessation of menstruation, may be preceded by hormonal fluctuations during the transition to menopause, up to 10 years prior. During this time, hormonal changes, including the relative increase in androgens and the cessation of ovarian estrogen production directly impacts the hair follicle, which is an estrogen-sensitive tissue. These hormonal fluctuations can lead to alterations in the hair shaft and hair cycle, including decreased density, decreased caliber, and changes in hair texture. Additionally, loss of estrogen after the onset of menopause may lead to sub-optimal metabolic and vascular functioning of the follicular unit. The overall decline in hair density, appearance and manageability can have significant emotional impact and affect overall mental health, with feelings of stress, anxiety, and diminished self-esteem. In addition to the physiologic changes that can occur in the hair follicle during menopause, certain hair disorders, including female-pattern hair loss, telogen effluvium, and frontal fibrosing alopecia, have been noted with higher frequency in post-menopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108378"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacist assessment of older adults' functional abilities to take their medication: a cross-sectional descriptive study in a geriatric acute care ward","authors":"Mathieu Corvaisier ,&nbsp;Charly Patry ,&nbsp;Olivier Briere ,&nbsp;Alexis Bourgeais ,&nbsp;Cédric Annweiler ,&nbsp;Laurence Spiesser-Robelet","doi":"10.1016/j.maturitas.2025.108382","DOIUrl":"10.1016/j.maturitas.2025.108382","url":null,"abstract":"<div><h3>Objectives</h3><div>Aging is associated with a decline in functional capacities, which can lead to challenges in medication preparation. Identifying these issues appears essential. The objectives of this study were to describe the proportion of pharmaceutical interventions carried out following the identification of patient difficulties in preparing and administering medications, and to characterize the difficulties identified.</div></div><div><h3>Study design</h3><div>Descriptive cross-sectional study with data collected during 42 pharmaceutical interviews with patients hospitalized on an acute geriatric ward. The interview consisted of two parts: i) a questionnaire assessing potential difficulties, and ii) direct observation of medication preparation using pharmaceutical forms similar to those usually prescribed to the patient.</div></div><div><h3>Main outcome measures</h3><div>The main outcome was the occurrence of at least one pharmaceutical intervention following the identification of difficulties.</div></div><div><h3>Results</h3><div>Pharmaceutical intervention was suggested to 95.0 % of patients where a difficulty was identified, representing 45.2 % of patients included. Interventions included education on correct use (16.0 %), substitution of pharmaceutical forms (16.0 %), implementation of tools for patients (36.0 %) and home assistance (32.0 %). These interventions were accepted by the geriatrician in all cases and by the patient in 80.0 %. At least one difficulty was identified for 47.7 % of the patients.</div></div><div><h3>Conclusions</h3><div>This study shows that identifying functional difficulties in medication preparation enables tailored interventions to address these issues. Observing older adults' abilities to manage their medication could reduce the risk of medication errors and probably enhance their daily quality of life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108382"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral microbiota profile is related to cognitive status in centenarians: a clinical and biological study","authors":"Giuseppina Campisciano ,&nbsp;Katia Rupel ,&nbsp;Federica D'Amico ,&nbsp;Mauro Tettamanti ,&nbsp;Filomena Vella ,&nbsp;Carolina Cason ,&nbsp;Manola Comar ,&nbsp;Silvia Turroni ,&nbsp;Gabriella Marcon","doi":"10.1016/j.maturitas.2025.108593","DOIUrl":"10.1016/j.maturitas.2025.108593","url":null,"abstract":"<div><h3>Objectives</h3><div>A growing body of evidence supports the potential role of the oral microbiota in influencing cognitive function. Centenarians, at the extreme end of the lifespan, are the ideal cohort to study the long-term effects of inflammaging.</div></div><div><h3>Study design</h3><div>Twenty-three centenarians were examined by a neurologist, neuropsychologist and dentist to assess cognitive status and oral health. They were also profiled for oral microbiota and inflammasome.</div></div><div><h3>Results</h3><div>We found less alpha diversity in the oral microbiota of participants with dementia and an overall depletion of typical oral commensals, including <em>Alloprevotella</em>, <em>Prevotella</em>, <em>Veillonella</em>, <em>Fusobacterium</em> and <em>Leptotrichia</em>. The latter two were also underrepresented in edentulous compared with dentate subjects. Moreover, levels of pro-inflammatory cytokines and chemokines tended to be higher in participants with dementia.</div></div><div><h3>Conclusions</h3><div>Our data support a relationship between oral microbiota, cognitive status and inflammation, which deserves further exploration to counteract cognitive decline while promoting healthy aging.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108593"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in frailty and incident diabetes in middle-aged and older adults: evidence from CHARLS","authors":"Xingge Li ,&nbsp;Ruilang Lin ,&nbsp;Lulu Pan ,&nbsp;Yuwei Peng ,&nbsp;Xiaorui Cui ,&nbsp;Shiyuan Wang ,&nbsp;Yongfu Yu","doi":"10.1016/j.maturitas.2025.108375","DOIUrl":"10.1016/j.maturitas.2025.108375","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate how changes in frailty affect diabetes risk and whether sex and age influence this relationship.</div></div><div><h3>Study design</h3><div>This prospective cohort study, based on the China Health and Retirement Longitudinal Study (CHARLS), included 11,221 adults aged 45 and over without diabetes before the second survey. The frailty index (FI), with scores ranging from 0 to 1, was administered at baseline (2011) and during the second survey (2013), categorizing participants as robust (FI ≤ 0.10), pre-frail (FI 0.10–0.25), or frail (FI ≥ 0.25). Frailty changes were determined from the two assessments.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was incident diabetes. Cox regression was used to assess the association of frailty changes with diabetes and whether this association differed by sex and age (≤65 years and &gt;65 years).</div></div><div><h3>Results</h3><div>During a median 7-year follow-up, 1197 developed diabetes. Those remaining pre-frail/frail had nearly double the risk of diabetes (HR 1.99, 95 % CI 1.70-2.33) compared with those remaining robust. Progressing from robust to pre-frail/frail increased risk (HR 1.80, 95 % CI 1.48-2.19), and improving from pre-frail/frail to robust still had an elevated risk (HR 1.32, 95 % CI 1.06-1.66). Higher FI tertile changes were linked to increased diabetes risk (HR 1.44, 95 % CI 1.24-1.67), with a significant trend (P &lt; 0.001). Women were at higher risk (P = 0.004), but age did not significantly modify the association (P = 0.972).</div></div><div><h3>Conclusions</h3><div>Frailty progression is strongly linked to increased risk of diabetes, especially in women, highlighting the need for targeted frailty management in diabetes prevention.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108375"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profiling of the Chinese population with extreme longevity identifies Lysophospholipid species as potential biomarkers for the human lifespan","authors":"Shaochang Wu ,&nbsp;He Li ,&nbsp;Maoqiang Yu ,&nbsp;Xiaogang Hu ,&nbsp;Shan Chao ,&nbsp;Fan Yang ,&nbsp;Shengying Qin","doi":"10.1016/j.maturitas.2025.108379","DOIUrl":"10.1016/j.maturitas.2025.108379","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic regulation plays a crucial role in extending the healthspan and lifespan across multiple organisms, including humans. Although numerous studies have identified the characteristics of the metabolome and potential biomarkers in long-lived populations worldwide, the metabolome landscape of Chinese centenarians remains largely unknown. This study characterised the plasma metabolic profiles of Chinese centenarians and nonagenarians and identified potential biomarkers of longevity.</div></div><div><h3>Methods</h3><div>A global untargeted metabolomics approach was used to analyze plasma samples from 65 centenarians (average age 101.72 ± 1.46 years), 53 nonagenarians (average age 98.92 ± 0.27 years), 47 older individuals (average age 64.66 ± 3.31 years), and 35 middle-aged participants (average age 33.91 ± 3.53 years) recruited from the Lishui region, an area of China well known for the longevity of its population.</div></div><div><h3>Results</h3><div>The plasma metabolic profiles of centenarians and nonagenarians differed significantly from those of the two younger populations. Specifically, 211 and 114 differentially abundant metabolites (DAMs) were identified in the centenarian and nonagenarian groups, respectively. The majority of these DAMs were glycerophosphoethanolamines, glycerophosphocholines, fatty esters, fatty alcohols, fatty acyls, and fatty acids and conjugates. For example, the circulating levels of LysoPA (20:2), LysoPA (20:3), LysoPC (16:0), LysoPC (18:2), and LysoPE (20:4) were significantly lower in centenarians than in the older and middle-aged groups. A similar pattern was also observed in the nonagenarian population. Notably, the plasma levels of five DAMs – LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), PG (18:0/18:1), and PG (18:1/18:2) – were significantly and continuously reduced with the ageing process. Pearson correlation analysis revealed that the reduced abundance of LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), LysoPE (24:0), PG (18:0/18:1), and PG (18:1/18:2) was significantly and negatively associated with lifespan, from middle-age to centenarian. ROC analysis indicated that LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), LysoPE (24:0), PG (18:0/18:1), and PG (18:1/18:2), as well as the combination of these six DAMs (AUC = 0.9074), had high predictive power for the human longevity phenotype.</div></div><div><h3>Conclusion</h3><div>This study elucidated the plasma metabolic landscape of centenarians and nonagenarians in China and identified several potential biomarkers for predicting human lifespan. Our findings will aid in understanding the metabolic regulation of longevity and may promote the clinical practice of gerontology in the future.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108379"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease and female sexual health across the life span: a bidirectional link","authors":"Anastasia Armeni ,&nbsp;Eleni Armeni ,&nbsp;Peter Chedraui ,&nbsp;Irene Lambrinoudaki","doi":"10.1016/j.maturitas.2025.108381","DOIUrl":"10.1016/j.maturitas.2025.108381","url":null,"abstract":"<div><div>Epidemiological research reveals that around 40 % of women aged 18–59 report significant concerns about their sexual experiences. Endothelial function and proper arterial blood flow through the hypogastric and pudendal arteries are critical in women for a normal vasculogenic response to sexual stimulation. Organic causes of female sexual dysfunction (FSD) often stem from neuropathy or vascular complications linked to cardiovascular risk factors. The relationship between cardiovascular disease (CVD) and FSD is multifactorial, influenced by various factors such as disease severity, physical and physiological factors, social determinants and factors related to medication use. Additionally, the pathophysiological mechanisms implicated in FSD of CVD patients include vascular, physical, psychological and hormonal factors. Hypertension, stroke, and myocardial infarction are closely interrelated with FSD, which is not the case for coronary heart disease, dyslipidemia, and peripheral obstructive artery disease. Hormonal treatment for sexual dysfunction in women with cardiovascular risk factors is discussed, concerning menopausal hormone therapy, tibolone, selective estrogen receptor modulators, vaginal estrogen, prasterone and testosterone therapy. On the other hand, the beneficial effect of sexual activity on cardiovascular health has been gaining supportive evidence. In healthy postmenopausal women aged 45–60, penile-vaginal intercourse has been suggested to positively influence cardiac autonomic functions, as indicated by heart rate variability. However, effectively addressing the challenges of aging and further highlighting the positive impact of sexual activity on cardiac health in selected female populations could significantly enhance life motivation and promote a healthy lifestyle during this stage. The present review elucidates the bidirectional relationship between CVD and female sexual function.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108381"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition as an index of the trabecular bone score in postmenopausal women","authors":"Maria Eleni Chondrogianni ,&nbsp;Ioannis Kyrou ,&nbsp;Theodoros Androutsakos ,&nbsp;Maria Panagaki ,&nbsp;Maria-Loukia Koutsompina ,&nbsp;Nektaria Papadopoulou-Marketou ,&nbsp;Despina Polichroniadi ,&nbsp;Grigorios Kaltsas ,&nbsp;Efstathios Efstathopoulos ,&nbsp;Maria Dalamaga ,&nbsp;Harpal S. Randeva ,&nbsp;Eva Kassi","doi":"10.1016/j.maturitas.2025.108273","DOIUrl":"10.1016/j.maturitas.2025.108273","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity is considered to exert a protective effect on bone mineral density (BMD). However, emerging data indicate that the effect of adipose tissue on bone health is much more complex. Trabecular bone score (TBS) provides information on bone texture and predicts fracture risk independently of BMD. This study investigated the association of body composition and bone quality as evaluated by lumbar spine (LS) TBS.</div></div><div><h3>Study design</h3><div>Cross-sectional study including 118 postmenopausal women (mean age 60.73 ± 8.97 years and mean BMI 28.36 ± 5.8) with no history of secondary osteoporosis or previous anti-osteoporotic treatment.</div></div><div><h3>Main outcome measures</h3><div>Body composition, BMD and LS TBS were evaluated by dual-energy X-ray absorptiometry (DXA). Τo explore the associations among the variables of interest, Spearman's correlations were used. Simple and multiple linear regression models were also applied to explore the associations among variables of interest.</div></div><div><h3>Results</h3><div>Visceral adipose tissue (VAT) mass, android fat mass and android/gynoid fat ratio were negative predictors of TBS (Stb = −0.413, <em>p</em> &lt; 0.001; Stb = −0.369, p &lt; 0.001; Stb = −0.333, p &lt; 0.001, respectively). Similarly, both the right (Stb = −0.313, p &lt; 0.001) and left arm fat mass (Stb = −0.313, p &lt; 0.001) were negative predictors of TBS. In a multiple linear regression model, VAT mass exhibited a significant negative association with TBS (Stb = −0.415, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The present study offers evidence that VAT mass has a negative association with bone texture as estimated by TBS in postmenopausal women. Moreover, the findings suggest that the body composition of the arms (arm fat mass) correlates inversely with the bone texture. Further research is required to validate these findings in large cohorts of postmenopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108273"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}