Maturitas最新文献

{"title":"Immunometabolic insights into women's health across all ages","authors":"Marta Matos-Silva ,&nbsp;Fábio Santos Lira ,&nbsp;Barbara Moura Antunes","doi":"10.1016/j.maturitas.2025.108719","DOIUrl":"10.1016/j.maturitas.2025.108719","url":null,"abstract":"<div><div>The reproductive phase in women is characterized by fluctuations in sex hormones, as observed during the menstrual cycle. With aging, hormonal transitions occur, leading to a decline in sex hormones and the onset of menopause. These hormonal fluctuations throughout a woman's life significantly impact immune cell activity and metabolism. This literature review elucidates the effects of female sex hormones, particularly estradiol, on immunometabolic modulation in adult and elderly women. Additionally, the review explores the impact of physical activity and exercise as strategies for modulating inflammation, metabolic changes, and preventing chronic non-communicable diseases (CNCDs). The findings indicate that during the menstrual cycle, sex hormones are significantly associated with inflammatory and lipid proteins, particularly pro-inflammatory markers (such as TNF-α, IL-1β, IL-6), LDL-c and non-HDL in the luteal phase, and influence the distribution of specific immune cells (such as monocytes and neutrophils). With the decline in sex hormone concentrations, evidence suggests that women experience a pronounced inflammatory profile, marked by significant secretion of pro-inflammatory cytokines due to a shift in immune cell phenotype, reinforcing the relationship between sex hormones and the inflammatory response. However, the literature is beginning to demonstrate more consistently the beneficial effects of exercise training, as it promotes the release of anti-inflammatory and protective markers (such as IL-10, IL-6, HDL-c, HDL/LDL ratio) through improvements in the cellular profile, directly contributing to an enhancement of the immunometabolic profile and the prevention of chronic diseases.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108719"},"PeriodicalIF":3.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns regarding prevalence estimates reported in the paper “Motoric cognitive risk syndrome and epigenetic aging”","authors":"Xiang Qi","doi":"10.1016/j.maturitas.2025.108717","DOIUrl":"10.1016/j.maturitas.2025.108717","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108717"},"PeriodicalIF":3.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply to Xiang Qi","authors":"Chao Han ,&nbsp;Xiaojun Zhang ,&nbsp;Sha Zhu ,&nbsp;Lihua Tao ,&nbsp;Jagadish K. Chhetri ,&nbsp;Piu Chan","doi":"10.1016/j.maturitas.2025.108718","DOIUrl":"10.1016/j.maturitas.2025.108718","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108718"},"PeriodicalIF":3.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical or cultural? Dietary interventions for lipedema: a systematic review","authors":"Jônatas de Oliveira ,&nbsp;Ana Carolina Padilha de Paula ,&nbsp;Victor Hugo Dantas Guimarães","doi":"10.1016/j.maturitas.2025.108716","DOIUrl":"10.1016/j.maturitas.2025.108716","url":null,"abstract":"<div><h3>Background</h3><div>Lipedema is a chronic, progressive condition characterized by symmetrical accumulation of adipose tissue, predominantly in women's lower extremities. It is frequently associated with pain, reduced mobility, and psychological distress. Dietary interventions have become central to conservative management of the condition, yet their clinical efficacy remains unclear.</div></div><div><h3>Methods</h3><div>This systematic review included peer-reviewed studies assessing dietary strategies in individuals with clinically diagnosed lipedema. Searches were conducted in four databases in July 2025, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible studies applied dietary interventions and reported clinical or psychosocial outcomes, and the risk of bias was subsequently assessed.</div></div><div><h3>Results</h3><div>Nine studies involving 269 women met the inclusion criteria. The majority applied hypocaloric dietary protocols, particularly ketogenic, low-carbohydrate high-fat, or ketogenic modified Mediterranean diets. Across studies, weight loss and reduction in fat mass were consistently reported. Some studies also observed improvements in pain, inflammation, and quality of life, though these outcomes were not uniformly assessed. Few studies used advanced measures of body composition such as dual-energy X-ray absorptiometry or magnetic resonance imaging; most relied on bioelectrical impedance analysis. Only one study evaluated emotional dysregulation and only one assessed food addiction, but no study systematically measured eating behavior traits, or current or past eating disorders. Intervention durations ranged from four to twenty-eight weeks, and adherence strategies varied. The risk of bias was moderate to high in most studies. Two trials (conducted by Lundanes and Jeziorek et al.) were randomized controlled trials, whereas the remaining studies used non-randomized designs despite including control and intervention groups. Due to the high heterogeneity in study design, outcomes, and measurement tools, combined with the small sample sizes and risk of bias, it was not possible to conduct a meta-analysis.</div></div><div><h3>Conclusion</h3><div>The effects of dietary approaches on lipedema remain unclear. Future studies should adopt robust methodological designs, include larger and stratified samples based on disease stage, use accurate assessments of body composition (including muscle mass and strength), evaluate mental health and eating behaviors, and investigate the long-term sustainability of interventions. The literature lacks standardized methodologies and comprehensive evaluation of psychosocial and eating behavior, highlighting the need for stronger evidence to inform clinical practice.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108716"},"PeriodicalIF":3.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to ambient air pollution and falls risk in a community-dwelling adult population","authors":"Dan Su ,&nbsp;Jie Chang ,&nbsp;Piu Chan","doi":"10.1016/j.maturitas.2025.108712","DOIUrl":"10.1016/j.maturitas.2025.108712","url":null,"abstract":"<div><h3>Background</h3><div>Falls are a major cause of disability. Whether exposure to ambient air pollution contributes to the occurrence of falls remains unclear.</div></div><div><h3>Objective</h3><div>To investigate the cross-sectional and longitudinal associations between ambient air pollution and the risk of falls in a community-dwelling adult population.</div></div><div><h3>Methods</h3><div>We included participants aged ≥45 years from the China Health and Retirement Longitudinal Study. Ambient air pollution was quantified as city levels of PM₂.₅ taken from the China High-Resolution Air Pollution dataset. Self-reported falls were the outcome of interest. Using group-based trajectory modelling, falls trajectories were investigated. Multivariable-adjusted logistic regression models were used to calculate the association between PM2.5 exposure and falls.</div></div><div><h3>Results</h3><div>A total of 9869 participants were divided into four groups according to their PM₂.₅ exposure: low, moderate, high, severely high. Two falls trajectories, low risk (74.3 %) and high risk (25.7 %), were observed. Exposure to moderate or high, but not severely high levels of PM₂.₅ elevated the risk of falls, compared with low levels of exposure cross-sectionally (Q2 (adj.OR 1.16, 95 % CI = 1.02–1.33), Q3 (adj.OR 1.29, 95 % CI = 1.13–1.47)) and longitudinally (Q3 (adj.OR 1.25, 95 % CI =1.10–1.43)). No significance for P for trend suggested non-linear associations. Females, individuals &gt;60 years and those with cognitive impairment were observed to have a higher risk of falls from exposure to moderate to high levels of ambient air pollution, but the interaction was statistically insignificant.</div></div><div><h3>Conclusion</h3><div>Being exposed to moderate and high PM₂.₅ levels was associated with an increased risk of falls among adults. The finding highlights the importance of air-quality improvement as a potential intervention to prevent falls in the community.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108712"},"PeriodicalIF":3.6,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis and menopausal health: An EMAS clinical guide","authors":"C. Tamer Erel ,&nbsp;Meletios P. Nigledis ,&nbsp;Ipek Betul Ozcivit Erkan ,&nbsp;Dimitrios G. Goulis ,&nbsp;Peter Chedraui ,&nbsp;Andrea Giannini ,&nbsp;Ludwig Kiesel ,&nbsp;Nancy Phillips ,&nbsp;Tommaso Simoncini ,&nbsp;Eleni Armeni ,&nbsp;Judith Boban ,&nbsp;Iuliana Ceausu ,&nbsp;Timothy Hillard ,&nbsp;Irene Lambrinoudaki ,&nbsp;Antonina Smetnik ,&nbsp;Marina Sprem Goldstajn ,&nbsp;Petra Stute ,&nbsp;Dorenda van Dijken ,&nbsp;Margaret Rees","doi":"10.1016/j.maturitas.2025.108715","DOIUrl":"10.1016/j.maturitas.2025.108715","url":null,"abstract":"<div><h3>Introduction</h3><div>Endometriosis is a common gynecological condition, and problems may persist or develop after the menopause. Endometriosis or its treatment in premenopausal women may lead to premature or early menopause. Thus, it is imperative that healthcare providers are appropriately trained in management of endometriosis at the menopause and beyond.</div></div><div><h3>Aim</h3><div>To provide an evidence-based clinical guide for the assessment and management of menopausal health in women with a history of endometriosis.</div></div><div><h3>Materials and methods</h3><div>Review of the literature and consensus of expert opinion.</div></div><div><h3>Summary recommendations</h3><div>Surgery is the preferred option for managing symptomatic endometriosis after the menopause, as it should reduce pain, ensure an accurate diagnosis, and decrease risk of malignancy. Women with endometriosis may experience a spontaneous early menopause or surgically induced menopause. Endometriosis is also associated with an increased risk of cardiovascular disease, ovarian, breast, and thyroid cancers, as well as osteoporosis. Menopausal hormone therapy (MHT) is indicated for managing vasomotor and genitourinary symptoms and maintaining bone health. Continuous combined MHT may be safer than other forms in both hysterectomized and non-hysterectomized women with endometriosis as the risk of recurrence and malignant transformation of residual endometriosis may be reduced. Estrogen-only MHT should be avoided, even for women who have had a hysterectomy. For women not using MHT, alternative pharmacological treatments, such as neurokinin-3 receptor antagonists, should be considered for managing vasomotor symptoms. Additionally, antiresorptive and anabolic therapies, along with calcium and vitamin D supplementation, should be provided as indicated to ensure skeletal protection. If endometriosis recurs during MHT use and the patient is symptomatic, several management strategies may be employed: altering the regimen, discontinuation, and use of non-hormonal strategies. Herbal preparations should be avoided as their efficacy is uncertain and some may contain estrogenic compounds.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108715"},"PeriodicalIF":3.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in gaze patterns while viewing dynamic and static sexual scenes","authors":"Vesa Putkinen ,&nbsp;Elina Lewandowski ,&nbsp;Severi Santavirta ,&nbsp;Lauri Nummenmaa","doi":"10.1016/j.maturitas.2025.108714","DOIUrl":"10.1016/j.maturitas.2025.108714","url":null,"abstract":"<div><h3>Objectives</h3><div>Faces and bodies serve as important cues of physical attractiveness and reproductive fitness. Previous studies indicate that there are sex-related differences in the visual processing of erotic stimuli. We investigated gaze patterns and sex differences during sexual perception.</div></div><div><h3>Study design</h3><div>We measured the eye movements of 43 male and 67 female subjects while viewing sexual scenes (intercourse; Experiment 1) and static erotic stimuli (nude and clothed men and women; Experiment 2) in a cross-sectional study.</div></div><div><h3>Main outcome measures</h3><div>For each region of interest (ROI; face, chest, genitals, back) we computed mean pupil size, gaze duration, first fixation latency and first fixation duration. Intersubject correlation of eye movements (eISC) was computed to assess similarity of gaze patterns across viewers.</div></div><div><h3>Results</h3><div>Dwell times were the longest for faces and faces were the most likely to be looked at first. In Experiment 1, males looked more at female chest, buttocks, and genital areas while female participants looked more at male faces. In Experiment 2, faces received more fixations for clothed stimuli, whereas chest and genital areas received more fixations for nude stimuli.</div></div><div><h3>Conclusions</h3><div>Sex differences during sexual perception are larger for static versus dynamic stimuli. Faces are prioritized over sexual signals, and visibility of sexual cues increases saliency of the sexually relevant body regions. The preference for faces even when viewing sexual intercourse may reflect both the importance of facial characteristics in mate selection as well as the role of facial expressions in evaluating partner satisfaction while having sex.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108714"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of nonpharmacological interventions for menopause-related insomnia: A systematic review and Bayesian network meta-analysis","authors":"Zhongli Wang ,&nbsp;Haoyu Yang ,&nbsp;Shutong Li ,&nbsp;Lu Cheng ,&nbsp;Yuan Yuan ,&nbsp;Ying Bai ,&nbsp;Jianbang Su ,&nbsp;Yiqi Li ,&nbsp;Tao Wang ,&nbsp;Zhenhua Xu","doi":"10.1016/j.maturitas.2025.108713","DOIUrl":"10.1016/j.maturitas.2025.108713","url":null,"abstract":"<div><h3>Background</h3><div>Nonpharmacological therapies are widely used to improve the sleep quality of menopausal women experiencing insomnia. It is necessary to clarify which of the nonpharmacological therapies studied in randomized controlled trials are most effective and comprehensively evaluate their impacts.</div></div><div><h3>Method</h3><div>We conducted a systematic search across PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Web of Science from their inception until May 25, 2025. To analyze and visualize our results, we utilized the “BUGSnet” and “JAGS” packages within the R statistical software. Employing a random-effects model, we calculated effect sizes as mean differences (MD) for continuous outcomes. Furthermore, we performed a quality assessment of our study using the RoB2 tool.</div></div><div><h3>Results</h3><div>Out of 1925 studies screened, 44 were included in the final analysis. The findings revealed that, compared with a control condition, relaxation, cognitive behavioral therapy, mindfulness, aromatherapy, acupuncture, massage, yoga and exercise all significantly improved sleep quality. The MD values ranged from −5.61 (95 % CrI: −8.70 to −2.50) for mindfulness to −2.40 (95 % CrI: −4.19 to −0.62) for exercise. Mindfulness was also the most effective based on SUCRA.</div></div><div><h3>Conclusion</h3><div>Relaxation, cognitive behavioral therapy, mindfulness, aromatherapy, acupuncture, massage, yoga and exercise all significantly improve sleep quality and mindfulness is the most effective.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108713"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetarian diets for longevity: friend or foe?","authors":"Maria G. Grammatikopoulou ,&nbsp;Kalliopi K. Gkouskou ,&nbsp;Arriana Gkouvi ,&nbsp;Dimitrios P. Bogdanos ,&nbsp;Irene Lambrinoudaki ,&nbsp;Dimitrios G. Goulis","doi":"10.1016/j.maturitas.2025.108711","DOIUrl":"10.1016/j.maturitas.2025.108711","url":null,"abstract":"<div><div>Vegetarianism is a healthy dietary pattern that is postulated to increase longevity. Vegetarianism is adopted for animal ethics, environmental reasons, or religious beliefs. Vegetarian diets are believed to improve the gut microbiome, body weight, cardiovascular health and inflammation; however, a synthesis of the up-to-date evidence does not seem to support these effects. When objective measures are sought, it becomes apparent that there is a lack of high-quality evidence regarding the effect of vegetarian diets on telomere length. Moreover, studies indicating lower mortality rates for vegetarians than for meat eaters appear to be highly biased. Among the geographical areas with higher-than-expected numbers of centenarians (‘blue zones’), only one site is largely inhabited by vegetarians, whereas the rest have populations largely of flexitarians. Overall, available research does not indicate the superiority of vegetarian diets over flexitarian ones. The issue merits further research to help us understand vegetarianism's effects on longevity.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108711"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in femoral 3D-DXA cortical and trabecular indices in postmenopausal women with early breast cancer treated with aromatase inhibitors: a prospective study of the B-ABLE cohort","authors":"Natalia Garcia-Giralt ,&nbsp;Diana Ovejero ,&nbsp;Sonia Servitja ,&nbsp;Ludovic Humbert ,&nbsp;Tamara Martos ,&nbsp;Anna Ribes ,&nbsp;Jade Soldado-Folgado ,&nbsp;Xavier Nogués","doi":"10.1016/j.maturitas.2025.108708","DOIUrl":"10.1016/j.maturitas.2025.108708","url":null,"abstract":"<div><h3>Objectives</h3><div>This observational prospective study evaluated bone changes using 3D-DXA in the B-ABLE cohort of postmenopausal women with early breast cancer receiving aromatase inhibitors (AI).</div></div><div><h3>Study design</h3><div>Hip DXA scans were performed before initiating AI therapy and on a yearly basis until its completion: 5 years of AI therapy (5y-AI group) or 2–3 years of AI therapy after switching from 2 or 3 years of tamoxifen (pTMX-AI group). 3D-DXA analysis was performed using 3D-Shaper® software. Patients with osteoporosis or high fracture risk at baseline started antiresorptive treatment (ARP).</div></div><div><h3>Main outcome measures</h3><div>Cumulative changes in areal bone mineral density (aBMD) and 3D-DXA-derived parameters, including cortical surface BMD, cortical thickness, and integral, cortical, and trabecular volumetric BMD (vBMD), were evaluated by linear mixed models considering ARP and previous tamoxifen treatment.</div></div><div><h3>Results</h3><div>Of a total of 785 women included, 191 (24.3 %) started ARP at baseline. Non-ARP-treated patients had a decrease of more than 4 % in all bone parameters at the end of AI treatment, except cortical thickness, which displayed minimum changes. Women previously treated with TMX had significantly greater losses in most parameters, which occurred mainly during the first year of AI treatment.</div><div>In ARP-treated patients, a significant increase was detected in all bone parameters, especially in the 5y-AI group. Denosumab showed greater efficacy than bisphosphonate in improving most bone parameters.</div></div><div><h3>Conclusions</h3><div>3D-DXA provides deeper insights into the detrimental changes in the cortical and trabecular bone compartment caused by AI, and how ARP can prevent these effects.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108708"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}