Maturitas最新文献

{"title":"Clinical pharmacist assessment of older adults' functional abilities to take their medication: a cross-sectional descriptive study in a geriatric acute care ward","authors":"Mathieu Corvaisier ,&nbsp;Charly Patry ,&nbsp;Olivier Briere ,&nbsp;Alexis Bourgeais ,&nbsp;Cédric Annweiler ,&nbsp;Laurence Spiesser-Robelet","doi":"10.1016/j.maturitas.2025.108382","DOIUrl":"10.1016/j.maturitas.2025.108382","url":null,"abstract":"<div><h3>Objectives</h3><div>Aging is associated with a decline in functional capacities, which can lead to challenges in medication preparation. Identifying these issues appears essential. The objectives of this study were to describe the proportion of pharmaceutical interventions carried out following the identification of patient difficulties in preparing and administering medications, and to characterize the difficulties identified.</div></div><div><h3>Study design</h3><div>Descriptive cross-sectional study with data collected during 42 pharmaceutical interviews with patients hospitalized on an acute geriatric ward. The interview consisted of two parts: i) a questionnaire assessing potential difficulties, and ii) direct observation of medication preparation using pharmaceutical forms similar to those usually prescribed to the patient.</div></div><div><h3>Main outcome measures</h3><div>The main outcome was the occurrence of at least one pharmaceutical intervention following the identification of difficulties.</div></div><div><h3>Results</h3><div>Pharmaceutical intervention was suggested to 95.0 % of patients where a difficulty was identified, representing 45.2 % of patients included. Interventions included education on correct use (16.0 %), substitution of pharmaceutical forms (16.0 %), implementation of tools for patients (36.0 %) and home assistance (32.0 %). These interventions were accepted by the geriatrician in all cases and by the patient in 80.0 %. At least one difficulty was identified for 47.7 % of the patients.</div></div><div><h3>Conclusions</h3><div>This study shows that identifying functional difficulties in medication preparation enables tailored interventions to address these issues. Observing older adults' abilities to manage their medication could reduce the risk of medication errors and probably enhance their daily quality of life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108382"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral microbiota profile is related to cognitive status in centenarians: a clinical and biological study","authors":"Giuseppina Campisciano ,&nbsp;Katia Rupel ,&nbsp;Federica D'Amico ,&nbsp;Mauro Tettamanti ,&nbsp;Filomena Vella ,&nbsp;Carolina Cason ,&nbsp;Manola Comar ,&nbsp;Silvia Turroni ,&nbsp;Gabriella Marcon","doi":"10.1016/j.maturitas.2025.108593","DOIUrl":"10.1016/j.maturitas.2025.108593","url":null,"abstract":"<div><h3>Objectives</h3><div>A growing body of evidence supports the potential role of the oral microbiota in influencing cognitive function. Centenarians, at the extreme end of the lifespan, are the ideal cohort to study the long-term effects of inflammaging.</div></div><div><h3>Study design</h3><div>Twenty-three centenarians were examined by a neurologist, neuropsychologist and dentist to assess cognitive status and oral health. They were also profiled for oral microbiota and inflammasome.</div></div><div><h3>Results</h3><div>We found less alpha diversity in the oral microbiota of participants with dementia and an overall depletion of typical oral commensals, including <em>Alloprevotella</em>, <em>Prevotella</em>, <em>Veillonella</em>, <em>Fusobacterium</em> and <em>Leptotrichia</em>. The latter two were also underrepresented in edentulous compared with dentate subjects. Moreover, levels of pro-inflammatory cytokines and chemokines tended to be higher in participants with dementia.</div></div><div><h3>Conclusions</h3><div>Our data support a relationship between oral microbiota, cognitive status and inflammation, which deserves further exploration to counteract cognitive decline while promoting healthy aging.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108593"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in frailty and incident diabetes in middle-aged and older adults: evidence from CHARLS","authors":"Xingge Li ,&nbsp;Ruilang Lin ,&nbsp;Lulu Pan ,&nbsp;Yuwei Peng ,&nbsp;Xiaorui Cui ,&nbsp;Shiyuan Wang ,&nbsp;Yongfu Yu","doi":"10.1016/j.maturitas.2025.108375","DOIUrl":"10.1016/j.maturitas.2025.108375","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate how changes in frailty affect diabetes risk and whether sex and age influence this relationship.</div></div><div><h3>Study design</h3><div>This prospective cohort study, based on the China Health and Retirement Longitudinal Study (CHARLS), included 11,221 adults aged 45 and over without diabetes before the second survey. The frailty index (FI), with scores ranging from 0 to 1, was administered at baseline (2011) and during the second survey (2013), categorizing participants as robust (FI ≤ 0.10), pre-frail (FI 0.10–0.25), or frail (FI ≥ 0.25). Frailty changes were determined from the two assessments.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was incident diabetes. Cox regression was used to assess the association of frailty changes with diabetes and whether this association differed by sex and age (≤65 years and &gt;65 years).</div></div><div><h3>Results</h3><div>During a median 7-year follow-up, 1197 developed diabetes. Those remaining pre-frail/frail had nearly double the risk of diabetes (HR 1.99, 95 % CI 1.70-2.33) compared with those remaining robust. Progressing from robust to pre-frail/frail increased risk (HR 1.80, 95 % CI 1.48-2.19), and improving from pre-frail/frail to robust still had an elevated risk (HR 1.32, 95 % CI 1.06-1.66). Higher FI tertile changes were linked to increased diabetes risk (HR 1.44, 95 % CI 1.24-1.67), with a significant trend (P &lt; 0.001). Women were at higher risk (P = 0.004), but age did not significantly modify the association (P = 0.972).</div></div><div><h3>Conclusions</h3><div>Frailty progression is strongly linked to increased risk of diabetes, especially in women, highlighting the need for targeted frailty management in diabetes prevention.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108375"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profiling of the Chinese population with extreme longevity identifies Lysophospholipid species as potential biomarkers for the human lifespan","authors":"Shaochang Wu ,&nbsp;He Li ,&nbsp;Maoqiang Yu ,&nbsp;Xiaogang Hu ,&nbsp;Shan Chao ,&nbsp;Fan Yang ,&nbsp;Shengying Qin","doi":"10.1016/j.maturitas.2025.108379","DOIUrl":"10.1016/j.maturitas.2025.108379","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic regulation plays a crucial role in extending the healthspan and lifespan across multiple organisms, including humans. Although numerous studies have identified the characteristics of the metabolome and potential biomarkers in long-lived populations worldwide, the metabolome landscape of Chinese centenarians remains largely unknown. This study characterised the plasma metabolic profiles of Chinese centenarians and nonagenarians and identified potential biomarkers of longevity.</div></div><div><h3>Methods</h3><div>A global untargeted metabolomics approach was used to analyze plasma samples from 65 centenarians (average age 101.72 ± 1.46 years), 53 nonagenarians (average age 98.92 ± 0.27 years), 47 older individuals (average age 64.66 ± 3.31 years), and 35 middle-aged participants (average age 33.91 ± 3.53 years) recruited from the Lishui region, an area of China well known for the longevity of its population.</div></div><div><h3>Results</h3><div>The plasma metabolic profiles of centenarians and nonagenarians differed significantly from those of the two younger populations. Specifically, 211 and 114 differentially abundant metabolites (DAMs) were identified in the centenarian and nonagenarian groups, respectively. The majority of these DAMs were glycerophosphoethanolamines, glycerophosphocholines, fatty esters, fatty alcohols, fatty acyls, and fatty acids and conjugates. For example, the circulating levels of LysoPA (20:2), LysoPA (20:3), LysoPC (16:0), LysoPC (18:2), and LysoPE (20:4) were significantly lower in centenarians than in the older and middle-aged groups. A similar pattern was also observed in the nonagenarian population. Notably, the plasma levels of five DAMs – LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), PG (18:0/18:1), and PG (18:1/18:2) – were significantly and continuously reduced with the ageing process. Pearson correlation analysis revealed that the reduced abundance of LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), LysoPE (24:0), PG (18:0/18:1), and PG (18:1/18:2) was significantly and negatively associated with lifespan, from middle-age to centenarian. ROC analysis indicated that LysoPA (20:3), LysoPC (18:2), LysoPE (20:4), LysoPE (24:0), PG (18:0/18:1), and PG (18:1/18:2), as well as the combination of these six DAMs (AUC = 0.9074), had high predictive power for the human longevity phenotype.</div></div><div><h3>Conclusion</h3><div>This study elucidated the plasma metabolic landscape of centenarians and nonagenarians in China and identified several potential biomarkers for predicting human lifespan. Our findings will aid in understanding the metabolic regulation of longevity and may promote the clinical practice of gerontology in the future.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108379"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease and female sexual health across the life span: a bidirectional link","authors":"Anastasia Armeni ,&nbsp;Eleni Armeni ,&nbsp;Peter Chedraui ,&nbsp;Irene Lambrinoudaki","doi":"10.1016/j.maturitas.2025.108381","DOIUrl":"10.1016/j.maturitas.2025.108381","url":null,"abstract":"<div><div>Epidemiological research reveals that around 40 % of women aged 18–59 report significant concerns about their sexual experiences. Endothelial function and proper arterial blood flow through the hypogastric and pudendal arteries are critical in women for a normal vasculogenic response to sexual stimulation. Organic causes of female sexual dysfunction (FSD) often stem from neuropathy or vascular complications linked to cardiovascular risk factors. The relationship between cardiovascular disease (CVD) and FSD is multifactorial, influenced by various factors such as disease severity, physical and physiological factors, social determinants and factors related to medication use. Additionally, the pathophysiological mechanisms implicated in FSD of CVD patients include vascular, physical, psychological and hormonal factors. Hypertension, stroke, and myocardial infarction are closely interrelated with FSD, which is not the case for coronary heart disease, dyslipidemia, and peripheral obstructive artery disease. Hormonal treatment for sexual dysfunction in women with cardiovascular risk factors is discussed, concerning menopausal hormone therapy, tibolone, selective estrogen receptor modulators, vaginal estrogen, prasterone and testosterone therapy. On the other hand, the beneficial effect of sexual activity on cardiovascular health has been gaining supportive evidence. In healthy postmenopausal women aged 45–60, penile-vaginal intercourse has been suggested to positively influence cardiac autonomic functions, as indicated by heart rate variability. However, effectively addressing the challenges of aging and further highlighting the positive impact of sexual activity on cardiac health in selected female populations could significantly enhance life motivation and promote a healthy lifestyle during this stage. The present review elucidates the bidirectional relationship between CVD and female sexual function.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108381"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition as an index of the trabecular bone score in postmenopausal women","authors":"Maria Eleni Chondrogianni ,&nbsp;Ioannis Kyrou ,&nbsp;Theodoros Androutsakos ,&nbsp;Maria Panagaki ,&nbsp;Maria-Loukia Koutsompina ,&nbsp;Nektaria Papadopoulou-Marketou ,&nbsp;Despina Polichroniadi ,&nbsp;Grigorios Kaltsas ,&nbsp;Efstathios Efstathopoulos ,&nbsp;Maria Dalamaga ,&nbsp;Harpal S. Randeva ,&nbsp;Eva Kassi","doi":"10.1016/j.maturitas.2025.108273","DOIUrl":"10.1016/j.maturitas.2025.108273","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity is considered to exert a protective effect on bone mineral density (BMD). However, emerging data indicate that the effect of adipose tissue on bone health is much more complex. Trabecular bone score (TBS) provides information on bone texture and predicts fracture risk independently of BMD. This study investigated the association of body composition and bone quality as evaluated by lumbar spine (LS) TBS.</div></div><div><h3>Study design</h3><div>Cross-sectional study including 118 postmenopausal women (mean age 60.73 ± 8.97 years and mean BMI 28.36 ± 5.8) with no history of secondary osteoporosis or previous anti-osteoporotic treatment.</div></div><div><h3>Main outcome measures</h3><div>Body composition, BMD and LS TBS were evaluated by dual-energy X-ray absorptiometry (DXA). Τo explore the associations among the variables of interest, Spearman's correlations were used. Simple and multiple linear regression models were also applied to explore the associations among variables of interest.</div></div><div><h3>Results</h3><div>Visceral adipose tissue (VAT) mass, android fat mass and android/gynoid fat ratio were negative predictors of TBS (Stb = −0.413, <em>p</em> &lt; 0.001; Stb = −0.369, p &lt; 0.001; Stb = −0.333, p &lt; 0.001, respectively). Similarly, both the right (Stb = −0.313, p &lt; 0.001) and left arm fat mass (Stb = −0.313, p &lt; 0.001) were negative predictors of TBS. In a multiple linear regression model, VAT mass exhibited a significant negative association with TBS (Stb = −0.415, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The present study offers evidence that VAT mass has a negative association with bone texture as estimated by TBS in postmenopausal women. Moreover, the findings suggest that the body composition of the arms (arm fat mass) correlates inversely with the bone texture. Further research is required to validate these findings in large cohorts of postmenopausal women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108273"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital mental health tools: A narrative review on overcoming barriers in the age of displacement and disparities","authors":"Lara Anne Bridge ,&nbsp;James Elsey ,&nbsp;Pierre Pratley ,&nbsp;Aniek Woodward","doi":"10.1016/j.maturitas.2025.108380","DOIUrl":"10.1016/j.maturitas.2025.108380","url":null,"abstract":"<div><div>Over the past decade, digital health tools have gained traction as a promising solution to meet the growing healthcare demands of an ageing population. Refugee populations, in particular, face heightened risks of adverse ageing due to ongoing stressors that contribute to a high mental health burden. Digital health tools offer the potential to provide cost-effective, accessible, and scalable mental health care for refugees. However, these technologies are often not designed with marginalised and socially disadvantaged groups in mind, limiting their suitability for refugee populations. This narrative review critically examines the supply-side (characteristics of the mental health system) and demand-side (characteristics of the patient population) barriers of digital health tools for refugee mental health. Key supply-side barriers include the appropriateness of services and systemic challenges. On the demand side, the utilisation of services is threatened by low awareness, intentions, access, capacity, and adherence. We explore potential solutions, emphasising hybrid models incorporating community involvement and adopting a systems approach to co-designing digital health tools. By addressing these challenges, digital health tools can be tailored towards those previously underserved, to promote mental health and healthy ageing.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108380"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of physical activity on sleep in women experiencing vasomotor symptoms during menopause: a systematic review and meta-analysis","authors":"Adriano Bruno Corrêa,&nbsp;Mateus do Carmo Bardella,&nbsp;Arthur Polveiro da Silva,&nbsp;Matheus Martins Moreira,&nbsp;Luís Felipe Pengo Almeida Leite,&nbsp;Camila de Moraes","doi":"10.1016/j.maturitas.2025.108271","DOIUrl":"10.1016/j.maturitas.2025.108271","url":null,"abstract":"<div><div>Hot flashes and night sweats, common vasomotor symptoms (VMS) during menopause, are strongly associated with poor sleep quality and disorders. Physical activity is proposed as a strategy to improve menopausal health and sleep outcomes. This systematic review and meta-analysis synthesizes and evaluates evidence on the relationship between physical activity and sleep parameters in women experiencing VMS. Comprehensive searches were conducted in October 2024 across multiple databases, including MEDLINE/PubMed, Cochrane Library, and EMBASE, alongside manual backward and forward searches. Randomized controlled trials (RCTs) investigating physical activity or exercise interventions and their effects on subjective and objective sleep outcomes in women with VMS were included. The risk of bias was assessed using the revised Cochrane RoB 2 tool, and data were pooled for meta-analysis. Nine studies with a total of 1579 participants were analyzed. Physical activity interventions did not significantly improve sleep quality (-0.03 [-1.23, 1.18]; <em>P</em> = 0.96; I² = 78 %) or insomnia (−1.65 [−3.52, 0.21]; <em>P</em> = 0.08; I² = 0 %) but produced minor improvements in sleep problems (−0.08 [−0.16, −0.00]; <em>P</em> = 0.04; I² = 0 %). Despite concerns regarding bias, none of the studies were classified as high-risk, supporting result reliability. The findings suggest heterogeneity in the effects of physical activity on sleep, influenced by intervention-specific factors like type, frequency, intensity, timing, and duration. Environmental variables may also moderate these outcomes, highlighting the complexity of sleep regulation and the need for tailored approaches to improve sleep in menopausal women.</div><div>Review protocol is registered in PROSPERO: CRD42024599593</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"198 ","pages":"Article 108271"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility and effects of a telehealth-delivered physical therapy program for postmenopausal women with urinary incontinence: A pilot mixed-methods study","authors":"Kuan-Yin Lin ,&nbsp;Chao-Yin Chen ,&nbsp;Pei-Chi Wu ,&nbsp;Min-Hsuan Huang ,&nbsp;Yin-Chien Ou ,&nbsp;Yao-Lin Kao ,&nbsp;Kuan-Han Lin","doi":"10.1016/j.maturitas.2025.108376","DOIUrl":"10.1016/j.maturitas.2025.108376","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the feasibility and effectiveness of a telehealth-delivered pelvic floor muscle training program for postmenopausal women with urinary incontinence, in comparison with face-to-face pelvic floor muscle training.</div></div><div><h3>Stud design</h3><div>This was a pilot mixed-methods study that included a non-inferiority randomized controlled trial with a nested qualitative study. Community-dwelling postmenopausal women (&gt;40 years) with urinary incontinence were recruited and randomly allocated to 12 weeks of telehealth or face-to-face pelvic floor muscle training. The face-to-face group received supervised training twice weekly, while the telehealth group had eight virtual sessions plus weekly telephone coaching.</div></div><div><h3>Main outcome measures</h3><div>Assessments at baseline, post-intervention, and three-month follow-up included feasibility, anthropometry, body composition, hand grip strength, functional exercise capacity, physical activity levels, the severity of urinary incontinence, and pelvic floor muscle function (assessed through vaginal manometry, transperineal ultrasound, and digital palpation).</div></div><div><h3>Results</h3><div>Among 55 potential participants, 22 enrolled (40 % consent rate). Attendance was 100 %, with 63.3 % adherence to the home program. Satisfaction was high (very satisfied: 71 % face-to-face, 89 % telehealth). Both groups reported increased confidence in pelvic floor muscle training. Urinary symptoms and pelvic floor function improved in both groups, with benefits sustained at three months. Telehealth pelvic floor muscle training also enhanced grip strength. No significant differences were found between groups.</div></div><div><h3>Conclusions</h3><div>Telehealth pelvic floor muscle training appears to be a feasible and potentially effective alternative to face-to-face therapy for postmenopausal women with urinary incontinence. Larger studies are needed to confirm these preliminary findings and guide future interventions.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (<span><span>NCT05970796</span><svg><path></path></svg></span>); date of registration: 29/07/2023.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108376"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the use of menopausal hormone therapy in France, 2001–2023","authors":"Rafael Amaro Costa ,&nbsp;Ana-Maria Vilcu ,&nbsp;Manon Cairat ,&nbsp;Eléa Olivier ,&nbsp;Anne C.M. Thiébaut ,&nbsp;Agnès Fournier","doi":"10.1016/j.maturitas.2025.108270","DOIUrl":"10.1016/j.maturitas.2025.108270","url":null,"abstract":"<div><h3>Objectives</h3><div>Few studies have examined trends in the use of menopausal hormone therapy (MHT) from the early 2010s onwards. Furthermore, data from the period after the release of the results of the Women's Health Initiative in 2002 are rarely reported with a distinction between systemic and local MHT. We therefore describe trends in the use of systemic and local MHT in France during the period 2001–2023.</div></div><div><h3>Study design</h3><div>Descriptive study using annual drug claim data aggregated at the national level from two French open-source databases.</div></div><div><h3>Main outcome measures</h3><div>The annual (2001-2023) number of estrogen-based MHT boxes reimbursed by the French National Health Insurance system was extracted and classified according to the route of administration. From 2014 onwards, data on the number of consumers of each estrogen-based MHT preparation, available by age categories, was used to further estimate the number of individuals using MHT, overall and by MHT type (systemic/local).</div></div><div><h3>Results</h3><div>The annual number of MHT claims fell from 25.0 to 6.3 million boxes between 2001 and 2023. Systemic MHT products almost exclusively accounted for this fall, while local MHT use remained rather stable. We estimated that, in 2023, local MHT was used by 1.1 million individuals (0.44 million aged 20–59 years and 0.67 aged 60+ years) and systemic MHT by 0.5 million (0.37 million aged 20–59 years and 0.16 million aged 60+ years).</div></div><div><h3>Conclusions</h3><div>In France, the use of systemic MHT has plummeted since 2001, while use of local MHT has remained stable. Claims for local MHT now represent more than half of all MHT claims in France.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108270"},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}