Maturitas最新文献

{"title":"Effects of cardiac rehabilitation on female patients with heart disease: A systematic review and meta-analysis","authors":"Ayami Osumi ,&nbsp;Yuji Kanejima ,&nbsp;Masahiro Kitamura ,&nbsp;Kodai Ishihara ,&nbsp;Kazuhiro P. Izawa","doi":"10.1016/j.maturitas.2025.108653","DOIUrl":"10.1016/j.maturitas.2025.108653","url":null,"abstract":"<div><div>In recent years, “women-focused cardiac rehabilitation” or “women-only cardiac rehabilitation” has been implemented to address low referral, participation, and adherence among women in conventional cardiac rehabilitation programs. This review examined the effects of women-focused cardiac rehabilitation on psychological and physical outcomes and program adherence. Randomized clinical trials with patients 18 years and older with cardiovascular disease that provided women-focused cardiac rehabilitation and assessed at least one of the outcomes of psychological impacts, physical impacts, or adherence were included. Literature searches were conducted in PubMed, Web of Science, and CiNii from inception to April 9, 2024. Meta-analyses were performed using “EZR” software. From 653 relevant studies identified, 16 studies were included. Women-focused cardiac rehabilitation significantly improved depressive symptoms (standardized mean difference = −0.40, 95 % confidence interval [−0.61, −0.19]) but had no significant effect on anxiety (standardized mean difference = −0.15, 95 % confidence interval [−0.55, 0.25]). Some studies suggested potential improvements in quality of life and 6-min walk distance, although effect sizes varied and many outcomes were not statistically significant. Tailored or supervised cardiac rehabilitation was also associated with high adherence to both exercise and educational programs in some studies. Due to the small number of studies per outcome, variability in intervention formats, and the overall high risk of bias, conclusions should be interpreted with caution. Women-focused cardiac rehabilitation may provide psychological benefits, particularly in reducing depressive symptoms, but further high-quality trials are needed to better understand its effects on physical outcomes and adherence.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108653"},"PeriodicalIF":3.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of a second primary cancer after breast cancer in Southern Spain: a population-based study over 3 decades","authors":"Javier Casquero-Sánchez ,&nbsp;Luis Miguel Martín-de Los Reyes ,&nbsp;Miguel Rodríguez-Barranco ,&nbsp;Dafina Petrova ,&nbsp;Oscar Mendoza-García ,&nbsp;Daniel Redondo ,&nbsp;Encarnación González-Flores ,&nbsp;María-José Sánchez","doi":"10.1016/j.maturitas.2025.108647","DOIUrl":"10.1016/j.maturitas.2025.108647","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the risk of developing a second primary cancer (SPC) among women diagnosed with breast cancer in Granada, Spain.</div></div><div><h3>Study design</h3><div>This population-based observational cohort study utilized data from the Granada Cancer Registry. We included all women aged 15 and above diagnosed with malignant breast cancer from 1985 to 2019.</div></div><div><h3>Main outcome measures</h3><div>The analysis used the standardized incidence ratio to compare breast cancer patients' risk of developing a SPC with the risk in the general population.</div></div><div><h3>Results</h3><div>Out of 12,260 women diagnosed with breast cancer, 1032 (8.4 %) developed a SPC. The median time to SPC diagnosis was 7.2 years. The most common types of SPC were non-melanoma skin, colorectal, endometrial and haematological malignancies. The overall excess risk of a SPC was 33 % (95 % CI = 25 %–41 %), with the highest increased risks observed for non-melanoma skin, digestive, and genitourinary malignancies. The risk of a SPC was 2.2 times greater than expected in women under 50, and 1.2 times in women over 50. For those under 50, the risk was nearly 6 times higher for digestive sites, and 3 to 5 times higher for lung, non-melanoma skin, genitourinary, and haematological cancers. In women over 50, excess risks were also observed in those sites, but to a lesser extent.</div></div><div><h3>Conclusions</h3><div>Women with breast cancer have a significantly increased risk of developing a SPC, especially non-melanoma skin, digestive, and genitourinary cancers. Personalized prevention and follow-up strategies are needed to reduce the risk in women diagnosed with breast cancer, particularly younger women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108647"},"PeriodicalIF":3.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A genome-wide association study for lifetime estrogen exposure identifies novel loci and polygenic signals in East Asian postmenopausal women","authors":"Minju Yuk ,&nbsp;Soyoun Yang ,&nbsp;Dabin Yun ,&nbsp;Kwangyeon Oh ,&nbsp;Ji Min Han ,&nbsp;Key-Hwan Lim ,&nbsp;Qian Dong ,&nbsp;Zhaoming Wang ,&nbsp;Nan Song","doi":"10.1016/j.maturitas.2025.108645","DOIUrl":"10.1016/j.maturitas.2025.108645","url":null,"abstract":"<div><h3>Objective</h3><div>Estrogen exposure is the principal indicator of reproductive health and aging in women. We sought to identify what genetic factors affected lifetime estrogen exposure in a population of East Asian women.</div></div><div><h3>Methods</h3><div>We conducted a genome-wide association study (GWAS) on estimated lifetime estrogen exposure (ELEE) in 21,724 postmenopausal women from the Korean Genome and Epidemiology Study. A linear regression model adjusted for age at survey and breastfeeding status was analyzed separately in three independent subcohorts, and summary statistics were then combined via a meta-analysis.</div></div><div><h3>Results</h3><div>Based on GWAS, we identified 10 single-nucleotide polymorphisms (SNPs) associated with ELEE, including one novel SNP, rs9992072. The most significant association with ELEE was for rs13438 on chromosome 3 (<em>H1–10</em>, beta (standard error) = 0.4705 (0.06), <em>P</em> = 4.09 × 10⁻¹⁷). An increase in polygenic risk score (PRS) by one standard deviation was associated with a 0.44-year increase in ELEE. Additionally, the PRS was associated with breast cancer and diabetes (<em>P</em> &lt; 0.05). Further functional analyses confirmed that genetic factors related to estrogen play roles in several physiological processes, including immune function and cancer development. We found a novel genetic locus and developed a PRS for ELEE in East Asian women.</div></div><div><h3>Conclusion</h3><div>The results of this study could help to explain lifetime estrogen exposure and thereby to aid disease prevention.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108645"},"PeriodicalIF":3.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motoric cognitive risk syndrome and epigenetic aging in a cohort of the community-dwelling aging population","authors":"Xiaojun Zhang ,&nbsp;Chao Han ,&nbsp;Sha Zhu ,&nbsp;Lihua Tao ,&nbsp;Jagadish K. Chhetri ,&nbsp;Piu Chan","doi":"10.1016/j.maturitas.2025.108644","DOIUrl":"10.1016/j.maturitas.2025.108644","url":null,"abstract":"<div><h3>Background</h3><div>Preventing dementia is a global priority. Motoric cognitive risk (MCR) is a pre-dementia syndrome comprising age-related functional declines; however, there is little evidence of its association with accelerated aging.</div></div><div><h3>Objective</h3><div>To investigate the cross-sectional association between MCR and epigenetic aging using 13 DNA methylation (DNAm) clocks.</div></div><div><h3>Methods</h3><div>A total of 2949 participants from the Health and Retirement Study (HRS) cohort were included in this study. Of the 13 epigenetic clocks, nine were first-generation clocks and four were second-generation. The association between the prevalence of MCR and epigenetic aging clocks along with their accelerated aging (AccelAge) measures was calculated using logistic and linear regression models.</div></div><div><h3>Results</h3><div>The prevalence of MCR was 1.90 %; those with the syndrome had a mean age of 69.7 years. MCR was associated with Horvath 2, YANG, and GrimAge DNAm clocks in both logistic and linear regression models. Individuals with MCR had a higher rate of accelerated aging according to Horvath 2 AccelAge (OR = 1.37, 95 % CI = 1.02–1.85, <em>P</em> = 0.035), YANG AccelAge (OR = 1.29, 95 % CI = 1.03–1.62, <em>P</em> = 0.024) and GrimAge AccelAge (OR = 1.47, 95 % CI = 1.07–2.04, <em>P</em> = 0.019) in the logistic regression model, and Horvath 2 AccelAge (β = 0.34, 95 % CI = 0.04–0.64, <em>P</em> = 0.027), YANG AccelAge (β = 0.41, 95 % CI = 0.13–0.68, <em>P</em> = 0.003) and GrimAge AccelAge (β = 0.28, 95 % CI = 0.03–0.52, <em>P</em> = 0.025) in the linear regression model. A linear dose-response relationship with relative risk of MCR was observed in the multivariable-adjusted restricted cubic splines curves.</div></div><div><h3>Conclusion</h3><div>MCR was found to be a state of accelerated aging according to Horvath 2, YANG, and GrimAge DNAm clocks. Individuals with accelerated aging as measured by GrimAge had the highest odds of MCR. Epigenetic aging could serve as a marker for dementia risk in older individuals.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108644"},"PeriodicalIF":3.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between the use of oral contraceptives and intrauterine devices, and alcohol consumption in young Danish women","authors":"Emma Manthey Jakobsen ,&nbsp;Mohammad Zayeed Bin Alam ,&nbsp;Michael Winterdahl","doi":"10.1016/j.maturitas.2025.108643","DOIUrl":"10.1016/j.maturitas.2025.108643","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to identify potential differences in alcohol consumption and craving among users of combined oral contraceptives (COCs), intrauterine devices (IUDs), and naturally cycling (NC) women. Previous studies have often grouped COC and IUD users together, and so potentially overlooked behavioural differences between these two groups.</div></div><div><h3>Study design</h3><div>We conducted a cross-sectional observational study, collecting data from 101 Danish women aged 20–30 through a web-based survey.</div></div><div><h3>Main outcome measures</h3><div>Participants provided demographic information, details on use of hormonal contraceptives (HCs), menstrual history, and self-reported alcohol consumption. Additionally, the participants completed the Alcohol Use Disorders Identification Test (AUDIT) and the Alcohol Craving Questionnaire-Short Form-Revised (ACQ-SF-R).</div></div><div><h3>Results</h3><div>All participants reported alcohol consumption and were well matched in age, body mass index (BMI), and education. A higher proportion of IUD users were smokers, but the difference in smoking rates among the groups were not statistically significant. One-way ANOVA revealed significant differences in alcohol consumption among the groups, with IUD users consuming more alcohol than NC women and COC users. No significant differences in alcohol consumption were found between NC women and COC users. While there were trends towards higher AUDIT and ACQ-SF-R scores among IUD users, these differences did not reach statistical significance across the groups.</div></div><div><h3>Conclusion</h3><div>IUD users reported higher alcohol consumption than both COC users and NC women, while no substantial differences were observed between NC women and COC users. These findings provide valuable insights into the correlation between contraceptive methods and alcohol use. Although causality cannot be inferred, the results may aid healthcare professionals in developing tailored counselling strategies and identifying women who may be at increased risk of alcohol abuse.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108643"},"PeriodicalIF":3.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of self-reported endometriosis","authors":"Dereje G. Gete ,&nbsp;Annette J. Dobson ,&nbsp;Sally Mortlock ,&nbsp;Grant W. Montgomery ,&nbsp;Richard Hockey ,&nbsp;Jenny Doust ,&nbsp;Gita D. Mishra","doi":"10.1016/j.maturitas.2025.108642","DOIUrl":"10.1016/j.maturitas.2025.108642","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the validity and reliability of self-reported diagnoses of endometriosis.</div></div><div><h3>Study design</h3><div>The study included 8572 women from two Australian birth cohorts (1989–95 and 1973–78), using data from the Genetic variants, Early Life exposures, and Longitudinal Endometriosis Symptoms Study (GELLES), a sub-study of the Australian Longitudinal Study on Women's Health. Validity was assessed using predictive values, and reliability was evaluated with kappa statistics.</div></div><div><h3>Main outcome measures</h3><div>Self-reported endometriosis diagnoses from the GELLES question “Has a doctor or healthcare provider ever diagnosed you with endometriosis?” were validated using a longitudinal survey and linked administrative records as the gold standard.</div></div><div><h3>Results</h3><div>The findings from the 1989–95 and 1973–78 cohorts showed good agreement for overall self-reported endometriosis diagnosis, with uncorrected kappa values of 0.67 and 0.70 (or 0.86 and 0.83 after correction for bias and prevalence effects), and positive predictive values of 0.75 and 0.84, respectively. The agreement was notably stronger for self-reported surgical diagnoses, with uncorrected kappa values of 0.87 and 0.79, and positive predictive values of 0.84 and 0.85, respectively. However, the validity of clinically suspected diagnoses was lower due to the higher occurrence of discrepancies in case assignments.</div></div><div><h3>Conclusions</h3><div>The findings indicate that self-reported endometriosis obtained from two questions about diagnoses made by doctors and specified methods (surgical or clinical) are valid and reliable, particularly for surgical diagnoses. Women's responses to these questions can be reliable for identifying endometriosis cases in epidemiological research. Self-reported data of clinically suspected diagnoses (i.e. without surgical confirmation) should be interpreted cautiously.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108642"},"PeriodicalIF":3.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review on the relationship between menopausal hormone replacement therapy, sarcopenia, and sarcopenia-related parameters","authors":"Marc F. Österdahl ,&nbsp;Mary Ni Lochlainn ,&nbsp;Carly Welch ,&nbsp;Janice Rymer ,&nbsp;Mark Ashworth ,&nbsp;Julie Whitney ,&nbsp;Emma L. Duncan ,&nbsp;Claire J. Steves","doi":"10.1016/j.maturitas.2025.108609","DOIUrl":"10.1016/j.maturitas.2025.108609","url":null,"abstract":"<div><h3>Objective</h3><div>Whilst the beneficial effect of menopausal hormone replacement therapy (HRT) on osteoporosis is well established, its effect on sarcopenia is less clear. We conducted a systematic review of evidence exploring the relationship between HRT and sarcopenia.</div></div><div><h3>Methods</h3><div>We searched OVID Medline, Embase, CINAHL and Web of Science to 8 August 2024, identifying both in randomised controlled trials (RCTs) and observational studies of community-dwelling women. We excluded articles focussed on androgen therapy, or hormone therapy for indications other than menopause.</div><div>Our primary outcome was the effect of HRT upon sarcopenia defined by a consensus set of criteria (e.g. the definition proposed by the European Working Group on Sarcopenia in Older People 2). Grip strength, measures of physical performance, and radiological measures of muscle quantity were included as secondary outcomes. Reporting follows PRISMA guidelines.</div></div><div><h3>Results</h3><div>Searches identified 6090 articles, of which 43 were included in our final analysis. No studies used a consensus definition of sarcopenia. Most used data over 20 years old, with older formulations of HRT, though formulations were inconsistently reported.</div><div>Of the 15 RCTs included, two of six suggested a beneficial effect on grip strength, one of six on physical performance, and seven of 12 on radiologically assessed muscle quantity.</div><div>Of the 28 observational studies included, three of 11 suggested a beneficial effect on grip strength, two of seven on physical performance and three of 18 on radiologically assessed muscle quantity.</div><div>No studies reported detrimental effects on muscle. Risk of bias was high/severe. Observational models seldom adjusted for confounders.</div></div><div><h3>Conclusions</h3><div>No studies used modern consensus definitions of sarcopenia. For secondary outcomes, there was no consistent evidence of benefit, with methodological flaws, and outmoded HRT formulations.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108609"},"PeriodicalIF":3.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of motion sensor-based human activity recognition for supporting independence in smart homes","authors":"Moid Sandhu ,&nbsp;Marlien Varnfield ,&nbsp;Sanka Amadoru ,&nbsp;Paul A. Yates ,&nbsp;Brano Kusy ,&nbsp;David Silvera-Tawil","doi":"10.1016/j.maturitas.2025.108632","DOIUrl":"10.1016/j.maturitas.2025.108632","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the feasibility of leveraging Internet of Things (IoT) and artificial intelligence (AI) technologies to accurately identify key human activities critical for evaluating the ability of older adults to live independently.</div></div><div><h3>Methods</h3><div>Seventeen clinically relevant activities for assessing independent living of older adults were identified using standard clinical tools and insights from in-depth discussions with clinicians in geriatric care. Real-world data were then collected within a home environment using 20 IoT wearable and object sensors, as healthy adult participants performed each activity. A comprehensive set of features was extracted from the collected data, using both time and frequency domains, which were then used to develop a random forest machine learning algorithm to accurately recognize these activities.</div></div><div><h3>Results</h3><div>Data from 10 participants (7 male, 3 female) showed that the proposed algorithm achieved an average accuracy of 87.5 % in recognizing 17 key activities. Additionally, the algorithm achieved 97.95 % accuracy in identifying four functional areas namely mobility, hygiene, nutrition and hydration, and medication intake.</div></div><div><h3>Discussion</h3><div>These findings highlight the potential of IoT and AI-driven technologies to identify key activities essential for independent living in a home environment. The high accuracy of activity recognition enables reliable monitoring, offering valuable insights into the capabilities of older adults to live independently. This approach could be used to empower caregivers and clinicians to deliver timely, tailored care, fostering improved support and quality of life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108632"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Influence of gender and menopausal status on gut microbiota” [Maturitas Vol. 116 (2018) 43-53]","authors":"Jose A. Santos-Marcos ,&nbsp;Oriol A. Rangel-Zuñiga ,&nbsp;Rosa Jimenez-Lucena ,&nbsp;Gracia M. Quintana-Navarro ,&nbsp;Sonia Garcia-Carpintero ,&nbsp;Maria M. Malagon ,&nbsp;Blanca B. Landa ,&nbsp;Manuel Tena-Sempere ,&nbsp;Pablo Perez-Martinez ,&nbsp;Jose Lopez-Miranda ,&nbsp;Francisco Perez-Jimenez ,&nbsp;Antonio Camargo","doi":"10.1016/j.maturitas.2025.108641","DOIUrl":"10.1016/j.maturitas.2025.108641","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108641"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birth cohort differences in multimorbidity over time among Chinese oldest-old adults","authors":"Junmin Zhu ,&nbsp;Yafei Wu ,&nbsp;Siyu Duan ,&nbsp;Ya Fang","doi":"10.1016/j.maturitas.2025.108631","DOIUrl":"10.1016/j.maturitas.2025.108631","url":null,"abstract":"<div><h3>Background</h3><div>Multimorbidity imposes a significant burden on healthcare systems worldwide. Understanding longitudinal changes multimorbidity among the oldest-old (i.e., those aged 80 or more) is essential yet remains limited. This study investigated birth cohort differences in multimorbidity over time among Chinese oldest-old adults using two longitudinal surveys in different decades.</div></div><div><h3>Methods</h3><div>Data were drawn from the Chinese Longitudinal Healthy Longevity and Happy Family Study. 2703 and 2533 participants aged 80 or more were included in the 1998 and 2008 surveys, both with a one-decade follow-up, respectively. The multimorbidity count was assessed as the number of conditions an individual had from a list of 12 common chronic conditions. Generalized linear mixed models were employed to assess birth cohort differences, adjusting for demographic, lifestyle, and socioeconomic factors. Inverse probability weighting was applied to mitigate attrition bias.</div></div><div><h3>Results</h3><div>The 1998 survey (mean age: 89.32 ± 6.87 years, 51.17 % female) revealed no significant birth cohort differences in multimorbidity (<em>P</em> &gt; 0.05). In contrast, the 2008 survey (mean age: 91.12 ± 7.13 years, 59.97 % female) demonstrated that each successive birth cohort experienced a higher multimorbidity count than its predecessors (<em>P</em> &lt; 0.05). Compared to the cohort born in 1924–1928, participants from the cohort born in 1909–1913 had an estimated 0.217 fewer multimorbidity count (95 % CI: −0.397, −0.037), whereas those from the cohort born in 1919–1923 exhibited a reduction of 0.094 (95 % CI: −0.185, −0.002). Additionally, the multimorbidity count was significantly higher among smokers, alcohol consumers, and those with a lower intake of fresh fruit.</div></div><div><h3>Conclusion</h3><div>Multimorbidity is progressively increasing among recent birth cohorts among Chinese oldest-old adults. These findings highlight the urgent need for comprehensive policies and early interventions to promote healthy ageing.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108631"},"PeriodicalIF":3.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}