Maturitas最新文献

{"title":"Diabetes is associated with impaired skeletal muscle quality, not quantity, in older adults, based on CT-derived chest muscle metrics","authors":"Li Zhang ,&nbsp;Huazheng Shi ,&nbsp;Bixia Shen ,&nbsp;Jun Tao ,&nbsp;Youyi Tu ,&nbsp;Xiaoyan Zhang","doi":"10.1016/j.maturitas.2025.108710","DOIUrl":"10.1016/j.maturitas.2025.108710","url":null,"abstract":"<div><h3>Objective</h3><div>The study assessed the association between diabetes and both the quantity and quality of skeletal muscle among older adults, based on an analysis of chest computed tomography (CT) scans.</div></div><div><h3>Methods</h3><div>In this cross-sectional study of 1225 adults aged 65 years or more, 255 had type 2 diabetes mellitus. All participants had chest CT scans. Skeletal muscle index and skeletal muscle density at the level of the fourth thoracic vertebra were assessed using SliceOmatic software.</div></div><div><h3>Results</h3><div>Skeletal muscle density at the fourth thoracic level was significantly lower in the diabetes group, while no significant difference between groups was observed in the muscle index. Spearman correlation analysis showed no significant correlation between fasting plasma glucose or glycated hemoglobin and the muscle index. However, both fasting plasma glucose and glycated hemoglobin were negatively correlated with skeletal muscle density (rho = −0.100 and −0.194, respectively; both P &lt; 0.05). After adjusting for potential confounders, linear regression analysis indicated that diabetes was negatively associated with skeletal muscle density (β = −0.069, P = 0.002). Logistic regression analysis identified skeletal muscle density as a significant independent factor associated with diabetes (OR = 0.943, 95 % confidence interval 0.908–0.979, P = 0.002).</div></div><div><h3>Conclusion</h3><div>Based on chest CT scan, diabetes exerts a discernible impact on the quality of skeletal muscle (skeletal muscle density) at the fourth thoracic level among older adults, rather than its quantity (skeletal muscle index). These insights can inform clinical interventions and disease management strategies.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108710"},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of intrinsic capacity in predicting cancer mortality – Evidence from the UK Biobank","authors":"Joaquín Calatayud ,&nbsp;Rodrigo Núñez-Cortés ,&nbsp;Rubén López-Bueno ,&nbsp;Mikel Izquierdo ,&nbsp;Robinson Ramírez-Vélez","doi":"10.1016/j.maturitas.2025.108709","DOIUrl":"10.1016/j.maturitas.2025.108709","url":null,"abstract":"<div><h3>Aim</h3><div>To examine the association between intrinsic capacity and cancer mortality in middle-aged and older adults.</div></div><div><h3>Methods</h3><div>We analysed a prospective cohort of 443,130 participants from the UK Biobank, with seven biomarkers reflecting the level of functioning in five domains of intrinsic capacity to calculate an overall score (ranging from 0 [better] to +4 [poor]). Associations between intrinsic capacity scores and mortality from any type of cancer (censored as of December 31, 2022) were estimated using Cox proportional hazard models adjusted for multiple potential confounders.</div></div><div><h3>Results</h3><div>During a median follow-up of 10.6 years (interquartile range [IQR] 10.0, 11.3), 13,483 deaths were attributed to all cancers. In the full sample, the adjusted model showed that higher intrinsic capacity (<em>i.e.</em> a score of +4) was associated with a significant increase in cancer mortality (mean hazard ratio [HR] 1.20, 95 % CI 1.06–1.35, in men [C-index = 0.72] and 1.29, 1.14–1.46, in women [C-index = 0.69]). Subgroup analyses stratified by age and sex revealed larger effect sizes among (1) White participants compared with other ethnic groups, (2) individuals with higher socioeconomic deprivation, (3) current/former smokers, (4) frequent alcohol consumers, (5) those with a body mass index &gt;25 kg/m², and (6) individuals reporting no or low physical activity.</div></div><div><h3>Conclusion</h3><div>Intrinsic capacity serves as a valuable predictor of cancer mortality, with deficits strongly associated with increased mortality risk in both middle-aged and older adults. Clinicians should recognise that even the presence of only two deficits in intrinsic capacity can significantly elevate the risk of cancer mortality.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108709"},"PeriodicalIF":3.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and life-course physical activity in community-dwelling older people","authors":"Daisuke Kakita ,&nbsp;Kenji Harada ,&nbsp;Satoshi Kurita ,&nbsp;Masanori Morikawa ,&nbsp;Chiharu Nishijima ,&nbsp;Kazuya Fujii ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.maturitas.2025.108698","DOIUrl":"10.1016/j.maturitas.2025.108698","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity is a modifiable factor for sarcopenia. Although several studies have suggested the importance of physical activity in preventing sarcopenia, it is unclear whether different levels of physical activity across different life stages influence sarcopenia. This study examined the association between life-course physical activity and sarcopenia.</div></div><div><h3>Methods</h3><div>In total, 3846 participants (mean age 76.1 ± 4.6 years, 53.3 % female) from the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes, a national cohort study conducted in Japan, were included in the analysis. Physical activity status across life stages was categorized as follows: Non-exercisers, <em>n</em> = 2070 (53.8 %); Past exercisers, <em>n</em> = 502 (13.1 %); New exercisers, <em>n</em> = 722 (18.8 %); Maintainers, <em>n</em> = 371 (9.7 %); and Others, <em>n</em> = 181 (4.7 %).</div></div><div><h3>Results</h3><div>Binary logistic regression analysis showed that Maintainers (odds ratio [OR]: 0.58, 95 % confidence interval [CI]: 0.42–0.80, <em>p</em> = 0.001) had significantly lower odds of sarcopenia in old age than Non-exercisers, even after adjustment for covariates. However, this was not the case for New exercisers (OR: 0.83, 95 % CI: 0.67–1.04, <em>p</em> = 0.099), Past exercisers (OR: 0.87, 95 % CI: 0.67–1.13, <em>p</em> = 0.296); and Others (OR: 0.80; 95 % CI: 0.54–1.21, <em>p</em> = 0.291).</div></div><div><h3>Conclusions</h3><div>Lifelong exercise habits were associated with lower odds of sarcopenia in older age. In contrast, discontinuation of physical activity in mid-life or late life showed no advantage over lifelong inactivity. However, due to the cross-sectional design of this study, causal relationships cannot be established.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108698"},"PeriodicalIF":3.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of fetal/infant and adolescent exposure to famine on age at menopause in Chinese women","authors":"Haomin Wang ,&nbsp;Huamei Ju ,&nbsp;Shu Zhang ,&nbsp;Haojie Li ,&nbsp;Xia Chen","doi":"10.1016/j.maturitas.2025.108697","DOIUrl":"10.1016/j.maturitas.2025.108697","url":null,"abstract":"<div><h3>Background</h3><div>Early-life nutritional deprivation may influence lifelong health, but its role in the broader process of reproductive aging remains underexplored. Guided by the Developmental Origins of Health and Disease framework, this study investigates the impacts of fetal/infant and adolescent exposure to famine on age at natural menopause, a key indicator of reproductive aging.</div></div><div><h3>Methods</h3><div>The study sample comprised 4256 women from the China Health and Retirement Longitudinal Study. Participants were categorized into fetal/infant (1959–1962 births) or adolescent (1942–1946 births) famine-exposed cohorts and non-exposed controls. Multivariable linear and logistic regression models were used to assess associations between famine exposure and age at natural menopause or early menopause, adjusting for sociodemographic, economic, and behavioral covariates.</div></div><div><h3>Results</h3><div>Famine exposure was associated with an earlier age at natural menopause: 1.16 years earlier for fetal/infant exposure (β = −0.12, <em>p</em> = 0.002), and 0.72 years earlier for adolescent exposure (β = −0.07, <em>p</em> = 0.014); it was also associated with increased odds of early menopause (odds ratio [OR] = 1.05, 95 % confidence interval [CI] 1.01–1.10). No significant association with premature menopause was observed.</div></div><div><h3>Conclusion</h3><div>Nutritional deprivation during critical developmental windows—particularly adolescence—has distinct, long-term effects on the trajectory of reproductive aging. These observational findings, which cannot establish causality, underscore the importance of early-life nutrition in shaping female reproductive health and are consistent with the Developmental Origins of Health and Disease framework in reproductive health.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108697"},"PeriodicalIF":3.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause and risk of atherosclerotic cardiovascular disease: insights from a women's UK Biobank cohort","authors":"Alexandre Vallée","doi":"10.1016/j.maturitas.2025.108693","DOIUrl":"10.1016/j.maturitas.2025.108693","url":null,"abstract":"<div><h3>Background</h3><div>Menopause induces hormonal and metabolic changes that may increase the risk of atherosclerotic cardiovascular disease (ASCVD). However, the contribution of menopause to ASCVD risk, beyond aging, remains debated. This study investigated the association between menopause and ASCVD risk in a large population-based cohort.</div></div><div><h3>Methods</h3><div>We analyzed data from 222,007 women in the UK Biobank, excluding those with prior cardiovascular disease or uncertain menopausal status. ASCVD risk was estimated using pooled cohort equations. High ASCVD risk was defined as a 10-year risk ≥7.5 %. To address missing data, multiple imputations for the Area Deprivation Index (ADI) were performed using a fully conditional specification approach. Multivariable regression models were used to assess the association between menopause and ASCVD risk, adjusting for age as well as socioeconomic, lifestyle, metabolic, and clinical factors.</div></div><div><h3>Results</h3><div>Postmenopausal women (n = 158,572) had significantly higher estimated ASCVD risk than premenopausal women (n = 63,435) (3.75 % vs. 0.81 %; p &lt; 0.001). The prevalence of high ASCVD risk was 9.65 % in postmenopausal women versus 0.41 % in premenopausal women (p &lt; 0.001). After full adjustment, menopause was independently associated with a higher ASCVD risk (β = 0.56 %; 95 % CI 0.54–0.58) and an 18 % increased likelihood of high ASCVD risk (OR = 1.18; 95 % CI 1.01–1.37). The association was strongest among women aged under 60 years, with no significant association observed beyond 60 years.</div></div><div><h3>Conclusion</h3><div>Menopause is independently associated with increased ASCVD risk, particularly in women aged under 60 years. These findings highlight the importance of considering menopausal status in cardiovascular risk assessment and implementing targeted prevention strategies in midlife women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108693"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and circadian syndrome in middle-aged and older adults: A multi-method analysis of a national sample","authors":"Xue Wang ,&nbsp;Huaxin Si ,&nbsp;Yanyan Li ,&nbsp;Jiaqi Yu ,&nbsp;Wendie Zhou ,&nbsp;Hejing Chen ,&nbsp;Cuili Wang","doi":"10.1016/j.maturitas.2025.108695","DOIUrl":"10.1016/j.maturitas.2025.108695","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence underscores the link between adverse childhood experiences (ACEs) and poor health across the lifespan.</div></div><div><h3>Methods</h3><div>Latent class analysis was used to identify distinct classes of ACEs. Generalized linear regression and binary logistic regression were employed to assess the associations between ACEs and circadian syndrome (CircS). Additionally, network analysis was conducted to identify central nodes.</div></div><div><h3>Results</h3><div>The study had a total of 7896 participants. The latent class analysis identified three classes of ACEs, namely class 1 ‘household mental illness’, class 2 ‘physical abuse and bullying’, and class 3 ‘low ACEs’. Significant associations with CircS were observed for higher cumulative ACE exposure, including total ACEs (OR = 1.08), 3 ACEs (OR = 1.28), ≥4 ACEs (OR = 1.60), total threat-related ACEs (OR = 1.10), and ≥ 2 threat-related ACEs (OR = 1.32). The class 2 cluster, marked by ‘physical abuse and bullying’, was associated with increased CircS (OR = 1.22). Similarly, individual ACEs—household violence, household mental illness, and parental separation/divorce—were linked to higher risk of CircS (OR = 1.26–2.69). These exposures were also associated with a larger number of CircS components (β = 0.05–0.28). Network analysis further highlighted household mental illness, household violence, bullying, and physical abuse as the most central nodes.</div></div><div><h3>Conclusions</h3><div>This study provides a comprehensive framework for understanding the effects of ACEs and underscores the importance of screening for them to better address their associations with circadian health.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108695"},"PeriodicalIF":3.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased and sustained physical activity in postmenopausal women: 2-year follow-up of a resistance training intervention","authors":"Moa Henriksson ,&nbsp;Sigrid Nilsson ,&nbsp;Emilia Berin ,&nbsp;Mats Hammar ,&nbsp;Anna-Clara Spetz Holm ,&nbsp;Hanna Lindblom","doi":"10.1016/j.maturitas.2025.108696","DOIUrl":"10.1016/j.maturitas.2025.108696","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess whether levels of physical activity can be modified and sustained for 2 years in postmenopausal women with initially low physical activity levels participating in a randomised controlled trial.</div></div><div><h3>Study design</h3><div>Postmenopausal women with vasomotor symptoms and low activity levels were randomised to a 15-week supervised full-body resistance training program three times/week or a control group maintaining low activity. After the intervention, controls were offered an introductory resistance training session and 15-week gym membership. Both groups received informative and encouraging emails every six months during 2-year follow-up.</div></div><div><h3>Main outcome</h3><div>Change in level of physical activity.</div></div><div><h3>Measures</h3><div>Physical activity was assessed via the International Physical Activity Questionnaire short form (IPAQ) at baseline, 15 weeks, six months, and two years. Data were analysed with Wilcoxon's signed rank, Friedman, and Mann-Whitney <em>U</em> tests.</div></div><div><h3>Results</h3><div>Of 65 women randomised, 58 (89 %) completed the 2-year follow-up study. At baseline, 21 in the intervention and 15 in the control group were inactive according to IPAQ scores. After two years, this was reduced to four in each group (14 % and 16 %, respectively). Both groups significantly increased moderate to vigorous activity from baseline to two years (intervention group: median 0 to 180 min, <em>p</em> &lt; 0.001; control group: median 0 to 125 min, <em>p</em> = 0.004).</div></div><div><h3>Conclusions</h3><div>Both groups significantly increased their level of physical activity (intervention group during the 15-week intervention, control group between 15-week and 6-month follow-ups) and maintained this for two years. A resistance training session, gym membership, training diary, and supportive emails form a feasible strategy to improve physical activity among postmenopausal women with low activity levels.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"202 ","pages":"Article 108696"},"PeriodicalIF":3.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dry eye symptoms in midlife women: A cross-sectional analysis of prevalence, risk factors, and quality-of-life outcomes","authors":"Sakda Arj-Ong Vallibhakara ,&nbsp;Kitti Chattrakulchai ,&nbsp;Orawin Vallibhakara ,&nbsp;Makaramas Anantaburana ,&nbsp;Sarayut Nijvipakul","doi":"10.1016/j.maturitas.2025.108694","DOIUrl":"10.1016/j.maturitas.2025.108694","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the prevalence, associated factors, and quality-of-life impact of dry eye symptoms among perimenopausal and postmenopausal women in Thailand.</div></div><div><h3>Study Design</h3><div>This cross-sectional study, conducted from September to December 2024, included 262 women aged 41–60 years attending a gynaecology and menopause clinic at Ramathibodi Hospital. Participants completed the Ocular Surface Disease Index and the Menopause-Specific Quality of Life questionnaires. Multivariate logistic regression was used to identify factors associated with moderate to severe symptoms.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was the prevalence of dry eye symptoms. Secondary outcomes included symptom severity, quality-of-life scores, and occupational or clinical risk factors for moderate to severe symptoms.</div></div><div><h3>Results</h3><div>Dry eye symptoms were identified in 64.9 % of participants, with comparable rates in perimenopausal (61.7 %) and postmenopausal (68.2 %) women. No significant difference in symptom scores was observed between groups (<em>p</em> = 0.746). Computer-based work was independently associated with moderate to severe symptoms (adjusted odds ratio 1.81, 95 % CI 1.10–2.99). Women with more severe symptoms reported significantly poorer physical, psychological, and vasomotor quality-of-life scores.</div></div><div><h3>Conclusions</h3><div>Dry eye symptoms are highly prevalent among midlife Thai women and negatively affect quality of life, particularly in the physical, psychological, and vasomotor domains. Occupational screen exposure is a significant modifiable risk factor. Early screening and targeted management may help reduce the impact of symptoms during the menopausal transition.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108694"},"PeriodicalIF":3.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the genetic architecture of early menopause in the Tehran cardiometabolic genetic study","authors":"Leila Najd-Hassan-Bonab ,&nbsp;Farzaneh Motafeghi ,&nbsp;Maryam Moazzam-jazi ,&nbsp;Maryam Farahmand ,&nbsp;Fereidoon Azizi ,&nbsp;Maryam S. Daneshpour ,&nbsp;Fahimeh Ramezani Tehrani","doi":"10.1016/j.maturitas.2025.108692","DOIUrl":"10.1016/j.maturitas.2025.108692","url":null,"abstract":"<div><h3>Background</h3><div>Population studies elucidating the genetic architecture of early menopause have mainly focused on European ancestries, leaving a gap in understanding of the genetic influences in non-European populations. This study seeks to identify potential genetic variants linked to early menopause in Iranian women.</div></div><div><h3>Research design and methods</h3><div>We conducted a genome-wide association study on early menopause involving a discovery group of 3421 women, comprising 3145 individuals with normal age at menopause and 276 with early menopause. Additionally, a confirmation group included 1015 women, consisting of 208 individuals with a poor ovarian reserve and 807 with normal ovarian reserve, all drawn from an Iranian cohort. We analyzed over 9 million variants using the Genome-wide Complex Trait Analysis tool, followed by thorough bioinformatics evaluations and functional annotations.</div></div><div><h3>Results</h3><div>We identified specific genetic variants associated with early menopause, notably the rs9943588 variant of the GALNT18 gene; the variant significantly increases the risk of early menopause [OR = 1.93; <em>p</em> = 2.54E-8]. In our confirmatory population, this variant was associated with a 35 % increased risk of poor ovarian reserve (OR = 1.35, <em>p</em> &lt; 0.0001). Furthermore, epigenomics data suggest that rs9943588 may influence a regulatory motif for the ETS transcription factor in women.</div></div><div><h3>Conclusions</h3><div>The rs9943588 variant of the GALNT18 gene is associated with an elevated risk of early menopause among Iranian women. Moreover, our results show significant differences in allele frequencies between Iranian and European variants, emphasizing the advantages and challenges of large-scale trans-ethnic strategies to inform personalized approaches to women's health.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108692"},"PeriodicalIF":3.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of resistance training on glycemic control, cardiometabolic health, and body composition in middle-aged and older women with type 2 diabetes and overweight or obesity: A systematic review and meta-analysis","authors":"Ruojiang Liu ,&nbsp;Xiaofeng Shi ,&nbsp;Xiang Zhang","doi":"10.1016/j.maturitas.2025.108691","DOIUrl":"10.1016/j.maturitas.2025.108691","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the effects of resistance training on glycemic control, cardiometabolic markers, and body composition in women with overweight or obesity who are middle-aged or older and have type 2 diabetes mellitus.</div></div><div><h3>Methods</h3><div>Following the guidelines on Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we searched CINAHL, PubMed, MEDLINE, and EMBASE for randomized controlled trials published in English up to May 2025. Eligible studies included resistance training interventions for women with a body mass index of 25 kg/m² or more and type 2 diabetes, with a mean participant age of 45 years or older. Random-effects meta-analyses were conducted using Review Manager software, with subgroup analyses to address heterogeneity.</div></div><div><h3>Results</h3><div>Thirteen trials with a total of 315 participants were included. Resistance training significantly reduced fasting glucose (mean difference − 20.70 mg per deciliter, 95 % CI -33.65 to −7.75, <em>p</em> = 0.002), glycated hemoglobin (mean difference −0.66 %, 95 % CI −1.01 to −0.33, <em>p</em> = 0.0002), total cholesterol, low-density lipoprotein cholesterol, diastolic blood pressure, body mass index, and body fat percentage. No significant effects were observed for triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, or body weight. Greater reductions in fasting glucose were observed with training intensity above 70 % of one-repetition maximum.</div></div><div><h3>Conclusions</h3><div>Resistance training is effective in improving glycemic control, certain cardiometabolic risk factors, and body composition in this population. These findings support its role as a targeted intervention and highlight the need for further research to refine its application.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"201 ","pages":"Article 108691"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}