Maturitas最新文献

{"title":"Sex-specific associations of neurodegeneration and inflammatory biomarkers with intrinsic capacity in older adults: Findings from the 4-year longitudinal Multidomain Alzheimer's Prevention Trial (MAPT)","authors":"Luana Caroline de Assunção Cortez Corrêa ,&nbsp;Jérémy Raffin ,&nbsp;Bruno Vellas ,&nbsp;Ricardo Oliveira Guerra ,&nbsp;Philipe de Souto Barreto","doi":"10.1016/j.maturitas.2024.108191","DOIUrl":"10.1016/j.maturitas.2024.108191","url":null,"abstract":"<div><div>This four-year longitudinal study investigated whether the cross-sectional and longitudinal associations of inflammation-related and neurodegenerative-related blood biomarkers with intrinsic capacity differ according to sex. The sample comprised 1117 older adults (&lt;70 years, 63.8 % females) from the Multidomain Alzheimer's Prevention Trial (MAPT). The domains of intrinsic capacity were operationalized as cognition (Mini-Mental State Examination), locomotion (Short Physical Performance Battery), vitality (Handgrip Strength), and psychological well-being (Geriatric Depression Scale), each scaled from 0 (worst intrinsic capacity possible) to 100 (best intrinsic capacity possible). Plasma biomarkers included interleukin 6 (picograms per milliliter), growth differentiation factor-15 (picograms per milliliter), tumor necrosis factor receptor 1 (picograms per milliliter), neurofilament light chain (picograms per milliliter), progranulin (nanograms per milliliter), and amyloid-beta ratio. Linear mixed models were analyzed to examine whether sex modified the cross-sectional and longitudinal association between biomarkers and intrinsic capacity. No significant interaction effect was observed at baseline. Longitudinal analyses revealed a significant interaction between sex and interleukin 6 (p = .005), such that higher levels of interleukin 6 tended to be associated with a faster decline in intrinsic capacity for males (B = −0.385; p = .055; 95 % CI = −0.778; 0.008) but not for females (B = 0.287; p = .041; 95 % CI = 0.011; 0.563). The other biomarkers had no sex-dependent associations with intrinsic capacity. A potential sex-dependent effect of the inflammatory status on intrinsic capacity must be further investigated.</div><div>Clinical trial registration with <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> <span><span>NCT00672685</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108191"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy","authors":"Marla Shapiro C.M. ,&nbsp;Xi Wu ,&nbsp;Xuegong Wang ,&nbsp;Kentaro Miyazaki ,&nbsp;Antonia Morga ,&nbsp;Rossella E. Nappi ,&nbsp;Petra Stute ,&nbsp;Karla Martins ,&nbsp;Katrin Schaudig","doi":"10.1016/j.maturitas.2024.108159","DOIUrl":"10.1016/j.maturitas.2024.108159","url":null,"abstract":"<div><h3>Objective</h3><div>To report patient-reported quality-of-life (QOL) outcomes in the DAYLIGHT study.</div></div><div><h3>Study design</h3><div>DAYLIGHT was a phase 3b, randomized, double-blind, 24-week, placebo-controlled study. Participants were women aged ≥40 to ≤65 years with moderate to severe vasomotor symptoms (VMS) considered unsuitable for hormone therapy (HT) (contraindications, caution, stoppers, or averse) randomized 1:1 to placebo or fezolinetant 45 mg once daily.</div></div><div><h3>Main outcome measures</h3><div>Primary endpoint: mean change in daily VMS frequency of moderate to severe episodes from baseline to week 24. Secondary: patient-reported sleep disturbance (PROMIS SD SF 8b). Exploratory: patient-reported sleep disturbance (Patient Global Impression of Severity/Change in Sleep Disturbance [PGI-S/PGI-C SD]), menopause and VMS-related QOL (Female Sexual Function Index [FSFI], Menopause-Specific Quality of Life [MENQOL], Patient Global Impression of Change in Vasomotor Symptoms [PGI-C VMS], Work Productivity and Activity Impairment questionnaire specific to VMS [WPAI-VMS]), and general QOL (European Quality of Life 5 Dimensions 5 Level Version [EQ-5D-5L], Patient Health Questionnaire for Anxiety and Depression [PHQ-4]).</div></div><div><h3>Results</h3><div>Overall, 452 women received at least one dose of study drug (placebo <em>n</em> = 226; fezolinetant <em>n</em> = 226): HT contraindicated (50; 11 %), caution (165; 37 %), stoppers (69; 15 %), and averse (168; 37 %). DAYLIGHT results showed statistically significant reductions in VMS frequency/severity in the fezolinetant group versus placebo at week 24. Week 24 improvements were seen in the fezolinetant group versus placebo in: PROMIS SD SF 8b total score (least squares [LS] mean difference: −2.5; 95 % CI: −3.9, −1.1; <em>p</em> &lt; 0.001), MENQOL total score (LS mean difference: −0.44; 95 % CI: −0.69, −0.18; <em>p</em> &lt; 0.001), and WPAI-VMS (activity impairment [<em>p</em> &lt; 0.001], overall work productivity loss [<em>p</em> = 0.036], and presenteeism [<em>p</em> = 0.002] domains). A higher proportion of participants in the fezolinetant group reported positive changes in sleep disturbance (PGI-C SD, <em>p</em> &lt; 0.001), sleep disturbance severity (PGI-S SD, <em>p</em> = 0.042), and VMS (PGI-C VMS, <em>p</em> &lt; 0.001) versus placebo.</div></div><div><h3>Conclusions</h3><div>Patient-reported outcomes demonstrate that reductions in VMS frequency with fezolinetant treatment were associated with improvements in QOL.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108159"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary variety and the relationship between polypharmacy and incident disability among Japanese community-dwelling older adults: A longitudinal study","authors":"Chiharu Nishijima ,&nbsp;Kenji Harada ,&nbsp;Satoshi Kurita ,&nbsp;Masanori Morikawa ,&nbsp;Kazuya Fujii ,&nbsp;Daisuke Kakita ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.maturitas.2024.108184","DOIUrl":"10.1016/j.maturitas.2024.108184","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examined the association between polypharmacy and incident disability across the dietary variety score (DVS) strata among community-dwelling older adults.</div></div><div><h3>Study design</h3><div>A prospective cohort study with community-dwelling adults aged ≥65 in Aichi, Japan.</div></div><div><h3>Main outcome measures</h3><div>Polypharmacy was defined as ≥5 concomitant prescription drugs per day. Participants were classified as having non-polypharmacy or polypharmacy and a lower, moderate, or high DVS. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95 % confidence intervals (CIs) for incident disability among the polypharmacy groups after adjusting for potentially confounding variables.</div></div><div><h3>Results</h3><div>The analysis included 5254 older adults (55.7 % female; average age 74.0 ± 5.5 years) with a mean follow-up time of 34.7 ± 5.9 months. Among them, 4842 remained disability-free, while 412 (7.8 %) developed a disability during follow-up. The potential confounder-adjusted disability HR for participants in the polypharmacy group was 1.37 (CI: 1.07–1.75; p = 0.011). In the stratified analyses, polypharmacy in the lower DVS group was significantly associated with higher HRs for incident disability (1.62 [1.11–2.37; p = 0.013]), and no significant association between polypharmacy and incident disability was observed in the higher DVS group (1.12 [0.74–1.71; p = 0.590]).</div></div><div><h3>Conclusions</h3><div>Polypharmacy was positively associated with disability incidence, with a more pronounced effect in participants with a lower DVS. Polypharmacy patients may have different reasons for not being able to have a higher variety diet from non-polypharmacy people.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108184"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at menarche in relation to risk of chronic obstructive pulmonary disease: Results from the China Kadoorie Biobank study of 300,000 Chinese women","authors":"Sha Huang ,&nbsp;Siyu Zou ,&nbsp;Ruofan Gongye ,&nbsp;Shunqing Xu","doi":"10.1016/j.maturitas.2024.108173","DOIUrl":"10.1016/j.maturitas.2024.108173","url":null,"abstract":"<div><h3>Background</h3><div>Age at menarche has important implications for lung function. However, little is known about its association with chronic obstructive pulmonary disease (COPD). The present study aims to investigate age at menarche in relation to the risk of COPD among Chinese women.</div></div><div><h3>Methods</h3><div>We analyzed data on 302,463 women aged 30–79 years from 10 regions across China during 2004 to 2008, recruited by the China Kadoorie Biobank baseline survey. Multivariable logistic regression was used to examine odds ratios (ORs) with 95 % confidence intervals (CIs) for the association between COPD and age at menarche.</div></div><div><h3>Results</h3><div>Overall, the average age at menarche was 15.4 ± 2.0 years. The relationship between age at menarche and adult COPD was J-shaped. Compared with women with menarche at age 13–14 years, the adjusted ORs for COPD for menarche at ≤12, 15–16, and ≥ 17 years of age were 1.21 (95 % CI: 1.07, 1.36), 1.04 (95 % CI: 0.98, 1.11) and 1.11 (95 % CI, 1.03, 1.19), respectively. The patterns of association appeared to be more pronounced among women living in rural areas and those who ever drank alcohol.</div></div><div><h3>Conclusions</h3><div>In Chinese adults, both early menarche and late menarche are associated with increased risk of COPD; as such, age at menarche may be a factor that could help to identify women at higher COPD risk who would benefit from early preventative strategies.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108173"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long working hours and depression: Gender and age effect?","authors":"Alexis Descatha ,&nbsp;Grace Sembajwe ,&nbsp;Marc Fadel","doi":"10.1016/j.maturitas.2025.108194","DOIUrl":"10.1016/j.maturitas.2025.108194","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108194"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt added at the table, APOE genotype and incident dementia","authors":"Jiao-Jiao Ren ,&nbsp;Zhi-Hao Li ,&nbsp;Wen-Fang Zhong ,&nbsp;Pei-Liang Chen ,&nbsp;Xiao-Meng Wang ,&nbsp;Wei-Qi Song ,&nbsp;Chen Mao","doi":"10.1016/j.maturitas.2024.108183","DOIUrl":"10.1016/j.maturitas.2024.108183","url":null,"abstract":"<div><h3>Background</h3><div>The frequency of salt added at the table (i.e., to food after it has been prepared, during consumption) could reflect an individual's long-term dietary preference and habitual intake in Western countries. However, little is known about the association between the frequency of salt added at the table and incident dementia. This study investigates the association of the frequency of salt added at the table with the risk of dementia and explores differences in the associations among people with apolipoprotein E ε4 genotypes.</div></div><div><h3>Methods</h3><div>Individuals indicated whether they added salt to their food at the table (salt used for cooking was not included) “never/rarely”, “sometimes”, “usually”, or “always”. Cox proportional hazards models were used to compute hazard ratios with 95 % confidence intervals and evaluate the association between the frequency of salt added at the table and incident dementia.</div></div><div><h3>Results</h3><div>We observed a graded relation between the frequency of salt added at the table and spot urine sodium concentrations and estimated 24-h sodium excretion. Over a median follow-up of 13.7 years, there were 9373 cases of all-cause dementia, including 4119 of Alzheimer's disease and 2052 of vascular dementia. With a higher frequency of salt added at the table, the risk of all-cause dementia, Alzheimer's disease and vascular dementia increased in a monotonic manner after adjustment for potential confounding factors (all P-trend &lt;0.001). These associations of the frequency of salt added at the table with the risks of all-cause dementia, Alzheimer's disease and vascular dementia were greater in apolipoprotein E ε4 heterozygotes and homozygotes.</div></div><div><h3>Conclusion</h3><div>Our study showed that a higher frequency of salt added at the table was associated with a higher risk of incident dementia. This positive association was more prominent among individuals with apolipoprotein E ε4 heterozygotes and homozygotes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108183"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the association between long working hours and the onset of depressive symptoms in middle-aged and older workers in Korea: A population-based longitudinal study (2006–2022)","authors":"Seong-Uk Baek ,&nbsp;Yu-Min Lee ,&nbsp;Jong-Uk Won ,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.maturitas.2024.108175","DOIUrl":"10.1016/j.maturitas.2024.108175","url":null,"abstract":"<div><h3>Background</h3><div>Korean society is projected to undergo a rapid aging of its workforce. We explored gender differences in the association between working hours and the onset of depressive symptoms among middle-aged and older workers.</div></div><div><h3>Study design</h3><div>This study included workers aged ≥45 years from a nationwide panel study with biennial follow-ups (<em>n</em> = 4941, observations = 18,531). Weekly working hours were self-reported. We employed generalized estimating equations with log link function to explore the association between working hours and the onset of depressive symptoms at the two-year follow-up.</div></div><div><h3>Main outcome measures</h3><div>The 10-item version of the Center for Epidemiologic Studies Depression Scale.</div></div><div><h3>Results</h3><div>The incidence of onset of depressive symptoms was 10.7 % among those working 35–40 h/week and 13.0 % among those working ≥55 h/week. In the overall sample, those working ≥55 h/week had increased risk of the onset of depressive symptoms at the two-year follow-up (risk ratio: 1.12, 95 % confidence interval: 1.01–1.24). There was a positive interaction between being female and working ≥55 h/week in their effect on the risk of onset depressive symptom (<em>P</em> = 0.010). In the gender-stratified analysis, working ≥55 h/week was associated with an increased risk of the onset of depressive symptoms at the two-year follow-up among women (risk ratio: 1.29, 95 % confidence interval: 1.08–1.53); however, we observed no clear associations among men.</div></div><div><h3>Conclusion</h3><div>Long working hours are positively associated with the of onset depressive symptoms in middle-aged and older workers, and this association is pronounced among women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108175"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bio-psycho-social investigation of menopause transition and job satisfaction","authors":"Carol Atkinson ,&nbsp;Fiona Carmichael ,&nbsp;Jo Duberley","doi":"10.1016/j.maturitas.2024.108187","DOIUrl":"10.1016/j.maturitas.2024.108187","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the implications of menopause transition for job satisfaction within a framework that integrates bio-psycho-social factors and effects.</div></div><div><h3>Study design</h3><div>The study analyses quantitative and qualitative data from a survey of 1684 women in three UK police forces, where growing numbers work during menopause transition within what has been termed a hyper-masculine culture.</div></div><div><h3>Results</h3><div>We evidence that job satisfaction is negatively impacted by experience of menopause symptoms. Attitudes towards age and menopause are also important: job satisfaction is lower for peri- and post-menopausal women with negative attitudes and higher for women with more positive and open attitudes. Some workplace factors such as shift working and the gender balance of the workplace also have a significant impact on the job satisfaction of women transitioning menopause.</div></div><div><h3>Conclusion</h3><div>Our results highlight the need for human resource practices that go beyond the typical focus on symptoms. Support mechanisms need to address attitudes towards menopause and develop more inclusive workplaces in order to maintain women's job satisfaction and retain them in the workplace during menopause transition.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108187"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being underweight or obese in adolescence may increase the risk of female infertility later in life: The Japan Nurses' Health Study","authors":"Miho Iida ,&nbsp;Yuki Ideno ,&nbsp;Kazue Nagai ,&nbsp;Yukiko Miyazaki ,&nbsp;Ryota Toki ,&nbsp;Yasunori Sato ,&nbsp;Takeshi Iwasa ,&nbsp;Naoko Arata ,&nbsp;Takumi Kurabayashi ,&nbsp;Kunihiko Hayashi","doi":"10.1016/j.maturitas.2024.108172","DOIUrl":"10.1016/j.maturitas.2024.108172","url":null,"abstract":"<div><h3>Objectives</h3><div>Underweight or obesity is associated with infertility in women, but large cohort studies with a life course perspective are rare. We explored the association between body mass index (BMI) at age 18 and subsequent infertility among Japanese women.</div></div><div><h3>Study design</h3><div>In total, 15,907 married women aged 30–44 years who participated in a prospective cohort baseline survey during 2001–2007 were cross-sectionally analyzed. Those with a history of cancer, and those with a partner with infertility or missing data were excluded. All data were obtained from self-reported questionnaires.</div></div><div><h3>Main outcome measures</h3><div>The main outcome measure was infertility, defined as a self-reported history of infertility for at least 2 years. Age and cause of infertility were also recorded.</div></div><div><h3>Results</h3><div>Overall, 2825 participants (17.8 %) reported being infertile. The proportions of women who were underweight (BMI &lt;18.5 kg/m²), overweight (BMI ≥25 and &lt; 30 kg/m²), and obese (BMI ≥ 30 kg/m²) at age 18 were 12.8 %, 4.5 %, and 0.4 %, respectively. Multiple logistic regression analysis revealed a 1.31-fold and a 1.82-fold increase in the rate of infertility in those women who were underweight or obese during adolescence, respectively, compared with those of normal weight. Further analysis by cause of infertility revealed no significant associations with overweight or obesity at age 18, but being underweight was positively associated with infertility of unknown cause.</div></div><div><h3>Conclusions</h3><div>Being underweight or obese at adolescence is a potential risk factor for subsequent infertility among Japanese women. In particular, being underweight during adolescence may be a contributing factor to unexplained infertility later in life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108172"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eligibility criteria for the use menopausal hormone therapy (MHT) in women with medical conditions (II): Endometriosis, neurological and autoimmune diseases","authors":"","doi":"10.1016/j.maturitas.2025.108208","DOIUrl":"10.1016/j.maturitas.2025.108208","url":null,"abstract":"<div><div>This project developed eligibility criteria for menopausal hormone therapy in patients with medical conditions beyond those published in a previous report. A new consortium of scientific societies coordinated by the Spanish Menopause Society met to develop recommendations for the use of menopausal hormone therapy in patients with some medical conditions based on the best available evidence.</div><div>The project was developed in two phases. As a first step, we conducted six systematic reviews and three meta-analyses on the safety of menopausal hormone therapy, addressing six clinical questions related to rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, multiple sclerosis, Parkinson's disease, and endometriosis.</div><div>In the second step, the six systematic reviews and three meta-analyses (one on lupus erythematosus and two on Parkinson's disease) helped inform a structured process in which a panel of experts defined the eligibility criteria according to a specific framework, which facilitated the discussion and development process. The eligibility criteria were defined in accordance with the World Health Organization's international nomenclature for the categories of use of menopausal hormone therapy:<ul><li><span>•</span><span><div>Category 1: No restriction on the use</div></span></li><li><span>•</span><span><div>Category 2: The benefits outweigh the risks.</div></span></li><li><span>•</span><span><div>Category 3: Risks generally outweigh benefits.</div></span></li><li><span>•</span><span><div>Category 4: menopausal hormone therapy should not be used.</div></span></li></ul></div><div>The quality of evidence was classified as high (A), moderate (B), low (C), or very low (D).</div><div>For the first time, a set of eligibility criteria, based on clinical evidence and developed according to the most rigorous methodological tools, has been defined. This will provide health professionals with a decision-making tool that can be used to manage menopausal symptoms.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"195 ","pages":"Article 108208"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}