Maturitas最新文献

{"title":"Treating the genitourinary syndrome of menopause","authors":"Areti Avgoulea","doi":"10.1016/j.maturitas.2025.108332","DOIUrl":"10.1016/j.maturitas.2025.108332","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108332"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effectiveness of ospemifene in treatment of moderate to severe vulvo-vaginal atrophy: the PatiEnt satisfactiON (PEONY) study","authors":"Rossella E. Nappi , Maria Cristina Meriggiola , Angelo Cagnacci , Stefano Luisi , Tommaso Simoncini , Massimo Stomati , Paola Villa , the PatiEnt satisfactiON (PEONY) study","doi":"10.1016/j.maturitas.2025.108291","DOIUrl":"10.1016/j.maturitas.2025.108291","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108291"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmenopausal changes in bone and glucose metabolism in healthy women and women with diabetes mellitus","authors":"Esther M. Speksnijder , Sarah E. Siegelaar , Dirk Jan Stenvers , Peter H. Bisschop","doi":"10.1016/j.maturitas.2025.108336","DOIUrl":"10.1016/j.maturitas.2025.108336","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108336"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘There is absolutely no facet of my life that it hasn't affected’ - experiences of symptoms during perimenopause","authors":"Miriam B. Murphy , Aoife Lane , Geraldine Cuskelly , Patricia M. Heavey","doi":"10.1016/j.maturitas.2025.108319","DOIUrl":"10.1016/j.maturitas.2025.108319","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108319"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment patterns for endocrine therapy-related menopausal symptoms: a cohort study from routine clinical practice in Germany","authors":"Thomas Römer , Carina Dinkel-Keuthage , Cecile Janssenswillen , Martin Lavallee , Carsten Möeller , Nils Schoof , David Vizcaya , Maya Francuski , Asieh Golozar , Victoria Banks","doi":"10.1016/j.maturitas.2025.108284","DOIUrl":"10.1016/j.maturitas.2025.108284","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108284"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estetrol (E4) provides complete relief from vasomotor symptoms in one-third of participants in the E4COMFORT I phase 3 clinical trial","authors":"Tommaso Simoncini , Celine Bouchard , Nicholas Panay , Mélanie Taziaux , Jean-Michel Foidart","doi":"10.1016/j.maturitas.2025.108292","DOIUrl":"10.1016/j.maturitas.2025.108292","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108292"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life improvements with estradiol spray: real-world evidence from Sweden and Finland","authors":"Päivi Polo-Kantola , Maria Lindeberg , Angelica Lindén Hirschberg","doi":"10.1016/j.maturitas.2025.108297","DOIUrl":"10.1016/j.maturitas.2025.108297","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108297"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging and hormonal decline in transgender people: risks and therapeutic options","authors":"Fabian Gomez Giglio","doi":"10.1016/j.maturitas.2025.108326","DOIUrl":"10.1016/j.maturitas.2025.108326","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"199 ","pages":"Article 108326"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interacting and joint effects of type of menopause and age at menopause on the likelihood of frailty and the mediating role of age at menopause in older women: A population-based analysis from NHANES 1999–2018","authors":"Huijie Guo ,&nbsp;Yilu Ye ,&nbsp;Zhihua Liu ,&nbsp;Yunfei Gao ,&nbsp;Guoheng Liu ,&nbsp;Jianguo Zhao ,&nbsp;Ying Yang ,&nbsp;Qun He","doi":"10.1016/j.maturitas.2025.108680","DOIUrl":"10.1016/j.maturitas.2025.108680","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the associations between surgical menopause, age at menopause, and frailty in older women. Furthermore, we examine whether age at menopause mediates the potential association between surgical menopause and frailty, and the extent of interaction or joint effects of surgical menopause and age at menopause on frailty.</div></div><div><h3>Methods</h3><div>The analysis included 7462 women aged ≥60 from the National Health and Nutrition Examination Survey 1999–2018. Frailty was measured using a 49-item frailty index and was diagnosed if the score on that index exceeded 0.21. Menopausal data were collected using a standardized reproductive health questionnaire. Survey-weighted logistic regression models were used to assess the association between surgical menopause, menopausal age, and frailty. We also conducted mediation analyses and interaction analyses on both the multiplicative and additive scales.</div></div><div><h3>Results</h3><div>Of the 7462 women, 2687 (32.4 %) had frailty. Women with a history of surgical menopause had an odds ratio (OR) of 1.44 (95 % CI: 1.25–1.66) for frailty compared to those with natural menopause. Age at menopause mediated 26.4 % of the total association between surgical menopause and frailty. No significant multiplicative or additive interactions were observed in the effects of type of menopause and age at menopause on frailty (Additive: Relative excess risk due to interaction = −0.01, 95 % CI: −0.32–0.31; Multiplicative, OR = 0.94, 95 % CI: 0.75–1.19). Joint ORs for individuals with both surgical and early menopause, compared with those with natural menopause and without early menopause, were 1.59 (95 % CI: 1.40–1.81) for frailty.</div></div><div><h3>Conclusions</h3><div>In postmenopausal women, surgical menopause was significantly associated with a higher likelihood of frailty than natural menopause. Age at menopause mediated more than 26 % of this association.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108680"},"PeriodicalIF":3.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual function after menopause: the role of vaginal estrogens","authors":"Laura Cucinella ,&nbsp;Chiara Cassani ,&nbsp;Ellis Martini ,&nbsp;Giorgia E. Parrotta ,&nbsp;Greta Monne ,&nbsp;Giulia M. Colombo ,&nbsp;Vittoria Morteo ,&nbsp;Rossella E. Nappi","doi":"10.1016/j.maturitas.2025.108681","DOIUrl":"10.1016/j.maturitas.2025.108681","url":null,"abstract":"<div><div>Sexual health and well-being are challenged by the biopsychosocial changes associated with menopause. Local estrogen therapy (LET) represents the mainstay of managing genitourinary syndrome of menopause (GSM). However, most studies have investigated the role of LET on signs and symptoms of vulvovaginal atrophy (VVA) without fully capturing the sexual cluster of symptoms that makes women vulnerable to sexual dysfunction. The present review summarizes studies that have reported the impact of LET on sexual function and its domains (desire, arousal, lubrication, orgasm, pain, and satisfaction). Different formulations (tablet, soft gel inserts, vaginal ring, cream and gel) of estradiol and conjugated equine estrogens at low or ultra-low doses have been investigated. Most evidence supports a positive effect of LET on dyspareunia, while there is less information on the overall sexual experience in healthy postmenopausal women and in those with breast cancer. Importantly, LET has been considered as a class of drugs, with few studies addressing effects of different products on specific symptoms of the GSM constellation to provide evidence for a tailored treatment choice. It appears that GSM management at menopause is a priority to maintain sexual longevity. LET is part of the multifaceted approach to address women's needs and expectations. An evidence-based standard of care is warranted for the use of LET in the management of sexual dysfunction associated with menopause.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"200 ","pages":"Article 108681"},"PeriodicalIF":3.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}