Maturitas最新文献

{"title":"Body image and eating issues in midlife: A narrative review with clinical question recommendations","authors":"Lesley Williams ,&nbsp;Jyoti Gurung ,&nbsp;Patress Persons ,&nbsp;Lisa Kilpela","doi":"10.1016/j.maturitas.2024.108068","DOIUrl":"10.1016/j.maturitas.2024.108068","url":null,"abstract":"<div><p>Midlife is a period of transition that is influenced by multiple biopsychosocial and cultural factors. Eating and body image issues are common at this life stage. The purposes of this narrative review are to explore: 1) the aspects of midlife that make individuals vulnerable to eating issues and body image concerns and 2) how these factors may be influenced by weight, cultural background, and socioeconomic status. Within this review, we aim to explore nuances of how eating and body image issues present in some historically marginalized groups at midlife. The aim is to provide clinicians who care for midlife individuals with practical tools to initiate conversations regarding body image and eating issues. Ideally this will facilitate early intervention and assessment for individuals who are struggling with new, chronic, or relapse of symptoms of disordered eating.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"188 ","pages":"Article 108068"},"PeriodicalIF":3.9,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of menopause with cardiometabolic disease risk factors in women living with and without HIV in sub-Saharan Africa: Results from the AWI-Gen 1 study","authors":"Raylton P. Chikwati ,&nbsp;Nicole G. Jaff ,&nbsp;Nasrin Goolam Mahyoodeen ,&nbsp;Lisa K. Micklesfield ,&nbsp;Michéle Ramsay ,&nbsp;F. Xavier Gómez-Olivé ,&nbsp;Shukri F. Mohamed ,&nbsp;Solomon S.R. Choma ,&nbsp;Jaya A. George ,&nbsp;Nigel J. Crowther","doi":"10.1016/j.maturitas.2024.108069","DOIUrl":"10.1016/j.maturitas.2024.108069","url":null,"abstract":"<div><h3>Background</h3><p>Menopause and HIV are associated with cardiometabolic disease. In sub-Saharan Africa there is a growing population of midlife women living with HIV and a high prevalence of cardiometabolic disease.</p></div><div><h3>Objectives</h3><p>The aim of this study was to determine whether menopause and HIV were associated with cardiometabolic disease risk factors in a population of midlife sub-Saharan African women.</p></div><div><h3>Study design</h3><p>This was a cross-sectional comparison of cardiometabolic disease risk factors between 944 premenopausal women (733 living without HIV and 211 living with HIV) and 1135 postmenopausal women (932 living without HIV and 203 living with HIV) in sub-Saharan Africa.</p></div><div><h3>Main outcome measures</h3><p>Anthropometric and cardiometabolic variables were compared between pre- and postmenopausal women living without HIV and between pre- and postmenopausal women living with HIV and between women living without HIV and women living with HIV.</p></div><div><h3>Results</h3><p>The prevalence of HIV was 19.9 %. Age at menopause was lower in women living with HIV than in women living without HIV (48.1 ± 5.1 vs 50.9 ± 4.7 years, p &lt; 0.001).</p><p>Women living with HIV and receiving efavirenz-based antiretroviral therapy had a lower body mass index (BMI), hip circumference, blood pressure and carotid intima media thickness but higher triglyceride levels and insulin resistance than women living without HIV. Antiretroviral therapy-naïve women living with HIV had lower HDL-cholesterol than women living without HIV.</p><p>In this study, menopause was associated with higher LDL-C levels, regardless of HIV status.</p></div><div><h3>Conclusion</h3><p>The high prevalence of obesity and related cardiometabolic disease risk factors in these midlife sub-Saharan African women is not related to the menopausal transition. The association of cardiometabolic disease risk factors with HIV and antiretroviral therapy is complex and requires further investigation in longitudinal studies, as does the negative association of age at final menstrual period with HIV.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108069"},"PeriodicalIF":3.9,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001646/pdfft?md5=2e74ccb24b118c3b8c71312324d57b52&pid=1-s2.0-S0378512224001646-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Running on empty: Exploring stem cell exhaustion in geriatric musculoskeletal disease","authors":"Amy Lawton ,&nbsp;Nicholas Tripodi ,&nbsp;Jack Feehan","doi":"10.1016/j.maturitas.2024.108066","DOIUrl":"10.1016/j.maturitas.2024.108066","url":null,"abstract":"<div><p>Ageing populations globally are associated with increased musculoskeletal disease, including osteoporosis and sarcopenia. These conditions place a significant burden of disease on the individual, society and the economy. To address this, we need to understand the underpinning biological changes, including stem cell exhaustion, which plays a key role in the ageing of the musculoskeletal system. This review of the recent evidence provides an overview of the associated biological processes. The review utilised the PubMed/Medline, Science Direct, and Google Scholar databases. Mechanisms of ageing identified involve a reaction to the chronic inflammation and oxidative stress associated with ageing, resulting in progenitor cell senescence and adipogenic differentiation, leading to decreased mass and quality of both bone and muscle tissue. Although the mechanisms underpinning stem cell exhaustion are unclear, it remains a promising avenue through which to identify new strategies for prevention, detection and management.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"188 ","pages":"Article 108066"},"PeriodicalIF":3.9,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001610/pdfft?md5=a337c527edb36dd5bb34383f19868f3f&pid=1-s2.0-S0378512224001610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sex hormone binding globulin levels in the association of surgical and natural premature menopause with incident type 2 diabetes","authors":"Shuang Wu ,&nbsp;Qiong Zhong ,&nbsp;Qiying Song ,&nbsp;Mengying Wang","doi":"10.1016/j.maturitas.2024.108063","DOIUrl":"10.1016/j.maturitas.2024.108063","url":null,"abstract":"<div><h3>Objective</h3><p>To examine associations of surgical and natural menopause before the age of 40 years with the risk of type 2 diabetes (T2D) in women.</p></div><div><h3>Methods</h3><p>A total of 273,331 women from the United Kingdom were recruited between 2006 and 2010 in the UK Biobank (UKB) study, and 146,343 women aged 40 to 69 years who were postmenopausal at baseline were included in the analysis. Surgical menopause and natural premature menopause were defined as bilateral oophorectomy before the age of 40 and menopause before the age of 40 without oophorectomy, respectively. Multivariable Cox regression models were used to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between premature menopause and the incidence of T2D.</p></div><div><h3>Results</h3><p>During a median follow-up of 10.4 years, 47 women with surgical premature menopause, 244 women with natural premature menopause, and 4724 women without premature menopause developed T2D. Compared with women without premature menopause, both surgical premature menopause (adjusted HR = 1.46, 95 % CI: 1.09–1.95; <em>P</em> = 0.01) and natural premature menopause (adjusted HR = 1.20, 95 % CI: 1.06–1.37; <em>P</em> &lt; 0.01) were associated with higher risks of incident T2D in the multivariable-adjusted models. Additionally, we observed a significant interaction between levels of sex hormone binding globulin (SHBG) (<em>P</em>_interaction &lt; 0.01) and the effects of premature menopause on incident T2D. The association between premature menopause and T2D risk appeared to be stronger in women with higher SHBG levels. Furthermore, a joint association was detected between premature menopause and the genetic risk score (GRS) of T2D, with a higher score indicating a higher risk of developingT2D. The highest risk of T2D was observed with higher T2D GRS and surgical premature menopause (adjusted HR = 2.61, 95 % CI: 1.65–4.12; <em>P</em> &lt; 0.01).</p></div><div><h3>Conclusions</h3><p>Surgical menopause and natural menopause before the age of 40 years were associated with an increased risk of T2D among postmenopausal women. The findings also suggest potential interactions of premature menopause with SHBG levels, with the association appearing to be stronger in higher SHBG levels, as well as a joint association between menopause status and genetic risk factors on T2D incidence.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108063"},"PeriodicalIF":3.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and psychometric properties of the Balance in Daily Life (BDL) scale in a population of frail older people","authors":"Claire De Labachelerie ,&nbsp;Emilie Viollet ,&nbsp;Sandrine Alonso ,&nbsp;Célia Dauvergne ,&nbsp;Mylène Blot ,&nbsp;Fabrice Nouvel ,&nbsp;Willy Fagart ,&nbsp;Thierry Chevallier ,&nbsp;Anthony Gelis ,&nbsp;Arnaud Dupeyron","doi":"10.1016/j.maturitas.2024.108064","DOIUrl":"10.1016/j.maturitas.2024.108064","url":null,"abstract":"<div><h3>Background</h3><p>Balance disorders in older people cause falls, which can have serious functional and economic consequences. No existing scale relates fall risk to daily life situations. This study describes the development, psychometric properties and construct validity of the Balance in Daily Life (BDL) scale, comprising seven routine tasks including answering a phone, carrying a heavy bag, and sitting down and getting up from a chair.</p></div><div><h3>Methods</h3><p>Frail patients aged 65 years or more were prospectively recruited from the geriatric rehabilitation department of a French university hospital. Inclusion criteria included autonomous walking over 20 m and modified Short Emergency Geriatric Assessment score 8–11. Patients with motor skills disorders and comprehension or major memory difficulties were excluded. Patients were assessed on Day 3 and Day 30 with the Balance in Daily Life scale, Timed Up and Go, one-leg stance time, sternal nudge and walking-while-talking tests. The scale was assessed for acceptability, quality, unidimensionality, internal consistency, reliability, temporal stability, responsiveness and construct validity.</p></div><div><h3>Results</h3><p>140 patients (83 ± 6 years) were recruited, of whom 139 were assessed at Day 0 and 133 at Day 30. Acceptability was satisfactory (134/139 patients completed the test), quality assessment showed a slight floor effect (6 % of patients with minimal score) and evaluation of item redundancy found no strong correlation (Spearman &lt;0.7). Unidimensionality was verified (Loevinger H coefficient &gt; 0.5 for all items except item 6 = 0.4728). Internal consistency was good (Cronbach alpha = 0.86). Reliability and temporal stability were excellent (ICC = 0.97 and ICC = 0.92). Responsiveness was verified by significant score change <em>p</em> &lt; 0.0001 between Day 0 and Day 30 (decreased by 1 [0; 2] point), in line with other score changes. Construct validity revealed that the Balance in Daily Life scale was convergent with results of the timed up-and-go and one-leg stance time (<em>p</em> &lt; 0.0001 for both) and tended to be higher for participants who had not fallen in the previous 6 months (<em>p</em> = 0.0528). The new questionnaire was divergent to sternal nudge tests (<em>p</em> = 0.0002) and not related to the walking-while-talking test (<em>p</em> = 0.5969).</p></div><div><h3>Conclusion</h3><p>The Balance in Daily Life scale has good psychometric properties for this population. Its simplicity and innovative nature mean that it can be applied in institutions while being easily modifiable to domestic settings.</p><p>Study registration on <span><span>clinicaltrials.gov</span><svg><path></path></svg></span>: NCT0334382.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108064"},"PeriodicalIF":3.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001592/pdfft?md5=bfa03f7a81d96989b391d1f1659544be&pid=1-s2.0-S0378512224001592-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based strategies to prevent cognitive decline in older people","authors":"Leon Flicker","doi":"10.1016/j.maturitas.2024.108062","DOIUrl":"10.1016/j.maturitas.2024.108062","url":null,"abstract":"<div><p>A helpful method to understand cognitive decline in older people is to consider this entity as increasing cognitive frailty caused by a number of interacting pathological processes. Over the last 20 years, multiple lifestyle, environmental and constitutional factors have been linked to the development of cognitive decline. For two interventions based on these factors, increasing physical activity and the control of hypertension, there is class 1 evidence for benefit. Other interventions based on these factors do not have the support of high-level evidence for the alteration of cognitive decline, but their other benefits would argue for their implementation. These interventions include increasing education, smoking cessation, avoiding head injuries, decreasing exposure to air pollution and increased social connections. As cognitive decline is experienced almost universally with ageing, and serious cognitive decline is experienced by substantial numbers of low-risk individuals, whole-of-population intervention strategies are the most effective and efficient. For other interventions to help prevent cognitive decline there is not sufficient evidence for their implementation to be recommended. These include alteration of alcohol ingestion, correction of hearing loss, treatment of depression, dietary interventions, menopausal hormone treatment and monoclonal antibodies directed against amyloid-β.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108062"},"PeriodicalIF":3.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001579/pdfft?md5=447dcc0f05d987d95ceaf21ad01e8b86&pid=1-s2.0-S0378512224001579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and behavioral weight management strategies during the menopausal transition: Insights from the Menopause and Weight Loss (ME-WEL) project","authors":"Mafalda Leitão ,&nbsp;Faustino R. Pérez-López ,&nbsp;João Marôco ,&nbsp;Filipa Pimenta","doi":"10.1016/j.maturitas.2024.108060","DOIUrl":"10.1016/j.maturitas.2024.108060","url":null,"abstract":"<div><h3>Objective</h3><p>Most women experience weight gain during the menopausal transition, often attributed to behavioral factors. Nevertheless, some women successfully maintain a healthy weight during this phase. This study aims to identify the successful cognitive and behavioral weight management strategies employed by postmenopausal women who effectively maintained a healthy weight during the menopausal transition (from premenopause to postmenopause).</p></div><div><h3>Method</h3><p>Semi-structured interviews were conducted with 31 Portuguese postmenopausal women, aged 45–65 years (<em>mean and standard deviation</em> 54.06 <em>±</em> 5.51) who successfully maintained a healthy weight (body mass index: 18.5 kg/m²–24.9 kg/m²) during the menopausal transition. The interviews were conducted via telephone <em>(n = 29)</em> and Zoom <em>(n = 2),</em> based on the participant's preference, and ranged from 11 to 52 min <em>(22.06</em> ± 9.95). Using <em>MAXQDA</em> software, deductive-dominant content analysis of the interviews was performed. The <em>Interface of R for the Multidimensional Analyses of Texts and Questionnaire</em> software was used for lexical analysis.</p></div><div><h3>Results</h3><p>The qualitative analysis of <em>cognitive and behavioral strategies for successful weight management</em> yielded 17 categories and 37 sub-categories. Effective cognitive and behavioral strategies (e.g., planning content, stimulus control, support: help from others) were identified, mostly aligning with the Oxford Food and Activity Behaviors Taxonomy. Five new categories emerged: dietary choices, intuitive eating, food literacy, psychological self-care, and effortful inhibition.</p></div><div><h3>Conclusion</h3><p>Knowing effective cognitive and behavioral weight management strategies for menopausal women is relevant, especially considering their status as a high-risk group. This knowledge provides a valuable guide for designing weight management interventions, emphasizing the essential role of behavioral change.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108060"},"PeriodicalIF":3.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001555/pdfft?md5=4ed29ce49cf6d5156b4ac71051ba9008&pid=1-s2.0-S0378512224001555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging frailty and burns: Defining acute burn injury as a cause of long-term frailty","authors":"Adriana C. Panayi ,&nbsp;David N. Herndon ,&nbsp;Ludwik Branski ,&nbsp;Folke Sjöberg ,&nbsp;Gabriel Hundeshagen","doi":"10.1016/j.maturitas.2024.108061","DOIUrl":"10.1016/j.maturitas.2024.108061","url":null,"abstract":"<div><p>Although our understanding of frailty has evolved and multiple indices have been developed, the impact of burn injuries on long-term health has been overlooked. With over 11 million annual cases globally, burns affect all demographics, although socioeconomic disparities are evident. With survival rates improved, morbidity among survivors is becoming more evident, and shows similarity to predictors of frailty. Some of the chronic effects of burns, including mental health issues and increased risks of disease, mirror frailty markers. Studies show burn survivors have lower life expectancy, independent of burn severity. Integrating burn history into frailty assessments and establishing specialized long-term care can mitigate this frailty risk. Improved interdisciplinary follow-up and research are vital for enhancing burn survivors' quality of life and longevity.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108061"},"PeriodicalIF":3.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between frailty, genetic predisposition, and chronic kidney disease risk in middle-aged and older adults: A prospective cohort study","authors":"Honghao Yang ,&nbsp;Zhenhua Li ,&nbsp;Yixiao Zhang ,&nbsp;Qing Chang ,&nbsp;Jinguo Jiang ,&nbsp;Yashu Liu ,&nbsp;Chao Ji ,&nbsp;Liangkai Chen ,&nbsp;Yang Xia ,&nbsp;Yuhong Zhao","doi":"10.1016/j.maturitas.2024.108059","DOIUrl":"10.1016/j.maturitas.2024.108059","url":null,"abstract":"<div><h3>Objectives</h3><p>Cross-sectional evidence has shown that frailty is highly prevalent in patients with chronic kidney disease (CKD). However, there is limited evidence of the longitudinal associations between frailty, genetic predisposition to CKD, and the risk of CKD in the general population. Therefore, this study aimed to examine such associations among participants in the UK Biobank.</p></div><div><h3>Study design</h3><p>This is a prospective cohort study included 370,965 middle-aged and older adults from the UK Biobank. Physical frailty was assessed using a modified version of the Fried phenotype classification. A weighted genetic risk score was built using 263 variants associated with estimated glomerular filtration rate.</p></div><div><h3>Main outcome measures</h3><p>Incident CKD was identified from hospital inpatient records.</p></div><div><h3>Results</h3><p>Over a median follow-up of 12.3 years, we documented a total of 11,121 incident CKD cases. Time-dependent Cox proportional hazards regression models indicated that individuals with frailty (hazard ratio [HR]: 1.94, 95 % confidence interval [CI]: 1.81–2.08) and pre-frailty (HR: 1.27, 95 % CI: 1.22–1.33) had an increased risk of developing CKD, compared with non-frail individuals. No significant interaction between frailty and genetic risk score was observed (<em>P</em> for interaction = 0.41). The highest risk was observed among the individuals with high genetic risk and frailty (HR: 2.31, 95 % CI: 2.00–2.68).</p></div><div><h3>Conclusion</h3><p>Our results demonstrated that frailty and pre-frailty were associated with increased risk of incident CKD in middle-age and older adults, regardless of genetic risk of CKD. Our study underscores the importance of frailty screening and intervention as a potential strategy to prevent CKD. Future clinical trials are needed to validate our findings.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108059"},"PeriodicalIF":3.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the health needs of women with female genital mutilation going through menopause?","authors":"Aini Kamal ,&nbsp;Sarian Kamara ,&nbsp;Rajvinder Khasriya PhD MRCOG ,&nbsp;Sohier Elneil PhD FRCOG ,&nbsp;Louise Newson MCRP FRCGP ,&nbsp;Daniel Reisel DPhil MRCOG","doi":"10.1016/j.maturitas.2024.108058","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108058","url":null,"abstract":"<div><p>Female genital mutilation is widely recognised as a practice that causes grave, permanent damage to the genital anatomy and function. The literature has documented its impact on physical, sexual, emotional, and mental wellbeing, and this has informed the development of guidelines and recommendations for managing women with female genital mutilation. There has, though, been little, if any, focus on how women with female genital mutilation experience menopause. A literature search did not return any published research on the topic and there are currently no clinical guidelines for managing the menopause in women who have undergone female genital mutilation. This review calls attention to this gap by exploring the clinical implications that the loss of natural hormones has on the vulvovaginal tissues, as well as on urogenital and sexual function. Psychological aspects of the experience of women with female genital mutilation going through menopause are also explored, as well as common barriers they face in accessing adequate healthcare. Finally, we offer a set of recommendations for clinical practice, including the need to improve current care pathways, and potential directions for future research.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"187 ","pages":"Article 108058"},"PeriodicalIF":3.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001531/pdfft?md5=5f24887e251f7a382a083bb7f3f08292&pid=1-s2.0-S0378512224001531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}