Maturitas最新文献

{"title":"The future of healthy ageing: Wearables in public health, disease prevention and healthcare","authors":"Marilyne Menassa ,&nbsp;Ilona Wilmont ,&nbsp;Sara Beigrezaei ,&nbsp;Arno Knobbe ,&nbsp;Vicente Artola Arita ,&nbsp;Jose F. Valderrama V ,&nbsp;Lara Bridge ,&nbsp;W.M. Monique Verschuren ,&nbsp;Kirsten L. Rennie ,&nbsp;Oscar H. Franco ,&nbsp;Frans van der Ouderaa","doi":"10.1016/j.maturitas.2025.108254","DOIUrl":"10.1016/j.maturitas.2025.108254","url":null,"abstract":"<div><div>Wearables have evolved into accessible tools for sports, research, and interventions. Their use has expanded to real-time monitoring of behavioural parameters related to ageing and health. This paper provides an overview of the literature on wearables in disease prevention and healthcare over the life course (not only in the older population), based on insights from the Future of Diagnostics Workshop (Leiden, January 2024).</div><div>Wearable-generated parameters include blood glucose, heart rate, step count, energy expenditure, and oxygen saturation. Integrating wearables in healthcare is protracted and far from mainstream implementation, but promises better diagnosis, biomonitoring, and assessment of medical interventions.</div><div>The main lifestyle factors monitored directly with wearables or through smartphone applications for disease prevention include physical activity, energy expenditure, gait, sleep, and sedentary behaviour. Insights on dietary consumption and nutrition have resulted from continuous glucose monitors. These factors are important for healthy ageing due to their effect on underlying disease pathways.</div><div>Inclusivity and engagement, data quality and ease of interpretation, privacy and ethics, user autonomy in decision making, and efficacy present challenges to but also opportunities for their use, especially by older people. These need to be addressed before wearables can be integrated into mainstream medical and public health strategies. Furthermore, six key considerations need to be tackled: 1) engagement, health literacy, and compliance with personalised feedback, 2) technical and standardisation requirements for scalability, 3) accountability, data safety/security, and ethical concerns, 4) technological considerations, access, and capacity building, 5) clinical relevance and risk of overdiagnosis/overmedicalisation, and 6) the clinician's perspective in implementation.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108254"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in body size associated with all-cause mortality in an older Chinese population","authors":"Dechen Liu,&nbsp;Jinjin Wang,&nbsp;Yuqi Niu,&nbsp;Guoli Yan","doi":"10.1016/j.maturitas.2025.108252","DOIUrl":"10.1016/j.maturitas.2025.108252","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence of an association between a change in body size and the risk of all-cause mortality is limited among older populations. We explored the association of a change in body size over three years with the risk of all-cause mortality in an older Chinese population.</div></div><div><h3>Methods</h3><div>A total of 5134 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were recruited. Cox proportional-hazards models were used to assess the association of changes in body mass index (BMI) and body fat percentage (BF%) with risk of all-cause mortality, using hazard ratios (HRs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Of the 5134 participants (median age, 81 years; 2716 women [52.90%]), 1494 deaths were observed over a median of 4.08 years of follow-up. Compared with participants with stable body size (change within 5%), those with more than a 10% decrease in BMI or BF% had 36% and 46% higher risks, respectively, of all-cause mortality (HR = 1.36, 95% CI: 1.17–1.59; and HR = 1.46, 95% CI: 1.25–1.72); also, those with more than a 10% increase in BMI or BF% had 22% and 17% higher risks of all-cause mortality (HR = 1.22, 95% CI: 1.05–1.41; and HR = 1.17, 95% CI: 1.02–1.35).</div></div><div><h3>Conclusions</h3><div>This prospective cohort study of older adults suggests that a dramatic change in body size was positively associated with a higher risk of all-cause mortality. More attention should be paid to the effects of a dramatic change in body size, particularly a dramatic decrease in body size, among the Chinese population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108252"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and performance of the new Guide for the Assessment of Menopausal Symptoms (GAMS) scale, based on the Greene Climacteric Scale: A population survey of French women","authors":"Alexandre Vallée ,&nbsp;Thomas Bozzo ,&nbsp;Maxence Arutkin ,&nbsp;Jean-Marc Ayoubi ,&nbsp;Pierre-François Ceccaldi","doi":"10.1016/j.maturitas.2025.108249","DOIUrl":"10.1016/j.maturitas.2025.108249","url":null,"abstract":"<div><h3>Objective</h3><div>The validity of the Greene Climacteric Scale (GCS) is supported by evidence demonstrating a strong correlation with other measures of menopausal symptoms and quality of life. However, this score, developed 60 years ago, may not be fully applicable the current menopausal population. The purpose of this study was to evaluate the validity of the GCS in a French population and to determine whether an alternative construction of the scale could improve its performance. This led to the development of a new tool: the Guide for the Assessment of Menopausal Symptoms (GAMS) scale.</div></div><div><h3>Methods</h3><div>The 21 questions of the GCS were distributed to French women via social media. The performance of the GCS score in identifying menopausal status was ascertained. Subsequently, the GAMS scale was developed using a training dataset and was validated on a separate dataset.</div></div><div><h3>Results</h3><div>The training dataset included data from 14,518 participants, of whom 3722 (26.64 %) were classified as menopausal. The validation dataset consisted of 3629 participants, of whom 852 (23.48 %) were menopausal. The GCS demonstrated an AUC of 0.53, with a median score of 20 [IQR: 14–27] for menopausal cases and a maximum probability of correct classification of 38 %. In comparison, the GAMS scale achieved an AUC of 0.63, with a median score of 4 [IQR: 2–7] and a maximum probability of correct classification of 70 %.</div></div><div><h3>Conclusion</h3><div>The performance of the GCS in identifying menopausal status is low. Applying weighting coefficients in the GAMS scale improves its performance. Further research is essential to develop tailored and specific menopausal scales that better address women's symptoms and improve their care.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108249"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heritability of bone mineral density among Japanese women: A twin study","authors":"Soichiro Saeki ,&nbsp;Rie Tomizawa ,&nbsp;Kaori Minamitani ,&nbsp;Ken Nakata ,&nbsp;Osaka Twin Research Group ,&nbsp;Chika Honda","doi":"10.1016/j.maturitas.2025.108251","DOIUrl":"10.1016/j.maturitas.2025.108251","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density.</div></div><div><h3>Methods</h3><div>The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density.</div></div><div><h3>Results</h3><div>The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72).</div></div><div><h3>Conclusions</h3><div>Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108251"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating skeletal wellness after breast cancer","authors":"Eleni Armeni","doi":"10.1016/j.maturitas.2025.108250","DOIUrl":"10.1016/j.maturitas.2025.108250","url":null,"abstract":"<div><div>Breast cancer is the leading cause of death in the female population. Hormone receptor-positive cancers are usually treated with surgery in combination with endocrine therapy. The latter is known to lower estrogen levels, contributing, therefore, to loss of bone density (BMD) and higher risk of fracture. Bone-modifying agents (BMAs) can regulate the bone-related adverse effects of cancer treatment. In premenopausal women, intravenous zoledronate effectively prevents bone loss. However, the evidence regarding its ability to reduce disease recurrence remains inconclusive. In postmenopausal women, denosumab demonstrates the most substantial evidence for fracture prevention, supported by one well-powered randomized controlled trial, but has not been shown to confer anticancer benefits. While bisphosphonates effectively prevent and reduce clinical vertebra fractures, their impact on overall fracture risk is unclear. In clinical practice, management of bone health in this group of patients starts with stratification for the risk of fracture. This can be done using the FRAX algorithm; measurements of bone mineral density can help to optimize stratification for individuals at higher fracture risk. Caution is advised when interpreting the results, as the FRAX algorithm has been considered to underestimate the true fracture risk in this population, given that the algorithm has not been adjusted for the effect of anti-cancer agents. Nowadays, clodronate, ibandronate, and zoledronic acid are recommended for bone protection in this group of patients, while denosumab is not. Further research is required to highlight the optimal BMA according to patient characteristics.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108250"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of ballistic vs conventional resistance training in healthy postmenopausal women: A three-arm parallel randomised controlled trial","authors":"Elisa A. Marques ,&nbsp;Ogulcan Caliskan ,&nbsp;Katherine Brooke-Wavell ,&nbsp;Jonathan Folland","doi":"10.1016/j.maturitas.2025.108246","DOIUrl":"10.1016/j.maturitas.2025.108246","url":null,"abstract":"<div><h3>Objectives</h3><div>Power training has gained attention as a method for enhancing functional performance and mitigating fall risk in older adults, yet its long-term feasibility and safety, particularly in ballistic resistance training, remain underexplored in postmenopausal women. We evaluated the feasibility of 8-month ballistic resistance training compared with conventional resistance training in postmenopausal women.</div></div><div><h3>Study design</h3><div>The Resistance Exercise Programme on Risk of Osteoporosis and Osteoarthritis in Females (REPROOF) study was a three-arm parallel group randomised controlled trial at a university lab in the UK. Healthy postmenopausal women (<em>n</em> = 109) were randomised to 30 weeks (2 sessions/week) of lower-body ballistic resistance training, conventional resistance training, or a non-exercising control group.</div></div><div><h3>Main outcome measures</h3><div>The primary outcomes, collected by questionnaire, were process feasibility, acceptability, perceived exercise efficacy, and adverse events.</div></div><div><h3>Results</h3><div>Eighty-two participants completed the trial (75.2 % retention). Both ballistic resistance training and conventional resistance training were well accepted, with most participants rating the intervention positively. No differences in the perceived improvements in physical function and psychological well-being were found between the resistance training groups. Similarly, there was no significant difference in the rate of muscle-related adverse events between the resistance training groups (ballistic, 2.7 per 100 person-weeks; conventional, 2.3 cases per 100 person-weeks), but the rate was significantly lower in the control group (0.9 cases per 100 person-weeks). No serious adverse events occurred during or within 24 h of exercise sessions.</div></div><div><h3>Conclusions</h3><div>The absence of serious adverse events and the observed positive outcomes confirm the safety, satisfaction, and perceived effectiveness of ballistic resistance training, suggesting its potential for broader application in healthy postmenopausal women.</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> registry ID <span><span>NCT05889598</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108246"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity accumulated across adulthood and vasomotor symptoms in pre, peri, and postmenopausal women aged 40–48","authors":"Jovenal Gama-Pinto,&nbsp;Gregore Iven Mielke","doi":"10.1016/j.maturitas.2025.108245","DOIUrl":"10.1016/j.maturitas.2025.108245","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the associations between physical activity accumulated through adulthood and vasomotor symptoms (hot flushes and night sweats) of menopause in women aged 40–48.</div></div><div><h3>Methods</h3><div>Data from 6569 women in the 1973–78 cohort of the Australian Longitudinal Study on Women's Health (ALSHW) were analysed in 2024. Physical activity data were collected every three years from age 22–28 to 43–48. Participants were classified into low, moderate, and high levels of cumulative physical activity based on their reported activity across the surveys. The main outcome was the occurrence of vasomotor symptoms, specifically hot flushes and night sweats, reported by participants at age 40–48.</div></div><div><h3>Results</h3><div>At age 40–48, 21.4 % reported hot flushes (26.6 % low, 20.7 % moderate, 20 % high activity), and 25.5 % reported night sweats (27.7 % low, 24.9 % moderate, 25.0 % high activity). Women with moderate levels of cumulative physical activity from their early 30s to early 40s had 20 % lower odds of experiencing hot flushes than those with low activity levels (OR: 0.80, 95 % CI: 0.67–0.95). This association remained statistically significant after adjusting for sociodemographic factors (OR: 0.83, 95 % CI: 0.69–0.99) but was no longer significant after further adjustment for health-related factors, including alcohol consumption, body mass index, menopausal status, self-rated health, anxiety, and depression. No significant associations were found between cumulative physical activity and vasomotor symptoms for other life stages.</div></div><div><h3>Conclusions</h3><div>Although overall cumulative physical activity levels were not associated with vasomotor symptoms, moderate physical activity levels accumulated from the early 30s to early 40s were associated with lower odds of experiencing hot flushes.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108245"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and outcomes of minimally invasive hysterectomy among older women","authors":"Raanan Meyer ,&nbsp;Ogechukwu Ezike ,&nbsp;Katharine Ciesielski ,&nbsp;Nhat Ngo ,&nbsp;Shainlee Taing ,&nbsp;Walter Gotlieb ,&nbsp;Gabriel Levin","doi":"10.1016/j.maturitas.2025.108244","DOIUrl":"10.1016/j.maturitas.2025.108244","url":null,"abstract":"<div><div>Life expectancy of women in the United States has increased by almost a decade in the last 70 years, and this trend is expected to continue, reaching 83.3 years by 2030, leading to increasing healthcare demands for the older population. This study examines trends in the rates of minimally invasive hysterectomy among women aged 75 years or more and risk factors for postoperative complications, using the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2022. The rate of minimally invasive hysterectomy increased by 50 % during this decade, associated with low postoperative complication rates of 5.9 %. Complications and readmissions were associated with chronic obstructive pulmonary disease and prolonged operative times. Compared with younger cohorts, this older cohort of patients had fewer postoperative complications. Preoperative optimization may improve outcomes further.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108244"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The COVID-19 pandemic's effects on cognition and 24-hour movement behaviours: Findings from the CLSA","authors":"Ryan S. Falck ,&nbsp;Megan E. O'Connell ,&nbsp;Vanessa Taler ,&nbsp;Parminder Raina ,&nbsp;Christina Wolfson ,&nbsp;Lauren E. Griffith ,&nbsp;Eric E. Smith ,&nbsp;Teresa Liu-Ambrose ,&nbsp;Canadian Longitudinal Study on Aging (CLSA) Team","doi":"10.1016/j.maturitas.2025.108243","DOIUrl":"10.1016/j.maturitas.2025.108243","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic may have negatively impacted cognition due to pandemic-associated changes in 24-h movement behaviours (i.e., physical activity, sedentary behaviour, and sleep). Whether the pandemic's effects vary by age and sex is unclear.</div></div><div><h3>Methods</h3><div>We examined those participants (aged 45–85 years) of the Canadian Longitudinal Study on Aging (CLSA) with complete neuropsychological measures at baseline (2011–2015), no dementia/memory disorder, and partial or complete assessments at baseline, 3-year (FU1; 2015–2018), and 6-year follow-up (FU2; 2018–2021). Participants were categorized into pre-pandemic (N = 6174) or intra-pandemic (N = 5181) cohorts by FU2 assessment timing (before/after March 11th, 2020) and stratified by baseline age/sex. Cognition was measured with reliable change indices using: the Rey Auditory-Verbal Learning Test, Mental Alternation Test (MAT), and animal fluency. We indexed physical activity and sedentary behaviour using the Physical Activity Scale for the Elderly (PASE), and self-reported restless sleep.</div></div><div><h3>Findings</h3><div>Compared with their pre-pandemic peers, intra-pandemic men aged 65–85 years had lower animal fluency (−0.40 points, 99 % CI: [−0.72, −0.07]), lower PASE (−16.48 points, 99 % CI: [−24.60, −8.36]) and 14 % higher probability of ≥4 h/day sedentary behaviour (99 % CI: [0.03, 0.26]) at FU2. Intra-pandemic women aged 65–85 years had lower MAT (−0.43 points, 99 % CI: [−0.86, −0.01]) and 12 % higher probability of ≥4 h/day sedentary behaviour (99 % CI: [0.01, 0.23]). There were no between-cohort differences for those aged 45–64 years. Pandemic-related changes in 24-h movement behaviours (FU1 to FU2) were not associated with cognitive changes, regardless of age or sex.</div></div><div><h3>Interpretation</h3><div>The pandemic's effects on cognition and 24-h movement behaviours varied by age and sex; these effects are unrelated.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108243"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns derived using reduced rank regression in postmenopausal women and risk of mortality: A population-based study","authors":"Mojgan Amiri ,&nbsp;Hamidreza Raeisi-Dehkordi ,&nbsp;Marinka Steur ,&nbsp;Giorgia Grisotto ,&nbsp;Fernando Rivadeneira ,&nbsp;M. Kamran Ikram ,&nbsp;Maryam Kavousi ,&nbsp;Taulant Muka ,&nbsp;Trudy Voortman","doi":"10.1016/j.maturitas.2025.108234","DOIUrl":"10.1016/j.maturitas.2025.108234","url":null,"abstract":"<div><h3>Objectives</h3><div>The menopause transition increases the risk of chronic conditions in women. Given the crucial role of diet in health, we identified dietary patterns that explain variations in factors related to major health concerns in postmenopausal women. Also, we explored their association with all-cause and cardiovascular mortality.</div></div><div><h3>Study design</h3><div>This study was conducted on 1814 postmenopausal women from the population-based Rotterdam Study.</div></div><div><h3>Main outcome measures</h3><div>Dietary patterns were identified using reduced rank regression. Response variables included bone mineral density, body composition parameters, lipid profile markers, insulin resistance, systolic blood pressure, cognitive function, depression, and sleep quality. The associations with risk of mortality were assessed using Cox proportional hazard models.</div></div><div><h3>Results</h3><div>The first dietary pattern, characterized by higher intake of vegetables, whole grains, legumes, nuts, coffee, tea, alcoholic beverages, and cheese, explained 2.95 % of the variation in responses, accounted for 12.11 % of the variation in general cognitive function captured by G-factor, 5.62 % in systolic blood pressure, and 4.13 % in bone mineral density, and was correlated with less adiposity, lower blood pressure, lipid markers, and insulin resistance. The second dietary pattern, characterized by higher intakes of processed meat, unprocessed red meat, poultry, eggs, and coffee, and lower intakes of sweets and tea, explained 1.54 % of the variation in responses, accounted for 5.45 % of variation in fat mass percentage, 3.47 % in lean mass index, and 3.29 % in bone mineral density, and was correlated with higher adiposity, insulin resistance, and lipid markers. No associations with mortality risk were identified after adjusting for confounders such as demographics, socioeconomic status, lifestyle, disease history, and medication use.</div></div><div><h3>Conclusions</h3><div>We identified dietary patterns explaining a range of variation in health factors related to postmenopausal health. While these dietary patterns explained a large variation in some of the individual factors, their combined explained variation across multiple risk factors simultaneously was limited and no significant association with mortality risk was observed. This study provides a foundation for future research aimed at identifying optimal dietary patterns, integrating diverse health aspects, to improve health in postmenopausal populations.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108234"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}