Maturitas最新文献

{"title":"Being underweight or obese in adolescence may increase the risk of female infertility later in life: The Japan Nurses' Health Study","authors":"Miho Iida ,&nbsp;Yuki Ideno ,&nbsp;Kazue Nagai ,&nbsp;Yukiko Miyazaki ,&nbsp;Ryota Toki ,&nbsp;Yasunori Sato ,&nbsp;Takeshi Iwasa ,&nbsp;Naoko Arata ,&nbsp;Takumi Kurabayashi ,&nbsp;Kunihiko Hayashi","doi":"10.1016/j.maturitas.2024.108172","DOIUrl":"10.1016/j.maturitas.2024.108172","url":null,"abstract":"<div><h3>Objectives</h3><div>Underweight or obesity is associated with infertility in women, but large cohort studies with a life course perspective are rare. We explored the association between body mass index (BMI) at age 18 and subsequent infertility among Japanese women.</div></div><div><h3>Study design</h3><div>In total, 15,907 married women aged 30–44 years who participated in a prospective cohort baseline survey during 2001–2007 were cross-sectionally analyzed. Those with a history of cancer, and those with a partner with infertility or missing data were excluded. All data were obtained from self-reported questionnaires.</div></div><div><h3>Main outcome measures</h3><div>The main outcome measure was infertility, defined as a self-reported history of infertility for at least 2 years. Age and cause of infertility were also recorded.</div></div><div><h3>Results</h3><div>Overall, 2825 participants (17.8 %) reported being infertile. The proportions of women who were underweight (BMI &lt;18.5 kg/m²), overweight (BMI ≥25 and &lt; 30 kg/m²), and obese (BMI ≥ 30 kg/m²) at age 18 were 12.8 %, 4.5 %, and 0.4 %, respectively. Multiple logistic regression analysis revealed a 1.31-fold and a 1.82-fold increase in the rate of infertility in those women who were underweight or obese during adolescence, respectively, compared with those of normal weight. Further analysis by cause of infertility revealed no significant associations with overweight or obesity at age 18, but being underweight was positively associated with infertility of unknown cause.</div></div><div><h3>Conclusions</h3><div>Being underweight or obese at adolescence is a potential risk factor for subsequent infertility among Japanese women. In particular, being underweight during adolescence may be a contributing factor to unexplained infertility later in life.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108172"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bio-psycho-social investigation of menopause transition and job satisfaction","authors":"Carol Atkinson ,&nbsp;Fiona Carmichael ,&nbsp;Jo Duberley","doi":"10.1016/j.maturitas.2024.108187","DOIUrl":"10.1016/j.maturitas.2024.108187","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the implications of menopause transition for job satisfaction within a framework that integrates bio-psycho-social factors and effects.</div></div><div><h3>Study design</h3><div>The study analyses quantitative and qualitative data from a survey of 1684 women in three UK police forces, where growing numbers work during menopause transition within what has been termed a hyper-masculine culture.</div></div><div><h3>Results</h3><div>We evidence that job satisfaction is negatively impacted by experience of menopause symptoms. Attitudes towards age and menopause are also important: job satisfaction is lower for peri- and post-menopausal women with negative attitudes and higher for women with more positive and open attitudes. Some workplace factors such as shift working and the gender balance of the workplace also have a significant impact on the job satisfaction of women transitioning menopause.</div></div><div><h3>Conclusion</h3><div>Our results highlight the need for human resource practices that go beyond the typical focus on symptoms. Support mechanisms need to address attitudes towards menopause and develop more inclusive workplaces in order to maintain women's job satisfaction and retain them in the workplace during menopause transition.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"193 ","pages":"Article 108187"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eligibility criteria for the use menopausal hormone therapy (MHT) in women with medical conditions (II): Endometriosis, neurological and autoimmune diseases","authors":"","doi":"10.1016/j.maturitas.2025.108208","DOIUrl":"10.1016/j.maturitas.2025.108208","url":null,"abstract":"<div><div>This project developed eligibility criteria for menopausal hormone therapy in patients with medical conditions beyond those published in a previous report. A new consortium of scientific societies coordinated by the Spanish Menopause Society met to develop recommendations for the use of menopausal hormone therapy in patients with some medical conditions based on the best available evidence.</div><div>The project was developed in two phases. As a first step, we conducted six systematic reviews and three meta-analyses on the safety of menopausal hormone therapy, addressing six clinical questions related to rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, multiple sclerosis, Parkinson's disease, and endometriosis.</div><div>In the second step, the six systematic reviews and three meta-analyses (one on lupus erythematosus and two on Parkinson's disease) helped inform a structured process in which a panel of experts defined the eligibility criteria according to a specific framework, which facilitated the discussion and development process. The eligibility criteria were defined in accordance with the World Health Organization's international nomenclature for the categories of use of menopausal hormone therapy:<ul><li><span>•</span><span><div>Category 1: No restriction on the use</div></span></li><li><span>•</span><span><div>Category 2: The benefits outweigh the risks.</div></span></li><li><span>•</span><span><div>Category 3: Risks generally outweigh benefits.</div></span></li><li><span>•</span><span><div>Category 4: menopausal hormone therapy should not be used.</div></span></li></ul></div><div>The quality of evidence was classified as high (A), moderate (B), low (C), or very low (D).</div><div>For the first time, a set of eligibility criteria, based on clinical evidence and developed according to the most rigorous methodological tools, has been defined. This will provide health professionals with a decision-making tool that can be used to manage menopausal symptoms.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"195 ","pages":"Article 108208"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus, vaginal microbiome and sexual function: Outcomes in postmenopausal women","authors":"Roberta Scairati ,&nbsp;Renata S. Auriemma ,&nbsp;Guendalina Del Vecchio ,&nbsp;Sara Di Meglio ,&nbsp;Rosa Pirchio ,&nbsp;Chiara Graziadio ,&nbsp;Rosario Pivonello ,&nbsp;Annamaria Colao","doi":"10.1016/j.maturitas.2025.108210","DOIUrl":"10.1016/j.maturitas.2025.108210","url":null,"abstract":"<div><div>Diabetes mellitus is a chronic disease and a public health challenge worldwide, associated with numerous complications, including genitourinary infections and sexual dysfunction in women, particularly in menopause. The vaginal microbiome, which comprises beneficial and pathogenic bacteria, their genomes, and the surrounding environment, plays a crucial role in maintaining genitourinary health. Chronic hyperglycemia disrupts immune functions, exacerbates oxidative stress, and alters the vaginal microbiome, increasing the risk of genitourinary infections. Recent advances in microbial analysis, including 16S rRNA sequencing, have provided insights into the complex composition of the vaginal microbiome and its dysbiosis in diabetes mellitus. Some glucose-lowering drugs, such as sodium-glucose cotransporter 2 inhibitors, may increase the risk of genitourinary infections. Additionally, psychological distress, hormonal imbalances, and diabetes-related genitourinary symptoms contribute to sexual dysfunction in diabetic women. Healthcare for diabetic women requires a multidisciplinary approach, including not only glycemic control but also vaginal and sexual health assessment. A holistic approach is essential to advance personalized strategies, including medications and psychological support.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108210"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis as a risk factor for age-related macular degeneration: A nationwide population-based study","authors":"Jyun-Lin Lee ,&nbsp;Yu-An Hsu ,&nbsp;Yu-Te Huang ,&nbsp;Jamie Jiin-Yi Chen ,&nbsp;Ming-Yen Wu ,&nbsp;Fuu-Jen Tsai ,&nbsp;Hui-Ju Lin ,&nbsp;Yu-Han Huang ,&nbsp;Peng-Tai Tien ,&nbsp;Lei Wan","doi":"10.1016/j.maturitas.2025.108211","DOIUrl":"10.1016/j.maturitas.2025.108211","url":null,"abstract":"<div><h3>Objective</h3><div>Investigate the association between endometriosis and the incidence of age-related macular degeneration.</div></div><div><h3>Material and methods</h3><div>This study used data from Taiwan's National Health Insurance Research Database (2000–2018) to examine the link between endometriosis and age-related macular degeneration. The endometriosis cohort included women diagnosed with the condition, with the index date set as their first diagnosis. A control group of women without endometriosis was matched using propensity score matching based on age, year of the index date, and comorbidities. The primary outcome was the occurrence of age-related macular degeneration during the study period. The incidence of age-related macular degeneration was compared between the two cohorts using a Cox regression model, and the risk of developing age-related macular degeneration was estimated with the Kaplan–Meier method.</div></div><div><h3>Results</h3><div>The study included 53,993 individuals per group, with no significant differences in age or comorbidities. The mean follow-up duration was significantly longer for the endometriosis cohort (10.18 years) than the non-endometriosis cohort (9.96 years). Patients with endometriosis exhibited a significantly higher risk of age-related macular degeneration (adjusted hazard ratio = 1.43, 95 % confidence interval: 1.26–1.63, <em>p</em> &lt; 0.001) after adjusting for age and comorbidities. The Kaplan–Meier curves confirmed an increased cumulative incidence of age-related macular degeneration in the endometriosis cohort. Subgroup analysis revealed a higher risk of age-related macular degeneration in patients with endometriosis across various age groups and in those without comorbidities.</div></div><div><h3>Conclusion</h3><div>This study demonstrated a significant association between endometriosis and the risk of developing age-related macular degeneration in women.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"195 ","pages":"Article 108211"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143333394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The implications of bioelectrical impedance vector analysis in older adults with hip fractures","authors":"Seung-Kyu Lim ,&nbsp;Jae-Young Lim","doi":"10.1016/j.maturitas.2025.108209","DOIUrl":"10.1016/j.maturitas.2025.108209","url":null,"abstract":"<div><h3>Objectives</h3><div>This study used bioelectrical impedance vector analysis to assess body composition in older adults with hip fractures, comparing results with reference populations.</div></div><div><h3>Study design</h3><div>This cross-sectional study included patients aged 65 years or more who had undergone surgery for hip fracture and baseline bioelectrical impedance analysis at 50 kHz. Using raw impedance data, bioelectrical impedance vector analysis was conducted, calculating phase angle and analyzing resistance (R) and reactance (Xc) relative to height (R/H and Xc/H) on RXc graphs.</div></div><div><h3>Main outcome measures</h3><div>Men and women were compared with reference populations using confidence ellipses. Individual vectors were plotted against 50 %, 75 %, and 95 % tolerance ellipses and compared with international references matched for age and body mass index and a young adult group, further differentiated by sarcopenia status.</div></div><div><h3>Results</h3><div>Among 103 patients with hip fracture (24 men, 79 women), confidence ellipses showed significant differences from reference populations (P &lt; 0.001), with reduced Xc and lower phase angle (men: 4.3 ± 1.5°; women: 3.8 ± 1.0°), consistent with higher R/H and lower Xc/H. Most vectors lay outside the 75 % and 95 % tolerance ellipses, primarily in the lower-right and upper-right quadrants, indicating body cell mass loss and water imbalance. Only 8.3 % of men and 12.7 % of women fell within the 75 % tolerance ellipse of community-dwelling older adults. Sarcopenic patients showed greater rightward displacement, indicating more severe muscle wasting and dehydration.</div></div><div><h3>Conclusions</h3><div>Older hip fracture patients showed a distinct pattern on bioelectrical impedance vector analysis indicating frailty and malnutrition. Bioelectrical impedance vector analysis may effectively screen for body composition changes and nutritional status, supporting timely, multidisciplinary interventions.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108209"},"PeriodicalIF":3.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationships between Sex Hormones and Abdominal Muscle Area and Radiodensity in Postmenopausal Women: Insights from the Multi-Ethnic Study of Atherosclerosis","authors":"Amar Osmancevic ,&nbsp;Matthew Allison ,&nbsp;Iva Miljkovic ,&nbsp;Chantal A. Vella ,&nbsp;Pamela Ouyang ,&nbsp;Penelope Trimpou ,&nbsp;Bledar Daka","doi":"10.1016/j.maturitas.2025.108197","DOIUrl":"10.1016/j.maturitas.2025.108197","url":null,"abstract":"<div><div>The relationships between sex hormone levels and muscle composition in postmenopausal women remain underexplored. To address this gap, we conducted a cross-sectional observational study utilizing data from the Multi-Ethnic Study of Atherosclerosis. Our analysis included 682 postmenopausal women aged 45–84 years with complete data, with a mean age of 63.3 years. Using abdominal computed tomography, we assessed abdominal muscle area (cm²) and muscle radiodensity (Hounsfield units) in relation to serum levels of testosterone (total and free), estradiol, and sex hormone binding globulin (SHBG), measured in nmol/L.</div><div>Multivariable linear regression models, adjusting for potential confounders, were employed to investigate these associations. In our fully adjusted models, higher levels of estradiol and free testosterone were found to be positively associated with total area of abdominal muscle (β = 1.41, 95 % CI 0.4, 2.4, p = 0.007 and β = 18.5, 95 % CI 4.0, 33.1, p = 0.004, respectively), but not with muscle radiodensity (p &gt; 0.05). Conversely, elevated levels of SHBG were associated with a smaller total of area abdominal muscle and radiodensity (β = −2.1, 95 % CI -3.2, −0.9, p = 0.001 and β = −0.32, 95 % CI -0.6, −0.0, p = 0.07, respectively).</div><div>Our study highlights significant associations between sex hormone levels and skeletal muscle area in postmenopausal women. Furthermore, the novel findings regarding SHBG and muscle composition suggest a potential previously unrecognized role of SHBG in the accumulation of skeletal muscle adipose tissue. However, further validation in other cohorts is necessary to elucidate the potential role of SHBG in body composition.</div><div>Clinical Trial: <span><span>NCT00005487</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108197"},"PeriodicalIF":3.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of changes in body composition on cardiometabolic diseases by sex and presence of sarcopenia","authors":"Junhee Park ,&nbsp;Hyung Eun Shin ,&nbsp;Miji Kim ,&nbsp;Chang Won Won","doi":"10.1016/j.maturitas.2025.108207","DOIUrl":"10.1016/j.maturitas.2025.108207","url":null,"abstract":"<div><h3>Background</h3><div>Muscle mass loss and fat mass increase are risk factors for cardiometabolic disease. We evaluated the effect of changes in body composition on the incidence of cardiometabolic diseases in older adults with or without sarcopenia, over two-year follow-up.</div></div><div><h3>Materials and methods</h3><div>Changes in body composition and the development of cardiometabolic diseases over 2 years were measured in community-dwelling older adults recruited from the Korean Frailty Aging Cohort Study. Individuals with sarcopenia were 1:1 matched to those without sarcopenia via propensity score matching.</div></div><div><h3>Results</h3><div>Among a total of 1634 eligible subjects, 353 were identified with sarcopenia. In men without sarcopenia, an increase in waist circumference by 1 cm was associated with a 32 % higher risk of the development of hypertension. Conversely, an increase in appendicular lean mass by 1 kg was associated with lower risks of the development of cardiovascular disease (41 % lower) and hyperlipidemia (28 % lower). However, there were no significant associations between changes in body composition and any incident cardiometabolic diseases in men with sarcopenia. Women without sarcopenia who experienced an increase in weight of 1 kg were 21 % less likely to develop hyperlipidemia. In women with sarcopenia, the risk of diabetes mellitus was reduced by 30 % with an incremental increase in weight by 1 kg, while the risk of hyperlipidemia increased almost threefold with an increase in appendicular lean mass by 1 kg.</div></div><div><h3>Conclusions</h3><div>In older adults without sarcopenia, a decrease in obesity-related indices and a gain in muscle gain are beneficial for men, but inverse relationships between weight and cardiometabolic diseases were reported in women. We found no cardiometabolic benefit of increasing lean mass in older adults with sarcopenia regardless of sex.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108207"},"PeriodicalIF":3.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the regenerative potential of vaginal fibroblasts: The role of autologous platelet-rich plasma and hyaluronic acid in vitro","authors":"Sarah Berndt ,&nbsp;Solange Vischer ,&nbsp;Antoine Turzi ,&nbsp;Patrick Dällenbach","doi":"10.1016/j.maturitas.2025.108196","DOIUrl":"10.1016/j.maturitas.2025.108196","url":null,"abstract":"<div><h3>Objective</h3><div>Many postmenopausal women suffering from vulvovaginal atrophy are looking for non-hormonal treatments. Platelet-rich plasma (PRP) therapy has emerged as a novel and promising approach for gynecological applications. PRP is an autologous blood product rich in growth factors used to stimulate tissue regeneration. On the other hand, hyaluronic acid (HA) is used as a treatment for vaginal dryness as it improves tissue hydration thanks to its strong capacity to retain water. This study examines the in vitro effects of PRP alone or combined with HA on vaginal fibroblasts (VFs) isolated from mucosal samples of postmenopausal women undergoing surgery for vaginal prolapse.</div></div><div><h3>Methodology</h3><div>Vaginal and blood samples were collected from postmenopausal women undergoing pelvic organ prolapse surgery. PRP was prepared alone or combined with HA (PRP-HA) from peripheral blood. Vaginal fibroblasts were isolated via enzymatic dissociation and cultured in 2D and 3D (spheroids) systems. Biological activities were assessed by measuring cell growth, proliferation, senescence, metabolic activity, and collagen accumulation, along with immunocytochemistry for (myo-)fibroblast markers.</div></div><div><h3>Results</h3><div>VFs cultured with PRP or PRP-HA showed dose-dependent higher proliferation compared with the control condition, with increased S and G2M cell cycle phases correlating with enhanced proliferation. Expression of vimentin, a protein that plays a key role in maintaining cellular structure and function, was stable, while alpha-SMA decreased, indicating a shift from myofibroblasts to fibroblasts. Collagen production, crucial for wound healing and tissue regeneration, increased under PRP or PRP-HA treatment. PRP and PRP-HA also prevented cell senescence in long-term low-density cultures. These findings were consistent across 2D and 3D culture systems.</div></div><div><h3>Conclusions</h3><div>This study provides in vitro evidence supporting the potential of PRP and PRP-HA as autologous treatments for vaginal rejuvenation.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108196"},"PeriodicalIF":3.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Rose angina in midlife women matter? Further evidence from the Royal College of General Practitioners' Oral Contraception Study","authors":"Katarzyna Galka ,&nbsp;David J. McLernon ,&nbsp;Philip C. Hannaford ,&nbsp;Lisa Iversen","doi":"10.1016/j.maturitas.2024.108189","DOIUrl":"10.1016/j.maturitas.2024.108189","url":null,"abstract":"<div><h3>Background and aims</h3><div>Globally, ischaemic heart disease (IHD) is a leading cause of death among women; however, disparities remain in the diagnosis and treatment of IHD between females and males. There is limited evidence about mortality risks among women with symptoms of IHD who remain undiagnosed. We re-examined the mortality risks in midlife women who completed the Rose Angina Questionnaire, among a subset of the Royal College of General Practitioners' Oral Contraception Study cohort.</div></div><div><h3>Methods</h3><div>8694 women in the cohort completed the Rose Angina Questionnaire, enquiring about symptoms of exertional chest pain, likely angina, and prior myocardial infarction. The women were followed for vital status and cause of death information until 30 June 2022. The relationship between different types of Rose angina and all-cause and cause-specific mortality was examined using Kaplan-Meier survival curves, and unadjusted and adjusted Cox regression.</div></div><div><h3>Results</h3><div>After 27 years, 3263 (37.5 %) women had died. Compared with women who did not report symptoms, women with Rose angina had an increased risk of all-cause and IHD death. Women without a prior IHD diagnosis and grade II Rose angina at survey had the highest all-cause (adjusted hazard ratio [aHR] 2.14, 95 % confidence interval [CI] 1.55 to 2.97) and IHD-specific (aHR 3.18, 95 % CI 1.64 to 6.17) mortality risks.</div></div><div><h3>Conclusions</h3><div>Women reporting Rose chest pain had a higher risk of all-cause and IHD death, even in the absence of a prior IHD history. These findings highlight the importance of identifying symptomatic women in midlife, so their IHD risk can be managed appropriately by their healthcare providers.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"194 ","pages":"Article 108189"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}