Maturitas最新文献

{"title":"Total choline intake, liver fibrosis and the progression of metabolic dysfunction-associated steatotic liver disease: Results from 2017 to 2020 NHANES","authors":"Siraphat Taesuwan ,&nbsp;Matina Kouvari ,&nbsp;Andrew J. McKune ,&nbsp;Demosthenes B. Panagiotakos ,&nbsp;Julaluk Khemacheewakul ,&nbsp;Noppol Leksawasdi ,&nbsp;Pornchai Rachtanapun ,&nbsp;Nenad Naumovski","doi":"10.1016/j.maturitas.2024.108150","DOIUrl":"10.1016/j.maturitas.2024.108150","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the cross-sectional relationships of total choline intake with the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to liver fibrosis.</div></div><div><h3>Study design</h3><div>The study used data on total choline intake, hepatic steatosis, and liver fibrosis from the cross-sectional 2017–2020 National Health and Nutrition Examination Survey, including 24-h dietary recalls and liver ultrasound elastography (FibroScan®).</div></div><div><h3>Main outcome measures</h3><div>Steatosis was defined as a controlled attenuation parameter score ≥ 285<!--> <!-->dB/m. Fibrosis was defined as median liver stiffness ≥8 kPa. Complex survey-adjusted regression models were used in all analyses. Effect modification by sex, race, and cardiometabolic risk factors was investigated.</div></div><div><h3>Result</h3><div>Total choline intake was not associated with MASLD status (<em>n</em> = 5687; odds ratio per 100 mg/d [95 % confidence interval]: 0.96 [0.85,1.09]; <em>P</em> = 0.55). However, among people with MASLD, a higher total choline intake was associated with higher odds of fibrosis (<em>n</em> = 2019; 1.15 [1.01,1.30]; <em>P</em> = 0.03). This association was observed in men (<em>P</em>-interaction = 0.1; 1.23 [1.02,1.48]; <em>P</em> = 0.03), but not in women (1.05 [0.88,1.24]; <em>P</em> = 1.0). Choline intake also tended to be positively associated with fibrosis in people with MASLD who were overweight or had central obesity (<em>P</em>-interaction = 0.02; 1.15 [1.00,1.34]; <em>P</em> = 0.06).</div></div><div><h3>Conclusions</h3><div>Overall, no significant association was observed between total choline intake and the prevalence of MASLD. However, in people with MASLD, a higher choline intake was associated with higher odds of developing liver fibrosis. This association appeared to differ by sex and cardiometabolic risk factors.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108150"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic associations of miRNA variants (miR-10a, miR-30c, miR-181a, miR-499b) with primary ovarian insufficiency in Korean women","authors":"Hui Jeong An ,&nbsp;Sung Hwan Cho ,&nbsp;Chang Soo Ryu ,&nbsp;Eun Ju Ko ,&nbsp;Hyeon Woo Park ,&nbsp;Young Ran Kim ,&nbsp;Eun Hee Ahn ,&nbsp;Ji Eun Shin ,&nbsp;Seong-Soo Joo ,&nbsp;Ji Hyang Kim ,&nbsp;Nam Keun Kim","doi":"10.1016/j.maturitas.2024.108153","DOIUrl":"10.1016/j.maturitas.2024.108153","url":null,"abstract":"<div><h3>Objectives</h3><div>MicroRNAs (miRNAs) are pivotal in post-transcriptionally modulating gene expression in both animals and plants. This study investigates the relationship between microRNA polymorphisms and the occurrence of primary ovarian insufficiency in Korean women. Our hypothesis posits that polymorphisms in microRNAs—specifically miR-10aA &gt; T, miR-30cA &gt; G, miR-181aT &gt; C, and miR-499bA &gt; G—may be linked to primary ovarian insufficiency, influencing the risk of developing the condition.</div></div><div><h3>Methods</h3><div>We conducted a case-control study of 141 Korean women with primary ovarian insufficiency and 281 control individuals with at least one live birth and no history of pregnancy loss.</div></div><div><h3>Results</h3><div>Our findings indicate that various combinations of these four microRNA polymorphic sites are associated with an increased risk of primary ovarian insufficiency. The combination analysis indicated a significant decrease in the frequency of the miR-181a/miR-499b TC/AA allele combination in individuals with primary ovarian insufficiency (<em>P</em> &lt; 0.05). Additionally, one-way analysis of variance of data from patients with primary ovarian insufficiency revealed that, in comparison with miR-181aTT, the miR-181aCC genotype was associated with significantly lower levels of both follicle-stimulating hormone and luteinizing hormone, suggesting potential protective effects.</div></div><div><h3>Conclusions</h3><div>Our data suggest that dysregulation of the miR-10aA &gt; T, miR-30cA &gt; G, miR-181aT &gt; C, and miR-499bA &gt; G polymorphisms in these microRNAs contributes to the regulation of target genes related to primary ovarian insufficiency.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108153"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the partner's obstructive sleep apnea on metabolic syndrome in couples","authors":"Kayoung Lee","doi":"10.1016/j.maturitas.2024.108147","DOIUrl":"10.1016/j.maturitas.2024.108147","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the relationship between the risk of obstructive sleep apnea, as assessed by the STOP-Bang questionnaire, and metabolic syndrome among couples. It also examines how snoring and observed apnea are associated with metabolic syndrome in couples.</div></div><div><h3>Study design</h3><div>Cross-sectional study using data from 2436 couples in the Korea National Health and Nutrition Examination Survey (2019–2021). A high risk of obstructive sleep apnea was defined as a STOP-Bang score of 3 or more (excluding the hypertension item).</div></div><div><h3>Main outcome measures</h3><div>Metabolic syndrome in couples.</div></div><div><h3>Results</h3><div>47.6 % of husbands and 5.7 % of wives had a high risk of obstructive sleep apnea. The prevalence of metabolic syndrome was 45.5 % among husbands and 24.7 % among wives. After adjusting for sociodemographic factors and health behaviors, wives whose husbands were at high risk of obstructive sleep apnea or who reported snoring or observed apnea had 1.4–1.5 times higher odds of metabolic syndrome. Conversely, husbands' metabolic syndrome was not significantly associated with their wives' risk of obstructive sleep apnea and sleep behaviors. The adjusted odds of metabolic syndrome in both partners were 2.8–4.4 times higher when only husbands had a high risk of obstructive sleep apnea or snoring, and 2.3–2.9 times higher when only wives had these sleep issues, compared with couples without such problems.</div></div><div><h3>Conclusions</h3><div>This study reveals a gender disparity in the impact of a spouse's risk of obstructive sleep apnea on metabolic syndrome, emphasizing the need for a couple-focused approach in managing these health issues.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108147"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a home-based exercise program on subsequent falls among community-dwelling older adults with cognitive frailty: A sub-group analysis of a randomized controlled trial","authors":"Ryan S. Falck ,&nbsp;Chun Liang Hsu ,&nbsp;Jennifer C. Davis ,&nbsp;Jordyn Rice ,&nbsp;Elizabeth Dao ,&nbsp;Larry Dian ,&nbsp;Kenneth Madden ,&nbsp;Dawn A. Skelton ,&nbsp;Naaz Parmar ,&nbsp;Wendy L. Cook ,&nbsp;Karim M. Khan ,&nbsp;Teresa Liu-Ambrose","doi":"10.1016/j.maturitas.2024.108151","DOIUrl":"10.1016/j.maturitas.2024.108151","url":null,"abstract":"<div><h3>Objectives</h3><div>Cognitive frailty is characterized by concurrent physical frailty and mild cognitive impairment and is associated with increased risk of falls. Exercise is an evidence-based strategy to prevent falls, but whether exercise reduces falls in people with cognitive frailty is unknown. We examined the effects of home-based exercise on subsequent falls among community-dwelling older adults with cognitive frailty who have previously fallen.</div></div><div><h3>Study design</h3><div>A sub-group analysis of a 12-month, single-blind, randomized controlled trial among 344 adults aged 70 years or more who had fallen within the past 12 months. Participants were randomized to either 12 months of home-based exercise (<em>n</em>=172) or usual care (n=172). In this sub-analysis, we included 192 participants with cognitive frailty (home-based exercise=93; usual care=99) with Short Physical Performance Battery scores ≤9/12 and Montreal Cognitive Assessment scores &lt;26/30.</div></div><div><h3>Main outcome measures</h3><div>Our primary analysis examined the effect of exercise on self-reported falls rate over 12 months. Secondary analyses investigated the intervention's effects on scores on the Short Physical Performance Battery and the Montreal Cognitive Assessment. We also explored whether greater than or equal to mean average monthly adherence (i.e., ≥45.5%) moderated treatment effects.</div></div><div><h3>Results</h3><div>At 12 months, falls rates were 35% lower in the home-based exercise group compared with the usual care group (IRR=0.65; <em>p</em><em>=</em>0.042). Score on the Short Physical Performance Battery significantly improved among home-based exercise participants with greater than or equal to mean adherence vs. those with less than mean adherence (estimated mean difference: 0.94; <em>p</em>=0.022).</div></div><div><h3>Conclusions</h3><div>Exercise is a promising strategy for reducing subsequent falls in people with cognitive frailty. Greater exercise adherence improved physical function in this population.</div><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> identifier: <span><span>NCT01029171</span><svg><path></path></svg></span></div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108151"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of menopausal symptoms with job-related stress and social support in Japanese school teachers","authors":"Yukie Matsuura,&nbsp;Toshiyuki Yasui","doi":"10.1016/j.maturitas.2024.108152","DOIUrl":"10.1016/j.maturitas.2024.108152","url":null,"abstract":"<div><h3>Objectives</h3><div>Being a school teacher is highly stressful. This study aimed to clarify the prevalence of menopausal symptoms and explore the association between these symptoms and job-related stress among Japanese school teachers.</div></div><div><h3>Study design</h3><div>A cross-sectional study was conducted among randomly selected elementary and junior high school teachers in Japan. Data from 284 teachers aged 45–60 years were analyzed.</div></div><div><h3>Main outcome measures</h3><div>Menopausal symptoms were measured using the Greene Climacteric Scale, and the Brief Job Stress Questionnaire was used to assess job stressors, social support, and job/family satisfaction. Associations between scores on the Greene Climacteric Scale and on the Brief Job Stress Questionnaire, and demographic information were analyzed.</div></div><div><h3>Results</h3><div>The most common menopausal symptom was “feeling tired or lacking in energy” (reported by 94.4 % of respondents). The total intensity of menopausal, psychological, and somatic symptoms was significantly correlated with the total level of job stress. Moderate correlations were found between depressive symptoms and job stress regarding suitable jobs, job control, and rewarding jobs, while weak correlations were evident between depressive symptoms and job stress regarding quantitative job overload, interpersonal conflict, and poor physical environment. Higher levels of perceived support from supervisors or co-workers and job satisfaction were associated with less severe psychological and somatic symptoms.</div></div><div><h3>Conclusions</h3><div>Most middle-aged school teachers felt tired or lacking in energy. Higher job-related stress and lower levels of support from supervisors or co-workers were correlated with more severe menopausal symptoms. A supportive work environment and stress management are essential for such teachers.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108152"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The ability of decline in intrinsic capacity to indicate the risk of mortality in older adults: A meta-analysis” [Maturitas 189 (2024) 108109]","authors":"Yidan Li ,&nbsp;Tingting Yang ,&nbsp;Xuedan Wang ,&nbsp;Xiang He ,&nbsp;Jianhui Dong ,&nbsp;Qiuxia Qian ,&nbsp;Xingxia Zhang ,&nbsp;Jie Zheng ,&nbsp;Xiangping Fan ,&nbsp;Yuxia Ma","doi":"10.1016/j.maturitas.2024.108144","DOIUrl":"10.1016/j.maturitas.2024.108144","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108144"},"PeriodicalIF":3.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross-sectional and longitudinal associations between fruit intake and cognitive performance: the Chinese Healthy Dance Study","authors":"Yuanyuan Li ,&nbsp;Shuai Chen ,&nbsp;Fengping Li ,&nbsp;Benchao Li ,&nbsp;Tingting Li ,&nbsp;Senli Deng ,&nbsp;Xiaoge Wang ,&nbsp;Shuang Rong","doi":"10.1016/j.maturitas.2024.108146","DOIUrl":"10.1016/j.maturitas.2024.108146","url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the association between fruit consumption and cognitive performance in middle-aged and older adults in China.</div></div><div><h3>Methods</h3><div>Participants were drawn from the Chinese Square Dance Cohort. The cross-sectional dataset included 4316 individuals, with their first visit from August 2020 to August 2023. The longitudinal dataset included 1465 participants, with their first visit from August 2020 to December 2021 and follow-up visits from August 2022 to December 2023. Fruit consumption was assessed using a food frequency questionnaire. Standardised neuropsychological assessments were used to measure composite z-scores of cognitive performance, and prevalent and incident mild cognitive impairment.</div></div><div><h3>Results</h3><div>In the cross-sectional analysis, higher quartiles of citrus fruit, drupe, berry, and tropical fruit consumption were associated with higher composite z-scores for cognitive performance and lower odds of prevalent mild cognitive impairment. In the longitudinal analysis, there was a positive association between higher quartiles of citrus fruit intake and the annual rate of change in the composite z-scores for cognitive performance; standardised regression coefficient (95 % confidence interval) for the highest compared with the lowest quartile was 0.05 (0.02–0.08). Moreover, an association between higher quartiles of citrus fruit intake and a lower risk of incident mild cognitive impairment was detected; in the comparison of the highest with the lowest quartile, the risk ratio (95 % confidence interval) was 0.56 (0.36–0.88).</div></div><div><h3>Conclusions</h3><div>The relationship between fruit consumption and cognition varies across the different categories of fruit. Cognitive benefits of citrus fruit consumption were found for middle-aged and older adults. Ascertaining this association might enhance comprehensive dietary recommendations for fruit consumption.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108146"},"PeriodicalIF":3.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain during menopause","authors":"Natalie H. Strand ,&nbsp;Ryan S. D'Souza ,&nbsp;Diego A. Gomez ,&nbsp;Madeline A. Whitney ,&nbsp;Sumedha Attanti ,&nbsp;Meredith A. Anderson ,&nbsp;Susan M. Moeschler ,&nbsp;Andrea L. Chadwick ,&nbsp;Jillian A. Maloney","doi":"10.1016/j.maturitas.2024.108135","DOIUrl":"10.1016/j.maturitas.2024.108135","url":null,"abstract":"<div><div>Menopause is a biological process marking the end of a woman's reproductive years, typically occurring between the ages of 45 and 55. While often associated with hot flashes, mood swings, and hormonal changes, pain is a frequently overlooked and under-addressed aspect of the menopausal experience. This review article explores the multifaceted nature of pain during menopause, and sheds light on its various manifestations and the factors contributing to its prevalence and severity. Pain during menopause may include musculoskeletal discomfort, headaches or migraines, and vulvovaginal pain. The etiology of these is intricate, involving hormonal fluctuations, psychosocial factors, and genetic predispositions. Fluctuations in estrogen and progesterone levels play a pivotal role in musculoskeletal pain and joint stiffness, and increase susceptibility to conditions such as osteoarthritis. Furthermore, mood disorders, stress, and sleep disturbances may exacerbate the perception of pain. Gender norms, as well as changes in reproductive capacity and societal views on aging, may adversely the impact the self-esteem of individuals undergoing menopause. These symptoms can significantly impact a woman's quality of life, underscoring the need for early identification and appropriate management strategies. This review article highlights the factors contributing to pain during menopause, evaluates the effects of hormones on menopausal pain, and investigates management strategies for pain during menopause, including both pharmacological and non-pharmacological approaches. It also emphasizes the need for further research to better understand the interplay of factors contributing to pain during menopause, in order to allow for more tailored and effective interventions. In understanding and addressing this often-neglected aspect of menopause, healthcare providers can enhance the overall wellbeing and quality of life for women transitioning through this natural life stage.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108135"},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal symptoms in breast cancer survivors on adjuvant endocrine therapy compared with those of menopausal women","authors":"Giorgia Asinaro ,&nbsp;Claudia Massarotti ,&nbsp;Anjeza Xholli ,&nbsp;Ambrogio P. Londero ,&nbsp;Matteo Lambertini ,&nbsp;Paola Anserini ,&nbsp;Lucia Del Mastro ,&nbsp;Angelo Cagnacci","doi":"10.1016/j.maturitas.2024.108143","DOIUrl":"10.1016/j.maturitas.2024.108143","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare menopausal symptoms of breast cancer survivors on adjuvant endocrine therapy with those of menopausal women.</div></div><div><h3>Study design</h3><div>In a retrospective nested case-control study menopausal symptoms were compared of breast cancer survivors in pre-, peri- or post-menopause at the time of diagnosis, on tamoxifen or an aromatase inhibitor, plus a gonadotrophin-releasing hormone analogue, if pre- or peri-menopausal, and age-matched control women either in the late peri-menopause, or in surgical or in physiological post-menopause on no hormone replacement therapy. Differences between women on tamoxifen and those on aromatase inhibitors were also evaluated. Weighted and non-weighted <em>t</em>-tests, chi-square tests, and linear or logistic regressions were applied as appropriate.</div></div><div><h3>Main outcome measures</h3><div>Score on the Greene's Climacteric Scale and so of its subscales evaluating vasomotor, anxiety, depression, somatisation and sexuality symptoms.</div></div><div><h3>Results</h3><div>A total of 99 breast cancer survivors (45 on tamoxifen, 54 on aromatase inhibitors) and 554 controls (173 in late perimenopause, 353 in natural and 28 in surgical menopause) were enrolled. The score on the Greene's Climacteric Scale was similar in cases and controls (means ± standard deviation) (21.3 ± 10.4 vs. 22.8 ± 11.5, <em>p</em> = 0.199), as were the subscale scores for vasomotor symptoms, anxiety, and somatisation. The depression score was lower (4.63 ± 3.3 vs. 5.98 ± 3.8; <em>p</em> = 0.001) in breast cancer survivors on adjuvant endocrine therapy, mainly due to a lower score of −2.132 (95 % confidence interval − 3.858/−0.407; <em>p</em> = 0.016) for users of aromatase inhibitors. The sexuality score was higher (1.76 ± 1.1 vs. 1.50 ± 1.1, <em>p</em> = 0.011) than in controls. Differences remained significant when corrected for age, menarche, body mass index, menopausal status (peri- or post-), type of menopause (natural, surgical), use of gonadotrophin-releasing hormone analogues, years of amenorrhea, smoking, alcohol use, and for breast radiotherapy, chemotherapy, tamoxifen or aromatase inhibitors. Among breast cancer survivors, women on aromatase inhibitors had lower scores for anxiety (5.75 ± 2.5vs.5.75 ± 2.5; <em>p</em> = 0.045) and depression (3.89 ± 2.5 vs. 5.13 ± 3.6; <em>p</em> = 0.046) than women on tamoxifen.</div></div><div><h3>Conclusions</h3><div>In breast cancer survivors, adjuvant therapy induces symptoms similar in type and intensity to those of symptomatic menopausal women. Compared with menopausal women, breast cancer survivors, particularly those on aromatase inhibitors, appear to experience less severe depressive symptoms.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108143"},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fall risk screening in older adults using the “CARE” frailty scale: The NuAge cohort results","authors":"Olivier Beauchet ,&nbsp;Jacqueline Matskiv ,&nbsp;Pierrette Gaudreau ,&nbsp;Gilles Allali ,&nbsp;Anne-Julie Vaillant-Ciszewicz ,&nbsp;Olivier Guerin ,&nbsp;Auriane Gros","doi":"10.1016/j.maturitas.2024.108134","DOIUrl":"10.1016/j.maturitas.2024.108134","url":null,"abstract":"<div><h3>Background</h3><div>“CARE” is an electronic health (e-health) application (app) which assesses frailty with its frailty module and risk of falls with its mobility module. This study examines and compares the risk of incident falls (<em>i.e.,</em> ≥1, ≥2 and severe falls) among older people in Quebec classified as “frail” and those classified as being at a high risk of falls by the CARE app.</div></div><div><h3>Methods</h3><div>A subset of men and women (<em>n</em> = 1151; 74.2 ± 4.2 years; 52.8 % female) who participated in the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge) were selected for this study. Pre-frail and frail states using the CARE frailty scale as well as high risk of falls estimated by CARE mobility module were determined at baseline. Pre-frail and frail states were merged in a single “frail state” group. Incident falls (<em>i.e.,</em> ≥1, ≥2 and severe falls) were annually recorded over a 3-year follow-up.</div></div><div><h3>Results</h3><div>Both CARE frail state (Odd ratio (OR) ≥1.89 with <em>P</em> ≥ 0.040) and high risk of falls estimated by the CARE mobility module (OR) ≥3.32 with <em>P</em> ≥ 0.023) were significantly associated with incident falls (<em>i.e.,</em> at least one fall) and recurrent falls (<em>i.e.,</em> at least two falls). A greater association with these fall outcomes was observed with the high risk of falls than with the frail state. No significant association between the high risk of falls and severe falls was found (OR = 1.71 with <em>P</em> = 0.227), whereas that was the case with frail state (OR = 3.08 with <em>P</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>Frail state determined by the CARE frailty module and high risk of falls determined by the CARE mobility module were both significantly associated with fall outcomes, a greater association being shown with the CARE high risk of falls and with CARE frail state for severe falls. These results suggest that the CARE app may be useful for screening older people for the risk of falls.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"191 ","pages":"Article 108134"},"PeriodicalIF":3.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}