Maturitas最新文献

{"title":"Relationship between the use of high-risk perioperative medications and postoperative cardiac complications in older adults undergoing spinal surgery: A retrospective cohort study","authors":"Jianghua Shen ,&nbsp;Xiangyao Sun ,&nbsp;Yanqi Chu ,&nbsp;Chao Kong ,&nbsp;Chaodong Wang","doi":"10.1016/j.maturitas.2025.108255","DOIUrl":"10.1016/j.maturitas.2025.108255","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the association between high-risk perioperative medications (HRPOMs) and postoperative cardiac complications in older adults undergoing spinal surgery.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included patients aged 75 years and older who underwent elective spinal surgery under general anesthesia between January 2020 and December 2022. We collected data on demographic characteristics, comorbidities, preoperative hemoglobin level, intraoperative details and postoperative cardiac complications. Univariate and multivariate regression analyses were conducted to identify risk factors for postoperative cardiac complications.</div></div><div><h3>Results</h3><div>Of 427 patients who underwent spinal surgery included in the study, 301 were found to be using high-risk cardiac medications. Postoperatively, 28 patients experienced cardiac complications, an incidence rate of 6.6 %. Multivariate analysis identified several significant predictors of these complications: lower preoperative serum hemoglobin levels (adjusted odds ratio (AOR) = 0.969; <em>p</em> = 0.017), intraoperative blood loss (AOR = 1.124; <em>p</em> = 0.010) and preoperative long-term use of beta-blockers (AOR = 2.708; <em>p</em> = 0.026). In particular, a failure to resume the use of beta-blockers after surgery (AOR = 159.942; p&lt;0.001) seems to be the most significant factor.</div></div><div><h3>Conclusion</h3><div>In summary, our study highlights important risk factors for postoperative cardiac complications in older adults undergoing spinal surgery, especially the standardized use of HRPOMs in the perioperative period. Future research should aim to validate these findings through prospective studies and ensure the safety of perioperative medications for patients.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108255"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life satisfaction as a protective factor against frailty among Japanese adults aged 60 and older: A cohort study","authors":"Kazuya Fujii ,&nbsp;Kenji Harada ,&nbsp;Satoshi Kurita ,&nbsp;Masanori Morikawa ,&nbsp;Chiharu Nishijima ,&nbsp;Daisuke Kakita ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.maturitas.2025.108256","DOIUrl":"10.1016/j.maturitas.2025.108256","url":null,"abstract":"<div><h3>Objectives</h3><div>Subjective well-being is linked to healthy aging as it decreases disease-related risk factors. Frailty is associated with biological factors such as inflammatory markers. However, the relationship between life satisfaction, a type of subjective well-being, and the onset of frailty is not sufficiently clear. This study investigated the relationship between life satisfaction and the onset of frailty among Japanese adults aged 60 years and older.</div></div><div><h3>Design</h3><div>A prospective cohort study was conducted.</div></div><div><h3>Setting and participants</h3><div>The sample comprised 1760 individuals aged ≥60 years living in Japan.</div></div><div><h3>Methods</h3><div>A baseline assessment was followed by a further assessment 2.5 years later. The main outcome, frailty, was defined as a score of 7 or more on the Kihon checklist. The independent variable was score on a life satisfaction scale. A logistic regression model was used to examine the relationship between the onset of frailty and quartiles on the life satisfaction scale, and odds ratios and 95 % confidence intervals were calculated.</div></div><div><h3>Results</h3><div>A total of 216 participants (12.2 %) developed frailty during the follow-up. Score on the life satisfaction scale at baseline for all participants was 39.7 ± 5.0. The odds ratio (95 % confidence intervals) for life satisfaction scale quartiles for the onset of frailty was 0.50 (0.33–0.75) for the Q2 group, 0.45 (0.28–0.72) for the Q3 group, and 0.43 (0.26–0.67) for the Q4 group, compared with the Q1 (lowest life satisfaction score) group.</div></div><div><h3>Conclusions and implications</h3><div>The results suggest that high life satisfaction is a protective factor against frailty. Increasing the life satisfaction of Japanese adults aged 60 years and older may contribute to the prevention of frailty.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108256"},"PeriodicalIF":3.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply to Yu-Hsiang Lin et al.","authors":"Rebecca Zurbuchen ,&nbsp;Anna von Däniken ,&nbsp;Heidrun Janka ,&nbsp;Michael von Wolff ,&nbsp;Petra Stute","doi":"10.1016/j.maturitas.2025.108253","DOIUrl":"10.1016/j.maturitas.2025.108253","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"197 ","pages":"Article 108253"},"PeriodicalIF":3.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of chair stand performance with all-cause and cardiovascular mortality in older adults with hypertension: A 28-country study","authors":"Ana Polo-López ,&nbsp;Rubén López-Bueno ,&nbsp;Joaquín Calatayud ,&nbsp;Rodrigo Núñez-Cortés ,&nbsp;Luis Suso-Martí ,&nbsp;Lars Louis Andersen","doi":"10.1016/j.maturitas.2025.108248","DOIUrl":"10.1016/j.maturitas.2025.108248","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the prospective association of chair stand performance with all-cause and cardiovascular mortality in older adults with hypertension.</div></div><div><h3>Methods</h3><div>From the Survey of Health, Ageing and Retirement in Europe (SHARE) study, we included 18,252 adults aged 50 years or more with hypertension from 28 countries (27 European countries and Israel). Chair stand performance was assessed by the time taken to complete five chair stands. We used time-varying Cox regression with restricted cubic splines to determine the prospective association of chair stand time with all-cause and cardiovascular mortality, controlling for various confounders.</div></div><div><h3>Key results</h3><div>Over a mean follow-up of 3.5 years, 648 participants died, with 243 deaths attributed to cardiovascular disease. Using the median chair stand time (11 s) as a reference, both faster and slower times were associated with altered mortality risk in a curvilinear fashion. For all-cause mortality, the 10th percentile of chair stand time (7 s) showed a hazard ratio (HR) of 0.71 (95 % CI 0.60–0.85), while the 90th percentile (19 s) showed a HR of 1.20 (95 % CI 1.10–1.32). For cardiovascular mortality, the 10th percentile showed a subdistribution hazard ratio (SHR) of 0.72 (95 % CI 0.53–0.97), while the 90th percentile showed a SHR of 1.28 (95 % CI 1.10–1.48).</div></div><div><h3>Conclusion</h3><div>Chair stand performance is gradually and inversely associated with risk of all-cause and cardiovascular mortality in older adults with hypertension. These findings highlight the potential of the chair stand test as a prognostic measure.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108248"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial function as a potential biomarker for biological aging","authors":"Yu-Hsiang Lin ,&nbsp;Kuo-Jen Lin ,&nbsp;Tsung-Hsing Chen","doi":"10.1016/j.maturitas.2025.108247","DOIUrl":"10.1016/j.maturitas.2025.108247","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108247"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of healthy ageing: Wearables in public health, disease prevention and healthcare","authors":"Marilyne Menassa ,&nbsp;Ilona Wilmont ,&nbsp;Sara Beigrezaei ,&nbsp;Arno Knobbe ,&nbsp;Vicente Artola Arita ,&nbsp;Jose F. Valderrama V ,&nbsp;Lara Bridge ,&nbsp;W.M. Monique Verschuren ,&nbsp;Kirsten L. Rennie ,&nbsp;Oscar H. Franco ,&nbsp;Frans van der Ouderaa","doi":"10.1016/j.maturitas.2025.108254","DOIUrl":"10.1016/j.maturitas.2025.108254","url":null,"abstract":"<div><div>Wearables have evolved into accessible tools for sports, research, and interventions. Their use has expanded to real-time monitoring of behavioural parameters related to ageing and health. This paper provides an overview of the literature on wearables in disease prevention and healthcare over the life course (not only in the older population), based on insights from the Future of Diagnostics Workshop (Leiden, January 2024).</div><div>Wearable-generated parameters include blood glucose, heart rate, step count, energy expenditure, and oxygen saturation. Integrating wearables in healthcare is protracted and far from mainstream implementation, but promises better diagnosis, biomonitoring, and assessment of medical interventions.</div><div>The main lifestyle factors monitored directly with wearables or through smartphone applications for disease prevention include physical activity, energy expenditure, gait, sleep, and sedentary behaviour. Insights on dietary consumption and nutrition have resulted from continuous glucose monitors. These factors are important for healthy ageing due to their effect on underlying disease pathways.</div><div>Inclusivity and engagement, data quality and ease of interpretation, privacy and ethics, user autonomy in decision making, and efficacy present challenges to but also opportunities for their use, especially by older people. These need to be addressed before wearables can be integrated into mainstream medical and public health strategies. Furthermore, six key considerations need to be tackled: 1) engagement, health literacy, and compliance with personalised feedback, 2) technical and standardisation requirements for scalability, 3) accountability, data safety/security, and ethical concerns, 4) technological considerations, access, and capacity building, 5) clinical relevance and risk of overdiagnosis/overmedicalisation, and 6) the clinician's perspective in implementation.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108254"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in body size associated with all-cause mortality in an older Chinese population","authors":"Dechen Liu,&nbsp;Jinjin Wang,&nbsp;Yuqi Niu,&nbsp;Guoli Yan","doi":"10.1016/j.maturitas.2025.108252","DOIUrl":"10.1016/j.maturitas.2025.108252","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence of an association between a change in body size and the risk of all-cause mortality is limited among older populations. We explored the association of a change in body size over three years with the risk of all-cause mortality in an older Chinese population.</div></div><div><h3>Methods</h3><div>A total of 5134 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were recruited. Cox proportional-hazards models were used to assess the association of changes in body mass index (BMI) and body fat percentage (BF%) with risk of all-cause mortality, using hazard ratios (HRs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Of the 5134 participants (median age, 81 years; 2716 women [52.90%]), 1494 deaths were observed over a median of 4.08 years of follow-up. Compared with participants with stable body size (change within 5%), those with more than a 10% decrease in BMI or BF% had 36% and 46% higher risks, respectively, of all-cause mortality (HR = 1.36, 95% CI: 1.17–1.59; and HR = 1.46, 95% CI: 1.25–1.72); also, those with more than a 10% increase in BMI or BF% had 22% and 17% higher risks of all-cause mortality (HR = 1.22, 95% CI: 1.05–1.41; and HR = 1.17, 95% CI: 1.02–1.35).</div></div><div><h3>Conclusions</h3><div>This prospective cohort study of older adults suggests that a dramatic change in body size was positively associated with a higher risk of all-cause mortality. More attention should be paid to the effects of a dramatic change in body size, particularly a dramatic decrease in body size, among the Chinese population.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108252"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and performance of the new Guide for the Assessment of Menopausal Symptoms (GAMS) scale, based on the Greene Climacteric Scale: A population survey of French women","authors":"Alexandre Vallée ,&nbsp;Thomas Bozzo ,&nbsp;Maxence Arutkin ,&nbsp;Jean-Marc Ayoubi ,&nbsp;Pierre-François Ceccaldi","doi":"10.1016/j.maturitas.2025.108249","DOIUrl":"10.1016/j.maturitas.2025.108249","url":null,"abstract":"<div><h3>Objective</h3><div>The validity of the Greene Climacteric Scale (GCS) is supported by evidence demonstrating a strong correlation with other measures of menopausal symptoms and quality of life. However, this score, developed 60 years ago, may not be fully applicable the current menopausal population. The purpose of this study was to evaluate the validity of the GCS in a French population and to determine whether an alternative construction of the scale could improve its performance. This led to the development of a new tool: the Guide for the Assessment of Menopausal Symptoms (GAMS) scale.</div></div><div><h3>Methods</h3><div>The 21 questions of the GCS were distributed to French women via social media. The performance of the GCS score in identifying menopausal status was ascertained. Subsequently, the GAMS scale was developed using a training dataset and was validated on a separate dataset.</div></div><div><h3>Results</h3><div>The training dataset included data from 14,518 participants, of whom 3722 (26.64 %) were classified as menopausal. The validation dataset consisted of 3629 participants, of whom 852 (23.48 %) were menopausal. The GCS demonstrated an AUC of 0.53, with a median score of 20 [IQR: 14–27] for menopausal cases and a maximum probability of correct classification of 38 %. In comparison, the GAMS scale achieved an AUC of 0.63, with a median score of 4 [IQR: 2–7] and a maximum probability of correct classification of 70 %.</div></div><div><h3>Conclusion</h3><div>The performance of the GCS in identifying menopausal status is low. Applying weighting coefficients in the GAMS scale improves its performance. Further research is essential to develop tailored and specific menopausal scales that better address women's symptoms and improve their care.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108249"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heritability of bone mineral density among Japanese women: A twin study","authors":"Soichiro Saeki ,&nbsp;Rie Tomizawa ,&nbsp;Kaori Minamitani ,&nbsp;Ken Nakata ,&nbsp;Osaka Twin Research Group ,&nbsp;Chika Honda","doi":"10.1016/j.maturitas.2025.108251","DOIUrl":"10.1016/j.maturitas.2025.108251","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density.</div></div><div><h3>Methods</h3><div>The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density.</div></div><div><h3>Results</h3><div>The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72).</div></div><div><h3>Conclusions</h3><div>Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108251"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating skeletal wellness after breast cancer","authors":"Eleni Armeni","doi":"10.1016/j.maturitas.2025.108250","DOIUrl":"10.1016/j.maturitas.2025.108250","url":null,"abstract":"<div><div>Breast cancer is the leading cause of death in the female population. Hormone receptor-positive cancers are usually treated with surgery in combination with endocrine therapy. The latter is known to lower estrogen levels, contributing, therefore, to loss of bone density (BMD) and higher risk of fracture. Bone-modifying agents (BMAs) can regulate the bone-related adverse effects of cancer treatment. In premenopausal women, intravenous zoledronate effectively prevents bone loss. However, the evidence regarding its ability to reduce disease recurrence remains inconclusive. In postmenopausal women, denosumab demonstrates the most substantial evidence for fracture prevention, supported by one well-powered randomized controlled trial, but has not been shown to confer anticancer benefits. While bisphosphonates effectively prevent and reduce clinical vertebra fractures, their impact on overall fracture risk is unclear. In clinical practice, management of bone health in this group of patients starts with stratification for the risk of fracture. This can be done using the FRAX algorithm; measurements of bone mineral density can help to optimize stratification for individuals at higher fracture risk. Caution is advised when interpreting the results, as the FRAX algorithm has been considered to underestimate the true fracture risk in this population, given that the algorithm has not been adjusted for the effect of anti-cancer agents. Nowadays, clodronate, ibandronate, and zoledronic acid are recommended for bone protection in this group of patients, while denosumab is not. Further research is required to highlight the optimal BMA according to patient characteristics.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"196 ","pages":"Article 108250"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}