Maturitas最新文献

{"title":"Cognitive and behavioral weight management strategies during the menopausal transition: Insights from the Menopause and Weight Loss (ME-WEL) project","authors":"Mafalda Leitão ,&nbsp;Faustino R. Pérez-López ,&nbsp;João Marôco ,&nbsp;Filipa Pimenta","doi":"10.1016/j.maturitas.2024.108060","DOIUrl":"10.1016/j.maturitas.2024.108060","url":null,"abstract":"<div><h3>Objective</h3><p>Most women experience weight gain during the menopausal transition, often attributed to behavioral factors. Nevertheless, some women successfully maintain a healthy weight during this phase. This study aims to identify the successful cognitive and behavioral weight management strategies employed by postmenopausal women who effectively maintained a healthy weight during the menopausal transition (from premenopause to postmenopause).</p></div><div><h3>Method</h3><p>Semi-structured interviews were conducted with 31 Portuguese postmenopausal women, aged 45–65 years (<em>mean and standard deviation</em> 54.06 <em>±</em> 5.51) who successfully maintained a healthy weight (body mass index: 18.5 kg/m²–24.9 kg/m²) during the menopausal transition. The interviews were conducted via telephone <em>(n = 29)</em> and Zoom <em>(n = 2),</em> based on the participant's preference, and ranged from 11 to 52 min <em>(22.06</em> ± 9.95). Using <em>MAXQDA</em> software, deductive-dominant content analysis of the interviews was performed. The <em>Interface of R for the Multidimensional Analyses of Texts and Questionnaire</em> software was used for lexical analysis.</p></div><div><h3>Results</h3><p>The qualitative analysis of <em>cognitive and behavioral strategies for successful weight management</em> yielded 17 categories and 37 sub-categories. Effective cognitive and behavioral strategies (e.g., planning content, stimulus control, support: help from others) were identified, mostly aligning with the Oxford Food and Activity Behaviors Taxonomy. Five new categories emerged: dietary choices, intuitive eating, food literacy, psychological self-care, and effortful inhibition.</p></div><div><h3>Conclusion</h3><p>Knowing effective cognitive and behavioral weight management strategies for menopausal women is relevant, especially considering their status as a high-risk group. This knowledge provides a valuable guide for designing weight management interventions, emphasizing the essential role of behavioral change.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001555/pdfft?md5=4ed29ce49cf6d5156b4ac71051ba9008&pid=1-s2.0-S0378512224001555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging frailty and burns: Defining acute burn injury as a cause of long-term frailty","authors":"Adriana C. Panayi ,&nbsp;David N. Herndon ,&nbsp;Ludwik Branski ,&nbsp;Folke Sjöberg ,&nbsp;Gabriel Hundeshagen","doi":"10.1016/j.maturitas.2024.108061","DOIUrl":"10.1016/j.maturitas.2024.108061","url":null,"abstract":"<div><p>Although our understanding of frailty has evolved and multiple indices have been developed, the impact of burn injuries on long-term health has been overlooked. With over 11 million annual cases globally, burns affect all demographics, although socioeconomic disparities are evident. With survival rates improved, morbidity among survivors is becoming more evident, and shows similarity to predictors of frailty. Some of the chronic effects of burns, including mental health issues and increased risks of disease, mirror frailty markers. Studies show burn survivors have lower life expectancy, independent of burn severity. Integrating burn history into frailty assessments and establishing specialized long-term care can mitigate this frailty risk. Improved interdisciplinary follow-up and research are vital for enhancing burn survivors' quality of life and longevity.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between frailty, genetic predisposition, and chronic kidney disease risk in middle-aged and older adults: A prospective cohort study","authors":"Honghao Yang ,&nbsp;Zhenhua Li ,&nbsp;Yixiao Zhang ,&nbsp;Qing Chang ,&nbsp;Jinguo Jiang ,&nbsp;Yashu Liu ,&nbsp;Chao Ji ,&nbsp;Liangkai Chen ,&nbsp;Yang Xia ,&nbsp;Yuhong Zhao","doi":"10.1016/j.maturitas.2024.108059","DOIUrl":"10.1016/j.maturitas.2024.108059","url":null,"abstract":"<div><h3>Objectives</h3><p>Cross-sectional evidence has shown that frailty is highly prevalent in patients with chronic kidney disease (CKD). However, there is limited evidence of the longitudinal associations between frailty, genetic predisposition to CKD, and the risk of CKD in the general population. Therefore, this study aimed to examine such associations among participants in the UK Biobank.</p></div><div><h3>Study design</h3><p>This is a prospective cohort study included 370,965 middle-aged and older adults from the UK Biobank. Physical frailty was assessed using a modified version of the Fried phenotype classification. A weighted genetic risk score was built using 263 variants associated with estimated glomerular filtration rate.</p></div><div><h3>Main outcome measures</h3><p>Incident CKD was identified from hospital inpatient records.</p></div><div><h3>Results</h3><p>Over a median follow-up of 12.3 years, we documented a total of 11,121 incident CKD cases. Time-dependent Cox proportional hazards regression models indicated that individuals with frailty (hazard ratio [HR]: 1.94, 95 % confidence interval [CI]: 1.81–2.08) and pre-frailty (HR: 1.27, 95 % CI: 1.22–1.33) had an increased risk of developing CKD, compared with non-frail individuals. No significant interaction between frailty and genetic risk score was observed (<em>P</em> for interaction = 0.41). The highest risk was observed among the individuals with high genetic risk and frailty (HR: 2.31, 95 % CI: 2.00–2.68).</p></div><div><h3>Conclusion</h3><p>Our results demonstrated that frailty and pre-frailty were associated with increased risk of incident CKD in middle-age and older adults, regardless of genetic risk of CKD. Our study underscores the importance of frailty screening and intervention as a potential strategy to prevent CKD. Future clinical trials are needed to validate our findings.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the health needs of women with female genital mutilation going through menopause?","authors":"Aini Kamal ,&nbsp;Sarian Kamara ,&nbsp;Rajvinder Khasriya PhD MRCOG ,&nbsp;Sohier Elneil PhD FRCOG ,&nbsp;Louise Newson MCRP FRCGP ,&nbsp;Daniel Reisel DPhil MRCOG","doi":"10.1016/j.maturitas.2024.108058","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108058","url":null,"abstract":"<div><p>Female genital mutilation is widely recognised as a practice that causes grave, permanent damage to the genital anatomy and function. The literature has documented its impact on physical, sexual, emotional, and mental wellbeing, and this has informed the development of guidelines and recommendations for managing women with female genital mutilation. There has, though, been little, if any, focus on how women with female genital mutilation experience menopause. A literature search did not return any published research on the topic and there are currently no clinical guidelines for managing the menopause in women who have undergone female genital mutilation. This review calls attention to this gap by exploring the clinical implications that the loss of natural hormones has on the vulvovaginal tissues, as well as on urogenital and sexual function. Psychological aspects of the experience of women with female genital mutilation going through menopause are also explored, as well as common barriers they face in accessing adequate healthcare. Finally, we offer a set of recommendations for clinical practice, including the need to improve current care pathways, and potential directions for future research.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001531/pdfft?md5=5f24887e251f7a382a083bb7f3f08292&pid=1-s2.0-S0378512224001531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and integrative oncology interventions for cancer-related fatigue and sleep disturbances","authors":"Carolyn Ee ,&nbsp;Shelley Kay ,&nbsp;Amy Reynolds ,&nbsp;Nicole Lovato ,&nbsp;Judith Lacey ,&nbsp;Bogda Koczwara","doi":"10.1016/j.maturitas.2024.108056","DOIUrl":"10.1016/j.maturitas.2024.108056","url":null,"abstract":"<div><p>Fatigue, insomnia and sleep disturbances are common after cancer diagnosis, and have a negative impact on quality of life and function. This narrative review synthesised evidence on lifestyle and integrative oncology interventions for cancer-related fatigue, insomnia and sleep disturbances in cancer survivors. There is strong evidence in support of aerobic and strength exercise for the relief of cancer-related fatigue. Yoga, massage therapy, acupuncture, Tai Chi and qigong can also be recommended for cancer-related fatigue. The evidence on yoga, acupuncture and massage therapy for sleep disturbances in cancer is mixed, while exercise appears to have a modest favourable effect. There is insufficient evidence on nutrient supplements or dietary interventions for cancer-related fatigue or insomnia and other sleep disturbances after cancer. Beyond alleviating cancer-related fatigue and insomnia-related symptoms, integrative oncology and lifestyle interventions have potential to effect multiple other benefits, such as improvement in symptoms such as pain and menopausal symptoms. There is a need for well-designed randomised controlled trials of interventions, particularly in the areas of diet and nutrient supplements, and for implementation studies of interventions already supported by evidence.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001518/pdfft?md5=c72c31bb58a20ef7ccae49174676ea5e&pid=1-s2.0-S0378512224001518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of handgrip strength asymmetry and weakness with cognitive function: a nationally representative cohort study","authors":"Youyou Zhang ,&nbsp;Rui Zhu ,&nbsp;Liru Ge ,&nbsp;Xiaoyue Zhang ,&nbsp;Dalong Tian ,&nbsp;Faming Pan ,&nbsp;Mengmeng Wang ,&nbsp;Guoqi Cai","doi":"10.1016/j.maturitas.2024.108057","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108057","url":null,"abstract":"<div><h3>Objective</h3><p>To describe the association of handgrip strength asymmetry and weakness with cognitive function among Chinese middle-aged and older adults.</p></div><div><h3>Study design</h3><p>We used data from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study. Handgrip strength was measured at baseline. Handgrip strength asymmetry was defined on the basis of the ratio of handgrip strength of the non-dominant hand to that of the dominant hand (i.e. non-dominant/dominant): a ratio of &lt;0.9 defined as dominant handgrip strength asymmetry and &gt;1.1 as non-dominant handgrip strength asymmetry. Weakness was defined as a handgrip strength of &lt;28 kg for males or &lt;18 kg for females.</p></div><div><h3>Main outcome measures</h3><p>Cognitive function with its two core dimensions (episodic memory and mental status) at each wave was assessed and standardized.</p></div><div><h3>Results</h3><p>9333 participants (48.3 % female, age 58.2 ± 9.0 years) were included. Non-dominant but not dominant handgrip strength asymmetry was significantly associated with poorer cognitive function at baseline (β = −0.121, −0.092, and −0.132 for mental status, episodic memory, and global cognition, respectively). In longitudinal analyses over 2 years, dominant handgrip strength asymmetry significantly slowed cognitive decline (β = −0.078 and −0.069 for mental status and global cognition, respectively), and non-dominant handgrip strength asymmetry accelerated cognitive decline (β = 0.053 and 0.043 for episodic memory and global cognition, respectively). Weakness was associated with poorer cognitive function at baseline and cognitive decline over 2, 4, and 7 years (all <em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>In middle-aged and older adults, non-dominant handgrip strength asymmetry and weakness were associated with poorer cognitive function and predicted accelerated cognitive decline. Dominant handgrip strength asymmetry may be beneficial for maintaining cognitive function.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worse sleep architecture but not self-reported insomnia and sleepiness is associated with higher cortisol levels in menopausal women","authors":"Nima Sahola ,&nbsp;Elena Toffol ,&nbsp;Nea Kalleinen ,&nbsp;Päivi Polo-Kantola","doi":"10.1016/j.maturitas.2024.108053","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108053","url":null,"abstract":"<div><h3>Objective</h3><p>Worsening of sleep quality during menopause is well recognized. However, the underlying hormonal regulation is insufficiently described. In this study, we evaluated associations between sleep and cortisol levels.</p></div><div><h3>Study design</h3><p>Seventeen perimenopausal and 18 postmenopausal women were enrolled in a three-night sleep study. Diurnal blood sampling was performed during the third night and the following day.</p></div><div><h3>Main outcome measures</h3><p>Self-reported insomnia and sleepiness were evaluated with the Basic Nordic Sleep Questionnaire and sleep architecture with all-night polysomnography. Diurnal cortisol samples were collected at 20-min intervals. Correlation analyses and generalized linear models adjusted by age, body mass index, vasomotor symptoms and depressive symptoms were conducted.</p></div><div><h3>Results</h3><p>In correlation analyses, self-reported insomnia and sleepiness were not associated with cortisol levels. Lower sleep efficiency, slow-wave sleep and stage 1 percentages, number of slow-wave sleep and of rapid-eye-movement (REM) periods, longer slow-wave sleep latency and higher wake after sleep onset percentage were associated with higher cortisol levels (all <em>p</em> &lt; 0.05). Further, lower slow-wave sleep percentage and longer slow-wave sleep latency correlated with steeper daytime cortisol slope (i.e. day cortisol decrease, both p &lt; 0.05). In adjusted generalized linear models, lower sleep efficiency and number of rapid-eye-movement periods as well as higher wake after sleep onset percentage correlated with higher cortisol levels; lower slow-wave sleep percentage correlated with higher cortisol awakening response.</p></div><div><h3>Conclusions</h3><p>Worse sleep architecture but not worse self-reported insomnia and sleepiness was associated with higher cortisol levels. This is important for understanding sleep in women, especially during the menopausal period.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378512224001488/pdfft?md5=67cd85de95113c2abd121a64accd74c4&pid=1-s2.0-S0378512224001488-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for recovery after work and associated risk factors in working menopausal women","authors":"Philippe Kiss ,&nbsp;Herman Depypere ,&nbsp;Marc De Meester ,&nbsp;Ilse Vingerhoets ,&nbsp;Marjolijn Van Hoecke ,&nbsp;Lutgart Braeckman","doi":"10.1016/j.maturitas.2024.108054","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108054","url":null,"abstract":"<div><h3>Objectives</h3><p>To explore relationships between ‘need for recovery’ (NFR), a strong predictor of burnout, and menopause symptoms and to identify work-related factors that are associated with a high NFR in Belgian menopausal women.</p></div><div><h3>Study design</h3><p>760 menopausal women took part in a cross-sectional questionnaire study. NFR, presence of menopause symptoms, job type, age category, work activity, physical workload, psychosocial and physical work environment, balance of work and private life and the opportunity to discuss menopause at work were assessed.</p></div><div><h3>Main outcome measures</h3><p>Uni- and multivariate logistic regression analyses were used to calculate the odds ratios for the presence of a high NFR.</p></div><div><h3>Results</h3><p>Of menopausal women currently experiencing menopause symptoms, 53.3 % reported problems while performing their work. The overall prevalence of a high NFR in menopausal women was 41.2 %. Women who experienced problems at work had the highest prevalence of a high NFR (61.1 %), and constituted a separate risk group for having a high NFR (OR 3.31 vs. never symptoms; 95%CI 1.72–6.38). The following factors were significantly associated with a high NFR: poor balance of work and private life (OR 7.89; 95%CI 4.32–14.39), physical workload (OR 1.17; 95%CI 1.08–1.28), discomfort from cognitive demands (OR 1.17; 95%CI 1.09–1.26), organizational justice (OR 0.86; 95%CI; 0.78–0.94), and social support from colleagues (OR 0.87; 95%CI 0.79–0.96).</p></div><div><h3>Conclusions</h3><p>Maintaining a good balance of work and private life, reducing physical workload, addressing discomfort from cognitive work demands and assuring a fair work distribution are measures that require a culture where open and easy discussion about menopause is possible.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overactive bladder and cognitive impairment in middle-aged women: A cross-sectional study","authors":"Jungeun Park ,&nbsp;Yoosoo Chang ,&nbsp;Hye Rin Choi ,&nbsp;Jae Heon Kim ,&nbsp;Sang Won Seo ,&nbsp;Hui Jin Ryu ,&nbsp;Yoosun Cho ,&nbsp;Chanmin Kim ,&nbsp;Ria Kwon ,&nbsp;Ga-Young Lim ,&nbsp;Jiin Ahn ,&nbsp;Kye-Hyun Kim ,&nbsp;Hoon Kim ,&nbsp;Yun Soo Hong ,&nbsp;Di Zhao ,&nbsp;Juhee Cho ,&nbsp;Eliseo Guallar ,&nbsp;Hyun-Young Park ,&nbsp;Seungho Ryu","doi":"10.1016/j.maturitas.2024.108042","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108042","url":null,"abstract":"<div><h3>Background</h3><p>Overactive bladder (OAB) is a common condition in middle-aged and older women. It has been reported to be potentially linked to cognitive decline, particularly in older adults. This study investigated the association between OAB symptoms and cognitive impairment in middle-aged women.</p></div><div><h3>Materials and methods</h3><p>This cross-sectional study had a sample of 1652 women (mean age 49.3 ± 2.8 years) who were not taking medication for either urinary tract infection or OAB. OAB symptoms and cognitive function were evaluated by self-administered questionnaires: the Overactive Bladder Symptom Score and the Alzheimer's disease 8. Logistic regression models estimated prevalence ratios (PRs) with 95 % confidence intervals (CI) for cognitive impairment according to the presence/absence of OAB. Mediation analyses assessed the impact of poor sleep quality on this association.</p></div><div><h3>Results</h3><p>Cognitive impairment was more prevalent in women with OAB than in those without OAB (multivariable-adjusted PR: 1.88 [95 % CI: 1.52–2.24]). Women experiencing nocturia (≥twice a night), urinary urgency at least once a week, and urgency urinary incontinence at least once a week had multivariable-adjusted PRs (95 % CI) for cognitive impairment of 2.08 (1.50–2.65), 2.12 (1.66–2.58), and 1.75 (1.17–2.34), respectively. Poor sleep quality mediated 10.81 % [95 % CI: 4.55–19.44 %] of the relationship between OAB and cognitive impairment.</p></div><div><h3>Conclusions</h3><p>Among middle-aged women not taking OAB medications, OAB symptoms were associated with cognitive impairment, partly because of poor sleep quality. Further research is needed to determine whether early screening of patients with OAB can help identify those susceptible to cognitive impairment associated with OAB medication and if preventive measures should be targeted at this group.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and early treatment for osteoporosis: Who are we missing under age 65?","authors":"Alyssa K. Ishimoto ,&nbsp;Amit A. Shah","doi":"10.1016/j.maturitas.2024.108044","DOIUrl":"https://doi.org/10.1016/j.maturitas.2024.108044","url":null,"abstract":"<div><p>For women under age 65, varying recommendations and the need to apply clinical risk calculators can lead to underscreening for osteoporosis. The resulting undertreatment may lead to a risk of osteoporotic fractures with significant morbidity and impact on functional status. Factors that must be considered when deciding to screen a woman under age 65 include a history of fragility fractures, race, family history, body mass index, smoking, high alcohol use, and secondary causes of osteoporosis. Secondary causes of osteoporosis are much more common in younger women. These include common conditions such as glucocorticoid use, hyperthyroidism, hypogonadism, chronic kidney disease, diabetes, anticonvulsant use, rheumatoid arthritis, malabsorption, and a history of anorexia nervosa. The reasons why these conditions confer an increased risk of osteoporosis are discussed. Recommendations are provided for the clinician to be aware of when screening women under age 65 for osteoporosis and initiating treatment when indicated.</p></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}