Journal of Sexual Medicine最新文献

{"title":"Persistent genital arousal disorder following urinary tract infection: a case report.","authors":"Meltem H Şimşek, Ulaş Korkmaz","doi":"10.1093/jsxmed/qdaf124","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf124","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and reproductive health practitioners' attitudes and knowledge regarding transgender, gender diverse, and non-binary patients: a mixed-method systematic review.","authors":"Gianluca Cruciani, Maria Quintigliano, Selene Mezzalira, Cristiano Scandurra, Nicola Carone","doi":"10.1093/jsxmed/qdaf115","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf115","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective and comparative evaluation of a male masturbation device for premature ejaculation-functional outcomes, safety, and satisfaction assessment: a pilot study.","authors":"Manuel Alonso-Isa, Borja García-Gómez, Esther García-Rojo, Elena Peña-Vallejo, Maria Del Prado Caro-González, Silvia Juste-Álvarez, Cristina Calzas-Montalvo, Raquel Sopeña-Sutil, Alfredo Rodríguez-Antolín, Javier Romero-Otero","doi":"10.1093/jsxmed/qdaf090","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf090","url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation (PE) is a common sexual dysfunction that negatively impacts the quality of life and relationships for men.</p><p><strong>Aim: </strong>To compare the effectiveness, side effects, and satisfaction between a novel cognitive-behavioral therapy based on sphincter control training (SCT) supported by a mechanical masturbation device and dapoxetine, a pharmacological treatment for PE.</p><p><strong>Methods: </strong>A crossover study with 20 male patients diagnosed with PE was designed. Participants were randomly assigned to start with an 8-week cognitive-behavioral therapy program supported by a masturbation device or an 8-week treatment with dapoxetine (60 mg). After a 2-week washout time, treatments were crossed. Effectiveness was measured through intravaginal ejaculation latency time (IELT), Premature Ejaculation Diagnostic Tool (PEDT) scores, and the International Index of Erectile Function. Satisfaction rates were measured using the Erectile Dysfunction Inventory of Treatment Satisfaction scale and Likert scale. Adverse effects were recorded for both treatments.</p><p><strong>Outcomes: </strong>Changes in IELT, PEDT scores, satisfaction rates, and side effects.</p><p><strong>Results: </strong>In the randomized phase, SCT + device demonstrated superior outcomes compared to dapoxetine for PEDT scores: 15.2 (SD = 1.7) vs 18.4 (SD = 2.6), P = .01; though IELT improvements were comparable: 111.7 (SD = 56.7) seconds vs 91.8 (SD = 77.8) seconds, P = .20. After crossover, patients switching from dapoxetine to SCT + device achieved significantly greater IELT 171.8 (SD = 148.8) seconds vs 76.7 (SD = 37.1) seconds, P = .02; and better PEDT scores: 14.6 (SD = 2.7) vs 17.7 (SD = 2.7), P = .04. Notably, dapoxetine underperformed relative to historical data. Treatment satisfaction was markedly higher with SCT + device: 64.9% (SD = 9.3) vs 33.3% (SD = 20.7), P = .003; with fewer adverse effects (25% vs 60%).</p><p><strong>Clinical implications: </strong>This pilot study suggests a potential role for cognitive-behavioral therapy supported by a mechanical masturbation device in managing PE, but further research is needed to confirm its effectiveness and comparative advantages.</p><p><strong>Strengths and limitations: </strong>The main strengths of the study is its crossover design, which minimizes the influence of individual patient variability. Limitations include the small sample size, the lack of long-term follow-up to assess the durability of treatment effects, and the absence of a sham arm using masturbation alone, which makes it unclear whether the observed improvements are due to the device itself or the act of masturbating.</p><p><strong>Conclusion: </strong>This pilot study suggests that the cognitive-behavioral therapy program supported by the male masturbation device may offer potential benefits for managing PE, but further research with larger samples is needed to confirm these preliminary findings.<","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association between surgeon procedure volume and reoperation rates for penile prosthesis implantation.","authors":"","doi":"10.1093/jsxmed/qdaf128","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf128","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive behavioural therapy for sexual concerns during menopause: evaluation of a four session protocol.","authors":"Sheryl M Green, Melissa Furtado, Alison K Shea, Elena C Ballantyne, David L Streiner, Benicio N Frey, Randi E McCabe","doi":"10.1093/jsxmed/qdaf085","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf085","url":null,"abstract":"<p><strong>Background: </strong>Sexual concerns are reported by 43%-82.5% of peri- and post-menopausal women and negatively impact physical and emotional well-being. Despite the high prevalence and negative impact, treatment options are limited, particularly those which are non-pharmacological.</p><p><strong>Aim: </strong>The primary objective of this pilot trial was to evaluate the effectiveness of a novel four-session individual Cognitive Behavioural Therapy protocol for improving sexual functioning (CBT-SC-Meno) during peri- and post-menopause. Secondary objectives included assessing body image, relationship satisfaction, and common menopause symptoms (eg, vasomotor), depression, anxiety, and self-reported health.</p><p><strong>Methods: </strong>Participants (n = 32) were peri- or post-menopausal women experiencing primary sexual concerns and reporting a score of 26.55 or lower on the Female Sexual Function Index (FSFI), indicating impaired sexual functioning. Eligible participants were assigned to a waitlist control condition for 4 weeks, after which they were reassessed and then completed the CBT protocol.</p><p><strong>Outcomes: </strong>Measures assessing sexual functioning, satisfaction, distress, and desire, as well as body image, relationship satisfaction, common menopause symptoms (eg, vasomotor), depression, anxiety, and self-reported health were completed at baseline, post-waitlist, and post-treatment. Treatment satisfaction was captured with the Client Satisfaction Questionnaire along with qualitative data.</p><p><strong>Results: </strong>During the waitlist period, no significant changes were observed across measures, apart from the FSDQ concern subscale and GCS physical subscale. Following CBT-SC-Meno, participants experienced a significant improvement in overall sexual functioning (eg, desire, arousal, reduced pain, satisfaction), a decrease in symptoms of sexual distress, concern, and resistance, menopausal symptoms, symptoms of depression and anxiety, as well as improved body image, couple satisfaction, and overall health (P < 0.001). All participants endorsed high treatment satisfaction and indicated that treatment helped them better cope with their symptoms more effectively.</p><p><strong>Clinical implications: </strong>To our knowledge, this is the first study examining the effectiveness of a CBT protocol specifically designed to target sexual concerns experienced during peri- and post-menopause. Results suggest that CBT-SC-Meno leads to significant improvements in sexual functioning across several important sexual concern domains and related areas (eg, body image), in addition to several other commonly comorbid menopausal symptoms (eg, vasomotor), depression, anxiety, and self-reported overall health.</p><p><strong>Strengths and limitations: </strong>Although CBT-SC-Meno appears to be a promising treatment for sexual concerns, the sample was small and homogeneous.</p><p><strong>Conclusions: </strong>This study provides prel","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Inflammatory Burden Index with erectile dysfunction in United States adult men: evidence from NHANES 2001-2004.","authors":"Shengyi Chen, Yuekun Fang, Chenxiao Huang, Bin Cheng","doi":"10.1093/jsxmed/qdaf118","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf118","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, selective serotonin reuptake inhibitors, and sexual wellbeing in assigned females: exploring the moderating role of sexual flexibility.","authors":"Finnoula I O'Neill-King, Robyn A Jackowich, Caroline F Pukall","doi":"10.1093/jsxmed/qdaf097","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf097","url":null,"abstract":"<p><strong>Background: </strong>Depression often causes sexual dysfunction, including reduced desire and pleasure, and selective serotonin reuptake inhibitors (SSRIs), commonly used to treat depression, can worsen these issues, leading to treatment discontinuation.</p><p><strong>Aim: </strong>To examine sexual wellbeing differences across depression and SSRI groups, how depression, SSRI use, and sexual flexibility predict sexual outcomes, and whether sexual flexibility moderates the relationship between sexual functioning, distress, and pleasure.</p><p><strong>Methods: </strong>Participants (N = 357, mean age 26.8 years) assigned female sex at birth were recruited for an online cross-sectional study. Participants were grouped by SSRI use and depression severity: SSRIs-low depression (n = 86), SSRIs-high depression (n = 117), no SSRIs-low depression (n = 81), and no SSRIs-high depression (n = 73).</p><p><strong>Outcomes: </strong>Validated measures of depression, sexual function, sexual distress, sexual flexibility, and sexual pleasure were used.</p><p><strong>Results: </strong>Analyses of variance (ANOVAs) and multiple regressions examined relationships between depression, SSRI use, and sexual wellbeing. Moderation analyses tested whether sexual flexibility moderated the link between sexual functioning, distress, and pleasure. The SSRIs-high depression group reported the poorest sexual wellbeing, while the No SSRIs-low depression group reported the highest. Depression and SSRI use predicted increased sexual distress and decreased functioning, pleasure, and flexibility, explaining 21%-26% of variance. Sexual flexibility moderated the relationship between functioning and pleasure, with stronger effects at lower flexibility levels.</p><p><strong>Clinical implications: </strong>Sexual flexibility may improve sexual functioning and pleasure, providing a positive, adaptable framework for therapy; thus, psychosexual and educational interventions focusing on flexibility could enhance sexual pleasure and reduce distress, fostering sexual resilience and improving relationship dynamics.</p><p><strong>Strengths and limitations: </strong>Strengths include a nuanced analysis of depression severity and SSRI use, offering a comprehensive view of sexual wellbeing. Limitations include reliance on self-reported medication use, inability to assess specific SSRIs, and potential confounding from concurrent antidepressant use.</p><p><strong>Conclusion: </strong>SSRIs and depression each uniquely affect sexual functioning, distress, and pleasure, such that those with moderate to severe depression and SSRI use report significantly poorer sexual outcomes.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological findings in the genital organs of assigned female at birth transgender people undergoing genital gender-affirming surgery.","authors":"Chiara Ferraguti, Alessandra Lami, Laura Cocchi, Veronica Amati, Renato Seracchioli, Maria Cristina Meriggiola","doi":"10.1093/jsxmed/qdaf087","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf087","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lower urinary tract symptoms and female sexual function: results from the GENitourinary syndrome of menopause in JApanese women (GENJA) study.","authors":"Yumi Ozaki, Hikaru Tomoe, Mayuka Shimomura, Noriko Ninomiya, Yuki Sekiguchi, Yoshikazu Sato, Yoshimitsu Takahashi, Satoru Takahashi","doi":"10.1093/jsxmed/qdaf080","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf080","url":null,"abstract":"<p><strong>Background: </strong>Female sexual dysfunction (FSD) is highly prevalent in women with lower urinary tract symptoms (LUTS); however, few studies have assessed the association between specific LUTS and FSD.</p><p><strong>Aim: </strong>To identify which specific LUTS are associated with which domains of female sexual function in Japanese women.</p><p><strong>Methods: </strong>Data from 1337 sexually active women aged 40-79 years who participated in the GENitourinary syndrome of menopause in JApanese women (GENJA) study were analyzed. All participants answered web-based questionnaires including the Core Lower Urinary Tract Symptom Score, Female Sexual Function Index (FSFI), and Vulvovaginal Symptoms Questionnaire. We used multivariable regression to assess the association between LUTS and FSFI domain scores, adjusted for age, menstrual status, hormone therapy, hypertension, dyslipidemia, diabetes mellitus, and depression.</p><p><strong>Outcomes: </strong>FSFI domain and total scores associated with LUTS.</p><p><strong>Results: </strong>The mean age of participants was 54.0 ± 10.7 years. Women with LUTS were more likely to have lower total FSFI scores than those without, except for increased daytime urinary frequency. The multivariate analysis revealed that nocturia was associated with lower orgasm scores (coefficient: -0.23; 95% confidence interval [CI]: -0.45 to -0.01; P = .044), urgency with lower pain scores (coefficient: -0.62; CI: -1.09 to -0.14; P = .011), stress urinary incontinence (coefficient: -0.51; CI: -0.90 to -0.12; P = .011), and vaginal bulge/lump sensations (coefficient: -0.42; CI: -0.81 to -0.04; P = .031) with lower satisfaction scores.</p><p><strong>Clinical implications: </strong>This study highlights the need to include routine assessments of sexual function in women with LUTS.</p><p><strong>Strengths and limitations: </strong>This is the first study to comprehensively examine the association between specific LUTS and FSFI domain scores using validated questionnaires in a nationwide epidemiological survey among sexually active Japanese women. Limitations include non-random participant selection and reliance on self-reported data, which represent subjective symptoms.</p><p><strong>Conclusion: </strong>LUTS, including nocturia, urgency, stress urinary incontinence, as well as vaginal bulge/lump sensations, were associated with FSD regardless of age, menstrual status, lifestyle-related diseases, or depression.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Enzian and rASRM classifications in predicting symptoms of sexual dysfunction in endometriosis.","authors":"Paula Norinho, Rosa Zulmira Vaz de Macedo, Mariana M Martins, Hélder Ferreira","doi":"10.1093/jsxmed/qdaf086","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf086","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Endometriosis is known to negatively impact sexual function; however, limited research has explored whether classification systems can help pinpoint specific anatomical locations associated with sexual dysfunction. This study was necessitated by the paucity of literature on classification systems that allow clinicians to associate specific symptoms of sexual dysfunction with particular locations of deep infiltrating endometriosis (DIE).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aimed to investigate whether the Enzian and revised American Society for Reproductive Medicine (rASRM) classification systems can predict sexual dysfunction based on the localization and extent of DIE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A clinical study was conducted with 77 women with histologically confirmed DIE. Data were collected from gynecological consultations and surgical reports classified using the rASRM and Enzian systems. Sexual function was assessed using the Female Sexual Function Index. Statistical analyses included Fisher's exact test, Mann-Whitney test, and Student's t-test.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The primary outcome was to examine the relationship between endometriosis localization, disease extent, and sexual dysfunction as indicated by the two classification systems under investigation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A possible association was identified between sexual dysfunction and Enzian B classification (p = 0.013*), implicating involvement of the sacrouterine ligaments, cardinal ligaments, or pelvic sidewall. No significant association was found between sexual dysfunction and rASRM scores. A correlation between the number of endometriosis locations and the presence of sexual dysfunction was also observed (p = 0.015*). However, it is important to note that patients classified as Enzian B may have had additional, undocumented lesions in other locations not identified through available medical records, imaging, or surgical reports. These unidentified lesions could have influenced their sexual dysfunction, representing a potential confounding factor in our analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;These findings suggest that the localization of DIE may contribute to sexual dysfunction, but further validation is required before drawing clinical conclusions regarding surgical interventions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths & limitations: &lt;/strong&gt;This is the first study to explore the ability of a classification system to pinpoint sexual dysfunction in endometriosis to a particular anatomical location, providing novel insights into DIE's impact on sexual health. However, variability in referral sources, the potential for undocumented lesions, and a small sample size for cases of sexual dysfunction may limit the generalizability of these findings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Disease localization, particularly in the uterosacral ligaments and pelvic sidewall, may contribute to sexual dysfunction, offering po","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}