Journal of Sexual Medicine最新文献

{"title":"Assessing vulvar dermatology education in medical school preclinical and clinical curriculum.","authors":"Kennedy H Sun, Rachel Bernardo, Scarlett J Bergam, Yagiz Matthew Akiska, Allison Etcheverry, Emily Murphy","doi":"10.1093/jsxmed/qdaf257","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf257","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adding vaginal dilators to manual therapy in women with genito-pelvic pain/penetration disorder: a randomized controlled trial.","authors":"Lyana Belém Marinho, Letícia Rodrigues Silva, Alana Leandro Cabral, Rogério de Melo Costa Pinto, Ana Paula Magalhães Resende, Vanessa Santos Pereira Baldon","doi":"10.1093/jsxmed/qdaf259","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf259","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural changes in lifelong premature ejaculation patients: insights from multivariate and neurotransmitter analyses.","authors":"Jiarui Yuan, Pinxiao Wang, Jianyong Feng, Yiwei Liu, Zhuoxi Zhang, Yanzhu Wang, Ming Gao, Junjun Gao","doi":"10.1093/jsxmed/qdaf262","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf262","url":null,"abstract":"<p><strong>Background: </strong>Lifelong premature ejaculation (PE) is one of the most commonly reported male sexual dysfunctions, previous studies of lifelong PE-related brain structures used univariate analysis and showed inconsistent results.</p><p><strong>Aim: </strong>To explore the structural abnormalities and the potential neurotransmitter profile alterations in lifelong PE patients.</p><p><strong>Methods: </strong>Based on T1-weighted anatomical data derived from 47 lifelong PE patients and 34 healthy controls (HCs), gray matter volume (GMV) maps were decomposed into independent components (ICs) by source-based morphometry technique to investigate the abnormal brain structure between groups. Shapley Additive exPlanations (SHAP) analysis was applied to assess the importance of the identified imaging features. Then, spatial association analyses were applied to explore possible relationships between GMV abnormalities and neurotransmitter profiles.</p><p><strong>Outcomes: </strong>Study outcomes included GMV by two sample t test between groups, spatial correlation between identified components and neurotransmitter profiles, and the importance of the identified imaging features in SHAP analysis.</p><p><strong>Results: </strong>GMV abnormalities were mainly located in the default mode network, prefrontal cortex and temporal lobe in lifelong PE. The SHAP analysis revealed that GMV components of IC22, IC25, and IC1 constitute the most critical features for classification prediction. Moreover, GMV abnormalities were correlated with the serotoninergic, dopaminergic, gamma-aminobutric acid, glutamatergic, and noradrenergic systems.</p><p><strong>Clinical implications: </strong>These findings help to better understanding the underlying pathological mechanisms of lifelong PE and provide a basis for formulating targeted treatment strategies in the future.</p><p><strong>Strengths & limitations: </strong>This study demonstrated the structure-neurotransmitter associations of lifelong PE by combining multivariate analysis with neurotransmitter profiles. Moreover, SHAP interpretability analysis was used to ensure model accountability in machine learning. The sample size of our study was relatively small. To enhance generalizability, larger-scale cohorts and independent validation datasets will be collected in the future.</p><p><strong>Conclusions: </strong>These findings provided further evidence of GMV abnormalities in lifelong PE relevant to self-referential information processing and ejaculatory inhibition controlling.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Penile Implant Risk Score-6 (PIRS-6): a preliminary retrospective study for risk stratification of surgical site infections in malleable prosthesis recipients.","authors":"Adham AbdelKader, Mohammed A Abdel-Rassoul, Galal El Shorbagy, Nadia Mohammed Hassan Madany, Hesham Torad","doi":"10.1093/jsxmed/qdaf260","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf260","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we talk about sex? Feasibility of universal sexual health screening for BRCA1/2 patients.","authors":"Amita Kulkarni, Luiza Perez, Lauren Mitchell, Muhammad Danyal Ahsan, Jesse Brewer, Charlene Thomas, Eloise Chapman-Davis, Evelyn Cantillo, Kevin Holcomb, Shoshana Rosenberg, Melissa K Frey","doi":"10.1093/jsxmed/qdaf256","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf256","url":null,"abstract":"<p><strong>Background: </strong>Risk-reducing salpingo-oophorectomy for ovarian cancer risk reduction in individuals with BRCA1/2 pathogenic variants can cause sexual dysfunction, yet sexual health discussions between patients and providers remain limited.</p><p><strong>Aim: </strong>We describe the feasibility of universal sexual health screening and rates of sexual health dysfunction among individuals with BRCA1/2 pathogenic variants.</p><p><strong>Methods: </strong>Patients with BRCA1/2 pathogenic variants presenting to an outpatient gynecologic oncology clinic from January 2022 to February 2023 were offered a sexual health screener. The screener combined a validated, single-item sexual dysfunction assessment with three additional questions exploring discussions of sexual health with healthcare providers, desire for information about sexual health, and preferred methods for delivery of information.</p><p><strong>Outcomes: </strong>The primary outcome was the proportion of patients who completed the sexual health screener and the secondary outcomes included rate of sexual dysfunction and impact of patient characteristics on sexual dysfunction.</p><p><strong>Results: </strong>Among 103 patients offered the sexual health screening, 100% completed it. Median age was 42 years (range 25-84). Eighty three (81%) patients self-identified as White, 32 (31%) patients had a history of cancer, 42 (41%) had undergone risk-reducing salpingo-oophorectomy, and 47 (46%) were pre-menopausal. Thirty seven (36%) patients screened positive for sexual dysfunction. Among patients with premature menopause following salpingo-oophorectomy, 6/15 (40%) on hormone replacement therapy reported sexual dysfunction versus 6/10 (60%) not on hormone replacement therapy (P = .43). Across all patients, 38 (37%) had never previously discussed sexual health concerns with a provider. There were no significant differences in sexual dysfunction rates based on any measured patient characteristics.</p><p><strong>Clinical implications: </strong>Universal sexual health screening for individuals with BRCA1/2 pathogenic variants is feasible and may provide an avenue for more in-depth discussion with at-risk patients, who may not have previously discussed this issue with their medical team.</p><p><strong>Strengths and limitations: </strong>Our study found that it was feasible to administer a sexual health screening tool among an at-risk patient population in a clinical setting. Generalizability may be limited due to the composition of our cohort, which was small, majority White and non-Hispanic, and from a single institution.</p><p><strong>Conclusion: </strong>Providers should consider implementing standardized sexual health screening practices among patients with BRCA1/2 pathogenic variants.</p><p><strong>Research highlights: </strong></p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapoxetine combined with non-pharmacological approaches for lifelong premature ejaculation. A systematic review and meta-analysis.","authors":"Marta Nieves Martín, Patricia Marín Novoa, Juan Avendaño-Coy","doi":"10.1093/jsxmed/qdaf238","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf238","url":null,"abstract":"<p><strong>Introduction: </strong>Recent research has highlighted the potential advantages of combining pharmacologic and non-pharmacologic approaches in treating lifelong premature ejaculation (LPE). Individual therapies have demonstrated efficacy but there is a lack of comprehensive analysis comparing combined treatments to pharmacologic monotherapy.</p><p><strong>Objectives: </strong>To assess the combined effect of dapoxetine with non-pharmacological therapies compared to drug monotherapy in improving ejaculatory latency, functionality, and self-perception of sexual dysfunction in individuals with LPE.</p><p><strong>Methods: </strong>A systematic search was performed in PubMed, PEDro, Cochrane, Web of Science, CINAHL, and Academic Search Ultimate databases from inception to October 2024 to identify randomized controlled trials (RCTs). The primary outcome was the intravaginal ejaculatory latency time (IELT), while secondary outcomes were self-perception improvements, assessed using the Premature Ejaculation Diagnostic Tool (PEDT), the premature ejaculation profile (PEP), and other evaluation instruments.</p><p><strong>Results: </strong>Eight RCTs (n = 656 participants) were included. Pooled analysis of studies showed a significant effect of dapoxetine combined with non-pharmacological therapies in improving IELT compared to dapoxetine monotherapy (SDM = 1.6; 95%CI, 0.5-2.8; P = .01), PEDT scores (SDM = 0.9; 95%CI, 0.4-1.4; P < .001) and PEP subscales, with moderate certainty of evidence according to the GRADE guidelines. The non-pharmacological therapies included shockwave therapy, biofeedback, electric stimulation, pelvic floor muscle training, desensitization techniques, psychotherapy, and behavioral therapy.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis indicate that while dapoxetine is recognized for its beneficial effects, its clinical efficacy is significantly enhanced when combined with non-pharmacological interventions. Combination therapy increases IELT, reduces PEDT scores, and improves PEP scores. These findings suggest that combination therapy is more effective than dapoxetine monotherapy in improving functional outcomes and self-perception in patients with LPE, supported by moderate certainty of evidence.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barry shunt in prolonged ischemic priapism: a novel treatment algorithm.","authors":"Türker Soydaş, Onur Enes Tunç, Halil Uzundal, Selman Ünal, Fatih Akdemir, Emrah Okulu, Önder Kayıgil","doi":"10.1093/jsxmed/qdaf240","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf240","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotypical love: a cluster analysis of self-presentation strategies in tinder profile pictures.","authors":"Alejandro García-Alamán, Sergi Blanco-Cuaresma, Adrián Montesano","doi":"10.1093/jsxmed/qdaf245","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf245","url":null,"abstract":"<p><strong>Background: </strong>Although dating apps are the preferred means of meeting sexual and romantic partners, users frequently experience disappointment, highlighting the importance of understanding self-presentation strategies and selection processes to mitigate negative experiences.</p><p><strong>Aim: </strong>This study examines self-presentation strategies in Tinder profile pictures, aiming to identify typological patterns, characterize common profile-building strategies, and analyze differences by age, gender, and sexual orientation.</p><p><strong>Methods: </strong>We employed a mixed dimensional approach-both categorical and numerical-to characterize and categorize 1000 Tinder profile pictures. A descriptive category set was developed to analyze key picture elements, and a not-safe-for-work nudity index was computed using an open-source neural network. We then applied K-means clustering to identify patterns in the data.</p><p><strong>Outcomes: </strong>The main outcome measures included the clustering distribution of profile picture types and their associations with demographic variables (Standardized Pearson Residuals).</p><p><strong>Results: </strong>Our analysis identified nine prototypical Tinder profile image categories, confirming the presence of stereotypical patterns in self-presentation. Additionally, we found statistically significant associations between profile clustering and user demographics, particularly age, gender, and sexual orientation.</p><p><strong>Clinical implications: </strong>Stereotyped self-disclosure in dating apps may hinder partner selection by reinforcing social biases related to age, gender, and sexual orientation, with potential consequences for sexual and couple therapy.</p><p><strong>Strengths & limitations: </strong>Key strengths include the use of a large and diverse dataset, robust cluster validation techniques, and a novel approach to analyzing self-presentation on dating apps. Limitations, however, include potential biases due to the categorical nature of the data, difficulties in capturing individual nuances in self-presentation, and the inability to account for Tinder algorithm influences on image use.</p><p><strong>Conclusion: </strong>Clustering techniques provide an empirical framework for identifying stereotypical self-presentation patterns and demographic differences, which could be extended to analyzing written descriptions and partner selection mechanisms.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of penile glans necrosis.","authors":"Hygor Franca Buss, Fabio Thadeu Ferreira, Thiago Guedes Giles, Thiely Guedes Giles","doi":"10.1093/jsxmed/qdaf251","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf251","url":null,"abstract":"<p><strong>Introduction: </strong>Penile glans necrosis is a rare, debilitating condition with significant cosmetic and functional consequences. Despite its clinical importance, no standardized treatment protocol exists owing to a lack of robust evidence and variability in management practices.</p><p><strong>Objectives: </strong>This systematic review aims to evaluate therapeutic interventions for penile glans ischemia and necrosis, identify gaps in current knowledge, and propose a framework for future clinical practice.</p><p><strong>Methods: </strong>In accordance with the PRISMA 2020 statement, a systematic search of PubMed was performed from March 2024 to May 2025 using predefined search terms related to penile glans ischemia and necrosis. The inclusion criteria focused on cases of ischemia caused by reduced blood flow, excluding those linked to infections, calciphylaxis, priapism, or immediate surgical interventions. Outcomes were classified by lesion extent and type (grades I-III, A-B), and statistical analyses explored associations between treatment modalities and outcomes. Risk of bias was assessed with the JBI and Risk Of Bias In Non-randomized Studies-of Interventions tools.</p><p><strong>Results: </strong>Data from 48 studies encompassing 79 patients were analyzed. Circumcision (n = 55) and prostatic artery embolization (n = 13) were the most common etiologies. Treatments varied widely, including hyperbaric oxygen therapy (44.94%), antibiotics (43.82%), surgical interventions (43.82%), and pentoxifylline (40.45%). While grade A ischemia was significantly associated with better outcomes (P < .001, odds ratio = 182.77), no single treatment modality demonstrated statistically superior efficacy when compared pairwise. Antibiotic therapy and surgical interventions were associated with worse outcomes, likely reflecting their use in more severe cases. Publication bias and heterogeneity in case descriptions posed challenges to definitive conclusions.</p><p><strong>Conclusion: </strong>Early recognition of ischemia significantly improves outcomes, highlighting the importance of prompt diagnosis and intervention, and the combination of pentoxifylline, hyperbaric oxygen therapy, anticoagulation, and topical agents may offer synergistic benefits. The findings of this review underscore the critical need for evidence-based protocols, standardized classification systems, consistent therapeutic strategies, and robust clinical trials; future research should focus on prospective studies with standardized methodologies to optimize care and improve functional and aesthetic outcomes for affected patients.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive repetitive transcranial magnetic stimulation for compulsive sexual behavior in a young adult with bipolar I disorder: a case report.","authors":"Atila Abulizi, Zubeila Aihemaiti, Reziya Dilixiati, Diliyaer Dilixiati, Li Xu","doi":"10.1093/jsxmed/qdaf258","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf258","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}