{"title":"The association between depression and anxiety with female sexual function in young women with polycystic ovary syndrome.","authors":"Meral Cevik Dogan, Tevfik Yoldemir","doi":"10.1093/jsxmed/qdaf050","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf050","url":null,"abstract":"<p><strong>Background: </strong>PCOS and its associated symptoms might be related to anxiety and depressive symptoms which may influence sexual function.</p><p><strong>Aim: </strong>To investigate the association between depression and anxiety with female sexual function among women with polycystic ovary syndrome (PCOS) during reproductive age.</p><p><strong>Methods: </strong>The study group included 268 women with PCOS and 158 women without PCOS between the ages of 18 and 35 years. Serum testosterone, androstenedione, dehydroepiandrostenedione sulfate (DHEA-S), fasting glucose, sex-hormone binding globulin, and fasting insulin levels were analyzed. The McCoy Female Sexual Questionnaire (MFSQ), and Beck Anxiety and Depression Inventories (BAI and BDI) were distributed to women with PCOS and controls.</p><p><strong>Outcomes: </strong>MFSQ, BDI, and BAI scores were compared between women with PCOS and controls.</p><p><strong>Results: </strong>There was a significant difference between the PCOS and non-PCOS groups when BDI (18.92 ± 11.09 vs 10.20 ± 8.66, p = 0.001) and BAI (12.45 ± 9.67 vs 8.08 ± 8.90, p = 0.001) subgroups were compared. A weak negative correlation was present between McCoy's sexuality domain (r = -0.304), McCoy's Sexual partner domain (r = -0.215), and BAI score among PCOS women. A moderate negative correlation between McCoy's sexuality domain (r = -0.515), and a weak correlation between McCoy's Sexual partner domain (r = -0.271) and BDI score among PCOS women were found.</p><p><strong>Clinical implications: </strong>Women with PCOS report more severe depression, anxiety, and sexual dysfunction than non-PCOS women.</p><p><strong>Strengths & limitations: </strong>Socio-cultural identity, awareness, perceptions of body image, and interpersonal relations were not investigated in the current study. These play a role in the interactions between sexual dysfunction and mood disorder. The strength of our study was that the prevalence of PCOS features was different between the various depression and anxiety subgroups.</p><p><strong>Conclusion: </strong>The women with PCOS were more likely to have moderate-severe anxiety and moderate-severe depression while their mean total scores of the two domains of MFSQ were lower when compared to non-PCOS women.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of overactive bladder on sexual health in women with diabetes.","authors":"Cansu Polat Dunya, Arzu Erkoc, Medine Yucesoy, Mehmet Gokhan Culha, Mine Adas","doi":"10.1093/jsxmed/qdaf052","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf052","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of overactive bladder symptoms and sexual dysfunction is increased in women with type 2 diabetes, and this can negatively impact their quality of life.</p><p><strong>Aim: </strong>To evaluate the effects of overactive bladder on sexual function and the quality of sexual life in women with and without type 2 diabetes.</p><p><strong>Methods: </strong>This cross-sectional study included 168 women who were assigned to 4 groups: healthy women (n = 42), women with overactive bladder (n = 42), women with diabetes but without overactive bladder (n = 42), and women with both diabetes and overactive bladder (n = 42). Data were collected using the Overactive Bladder 8-Question Awareness Tool, the Female Sexual Function Index, and the Sexual Quality of Life-Female questionnaire. The variables assessed with these tools were analyzed using the Kruskal-Wallis test.</p><p><strong>Outcomes: </strong>The levels of overactive bladder symptoms, sexual function, and sexual quality of life in women were evaluated.</p><p><strong>Results: </strong>The overactive bladder and sexual function scores of women with overactive bladder and women with both diabetes and overactive bladder were significantly worse compared to those of healthy women (P ˂ .001). In particular, women with both diabetes and overactive bladder had lower levels of sexual quality of life compared to women with overactive bladder and healthy women (P ˂ .001).</p><p><strong>Clinical implications: </strong>The study reveals that overactive bladder symptoms and diabetes severely affect women's quality of sexual life, emphasizing that these problems should be a routine part of clinical assessment.</p><p><strong>Strengths and limitations: </strong>The strength of the study lies in its unique approach as the first to comprehensively examine the effect of diabetes and overactive bladder on sexuality through a comparison of 4 distinct groups of women. Collecting data using valid and reliable scales and applying the STROBE checklist increases methodological rigor. However, the limited sample size restricts generalizability, and causal relationships cannot be established due to the cross-sectional design. In addition, self-reported data may increase the risk of bias.</p><p><strong>Conclusion: </strong>This study highlights that diabetes and overactive bladder symptoms negatively affect women's sexual function and sexual quality of life and that comprehensive and individualized treatment plans should be developed.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decompression, subcoronal internal shunting and tunneling: a novel approach for ischemic priapism.","authors":"Andrew Y Sun, Paurush Babbar","doi":"10.1093/jsxmed/qdaf062","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf062","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obesity and sexual desire: a systematic review and meta-analysis.","authors":"Małgorzata Biernikiewicz, Agnieszka Rusiecka, Dariusz Kałka","doi":"10.1093/jsxmed/qdaf057","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf057","url":null,"abstract":"<p><strong>Background: </strong>Impaired sexual functioning is one of the consequences of obesity with hormonal disorders involving testosterone.</p><p><strong>Aim: </strong>To explore the link between obesity and sexual desire, to assess how changes in body weight affect sexual desire, and to examine the role of testosterone in these changes in obese and overweight men.</p><p><strong>Methods: </strong>The systematic review was conducted in PubMed. Studies involving obese/overweight men that reported different libido levels or changes after weight loss interventions were included. Meta-analysis and meta-regression were performed.</p><p><strong>Results: </strong>The search identified 2259 studies, of which 28 met the eligibility criteria. Most studies focused on weight-loss interventions (n = 21, 77%), with 13 studies investigating the effect of bariatric surgeries. Testosterone levels were reported in 14 studies. The studies encompassed a total population of 18 653 people, including 10 356 obese and overweight men. Of the 28 identified studies, 15 indicated a potential association between BMI, waist circumference, and sexual desire. Effect size meta-analysis (calculated using data from four studies presenting results before and after bariatric surgery) suggests that an increase in the International Index of Erectile Function sexual desire domain was very strongly associated with changes in a patients' weight resulting from bariatric surgery (d = 1.22, 95% CI 0.41-2.03, P = 0.003). The meta-analysis of four studies, presenting results before and after diet intervention, showed a strong impact of weight loss on an increase of the Sexual Desire Inventory (SDI), (d = 1.16, 95% CI 0.44-1.88, P = 0.002) The meta-regression revealed a significant association between the level of sexual desire on the SDI and the magnitude of BMI changes before and after dieting interventions (R2 = 77.97%; P = 0.002). The meta-analysis of plasma total testosterone levels from studies that present results before and after selected diets showed a strong impact of diet on the increase in testosterone levels after interventions (d = 1.39 95% CI 0.86-1.92; P < 0.001). There was a significant impact of the level of plasma total testosterone on the variance of sexual desire in the SDI questionnaire (R2 = 5.33%; P < 0.001).</p><p><strong>Limitations of evidence: </strong>A lack of studies that focus on sexual desire in obesity, the heterogeneity of the included population, the variability in the used questionnaires and reported statistics.</p><p><strong>Conclusions: </strong>A potential association between sexual desire and body weight exists. Weight loss interventions, including dietary changes and bariatric surgery, significantly increased both sexual desire and plasma total testosterone levels. Additionally, variations in plasma total testosterone levels had a significant effect on the variability of sexual desire in obese men.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor on \"The importance of gender medicine in understanding sexual dysfunction in female patients with multiple sclerosis\".","authors":"Rocco Salvatore Calabrò","doi":"10.1093/jsxmed/qdaf065","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf065","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: The relationship between sexual health literacy and sexual function of women with diabetes mellitus: a cross-sectional study.","authors":"","doi":"10.1093/jsxmed/qdaf069","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf069","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Davis, Jacob Hershenhouse, Marissa Maas, Jeffrey Loh-Doyle, Kian Asanad
{"title":"Association of cannabis abuse/dependence on risks of erectile dysfunction and testosterone deficiency using a large claims database analysis.","authors":"Ryan Davis, Jacob Hershenhouse, Marissa Maas, Jeffrey Loh-Doyle, Kian Asanad","doi":"10.1093/jsxmed/qdaf043","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf043","url":null,"abstract":"<p><strong>Background: </strong>Cannabis is widely consumed across the United States; however, studies assessing the association between cannabis use and male sexual health, specifically erectile dysfunction (ED) and testosterone deficiency (TD), have mixed results and small sample sizes.</p><p><strong>Aim: </strong>To evaluate the impact of cannabis abuse/dependence on risks of ED, phosphodiesterase-5 inhibitor (PDE5-i) prescription, TD, and testosterone replacement therapy (TRT) using a population-level analysis.</p><p><strong>Methods: </strong>We sampled men ≥18 years old from the large claims database, TriNetX, in 2025. Patients previously diagnosed with or treated for ED or TD and those with prior prostatectomy were excluded. Patients were split into two cohorts: diagnoses of cannabis abuse/dependence or not. Cohorts were propensity score-matched on 49 pertinent factors. Risk of ED, TD, PDE5-i prescription, and TRT were compared at 3 months-1 year (patients from 2005-2024) and 3-5 years (patients from 2005-2020) from cannabis diagnoses. Subgroups of age younger or older than 40 years were also analyzed. Kaplan-Meier survival analysis was performed to assess differences in time to development of ED and TD.</p><p><strong>Outcomes: </strong>Primary outcomes were risk of diagnosis of ED or TD (testosterone level <300 ng/dL). Secondary outcomes were risk of new prescription of PDE5-i or TRT.</p><p><strong>Results: </strong>Between 2005-2024, 30 964 patients with and 1 473 182 without cannabis diagnoses were identified with 29 442 in each cohort after matching. Between 2005-2020, 17 948 patients with and 839 496 without cannabis abuse/dependence were identified, with 17 211 in each cohort after matching. Cannabis abuse/dependence was significantly associated with ED (0.9% vs. 0.2%, RR = 3.99 [3.05, 5.21]), TD (0.2% vs. 0.1%, RR = 2.19 [1.45, 3.31]), and PDE5-i prescription (0.8% vs. 0.2%, RR = 3.80 [2.86, 5.04]) at 3 months-1 year, and only ED at 3-5 years (1.61% vs. 1.34%, RR = 1.20, 95% CI = [1.01, 1.43]). Kaplan-Meier analysis revealed significantly shorter time to development of ED (HR = 1.65, 95% CI = [1.47, 1.85]) and TD (HR = 1.34, 95% CI = 1.07, 1.69]) associated with cannabis abuse/dependence. No association between cannabis abuse/dependence and TRT was found. In those <40 years old, only ED and PDE5-i were significant at 3 months-1 year, but not at 3-5 years.</p><p><strong>Clinical implications: </strong>Our findings support an association between cannabis abuse/dependence, ED, and TD, which providers may consider when treating patients with these diagnoses.</p><p><strong>Strengths and limitations: </strong>Strengths include having a large, national sample of patients. Limitations include inability to assess dose-dependent relationships and using diagnosis codes as proxies for cannabis use.</p><p><strong>Conclusion: </strong>Cannabis abuse/dependence is associated with increased risk of ED, PDE5-i prescription, and TD.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Online expressive writing intervention for the psychosexual well-being of women with a history of childhood sexual abuse: a randomized clinical trial.","authors":"Chelsea D Kilimnik, Cindy M Meston","doi":"10.1093/jsxmed/qdaf035","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf035","url":null,"abstract":"<p><strong>Background: </strong>Sexual schema expressive writing that addresses nonconsensual sexual experiences has demonstrated initial support for improving psychosexual well-being for women with childhood sexual abuse (CSA) histories and is easily modifiable to an online modality for accessibility and scalability.</p><p><strong>Aim: </strong>The current study aimed to assess the online efficacy of a 5-session sexual schema expressive writing intervention against a daily events writing condition and an assessment-only condition for women with CSA histories.</p><p><strong>Methods: </strong>Women were initially randomized to 1 of the 2 active writing conditions (sexual schema, n = 73; daily events, n = 71); then, to minimize awareness of anticipated results, an assessment-only condition was recruited (n = 22). Outcomes were measured at baseline (T1), 3 weeks after baseline/posttreatment (T2), and at 1-month follow-up (T3). Additionally, participant-perceived change in sexual and psychological functioning across the course of the study was assessed at T2 and T3.</p><p><strong>Outcomes: </strong>Outcomes included posttraumatic stress symptoms, sexual functioning, global self-esteem, and sexual self-concept.</p><p><strong>Results: </strong>Mixed effects linear regression models controlling for participant age demonstrated significantly greater rates of change in sexual functioning and sexual self-concept for both active writing conditions (sexual schema and daily events) in comparison with the assessment-only condition, with no differences across conditions in posttraumatic stress symptoms or self-esteem. Furthermore, analyses of variance controlling for age indicated that women in the sexual schema writing condition reported significantly greater perceived change in sexual well-being and psychological well-being than the assessment-only condition, though the daily events writing condition reported significantly greater perceived change only in psychological well-being as compared with the assessment-only condition.</p><p><strong>Clinical implications: </strong>The current study provides evidence for the use of online modalities for expressive writing for women with CSA histories and supports the use of sexual schema writing paradigms for improving sexual well-being in this population.</p><p><strong>Strengths and limitations: </strong>The study is strengthened by its ecologically valid and diverse community sample and its rigorous multisession treatment protocol. The study is limited by being underpowered for some of its analyses. Additional research is needed on the daily events writing condition and ways to target more psychological outcomes in combination with sexual outcomes in online writing treatments.</p><p><strong>Conclusions: </strong>Online expressive writing paradigms that allow for guided reflection and space on how individuals' nonconsensual sexual experiences have affected their sexuality may be a fruitful strategy for many women to b","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous perineal urethroplasty and penile prosthesis explantation for urethral stricture and fractured malleable penile prosthesis through a single perineal incision: a case report and literature review.","authors":"Nazim Furkan Gunay, Fatih Yanaral, Omer Sarilar","doi":"10.1093/jsxmed/qdaf049","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf049","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinoni Marta, Cucurachi Giorgia, Porpora Maria Grazia, Grano Caterina
{"title":"Exploring pain perception and depression in vulvodynia: the role of catastrophizing and pain acceptance.","authors":"Spinoni Marta, Cucurachi Giorgia, Porpora Maria Grazia, Grano Caterina","doi":"10.1093/jsxmed/qdaf046","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf046","url":null,"abstract":"<p><strong>Background: </strong>In the context of vulvodynia, a gynecological disorder characterized by chronic vulvar pain affecting an estimated 10% of women, with significant impacts on sexual health, mental well-being, and productivity, the Common-Sense Model of Illness Self-Regulation, a well-established framework for understanding the impact of illness perceptions and coping strategies on mental health, has not yet been empirically tested.</p><p><strong>Aim: </strong>We aimed to explore whether illness perceptions and pain-specific coping strategies-namely, pain catastrophizing and chronic pain acceptance-influence the relationship between vulvar pain severity and depression in women with vulvodynia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on a total of 119 women with reporting diagnosis of vulvodynia.</p><p><strong>Outcomes: </strong>Through an online questionnaire, we assessed demographic and clinical characteristics, vulvar pain severity, illness beliefs, pain catastrophizing, pain acceptance, and depressive symptoms.</p><p><strong>Results: </strong>The path analysis showed that vulvar pain positively influences directly illness perceptions (β = .56, P < .001) and depressive symptoms (β = .24, P < .001). Negative perceptions of the illness were significantly associated with increased pain catastrophizing (β = .66, P < .001), and decreased pain acceptance (β = -.59, P < .001), resulting in heightened depressive symptoms (β = .33, P < .001, β = -.27, P < .001, respectively).</p><p><strong>Clinical implications: </strong>Interventions that challenge negative illness perceptions and promote more positive views could reduce maladaptive coping strategies, enhance pain acceptance, and ultimately diminish psychological distress.</p><p><strong>Strengths and limitations: </strong>This study's strengths lie in its foundation on a theoretical, well-established model and the use of validated measures. However, the cross-sectional design precludes concluding causality between predictor and outcome variables, and the clinical information was self-reported and could not be verified with medical records.</p><p><strong>Conclusions: </strong>The findings underscore the importance of targeting illness perceptions and coping strategies in shaping psychological outcomes for women with vulvodynia.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}