Journal of Sexual Medicine最新文献

{"title":"Correction to: The relationship between sexual health literacy and sexual function of women with diabetes mellitus: a cross-sectional study.","authors":"","doi":"10.1093/jsxmed/qdaf069","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf069","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cannabis abuse/dependence on risks of erectile dysfunction and testosterone deficiency using a large claims database analysis.","authors":"Ryan Davis, Jacob Hershenhouse, Marissa Maas, Jeffrey Loh-Doyle, Kian Asanad","doi":"10.1093/jsxmed/qdaf043","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf043","url":null,"abstract":"<p><strong>Background: </strong>Cannabis is widely consumed across the United States; however, studies assessing the association between cannabis use and male sexual health, specifically erectile dysfunction (ED) and testosterone deficiency (TD), have mixed results and small sample sizes.</p><p><strong>Aim: </strong>To evaluate the impact of cannabis abuse/dependence on risks of ED, phosphodiesterase-5 inhibitor (PDE5-i) prescription, TD, and testosterone replacement therapy (TRT) using a population-level analysis.</p><p><strong>Methods: </strong>We sampled men ≥18 years old from the large claims database, TriNetX, in 2025. Patients previously diagnosed with or treated for ED or TD and those with prior prostatectomy were excluded. Patients were split into two cohorts: diagnoses of cannabis abuse/dependence or not. Cohorts were propensity score-matched on 49 pertinent factors. Risk of ED, TD, PDE5-i prescription, and TRT were compared at 3 months-1 year (patients from 2005-2024) and 3-5 years (patients from 2005-2020) from cannabis diagnoses. Subgroups of age younger or older than 40 years were also analyzed. Kaplan-Meier survival analysis was performed to assess differences in time to development of ED and TD.</p><p><strong>Outcomes: </strong>Primary outcomes were risk of diagnosis of ED or TD (testosterone level <300 ng/dL). Secondary outcomes were risk of new prescription of PDE5-i or TRT.</p><p><strong>Results: </strong>Between 2005-2024, 30 964 patients with and 1 473 182 without cannabis diagnoses were identified with 29 442 in each cohort after matching. Between 2005-2020, 17 948 patients with and 839 496 without cannabis abuse/dependence were identified, with 17 211 in each cohort after matching. Cannabis abuse/dependence was significantly associated with ED (0.9% vs. 0.2%, RR = 3.99 [3.05, 5.21]), TD (0.2% vs. 0.1%, RR = 2.19 [1.45, 3.31]), and PDE5-i prescription (0.8% vs. 0.2%, RR = 3.80 [2.86, 5.04]) at 3 months-1 year, and only ED at 3-5 years (1.61% vs. 1.34%, RR = 1.20, 95% CI = [1.01, 1.43]). Kaplan-Meier analysis revealed significantly shorter time to development of ED (HR = 1.65, 95% CI = [1.47, 1.85]) and TD (HR = 1.34, 95% CI = 1.07, 1.69]) associated with cannabis abuse/dependence. No association between cannabis abuse/dependence and TRT was found. In those <40 years old, only ED and PDE5-i were significant at 3 months-1 year, but not at 3-5 years.</p><p><strong>Clinical implications: </strong>Our findings support an association between cannabis abuse/dependence, ED, and TD, which providers may consider when treating patients with these diagnoses.</p><p><strong>Strengths and limitations: </strong>Strengths include having a large, national sample of patients. Limitations include inability to assess dose-dependent relationships and using diagnosis codes as proxies for cannabis use.</p><p><strong>Conclusion: </strong>Cannabis abuse/dependence is associated with increased risk of ED, PDE5-i prescription, and TD.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online expressive writing intervention for the psychosexual well-being of women with a history of childhood sexual abuse: a randomized clinical trial.","authors":"Chelsea D Kilimnik, Cindy M Meston","doi":"10.1093/jsxmed/qdaf035","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf035","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sexual schema expressive writing that addresses nonconsensual sexual experiences has demonstrated initial support for improving psychosexual well-being for women with childhood sexual abuse (CSA) histories and is easily modifiable to an online modality for accessibility and scalability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The current study aimed to assess the online efficacy of a 5-session sexual schema expressive writing intervention against a daily events writing condition and an assessment-only condition for women with CSA histories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Women were initially randomized to 1 of the 2 active writing conditions (sexual schema, n = 73; daily events, n = 71); then, to minimize awareness of anticipated results, an assessment-only condition was recruited (n = 22). Outcomes were measured at baseline (T1), 3 weeks after baseline/posttreatment (T2), and at 1-month follow-up (T3). Additionally, participant-perceived change in sexual and psychological functioning across the course of the study was assessed at T2 and T3.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Outcomes included posttraumatic stress symptoms, sexual functioning, global self-esteem, and sexual self-concept.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Mixed effects linear regression models controlling for participant age demonstrated significantly greater rates of change in sexual functioning and sexual self-concept for both active writing conditions (sexual schema and daily events) in comparison with the assessment-only condition, with no differences across conditions in posttraumatic stress symptoms or self-esteem. Furthermore, analyses of variance controlling for age indicated that women in the sexual schema writing condition reported significantly greater perceived change in sexual well-being and psychological well-being than the assessment-only condition, though the daily events writing condition reported significantly greater perceived change only in psychological well-being as compared with the assessment-only condition.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;The current study provides evidence for the use of online modalities for expressive writing for women with CSA histories and supports the use of sexual schema writing paradigms for improving sexual well-being in this population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;The study is strengthened by its ecologically valid and diverse community sample and its rigorous multisession treatment protocol. The study is limited by being underpowered for some of its analyses. Additional research is needed on the daily events writing condition and ways to target more psychological outcomes in combination with sexual outcomes in online writing treatments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Online expressive writing paradigms that allow for guided reflection and space on how individuals' nonconsensual sexual experiences have affected their sexuality may be a fruitful strategy for many women to b","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous perineal urethroplasty and penile prosthesis explantation for urethral stricture and fractured malleable penile prosthesis through a single perineal incision: a case report and literature review.","authors":"Nazim Furkan Gunay, Fatih Yanaral, Omer Sarilar","doi":"10.1093/jsxmed/qdaf049","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf049","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring pain perception and depression in vulvodynia: the role of catastrophizing and pain acceptance.","authors":"Spinoni Marta, Cucurachi Giorgia, Porpora Maria Grazia, Grano Caterina","doi":"10.1093/jsxmed/qdaf046","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf046","url":null,"abstract":"<p><strong>Background: </strong>In the context of vulvodynia, a gynecological disorder characterized by chronic vulvar pain affecting an estimated 10% of women, with significant impacts on sexual health, mental well-being, and productivity, the Common-Sense Model of Illness Self-Regulation, a well-established framework for understanding the impact of illness perceptions and coping strategies on mental health, has not yet been empirically tested.</p><p><strong>Aim: </strong>We aimed to explore whether illness perceptions and pain-specific coping strategies-namely, pain catastrophizing and chronic pain acceptance-influence the relationship between vulvar pain severity and depression in women with vulvodynia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on a total of 119 women with reporting diagnosis of vulvodynia.</p><p><strong>Outcomes: </strong>Through an online questionnaire, we assessed demographic and clinical characteristics, vulvar pain severity, illness beliefs, pain catastrophizing, pain acceptance, and depressive symptoms.</p><p><strong>Results: </strong>The path analysis showed that vulvar pain positively influences directly illness perceptions (β = .56, P < .001) and depressive symptoms (β = .24, P < .001). Negative perceptions of the illness were significantly associated with increased pain catastrophizing (β = .66, P < .001), and decreased pain acceptance (β = -.59, P < .001), resulting in heightened depressive symptoms (β = .33, P < .001, β = -.27, P < .001, respectively).</p><p><strong>Clinical implications: </strong>Interventions that challenge negative illness perceptions and promote more positive views could reduce maladaptive coping strategies, enhance pain acceptance, and ultimately diminish psychological distress.</p><p><strong>Strengths and limitations: </strong>This study's strengths lie in its foundation on a theoretical, well-established model and the use of validated measures. However, the cross-sectional design precludes concluding causality between predictor and outcome variables, and the clinical information was self-reported and could not be verified with medical records.</p><p><strong>Conclusions: </strong>The findings underscore the importance of targeting illness perceptions and coping strategies in shaping psychological outcomes for women with vulvodynia.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between perceived stress and erectile function in patients with psychogenic erectile dysfunction: the mediating role of fatigue.","authors":"Zhi Cao, Tianle Zhu, Peng Yang, Yukuai Ma, Yunlong Ge, Pan Gao, Hui Jiang, Xiansheng Zhang","doi":"10.1093/jsxmed/qdaf045","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf045","url":null,"abstract":"<p><strong>Background: </strong>Psychological stress is closely linked to psychogenic erectile dysfunction (pED). In our recent clinical work, many pED patients report high levels of stress and fatigue, leading us to hypothesize these factors may play a contributory role in the development of pED.</p><p><strong>Aim: </strong>This research aims to elucidate how fatigue may mediate the connection between perceived stress and erectile function in individuals with pED.</p><p><strong>Methods: </strong>We assessed 125 patients diagnosed with pED. Erectile dysfunction severity was measured using the International Index of Erectile Function-5 (IIEF-5) and the Nocturnal Penile Tumescence and Rigidity (NPTR) tests. Perceived stress and fatigue were evaluated with the Perceived Stress Scale-14 and the Multidimensional Fatigue Inventory-20. Data were descriptively analyzed, and correlations among the 3 variables were examined. The mediating effect was assessed using the bootstrap method within the SPSS PROCESS macro.</p><p><strong>Outcomes: </strong>The outcomes include the relationship between perceived stress and erectile function and the mediating role of fatigue in patients with pED.</p><p><strong>Results: </strong>Our findings revealed a substantial negative correlation between perceived stress and erectile function (β = -0.604, P < .001). Fatigue emerged as a mediator in this relationship (β = -0.214, P < .05). The significance of the indirect effect of perceived stress via fatigue was confirmed through non-parametric bootstrapping (95% CI = -0.426 to -0.153), with fatigue contributing 26.46% to the total effect.</p><p><strong>Clinical implications: </strong>These findings have provided new ideas for interventions in the clinical management of pED, particularly for improving erectile function by simultaneously managing fatigue and stress.</p><p><strong>Strengths and limitations: </strong>This study explores the broader context of pED and provides a new perspective on the etiology of pED. The main drawback of this study is its lack of generalizability, as it was conducted within a monocultural and specific social context.</p><p><strong>Conclusion: </strong>Our findings of this study suggest that targeting both fatigue and perceived stress may be effective strategies for improving erectile function in patients with pED, providing valuable insights for research and clinical practice.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved psychosexual wellbeing with administration of combined Sildenafil plus Melatonin compared than either drug alone in management of women with polycystic ovarian syndrome: a 3-month randomized clinical study.","authors":"Zahra Asadi Kalameh, Maryam Abbasi, Seyed-Abdolvahab Taghavi, Fatemeh Bazarganipour","doi":"10.1093/jsxmed/qdaf028","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf028","url":null,"abstract":"<p><strong>Background: </strong>Given the significant impact of depression, sexual function, and health-related quality of life (HRQOL) in women with Polycystic Ovarian Syndrome (PCOS), it is crucial to identify scientifically supported interventions that enhance these outcomes and thereby promote HRQOL.</p><p><strong>Aim: </strong>The present study aimed to assess the effect of adjutant administration of Sildenafil plus Melatonin on psycho-sexual status in PCOS women undergoing Metformin in an Iranian population.</p><p><strong>Methods: </strong>This study was a randomized clinical trial. 216 Eligible women were assigned to four groups including Sildenafil plus Metformin, Melatonin plus Metformin, Melatonin plus Sildenafil and Metformin, and Metformin alone. The duration of intervention was 3 months.</p><p><strong>Outcomes: </strong>The Female Sexual Function Index, Hospital Anxiety and Depression Scale and modified PCOS health-related QOL questionnaire were used to evaluate sexual function, severity of depression and HRQOL, respectively.</p><p><strong>Results: </strong>Based on the results of the present study, statistically significant improvement was found in menstrual cyclicity, sexual function (desire and arousal), HRQOL concerning menstrual and emotional aspects and severity of depression between the groups before and after the intervention in Sildenafil plus Melatonin compared to other groups after 3 months (P < 0.05).</p><p><strong>Clinical implications: </strong>The present research determined administration of Sildenafil plus Melatonin enhances menstrual cyclicity status, mental well-being, sexual function, and HRQOL in women with PCOS who undergoing Metformin treatment.</p><p><strong>Strengths & limitations: </strong>The current research possesses several strengths, notably its adherence to the rigorous standards of a randomized controlled trial with well-defined initial inclusion criteria. In addition, this questionnaire is based on the previously ratified tools used. A robust sample size was maintained, enhancing the statistical power of the analysis. However, all the sample participants were sourced from a university referral clinic. Additionally, due to cultural norms, every participant in this study was married. Lastly, the absence of a post-intervention follow-up period is a notable gap; such a period could help determine the duration of the clinical effects or assess if ongoing treatment with Sildenafil plus Melatonin is necessary to sustain these effects.</p><p><strong>Conclusions: </strong>Findings from this initial randomized controlled trial indicate that a 12-week administration of Sildenafil plus Melatonin could enhance menstrual cyclicity status, reduce depression severity, and sexual function as well as HRQOL in women with PCOS who undergoing Metformin.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring subjective and genital sexual response in transgender women upon addition of low-dose testosterone to feminizing gender-affirming hormone therapy: a feasibility study.","authors":"Noor C Gieles, Baudewijntje P C Kreukels, Martin den Heijer, Stephanie Both","doi":"10.1093/jsxmed/qdaf041","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf041","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Transgender women using feminizing gender-affirming hormone therapy who underwent a gonadectomy generally have lower testosterone levels than cisgender women. It is unknown if testosterone supplementation can influence subjective and genital sexual response in transgender women and whether this can be measured using vaginal photoplethysmography.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aimed to assess the feasibility of measuring changes in subjective and genital sexual response in transgender women who underwent a penile inversion vaginoplasty after testosterone supplementation to physiological female concentrations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Transgender women received daily testosterone 2% transdermal gel, aiming for serum concentrations between 1.5 and 2.5 nmol/L for 12-20 weeks. Vaginal pulse amplitude (VPA) was measured during neutral, erotic fantasy, erotic film, and genital vibration stimulus blocks before and after testosterone supplementation. After each stimulus block, subjective sexual response was assessed. Sexual function, sexual excitability, and VPA measurement experience were assessed using questionnaires.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Change in mean VPA score and subjective sexual response after testosterone supplementation during neutral film, erotic fantasy, erotic film, and genital vibration.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eight participants were included of whom seven completed the study. VPA during neutral film was significantly higher after testosterone supplementation [estimated ratio 2.7 (95% confidence interval {CI} 1.7-4.3), P &lt; 0.001]. After testosterone supplementation, we observed no change in the degree of VPA response upon exposure to erotic fantasy [estimated ratio 1.4 (95% CI 0.68-2.8), P = 0.372], erotic film [estimated ratio 1.2 (95% CI 0.54-2.8), P = 0.629] and genital vibration [estimated ratio 1.2 (95% CI 0.46-2.9), P = 0.742] compared to before testosterone supplementation. After testosterone supplementation, participants reported significantly stronger feelings of sexual arousal, genital sensations, and positive affect in response to erotic fantasy and erotic film. Finally, there was a significant improvement in sexual function and sexual excitability assessed by questionnaires. VPA measurement was generally well-accepted.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Vaginal photoplethysmography can be used to assess changes in neovaginal perfusion in transgender women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths & limitations: &lt;/strong&gt;This is the first study assessing genital and subjective sexual response to testosterone supplementation in transgender women. The lack of a placebo condition precludes any clinical conclusions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Vaginal photoplethysmography can be used to assess changes in neovaginal vasocongestion after testosterone supplementation in transgender women. Explorative analyses suggest promising effects on subjective sexual response and a","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical malpractice after treatment of Peyronie's disease.","authors":"Zachary Boston, Imran Khawaja, Mahima Gurushankar, Meher Pandher, Aleksandar Popovic, Kunj Jain, Rhea Prabhu, Amjad Alwaal","doi":"10.1093/jsxmed/qdaf040","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf040","url":null,"abstract":"<p><strong>Background: </strong>Peyronie's Disease is a fibrotic tunica albuginea disorder resulting in penile deformity.</p><p><strong>Aim: </strong>This analysis provides an important investigation of medical malpractice cases related to the treatment of Peyronie's Disease.</p><p><strong>Methods: </strong>The LexisNexis+ and Westlaw databases were used to access all federal and state cases as well as jury verdicts and settlements. The databases were queried for the term \"Peyronie Disease\" and \"Peyronie's Disease\" between the years 1980 and 2024. One author manually reviewed all cases to find cases involving a patient suing the urologist or medical system after treatment for Peyronie's disease. Cases that did not sue the urologist in question and cases not directly pertaining to the consequences of Peyronie's disease were ruled out. Cases were categorized into reasons the plaintiff sued the defendant: infection, pain, deformity, erectile dysfunction, dysfunction of penile prosthesis, failure of informed consent, incorrect diagnosis, and improper surgical technique.</p><p><strong>Outcomes: </strong>The main outcome was which chief allegations commonly lead to medical malpractice litigation.</p><p><strong>Results: </strong>Investigation of the LexisNexis+ database yielded 76 cases. The Westlaw database offered 165 cases. After exclusion criteria, 22 cases were included from the LexisNexis+ database and an additional seven cases not identified in LexisNexis were included from Westlaw for a total of 29 cases. Fifteen of the cases ruled in favor of the defendant. Thirteen cases ruled in favor of the plaintiff with awards ranging from $97 500 to $3 971 917. The most common cause for litigation included dysfunction of a penile prosthesis, which was a precipitating issue in 37.9% of cases. Patients experiencing post-treatment infection were alleged in 34.5% of cases. Failure of informed consent was alleged in 20.7% of cases. Improper surgical technique was alleged in 20.7% of cases. Among the cases that ruled in favor of the plaintiff, the most common chief allegations included dysfunction of penile prosthesis, failure of informed consent, infection, improper surgical technique, erectile dysfunction, deformity, and incorrect diagnosis. 37.9% of cases originated from the southern region of the United States. Of the 13 cases that ruled in favor of the plaintiff, 38.5% were from the South and 38.5% were from the West.</p><p><strong>Clinical implications: </strong>Urologists remain at risk of encountering medical malpractice litigation after treatment of Peyronie's Disease.</p><p><strong>Strengths and limitations: </strong>We used strict inclusion criteria to ensure consistency of analysis Peyronie's disease treatment.</p><p><strong>Conclusion: </strong>This analysis identified that allegations were most common in Southern states, with the primary allegation being dysfunction of the penile prosthesis.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of female sexual dysfunctions on women undergoing pipelle endometrial biopsy and endocervical curettage for abnormal uterine bleeding: a prospective cross-sectional study.","authors":"Sevim Baltali, Ayşegül Ercan, Gonca Ceylan Kavsut, Rabia Göldağı, Gülen Kavsa, Elvan Çiftçi, Mehmet Baltali","doi":"10.1093/jsxmed/qdaf037","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf037","url":null,"abstract":"<p><strong>Background: </strong>Endometrial and endocervical biopsy sampling provides critical information for diagnosing and planning treatment in cases of abnormal uterine bleeding or suspected gynecological conditions. However, documented failure rates of up to one-third due to difficulties accessing the uterine cavity or insufficient histological sampling might have considerable clinical consequences.</p><p><strong>Aim: </strong>To assess the impact of female sexual dysfunction (FSD), depression, and anxiety on additional analgesic requirements (AAR), procedure failure (PF) due to endometrial inaccessibility, and biopsy failure (BF) among women undergoing pipelle endometrial biopsy and endocervical curettage (PEB- ECC).</p><p><strong>Methods: </strong>This prospective study collected data through face-to-face interviews with 417 women who underwent PEB-ECC between November 2022 and 2023. Anxiety and depression were evaluated using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI), respectively. Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) criteria were used to assess FSD and its related components. Age, body mass index, and educational level were considered potential confounders.</p><p><strong>Outcome: </strong>Outcomes included the necessity for additional analgesics during the surgical process, PF attributed to challenges in accessing the uterine cavity, and BF resulting from inadequate histological sampling.</p><p><strong>Results: </strong>A BAI score > 9, age ≥ 55 years, and the presence of FSD were independent predictors of AAR during PEB-ECC. PEB-ECC sampling failed in 71 women (17.0%), with PF in 7 (1.7%). Univariate analysis showed that only genito-pelvic pain/penetration disorder was associated with PF. Age ≥ 55 years and FSD were significant predictors of BF. Female orgasmic disorder was associated with BF as a component of FSD.</p><p><strong>Clinical implications: </strong>Our findings highlight the significance of FSD in influencing the success of endometrial and endocervical biopsy sampling, which gynecologists and anesthesiologists should consider before and during the procedure.</p><p><strong>Strengths and limitations: </strong>This study is the first to assess the impact of FSD on the success of PEB-ECC procedures. Intercultural variation exists in the prevalence and predictors of FSD; therefore, our findings should be interpreted cautiously. Validation studies remain warranted. We evaluated the presence and components of FSD during the interviews rather than its severity; the low response rate (417 [25.3%]) might have impacted the results.</p><p><strong>Conclusion: </strong>Despite sufficient sedation/analgesia, FSD significantly influenced AAR, PF, and BF in women undergoing PEB-ECC. Anesthesiologists and gynecologists should consider additional factors to improve the success of sampling procedures.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}