Journal of Sexual Medicine最新文献

{"title":"Response to Letter to the Editor: medical podcasts.","authors":"","doi":"10.1093/jsxmed/qdaf157","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf157","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: medical podcasts.","authors":"Vahid Mohammadpour Karizaki","doi":"10.1093/jsxmed/qdaf154","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf154","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of mental health evaluation in erectile dysfunction clinical trials.","authors":"Maya Morcos, Bassam Jeryous Fares, Amir-Ali Golrokhian-Sani, Marc Morcos, Ryan Flannigan, Rodney H Breau, Luke Witherspoon","doi":"10.1093/jsxmed/qdaf173","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf173","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is commonly psychogenic or may cause psychological issues, such as anxiety and depression. Nevertheless, the inclusion of mental health (MH) assessment in ED clinical trials has yet to be quantified.</p><p><strong>Aim: </strong>To evaluate the prevalence of MH evaluation in ED clinical trials.</p><p><strong>Methods: </strong>The brief and detailed descriptions from every clinical trial concerning ED from the US National Library of Medicine ClinicalTrials.gov database were extracted.</p><p><strong>Outcomes: </strong>The number of studies which mention the terms \"self-esteem\", \"anxiety\", \"depression\", \"schizophrenia\", \"emasculation\", \"humiliation\", \"isolation\", \"loneliness\", \"frustration\", \"OCD\", \"PTSD\", \"ADHD\", \"SUD\", \"BPD\", \"autism\", \"bipolar\", \"dementia\", \"phobia\", \"mania\", \"anorexia\", \"bulimia\", \"insomnia\", and \"delirium\" were assessed.</p><p><strong>Results: </strong>In total, 453 clinical trials were included from 1988 to 2024. Only seven of the searched MH terms were present in any clinical trial: stress (n = 3), self-esteem (n = 11), anxiety (n = 15), depression (n = 17), bipolar (n = 1), insomnia (n = 1), and isolation (n = 1). There was no temporal improvement in the prevalence of MH terms over time.</p><p><strong>Clinical implications: </strong>The limited inclusion of MH terms underscores a potential gap in addressing the psychological dimensions of ED in a clinical setting. Such considerations may enhance patient care by improving diagnosis and MH outcomes.</p><p><strong>Strengths and limitations: </strong>This study employs a replicable methodology using automated data extraction to quantify MH representation in ED trials. However, limitations include strict word-matching and an inability to extract word-context.</p><p><strong>Conclusion: </strong>MH terms are infrequently included in ED clinical trials, which may reflect a lack of research interest in the association between ED and MH.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile cavernosal artery calcification is associated with diabetes mellitus, peripheral arterial disease, and cerebrovascular accidents, but not erectile dysfunction.","authors":"Leila Momtazi-Mar, Maharshi Rajdev, Bryan D Naelitz, Kevin Yin, Marcelo Mass Lindenbaum, Scott D Lundy, Ashish Sarraju, Karunakaravel Karuppasamy, Petar Bajic, Raevti Bole","doi":"10.1093/jsxmed/qdaf174","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf174","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Examining gender-specific mental health risks after gender-affirming surgery: a national database study\".","authors":"Sarah C J Jorgensen","doi":"10.1093/jsxmed/qdaf159","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf159","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of adverse effects of combined and isolated substances in Intracavernosal injection: a systematic review and meta-analysis.","authors":"Arthur Santos Lima, Beatriz de Carvalho Villela, Hugo Nunes Pustilnik, Letícia Freire de Carvalho Mattos, Vanessa Pinheiro Coelho de Sá, Filip Messias Santana Prado, Lucas Teixeira Batista","doi":"10.1093/jsxmed/qdaf172","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf172","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a highly prevalent condition that significantly impairs quality of life, and while intracavernosal injection (ICI) therapy remains an effective treatment option, it is frequently associated with adverse effects such as pain, priapism, and penile fibrosis.</p><p><strong>Objectives: </strong>The aim of this study was to review observational and randomized studies and compare the adverse effects of intracavernosal injection therapy using isolated and combined substances.</p><p><strong>Methods: </strong>Observational and randomized studies published up to November 11, 2024 were searched in Medline (PubMed), EMBASE, and Cochrane Library. Twelve studies were included in the review, of which 5 were randomized clinical trials (RCTs) and 7 were non-RCTs, and of these 9 were included in meta-analysis. All of them evaluate the presence of side effects when administering drugs via ICI.</p><p><strong>Outcomes: </strong>The primary outcomes were adverse effects, including pain, priapism, and fibrosis.</p><p><strong>Results: </strong>As results, the variable \"pain\" did not show a significant difference between the groups (OR: 0.68, 95% CI: 0.03-18.14, P = 0.82). \"Priapism\" had a significant result when analyzing all articles together, having minimal presence in the isolated group (OR: 1.84, 95% CI: 1.03-3.20, P = 0.04), however when analyzing only the RCTs there was no significant difference between the groups. Only four studies analyzed fibrosis as an outcome, with rates ranging from 0.8% to 15%. Notably, only two studies assessed fibrosis separately between the \"combined drugs\" and \"isolated\" groups, reporting varying rates across these categories. Clinical implications: These findings emphasize the need for individualized treatment strategies in intracavernosal therapy, as no consistent advantage was observed for combination therapy over monotherapy in minimizing adverse effects.</p><p><strong>Strengths and limitations: </strong>The main limitations of this study were the small number of available articles and the lack of more recent publications on the topic.</p><p><strong>Conclusion: </strong>This study reviewed the main adverse effects of intracavernosal injection therapy for ED, emphasizing the need for a personalized approach, as no significant differences were observed between monotherapy and combination therapy regarding pain, fibrosis, and priapism.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health outcomes following gender-affirming phalloplasty: a systematic review.","authors":"Jennifer Zack, Benjamin Goldstein, Kyle Okamuro, Priya Lewis, Jennifer Anger, Maria Uloko","doi":"10.1093/jsxmed/qdaf166","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf166","url":null,"abstract":"<p><strong>Background: </strong>Sexual function is a crucial factor in achieving optimal sexual health and is typically assessed by one's ability to achieve desire, arousal and orgasm. The majority of genital gender-affirming surgery literature has focused on urologic or esthetic outcomes, with less emphasis on sexual function.</p><p><strong>Aim: </strong>We sought to systematically review studies assessing sexual health outcomes of phalloplasty in the transmasculine population to elucidate our current understanding of the range of sexual health outcomes studied and to identify knowledge gaps.</p><p><strong>Methods: </strong>Studies on sexual function in transmasculine patients were systematically identified using PubMed, Embase, and Web of Science searches from database origins through February 29, 2024 based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement.</p><p><strong>Results: </strong>Eighteen articles met the criteria for inclusion. Arousal/desire outcomes ranged from 5.4% of patients with difficulty with arousal to 77% of patients with reduced arousal to half the time or less. Studies varied widely in assessment, but the majority reported ratings of erogenous sensation to be between 53% and 100%. The ability to orgasm ranged from 50%-93% during masturbation, 58%-75% during intercourse with a partner, and 29%-100% when asked generally. The ability to engage in penetrative intercourse ranged between 19% and 100%, and often included people who had not received penile implants. The absence of pre-surgical data limits our ability to assess whether the reported post-operative outcomes reflect an improvement in sexual health.</p><p><strong>Conclusion: </strong>This review revealed differences in sexual function based on phalloplasty technique. Specifically, the largest post-op increase in desire was after radial forearm free flap (RFFF). Roughly half of patients who underwent phalloplasty with either RFFF or suprapubic pedicle reported the ability to achieve orgasm. Most patients reported penetrative ability with a penile implant, though patients did endorse penetration without an implant. Future studies are needed with outcome measures that have been validated within the transmasculine population and with more granular information regarding ancillary procedures, donor sites, and type of nerve coaptation.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction in adult men in the United States: C-reactive protein-triglyceride-glucose index, evidence from NHANES 2001-2004 data.","authors":"Haoqiang Bai, Wei He, Yi Wang","doi":"10.1093/jsxmed/qdaf175","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf175","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness and daily sexual function: a dyadic diary study.","authors":"Emily Jarvis, Jackie S Huberman, Natalie O Rosen","doi":"10.1093/jsxmed/qdaf167","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf167","url":null,"abstract":"<p><strong>Background: </strong>Difficulties with sexual function are common with implications for couples' psychological and relationship well-being. Sexual mindfulness (ie, non-judgmental present-moment awareness during sexual activity) has been positively linked to sexual function in cross-sectional studies, but associations in the context of couples' daily lives are lacking.</p><p><strong>Aim: </strong>The aim of this study was to determine if higher levels of baseline sexual mindfulness predict one's own and one's partner's daily sexual function.</p><p><strong>Methods: </strong>In a dyadic daily diary study, an inclusive sample of 141 couples completed a measure of sexual mindfulness at baseline and reported on their sexual function daily, on days of sexual activity, for 28 days.</p><p><strong>Outcomes: </strong>Daily sexual function was assessed with the Monash Sexual Satisfaction Questionnaire.</p><p><strong>Results: </strong>Higher sexual mindfulness at baseline was associated with one's own, but not one's partner's, higher daily sexual function.</p><p><strong>Clinical implications: </strong>Targeting sexual mindfulness in sex therapy may promote an individual's own daily sexual function.</p><p><strong>Strengths & limitations: </strong>This study employed a daily diary assessment of sexual function, which reduces recall biases and promotes ecological validity. We were limited by not having a daily measure of sexual mindfulness, rather we focused on a trait-like assessment of sexual mindfulness.</p><p><strong>Conclusion: </strong>Sexual mindfulness may support present-moment awareness in day-to-day sexual interactions, thus promoting daily sexual function. This may be largely an individual process, as there were no partner effects, although it is relevant that higher sexual mindfulness was not associated with drawbacks for partner sexual function. These findings provide empirical support for mindfulness therapies for sexual function.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in blood-based metabolic and cardiovascular risk profiles in men during treatment for testosterone deficiency: a longitudinal, retrospective cohort study.","authors":"Ashley Kieran Clift, David R Huang, Nadja Auerbach, Vivian N Liu, Hans Johnson, Mohit Khera","doi":"10.1093/jsxmed/qdaf170","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf170","url":null,"abstract":"<p><strong>Background: </strong>Cross-sectional analyses demonstrate associations between lower endogenous testosterone, poorer metabolic health, and cardiovascular risk. However, the longitudinal associations between treating testosterone deficiency (TD) and key markers are unclear.</p><p><strong>Aim: </strong>To examine 12-month trends in total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), haemoglobin A1c (HbA1c), triglycerides, and triglyceride:HDL ratios during treatment for TD.</p><p><strong>Methods: </strong>This retrospective cohort study used mixed effects models to assess marker trajectories.</p><p><strong>Outcomes: </strong>Absolute and percentage changes calculated from average marker values at 0 and 12 months (overall and sub-groups).</p><p><strong>Results: </strong>The cohort comprised 4307 men (median age 41 years; baseline BMI 28.4 kg/m2). No significant changes were observed in LDL. The average HDL level at baseline was 1.26 mmol/L (95% CI: 1.25 to 1.26), decreasing to 1.15 (95% CI: 1.10 to 1.20) at 12 months, a relative change of -8.73% (P < 0.001). There was a 1.55 mmol/mol (95% CI: -2.74 to -0.36) average reduction in HbA1c over 12 months (relative change -4.46%, P = 0.011). The average triglyceride level was 2.25 mmol/L at baseline (95% CI: 2.20 to 2.28) and 1.79 mmol/L (95% CI: 1.55 to 2.04) at 12 months, a relative change of -20.09% (P < 0.001). Men with elevated baseline triglycerides had marked reductions, from 3.13 mmol/L at baseline to (95% CI: 3.67 to 3.79) to 2.29 mmol/L at 12 months (95% CI: 1.90 to 2.68), relative change -26.84% (P < 0.001). There was a positive relationship between baseline triglyceride:HDL elevation and relative reductions; in men with a baseline ratio > 6, values went from 8.99 at baseline (95% CI: 8.80 to 9.18) to 1.90 (95% CI: 0.19 to 3.61) at month 12, a relative change of -78.86% (P < 0.001).</p><p><strong>Clinical implications: </strong>In this non-randomized study, significant reductions in HDL, HbA1c, triglycerides, and the triglyceride:HDL ratio were observed during the course of treatment for TD.</p><p><strong>Strengths & limitations: </strong>The study used a large cohort of men and explored clinically relevant sub-groups, albeit from a single healthcare provider.</p><p><strong>Conclusions: </strong>Interventions for TD could have potential to improve longer-term cardiometabolic health in hypogonadic men. Large, prospective, controlled studies are needed to identify the causal contributions from TD treatment strategies and lifestyle changes on biochemical marker improvements.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}