Journal of Sexual Medicine最新文献

{"title":"Sexual functioning after risk-reducing oophorectomy: a prospective study.","authors":"Tami S Rowen, John Boscardin, Lee-May Chen, Mindy Goldman, Vanessa Jacoby","doi":"10.1093/jsxmed/qdaf183","DOIUrl":"10.1093/jsxmed/qdaf183","url":null,"abstract":"<p><strong>Background: </strong>Several studies have suggested a decrease in sexual function after risk-reducing salpingo-oophorectomy (RRSO) that is not mitigated by hormone therapy treatment.</p><p><strong>Aims: </strong>This is a prospective cohort study of women followed from the time of diagnosis, including those who chose whether to proceed with RRSO, and changes in sexual function.</p><p><strong>Methods: </strong>Premenopausal women were recruited from a high-risk cancer genetics clinic at a large academic center and completed detailed demographics and validated measures regarding their physical, mental, and sexual health.</p><p><strong>Outcomes: </strong>Women were surveyed over the course of 60 months, using the Sexual Health Outcomes in Women Questionnaire (SHOW-Q), and results were analyzed, controlling for known confounders in sexual health, comparing women with and without RRSO.</p><p><strong>Results: </strong>One hundred women completed the study, 99 of whom completed baseline SHOW-Q surveys. Forty-one women planned RRSO at the beginning of the study, and another 30 underwent an RRSO during the study period. At baseline, women who underwent RRSO had lower sexual functioning scores in terms of sexual satisfaction and pelvic problem interface. Over 60 months, there was no difference in sexual function scores between the RRSO and the no-RRSO group in multivariable models that adjusted for depression, hormone use, menopausal symptoms, or other confounders.</p><p><strong>Clinical implications: </strong>Pre-surgery sexual function predicts post-surgery sexual function, which challenges existing dogma, and women can be reassured that surgery likely won't affect sexual function.</p><p><strong>Strengths and limitations: </strong>This study's strength was the relatively large sample size and long-term follow-up. Limitations were a relatively homogeneous population that may not reflect the diversity of patient experiences.</p><p><strong>Conclusions: </strong>These findings can be useful to providers and patients in understanding the effects of surgery and are reassuring that sexual function may, in fact, not be worsened by surgery.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1606-1611"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective study of endogenous testosterone recovery following neoadjuvant hormonal blockade and radical prostatectomy in high-risk prostate cancer patients.","authors":"Bruno Chiesa G Nascimento, Rubens Pedrenho, Pedro C E Zandoná, Lucas V Sanvido, José Bessa Junior, Eduardo de P Miranda, Diogo A Bastos, Mauricio D Cordeiro, Rafael Coelho, William C Nahas, Jorge Hallak, John P Mulhall, Cristiano M Gomes","doi":"10.1093/jsxmed/qdaf164","DOIUrl":"10.1093/jsxmed/qdaf164","url":null,"abstract":"<p><strong>Background: </strong>Recovery of endogenous testosterone following androgen deprivation therapy (ADT) for prostate cancer is uncertain.</p><p><strong>Aim: </strong>To prospectively evaluate testosterone (T) recovery rates and timing after neoadjuvant ADT followed by radical prostatectomy (RP).</p><p><strong>Methods: </strong>We report a secondary analysis from a phase II randomized trial involving 64 patients who received a 3-month neoadjuvant ADT regimen (goserelin, abiraterone with prednisone and for half of the participants, apalutamide) followed by RP. Total Testosterone (TT) was measured at baseline, during ADT (3 m), and after 4, 8, and 12 months post-ADT cessation. Return to non-castrate levels (TT > 50 ng/dL), to normal (TT ≥ 300 ng/dL), and back to baseline level (BTB, defined as TT ≥ baseline) are reported. Predictive factors were analyzed using uni and multivariate analyses (MVA), and quality of life (QoL) was assessed with the validated Expanded Prostate Cancer Index Composite (EPIC-50).</p><p><strong>Outcomes: </strong>Chance and chronology of T recovery 1 year after ADT cessation.</p><p><strong>Results: </strong>Median T levels were as follows: baseline 442 ng/dL (IQR: 321-505); 4 months post-ADT, 144 ng/dL (IQR: 35-284); 8 months, 316 ng/dL (IQR: 243-438); and 12 months, 358 ng/dL (IQR: 285-477). By 12 months, 98.1% of patients reached non-castrate levels, 79.5% returned to normal, and 33.9% to BTB. Half of the patients achieved T > 50 ng/dL in 5 months, T ≥ 300 ng/dL in 9.1 months, and BTB in 13.1 months. In MVA, baseline T was the only significant predictor for T normalization (OR: 1.015; P < .01), while age and baseline T were predictors for BTB recovery (OR for age: 0.88; P = .02; OR for baseline T: 0.99; P = .02). QoL assessment showed persistently low sexual function, with minor improvements over time (median scores: 0 [0-5.6] at 4 months and 2.8 [0-29.2] at 12 months, P < .01), while sexual bother starts very low but significantly increases during follow up (median scores: 100 [IQR: 42.2-100] at 4 months to 50 [IQR: 0-100] at 12 months, P = .03).</p><p><strong>Clinical implications: </strong>Long-term lower T levels can occur even after short-term ADT, persisting longer than anticipated. Clinicians should consider this in patient management.</p><p><strong>Strengths and limitations: </strong>Our strengths include the prospective, controlled design and a rarely reported ADT triple therapy followed by RP. Limitations include the use of immunoassay to measure TT.</p><p><strong>Conclusion: </strong>After 3 months of neoadjuvant triple ADT and RP, significant recovery to non-castrate and normal T levels is seen in most patients by 1 year; yet, BTB recovery is achieved in only a third. Higher baseline T and younger age predict faster T normalization and BTB recovery, respectively.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1554-1563"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Examining gender-specific mental health risks after gender-affirming surgery: a national database study\".","authors":"Zeki Bayraktar","doi":"10.1093/jsxmed/qdaf162","DOIUrl":"10.1093/jsxmed/qdaf162","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1708-1709"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peyronie's disease and risk of depression. A nationwide 25-year cohort study.","authors":"Sophie Løfvall Lindhardt-Mejlholm, Katrine Schmidt Mortensen, Ina Trolle Andersen, Mette Nørgaard, Lars Lund","doi":"10.1093/jsxmed/qdaf168","DOIUrl":"10.1093/jsxmed/qdaf168","url":null,"abstract":"<p><strong>Background: </strong>Peyronie's disease leads to penile deformities and can cause physical symptoms, for example, penile pain, and erectile dysfunction, along with psychological issues, such as depressive symptoms.</p><p><strong>Aim: </strong>The aim of this study was to investigate whether men with Peyronie's disease have an increased risk of depression.</p><p><strong>Methods: </strong>This nationwide cohort study included men with Peyronie's disease (ICD-10 code: N486) from 1997 to 2021 and age-matched (1:10) men without Peyronie's disease. We obtained complete medical history before the Peyronie's disease diagnosis/index date. We followed both cohorts for depression. We computed the cumulative incidence of depression at 5 and 10 years of follow-up and estimated hazard ratios for depression comparing the 2 cohorts while adjusting for selected chronic diseases using Cox regression.</p><p><strong>Outcome: </strong>The primary outcome, depression, was defined by ICD-10 code: F32, F33 recorded in the Danish National Patient Registry or the Psychiatric Central Research Registry and/or redemption of at least 2 prescriptions for an antidepressant (ATC-code: N06A).</p><p><strong>Results: </strong>We included 10 053 men with Peyronie's disease and 100 530 without (median age 55.6 years). At the index date, 19.6% men with Peyronie's disease had depression versus 14.0% men without. At baseline, men with Peyronie's disease had a 5-year risk of depression of 7.0% versus 4.4% in men without, while the 10-year risks were 12.5% and 8.7%, respectively. The adjusted hazard ratio was 1.42 (95% CI, 1.32, 1.52).Men with Peyronie's disease had a 10-year all-cause mortality of 5.9%, while it was 9.1% in men without.</p><p><strong>Clinical implications: </strong>Health professionals should ensure that men with Peyronie's disease are examined for depression.</p><p><strong>Strengths and limitations: </strong>A limitation of our study is the potential underdiagnosis of men with Peyronie's disease, which may lead to an incorrect estimation of depression among Peyronie's disease patients. It is a strength that we include a nationwide cohort of men with Peyronie's disease and age-matched controls. Other strengths are that we included information from several Danish medical databases and depression was defined as a clinic diagnosis and/or redemption of at least 2 prescriptions for an antidepressant.</p><p><strong>Conclusions: </strong>Men with Peyronie's disease had a higher prevalence of depression at the time of diagnosis and a higher risk of depression following diagnosis compared with men without.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1640-1646"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Nut November, temporary abstinence, and sexual wellbeing: a study of the short-term abstinence-based internet trend.","authors":"Melody Garas, Samantha L Levang, Caroline F Pukall","doi":"10.1093/jsxmed/qdaf165","DOIUrl":"10.1093/jsxmed/qdaf165","url":null,"abstract":"<p><strong>Background: </strong>No Nut November (NNN) is a mainstream Internet challenge wherein participants attempt to avoid masturbation, or ejaculation as a result of masturbation, for the month of November.</p><p><strong>Aim: </strong>We investigated the trend and its participants, as well as the sexual outcomes of participating in NNN in a diverse sample.</p><p><strong>Methods: </strong>This online survey study collected detailed sociodemographic information and data on sexual wellbeing at 2 time points, before and after NNN from those who do and do not engage in NNN. Data from 435 individuals at T1 and 114 individuals at T2 were analyzed via descriptives, ANCOVAs, and repeated measure ANOVAs.</p><p><strong>Outcomes: </strong>Main outcome measures were Sexual Pleasure Scale for sexual pleasure, Sexual Desire Inventory-Solitary subscale for solitary desire, Arizona Sexual Experience Scale for sexual dysfunction, SexFlex Scale for sexual flexibility, and Sexual Excitation Scale-SF for sexual excitation.</p><p><strong>Results: </strong>Compared to those who had never participated in the trend, NNN participants reported increased sexual flexibility; however, over a period of abstinence, no measures of sexual wellbeing significantly differed in NNN participants compared to non-participants.</p><p><strong>Clinical implications: </strong>Sexual flexibility may be associated with a willingness to attempt different trends and sexual practices. A period of abstinence may not be associated with improved or worsening sexual wellbeing.</p><p><strong>Strengths and limitations: </strong>Although the present study provides the first investigation of NNN and results indicate no impact after a period of abstinence on sexual wellbeing outcomes, more longitudinal research examining outcomes of abstinence is needed.</p><p><strong>Conclusions: </strong>These findings may have important implications regarding current practices related to NNN and the increasing role of social media challenges on people's sexual behavior.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1649-1657"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor on \"Examining gender-specific mental health risks after gender-affirming surgery: a national database study\".","authors":"Joshua E Lewis","doi":"10.1093/jsxmed/qdaf161","DOIUrl":"10.1093/jsxmed/qdaf161","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1714-1715"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Maximizing postoperative satisfaction in penile prosthesis surgery: the predictive power of preoperative length and its role in tailoring enhancement procedures.","authors":"","doi":"10.1093/jsxmed/qdaf208","DOIUrl":"10.1093/jsxmed/qdaf208","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1717"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"They have just as much right to learn\": Mother's perceptions of sexual and reproductive health communication with daughters with a physical disability and preferences for an intervention.","authors":"Courtney S Streur, Jodi M Kreschmer, Rebecca Howland, Monica W Rosen, Daniela A Wittmann, Claire Z Kalpakjian","doi":"10.1093/jsxmed/qdaf180","DOIUrl":"10.1093/jsxmed/qdaf180","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1551-1553"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Evidence-Based Management Guidelines on Peyronie's Disease.","authors":"","doi":"10.1093/jsxmed/qdaf219","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf219","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between erectile dysfunction onset timing, online information seeking behavior, and International Index of Erectile Function-5 severity scores.","authors":"Hector Rodrigo Gonzalez-Carranza, Ricardo Ramón Tinoco-Betancourt, Luis Antonio Reyes-Vallejo","doi":"10.1093/jsxmed/qdaf218","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf218","url":null,"abstract":"<p><strong>Background: </strong>The easy access to the Internet through smartphones leads to the immediate search for information when experiencing erectile dysfunction (ED) symptoms, and this can lead to late medical attention.</p><p><strong>Aim: </strong>This study assesses to identify the time between the onset of ED symptoms and the first time medical consultation and its correlation with searching for information on the Internet.</p><p><strong>Methods: </strong>Data were collected using validated questionnaires and clinical interviews.</p><p><strong>Outcomes: </strong>Search for information on the Internet, International Index of Erectile Function-5 severity score, time between onset of symptoms, and first time medical appointment were analyzed. Relations were stablished using t-test.</p><p><strong>Results: </strong>Among 202 men, the average time between the onset of symptoms and first time medical appointment was 30.7 months. There is a correlation between ED severity and the first time medical appointment (P < .01). There is a statistically significant relationship between time for first medical appointment and searching for information on the Internet (P < .01). Patients who look for information on the Internet take less time for a first time medical appointment, unless they have severe ED (29.2 vs. 33.12 months).</p><p><strong>Clinical implications: </strong>Medical information on the Internet should be trustworthy and lead the patients to attend medical consultation and diminish sexual dissatisfaction.</p><p><strong>Strengths and limitations: </strong>Strengths include demographic heterogeneity, knowing the characteristics of the information found on the Internet, and a robust methodology. Limitations include the cross-sectional design and the sample size.</p><p><strong>Conclusions: </strong>The availability of information on the Internet, often lacking scientific backing, has been identified as a factor contributing to delays in seeking professional care, with consequent risks to the patient's health. The significant delay observed in seeking medical consultation after the onset of ED suggests the existence of barriers that are not yet fully understood and warrant further in-depth study.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}