Journal of Sexual Medicine最新文献

{"title":"Response to Letter to the Editor on \"The impact of elective adult circumcision for religious reasons on sexual function and satisfaction: a pilot study\".","authors":"May Fihman, Dolev Peretz, Mahmood Abbas, Yehuda Noyman, Boris Chertin, Binyamin B Neeman","doi":"10.1093/jsxmed/qdag094","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag094","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic itinerary of patients with erectile dysfunction until the indication for penile prosthesis implantation: a cross-sectional study.","authors":"Margareth de Mello Ferreira Dos Reis, Maria Beatriz Gracia Molina, Ana Claudia Fernandes Oliveira, Marilisa Pollone, Valéria Medeiros da Silva, Marília Rangel Machado, Eduardo Augusto Corrêa Barros, Sidney Glina","doi":"10.1093/jsxmed/qdag085","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag085","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant administration probiotic effects on sexual function in depressant men undergoing selective serotonin reuptake inhibitor treatment: a double-blinded randomized controlled trial.","authors":"Seyed-Abdolvahab Taghavi, Mohammad Sadri, Mahdyeh Hashemimohammadabad, Nazir Hashemimohammadabad, Zeinab Hashemimohammadabad, Fatemeh Bazarganipour","doi":"10.1093/jsxmed/qdag043","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag043","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common psychiatric disorder worldwide, often linked to complications like impaired sexual function.</p><p><strong>Aim: </strong>To determine the effect of the probiotic Lactofem combined with Escitalopram on severity of depression and sexual function in men diagnosed with mild to moderate depression undergoing SSRI treatment.</p><p><strong>Methods: </strong>In a randomized controlled trial, 240 men with mild to moderate depression were assigned to 2 groups. The intervention group (119 participants) received Lactofem alongside Escitalopram, while the control group (121 participants) received only Escitalopram for 2 months.</p><p><strong>Outcomes: </strong>Depression severity was measured by the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Sexual function was assessed using the International Index of Erectile Function (IIEF) questionnaire at baseline and after treatment.</p><p><strong>Results: </strong>Both groups showed significant improvement in depression scores (P < .05). The Lactofem group had a greater reduction in HDRS (6.42 ± 3.45 vs 8.61 ± 4.15, P < .05) and BDI scores (27.63 ± 4.13 vs 30.24 ± 4.51, P < .05). Sexual function improvements were significantly higher in the intervention group across all domains: erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction (all P < .05).</p><p><strong>Clinical implications: </strong>Probiotics such as Lactofem may offer benefits as adjunctive therapy to reduce depression symptoms and improve SSRI-induced sexual dysfunction.</p><p><strong>Strengths and limitations: </strong>Strengths include a rigorous randomized design, validated tools, and large sample size. Limitations are recruitment from a single Iranian clinic with culturally homogenous, married men, absence of placebo, young patient age, and no long-term follow-up.</p><p><strong>Conclusion: </strong>Adding Lactofem to Escitalopram treatment significantly reduces depression severity and enhances sexual function in men with mild to moderate depression.</p><p><strong>Clinical trial number: </strong>IRCT20160524028038N14, Registration Date: 2024-05-17.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: https://irct.behdasht.gov.ir/trial/67103.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single center experience with tunica expansion procedure (TEP) for penile length recovery: a report on objective outcomes and patient satisfaction.","authors":"Jacob Rubin, Sameer Ansari, Gabriana Farah, Laurence Levine","doi":"10.1093/jsxmed/qdag110","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag110","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported penile sensory loss, not surgical approach, is associated with sexual satisfaction after inflatable penile prosthesis implantation.","authors":"Abdullah Akdag, Enes Aktas, Halil Lütfi Canat","doi":"10.1093/jsxmed/qdag107","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag107","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Postoperative penile sensory changes are frequently reported after penile prosthesis implantation, yet their impact on sexual satisfaction remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To determine whether patient-reported penile sensory loss independently predicts postoperative sexual satisfaction and to compare outcomes between penoscrotal and infrapubic approaches.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective single-center observational study included 159 men undergoing three-piece inflatable penile prosthesis (IPP) implantation with ≥9 months of follow-up; patients with neurological conditions affecting genital sensation were excluded. Clinical, hormonal, Doppler, perioperative, and postoperative data were collected, sexual satisfaction was assessed using the New Sexual Satisfaction Scale (NSSS), and penile sensory loss was evaluated separately using a single-item binary patient-reported question administered during face-to-face interviews (\"Do you currently experience loss of penile sensation?\"), reflecting present postoperative perception. Predictors of NSSS were analyzed using univariate and multivariate linear regression, and outcomes between surgical approaches were compared using Mann-Whitney U, Chi-square, or Fisher's exact tests.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The primary outcome was postoperative sexual satisfaction (NSSS), and secondary outcomes included penile sensory loss, operative time, hospital stay, Clavien-Dindo complications, and prosthesis malfunction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Penile sensory loss was the only independent predictor of lower NSSS scores (β = -17.72; 95% CI -22.13 to -13.31; P &lt; .001), while age, BMI, Charlson Comorbidity Index, erectile dysfunction etiology, smoking exposure, complications, and device malfunction were not independently associated with satisfaction (all P &gt; .05). No significant differences were observed between penoscrotal and infrapubic approaches in postoperative sensory loss (P = .234), NSSS scores (P = .181), operative time (P = .170), or hospital stay (P = .406), although the penoscrotal approach showed a higher overall rate of Clavien-Dindo complications (76.5% vs. 43.5%, P &lt; .001), this difference was predominantly driven by low-grade (Grades I-II) events rather than clinically severe complications, with identical malfunction rates between groups (17.6% vs. 17.6%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Penile sensory perception significantly influences postoperative sexual satisfaction and should be routinely evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Strengths include a relatively large cohort and use of a multidimensional validated satisfaction measure, while limitations include the retrospective design, reliance on subjective sensory reporting, and absence of long-term follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patient-reported penile sensory perception showed the strongest independent association with sexual ","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulated FTO promotes TNIP1 m6A demethylation induced penile corpus cavernosum endothelial pyroptosis and erectile dysfunction in type 2 diabetic rats.","authors":"Chunyang Meng, Jun Jiang, Rui Jiang","doi":"10.1093/jsxmed/qdag119","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag119","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a prevalent complication of type 2 diabetes mellitus (T2DM). However, the role of RNA N6-methyladenosine (m6A) methylation in T2DM-associated ED remains unclear.</p><p><strong>Aim: </strong>To determine whether m6A demethylation of TNFAIP3-interacting protein 1 (TNIP1) RNA mediated by fat mass and obesity-associated protein (FTO) regulates pyroptosis in corpus cavernosum endothelial cells in T2DM and contributes to ED.</p><p><strong>Methods: </strong>The endothelial cells of the penile corpus cavernosum were obtained from Sprague-Dawley (SD) rats aged 8 weeks and assigned to five groups as follows: Control group, KD-FTO group that treated with the FTO-targeting siRNA lentivirus, OE-FTO group that treated with the FTO-overexpression lentiviral vector, KD-NC group that treated with the control siRNA lentivirus, and OE-NC group that treated with the empty FTO-overexpression lentiviral vector. The levels of FTO, TNIP1, NFκB, caspase-1, p-eNOS/eNOS, and NO were measured. TNIP1 mRNA stability was assessed. Male SD rats aged 8 weeks were randomly allocated to six groups: Control group, NC + Con group that SD rats treated with the empty lentivirus, NC + FTO-OE group that SD rats treated with the lentiviral vector carrying an over-expressed FTO gene, T2DM rats, T2DM + Con group that T2DM rats treated with the empty lentivirus, and T2DM + FTO-KD group that T2DM rats treated with the lentivirus carrying an siRNA targeting FTO. Two weeks after injection, the expression of FTO, TNIP1, caspase-1, p-eNOS/eNOS, as well as the ratio of pyroptotic endothelial cells in the penile corpus cavernosum, was evaluated.</p><p><strong>Outcomes: </strong>Upregulation of FTO in the penile corpus cavernosum of T2DM rats promoted m6A demethylation of TNIP1 mRNA, decreased TNIP1 expression, and enhanced the NFκB/caspase-1 pathway, thereby increasing endothelial pyroptosis and reducing ED.</p><p><strong>Results: </strong>Compared with the NC group, the T2DM group exhibited significantly increased FTO expression, whereas global RNA m6A methylation, ICPmax/MAP, p-eNOS/eNOS, and NO levels were significantly decreased (P < .05). Compared with the T2DM group, the T2DM + FTO-KD group showed markedly higher TNIP1 levels, p-eNOS/eNOS, and ICPmax/MAP, accompanied by reduced expression of FTO, NFκB, caspase-1, and significantly lower pyroptotic endothelial cells (P < .05).</p><p><strong>Clinical implications: </strong>Targeting FTO-mediated TNIP1 m6A demethylation may offer a therapeutic strategy for T2DM-associated ED.</p><p><strong>Strengths and limitations: </strong>Other m6A regulators potentially involved in this process were not assessed.</p><p><strong>Conclusion: </strong>In T2DM, upregulated FTO promoted m6A demethylation of TNIP1 mRNA, downregulated TNIP1 expression, enhanced NFκB/caspase-1 signaling, and increased endothelial cell pyroptosis in the penile corpus cavernosum, thereby contributing to ED.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and tolerability of a novel implantable neurostimulator to improve erectile function: a pilot study in patients with spinal cord injury.","authors":"Sidney Glina, Leonardo Seligra-Lopes, Pedro Fernandes Lessa, Renan Trevisan Jost, Felipe Placco Araújo Glina, Caio Cesar Cintra, Oseas de Castro Neves Neto, Roberto Vaz Juliano, Luis Augusto Seabra Rios, Rodrigo A Fraga-Silva, Mikael Sturny, Nikolaos Stergiopulos, Arthur L Burnett","doi":"10.1093/jsxmed/qdag111","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag111","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Postorgasmic illness syndrome (POIS) in two patients responding to sertraline: a case report.","authors":"","doi":"10.1093/jsxmed/qdag140","DOIUrl":"10.1093/jsxmed/qdag140","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of sexual communication and attitudes in adults.","authors":"Josías Guzmán","doi":"10.1093/jsxmed/qdag099","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag099","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"The impact of elective adult circumcision for religious reasons on sexual function and satisfaction: a pilot study\".","authors":"Kevin Barrett","doi":"10.1093/jsxmed/qdag092","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag092","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}