Journal of Sexual Medicine最新文献

{"title":"Effect of 100 mg of testosterone cypionate in trans men with erythrocytosis: a randomized controlled pilot study.","authors":"Sérgio Henrique Pires Okano, Silvio Antônio Franceschini, Débora Aiesha Leite Cantelli, Ana Carolina Japur de Sá Rosa E Silva, Rui Alberto Ferriani, Luiz Gustavo Oliveira Brito, Lúcia Alves da Silva Lara","doi":"10.1093/jsxmed/qdaf263","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf263","url":null,"abstract":"<p><strong>Background: </strong>Testosterone cypionate is commonly administered at 200 mg every 2 weeks to facilitate masculinization in transgender men. However, this regimen may increase hematocrit (Hct) by up to 6.9%.</p><p><strong>Aim: </strong>To compare the effects of biweekly intramuscular administration of 100 mg testosterone cypionate versus testosterone suspension on hematologic parameters and testosterone concentration in transgender men with erythrocytosis.</p><p><strong>Methods: </strong>A randomized, controlled pilot clinical trial which enrolled transgender men aged 18-40 years with secondary erythrocytosis (Hct ≥ 50%) related to testosterone therapy. Exclusion criteria included current contraceptive use, severe psychiatric disorders, or Hct ≥ 55%. Participants received either biweekly supervised intramuscular injections of 100 mg testosterone cypionate for 3 months or underwent complete testosterone withdrawal.</p><p><strong>Main outcome measures: </strong>Hct, hemoglobin, and total testosterone concentrations.</p><p><strong>Results: </strong>Forty-three participants completed the study protocol. Greater reductions in Hct were observed in the control group (-3.5 ± 0.5% vs -0.8 ± 0.5%; P < .001), as well as in hemoglobin (-0.97 ± 0.16 g/dL vs -0.17 ± 0.17 g/dL; P = .002) and testosterone (-510.16 ± 120.42 ng/dL vs 75.72 ± 123.26 ng/dL; P = .002). However, this difference was significant only when a >1.0 percentage point reduction in Hct was expected. In the intervention group, reductions in diastolic blood pressure (117.05 ± 13.72 mmHg vs 113.19 ± 12.77 mmHg; P = .040), body weight (70.59 ± 15.16 kg vs 69.34 ± 14.44 kg; P = .003), and HADS anxiety scores (7.90 ± 4.37 vs 5.19 ± 4.17; P = 0.001) were also observed. No serious adverse events were reported.</p><p><strong>Clinical implications: </strong>Dose reduction, although less effective than complete testosterone suspension in lowering Hct, suggests a potentially valuable strategy for patients with moderately elevated Hct levels. In this group, Hct levels remained stable and within acceptable limits, while therapeutic serum testosterone concentrations were preserved.</p><p><strong>Strengths and limitations: </strong>To our knowledge, this is the first clinical trial to assess the impact of testosterone dose fractionation in transgender men, with close monitoring and follow-up in both intervention arms. Among the study's limitations are the absence of a sham control group and the use of a convenience sample recruited from a single specialized center.</p><p><strong>Conclusion: </strong>Testosterone suspension appears to be more effective in reducing Hct than dose reduction when a decrease greater than 1% in Hct is desired. Nonetheless, dose reduction preserved therapeutic testosterone levels while offering additional benefits in blood pressure, anxiety, and body weight.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of a cohort construction: Perspective on \"A European network for the investigation of gender incongruence in adolescents\".","authors":"Sérgio Henrique Pires Okano","doi":"10.1093/jsxmed/qdaf269","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf269","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framing the overlooked: Perspective on \"Psychosexological correlates of 372 women with vulvodynia, overactive pelvic floor, postcoital cystitis, and interstitial cystitis\".","authors":"Ali Furkan Batur, Elif Balevi Batur, Murat Gül","doi":"10.1093/jsxmed/qdaf273","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf273","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging gaps in transgender and gender diverse youth care: Perspective on \"A European network for the investigation of gender incongruence in adolescents\".","authors":"Rezvan Shekarchi","doi":"10.1093/jsxmed/qdaf272","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf272","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Members in leading organizations for sexual medicine face continued ambiguity and uncertainty regarding the relationship between Peyronie's disease and intracavernosal injections: A survey of members of SMSNA, SUPS, and GURS.","authors":"Brent D Nosé, Jordan R Foreman, Kiran Sury, Martin S Gross, Aaron C Lentz","doi":"10.1093/jsxmed/qdaf261","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf261","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Words matter: patient experiences while seeking diagnosis for chronic pelvic, vulvar, and vaginal pain conditions.","authors":"Jennifer P Romanello, Jetashree Kumaravel, Azra Sadikovic, Rachel S Rubin, Janeane Anderson","doi":"10.1093/jsxmed/qdaf188","DOIUrl":"10.1093/jsxmed/qdaf188","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1796-1798"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of TENACIO pump versus momentary squeeze pump efficiency using surface electromyography.","authors":"Justin Lee, Daniel Schoenfeld, Andrew T Gabrielson, Benjamin Dropkin, Allen Morey, Gregory Joice","doi":"10.1093/jsxmed/qdaf176","DOIUrl":"10.1093/jsxmed/qdaf176","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1880-1881"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Evidence-Based Management Guidelines on Peyronie's Disease.","authors":"","doi":"10.1093/jsxmed/qdaf219","DOIUrl":"10.1093/jsxmed/qdaf219","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1910"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher sexual frequency correlated with lowered PSA complex levels in U.S. men aged 40-59 and without prostate conditions: a nationwide cross-sectional study.","authors":"Zhechun Wu, Mingxi Yao, Yuqing Li, Zhizhi Wang, Wei Wang","doi":"10.1093/jsxmed/qdaf177","DOIUrl":"10.1093/jsxmed/qdaf177","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1788-1790"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When is low sexual function problematic for women? A systematic review of factors associated with distress about low sexual function.","authors":"Teagan Stotz, Jessica L Mackelprang, Astrid Harkin, Danielle Hunt, Simone Buzwell","doi":"10.1093/jsxmed/qdaf192","DOIUrl":"10.1093/jsxmed/qdaf192","url":null,"abstract":"<p><strong>Introduction: </strong>While many women experience low levels of sexual desire and arousal, difficulty orgasming, or pain during intercourse, relatively few report distress about their sexual functioning. Distress about low sexual function is necessary for a sexual dysfunction to be diagnosed. However, it is not clear why some women report distress while others do not.</p><p><strong>Objectives: </strong>The aim of the current study was to review systematically factors associated with distress about low sexual function among premenopausal women.</p><p><strong>Methods: </strong>Six databases (CINAHL, Psychology and Behavioural Sciences Collection, PubMed, Web of Science, PsycNET, Scopus) were searched on January 1, 2025. The quality of each study was evaluated using the Mixed Methods Appraisal Tool.</p><p><strong>Results: </strong>Nineteen studies met the inclusion criteria. Most samples consisted of women in a heterosexual relationship, and the majority of articles focused on sexual pain disorders. Factors associated with distress about low sexual function were grouped into four factors: sexual, psychological, relationship, and partner-related. Sexual distress was positively associated with severity of low sexual function, depressive, or anxiety symptoms, sexual dissatisfaction, poor relationship communication, low partner support, and partner's sexual distress and dissatisfaction.</p><p><strong>Conclusion: </strong>Sexual satisfaction and relational factors influence whether women experience low sexual function as problematic. However, more research is needed to investigate sexual distress among women who are not in a heterosexual relationship, and those reporting low sexual functioning in domains of sexual arousal, desire, and orgasm.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1827-1838"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}