Journal of Sexual Medicine最新文献

{"title":"Dual-action intranasal oxytocin enhances both male sexual performance and fertility in rats.","authors":"Chica Enomoto, Takumi Oti, Takahiro Yamanaka, Masayuki Shimada, Hirotaka Sakamoto","doi":"10.1093/jsxmed/qdaf228","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf228","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness and sexual satisfaction in postpartum couples: the mediating role of sexual function and sexual distress.","authors":"Sara M Saavedra, Inês M Tavares","doi":"10.1093/jsxmed/qdaf234","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf234","url":null,"abstract":"<p><strong>Background: </strong>The transition to parenthood often brings challenges to couples' sexual satisfaction, underscoring the need to identify protective factors that can mitigate these effects. Mindfulness has emerged as a potential targetable factor, but its specific mechanisms of action in postpartum couples remain unclear.</p><p><strong>Aim: </strong>This study tested the association between mindfulness and postpartum sexual satisfaction among new parent couples and examined whether this relationship was mediated by individuals' and partners' sexual function and sexual distress.</p><p><strong>Methods: </strong>Using a dyadic approach, we sampled 161 mixed-sex/gender first-time parent couples at 3 months postpartum. Couples completed validated measures of trait mindfulness, sexual satisfaction, sexual function, and sexual distress. Hypotheses were tested using mediation analyses guided by the actor-partner interdependence model.</p><p><strong>Outcomes: </strong>Individual and partner self-reported sexual satisfaction, sexual function, and sexual distress.</p><p><strong>Results: </strong>For men, greater trait mindfulness was associated with higher sexual satisfaction through improved sexual function. For women, greater trait mindfulness was linked to higher sexual satisfaction through reduced sexual distress. Actor effects (ie, an individual's mindfulness influencing their own sexual satisfaction) were significant, while partner effects (ie, one partner's mindfulness influencing the other's sexual satisfaction) were not observed.</p><p><strong>Clinical implications: </strong>These findings suggest that trait mindfulness may play a role in enhancing sexual satisfaction during the postpartum period, but through distinct mechanisms for men and women. Specifically, mindfulness appears to improve sexual satisfaction in men through sexual function, and in women through reduced sexual distress. These gender-specific patterns could inform the development of mindfulness-based interventions tailored to the unique challenges faced by men and women during this transitional phase.</p><p><strong>Strengths and limitations: </strong>The strengths include the large, dyadic sample and focus on the early postpartum period. The limitations include the cross-sectional design, which prevents conclusions about causality or long-term effects.</p><p><strong>Conclusion: </strong>This study highlights trait mindfulness as a key factor in postpartum sexual satisfaction, operating through sexual function in men and sexual distress in women, and underscores the need for further research on mindfulness-based interventions for couples.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of discrimination among BDSM and kink practitioners.","authors":"Manuel Catalán Águila, Inmaculada Fernández Agis, Jenna Marie Strizzi","doi":"10.1093/jsxmed/qdaf235","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf235","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment of the top 60 drugs for drug-related sexual dysfunction: a disproportion analysis from the Food and Drug Administration adverse event reporting system.","authors":"Lihua Wu, Mei Rao, Yangyi Chen, Huiying Wang","doi":"10.1093/jsxmed/qdaf227","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf227","url":null,"abstract":"<p><strong>Background: </strong>Although several drugs are associated with sexual dysfunction (SD), the SD-related risks of most drugs are not yet known.</p><p><strong>Aim: </strong>Our study will evaluate the risk signals of adverse drug event (ADE) that may be associated with SD in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to promote rational clinical drug use.</p><p><strong>Methods: </strong>SD-related drugs were examined using reporting odds ratio (ROR), proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker. The top 60 drugs were identified based on the reported frequency and signal intensity. Univariate and multivariate regression analyses were used to explore the risk factors for drug-related SD.</p><p><strong>Outcomes: </strong>The signal intensity between drug and SD was evaluated by signal detection method.</p><p><strong>Results: </strong>In total, 79 022 SD-related ADEs were identified, including 61 722 patients. The patients included 40 273 males (65.25%) and 17 777 females (28.80%), with more adults aged 18-65 years (52.29%). The three drugs with the highest ROR risk signals were finasteride (ROR [95% CI]: 212.3 [204.74-220.13]), dutasteride (ROR [95% CI]: 29.11 [26.84-31.56]), and silodosin (ROR [95% CI]: 21.81 [17.94-26.52]). Multivariate regression analysis showed that male, age 31-45 years, and 34 drugs including finasteride were risk factors for drug-related SD.</p><p><strong>Clinical implications: </strong>Our findings emphasize the importance of the effects of drugs on SD and provide a reference point for further research on the pathogenesis of drug-related SD.</p><p><strong>Strengths and limitations: </strong>Our study is the first to explore the potential association between medications and SD ADE using the FAERS database. However, as this study was a retrospective observational pharmacovigilance study, the causality could not be further assessed.</p><p><strong>Conclusion: </strong>We identified 34 drugs that may be related to SD, with a predominance in the nervous system. This finding suggests that clinicians should be aware of the risk of SD associated with these drugs.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic differences in non-plaque tissues of men with Peyronie's disease.","authors":"Jessica Schardein, Jordan Moore, Brendan Olson, Sidney Kaufmann, Masaya Jimbo, Kelli Gross, Seth Parks, Tim Jenkins, Alexander W Pastuszak, James M Hotaling, Michael B Christensen","doi":"10.1093/jsxmed/qdaf233","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf233","url":null,"abstract":"<p><strong>Background: </strong>Peyronie's disease (PD) is a fibrosing disorder with a hereditary predisposition that can have significant impacts on quality of life.</p><p><strong>Aim: </strong>Our pilot study's objective was to determine if disease penetrance is correlated with epigenetic variations in non-plaque tissue, as compared with tissue from men with erectile dysfunction (ED), as indicated by DNA methylation.</p><p><strong>Methods: </strong>Tunica albuginea samples were collected from non-plaque tissue during penile prosthesis placement for men with ED with and without PD, with ED-only samples serving as controls. DNA methylation analyses were performed on homogenized penile tissue samples via an Illumina Human MethylationEPIC BeadChip v2 array. Using the minfi package in R, beta values were produced for all 936 990 CpG sites for each sample and subset-quantile within array normalization (SWAN) normalization was applied. Differentially methylated regions (DMRs) were found via USeq with a threshold Wilcoxon FDR score of 40.</p><p><strong>Outcomes: </strong>The primary outcome of the study was the prevalence and significance of DMRs between samples and controls.</p><p><strong>Results: </strong>A total of 10 ED + PD and 12 ED-only samples were successfully processed for subsequent epigenetic analyses. Thirty-six DMRs with 60 total region-gene associations and five implicated biological processes were identified, including anterior/posterior pattern specification, chordate embryonic development, embryo development (ending in birth or egg hatching), somitogenesis, and pattern specification process. Each of the implicated biological processes are essential components of the human body's developmental biology and the specific region-gene associations suggest pathogenesis may be an early embryonic development.</p><p><strong>Clinical implications: </strong>The identification of these epigenetic changes in non-plaque tissue suggests a systemic process related to PD that is not isolated to plaque tissue and provides further insight into PD pathogenesis.</p><p><strong>Strengths and limitations: </strong>The strength of this pilot study is that it evaluated methylation changes between ED + PD and ED-only individuals using new and updated array analyses. This pilot study is limited due to a cross-sectional design that only examines differential methylation in non-plaque tissues.</p><p><strong>Conclusion: </strong>Identification of epigenetic differences in non-plaque tissue in men with and without PD suggests systemic changes and provides further insight into the pathogenesis of PD.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-nucleus RNA sequencing reveals cellular and molecular signatures in the prefrontal cortex of a hypoactive sexual desire disorder rat model.","authors":"Mengyue Chen, Lingfang Guan, Lu Zhu, Bing Song, Chao Wang, Xiaojin He, Ping Zhou, Guanjian Li","doi":"10.1093/jsxmed/qdaf138","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf138","url":null,"abstract":"<p><strong>Background: </strong>Hypoactive sexual desire disorder (HSDD), a prevalent condition affecting sexual health in women, is induced by imbalanced neurobiological regulation of excitatory and inhibitory pathways associated with sexual response. The prefrontal cortex (PFC) is a key region in the sexual desire response pathway. Nevertheless, the cellular dynamics and molecular mechanisms driving the pathophysiology of HSDD remain unclear, limiting targeted therapeutic development.</p><p><strong>Aim: </strong>To explore the cellular and molecular mechanisms of HSDD using a female rat model.</p><p><strong>Methods: </strong>We established a translational HSDD model using female Sprague-Dawley rats with low sexual desire. Subsequently, single-nucleus RNA sequencing (snRNA-seq) and multimodal bioinformatics analyses were used to comprehensively characterize cellular diversity and transcriptional signatures in the PFC.</p><p><strong>Outcomes: </strong>Primary: neuronal/glial composition; secondary: disease-relevant pathway dysregulation.</p><p><strong>Results: </strong>SnRNA-seq profiling revealed altered PFC cell composition in rats with low sexual desire (LSD), with increased proportions of inhibitory neuron subtypes (Inh1-3) and microglia, concomitant reductions in excitatory neuron populations (Ex1 and Ex3), and disrupted oligodendrocyte precursor cell (OPC) maturation. Transcriptomic analysis revealed 506 differentially expressed genes (DEGs), of which 91.3% were downregulated in the LSD group. Enrichment analyses linked the DEGs to mitochondrial dysfunction, lysosomal function, and neurodegenerative disease-associated pathways.</p><p><strong>Clinical implications: </strong>These preliminary findings potentially advance our understanding of HSDD neurobiology, and identify testable targets for therapeutic intervention.</p><p><strong>Strengths & limitations: </strong>The high-throughput analysis offered detailed information, but the small sample size and potential confounding factors in phenotype classification were limitations.</p><p><strong>Conclusions: </strong>We have established a stable translational model of HSDD through rigorous screening and validation, demonstrating specific molecular and cellular alterations in the PFC of model rats characterized by: (1) excitatory-inhibitory neuronal imbalance, (2) microglial activation indicative of neuroimmune dysregulation, and (3) OPC maturation deficits.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared voices online: a mixed-methods analysis of patient narratives on gender-affirming facial surgery.","authors":"Antoinette T Nguyen, Sophia Ellis, Rohan Chanda, Jonathan Leckenby, Clinton Morrison","doi":"10.1093/jsxmed/qdaf226","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf226","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intracavernosal incobotulinumtoxinA (Xeomin) as add-on therapy to sildenafil for the treatment of erectile dysfunction insufficiently responsive to phosphodiesterase type 5 inhibitors.","authors":"Francois Giuliano, Anne-Charlotte Denormandie, Francois-Xavier Madec, Damien Carnicelli, Jean-Pierre Graziana, Stéphane Droupy, Francois Marcelli, Malamine Gassama, Lamiae Grimaldi","doi":"10.1093/jsxmed/qdaf225","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf225","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Studies suggest intracavernosal botulinum toxin A (BTX/A) could improve difficult-to-treat erectile dysfunction (ED) ie with an insufficient response to phosphodiesterase type 5 inhibitors (PDE5-Is).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate efficacy and safety of intracavernosal injection (ICI) of BTX/A combined with sildenafil 100 mg on demand in patients with ED and insufficient response to PDE5-Is.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Double-blind, placebo-controlled, multicenter, randomized phase 2 trial to investigate the efficacy and safety of bilateral 0.5 ml ICIs of incobotulinumtoxinA 50 U or placebo, both combined with sildenafil 100 mg on demand in men with ED and insufficient response to sildenafil 100 mg on demand. The inclusion criteria were International Index of Erectile Function-Erectile Function (IIEF-EF) domain score &lt; 17 and &gt;50% of attempts at sexual intercourse unsuccessful during a 4-week open-label run-in phase with sildenafil 100 mg on demand.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Mean change in IIEF-EF score and the proportion of \"Yes\" responses to Sexual Encounter Profile (SEP)-Q2 (ability to penetrate) and SEP-Q3 (ability to maintain an erection for successful intercourse) at 3 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Out of 226 patients screened, 165 patients were randomized (mean age: 60.1 years, mean IIEF-EF on sildenafil 100 mg: 11.1). Intention-to-treat (ITT) analysis showed no significant improvement in IIEF-EF score with incobotulinumtoxinA 100 U combined with sildenafil 100 mg at 3 months. IncobotulinumtoxinA 100 U improved penetration (SEP-Q2) and erection maintenance (SEP-Q3), but not significantly. These results were confirmed by the complete-case and per-protocol analyses. Adjusted analysis for 100% adherence to sildenafil 100 mg showed a significant interaction effect (P = .032), suggesting greater IIEF-EF improvement in fully compliant patients. The safety profile was positive.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;IncobotulinumtoxinA 100 U combined with sildenafil 100 mg on demand is safe; however, there is yet no robust evidence to support its use to treat ED.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Main strengths include the double-blind, placebo-controlled design, which was preceded by an open-label run-in phase, a 3-month follow-up, the use of ITT analysis and meaningful outcome measures. Limitations include no adherence to sildenafil (28%), inconsistent clamping at the penile crus post-incobotulinumtoxinA injection, and an underpowered sample size due to an overestimated treatment effect.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Despite negative ITT effectiveness results, this study demonstrated the safety of intracavernosal BTX/A. The results raise hypotheses regarding its potential role in combination with PDE5-Is, warranting further investigation. Future trials should refine patient selection and injection technique, assess dose-response effects, and improve pro","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile metastasis from rectal carcinoma misdiagnosed as Peyronie's disease: a rare presentation.","authors":"Or Schubert, Maria C Sighinolfi, Francesco Pierconti, Gaetano Gulino, Pierluigi Russo, Antonio Silvestri, Bernardo Rocco","doi":"10.1093/jsxmed/qdaf222","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf222","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Outdated and offensive\": trans and nonbinary individuals' responses to clinical scales of gender dysphoria.","authors":"Zakary A Clements PhD, Lex Pulice-Farrow PhD, M Paz Galupo PhD","doi":"10.1093/jsxmed/qdaf231","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf231","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}