Journal of Sexual Medicine最新文献

{"title":"Propofol-induced priapism: a rare occurrence with severe outcomes.","authors":"Carolina Baz, Helen Prevas, Christopher Graziano, David W McDermott","doi":"10.1093/jsxmed/qdaf195","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf195","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort.","authors":"Samantha Schildroth, Julia Bond, Amelia K Wesselink, Martha R Koenig, Antonia M Calafat, Julianne Cook Botelho, Jasmine Abrams, Lauren A Wise","doi":"10.1093/jsxmed/qdaf205","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf205","url":null,"abstract":"<p><strong>Background: </strong>Phthalates are endocrine-disrupting chemicals that can dysregulate hormonal systems supporting female sexual function (eg, estrogen interference). Female sexual function is important for positive sexual expression, fertility, and well-being but remains understudied in the context of environmental toxicants to which females are ubiquitously exposed. Identifying environmental determinants of female sexual dysfunction can inform exposure-reduction strategies and clinical practice to improve sexual health.</p><p><strong>Aim: </strong>We investigated associations between phthalate exposure and sexual function in a cohort of North American females.</p><p><strong>Methods: </strong>We leveraged cross-sectional data from a subset of 21-45-year-old females trying to conceive enrolled in Pregnancy Study Online (n = 347) to assess associations between phthalate and phthalate alternative exposure and sexual function, measured on a modified version of the Female Sexual Function Index-6 (FSFI-6). We summed FSFI-6 responses (range = 2-30); lower scores reflected poorer function. We measured urinary concentrations of 18 phthalate and alternative metabolites using online solid phase extraction coupled with high-performance liquid chromatography isotope dilution tandem mass spectrometry. Given that the biomarkers were nonlinearly associated with FSFI-6 scores, we categorized creatinine-corrected biomarker concentrations in tertiles. We used multivariable linear regression to estimate mean differences (β) with 95% confidence intervals (CIs) in FSFI-6 scores per tertile increase in biomarker concentrations, adjusting for hypothesized confounders. In secondary analyses, we considered individual FSFI-6 items (range = 1-5) as outcome variables.</p><p><strong>Outcomes: </strong>Female sexual function measured on the FSFI-6.</p><p><strong>Results: </strong>Most biomarkers were not associated with FSFI-6 scores. Mono-n-butyl phthalate concentrations were weakly and non-monotonically associated with lower summed FSFI-6 scores (β = -0.8, 95% CI = -1.8, 0.2) and orgasm scores (β = -0.3, 95% CI = -0.7, 0.1) at the second (vs first) tertile, reflecting poorer sexual function. Mono-2-ethyl-5-carboxypentyl terephthalate concentrations were weakly associated with poorer scores for orgasm, while other biomarkers (notably, mono-carboxyisononyl phthalate) were associated with higher summed FSFI-6 and FSFI-6 item scores.</p><p><strong>Clinical implications: </strong>Exposure to phthalates should be considered in clinical settings, particularly for females experiencing issues with sexual function.</p><p><strong>Strengths and limitations: </strong>This study represents one of the first to assess associations of phthalate exposure and female sexual function, and we investigated associations in an established cohort with a validated measure of sexual function. We were limited by our sample size and cross-sectional study design.</p><p><strong>Conclusion: </s","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing transference risk to prepubertal children among candidates for transdermal testosterone therapy.","authors":"Marcelo Mass Lindenbaum, Samantha Thorogood, Luis F Novaes, Nicole Benfante, John P Mulhall, Jose M Flores","doi":"10.1093/jsxmed/qdaf193","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf193","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When is low sexual function problematic for women? A systematic review of factors associated with distress about low sexual function.","authors":"Teagan Stotz, Jessica L Mackelprang, Astrid Harkin, Danielle Hunt, Simone Buzwell","doi":"10.1093/jsxmed/qdaf192","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf192","url":null,"abstract":"<p><strong>Introduction: </strong>While many women experience low levels of sexual desire and arousal, difficulty orgasming, or pain during intercourse, relatively few report distress about their sexual functioning. Distress about low sexual function is necessary for a sexual dysfunction to be diagnosed. However, it is not clear why some women report distress while others do not.</p><p><strong>Objectives: </strong>The aim of the current study was to review systematically factors associated with distress about low sexual function among premenopausal women.</p><p><strong>Methods: </strong>Six databases (CINAHL, Psychology and Behavioural Sciences Collection, PubMed, Web of Science, PsycNET, Scopus) were searched on January 1, 2025. The quality of each study was evaluated using the Mixed Methods Appraisal Tool.</p><p><strong>Results: </strong>Nineteen studies met the inclusion criteria. Most samples consisted of women in a heterosexual relationship, and the majority of articles focused on sexual pain disorders. Factors associated with distress about low sexual function were grouped into four factors: sexual, psychological, relationship, and partner-related. Sexual distress was positively associated with severity of low sexual function, depressive, or anxiety symptoms, sexual dissatisfaction, poor relationship communication, low partner support, and partner's sexual distress and dissatisfaction.</p><p><strong>Conclusion: </strong>Sexual satisfaction and relational factors influence whether women experience low sexual function as problematic. However, more research is needed to investigate sexual distress among women who are not in a heterosexual relationship, and those reporting low sexual functioning in domains of sexual arousal, desire, and orgasm.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular grafting combined for length gain in men after penile implant surgery.","authors":"Michael West, Jose M Flores, John P Mulhall","doi":"10.1093/jsxmed/qdaf190","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf190","url":null,"abstract":"<p><strong>Introduction: </strong>Acquired penile shortening has multiple possible causes, including Peyronie's disease, penile prosthesis (PP) removal, trauma, radical prostatectomy, and long-standing erectile dysfunction. If severe, it can preclude the ability to have intercourse. Multiple surgical techniques aimed at enhancing penile length have been described. Herein, we describe a circular grafting technique for penile lengthening in men with debilitating penile length loss.</p><p><strong>Aim: </strong>To describe the indications, technique, outcomes, and complications associated with circular grafting with PP insertion.</p><p><strong>Methods: </strong>We describe our preferred method for performing circular grafting with PP insertion.</p><p><strong>Main outcome measure: </strong>Penile length gain achieved after circular grafting.</p><p><strong>Results: </strong>Average penile length gain after circular grafting is 2.5 cm in our practice. This is similar to the length gain associated with other similar procedures.</p><p><strong>Conclusion: </strong>Circular grafting is a viable option to augment penile length in men with penile length loss precluding intercourse. Possible complications include changes in sensation, tissue necrosis, infection, and PP malfunction.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of device-assisted circumcision on sexual quality of life in adult males: a systematic review.","authors":"Michalina Grudzińska, Jakub Gondek, Mateusz Czajkowski, Marcin Matuszewski","doi":"10.1093/jsxmed/qdaf191","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf191","url":null,"abstract":"<p><strong>Introduction: </strong>Device-assisted circumcision has emerged as an alternative to traditional surgical methods, offering improved safety, efficiency, and cosmetic outcomes. While its clinical benefits are documented, on analyzing the literature, no comprehensive synthesis of the impact of device-assisted circumcision on sexual quality of life in adult men, including erectile function, ejaculation control, and overall satisfaction, has been found.</p><p><strong>Objectives: </strong>To synthesize the present literature regarding the effects of device-assisted circumcision on sexual quality of life among adult male populations.</p><p><strong>Methods: </strong>A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines was conducted. A systematic search of PubMed, EMBASE, Google Scholar, SCOPUS, EBSCO HOST, and the Cochrane Library was performed up to December 2024. The inclusion criteria encompassed prospective and retrospective clinical trials, cohort, cross-sectional, or case control, enrolling male patients ≥ 18 years old, regardless of ethnicity, marital status, and country of origin, who underwent device-assisted circumcision. The Newcastle-Ottawa Scale and Effective Public Health Practice Project Quality Assessment Tool were utilized for risk of bias assessment.</p><p><strong>Results: </strong>Literature searches identified 1643 records; 8 articles met the inclusion criteria, including 965 patients available for analysis. This cohort included 965 individuals circumcised using circumcision devices (PrePex [336]; ShangRing [297]; Alisklamp [267]; a novel disposable circumcision stitching instrument [51], and the adult circumcision template [14]). The mean age of participants ranged between 21.2 and 34.2 years. The circumcision devices either positively influence or maintain sexual satisfaction and functioning in males. Furthermore, the circumcision procedure has minimal adverse effects on erectile function, with some evidence suggesting potential improvement in the long term. Conflicting results were observed regarding sexual satisfaction and prolonged intercourse, with some studies reporting increased satisfaction and extended intercourse duration, while others found no significant changes in these aspects.</p><p><strong>Conclusion: </strong>The device-assisted circumcision demonstrates a positive influence on or maintains sexual quality of life in adult males, resulting in enhancements in erection quality, ejaculation control, duration of intercourse, and overall male satisfaction. The findings support its viability as a safe and efficacious alternative to traditional methods.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new mini-invasive surgical treatment for Peyronie's disease: mechanically processed lipoaspirates as regenerative therapy.","authors":"Elisa Berdondini, Maiolino Giuseppe, Andrea Margara, Patrizio Rigatti, Salvatore Voce, Giulio Reale, Carlo Saltutti, Marco Maroccia, Juan Ignacio Martínez-Salamanca, Mauro Gacci, Pier Andrea Della Camera, Lorenzo Tosco, Ahmed Eissa, Angelo Trivisonno, Nicola Mondaini, Carlo Bettocchi, Mauro Silvani","doi":"10.1093/jsxmed/qdaf196","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf196","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the prevalence of premature ejaculation as a three-dimensional construct of sexual dysfunction-a systematic review.","authors":"Mariella Opolony, Martin Rettenberger, Peer Briken, Daniel Turner","doi":"10.1093/jsxmed/qdaf187","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf187","url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation is one of the most common types of sexual dysfunction among men. Frequently, a distinction was made between 4 premature ejaculation subtypes-lifelong, acquired, natural-variable, and subjective. Although somewhat outdated but still relevant in terms of etiological considerations, most researchers and clinicians in the past have summarized these subtypes under the terms psychogenic ejaculatory complaint (natural-variable and subjective premature ejaculation) and somatogenic impaired ejaculatory control (lifelong and acquired premature ejaculation). To date, there is no universally accepted subtype-specific therapy to treat premature ejaculation, as the exact etiology and prevalence of the individual premature ejaculation subtypes have not yet been sufficiently researched.</p><p><strong>Aim: </strong>The present systematic review aimed at examining the prevalence of premature ejaculation within the general population, as well as the prevalence of the premature ejaculation subtypes and the influence on prevalence rates of the diagnostic criteria being used.</p><p><strong>Methods: </strong>A total of 79 prevalence studies with 158 prevalence estimates from 33 countries, which were published in English or German, were systematically reviewed and compared. Studies from 1986 to August 2024 were included.</p><p><strong>Results: </strong>In total, the identified studies included a total sample size of 319 468 participants. The prevalence rate of premature ejaculation (Mw = 14.19%, SD = 15.87%) was strongly dependent on the research definition used. In terms of prevalence, psychogenic ejaculatory complaint appeared to dominate over somatogenic impaired ejaculatory control both within the general population (Mw = 18.22%, SD = 16.10% vs. Mw = 9.97%, SD = 14.06%) and among individuals with premature ejaculation (lifelong premature ejaculation: Mw = 11.67%, SD = 2.70%; acquired premature ejaculation: Mw = 18.96%, SD = 2.20%; natural-variable premature ejaculation: Mw = 43.89%, SD = 10.55%; subjective premature ejaculation: Mw = 24.79%, SD = 5.18%).</p><p><strong>Strengths and limitations: </strong>The main limitation of this review is the varying sample populations across studies. The heterogeneity of 158 premature ejaculation subtype-specific prevalence surveys from 79 studies prevented meta-analysis. A systematic review was chosen to use mean differences, allowing for continuous results and comparability. This design enabled the examination of several studies to identify population-based trends.</p><p><strong>Conclusion: </strong>Taking into account the review findings, it can be suggested that, in terms of a need-based treatment, the definition of premature ejaculation should be expanded to include the various forms and subtypes of premature ejaculation.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of simenafil in men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel group, phase 3 trial.","authors":"Yuzhuo Yang, Xiansheng Zhang, Tao Jiang, Lianming Zhao, Fubiao Li, Wenliang Yao, Junhong Deng, Xiangsheng Zhang, Jin Yang, Zhigang Ji, Zhigang Tong, Yun Chen, Zhen Wang, Jiaxiang Juan, Huaqing Duan, Hui Jiang","doi":"10.1093/jsxmed/qdaf109","DOIUrl":"10.1093/jsxmed/qdaf109","url":null,"abstract":"<p><strong>Background: </strong>Simenafil, a potent and highly selective oral phosphodiesterase type 5 (PDE5) inhibitor, is currently under investigation for erectile dysfunction (ED) treatment.</p><p><strong>Aims: </strong>To evaluate the efficacy and safety of simenafil for ED treatment.</p><p><strong>Methods: </strong>This was a multicenter, randomized, double-blind, placebo-controlled, parallel group, phase 3 study in men aged 18-75 years with a history of ED of 6 months or more. The subjects were randomized in a ratio of 1:1:1:1 to on-demand receive fixed-dose either placebo or simenafil (2.5 mg, 5 mg or 10 mg) for 12 weeks.</p><p><strong>Outcomes: </strong>Primary efficacy endpoints were the least square mean (LSM) changes from baseline to week 12 in the erectile function (EF) domain of the International Index of Erectile Function (IIEF), percentages of \"yes\" responses to sexual encounter profile (SEP) diary question 2 (SEP Q2: Were you able to insert your penis into your partner's vagina?) and question 3 (SEP Q3: Did your erection last long enough for you to have successful intercourse?).</p><p><strong>Results: </strong>A total of 765 patients were randomized and 92.3% completed the study. The mean age of subjects was 41.3 years and 81.6% had moderate to severe ED (mean overall International Index of Erectile Function-Erectile Function (IIEF-EF) domain score 13.4). After 12 weeks of treatment, doses of 2.5, 5, and 10 mg of simenafil exhibited substantial increases than placebo in IIEF-EF score (12.3, 12.3, 12.7 vs. 9.6), the percentages of \"yes\" responses to SEP Q2 (40.58%, 42.43%, 43.98% vs. 32.05%), and SEP Q3 (61.91%, 63.70%, 65.19% vs. 46.70%) (all P < .001). Adverse drug reactions (ADRs) occurred in 36.2% of patients who received simenafil (32.6% in simenafil 5 mg group, the clinically recommended dose) and in 30.9% of those who received placebo. The most common (≥2%) ADRs were dizziness, headache, flushing, nasal congestion, and dry mouth, and most were mild or moderate. Furthermore, abnormal vision (PDE6 related) and myalgia (PDE11 related) did not occur in patients who received simenafil.</p><p><strong>Clinical implications: </strong>Simenafil is highly effective in all 3 dose groups and has a low effective dose and good safety profile, providing a novel, favorable treatment option for patients with ED.</p><p><strong>Strengths and limitations: </strong>The efficacy and safety evaluation of simenafil in difficult-to-treat patients with ED, ED patients with other concomitant diseases, and other ethnic populations was not performed.</p><p><strong>Conclusion: </strong>Simenafil is an effective and well-tolerated therapy for patients with ED.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1430-1439"},"PeriodicalIF":3.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of female and male İnfertility on men's depression, anxiety, sexual function, self-esteem, and quality of life: a prospective cross-sectional study from Turkiye.","authors":"Tuncay Toprak, Deniz Kulaksiz, Muhsin Balaban, Basar Ayribas, Asgar Garayev, Sule Yildirim Kopuk, Recep B Degirmentepe, Mehmet O Ozgur, Eda Ozcan, Ahmet Guzel, Ismail Baglar, Mehmet Yilmaz","doi":"10.1093/jsxmed/qdaf156","DOIUrl":"10.1093/jsxmed/qdaf156","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1525-1527"},"PeriodicalIF":3.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}