Journal of Sexual Medicine最新文献

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Testosterone, but not estradiol, dictates the expression of conditioned place preference for sexual behavior in male rats. 睾酮,而不是雌二醇,决定了雄性大鼠性行为的条件位置偏好的表达。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-11 DOI: 10.1093/jsxmed/qdaf082
Wayne R Hawley, Dana L Battershell, Brooke M Edwards, Kara L Shoemaker, Brooke E Lovell, Jenna N Bowman, Emma A Kraus
{"title":"Testosterone, but not estradiol, dictates the expression of conditioned place preference for sexual behavior in male rats.","authors":"Wayne R Hawley, Dana L Battershell, Brooke M Edwards, Kara L Shoemaker, Brooke E Lovell, Jenna N Bowman, Emma A Kraus","doi":"10.1093/jsxmed/qdaf082","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf082","url":null,"abstract":"<p><strong>Background: </strong>Although treatment with testosterone, or in some cases estradiol, reverses deficits in sexual motivation induced by the suppression of gonadal hormone signaling, the effects of testosterone or estradiol treatment on the expression of sexual reward remain to be determined.</p><p><strong>Aim: </strong>The aims of the study were to (1) determine if testosterone was critical for the expression of conditioned place preference (CPP) induced by sexual activity (ie, expression of sexual reward) and (2) if the effects of testosterone treatment on the expression of sexual reward could be mimicked by treatment with estradiol alone.</p><p><strong>Outcomes: </strong>The percentage of time spent in the chamber of a CPP apparatus associated with sexual activity was indicative of the expression of sexual reward, while the relative weights of the seminal vesicles and changes in body weight were analyzed to characterize androgen and estrogen activity, respectively.</p><p><strong>Methods: </strong>All sexually experienced Long-Evans male rats were first treated with a long-acting gonadotropin-releasing hormone receptor antagonist following their final conditioning trial, in which they learned to associate one end chamber of a 3-chambered CPP apparatus with sexual activity. Males were then treated with oil or single doses of either testosterone or estradiol 96 and 48 h prior to their CPP test trials and removal of seminal vesicles.</p><p><strong>Results: </strong>Only males treated with testosterone expressed CPP induced by sexual activity. Additionally, testosterone-treated males spent a significantly greater percentage of time in the chamber of the CPP apparatus associated with sexual activity than estradiol-treated males, an effect that also tended to be the case when comparing testosterone to oil-treated males. Testosterone increased the relative weight of the seminal vesicles, and estradiol treatment resulted in weight loss.</p><p><strong>Clinical implications: </strong>Although testosterone treatment impacted the expression of sexual reward, the results also suggest that treatment with estradiol alone may have limited clinical utility for treating those who are hypogonadal or undergoing androgen deprivation therapies, as the hormone did not mimic the effect of testosterone on the expression of sexual reward.</p><p><strong>Strengths and limitations: </strong>Strengths include the experimental nature of the study and novel investigation into the effect of testosterone and estradiol on the expression of sexual reward. Although the hormone was bioactive, one limitation of the study was the use of a single dose of estradiol.</p><p><strong>Conclusion: </strong>Treatment with testosterone, but not estradiol alone, regulates the expression of sexual reward in male rats.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Are patients undergoing intralesional collagenase Clostridium histolyticum injection therapy for Peyronie's disease compliant? A 7-year analysis from a tertiary care men's health center. 更正:局部注射胶原酶溶组织梭菌治疗Peyronie病的患者是否符合?来自三级保健男性健康中心的7年分析。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-09 DOI: 10.1093/jsxmed/qdaf152
{"title":"Correction to: Are patients undergoing intralesional collagenase Clostridium histolyticum injection therapy for Peyronie's disease compliant? A 7-year analysis from a tertiary care men's health center.","authors":"","doi":"10.1093/jsxmed/qdaf152","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf152","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical efficacy and safety of selective dorsal neurectomy/cryoablation for treatment of premature ejaculation: systematic review and meta-analysis. 选择性背神经切除术/冷冻消融治疗早泄的临床疗效和安全性:系统回顾和荟萃分析。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-09 DOI: 10.1093/jsxmed/qdaf140
Mehmet Gokhan Culha, Mustafa Erkoc, Caner Baran, Levent Ozcan
{"title":"Clinical efficacy and safety of selective dorsal neurectomy/cryoablation for treatment of premature ejaculation: systematic review and meta-analysis.","authors":"Mehmet Gokhan Culha, Mustafa Erkoc, Caner Baran, Levent Ozcan","doi":"10.1093/jsxmed/qdaf140","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf140","url":null,"abstract":"<p><strong>Introduction: </strong>Premature ejaculation (PE) is a prevalent sexual dysfunction with limited treatment options for some patients. Selective dorsal neurectomy/cryoablation (SDN/CA) has emerged as a potential treatment, aiming to desensitize the penis.</p><p><strong>Objectives: </strong>To assess the efficacy of SDN/CA on intravaginal ejaculation latency time (IELT), PE-related questionnaires, treatment satisfaction, erectile function, and adverse events in the treatment of PE.</p><p><strong>Method: </strong>A systematic review and meta-analysis were conducted, including randomized controlled trials, clinical trials, and prospective/retrospective studies. Databases such as Embase, PubMed, Cochrane, and Web of Science were searched. The Cochrane risk-of-bias tool and Risk of Bias in Non-randomized Studies of Interventions-I tool were used for quality assessment. IELT (sec), questionnaires (Premature Ejaculation Diagnostic Tool, Premature Ejaculation Profile, Sexual Satisfaction Score), erectile status (IIEF [International Index of Erectile Function]-5), and adverse events were evaluated. Comprehensive meta-analysis and R software were used for statistical analyses.</p><p><strong>Results: </strong>Seven studies (235 patients) were included. SDN/CA significantly improved IELT (mean difference: 147.47 sec, P < .05). Questionnaires showed improvements in sexual satisfaction and ejaculation control. No meaningful change was observed in the erectile function. The adverse event rate was 11.17%, with no significant difference between groups.</p><p><strong>Conclusion: </strong>SDN/CA is controversial as a treatment option for PE, affecting IELT and patient satisfaction. The heterogeneity of the included studies and short-term follow-up periods shed light on further research. However, further research into standard protocols and longer follow-ups is needed.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent premature ejaculation: exploring an understudied phenomenon. 间歇性早泄:探索一个未被充分研究的现象。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-08 DOI: 10.1093/jsxmed/qdaf113
David L Rowland, Stanley E Althof, Philippe Cote-Leger
{"title":"Intermittent premature ejaculation: exploring an understudied phenomenon.","authors":"David L Rowland, Stanley E Althof, Philippe Cote-Leger","doi":"10.1093/jsxmed/qdaf113","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf113","url":null,"abstract":"<p><strong>Background: </strong>Although the lifelong and acquired subtypes of premature ejaculation (PE) have long been acknowledged, other putative PE subtypes have garnered less consideration.</p><p><strong>Aim: </strong>This study aimed to describe a potentially unrecognized form of PE characterized by episodic or intermittent symptomology rather than regular, consistent symptomology.</p><p><strong>Methods: </strong>From an online sample of 409 men with PE, 31 identified as specifically having intermittent PE (IPE) rather than either lifelong PE (LPE) or acquired PE (APE). Data regarding PE symptomology-including lack of ejaculatory control, foreplay time and estimated ejaculation latencies (ELs) during PE episodes, foreplay time and estimated ELs during non-PE episodes, and other sexual characteristics-were collected to better describe and understand this group of men.</p><p><strong>Outcomes: </strong>Determination of sexual and ejaculatory response characteristics of men with IPE.</p><p><strong>Results: </strong>Men with IPE exhibited PE-typical responses during 40%-90% of their partnered sex episodes (mean ≈ 70%). Depending on the type of partnered sex, mean EL responses during PE episodes ranged from anteportal ejaculation to ~2 minutes, whereas mean EL responses during non-PE episodes ranged from ~3 to 6.5 minutes (P < .001). EL comparisons were also made across types of partnered sex and masturbation.</p><p><strong>Clinical implications: </strong>Some men exhibit PE-like symptoms, but do so only episodically or intermittently, a pattern that would technically prevent them from receiving treatment for PE according to most professional PE definitions.</p><p><strong>Strengths and limitations: </strong>This study is the first to detail the sexual and EL characteristics of men who experience PE intermittently. The limitations include issues regarding generalizability due to the relatively small sample size and the inherent bias possible in online studies about sexuality.</p><p><strong>Conclusion: </strong>Men with IPE show all the characteristics of men with LPE and APE, except in the consistency with which their symptoms are manifested. Such men would qualify for treatment under ICD-11 guidelines but not under other professionally based diagnostic criteria.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity may be more associated with disordered eating behaviors, somatization, insecure attachment styles, and sexual dysfunction: an exploratory study. 一项探索性研究表明,肥胖可能与饮食失调、躯体化、不安全的依恋方式和性功能障碍有关。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-08 DOI: 10.1093/jsxmed/qdaf133
Elena Colonnello, Anna Guidi, Beatrice Di Lazzaro, Chandra Massetti, Tommaso B Jannini, Lucio Gnessi, Carla Lubrano, Erika Limoncin, Andrea Sansone, Giacomo Ciocca
{"title":"Obesity may be more associated with disordered eating behaviors, somatization, insecure attachment styles, and sexual dysfunction: an exploratory study.","authors":"Elena Colonnello, Anna Guidi, Beatrice Di Lazzaro, Chandra Massetti, Tommaso B Jannini, Lucio Gnessi, Carla Lubrano, Erika Limoncin, Andrea Sansone, Giacomo Ciocca","doi":"10.1093/jsxmed/qdaf133","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf133","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a challenging disease due to its multifactorial pathogenesis. However, sexual health is a poorly explored aspect in these patients, and the interaction between eating behavior, psychological factors, and sexual function remains insufficiently characterized, although it may represent a key aspect in clinical management.</p><p><strong>Aims: </strong>To provide a characterization of psychological, eating, and sexual function characteristics of patients with obesity through an exploratory analysis.</p><p><strong>Methods: </strong>A cross-sectional, single-center study was carried out at Umberto I Hospital of Sapienza University of Rome (Italy), where patients with obesity (body mass index ≥30 kg/m2) were recruited. Additionally, a control group of age-matched, normal-weight (body mass index = 18-25 kg/m2) subjects was enrolled online. All subjects compiled a series of validated psychometric questionnaires that evaluated psychological distress, disordered eating behaviors, attachment styles, and sexual dysfunction.</p><p><strong>Outcomes: </strong>To evaluate the psychological distress, attachment style, disordered eating behavior, and sexual dysfunction in patients with obesity and to explore the correlations between these aspects.</p><p><strong>Results: </strong>Seventy-two patients (45 women, mean age 51.4 ± 4.3 years and 27 men, mean age 39.6 ± 16.6 years) and 76 controls (51 women, mean age 36.8 ± 14.3 years and 25 men, mean age 39.2 ± 16.6 years) were recruited. Subjects with obesity reported significantly higher scores in somatization and paranoid ideation symptoms, higher scores in food addiction and binge eating domains, and a more fearful attachment style. Women also reported lower sexual desire, arousal, and lubrication, while men showed significantly lower erectile function, orgasmic intensity, and sexual satisfaction.</p><p><strong>Clinical implications: </strong>Subjects with obesity are characterized by higher somatization, maladaptive eating behaviors, insecure attachment style, and worse sexual function compared to controls, which highlights the necessity of a multidimensional treatment approach.</p><p><strong>Strengths and limitations: </strong>A large and comprehensive battery of questionnaires was employed to examine both the clinical and the control population. However, the absence of stratification by age and the small sample size prevent the generalizability of the results.</p><p><strong>Conclusion: </strong>Our results highlight the intricate interplay between psychological, behavioral, and sexual factors in individuals affected by obesity. Further studies should focus on larger and more diverse samples and examine longitudinal trajectories of psychological and sexual health changes in response to weight-loss interventions, to assess how such interconnection may help to improve the personalization of care programs.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative efficacy of non-ablative radiofrequency and promestriene in management of the genitourinary syndrome and sexual dysfunction in cervical cancer survivors: a pilot randomized trial. 非消融射频治疗和提前避孕药治疗宫颈癌幸存者泌尿生殖系统综合征和性功能障碍的比较疗效:一项随机试验
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-03 DOI: 10.1093/jsxmed/qdaf083
Fernanda Santos Grossi, Rodrigo Rossi Balbinotti, Gabriel Cardozo Muller, Luciana Borges Chagas, Aline Caldart Tregnago, Lucia Maria Kliemann, Valentino Antônio Magno, Marcia Luiza Montalvao Appel Binda, Janete Vettorazzi
{"title":"Comparative efficacy of non-ablative radiofrequency and promestriene in management of the genitourinary syndrome and sexual dysfunction in cervical cancer survivors: a pilot randomized trial.","authors":"Fernanda Santos Grossi, Rodrigo Rossi Balbinotti, Gabriel Cardozo Muller, Luciana Borges Chagas, Aline Caldart Tregnago, Lucia Maria Kliemann, Valentino Antônio Magno, Marcia Luiza Montalvao Appel Binda, Janete Vettorazzi","doi":"10.1093/jsxmed/qdaf083","DOIUrl":"10.1093/jsxmed/qdaf083","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy for cervical cancer can lead to genitourinary syndrome (GUS), which negatively impacts sexual function and the quality of life among female cancer survivors.</p><p><strong>Objective: </strong>To evaluate the efficacy of promestriene and non-ablative radiofrequency (NARF) in treating GUS and its effects on sexual function in women who have undergone radiotherapy for cervical cancer (CC).</p><p><strong>Method: </strong>In this pilot randomized clinical trial included 24 women who had received radiotherapy and/or brachytherapy for CC within the past five years. Participants were randomized to receive treatment with promestriene cream or intravaginal (NARF). Sexual function was assessed pre- and post-treatment using the Female Sexual Function Index (FSFI). Vaginal symptoms were evaluated using a visual analog scale (VAS), and histological analyses of vaginal biopsies were performed before and after the intervention.</p><p><strong>Outcomes: </strong>The main outcomes measured were improvements in sexual function and reductions in vaginal symptoms.</p><p><strong>Results: </strong>Significant improvements in FSFI scores and reductions in vaginal symptom intensity were observed in both treatment groups. The median FSFI score increased from 13.0 to 23.1 after treatment. Histological analysis demonstrated a significant increase in epithelial thickness and an improvement in stromal quality in both groups. No significant differences were noted between the promestriene and (NARF) groups concerning sexual function improvements or symptom reduction.</p><p><strong>Clinical implications: </strong>Both promestriene and (NARF) proved effective and safe enhancing sexual function and reducing vaginal symptoms in post-radiotherapy CC survivors.</p><p><strong>Strengths and limitations: </strong>The study's strengths include its randomized design and comprehensive assessment of subjective and objective outcomes. However, the small sample size and limited follow-up period limit the generalization and long-term applicability of the findings.</p><p><strong>Conclusion: </strong>Both promestriene and (NARF) significantly improve sexual function and alleviate vaginal symptoms in women treated with radiotherapy for CC, presenting viable options for managing GUS in this patient population.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1043-1052"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the feasibility of a new non-invasive technique for improved diagnostics in vascular erectile dysfunction using an ultra-high-resolution ultrasound probe and venous compression: a proof of concept study. 利用超高分辨率超声探头和静脉压迫评估一种新的无创技术对血管性勃起功能障碍的改进诊断的可行性:一项概念验证研究。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-03 DOI: 10.1093/jsxmed/qdaf073
Andreas Gutwein, Alexander J Braun, Christoph Thalhammer, Vignes Mohan, Alberto Bovo, Hong H Keo, Nicolas Diehm
{"title":"Evaluating the feasibility of a new non-invasive technique for improved diagnostics in vascular erectile dysfunction using an ultra-high-resolution ultrasound probe and venous compression: a proof of concept study.","authors":"Andreas Gutwein, Alexander J Braun, Christoph Thalhammer, Vignes Mohan, Alberto Bovo, Hong H Keo, Nicolas Diehm","doi":"10.1093/jsxmed/qdaf073","DOIUrl":"10.1093/jsxmed/qdaf073","url":null,"abstract":"<p><strong>Introduction: </strong>Erectile dysfunction (ED) is a clinically relevant condition, particularly among older men, with vascular causes such as venous leakage and arterial insufficiency being primary contributors.</p><p><strong>Aim: </strong>This study aimed to assess the diagnostic accuracy of a novel, non-invasive approach employing ultrasound-guided venous compression to identify the primary vascular etiology in patients with ED.</p><p><strong>Methods: </strong>A proof-of-concept study was conducted involving 40 male patients with confirmed ED. High-resolution Dynamic Duplex Sonography (DSU) was performed following intracavernosal injection of alprostadil to assess penile blood flow dynamics, including peak systolic velocity (PSV) and end-diastolic velocity (EDV). In 17 patients, a compression ring was individually selected using ultrasound and applied to restrict venous outflow while maintaining arterial inflow. PSV and EDV values were compared between standard DSU and venous compression + DSU (VC-DSU) with an individual selected compression ring. In addition, diagnostic accuracy was validated against CT-arteriography and CT-cavernosography in 10 patients.</p><p><strong>Main outcomes measures: </strong>The primary outcome was an improvement in diagnostic accuracy of VC-DSU compared to standard DSU.</p><p><strong>Results: </strong>VC-DSU significantly improved detection of the primary vascular cause in ED, with an accuracy of 90% versus 20% for DSU. Under venous compression, changes in PSV served as key diagnostic markers: a marked increase indicated a venous origin, while stable or varied PSV values distinguished arterial or mixed causes. The accuracy of VC-DSU was comparable to CT cavernosography (P = 0.096), highlighting its potential as a reliable non-invasive alternative.</p><p><strong>Clinical implications: </strong>VC-DSU offers a non-invasive method to assess vascular contributions to erectile dysfunction with promising diagnostic potential to more accurately identify the vascular cause.</p><p><strong>Strengths and limitations: </strong>Key strengths of this study include its innovative, non-invasive approach and its direct comparison to cavernosography. However, the limited sample size restricts the generalizability of findings, highlighting the need for larger-scale trials to validate these results. Additionally, patient allocation to VC-DSU and cavernosography was based on willingness to participate rather than a predefined protocol, introducing a potential selection bias.</p><p><strong>Conclusion: </strong>VC-DSU represents a promising non-invasive and accurate tool that complements traditional diagnostic methods for vascular ED, particularly by enhancing the differentiation of the predominant vascular etiology.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1024-1034"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dysfunction and body image in BRCA mutation carriers before and after risk-reducing salpingo-oophorectomy: a cross-sectional study. 降低风险的输卵管卵巢切除术前后BRCA突变携带者的性功能障碍和身体形象:一项横断面研究
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-03 DOI: 10.1093/jsxmed/qdaf078
Flavia Sorbi, Elisa Farsi, Elisa Maseroli, Gretha Orlandi, Claudia Giglioni, Srdjan Saso, Giorgio Bogani, Massimiliano Fambrini, Linda Vignozzi, Felice Petraglia
{"title":"Sexual dysfunction and body image in BRCA mutation carriers before and after risk-reducing salpingo-oophorectomy: a cross-sectional study.","authors":"Flavia Sorbi, Elisa Farsi, Elisa Maseroli, Gretha Orlandi, Claudia Giglioni, Srdjan Saso, Giorgio Bogani, Massimiliano Fambrini, Linda Vignozzi, Felice Petraglia","doi":"10.1093/jsxmed/qdaf078","DOIUrl":"10.1093/jsxmed/qdaf078","url":null,"abstract":"<p><strong>Background: </strong>BRCA mutation carriers opting for prophylactic risk-reducing salpingo-oophorectomy (RRSO) face potential impacts on sexual functioning and body image.</p><p><strong>Aim: </strong>The aim of the study was to assess the extent of sexual dysfunction (SD) and body image impairment in BRCA patients, both with and without cancer, and before and after undergoing RRSO.</p><p><strong>Methods: </strong>The present cross-sectional study involved a group of BRCA-positive patients (n = 220) from the Gynecological Hereditary Cancer Risk Clinic, categorized into two different subgroups: A-premenopausal and B-postmenopausal women, with (1) or without and (2) a breast cancer (BC) diagnosis. Before RRSO and at a 6-month follow-up assessment, all participants were requested to complete a validated survey on body image (the Body Image Scale), sexual functioning (Female Sexual Function Index), and psychological well-being (the Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality Index fatigue subscale of the Functional Assessment of Chronic Illness Therapy-Fatigue).</p><p><strong>Outcomes: </strong>The outcomes include scores on measures of body image, sexual functioning, and psychological well-being across the four study groups (A1-premenopausal women with BC, A2-premenopausal women without BC, B1-postmenopausal women with BC, and B2-postmenopausal women without BC).</p><p><strong>Results: </strong>After RRSO, a significant decrease in sexual function and body image was observed across all groups (P < 0.01 in A1 and B1 groups and P < 0.02 in A2 and B2 groups). The most relevant changes were observed in the premenopausal and cancer-affected BRCA carriers (A2) (P < 0.001). The multivariate logistic regression analysis identified obesity, prior cancer, depression, and fatigue as risk factors for SD, while younger age and hormone replacement therapy emerged as protective factors.</p><p><strong>Clinical implications: </strong>Surgical menopause, body image concerns, anxiety, and depression contribute to the observed SD following RRSO and should be addressed by healthcare providers.</p><p><strong>Strengths and limitations: </strong>This study's strength lies in its comprehensive evaluation of the impact of RRSO on BRCA mutation carriers, both before and after the procedure. The assessment includes measures of anxiety and fatigue. The limitations of the study include possible selection bias among participants, the lack of measures for sexual distress and a control group without BRCA mutation, and the limited number of patients without SD.</p><p><strong>Conclusion: </strong>Patients undergoing RRSO frequently experience substantial psychosexual dysfunction; therefore, preoperative counseling is necessary to mitigate the incidence of SD and body image concerns in this population.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1062-1068"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating virility: penile enhancement and the evolving landscape of masculinity. 导航男子气概:阴茎增强和男子气概的演变景观。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-03 DOI: 10.1093/jsxmed/qdaf096
Duc Van Nguyen, Long Hoang Vo, An Minh Nguyen
{"title":"Navigating virility: penile enhancement and the evolving landscape of masculinity.","authors":"Duc Van Nguyen, Long Hoang Vo, An Minh Nguyen","doi":"10.1093/jsxmed/qdaf096","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf096","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 6","pages":"989-990"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Improved psychosexual wellbeing with administration of combined Sildenafil plus Melatonin compared than either drug alone in management of women with polycystic ovarian syndrome: a 3-month randomized clinical study. 修正:一项为期3个月的随机临床研究:与单用任何一种药物治疗多囊卵巢综合征相比,西地那非联合褪黑素治疗改善了女性的性心理健康。
IF 3.3 3区 医学
Journal of Sexual Medicine Pub Date : 2025-06-03 DOI: 10.1093/jsxmed/qdaf099
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引用次数: 0
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