Journal of Sexual Medicine最新文献

{"title":"Comparative study of vancomycin/gentamicin versus 0.05% chlorhexidine gluconate solution dip and irrigation in hydrophilic coated penile implants.","authors":"Edward Karpman, Ryan Griggs, Carolyn Twomey, Gerard D Henry","doi":"10.1093/jsxmed/qdaf142","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf142","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on phalloplasty: a social media sentiment analysis.","authors":"Joyce J Zhu, Payton Kotlarz, Carson Bair, Jenna Stoehr, Brielle Weinstein","doi":"10.1093/jsxmed/qdaf141","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf141","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of penile anatomy with MRI: a practical assessment of anatomical variations.","authors":"Caner Baran, Mehmet Gökhan Çulha, Kahraman Aksoy, Recep Yılmaz Bayraktarlı, Levent Özcan, Alper Ötünçtemur","doi":"10.1093/jsxmed/qdaf139","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf139","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the success of corporoplasty based on geometric principles in patients with congenital penile curvature.","authors":"Mert H Özbilen, Burak Sağmak, Mehmet Ç Çakıcı, Lokman Ayhan, Ferhat Keser, Süleyman B Kartal, Adem Altunkol, Ergün Alma, Hakan Erçil, Yalçın K Evliyaoğlu","doi":"10.1093/jsxmed/qdaf143","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf143","url":null,"abstract":"<p><strong>Background: </strong>Data on factors affecting the success of incisional corporoplasty based on the geometric principles in congenital penile curvature (CPC) are limited.</p><p><strong>Aim: </strong>To compare the pubertal status (prepubertal and postpubertal), degree of curvature (<60° and ≥60°), direction of curvature (ventral, dorsal, lateral, ventrolateral), curvature plane (monoplanar or multiplanar) and to investigate the factors affecting success in patients who underwent incisional corporoplasty based on geometric principles due to CPC.</p><p><strong>Methods: </strong>A total of 79 patients who underwent incisional corporoplasty based on geometric principles between 2016 and 2024 in two tertiary care referral centers were evaluated. The surgical technique we apply to our patients is a modification of incisional corporoplasty. This technique is based on the geometric principles of the Egydio technique. Success was defined as complete satisfaction of the patient and/or patient's parent and absence of recurrence of curvature.</p><p><strong>Outcomes: </strong>Satisfaction, success, complication rates in patients who underwent incisional corporoplasty based on geometric principles due to CPC and comparison of these patients in terms of the pubertal status (prepubertal and postpubertal), degree of curvature(<60° and ≥60°), direction of curvature (ventral, dorsal, lateral, ventrolateral), curvature plane (monoplanar or multiplanar).</p><p><strong>Results: </strong>The success rate in our study was found to be 82.2% and the total complication rate was determined as 26.5%. The success rate was 90.5% in patients in the prepubertal period, and 79.3% in patients in the postpubertal period (P = 0.331). Success occurred 82% of patients with a curvature <60°, while this rate was 82.8% in patients with a curvature of ≥60° (P = 0.396). Success was found to be 75% for multiplanar curvature and 83.1% for monoplanar curvature (P = 0.626). In regression analysis, it was found that age (P = 0.185), puberty status (P = 0.263), degree of curve (P = 0.770), direction of curve (P = 0.927), presence of multiplanar curve (P = 0.573) and operation time (P = 0.924) did not affect success. According to Kaplan-Meier analysis the P-values ​​for puberty status, degree of curvature, curvature plane and curvature direction were found to be 0.575, 0.720, 0.845, and 0.819, respectively.</p><p><strong>Clinical implications: </strong>Modification of incisional corporoplasty based on the geometric principles of the Egydio technique is an effective method in patients with CPC, regardless of age and curvature characteristics.</p><p><strong>Strengths and limitations: </strong>The lack of a group to compare this technique with other techniques, small sample size, the retrospective design of the study, the results being based on patient-reported results. The results discussed may cause bias because they are based on patient reports and do not include standard questionnaire","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High social vulnerability impacts severity of erectile function at time of urologic referral.","authors":"David Y Song, Carl A Ceraolo, Soumya Konar, Gareth Warren, Scott O Quarrier","doi":"10.1093/jsxmed/qdaf144","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf144","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual functioning after vaginal natural orifice transluminal endoscopic surgery: combined results of two randomized controlled trials.","authors":"Sofia Prekatsounaki, Jan J A Bosteels, Jan F Baekelandt, Ben W J Mol, Paul Enzlin","doi":"10.1093/jsxmed/qdaf132","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf132","url":null,"abstract":"<p><strong>Objective: </strong>To explore women's sexual functioning and associated quality of life after vaginal natural orifice transluminal endoscopic surgery (vNOTES) as an alternative to laparoscopy.</p><p><strong>Design: </strong>Two parallel group, 1:1 randomized single-centre single-blinded trials comparing the effects of vNOTES and laparoscopy.</p><p><strong>Setting: </strong>Gynaecology unit of a Belgian teaching hospital.</p><p><strong>Population: </strong>Women aged between 18 and 70 years with a benign indication for hysterectomy or adnexectomy.</p><p><strong>Methods: </strong>After informed consent, women were randomized for vNOTES (experimental group) or laparoscopy (control group). Participants and outcome assessors were blinded. Paper and pencil questionnaires before surgery, as well as at 3 and 6 months after surgery.</p><p><strong>Main outcome measures: </strong>The outcome of interest in this secondary analysis was sexual functioning at 3 and 6 months after surgery. We additionally measured quality of life.</p><p><strong>Results: </strong>We studied 68 women allocated to the vNOTES (experimental) condition and 67 women allocated to the laparoscopy (control) condition. No significant effects of time, type of surgery, and surgical technique were found on patients' sexual function. At 3 and 6 months post-surgery, an increasing number of negative associations were found between quality of life and aspects of sexual functioning.</p><p><strong>Conclusions: </strong>vNOTES applied for hysterectomy and adnexectomy as compared to laparoscopy does not have a differential impact on women's sexual functioning. Sexual function has few links to patients' quality of life before surgery, but grows in relevance as a negative correlate of quality of life after surgery.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel control for erectile dysfunction research.","authors":"Jiangping Deng, Alexandra Triko, Alberto Colombo, Ervin Kocjancic, Omer Acar, Samuel Ohlander, Daniel A Harrington, Kevin T McVary, Carol A Podlasek","doi":"10.1093/jsxmed/qdaf135","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf135","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Erectile dysfunction (ED) is a serious medical condition that impacts quality of life. An underlying cause is loss of cavernous nerve (CN) innervation, which initiates remodeling of the corpora cavernosa of the penis, including smooth muscle apoptosis and increased collagen. There are few studies of penile remodeling in patients because of difficulty acquiring patient corpora cavernosa tissue, and appropriate controls; however, it is critical to ensure that our animal models adequately parallel patient conditions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Penile morphology was examined in corpora cavernosa of reconstruction and Lapeyronie's patients, to determine if reconstruction corpora cavernosa may be useful as controls for morphological analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Penis tissue was obtained from penectomy surgery within the context of genital reconstruction (n = 25) and corpora cavernosa tissue from Lapeyronie's (control, n = 10) patients undergoing prosthesis implantation surgery. Primary cell cultures were established from corpora cavernosa tissue and growth in response to Sonic hedgehog (SHH) treatment and inhibition, BMP4, and GREM1, were quantified. The effect of 17 β-estradiol on smooth muscle cultures was examined.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Collagen was quantified by hydroxyproline assay and smooth muscle by western (α-actin/GAPDH) of corpora cavernosa tissue. Immunohistochemical (IHC) analysis for α-ACTIN, CD31, P4HB, and nNOS and trichrome stain were performed to characterize the reconstruction tissue in comparison to Lapeyronie's controls.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No differences in collagen and smooth muscle abundance were observed in the corpora cavernosa of reconstruction and Lapeyronie's patients. IHC showed normal smooth muscle, endothelium, fibroblasts, neurons, collagen, and SHH signaling in corpora cavernosa from reconstruction patients in comparison to Lapeyronie's controls. 17 β-estradiol treatment did not alter smooth muscle cell growth or the response to SHH pathway signaling.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical translation: &lt;/strong&gt;Most reconstruction patients undergo 17 β-estradiol treatment prior to surgery. While studies document the effect of estrogen on penile embryogenesis and hypospadias, little is known about estrogen impact on adult corpora cavernosa tissue. No difference in penile morphology, smooth muscle, and collagen abundance was observed in reconstruction patients who underwent 17 β-estradiol and anti-androgen treatment prior to surgery, suggesting that corpora cavernosa from these patients might be useful as controls for studies of ED.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;While no difference in corpora cavernosa morphology was observed, genomic and erectile function analyses were not performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;No difference in penile morphology was observed in the corpora cavernosa of Lapeyronie's and reconstruction patients, suggesting th","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are some forms of delayed/inhibited ejaculation more intractable than others? Establishing delayed ejaculation subtypes based on severity of symptomology during partnered sex and masturbation.","authors":"David L Rowland, Sean M McNabney, Zsuzsanna Kövi, Krisztina Hevesi","doi":"10.1093/jsxmed/qdaf105","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf105","url":null,"abstract":"<p><strong>Background: </strong>Men with delayed ejaculation (DE) do not represent a homogenous group, yet only a handful of studies have investigated the subtypes, etiology, and significant covariates of this sexual dysfunction.</p><p><strong>Aim: </strong>To identify differences in sexual functioning/responsivity and sexual behavior between DE subtypes characterized by men who experience symptomology during both partnered sex and masturbation (DE-ALLSEX group) vs men who experience symptomology only during partnered sex (DE-PARTSEX group).</p><p><strong>Method: </strong>After categorizing men into subtypes, groups were compared on variables related to demographics, sexual history, sexual response and functioning, preferred sexual activities during partnered sex and masturbation, and perceived causes of/attributions for their DE problem. Using logistic regression, a set of non-collinear differentiating variables was then used to predict DE-ALLSEX vs DE-PARTSEX group membership.</p><p><strong>Results: </strong>Relative to the DE-PARTSEX group, higher age, higher medication use, having multiple partners, and lower affinity for and pleasure during masturbatory activity predicted DE-ALLSEX group membership. Lower perceived penile sensitivity during masturbation, greater engagement in insertive anal intercourse, and perceived insufficient levels of masturbatory arousal also characterized this group. The strongest predictors of group membership were age and capacity to reach/frequency of orgasm during masturbation, with arousal level during masturbation and likelihood of engaging in penetrative anal sex also distinguishing between the two groups.</p><p><strong>Clinical translation: </strong>Although the relationship between masturbation activities and subtype membership is most likely bidirectional, the pervasiveness of masturbation activities as group-differentiating factors suggests avenues of clinical exploration in men presenting with DE symptomology.</p><p><strong>Strengths and limitations: </strong>This is the first study to attempt to understand and differentiate DE-ALLSEX and DE-PARTSEX subgroups, with a number of factors emerging as significant. However, cause-effect relationships between covariates and group membership remain elusive, and a larger sample size would have enabled investigation of a select group of DE men having only the most severe symptomology.</p><p><strong>Conclusion: </strong>Factors related to more pervasive problems with DE that affect ejaculatory capacity during both partnered and solo sex include medical, relational, arousal-related, and behavioral (masturbation and partnered sex) variables. Such factors represent potential discussion points during intake and treatment for men experiencing problems reaching ejaculation.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Are some forms of delayed/inhibited ejaculation more intractable than others? Establishing delayed ejaculation subtypes based on severity of symptomology during partnered sex and masturbation.","authors":"Nikola Komlenac","doi":"10.1093/jsxmed/qdaf106","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf106","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of collagenase clostridium histolyticum in treating primary hourglass deformities in atypical Peyronie's disease patients.","authors":"Dyvon T Walker, Majdee M Islam","doi":"10.1093/jsxmed/qdaf137","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf137","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}