Journal of Sexual Medicine最新文献

{"title":"Response to Letter to the Editor on \"Standardized multidisciplinary care for children and adolescents with differences of sex development: a health intelligence approach\".","authors":"Lieve A Willemsen, Matthijs Stoter, Emmy van den Boogaard, Stephanie Both, Luitzen A Groen, Baudewijntje P C Kreukels, Kimberly C Kuiper, Julia N Nieuwersteeg, Noortje A Roussel, Liesbeth van der Sluijs Veer, Annelou L C de Vries, Petra J G Zwijnenburg, Martin den Heijer, Jaap Oosterlaan, Sabine E Hannema","doi":"10.1093/jsxmed/qdag064","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag064","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of sexual dysfunction in commonly used United States Medical Licensing Examination step exam-specific third-party resources.","authors":"Emilyann Key, Kristina Dzara, Rachel Rubin, Aidan Ruth","doi":"10.1093/jsxmed/qdag078","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag078","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cosmetic penile enhancement procedures: an SMSNA position statement.","authors":"","doi":"10.1093/jsxmed/qdag104","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag104","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and neurotransmitter metabolic profiling in a rat model simulating hypoactive sexual desire disorder.","authors":"Guanjian Li, Qunshan Shen, Cong Ma, Chao Wang, Bing Song, Yunxia Cao","doi":"10.1093/jsxmed/qdag067","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag067","url":null,"abstract":"<p><strong>Background: </strong>Hypoactive Sexual Desire Disorder (HSDD) is a highly prevalent, clinically impactful female sexual health condition whose pathogenesis is closely associated with disrupted excitation-inhibition homeostasis in the central nervous system, while the mechanistic role of gut microbiota in this pathological process via the gut-brain axis remains largely unelucidated.</p><p><strong>Aim: </strong>To explore gut microbiota-neurotransmitter interactions in an HSDD-simulating rat model and verify their causal role via fecal microbiota transplantation (FMT).</p><p><strong>Methods: </strong>Female Sprague-Dawley rats were stratified into high copulatory behavior, normal copulatory behavior (NCB), and reduced copulatory behavior (RCB) groups via quantified mating behavioral assays, with the RCB phenotype used to establish a preclinical rat model simulating the core features of human HSDD. FMT was performed in four experimental groups: RCB-FMT-RCB, NCB-FMT-NCB, RCB-FMT-NCB, and NCB-FMT-RCB. Gut microbial composition was characterized by 16S rRNA gene sequencing, and prefrontal cortex (PFC) neurotransmitter levels were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sexual behavioral parameters were assessed following FMT administration.</p><p><strong>Outcomes: </strong>Determined gut microbial and PFC neurotransmitter differences between RCB and normal rats, and validated FMT's regulatory effects on recipients' copulatory behavior, gut microbiota, and neurotransmitter balance.</p><p><strong>Results: </strong>Compared with NCB rats, RCB rats exhibited a distinct microbial biomarker profile, characterized by enrichment of Oscillibacter and Bacteroides and depletion of Jeotgalicoccus. In the PFC, RCB rats had elevated levels of inhibitory neurotransmitters (5-HT, GABA) and 5-HIAA, alongside reduced levels of excitatory neurotransmitters (DOPA, Glu). FMT induced phenotypic transfer: NCB-FMT-RCB rats displayed diminished sexual desire and developed RCB-like microbial and neurotransmitter profiles, while RCB-FMT-NCB rats exhibited improved copulatory behavioral endpoints and partial normalization of PFC neurotransmitter levels. Spearman's correlation analysis demonstrated that Oscillibacter and Bacteroides abundances were correlated with neurotransmitter imbalance in the PFC.</p><p><strong>Clinical implications: </strong>This study provides novel preclinical insights into the role of the gut-brain axis in HSDD, supporting further exploration of gut microbiota as a potential research target for HSDD.</p><p><strong>Strengths and limitations: </strong>Strengths include a validated RCB rat model, bidirectional FMT for causality; limitations involve the inability to assess subjective distress in rodents, rat-human physiological differences, PFC-only neurotransmitter analysis, unclear molecular pathways, and lack of long-term data.</p><p><strong>Conclusions: </strong>Gut microbial dysbiosis contributes to RCB (sim","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A close look at the evidence on low-intensity shockwave therapy in erectile dysfunction-a systematic review and meta-analysis of randomized controlled trials.","authors":"Chia-Hao You, Yi-No Kang, Yu-Ching Wen, Liang-Ming Lee, Ke-Hsun Lin, Chi-Hao Hsiao, Syuan-Hao Syu, Chung-Howe Lai, Cho-Hsing Chung, Cheng-Li Kao, Sheng-Chieh Chou, Yung-Wei Lin","doi":"10.1093/jsxmed/qdag070","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag070","url":null,"abstract":"<p><strong>Introduction: </strong>Erectile dysfunction (ED), defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance, is a prevalent condition among men and has a significant impact on quality of life. Among the emerging therapeutic options, low-intensity extracorporeal shockwave therapy (LI-ESWT) has gained attention due to its proposed regenerative effects. Despite a growing number of studies suggesting the efficacy of LI-ESWT, the overall quality of the evidence remains limited, with heterogeneity in treatment protocols and study designs.</p><p><strong>Objectives: </strong>This study aims to synthesize the available evidence from randomized controlled trials (RCTs) to identify and evaluate the therapeutic parameters associated with optimal outcomes of LI-ESWT in the treatment of ED. By clarifying treatment protocols, this review seeks to provide guidance for clinical practice and inform future research design.</p><p><strong>Methods: </strong>Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the study protocol was registered with PROSPERO (CRD42024581988). Searches were conducted in PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov up to October 30, 2024, to evaluate the efficacy of the therapy. Risk of bias was evaluated using the Cochrane risk-of-bias tool (version 2, RoB 2) for the included RCTs. As for the heterogeneity across the RCTs, subgroup and meta-regression analyses were conducted to mitigate heterogeneity and identify the most effective treatment protocols.</p><p><strong>Results: </strong>Nineteen RCTs met our inclusion criteria. The majority of included studies exhibited important methodological limitations, most notably the limited use of the International Index of Erectile Function erectile function domain (IIEF-EF; 6 items) as the standardized outcome measure. Pooled analyses demonstrated that LI-ESWT significantly improved erectile function at 1-month, 3-month, and 6-month follow-ups, with statistically significant improvements in IIEF. However, confidence in long-term effects was reduced due to the limited number of studies reporting 6-month outcomes. Meta-regression analyses indicated that treatment frequency and pulse number per course were associated with therapeutic response.</p><p><strong>Conclusions: </strong>Although several RCTs demonstrated statistically significant improvements in erectile function following LI-ESWT, the majority of studies failed to achieve the minimally clinically important difference. Therefore, based on the currently available evidence, it remains unclear whether LI-ESWT provides a clinically meaningful benefit for ED at the present time. No definitive conclusions can be drawn regarding the superiority of any specific treatment regimen.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KH-001 delays para-chloroamphetamine-induced ejaculation in anaesthetized rat.","authors":"Thomas Pfeiffer, Nigel Gericke, Mahita Razanakolona, Delphine Behr-Roussel, Manon Bracconi, Francois Giuliano, Ryan Protzko","doi":"10.1093/jsxmed/qdag044","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag044","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor on \"Standardized multidisciplinary care for children and adolescents with differences of sex development: a health intelligence approach\".","authors":"Kishankumar Mahida, Snehal Rajendra Jagtap","doi":"10.1093/jsxmed/qdag057","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag057","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of serum Nesfatin-1 as a novel biomarker in premature ejaculation: its association with the serotonergic system and diagnostic value.","authors":"Peichao Guo, Xuekang Zhan, Zhenxing Hu","doi":"10.1093/jsxmed/qdag082","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag082","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelic research and sexuality: opportunities and pitfalls.","authors":"Hendrikus Knegtering, Thalia Herder, Nynke Boonstra, Symen Kornelis Spoelstra","doi":"10.1093/jsxmed/qdag025","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag025","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort\".","authors":"Ali Furkan Batur, Murat Gül","doi":"10.1093/jsxmed/qdag015","DOIUrl":"https://doi.org/10.1093/jsxmed/qdag015","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"23 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}