{"title":"Letter to the Editor on \"Timing of puberty suppression in transgender adolescents and sexual functioning after vaginoplasty (Van der Meulen et al., 2024)\".","authors":"Alison Clayton, Jilles Smids, Kathleen McDeavitt","doi":"10.1093/jsxmed/qdaf030","DOIUrl":"10.1093/jsxmed/qdaf030","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"982-983"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celeste Manfredi, Giorgio Ivan Russo, Paolo Capogrosso, Marco Falcone, Ioannis Sokolakis, Nadja Schoentgen, Andrey Morozov, Mazhar Ortaç, Afonso Morgado, Marco Capece, Davide Arcaniolo, Javier Romero-Otero, Riccardo Autorino, Marco De Sio, Laurence Levine
{"title":"Injection therapy in the acute phase of Peyronie's disease: a systematic review of current evidence.","authors":"Celeste Manfredi, Giorgio Ivan Russo, Paolo Capogrosso, Marco Falcone, Ioannis Sokolakis, Nadja Schoentgen, Andrey Morozov, Mazhar Ortaç, Afonso Morgado, Marco Capece, Davide Arcaniolo, Javier Romero-Otero, Riccardo Autorino, Marco De Sio, Laurence Levine","doi":"10.1093/jsxmed/qdaf044","DOIUrl":"10.1093/jsxmed/qdaf044","url":null,"abstract":"<p><strong>Background: </strong>Injection therapy has emerged as a possible treatment for the acute phase of Peyronie's disease (PD).</p><p><strong>Aim: </strong>To systematically review the current evidence on the efficacy and safety of injection therapy for patients in the acute phase of PD.</p><p><strong>Methods: </strong>A comprehensive bibliographic search on the MEDLINE, Scopus, and Web of Science Core Collection databases was conducted in June 2024. Articles were selected if they included patients with PD in acute phase (P) undergoing injection therapy (I) with or without comparison with other treatments (C), evaluating its efficacy or safety (O). Prospective and retrospective original studies were included (S). Articles were assessed for risk of bias using Cochrane risk-of-bias tool for randomized trials version 2, risk of bias in non-randomized studies-of interventions, and Joanna Briggs Institute critical appraisal tool. Data were synthesized narratively.</p><p><strong>Outcomes: </strong>Primary outcomes were penile curvature, penile pain, and adverse events.</p><p><strong>Results: </strong>A total of 20 studies (1291 patients) were included, with 4 (20%) being randomized controlled trials. The mean/median duration of PD symptoms ranged from 2.0 to 18.6 months across the papers. The injectable agents tested included calcium channel blockers, hyaluronic acid, Collagenase Clostridium histolyticum, interferon, and corticosteroids. In most studies, improvements in penile curvature and pain were observed, with variable magnitude and in a varying percentage of patients. Adverse events were mostly mild and localized, including bruising, swelling, and ecchymosis. No severe complications were reported in any of the studies.</p><p><strong>Clinical implications: </strong>Limited evidence support the feasibility of injection therapy for the acute phase of PD.</p><p><strong>Strengths and limitations: </strong>The first systematic review on injection therapy for acute PD. Low-to-intermediate quality and heterogeneous methodology of primary studies, impossibility of reliable quantitative data synthesis.</p><p><strong>Conclusion: </strong>Injection therapy for the acute phase of PD demonstrates variable efficacy depending on the agent used and a relatively favorable safety profile; however, the overall quality of evidence remains low and is characterized by significant methodological limitations.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"799-812"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical malpractice after treatment of Peyronie's disease.","authors":"Zachary Boston, Imran Khawaja, Mahima Gurushankar, Meher Pandher, Aleksandar Popovic, Kunj Jain, Rhea Prabhu, Amjad Alwaal","doi":"10.1093/jsxmed/qdaf040","DOIUrl":"10.1093/jsxmed/qdaf040","url":null,"abstract":"<p><strong>Background: </strong>Peyronie's Disease is a fibrotic tunica albuginea disorder resulting in penile deformity.</p><p><strong>Aim: </strong>This analysis provides an important investigation of medical malpractice cases related to the treatment of Peyronie's Disease.</p><p><strong>Methods: </strong>The LexisNexis+ and Westlaw databases were used to access all federal and state cases as well as jury verdicts and settlements. The databases were queried for the term \"Peyronie Disease\" and \"Peyronie's Disease\" between the years 1980 and 2024. One author manually reviewed all cases to find cases involving a patient suing the urologist or medical system after treatment for Peyronie's disease. Cases that did not sue the urologist in question and cases not directly pertaining to the consequences of Peyronie's disease were ruled out. Cases were categorized into reasons the plaintiff sued the defendant: infection, pain, deformity, erectile dysfunction, dysfunction of penile prosthesis, failure of informed consent, incorrect diagnosis, and improper surgical technique.</p><p><strong>Outcomes: </strong>The main outcome was which chief allegations commonly lead to medical malpractice litigation.</p><p><strong>Results: </strong>Investigation of the LexisNexis+ database yielded 76 cases. The Westlaw database offered 165 cases. After exclusion criteria, 22 cases were included from the LexisNexis+ database and an additional seven cases not identified in LexisNexis were included from Westlaw for a total of 29 cases. Fifteen of the cases ruled in favor of the defendant. Thirteen cases ruled in favor of the plaintiff with awards ranging from $97 500 to $3 971 917. The most common cause for litigation included dysfunction of a penile prosthesis, which was a precipitating issue in 37.9% of cases. Patients experiencing post-treatment infection were alleged in 34.5% of cases. Failure of informed consent was alleged in 20.7% of cases. Improper surgical technique was alleged in 20.7% of cases. Among the cases that ruled in favor of the plaintiff, the most common chief allegations included dysfunction of penile prosthesis, failure of informed consent, infection, improper surgical technique, erectile dysfunction, deformity, and incorrect diagnosis. 37.9% of cases originated from the southern region of the United States. Of the 13 cases that ruled in favor of the plaintiff, 38.5% were from the South and 38.5% were from the West.</p><p><strong>Clinical implications: </strong>Urologists remain at risk of encountering medical malpractice litigation after treatment of Peyronie's Disease.</p><p><strong>Strengths and limitations: </strong>We used strict inclusion criteria to ensure consistency of analysis Peyronie's disease treatment.</p><p><strong>Conclusion: </strong>This analysis identified that allegations were most common in Southern states, with the primary allegation being dysfunction of the penile prosthesis.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"787-793"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When clinicians stumble on sexual stigma: how to get back up and prevent new falls.","authors":"Filippo M Nimbi, Celina Criss, Antonio Prunas","doi":"10.1093/jsxmed/qdaf059","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf059","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 5","pages":"671-672"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Krychman, Karishma Hemmady, Lingyao Su, Sarah Hood, Snezhana Gaifieva, Santiago Palacios
{"title":"A randomized trial on the safety and efficacy of sensate water-based and silicone-based personal lubricants for relief of intimate discomfort associated with vaginal dryness.","authors":"Michael Krychman, Karishma Hemmady, Lingyao Su, Sarah Hood, Snezhana Gaifieva, Santiago Palacios","doi":"10.1093/jsxmed/qdaf058","DOIUrl":"10.1093/jsxmed/qdaf058","url":null,"abstract":"<p><strong>Background: </strong>Personal lubricants with different formulations and properties, including ingredients designed to enhance sensation or feeling, can be used to alleviate vaginal dryness and affect sexual function. Clinical data to support their safety and efficacy are limited.</p><p><strong>Aim: </strong>Determine safety and efficacy of two sensate personal lubricants for relief of discomfort associated with vaginal dryness in female participants, and report the impact on sexual satisfaction in female participants and male partners.</p><p><strong>Methods: </strong>A two-arm, parallel design study was performed in women (18-65 years) experiencing vaginal dryness. Participants were randomized to one of two sensate lubricants (water-based [tingling] or silicone-based [warming]), which had to be used during vaginal intercourse at least once a week over a 4-week period.</p><p><strong>Outcomes: </strong>Primary outcome: change from baseline in total Female Sexual Function Index (FSFI) score after 4 weeks of lubricant use. Secondary outcomes: change from baseline in FSFI domain scores; adverse events (AE); vulvovaginal and oral tolerance; female participant and male partner perception of lubricants; improvement in sexual intimacy (assessed using Subject Perceived Questionnaires [SPQ] and Patient Global Impression of Change).</p><p><strong>Results: </strong>Sixty-six female participants completed the study. The primary endpoint (prespecified increase in FSFI ≥4 points from baseline) was achieved for both lubricants. A positive change was observed across all six FSFI domains. All AEs were mild in severity; no serious AEs were reported; the discontinuation rate was 1.5% (one female participant; warming lubricant). For both lubricants, vulvovaginal tolerance was \"good/very good\" and oral tolerance was generally \"very good\" (\"acceptable\" for one participant in each treatment arm). For both lubricants, most female participants and their male partners agreed that first penetration during vaginal sex was smoother, and there was an improvement in sexual intimacy.</p><p><strong>Clinical implications: </strong>Safety and efficacy of both lubricants containing sensate ingredients was demonstrated, giving reassurance that they can be safely recommended by healthcare professionals to relieve vaginal dryness and enhance sexual pleasure.</p><p><strong>Strengths/limitations: </strong>Evidence is provided for the safety and efficacy of two sensate lubricants for relieving vaginal dryness and improving sexual pleasure in healthy participants across a wide age range. The SPQ is not a clinically validated tool, and the sample of participants was not diverse, which may limit the generalizability of data.</p><p><strong>Conclusions: </strong>The use of sensate lubricants showed significant improvement in sexual function coupled with improved satisfaction for both male and female participants. No severe or serious AE were reported during the study period.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"746-754"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Penile remodeling, Sonic hedgehog, and fibrosis.","authors":"Carol A Podlasek","doi":"10.1093/jsxmed/qdaf048","DOIUrl":"10.1093/jsxmed/qdaf048","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 5","pages":"668-670"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pelvic pain, sexual distress and satisfaction: cross-sectional study.","authors":"Arife Büşra Karaosmanoğlu, Yasemin Erkal Aksoy, Sema Dereli Yilmaz","doi":"10.1093/jsxmed/qdaf042","DOIUrl":"10.1093/jsxmed/qdaf042","url":null,"abstract":"<p><strong>Background: </strong>Pelvic pain significantly increases sexual distress and reduces sexual satisfaction in women.</p><p><strong>Aim: </strong>The aim of this study is to identify the factors that influence women's pelvic pain, sexual distress, and satisfaction.</p><p><strong>Methods: </strong>This research was designed as a descriptive cross-sectional study. The study was conducted between June and November 2024. The study has been completed with a total of 395 women.</p><p><strong>Outcomes: </strong>The data collection forms used in the study were the Personal Information Form, the Pelvic Pain Impact Questionnaire (PPIQ), the Female Sexual Distress Scale-R (FSDS-R) and the New Sexual Satisfaction Scale (NSSS).</p><p><strong>Results: </strong>The mean scores of the PPIQ, FSDS-R, and NSSS scales for women were 9.48 ± 8.27 (min = 0, max = 32), 22.94 ± 10.35 (min = 13, max = 65) and 74.20 ± 18.53 (min = 20, max = 100), respectively.A significant positive relationship was observed between participants' total PPIQ scores and total FSDS-R scores (r = 0.418, P < 0.001), while a significant negative relationship was identified between participants' total PPIQ scores and both total NSSS scores (r = -0.247, P < 0.001) and its sub-dimension scores.</p><p><strong>Clinical implications: </strong>Healthcare professionals should ask women about pelvic pain during routine examinations, as it is associated with other problems in their lives and should be carefully assessed, supported by a multidisciplinary approach if necessary.</p><p><strong>Strengths and limitations: </strong>As the data of the study was collected online, it is limited to the women who filled in the data collection forms and cannot be generalized to the universe. However, as this study deals with issues of sexuality, the use of online data collection in a conservative society allowed participants to express their thoughts more freely.</p><p><strong>Conclusion: </strong>The study revealed a positive correlation between participants' sexual distress and their level of pelvic pain, and a negative correlation between pelvic pain and sexual satisfaction, with women experiencing pelvic pain reporting higher levels of sexual distress and lower levels of sexual satisfaction.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"778-786"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Online expressive writing intervention for the psychosexual well-being of women with a history of childhood sexual abuse: a randomized clinical trial.","authors":"Chelsea D Kilimnik, Cindy M Meston","doi":"10.1093/jsxmed/qdaf035","DOIUrl":"10.1093/jsxmed/qdaf035","url":null,"abstract":"<p><strong>Background: </strong>Sexual schema expressive writing that addresses nonconsensual sexual experiences has demonstrated initial support for improving psychosexual well-being for women with childhood sexual abuse (CSA) histories and is easily modifiable to an online modality for accessibility and scalability.</p><p><strong>Aim: </strong>The current study aimed to assess the online efficacy of a 5-session sexual schema expressive writing intervention against a daily events writing condition and an assessment-only condition for women with CSA histories.</p><p><strong>Methods: </strong>Women were initially randomized to 1 of the 2 active writing conditions (sexual schema, n = 73; daily events, n = 71); then, to minimize awareness of anticipated results, an assessment-only condition was recruited (n = 22). Outcomes were measured at baseline (T1), 3 weeks after baseline/posttreatment (T2), and at 1-month follow-up (T3). Additionally, participant-perceived change in sexual and psychological functioning across the course of the study was assessed at T2 and T3.</p><p><strong>Outcomes: </strong>Outcomes included posttraumatic stress symptoms, sexual functioning, global self-esteem, and sexual self-concept.</p><p><strong>Results: </strong>Mixed effects linear regression models controlling for participant age demonstrated significantly greater rates of change in sexual functioning and sexual self-concept for both active writing conditions (sexual schema and daily events) in comparison with the assessment-only condition, with no differences across conditions in posttraumatic stress symptoms or self-esteem. Furthermore, analyses of variance controlling for age indicated that women in the sexual schema writing condition reported significantly greater perceived change in sexual well-being and psychological well-being than the assessment-only condition, though the daily events writing condition reported significantly greater perceived change only in psychological well-being as compared with the assessment-only condition.</p><p><strong>Clinical implications: </strong>The current study provides evidence for the use of online modalities for expressive writing for women with CSA histories and supports the use of sexual schema writing paradigms for improving sexual well-being in this population.</p><p><strong>Strengths and limitations: </strong>The study is strengthened by its ecologically valid and diverse community sample and its rigorous multisession treatment protocol. The study is limited by being underpowered for some of its analyses. Additional research is needed on the daily events writing condition and ways to target more psychological outcomes in combination with sexual outcomes in online writing treatments.</p><p><strong>Conclusions: </strong>Online expressive writing paradigms that allow for guided reflection and space on how individuals' nonconsensual sexual experiences have affected their sexuality may be a fruitful strategy for many women to b","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"839-850"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gal Saffati, Taher Naeem, Daniela Orozco Rendon, Aidan Boyne, David E Hinojosa-Gonzalez, Shane Kronstedt, Beatriz S Hernandez, Basil Kaaki, Mohit Khera
{"title":"Transcutaneous electrical neural stimulation in patients with erectile dysfunction: a single arm pilot study.","authors":"Gal Saffati, Taher Naeem, Daniela Orozco Rendon, Aidan Boyne, David E Hinojosa-Gonzalez, Shane Kronstedt, Beatriz S Hernandez, Basil Kaaki, Mohit Khera","doi":"10.1093/jsxmed/qdaf072","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf072","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 5","pages":"971-972"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decompression, subcoronal internal shunting and tunneling: a novel approach for ischemic priapism.","authors":"Andrew Y Sun, Paurush Babbar","doi":"10.1093/jsxmed/qdaf062","DOIUrl":"10.1093/jsxmed/qdaf062","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"675-676"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}