Journal of Sexual Medicine最新文献

{"title":"The representation of female sexual medicine and genital anatomy in a United States Medical Licensing Exam step 1 resource.","authors":"Sri Contractor, Suvitha Viswanathan, Olivia Negris, Monica Myers, Jennifer Romanello","doi":"10.1093/jsxmed/qdaf089","DOIUrl":"10.1093/jsxmed/qdaf089","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1069-1070"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual function in women with bothersome lower urinary tract symptoms: findings from the symptoms of lower urinary tract dysfunction research network (LURN) cohort study.","authors":"C Emi Bretschneider, Caroline Smerdon, Brian Bieber, Nathan Goodrich, James Griffith, H Henry Lai, James A Hokanson, Anna C Kirby, Abigail Smith, Magaly Guerrero, Sreya Gutta, Kathryn E Flynn, Karen John, Catherine S Bradley","doi":"10.1093/jsxmed/qdaf063","DOIUrl":"10.1093/jsxmed/qdaf063","url":null,"abstract":"<p><strong>Background: </strong>Bothersome lower urinary tract symptoms (LUTS) can negatively affect the quality of life in women, including sexual function.</p><p><strong>Aim: </strong>The primary aim of the study was to explore the association between LUTS severity and sexual functioning among women with LUTS.</p><p><strong>Methods: </strong>Female participants enrolled in the Symptoms of the first Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN-I) observational cohort study with a frequency rating of at least \"sometimes\" and a bother rating of at least \"somewhat\" on at least one LUTS Tool question. LUTS and sexual function were quantified by patient questionnaires at baseline, 3 months, and 12 months after study enrollment. LUTS were assessed via the LUTS Tool, while sexual function was assessed using the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire, International Urogynecological Association-Revised (PISQ-IR). Longitudinal analyses were restricted to females with completed baseline and 12-month (or 3-month, if missing) questionnaires. Associations between baseline sexual function, clinical characteristics, and LUTS were analyzed using linear regression.</p><p><strong>Outcomes: </strong>The primary outcomes were bothersome LUTS, defined by the LUTS Tool, and sexual function, defined by the PISQ-IR.</p><p><strong>Results: </strong>Female participants (n = 528) were identified. At baseline, 245 participants were not sexually active (NSA), while 283 were sexually active (SA). Baseline characteristics of the cohort are described in Table 1; compared with NSA, SA was younger (49 vs 63 years) and more likely to be married/civil union (67% vs 43%). Less severe LUTS (10 points lower) was associated with higher (better) PISQ-IR summary and subscale scores (condition-specific, condition-impact, global quality, and arousal/orgasm subscales) for SA participants. For NSA participants, less severe LUTS was associated with higher condition-specific and condition-impact subscale scores. A subset of participants (n = 406) had follow-up data at 12 months. Longitudinally, LUTS Tool scores improved on average from baseline to 12 months by seven points, while PISQ-IR scores generally remained stable.</p><p><strong>Clinical implications: </strong>As LUTS improves, overall sexual function in SA and NSA women remains stable.</p><p><strong>Strengths and limitations: </strong>Strengths of the study include the use of a validated sexual function questionnaire, PISQ-IR, which captures sexual function in women who are not SA. Limitations of the study include the fact that participants presented to tertiary academic centers for care, which may limit the study's generalizability.</p><p><strong>Conclusion: </strong>In a large cohort of women with prospectively collected data on LUTS and sexual function, sexual function largely remained stable over time even as LUTS bother improved.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1035-1042"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between clitoral doppler flow and pelvic floor muscle tone in women without sexual dysfunction.","authors":"Luis C Franco, Laura E Dussan","doi":"10.1093/jsxmed/qdaf098","DOIUrl":"10.1093/jsxmed/qdaf098","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"991-992"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of hyperbaric oxygen therapy as an adjuvant and preventive treatment in penile prosthesis infections.","authors":"Andreu Alabat Roca, Sergi Beato García, Begoña Etcheverry Giadrosich, Núria De Fuentes Beltruz, Celia Bardella Altarriba, Evangelos Papoutsidakis, Manel Castells Esteve, Francesc Vigués Julià","doi":"10.1093/jsxmed/qdaf088","DOIUrl":"10.1093/jsxmed/qdaf088","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1074-1076"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials.","authors":"Firoozeh Raisi, Robabeh Soleimani, Azin Ahmadzadeh, Seyedeh Nasibeh Sadati, Arghavan Fakhrian, Mir Mohammad Jalali","doi":"10.1093/jsxmed/qdaf094","DOIUrl":"10.1093/jsxmed/qdaf094","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Premature ejaculation (PE) is a common male sexual dysfunction characterized by short ejaculatory latency with minimal stimulation, an inability to delay or control ejaculation, and distress or dissatisfaction due to the condition. Pharmacological therapy is central to PE management, with dapoxetine as the only approved selective serotonin reuptake inhibitor (SSRI). Off-label options, including long-acting selective serotonin reuptake inhibitors (SSRIs) (eg, paroxetine), topical anesthetics, phosphodiesterase type 5 inhibitors (eg, sildenafil), and tramadol, have also been explored. Despite numerous systematic reviews on its treatment, challenges remain due to methodological heterogeneity, variability in outcome measures, and inconsistencies in trial quality, making it difficult to draw reliable conclusions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This umbrella review of systematic reviews and meta-analyses (SR-MAs) of randomized controlled trials (RCTs) examined the efficacy of pharmacological treatments in prolonging intravaginal ejaculatory latency time (IELT) and their safety by analyzing associated adverse events in adults with PE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search of SR-MAs ranging from 1990 to 2024 was performed. Two reviewers independently screened articles, extracted data, and assessed quality of previous SR-MAs using the A Measurement Tool to Assess Systematic Reviews version 2 (AMSTAR-2) tool and the risk of bias of RCTs using Cochrane's risk-of-bias tool for randomized trials. The primary outcome of interest was IELT. Effect sizes from primary studies of all SR-MAs were extracted, and after removing overlapping RCTs, a re-meta-analysis was conducted. We appraised evidence certainty using the Grading of recommendations, Assessment, Development, and Evaluations scoring system (GRADE).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This review included 44 SR-MAs covering 65 RCTs. Only two SR-MAs rated as moderate to high quality in the AMSTAR-2 assessment. Additionally, only six out of 65 RCTs had a low risk of bias. The median follow-up for included RCTs was 7.9 months. These treatments significantly improved IELT compared to placebo, with paroxetine achieving the largest mean difference (5.64 min; 95% confidence interval [CI]: 3.50 to 9.07). However, all pharmacological treatments were associated with adverse events, with paroxetine having the lowest risk (RR: 1.5; 95% CI: 0.3 to 7.3), while risk ratios were higher for other treatments, including 4.1 for topical anesthetics, 2.4 for tramadol, and 1.8 for dapoxetine. Only topical anesthetics and paroxetine demonstrated a moderate to high rating in the GRADE assessment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Topical anesthetics, tramadol, and SSRIs significantly increase IELT. However, substantial heterogeneity among meta-analyses may limit the robustness of these findings. Future RCTs should include extended follow-up periods to better assess the long-term","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1014-1023"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoandrogenic state inhibits erectile function in rats via miR-200a-3p.","authors":"Yuan Wang, Jun Jiang, Rui Jiang","doi":"10.1093/jsxmed/qdaf081","DOIUrl":"10.1093/jsxmed/qdaf081","url":null,"abstract":"<p><strong>Background: </strong>Androgen deficiency is an important cause of erectile dysfunction (ED), and miRNAs are small-molecule RNAs with multiple biological functions. However, whether androgen deficiency affects erectile function by regulating miRNAs is unknown.</p><p><strong>Aim: </strong>The aim of the study was to investigate the differential expression of key miRNAs in the penile corpus cavernosum of castrated rats and the relationship between these miRNAs and erectile function.</p><p><strong>Methods: </strong>The expression of key miRNAs in the penile corpus cavernosum of sham-operated, castration-operated, and post-castration testosterone replacement-treated rats was detected via high-throughput sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed to identify significantly up-regulated and down-regulated miRNAs in the penile corpus cavernosum of castrated rats, functional assays and prediction and validation of target genes were performed for key miRNAs, and the relationships between the expression of key microRNAs and maximum intracavernous pressure/mean arterial pressure ratio (ICPmax/MAP) were examined.</p><p><strong>Outcomes: </strong>Significant up-regulation of miR-200a-3p in the penile corpus cavernosum of castrated rats leads to ED by activating the RhoA/Rho-kinase signaling pathway and inhibiting p-eNOS/eNOS.</p><p><strong>Results: </strong>Among these miRNAs, the expression of miR-200a-3p was significantly greater in the penile corpus cavernosum of the cast group (50.67 ± 6.91) than in that of the sham group (1.00 ± 0.09) and the cast+T group (2.07 ± 0.35) (P < 0.05). Dlc1 and p-eNOS/eNOS in the penile corpus cavernosum of the cast group were significantly lower than those of the sham and cast+T groups (P < 0.05). The over-expression of miR-200a-3p significantly inhibited the expression of Dlc1 and decreased p-eNOS/eNOS and ICPmax/MAP (P < 0.05). Inhibition of miR-200a-3p significantly up-regulated the expression of Dlc1 and elevated the ICPmax/MAP (P < 0.05).</p><p><strong>Clinical implications: </strong>Inhibition of miR-200a-3p expression and function in the penile corpus cavernosum may be a potential treatment for ED due to androgen deficiency.</p><p><strong>Strengths and limitations: </strong>This study revealed that miR-200a-3p can lead to ED by affecting the RhoA/Rho-kinase and eNOS/NO signaling pathways. However, the specific mechanism of miR-200a-3prole in ED needs to be further investigated.</p><p><strong>Conclusion: </strong>Significant up-regulation of miR-200a-3p in the penile corpus cavernosum of castrated rats inhibited Dlc1 expression, which activated the RhoA/Rho-kinase signaling pathway in smooth muscle cells and inhibited p-eNOS/eNOS in endothelial cells to suppress erectile function. Inhibiting endogenous miR-200a-3p in the penile corpus cavernosum of castrated rats may improve erectile function.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"993-1005"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic and vulvovaginal pain in medical students: insight into patient experience and gaps in medical education.","authors":"Sarah Ponce, Emily Markarian, Sara Perelmuter, Anna Patterson, Rachel S Rubin, Tanaz Ferzandi","doi":"10.1093/jsxmed/qdaf079","DOIUrl":"10.1093/jsxmed/qdaf079","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1077-1078"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean platelet volume as a neurobiological marker in lifelong premature ejaculation: insights into platelet activation and subtype stratification.","authors":"Guodong Liu, Yuyang Zhang, Xu Wu, Hui Gao, Hui Jiang, Xiansheng Zhang","doi":"10.1093/jsxmed/qdaf084","DOIUrl":"10.1093/jsxmed/qdaf084","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1071-1073"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between depression and anxiety with female sexual function in young women with polycystic ovary syndrome.","authors":"Meral Cevik Dogan, Tevfik Yoldemir","doi":"10.1093/jsxmed/qdaf050","DOIUrl":"10.1093/jsxmed/qdaf050","url":null,"abstract":"<p><strong>Background: </strong>PCOS and its associated symptoms might be related to anxiety and depressive symptoms which may influence sexual function.</p><p><strong>Aim: </strong>To investigate the association between depression and anxiety with female sexual function among women with polycystic ovary syndrome (PCOS) during reproductive age.</p><p><strong>Methods: </strong>The study group included 268 women with PCOS and 158 women without PCOS between the ages of 18 and 35 years. Serum testosterone, androstenedione, dehydroepiandrostenedione sulfate (DHEA-S), fasting glucose, sex-hormone binding globulin, and fasting insulin levels were analyzed. The McCoy Female Sexual Questionnaire (MFSQ), and Beck Anxiety and Depression Inventories (BAI and BDI) were distributed to women with PCOS and controls.</p><p><strong>Outcomes: </strong>MFSQ, BDI, and BAI scores were compared between women with PCOS and controls.</p><p><strong>Results: </strong>There was a significant difference between the PCOS and non-PCOS groups when BDI (18.92 ± 11.09 vs 10.20 ± 8.66, p = 0.001) and BAI (12.45 ± 9.67 vs 8.08 ± 8.90, p = 0.001) subgroups were compared. A weak negative correlation was present between McCoy's sexuality domain (r = -0.304), McCoy's Sexual partner domain (r = -0.215), and BAI score among PCOS women. A moderate negative correlation between McCoy's sexuality domain (r = -0.515), and a weak correlation between McCoy's Sexual partner domain (r = -0.271) and BDI score among PCOS women were found.</p><p><strong>Clinical implications: </strong>Women with PCOS report more severe depression, anxiety, and sexual dysfunction than non-PCOS women.</p><p><strong>Strengths & limitations: </strong>Socio-cultural identity, awareness, perceptions of body image, and interpersonal relations were not investigated in the current study. These play a role in the interactions between sexual dysfunction and mood disorder. The strength of our study was that the prevalence of PCOS features was different between the various depression and anxiety subgroups.</p><p><strong>Conclusion: </strong>The women with PCOS were more likely to have moderate-severe anxiety and moderate-severe depression while their mean total scores of the two domains of MFSQ were lower when compared to non-PCOS women.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"859-868"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of overactive bladder on sexual health in women with diabetes.","authors":"Cansu Polat Dunya, Arzu Erkoc, Medine Yucesoy, Mehmet Gokhan Culha, Mine Adas","doi":"10.1093/jsxmed/qdaf052","DOIUrl":"10.1093/jsxmed/qdaf052","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of overactive bladder symptoms and sexual dysfunction is increased in women with type 2 diabetes, and this can negatively impact their quality of life.</p><p><strong>Aim: </strong>To evaluate the effects of overactive bladder on sexual function and the quality of sexual life in women with and without type 2 diabetes.</p><p><strong>Methods: </strong>This cross-sectional study included 168 women who were assigned to 4 groups: healthy women (n = 42), women with overactive bladder (n = 42), women with diabetes but without overactive bladder (n = 42), and women with both diabetes and overactive bladder (n = 42). Data were collected using the Overactive Bladder 8-Question Awareness Tool, the Female Sexual Function Index, and the Sexual Quality of Life-Female questionnaire. The variables assessed with these tools were analyzed using the Kruskal-Wallis test.</p><p><strong>Outcomes: </strong>The levels of overactive bladder symptoms, sexual function, and sexual quality of life in women were evaluated.</p><p><strong>Results: </strong>The overactive bladder and sexual function scores of women with overactive bladder and women with both diabetes and overactive bladder were significantly worse compared to those of healthy women (P ˂ .001). In particular, women with both diabetes and overactive bladder had lower levels of sexual quality of life compared to women with overactive bladder and healthy women (P ˂ .001).</p><p><strong>Clinical implications: </strong>The study reveals that overactive bladder symptoms and diabetes severely affect women's quality of sexual life, emphasizing that these problems should be a routine part of clinical assessment.</p><p><strong>Strengths and limitations: </strong>The strength of the study lies in its unique approach as the first to comprehensively examine the effect of diabetes and overactive bladder on sexuality through a comparison of 4 distinct groups of women. Collecting data using valid and reliable scales and applying the STROBE checklist increases methodological rigor. However, the limited sample size restricts generalizability, and causal relationships cannot be established due to the cross-sectional design. In addition, self-reported data may increase the risk of bias.</p><p><strong>Conclusion: </strong>This study highlights that diabetes and overactive bladder symptoms negatively affect women's sexual function and sexual quality of life and that comprehensive and individualized treatment plans should be developed.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"739-745"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}