Sexual function in women with bothersome lower urinary tract symptoms: findings from the symptoms of lower urinary tract dysfunction research network (LURN) cohort study.

IF 3.3 3区 医学 Q1 UROLOGY & NEPHROLOGY
C Emi Bretschneider, Caroline Smerdon, Brian Bieber, Nathan Goodrich, James Griffith, H Henry Lai, James A Hokanson, Anna C Kirby, Abigail Smith, Magaly Guerrero, Sreya Gutta, Kathryn E Flynn, Karen John, Catherine S Bradley
{"title":"Sexual function in women with bothersome lower urinary tract symptoms: findings from the symptoms of lower urinary tract dysfunction research network (LURN) cohort study.","authors":"C Emi Bretschneider, Caroline Smerdon, Brian Bieber, Nathan Goodrich, James Griffith, H Henry Lai, James A Hokanson, Anna C Kirby, Abigail Smith, Magaly Guerrero, Sreya Gutta, Kathryn E Flynn, Karen John, Catherine S Bradley","doi":"10.1093/jsxmed/qdaf063","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bothersome lower urinary tract symptoms (LUTS) can negatively affect the quality of life in women, including sexual function.</p><p><strong>Aim: </strong>The primary aim of the study was to explore the association between LUTS severity and sexual functioning among women with LUTS.</p><p><strong>Methods: </strong>Female participants enrolled in the Symptoms of the first Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN-I) observational cohort study with a frequency rating of at least \"sometimes\" and a bother rating of at least \"somewhat\" on at least one LUTS Tool question. LUTS and sexual function were quantified by patient questionnaires at baseline, 3 months, and 12 months after study enrollment. LUTS were assessed via the LUTS Tool, while sexual function was assessed using the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire, International Urogynecological Association-Revised (PISQ-IR). Longitudinal analyses were restricted to females with completed baseline and 12-month (or 3-month, if missing) questionnaires. Associations between baseline sexual function, clinical characteristics, and LUTS were analyzed using linear regression.</p><p><strong>Outcomes: </strong>The primary outcomes were bothersome LUTS, defined by the LUTS Tool, and sexual function, defined by the PISQ-IR.</p><p><strong>Results: </strong>Female participants (n = 528) were identified. At baseline, 245 participants were not sexually active (NSA), while 283 were sexually active (SA). Baseline characteristics of the cohort are described in Table 1; compared with NSA, SA was younger (49 vs 63 years) and more likely to be married/civil union (67% vs 43%). Less severe LUTS (10 points lower) was associated with higher (better) PISQ-IR summary and subscale scores (condition-specific, condition-impact, global quality, and arousal/orgasm subscales) for SA participants. For NSA participants, less severe LUTS was associated with higher condition-specific and condition-impact subscale scores. A subset of participants (n = 406) had follow-up data at 12 months. Longitudinally, LUTS Tool scores improved on average from baseline to 12 months by seven points, while PISQ-IR scores generally remained stable.</p><p><strong>Clinical implications: </strong>As LUTS improves, overall sexual function in SA and NSA women remains stable.</p><p><strong>Strengths and limitations: </strong>Strengths of the study include the use of a validated sexual function questionnaire, PISQ-IR, which captures sexual function in women who are not SA. Limitations of the study include the fact that participants presented to tertiary academic centers for care, which may limit the study's generalizability.</p><p><strong>Conclusion: </strong>In a large cohort of women with prospectively collected data on LUTS and sexual function, sexual function largely remained stable over time even as LUTS bother improved.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1035-1042"},"PeriodicalIF":3.3000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sexual Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jsxmed/qdaf063","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Bothersome lower urinary tract symptoms (LUTS) can negatively affect the quality of life in women, including sexual function.

Aim: The primary aim of the study was to explore the association between LUTS severity and sexual functioning among women with LUTS.

Methods: Female participants enrolled in the Symptoms of the first Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN-I) observational cohort study with a frequency rating of at least "sometimes" and a bother rating of at least "somewhat" on at least one LUTS Tool question. LUTS and sexual function were quantified by patient questionnaires at baseline, 3 months, and 12 months after study enrollment. LUTS were assessed via the LUTS Tool, while sexual function was assessed using the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire, International Urogynecological Association-Revised (PISQ-IR). Longitudinal analyses were restricted to females with completed baseline and 12-month (or 3-month, if missing) questionnaires. Associations between baseline sexual function, clinical characteristics, and LUTS were analyzed using linear regression.

Outcomes: The primary outcomes were bothersome LUTS, defined by the LUTS Tool, and sexual function, defined by the PISQ-IR.

Results: Female participants (n = 528) were identified. At baseline, 245 participants were not sexually active (NSA), while 283 were sexually active (SA). Baseline characteristics of the cohort are described in Table 1; compared with NSA, SA was younger (49 vs 63 years) and more likely to be married/civil union (67% vs 43%). Less severe LUTS (10 points lower) was associated with higher (better) PISQ-IR summary and subscale scores (condition-specific, condition-impact, global quality, and arousal/orgasm subscales) for SA participants. For NSA participants, less severe LUTS was associated with higher condition-specific and condition-impact subscale scores. A subset of participants (n = 406) had follow-up data at 12 months. Longitudinally, LUTS Tool scores improved on average from baseline to 12 months by seven points, while PISQ-IR scores generally remained stable.

Clinical implications: As LUTS improves, overall sexual function in SA and NSA women remains stable.

Strengths and limitations: Strengths of the study include the use of a validated sexual function questionnaire, PISQ-IR, which captures sexual function in women who are not SA. Limitations of the study include the fact that participants presented to tertiary academic centers for care, which may limit the study's generalizability.

Conclusion: In a large cohort of women with prospectively collected data on LUTS and sexual function, sexual function largely remained stable over time even as LUTS bother improved.

有恼人的下尿路症状的女性的性功能:来自下尿路功能障碍研究网络(LURN)队列研究的结果
背景:恼人的下尿路症状(LUTS)会对女性的生活质量产生负面影响,包括性功能。目的:本研究的主要目的是探讨LUTS严重程度与LUTS女性性功能之间的关系。方法:女性受试者参加下尿路功能障碍第一症状研究网络(LURN-I)观察性队列研究,在至少一个LUTS工具问题上频率评级至少为“有时”,麻烦评级至少为“有些”。在研究入组后的基线、3个月和12个月,通过患者问卷对LUTS和性功能进行量化。通过LUTS工具评估LUTS,而性功能评估使用盆腔器官脱垂/尿失禁性问卷,国际泌尿妇科协会修订(PISQ-IR)。纵向分析仅限于完成基线和12个月(或3个月,如果缺失)问卷调查的女性。使用线性回归分析基线性功能、临床特征和LUTS之间的关系。结果:主要结果是由LUTS工具定义的烦人LUTS和PISQ-IR定义的性功能。结果:女性参与者(n = 528)被确定。基线时,245名参与者性行为不活跃(NSA), 283名参与者性行为活跃(SA)。该队列的基线特征见表1;与NSA相比,SA更年轻(49岁vs 63岁),更有可能结婚/民事结合(67% vs 43%)。对于SA参与者来说,较轻的LUTS(低10分)与较高(更好)的PISQ-IR总结和子量表得分(条件特异性,条件影响,整体质量和觉醒/性高潮子量表)相关。对于NSA参与者,较不严重的LUTS与较高的条件特异性和条件影响子量表得分相关。一部分参与者(n = 406)在12个月时有随访数据。纵向上,LUTS工具得分从基线到12个月平均提高了7分,而PISQ-IR得分总体保持稳定。临床意义:随着LUTS的改善,SA和NSA女性的整体性功能保持稳定。优势和局限性:该研究的优势包括使用了一份经过验证的性功能问卷,PISQ-IR,它捕捉了非性行为障碍女性的性功能。研究的局限性包括参与者在三级学术中心接受护理,这可能限制了研究的普遍性。结论:在大量前瞻性收集LUTS和性功能数据的女性队列中,性功能在很大程度上保持稳定,即使LUTS症状有所改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Sexual Medicine
Journal of Sexual Medicine 医学-泌尿学与肾脏学
CiteScore
6.20
自引率
5.70%
发文量
826
审稿时长
2-4 weeks
期刊介绍: The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research. The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine. The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信