Journal of Sexual Medicine最新文献

{"title":"Antimicrobial resistance and biofilm formation of penile prosthesis isolates: insights from in-vitro analysis.","authors":"Bradley J Roth, Prajit Khooblall, Navid Leelani, Mangesh Suryavanshi, Andrew Shumaker, Glenn Werneburg, Aaron Miller, Petar Bajic","doi":"10.1093/jsxmed/qdaf001","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf001","url":null,"abstract":"<p><strong>Background: </strong>Inflatable penile prostheses (IPPs) have been shown to harbor biofilms in the presence and absence of infection despite exposure to various antimicrobials. Microbes persisting on IPPs following antibiotic exposure have not been adequately studied to assess biofilm formation capacity and antibiotic resistance.</p><p><strong>Aim: </strong>In this study, we aimed to assess these properties of microbes obtained from explanted infected and non-infected IPPS using an in vitro model.</p><p><strong>Methods: </strong>35 bacterial isolates were grown and tested against various single-agent or multiple agent antibiotic regimens including: bacitracin, cefaclor, cefazolin, gentamicin, levofloxacin, trimethoprim-sulfamethoxazole, tobramycin, vancomycin, piperacillin/tazobactam, gentamicin + piperacillin/tazobactam, gentamicin + cefazolin, and gentamicin + vancomycin. Zones of inhibition were averaged for each sample site and species. Statistics were analyzed with Holm's corrected, one-sample t-tests against a null hypothesis of 0. Isolates were also allowed to form biofilms in a 96-well polyvinyl plate and absorbance was tested at 570 nm using a microplate reader.</p><p><strong>Outcomes: </strong>Resistance was determined via clinical guidelines or previously established literature, and the mean and standard deviation of biofilm absorbance values were calculated and normalized to the optical density600 of the bacterial inoculum.</p><p><strong>Results: </strong>Every species tested was able to form robust biofilms with the exception of Staphylococcus warneri. As expected, most bacteria were resistant to common perioperative antimicrobial prophylaxis. Gentamicin dual therapy demonstrated somewhat greater efficacy.</p><p><strong>Strengths and limitations: </strong>This study examines a broad range of antimicrobials against clinically obtained bacterial isolates. However, not all species and antibiotics tested had standardized breakpoints, requiring the use of surrogate values from the literature. The microbes included in this study and their resistance genes are expectedly biased towards those that survived antibiotic exposure, and thus reflect the types of microbes which might \"survive\" in vivo exposure following revisional surgery.</p><p><strong>Clinical translation: </strong>Despite exposure to antimicrobials, bacteria isolated during penile prosthesis revision for both infected and non-infected cases exhibit biofilm forming capacity and extensive antibiotic resistance patterns in vitro. These microbes merit further investigation to understand when simple colonization vs re-infection might occur.</p><p><strong>Conclusions: </strong>Although increasing evidence supports the concept that all IPPs harbor biofilms, even in the absence of infection, a deeper understanding of the characteristics of bacteria that survive revisional surgery is warranted. This study demonstrated extensive biofilm forming capabilities, and resistance patt","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes toward genderism, transphobia, and persons of the LGBT+ community of urologists and andrologists.","authors":"Bac Hoai Nguyen, Quan Minh Pham, Eric Hahn, Tam Thi Minh Ta, Kerem Böge, Solveig Kemna, Emmanuele A Jannini, Vu Bui Duy Nguyen","doi":"10.1093/jsxmed/qdaf038","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf038","url":null,"abstract":"<p><strong>Background: </strong>Despite social transitions in attitude toward the LGBT+ community, homonegativity, genderism, or transphobia persist, even found in healthcare providers (HCPs), which can hamper the goal of equality and equity in general health and that of gender minorities. The lack of knowledge about the community is also a problem, especially in developing countries.</p><p><strong>Aim: </strong>To investigate the influences of attitudes toward and knowledge about the LGBT+ community of HCPs who are not LGBT+ on how they practice in clinical settings.</p><p><strong>Methods: </strong>A survey was conducted on HCPs, mainly working in urology, nephrology, and andrology, who attended the annual congress on Urology and Nephrology in August 2023. The survey evaluated homophobia, genderism/transphobia, and knowledge about LGBT+ using the Attitude Toward Lesbians and Gay Men Scale-Short Version (ATLG-S), Genderism and Transphobia Scale-Revised-Short Form (GTS-R-SF), and Knowledge About Homosexuality Questionnaire (KAHQ). The behaviors of HCPs toward LGBT+ were also investigated.</p><p><strong>Outcome: </strong>HCPs' attitudes toward and knowledge about LGBT+ were affected by individual-related factors and modulated behaviors toward LGBT+ patients in clinical settings.</p><p><strong>Results: </strong>Among 362 qualified respondents, levels of negative attitudes toward lesbians, gay men, and transgender people are mild at 5.5%, 13.0%, and 11.1%, respectively. Most respondents (93.4%) have a low to moderate level of knowledge, as measured by the KAHQ, about the LGBT+ community. Respondents having LGBT+ friends have more positive attitudes toward LGBT+ people and higher levels of knowledge about the community than others. Findings from the structural equation model indicate that improving knowledge is the key factor to change the attitudes and practices of Vietnamese HCPs while in contact with LGBT+ clients.</p><p><strong>Clinical implications: </strong>Developing official and thoughtful curricula on the diversities of gender identities and sexual orientations for medical staff is crucial to reducing gender and sexual orientation discrimination.</p><p><strong>Strengths and limitations: </strong>This study used validated questionnaires with the ability to exclude unintended respondents, improving the analyses' accuracy. Since the sample did not represent all HCPs and other specialties, further studies are required.</p><p><strong>Conclusion: </strong>This study indicates the existence of mild levels of homophobia, genderism, and transphobia among HCPs. Improving the knowledge of HCPs about LGBT+ people plays a critical role in improving attitudes toward the community and ensuring equality and equity in providing health services for all patients regardless of their gender identity and sexual orientation.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The attitudes of transgender and gender-diverse adolescents and their parents regarding fertility, parenthood, and fertility preservation before the start of puberty suppression or gender-affirming hormone therapy.","authors":"Tessa H R Stolk, Norah M van Mello, Lidewij S Boogers, Andreas Meißner, Judith A F Huirne, Alessandra D Fisher, Silvia Ciancia, Daniel Klink, Martine Cools, Sabine E Hannema, Emmy van den Boogaard","doi":"10.1093/jsxmed/qdaf029","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf029","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Gender-affirming treatment for transgender and gender-diverse (TGD) adolescents can consist of puberty suppression (PS) and gender-affirming hormone treatment (GAHT), which may affect fertility.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aims to evaluate the attitudes and decision-making regarding parenthood and fertility preservation from TGD adolescents and their parents and analyze the fertility preservation use and outcome before the start of treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Adolescents under 18 starting PS or GAHT between November 2021 and March 2024 were enrolled in a multicenter prospective cohort study \"ENIGI adolescents,\" conducted at Amsterdam University Medical Centre, Ghent University Hospital, and Florence University Hospital. Adolescents and parents were asked to complete the \"Transgender Youth Fertility Attitudes Questionnaire\" and the \"Decision Conflict Scale.\" Information about fertility preservation use and outcomes was extracted from electronic patient files.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Attitudes from TGD adolescents and their parents regarding desire for children, fertility preservation use, outcomes, and decision-making.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 316 adolescents were counseled about fertility options; 100 (49%) registered female at birth (RFAB) and 50 (48%) registered male at birth (RMAB) adolescents expressed a future desire for children. More than 1/3 had interest in or are still undecided about having a genetic offspring. None of the RFAB TGD adolescents underwent fertility preservation. In total, 20 (22%) RMAB adolescents pursued fertility preservation, 14 before PS and 6 before GAHT. Before PS, three performed testicular sperm extraction (TESE). All others performed semen cryopreservation. The post-thawed semen quality was low. The testicular volume and Tanner stage in the semen cryopreservation group were significantly higher compared to TESE, P = .013 and P = .021, respectively. There was no significant difference in age between those groups.Adolescents experience moderate to high decisional conflict about their fertility choices. RFAB adolescents experience a significantly higher conflict in decision-making compared to RMAB adolescents (40/100 vs 34/100 95% CI [2.1-9.4]). Younger RFAB adolescents experienced more decisional conflict (B =-1,25, 95% CI [-2,25, -0.25]). In RMAB this was not significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;This study helps to further understand TGD adolescents' needs and can further improve the development of tailored fertility counseling.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This is the first European collaborative study on transgender healthcare in adolescents. A limitation of our study is the relatively low response rate to the questionnaires, which varied between 25% and 62%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Many TGD adolescents express a desire for future parenthood yet experience decisional conflict","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Known limitations and shared prioritization of sexual wellbeing: Response to Letter to the Editor.","authors":"Isabelle S van der Meulen, Marijn Arnoldussen, Anna I R van der Miesen, Sabine E Hannema, Thomas D Steensma, Annelou L C de Vries, Baudewijntje P C Kreukels","doi":"10.1093/jsxmed/qdaf031","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf031","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Timing of puberty suppression in transgender adolescents and sexual functioning after vaginoplasty (Van der Meulen et al., 2024)\".","authors":"Alison Clayton, Jilles Smids, Kathleen McDeavitt","doi":"10.1093/jsxmed/qdaf030","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf030","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining gender-specific mental health risks after gender-affirming surgery: a national database study.","authors":"Joshua E Lewis, Amani R Patterson, Maame A Effirim, Manav M Patel, Shawn E Lim, Victoria A Cuello, Marc H Phan, Wei-Chen Lee","doi":"10.1093/jsxmed/qdaf026","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf026","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Transgender individuals face heightened psychological distress, including depression, anxiety, and suicidal ideation, partly due to stigma and lack of gender affirmation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate mental health outcomes in transgender individuals with gender dysphoria who have undergone gender-affirming surgery, stratified by gender and time since surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study utilized the TriNetX database, analyzing U.S. patients aged ≥18 with gender dysphoria (International Classification of Diseases, Tenth Revision [ICD-10] F64) between June 2014 and June 2024. Six cohorts were created based on gender and surgery status: Cohorts A-D included patients with or without surgery, and Cohorts E-F allowed for gender comparison among those with surgery. Propensity score matching controlled for age, race, and ethnicity. Mental health outcomes included depression, anxiety, suicidal ideation, substance use disorder, and body dysmorphic disorder, assessed over two years post-surgery using clinician-verified ICD-10 codes. Body dysmorphic disorder (BDD) was analyzed separately and not conflated with gender dysphoria cohorts to ensure the distinction between these conditions. Statistical analysis employed risk ratios, with P &lt; 0.05 deemed significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Primary outcomes were differences in mental health disorders, specifically depression, anxiety, suicidal ideation, body-dysmorphic disorder, and substance use disorder, among transgender individuals' post-surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 107 583 patients, matched cohorts demonstrated that those undergoing surgery were at significantly higher risk for depression, anxiety, suicidal ideation, and substance use disorders than those without surgery. Males with surgery showed a higher prevalence of depression (25.4% vs. 11.5%, RR 2.203, P &lt; 0.0001) and anxiety (12.8% vs. 2.6%, RR 4.882, P &lt; 0.0001). Females exhibited similar trends, with elevated depression (22.9% vs. 14.6%, RR 1.563, P &lt; 0.0001) and anxiety (10.5% vs. 7.1%, RR 1.478, P &lt; 0.0001). Feminizing individuals demonstrated particularly high risk for depression (RR 1.783, P = 0.0298) and substance use disorders (RR 1.284, P &lt; 0.0001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Findings suggest the necessity for gender-sensitive mental health support following gender-affirming surgery to address post-surgical psychological risks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;By leveraging ICD-10 codes, we provide a more accurate representation of patient demographics and clinical outcomes, minimizing recall and reporting biases that often limit survey-based research. Limitations include the inability to account for unmeasured confounders such as social support.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Gender-affirming surgery, while beneficial in affirming gender identity, is associated with increased risk of mental health issues, u","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexuality in people assigned female at birth with spinal cord injury: the challenges encountered.","authors":"Meenakshi Goel, Claire Mazzia, Sarah Daisy Kosa, Anne Harris, Anne Berndl","doi":"10.1093/jsxmed/qdaf024","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf024","url":null,"abstract":"<p><strong>Background: </strong>Spinal Cord Injury (SCI) can impact sexual function negatively, and although most people continue to be sexually active post-injury, they often report decreased satisfaction in various aspects of sexual life.</p><p><strong>Aim: </strong>To gain insight into the sexual experience and functioning of people assigned female at birth (AFAB) with a SCI.</p><p><strong>Methods: </strong>This study is part of an international observational questionnaire examining the reproductive health outcomes of individuals AFAB with SCI. The questionnaire was distributed to SCI organizations and support groups in 33 countries in four languages between 2019 and 2021. A total of 557 individuals AFAB with SCI, between the ages of 18 and 50, who completed the sexual health questions were included in this analysis.</p><p><strong>Outcome: </strong>Scores of Female Sexual Function Index (FSFI-6) in relation to the severity of the SCI based on the American Spinal Injury Association (ASIA) impairment scale, level, and duration of SCI.</p><p><strong>Results: </strong>Nearly 65% (170/263) of the study population within 10 years of injury had sexual dysfunction (SD) (FSFI-6 score less than or equal to 19), and participants with ASIA A had the most dysfunction (Mean score 15.95 + 7.52). Interestingly, although half of the study population scores as experiencing SD, only one-third describe SD as a concern associated with SCI. Though most of the changes were of a physical nature (inability to orgasm, pain during penetration, spasticity, barriers related to bowel/bladder problems and episodes of autonomic dysreflexia), psychosocial factors like the presence of concomitant anxiety/depression and sexual violence from a partner affected their sexual lives adversely. We attempt to elucidate the strategies adopted to improve sexual satisfaction that can help professionals involved in the SCI rehabilitative process.</p><p><strong>Clinical implications: </strong>Our results provide insight into the degree of SD, factors impacting sexual satisfaction and areas which need to be emphasized during the rehabilitation process of people AFAB with SCI.</p><p><strong>Strength and limitations: </strong>This study is one of the largest of its kind, attempting to understand sexual functioning and factors impacting the sexual life of people AFAB post-SCI using a standardized tool, the FSFI score. As a voluntary survey, those who responded may not be fully representative of the population.</p><p><strong>Conclusion: </strong>Sexual health is an essential component of rehabilitation for individuals AFAB with SCI. Enhancing their sexual satisfaction requires a comprehensive approach that considers their physical, psychological and interpersonal circumstances.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early body composition changes in trans women on low-dose estradiol: comparing oral vs sublingual administration using dual energy absorptiometry and bioelectrical impedance analysis.","authors":"Iris Yaish, Assaf Buch, Guy Gindis, Yael Sofer, Mira Arbiv, Yaffa Moshe, Yona Grenman, Karen Tordjman","doi":"10.1093/jsxmed/qdaf005","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf005","url":null,"abstract":"<p><strong>Background: </strong>Low-dose sublingual estradiol gender-affirming hormone therapy (GAHT) in treatment-naive transgender women effectively suppresses testosterone and initiates breast development, comparable to oral estradiol with cyproterone acetate; however, its impact on body composition remains unstudied.</p><p><strong>Aim: </strong>To assess early body composition changes with low-dose estradiol, compare sublingual versus oral administration efficacy, and evaluate bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) agreement in transgender women undergoing GAHT.</p><p><strong>Methods: </strong>In this 6-month prospective study, 22 treatment-naïve transgender women received either 2 mg/day sublingual estradiol (SLE) or combined oral (CO)-2 mg/day oral estradiol plus 10 mg/day cyproterone acetate. Body composition was assessed using DXA and BIA at baseline and after 6 months.</p><p><strong>Outcomes: </strong>Changes in body composition, including lean body mass, fat mass, visceral fat area, waist-to-hip ratio, and android-to-gynoid fat ratio.</p><p><strong>Results: </strong>BIA and DXA measurements showed good agreement. Both groups experienced decreased lean body mass and increased fat mass. The SLE group showed less increase in total and segmental body fat, and visceral fat area compared to CO. Both treatments decreased waist-to-hip ratio and android-to-gynoid fat ratio, indicating early achievement of a more feminine body shape.</p><p><strong>Clinical implications: </strong>These findings may help optimize GAHT protocols, improve patient satisfaction with treatment, and enable monitoring outcome assessment in transgender women.</p><p><strong>Strengths and limitations: </strong>This study provides valuable insights into early body composition changes with low-dose estradiol administration via different administration routes and validates BIA as an alternative to DXA. However, the sample size was relatively small, the study arm allocation was not randomized, and the study duration was only 6 months.</p><p><strong>Conclusion: </strong>Low-dose estradiol induces significant feminizing body composition changes within 6 months of GAHT, with sublingual administration potentially limiting fat accumulation while achieving a feminine body shape.</p><p><strong>Study registration: </strong>ISRCTN15726488 Entire data set found at:  https://doi.org/10.17605/OSF.IO/VNC54.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemsex and compulsive sexual behavior among sexual minority men.","authors":"Todd L Jennings, Neil Gleason, Frankie Nieblas, Nicholas C Borgogna, Shane W Kraus","doi":"10.1093/jsxmed/qdaf021","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf021","url":null,"abstract":"<p><strong>Introduction: </strong>Chemsex, or the use of specific psychoactive substances to enhance or prolong sexual encounters, is increasingly prevalent among sexual minority men and is linked to adverse health outcomes.</p><p><strong>Aim: </strong>This study examines the co-occurrence of chemsex and compulsive sexual behavior disorder (CSBD) among sexual minority men and whether this co-occurrence is connected to mental and sexual health concerns.</p><p><strong>Methods: </strong>A sample of 289 sexual minority men (223 gay men and 66 bisexual men), recruited primarily through the dating/hookup application Grindr, completed measures of chemsex participation, CSBD, substance use disorder symptoms, and health outcomes. CSBD was measured with the Compulsive Sexual Behavior Disorder Scale-7 (CSBD-7), which uses a psychometrically validated cut-off for identifying individuals who are at high risk of experiencing CSBD.</p><p><strong>Results: </strong>Chemsex participation (15.2%) and falling above the CSBD-7 cut-off (34.3%) were prevalent, with 9.3% of participants endorsing both. Chemsex, compared to alcohol and marijuana use during sex, was more strongly associated with sexual and mental health outcomes. Individuals reporting chemsex and/or falling above the CSBD-7 cut-off, experienced greater depression and anxiety compared to those without these concerns. However, only individuals reporting the co-occurrence of chemsex and CSBD endorsed greater sexual health concerns, such as condomless anal sex and HIV infection. Participants only endorsing chemsex were not included in the analyses due to low frequency.</p><p><strong>Discussion: </strong>This study suggests that chemsex and CSBD co-occur and are connected to negative health outcomes, such as depression and condomless anal sex. Notably, differences in sexual health concerns (i.e., condomless anal sex, HIV infection, and the use of poppers and erectile dysfunction medications during sex) were only identified when participants endorsing chemsex were included in analyses, suggesting that CSBD's connection to sexual risk may arise from a subset of individuals struggling with chemsex. Lastly, chemsex, popper use, and erectile dysfunction medication use during sex appear more strongly connected to CSBD than marijuana or alcohol use during sex. Future research is needed using larger samples, longitudinal approaches, and more refined measures of chemsex.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Unlocking the potential of noninvasive neuromodulation and integrated therapies: a new era for fertility and sexual function recovery in spinal cord injury?\"","authors":"Rocco Salvatore Calabrò","doi":"10.1093/jsxmed/qdaf023","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf023","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}