Sexual function in people with multiple sclerosis: a systematic review and meta-analysis.

IF 3.3 3区医学 Q1 UROLOGY & NEPHROLOGY

Journal of Sexual Medicine Pub Date : 2025-05-28 DOI:10.1093/jsxmed/qdaf102

Mohammad Yazdan Panah, Soroush Oraee, Mehra Fekri, Parsa Saberian, Sahra Afshin, Saeed Vaheb, Vahid Shaygannejad, Omid Mirmosayyeb

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引用次数: 0

Abstract

Introduction: Sexual dysfunction is prevalent in people with multiple sclerosis (PwMS) and considerably affects their quality of life. Although sexual function (SF) is crucial in PwMS, its relationship with other characteristics remains insufficiently understood.

Objective: This review aimed to consolidate the evidence comparing SF between PwMS and healthy controls (HCs) and to explore its correlation with various demographic, clinical, and psychological factors.

Methods: The PubMed/MEDLINE, Embase, Scopus, and Web of Science databases were systematically searched up to July 28, 2024, to identify studies comparing SF between PwMS and HCs or assess its correlation with various demographic, clinical, and psychological characteristics. Random effects models were used in R software version 4.4.0 to estimate the pooled standardized mean difference (SMD) and pooled correlations, with their 95% CIs as the effect size metrics.

Results: In this review, 61 studies comprising 16 266 PwMS were included. The meta-analysis indicated that SF was significantly reduced in PwMS compared to HCs, with females with MS (FwMS) showing lower Female Sexual Function Index scores (SMD: -0.41, 95% CI, -0.61 to -0.20, P < .0001) and males with MS (MwMS) demonstrating reduced International Index of Erectile Function scores (SMD: -0.77, 95% CI, -1.32 to -0.22, P < .01). Correlation analyses highlighted associations between reduced SF and higher Expanded Disability Status Scale (EDSS), longer disease duration, and depression in gender-aggregated analyses. Reduced SF was also found to correlate with older age, higher EDSS scores, depression, and fatigue in FwMS.

Conclusion: The findings of the included studies indicated that SF is lower in PwMS compared to HCs and is influenced by age, disease duration, depression, and the EDSS. Further studies on the effects of comorbidities, medications, and MS classification on the SF of PwMS are warranted.

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多发性硬化症患者的性功能：系统回顾和荟萃分析。

简介：性功能障碍在多发性硬化症（PwMS）患者中很普遍，并严重影响他们的生活质量。虽然性功能（SF）在PwMS中是至关重要的，但其与其他特征的关系仍未得到充分的了解。目的：本综述旨在巩固PwMS与健康对照（hc）之间SF的比较证据，并探讨其与各种人口统计学、临床和心理因素的相关性。方法：系统检索截至2024年7月28日的PubMed/MEDLINE、Embase、Scopus和Web of Science数据库，以确定比较PwMS和hc之间SF的研究，或评估其与各种人口统计学、临床和心理特征的相关性。采用R软件4.4.0版本中的随机效应模型估计合并标准化平均差（SMD）和合并相关性，并以其95% ci作为效应大小指标。结果：在本综述中，纳入了61项研究，包括16266个PwMS。荟萃分析显示，与hc相比，PwMS患者的SF显著降低，女性MS患者（FwMS）的女性性功能指数评分（SMD: -0.41, 95% CI, -0.61至-0.20，P）较低。结论：纳入的研究结果表明，PwMS患者的SF较hc患者低，且受年龄、病程、抑郁和EDSS的影响。需要进一步研究合并症、药物和MS分类对PwMS SF的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Sexual Medicine 医学-泌尿学与肾脏学

CiteScore

6.20

自引率

5.70%

发文量

826

审稿时长

2-4 weeks

期刊介绍： The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research. The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine. The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.