Journal of Sexual Medicine最新文献

{"title":"What is the right approach for Peyronie's disease surgery? Comparing postoperative wound complications between ventral and subcoronal incisions with penile straightening surgery.","authors":"Amanda Seyer, Javier Piraino, Andres Guillen Lozoya, Matthew Ziegelmann","doi":"10.1093/jsxmed/qdaf189","DOIUrl":"10.1093/jsxmed/qdaf189","url":null,"abstract":"<p><strong>Background: </strong>Multiple guideline-based surgical treatment options for Peyronie's disease (PD) exist, including penile plication and plaque incision or excision and grafting. Surgical incision type may differ depending upon location and severity of curve, planned concomitant procedures, and surgeon preference.</p><p><strong>Aim: </strong>To evaluate postoperative wound complications comparing outcomes between ventral and subcoronal incisions in patients undergoing tunica albuginea plication (TAP) and plaque incision or partial excision and grafting (PG) for PD.</p><p><strong>Methods: </strong>A single-surgeon, single-center retrospective chart review was conducted on all patients undergoing TAP or PG from 2019 to 2023. Patient demographics, including previous PD treatments, were recorded. A Mann-Whitney U test was utilized to determine differences in wound complication rate, median curvature improvement, and remaining postoperative curvature between ventral and subcoronal approaches.</p><p><strong>Outcomes: </strong>Wound complication was classified as any dehiscence and/or wound exudate suspicious for infection within the first 3 months postoperatively. A secondary analysis was performed comparing these outcomes between TAP and PG.</p><p><strong>Results: </strong>In the analysis, 189 patients were included, including PD straightening surgery, including 125 patients who underwent TAP (66%) and 64 patients (34%) who underwent PG. Among all cases, 49.7% underwent ventral incision (N = 94) and 50.3% (N = 95) underwent subcoronal incision. A total of 12 patients (6.3%) experienced a wound-related complication postoperatively (range 3-23 days), including 9/94 (9.6%) in the ventral incision cohort and 3/95 (3.2%) in the subcoronal cohort (P = 0.081). All the patients were treated with oral antibiotics and two patients required closure under local anesthesia (both in the ventral incision cohort). Secondary analysis did not reveal any significant difference in outcomes between TAP and PG cohorts with respect to wound complications.</p><p><strong>Clinical implications: </strong>While we did not identify a statistically significant difference, most of our wound complications, including infection and/or dehiscence, were seen in those undergoing a ventral penile raphe incision. Despite this, the rate of wound complications with either incisional approach as low.</p><p><strong>Strengths and limitations: </strong>Our report represents a large cohort of patients treated with surgical straightening for PD, and to our knowledge is one of the first to compare wound complications between ventral and subcoronal incisions. Limitations include the retrospective single-surgeon series without randomization, lack of power analysis, and heterogenous classification of wound complications.</p><p><strong>Conclusion: </strong>Both ventral penile raphe and subcoronal (degloving) incisions can be considered for penile straightening procedures to correct PD curv","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1863-1870"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol-induced priapism: a rare occurrence with severe outcomes.","authors":"Carolina Baz, Helen Prevas, Christopher Graziano, David W McDermott","doi":"10.1093/jsxmed/qdaf195","DOIUrl":"10.1093/jsxmed/qdaf195","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1810-1811"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does dietary supplementation with polyunsaturated fatty acids really help prevent erectile dysfunction? Findings from a mixed-exposure analysis.","authors":"Shengyi Chen, Yuekun Fang, Yao Liu, Bin Cheng","doi":"10.1093/jsxmed/qdaf212","DOIUrl":"10.1093/jsxmed/qdaf212","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1762-1763"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with improved curvature outcomes with collagenase clostridium histolyticum for Peyronie's disease: results from a large prospective series.","authors":"Ellen M Cahill, Landon Trost","doi":"10.1093/jsxmed/qdaf213","DOIUrl":"10.1093/jsxmed/qdaf213","url":null,"abstract":"<p><strong>Background: </strong>Since its release in 2014, collagenase clostridium histolyticum (CCH) has become the most commonly used injectable therapy for Peyronie's disease (PD). While some studies have suggested modest improvements in curvature with use of CCH, others have found more significant gains.</p><p><strong>Aim: </strong>To determine predictors of improved curvature in men with PD treated with CCH.</p><p><strong>Methods: </strong>A prospective, sequential database has been maintained of all men with PD undergoing CCH injections since 2014. Clinical characteristics and responses to standardized and nonstandardized questionnaires were collected at baseline, during, and after treatment.</p><p><strong>Outcomes: </strong>Change in curvature was assessed using the \"Most Recent\" curvature assessment, and statistical analyses were performed to identify factors that correlated with greater curve improvements.</p><p><strong>Results: </strong>A total of 826 men underwent at least one CCH series and comprise the current cohort. Univariate analysis demonstrated associations between greater curvature improvements in patients with more severe baseline curvature (0.5° greater improvement per increase in 1° baseline), hourglass deformities (3-10° greater improvement among moderate/severe men), number of CCH series administered (0-4° per series), strong nocturnal erections (11° higher), greater frequency of intercourse (0.6° per intercourse attempt per month), greater bother and psychological impact (as assessed by the Peyronie's Disease Questionnaire), and those who used RestoreX (5-20° depending on test). Worse outcomes were observed among men who self-reported decreased motivation (7°) as well as those with pure lateral curvatures (11°). Men who experienced hematomas, a popping sensation, and those with rapid detumescence during treatment also had more significant improvements in curvature (5°). On multivariate analysis, baseline curvature, lateral curve direction, hourglass/indentation deformities, RestoreX use, and suspected controlled penile fracture remained independently associated with better outcomes. Of all the factors assessed, RestoreX use was associated with the largest degree of improvement.</p><p><strong>Clinical implications: </strong>These findings highlight several potential predictors of improved outcomes with CCH, which may be utilized by providers to help counsel patients deciding on medical versus surgical treatment of PD.</p><p><strong>Strengths and limitations: </strong>The strengths include the largest single-center prospective database of PD patients undergoing CCH published to date and use of objective and validated instruments to track PD outcomes. Limitations include the single-center nature, diverse patient cohort, and change in CCH technique over time.</p><p><strong>Conclusion: </strong>Several baseline and treatment-related factors correlate with CCH outcomes. These data may assist both patients and providers as they","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1799-1807"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health in war zones: time for culturally sensitive clinical preparedness.","authors":"Stephanie Zakhour, Aline Sardinha, Antonio E Nardi","doi":"10.1093/jsxmed/qdaf201","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf201","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 10","pages":"1812-1813"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort.","authors":"Samantha Schildroth, Julia Bond, Amelia K Wesselink, Martha R Koenig, Antonia M Calafat, Julianne Cook Botelho, Jasmine Abrams, Lauren A Wise","doi":"10.1093/jsxmed/qdaf205","DOIUrl":"10.1093/jsxmed/qdaf205","url":null,"abstract":"<p><strong>Background: </strong>Phthalates are endocrine-disrupting chemicals that can dysregulate hormonal systems supporting female sexual function (eg, estrogen interference). Female sexual function is important for positive sexual expression, fertility, and well-being but remains understudied in the context of environmental toxicants to which females are ubiquitously exposed. Identifying environmental determinants of female sexual dysfunction can inform exposure-reduction strategies and clinical practice to improve sexual health.</p><p><strong>Aim: </strong>We investigated associations between phthalate exposure and sexual function in a cohort of North American females.</p><p><strong>Methods: </strong>We leveraged cross-sectional data from a subset of 21-45-year-old females trying to conceive enrolled in Pregnancy Study Online (n = 347) to assess associations between phthalate and phthalate alternative exposure and sexual function, measured on a modified version of the Female Sexual Function Index-6 (FSFI-6). We summed FSFI-6 responses (range = 2-30); lower scores reflected poorer function. We measured urinary concentrations of 18 phthalate and alternative metabolites using online solid phase extraction coupled with high-performance liquid chromatography isotope dilution tandem mass spectrometry. Given that the biomarkers were nonlinearly associated with FSFI-6 scores, we categorized creatinine-corrected biomarker concentrations in tertiles. We used multivariable linear regression to estimate mean differences (β) with 95% confidence intervals (CIs) in FSFI-6 scores per tertile increase in biomarker concentrations, adjusting for hypothesized confounders. In secondary analyses, we considered individual FSFI-6 items (range = 1-5) as outcome variables.</p><p><strong>Outcomes: </strong>Female sexual function measured on the FSFI-6.</p><p><strong>Results: </strong>Most biomarkers were not associated with FSFI-6 scores. Mono-n-butyl phthalate concentrations were weakly and non-monotonically associated with lower summed FSFI-6 scores (β = -0.8, 95% CI = -1.8, 0.2) and orgasm scores (β = -0.3, 95% CI = -0.7, 0.1) at the second (vs first) tertile, reflecting poorer sexual function. Mono-2-ethyl-5-carboxypentyl terephthalate concentrations were weakly associated with poorer scores for orgasm, while other biomarkers (notably, mono-carboxyisononyl phthalate) were associated with higher summed FSFI-6 and FSFI-6 item scores.</p><p><strong>Clinical implications: </strong>Exposure to phthalates should be considered in clinical settings, particularly for females experiencing issues with sexual function.</p><p><strong>Strengths and limitations: </strong>This study represents one of the first to assess associations of phthalate exposure and female sexual function, and we investigated associations in an established cohort with a validated measure of sexual function. We were limited by our sample size and cross-sectional study design.</p><p><strong>Conclusion: </s","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1766-1779"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diamond tip dermabrasion in the treatment of hyperpigmentation of the female intimate region: a cross-over controlled trial.","authors":"Isadora Victorino da Silva Amatto, Daniele Cristovam Nunes, Luana Bernardes Perri, Marília Fernandes Andrade, Thais de Castro Santos, Simone Botelho, Ligia de Sousa Marino","doi":"10.1093/jsxmed/qdaf186","DOIUrl":"10.1093/jsxmed/qdaf186","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1780-1782"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceramide test in patients with erectile dysfunction to assess cardiovascular risk.","authors":"Andres Guillen Lozoya, Mihai Dumbrava, Milad Bonakdarhashemi, Jayson Kemble, Sevann Helo, Matthew Ziegelmann, Scott Collins, Vlad Vasile, Stephen Kopecky, Tobias Köhler","doi":"10.1093/jsxmed/qdaf182","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf182","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a known precursor and sequela of cardiovascular disease (CVD), with ED severity predicting CVD severity.</p><p><strong>Aim: </strong>This study aimed to evaluate the utility of ceramide levels in patients with ED.</p><p><strong>Methods: </strong>We initiated ceramide testing in all patients with ED. We retrospectively analyzed ceramide levels from electronic records and stratified by severity of symptoms using the erectile function domain of the International Index of Erectile Function (IIEF).</p><p><strong>Outcomes: </strong>The study aimed to determine whether abnormal ceramide levels were associated with ED severity and increased cardiovascular risk.</p><p><strong>Results: </strong>Three hundred and fifty-four patients were reviewed, of whom 253 (71.5%) had moderate or higher ED. A statistically significant difference in abnormal ceramide values was found in patients with moderate to severe symptoms, and the odds of getting an abnormal ceramide test were increased based on the IIEF scoring alone (odds ratio [OR] 2.3 [1.04-5.12]; P-value = .034).</p><p><strong>Clinical implications: </strong>Serum ceramide testing could be beneficial in identifying cardiovascular risk in men with ED, potentially prompting cardiac referrals and lifestyle modifications.</p><p><strong>Strengths and limitations: </strong>The strengths of this study include a large sample size and the use of a well-established scale, while the limitations include the retrospective nature of the study and the need for further research to validate the findings.</p><p><strong>Conclusion: </strong>Patients undergoing management for ED may benefit from serum ceramide testing and subsequent cardiac referral.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":"22 10","pages":"1750-1756"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new mini-invasive surgical treatment for Peyronie's disease: mechanically processed lipoaspirates as regenerative therapy.","authors":"Elisa Berdondini, Maiolino Giuseppe, Andrea Margara, Patrizio Rigatti, Salvatore Voce, Giulio Reale, Carlo Saltutti, Marco Maroccia, Juan Ignacio Martínez-Salamanca, Mauro Gacci, Pier Andrea Della Camera, Lorenzo Tosco, Ahmed Eissa, Angelo Trivisonno, Nicola Mondaini, Carlo Bettocchi, Mauro Silvani","doi":"10.1093/jsxmed/qdaf196","DOIUrl":"10.1093/jsxmed/qdaf196","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1860-1862"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of marital status and age on changes in sexual function in women with severe obesity after bariatric surgery.","authors":"Jaime Ruiz-Tovar, Gilberto Gonzalez, Maria-de-Lourdes Bolaños, Deisi-Yanira Ramírez-Zárate, Nuria-María De-Castro, Carolina Llavero","doi":"10.1093/jsxmed/qdaf207","DOIUrl":"10.1093/jsxmed/qdaf207","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1783-1784"},"PeriodicalIF":3.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}