Journal of Sexual Medicine最新文献

{"title":"Intimacy and sexual well-being in couples coping with sexual interest/arousal disorder: the importance of perceived partner responsiveness.","authors":"Delphine Perrier Léonard, Natalie O Rosen, Noémie Bigras, Maude Massé-Pfister, Sophie Bergeron","doi":"10.1093/jsxmed/qdaf119","DOIUrl":"10.1093/jsxmed/qdaf119","url":null,"abstract":"<p><strong>Background: </strong>Sexual Interest/Arousal Disorder (SIAD) is one of the most common sexual issues reported by women and a leading reason for seeking sex and couple therapy-yet is rarely studied from a dyadic perspective. Intimacy is one interpersonal factor that could promote greater sexual well-being in individuals with SIAD and their partners.</p><p><strong>Aim: </strong>Using a dyadic cross-sectional design, this study examined the associations between the three components of intimacy (self-disclosure, perceived partner disclosure, and perceived partner responsiveness) and sexual satisfaction, sexual distress and sexual function among 263 couples coping with SIAD. The moderating role of couple type (cisgender heterosexual vs sexual/gender diverse) was also assessed.</p><p><strong>Method: </strong>263 individuals with SIAD (Mage = 34.16) and their partners (Mage = 35.71) completed validated questionnaires through the secure online survey platform Qualtrics.</p><p><strong>Outcomes: </strong>Outcomes were The Global Measure of Sexual Satisfaction; The Sexual Distress Scale and the Sexual Function Evaluation Questionnaire.</p><p><strong>Results: </strong>Results showed that when partners of individuals with SIAD perceived greater responsiveness from the individual with SIAD, it was associated with their own higher sexual satisfaction and sexual function, and lower sexual distress, as well as with the individual with SIAD's greater sexual satisfaction. Additionally, in sexual/gender-diverse relationships, individuals with SIAD who perceived greater partner responsiveness reported better sexual function. In cisgender heterosexual relationships, when partners perceived higher responsiveness from individuals with SIAD, this was also linked to the individual with SIAD's greater sexual function. However, self-disclosure and perceived partner disclosure were not associated with sexual well-being in the couple.</p><p><strong>Clinical implications: </strong>Enhancing feelings of closeness and connection through clinical interventions focusing on perceived partner responsiveness could help couples with SIAD better cope with the sexual challenges of SIAD.</p><p><strong>Strengths & limitations: </strong>Strengths of this study include the large and diverse clinical sample of couples coping with SIAD, the dyadic design, and the use of moderation to examine the role of couple type in the associations between intimacy and sexual well-being. However, the cross-sectional design limits our ability to establish causation, and the interpretation of results should consider the reliance on self-report questionnaires.</p><p><strong>Conclusion: </strong>Findings underscore the importance of understanding interpersonal dynamics in SIAD, highlighting the potential positive impact of perceived partner responsiveness on sexual well-being for individual with SIAD and their partners. The moderating effects of couple type on the individuals with SIAD's sexual func","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1093-1105"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatments for postorgasmic illness syndrome: a systematic review.","authors":"Sarah Ponce, Meghana Chapalamadugu, Samantha Levine, Cameron Stokes, Karla Radillo, Olivia Johnson, Isaac Bronson, Rachel S Rubin","doi":"10.1093/jsxmed/qdaf112","DOIUrl":"10.1093/jsxmed/qdaf112","url":null,"abstract":"<p><strong>Introduction: </strong>Postorgasmic illness syndrome (POIS) is a rare, poorly understood condition that is characterized by feeling ill after orgasm. Despite its significant impact on quality of life, POIS remains poorly understood, and effective treatment options are limited without clear guidelines. Only 18% of sexual medicine experts report symptom improvement in more than 30% of the patients. Current treatments have been used to address the various presentations such as flu-like state, mood disturbances and/or irritability, as well as congestion and inflammation. Given the lack of standardized therapeutic approaches, there is a critical need to document and evaluate various treatments tried for POIS management.</p><p><strong>Objective: </strong>This systematic review aims to evaluate current treatment modalities for POIS and compile solutions that have been studied and tested.</p><p><strong>Methods: </strong>A search was conducted in June 2024 of 3 of the most relevant databases (PubMed, Embase, and Scopus) of clinical studies, randomized controlled trials, and case reports analyzing treatment modalities of patients with diagnosed POIS.</p><p><strong>Results: </strong>Of 58 studies found, 14 matched our inclusion criteria. Our systematic review consists of 1 cross-sectional study, 1 cohort study, and 12 case reports. Two papers included female patients, and the rest studied only male patients. Eleven papers discussed pharmacologic treatment modalities, including antihistamines, ibuprofen, NSAIDs, hormone replacement therapy, steroids, SSRIs, alpha-blockers, beta-blockers, calcium channel blockers, and triptans. Two papers mentioned immune treatment, one being the intracutaneous injection of autologous semen and the other being intralymphatic immunotherapy with the injection of allergen-specific immunotherapy. One paper mentioned surgical treatment with bilateral epididymectomy and bilateral vasoligation.</p><p><strong>Conclusion: </strong>The largest limitation to continued research is related to the rarity and low recognizability of POIS; however, POIS research is on the rise. Scientists across the world are collaborating to better understand the pathophysiology behind this condition and investigate treatment modalities to address the associated symptoms.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1236-1243"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual desire in women with fibromyalgia: beyond the pain?","authors":"Ana M Cuevas-Toro, Carmen Díaz-Batanero, María Del Mar Sánchez-Fuentes","doi":"10.1093/jsxmed/qdaf123","DOIUrl":"10.1093/jsxmed/qdaf123","url":null,"abstract":"<p><strong>Background: </strong>Women with fibromyalgia often experience sexual dysfunction, particularly reduced sexual desire, but few studies have used specific measures, such as the Sexual Desire Inventory, to assess this, and the predictors of sexual desire in these women remain unclear.</p><p><strong>Aim: </strong>This study aimed to analyze sexual desire in Spanish women diagnosed with fibromyalgia (fibromyalgia group, FG) and in a control group (CG) of healthy women and to examine the predictors (age, symptoms duration, time since diagnosis, severity of fibromyalgia, antidepressant drugs, depressive symptoms and anxiety symptoms) of sexual desire in the FG.</p><p><strong>Methods: </strong>The sample consisted of 81 women divided into 2 groups FG (n = 46) and CG (n = 35). The average age was 47.23 years (SD = 9.22) for the FG and 46.14 years (SD = 9.52) for the CG.</p><p><strong>Outcomes: </strong>The main outcome measures were sexual desire, as assessed through the Sexual Desire Inventory, severity of fibromyalgia (Fibromyalgia Impact Questionnaire) and anxiety and depression (Hospital Anxiety and Depression Scale).</p><p><strong>Results: </strong>Women in the FG had lower sexual desire than those in the CG. Age, time since diagnosis, and depression were associated with different dimensions of sexual desire. In contrast, fibromyalgia severity, anxiety, and months using SSRIs were not linked to any dimensions of sexual desire. Hierarchical multiple regression analysis revealed that age, time since of FM diagnosis, and depression predicted global sexual desire, accounting for 30% of its variance.</p><p><strong>Clinical implications: </strong>Assessing sexual desire and addressing depressive symptoms early in women with fibromyalgia is essential for improving their sexual health.</p><p><strong>Strengths and limitations: </strong>This is the first study to assess different dimensions of sexual desire, including sexual desire for an attractive person, while simultaneously examining key factors associated with sexual desire in women with fibromyalgia. However, the sample size is relatively small, and the study lacks a longitudinal design.</p><p><strong>Conclusion: </strong>Women with FG have lower sexual desire than healthy women, primarily due to age, time since diagnosis, and depressive symptoms.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1106-1114"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic floor muscle activation in response to pressure stimuli applied to the vulvar vestibule: an observational study comparing women with and without provoked vestibulodynia.","authors":"Linda McLean, Flavia Ignacio Antonio, Marina Petter Rodrigues, Caroline Pukall","doi":"10.1093/jsxmed/qdae171","DOIUrl":"10.1093/jsxmed/qdae171","url":null,"abstract":"<p><strong>Background: </strong>The nature of pelvic floor muscle (PFM) involvement in provoked vestibulodynia (PVD) is poorly understood.</p><p><strong>Aim: </strong>We aimed to determine if PFM electromyographic (EMG) activity in anticipation of or response to pressure applied to the posterior vaginal fourchette differs between those with and without PVD, and if the magnitude of PFM response is associated with pressure pain sensitivity, psychological or psychosexual function.</p><p><strong>Methods: </strong>This was an observational case-control study. Forty-two volunteers with PVD and 43 controls with no vulvar pain participated. Five on-line questionnaires were completed, then participants underwent a laboratory-based evaluation of vulvar pain sensitivity. EMG activation of the PFMs, hip adductor, and upper trapezius muscles was measured before, during, and after pressure stimuli (low, moderate) were applied, in random order, to the posterior vaginal fourchette and the posterior thigh (control site).</p><p><strong>Outcomes: </strong>EMG amplitude of the pubovisceralis (PV), bulbocavernosus (BC), and external anal sphincter (EAS) muscles. Secondary outcomes were EMG activation of the hip adductor brevis and upper trapezius muscles, questionnaire scores reflecting psychological/psychosexual outcomes, pressure pain threshold (PPT) at the vulvar vestibule, pain reported on a tampon test, and heart rate/heart rate variability.</p><p><strong>Results: </strong>Compared to controls, EMG activation of the PV and EAS, but not the BC, was higher in anticipation of the pressure applied to the vaginal fourchette, was higher in all PFMs while the pressure was applied, and remained higher than baseline after the pressure was removed among those with PVD. EMG response amplitudes were modulated by the intensity of the pressure applied, with the largest responses reaching over 40% MVC in the EAS among those with PVD. PFM EMG amplitudes were associated with greater pain sensitivity and lower sexual function, but not with pain catastrophizing, central sensitization, depression, anxiety, or stress.</p><p><strong>Clinical implications: </strong>While some anticipatory activation was observed, EMG responses were primarily observed during and after the application of the pressure. Among those with PVD, digital assessment of PFM tone might reflect PFM responses to pain at the vulvar vestibule, and interventions to reduce local pain sensitivity may be an important first step to successful improvements in vaginal function.</p><p><strong>Strengths and limitations: </strong>This study includes a robust analysis of EMG activation. However, the cross-sectional design precludes the determination of causal relationships.</p><p><strong>Conclusions: </strong>Those with PVD demonstrate higher PFM responses and a higher prevalence of anticipatory activation in the PV and EAS muscles than controls in response to pressure applied at the vulvar vestibule.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1158-1172"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors shaping sexual abstinence among adolescents and young adults: a systematic review.","authors":"Laoungang Ange Maïn-Ndeiang, Gustave Soh, André Wamba","doi":"10.1093/jsxmed/qdaf146","DOIUrl":"https://doi.org/10.1093/jsxmed/qdaf146","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Sexual abstinence is considered as a reproductive health-promoting behavior in adolescents and young adults to prevent negative sexual outcomes, such as sexually transmitted infections, and unintended pregnancies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;To review the prevalence and factors related to sexual abstinence in adolescents and young adults aged between 10 and 24 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Studies were retrieved from Google Scholar, ResearchGate, PubMed, and Journal of Storage (JSTOR). The selection criteria were original population-based studies, published in the English or French language, on either sexual abstinence (primary and/or secondary abstinence) or intention to abstain, and in adolescents and/or young adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;This study reviewed the literature on the prevalence of, motivations for and factors associated with abstinent behavior in adolescents and young adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;1989 studies were retrieved, from which data were extracted for 55 studies. The overall prevalence ranged from 1.6% to 100%. The prevalence of primary sexual abstinence ranged from 22.1% to 100%; secondary sexual abstinence from 1.6% to 68.1%; and sexual abstinence intention from 50% to 73.8%. The significant factors reported were age, gender, educational level, socioeconomic status, religion, relationship status, sex education, HIV knowledge, not using alcohol, positive attitudes towards sexual abstinence, perceived risk of sexual intercourse, positive peer influence, social norms related to sexual abstinence, aspirations for the future, higher self-efficacy in sexual abstinence, and sexual communication. In addition, the review revealed various motives, such as religious beliefs, perceived physical and psychological consequences of sexual activities, perceived social benefits of sexual abstinence, and aspirations for a better life were related to young people's abstinent behavior. Although the variations in findings from different studies can be explained by differences in regions, cultures, and research design and methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;The studies on sexual abstinence in the future should use a consistent and standard definition, cover the multidimensionality of sexual behavior, and examine all related factors and motivations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths & limitations: &lt;/strong&gt;The restricted timeframe (1998-2023), English/French language, availability of full text, and measurement of abstinent behavior may be the sources of bias.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The prevalence of sexually abstinent adolescents and young adults varies greatly across studies and was associated with a range of factors and motivations/barriers. Although factors and motivations/barriers were identified, further investigation is needed on the secondary sexual abstinence and the multidimensionality of sexual abstinence rather than simple abstinence f","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexuality among the elderly: a prospective cohort study in primary care.","authors":"Mathilde Baumhauer, Laurent Becquemont, Henri Panjo, Virginie Ringa, Sophie Bucher","doi":"10.1093/jsxmed/qdaf121","DOIUrl":"10.1093/jsxmed/qdaf121","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1301-1302"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of older married women's sexual satisfaction: the mediating role of intimacy.","authors":"Roghie Bagheri, Yadollah Abolfathi Momtaz, Mahshid Foroughan, Farahnaz Mohammadi Shahboulaghi","doi":"10.1093/jsxmed/qdaf104","DOIUrl":"10.1093/jsxmed/qdaf104","url":null,"abstract":"<p><strong>Background: </strong>Sexuality is an essential dimension of health in older adults that is often overlooked. Several factors are known to affect sexual satisfaction. Studies have focused on the role of interpersonal processes, such as intimacy, in sexual satisfaction with aging. However, the mediating role of intimacy among determinants of older women's sexual satisfaction was absent in prior studies.</p><p><strong>Aim: </strong>The present study aimed to determine the factors affecting sexual satisfaction of older married women. Additionally, it investigates the mediating role of intimacy in the relationship between several determinants of sexual satisfaction of older married women.</p><p><strong>Methods: </strong>In this cross-sectional study, 418 older married women from Tehran were selected using multi-stage random sampling. Questionnaires were completed through individual interviews with the participants. IBM SPSS 25 and AMOS version 24 were employed to assess the determinants of sexual satisfaction.</p><p><strong>Outcomes: </strong>Sexual satisfaction and its indicators were assessed by using the Global Measure of Sexual Satisfaction, Female Sexual Function Index (FSFI), Short Form-8 Health Survey (SF-8), and questions made by researchers.</p><p><strong>Results: </strong>Among 418 participants aged 60-80 years old, the sexual satisfaction score was 21.78 ± 7.94. Based on the multiple linear regression model, the strongest determinants of sexual satisfaction were sexual functioning (β = .26, P < .001) and the importance of sexuality (β = .28, P < .001). The result of the structural equational model showed that intimacy mediates the link between several determinants and sexual satisfaction (CMIN = 3.49; CFI = 0.98; RMSEA = 0.07).</p><p><strong>Clinical implications: </strong>Policies and programs in the field of sexual health should acknowledge the existence of sexual needs in the post-reproductive years and support the promotion of sexual satisfaction in old age, considering the factors affecting it.</p><p><strong>Strengths and limitations: </strong>The present study attempted to clarify knowledge in the field of sexual health of older women by examining several determinants of sexual satisfaction, using valid questionnaires, and presenting a model that assessed several determinants. The sample was representative of the older married women population from different areas of Tehran. However, sampling from the community level and only from married older women does not provide a perspective concerning older adults without spouses or residents of care institutions.</p><p><strong>Conclusion: </strong>Several variables at different levels directly or through intimacy are effective on the sexual satisfaction of older married women, so interventions that can promote intimacy between couples can be associated with improvement in the sexual satisfaction of older adults.</p>","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1216-1225"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Patient-reported outcome measures (PROMs) used to assess sexual functioning in prostate cancer patients: a systematic review of psychometric properties.","authors":"","doi":"10.1093/jsxmed/qdaf129","DOIUrl":"10.1093/jsxmed/qdaf129","url":null,"abstract":"","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1308"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for self-management of painful intercourse among female pregnancy planners.","authors":"Julia C Bond, Samantha Schildroth, Katharine O White, Rebecca Fisher, Caroline F Pukall, Jasmine Abrams, Lauren A Wise","doi":"10.1093/jsxmed/qdaf100","DOIUrl":"10.1093/jsxmed/qdaf100","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Despite the fact that painful intercourse is common among reproductive-aged females, little research has evaluated how people manage painful intercourse while trying to conceive.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To characterize the self-reported frequency and effectiveness of various self-management strategies among a population of pregnancy planners reporting painful intercourse in the past 4 weeks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We used cross-sectional data from Pregnancy Study Online, an online preconception cohort study of pregnancy planners. Female-identified participants completed a baseline questionnaire that included questions about demographic, medical, and reproductive factors. Participants additionally completed an optional questionnaire asking about sexual function. We used a single question from the Female Sexual Function Index to evaluate painful intercourse: \"Over the past 4 weeks, how often did you experience discomfort or pain during vaginal penetration (intercourse)?,\" with responses captured on a Likert scale from \"Almost never or never\" to \"Almost always or always.\" Those who reported pain more frequently than \"Almost never or never\" were categorized as experiencing \"any pain\" with intercourse and completed additional questions about how they mitigated it. For each endorsed strategy, participants ranked how effective it was at improving pain on a Likert scale from \"Never effective\" to \"Always effective.\" For analyses, we grouped \"often\" and \"always\" effective into a single category. We described the reported effectiveness of self-management strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The prevalence of participants reporting a strategy as being \"often\" or \"always\" effective at improving pain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In our sample of 2855 pregnancy planners, 855 (30.7%) reported any painful intercourse in the past 4 weeks. The most commonly tried pain management strategy was trying a different sex position (66.6% of participants), while the least common strategy was not allowing full penetration of the penis (29.9%). Lubricant was most effective, with 74.3% of participants reporting that it was \"often or always\" effective. The least effective strategy was finishing intercourse quickly, with only 32.5% of attempters reporting it was \"often or always\" effective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Providers should be aware of strategies to improve painful intercourse to aid in patient counseling, both in the preconception period and more broadly when pursuing the diagnosis of, and medical management strategies for, dyspareunia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Large geographic heterogeneity and low data missingness. Limitations include potential for misclassification and the use of non-validated self-report measures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In a population of females trying to conceive, lubricant use and changing sex positions were frequently reported as \"o","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1173-1183"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone morphogenetic protein 2 rescues neurogenic abnormalities and angiogenic factors in mice with bilateral cavernous nerve injury.","authors":"Jong Won Kim, Doo Yong Chung, Fang-Yuan Liu, Yan Huang, Fitri Rahma Fridayana, Minh Nhat Vo, Kang Su Cho, Ji-Kan Ryu, Mi-Hye Kwon, Guo Nan Yin","doi":"10.1093/jsxmed/qdaf091","DOIUrl":"10.1093/jsxmed/qdaf091","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bone morphogenetic protein 2 (BMP2), a key isoform within the bone morphogenetic protein family, plays a critical role in promoting angiogenesis and peripheral nerve regeneration, but its specific role in neurogenic erectile dysfunction (ED) remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aimed to explore the therapeutic efficacy of exogenous recombinant BMP2 protein administration in restoring erectile function in a mouse model of cavernous nerve injury (CNI)-induced ED.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twelve-week-old male C57BL/6 mice were used to evaluate BMP2 expression and erectile function following CNI. Western blotting and immunofluorescence staining were employed to assess BMP2 levels in corpus cavernosum tissues from both sham-operated and CNI-induced ED mice. Erectile function was measured through electrical stimulation of bilateral cavernous nerves, with subsequent intracavernous pressure parameter recordings. Mechanistic investigations included immunofluorescence staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, and western blot analysis. Additionally, ex vivo neurite outgrowth assays were conducted using dorsal root ganglia (DRG) and major pelvic ganglia (MPG) tissues.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;In vivo intracavernous pressure, neurovascular regeneration, proliferation, apoptosis, ex vivo neurite sprouting, and survival signaling were measured.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Bone morphogenetic protein 2 expression was significantly decreased in the corpus cavernosum of CNI mice. Exogenous administration of recombinant BMP2 protein effectively enhanced erectile function in CNI mice, likely through the restoration of endothelial cells, smooth muscle cells, pericytes, and neuronal cells within the corpus cavernosum. Immunofluorescence staining and western blot analysis demonstrated that BMP2 treatment promoted angiogenesis by increasing endothelial cell proliferation and reducing apoptosis in the corpus cavernosum. Furthermore, ex vivo assays revealed that BMP2 promoted neurite sprouting in DRG and MPG tissues exposed to lipopolysaccharide. Mechanistic studies further indicated that BMP2 increased the expression of neurotrophic factors and VEGF, activating the AKT/eNOS signaling pathway.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Bone morphogenetic protein 2 may be used as a strategy to treat neurogenic ED or other neurovascular diseases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Bone morphogenetic protein 2 has dual roles in vascular and neuronal development. Our study focused on broadly evaluating the role of BMP2 in neurogenic ED. Future studies will evaluate the nerve regeneration effects and novel signaling pathways of BMP2 in a sciatic nerve injury mouse model. In view of its properties as an angiogenic factor, its dose concentration should be strictly controlled to avoid potential side effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The exogenous ","PeriodicalId":51100,"journal":{"name":"Journal of Sexual Medicine","volume":" ","pages":"1083-1092"},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}