Evaluation of sexual dysfunction among women with primary Sjögren's syndrome using a Female Sexual Function Index: a systematic review and meta-analysis.
Settimio D'Andrea, Antonio Vinci, Luca Navarini, Andrea Sansone, Annalisa Marino, Dorian Bardhi, Alessandra Bruno, Francesco Rosiello, Camilla Lombardo, Edoardo Agostini, Fabio Ingravalle, Susanna Gentili, Massimo Maurici, Antonella Berardicurti, Emmanuele A Jannini, Roberto Giacomelli, Onorina Berardicurti
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Abstract
Background: Only a few studies have assessed sexual dysfunction in women with primary Sjögren's syndrome (pSS).
Aim: We aimed to confirm the higher prevalence of sexual dysfunction in these women and identify the most impaired domain of sexual function and the risk factors associated with it.
Methods: We conducted a systematic review and meta-analysis to investigate the risk of sexual dysfunction in women with pSS according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The study protocol has been registered in the "PROSPERO international prospective register of systematic reviews" with the registration number CRD42022298525.
Outcomes: We aimed to compare sexual dysfunction among women with pSS compared to healthy subjects and which domain of the Female Sexual Function Index (FSFI) was most impaired.
Results: In the analysis involving 16 studies, pSS is associated with 5-fold higher odds of reporting sexual dysfunction compared to the control group. Additionally, differences in FSFI scores between pSS and healthy controls were found to be statistically significant. All FSFI item sub-scores were affected by pSS more than the control group.
Clinical implications: Sexual dysfunction is common in pSS and needs to be evaluated in all women with pSS.
Strengths and limitations: This is the first meta-analysis that emphasized that sexual dysfunction in women with pSS should be evaluated regardless vaginal dryness. Nevertheless, caution is required when interpreting results due to the poor quality of the selected studies.
Conclusion: The sexual dysfunction was a common issue in pSS with various causes and should be addressed by healthcare providers.
期刊介绍：
The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research.
The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine.
The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.
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