Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique最新文献

{"title":"Art on Prescription in individuals at risk of suicide: A pilot study.","authors":"Emma Sebti, Elodie Michel, Elia Gourguechon-Buot, Philippe Courtet","doi":"10.1016/j.encep.2026.06.001","DOIUrl":"https://doi.org/10.1016/j.encep.2026.06.001","url":null,"abstract":"<p><strong>Objectives: </strong>Mental health disorders and suicidal behaviors are a major public health issue worsened by the COVID-19 pandemic. Social prescribing initiatives such as Art on Prescription aim to integrate artistic activities into healthcare to promote well-being and reduce depressive symptoms. This pilot study aimed to assess the impact of an Art on Prescription program on individuals at risk of suicide.</p><p><strong>Methods: </strong>An AoP program was implemented in Montpellier coordinated by the Department of Emergency Psychiatry and Acute Care at Montpellier University Hospital, in partnership with MO.CO. (Montpellier Contemporain). Fifty-one adults, referred after an emergency visit for suicidal ideation or a suicide attempt, were enrolled between 2022 and 2024. The program was delivered through five successive cycles. Each participant was enrolled in one cycle only, led by an artist, and included one museum visit followed by five weekly creative sessions. Depressive symptoms (PHQ-9, Patient Health Questionnaire-9) and well-being (WEMWBS, Warwick-Edinburgh Mental Wellbeing Scale) were assessed at the end of each of the five creative sessions. Wilcoxon tests and Generalized Estimating Equations (GEE) were used for analysis.</p><p><strong>Results: </strong>Among the 29 participants with complete data from the first to the fifth creative sessions, a significant improvement in well-being was observed (mean WEMWBS increase: +2.24; P=0.02), whereas the decrease in depressive symptoms was not statistically significant (PHQ-9: -0.79; P=0.12). In the full sample (n=51), the comparison between the first and third creative sessions showed a significant decrease in depressive symptoms (-0.65; P=0.05), but a non-significant increase in well-being (+1.22; P=0.11). GEE models confirmed a significant negative association between PHQ-9 and WEMWBS scores (β=-1.1; P<0.001), with no significant effect of time or interaction.</p><p><strong>Conclusions: </strong>The Art on Prescription program appears to have a positive impact on well-being and depressive symptoms in individuals at risk of suicide. These findings support the potential value of innovative, non-pharmacological interventions as a complement to traditional psychiatric care, aligned with recovery-oriented approaches.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunisian validation of the Children's Revised Impact of Event Scale 13.","authors":"Malek Baccar, Soumaya Bourgou, Fatma Charfi","doi":"10.1016/j.encep.2026.04.013","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.013","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a common consequence of traumatic experiences in children, highlighting the need for culturally adapted screening instruments. The objective of this study was to translate and validate the self-report questionnaire, the Children's Revised Impact of Event Scale-13 (CRIES-13), into Tunisian Arabic.</p><p><strong>Methods: </strong>We conducted a cross-sectional study among children aged eight to 18 years, recruited from the Child and Adolescent Psychiatry Department of Mongi Slim Hospital between February 2024 and February 2025, who had experienced a stressful life event. Non-inclusion criteria included insufficient cognitive or linguistic abilities to complete the questionnaire. Exclusion criteria were refusal to participate and incomplete questionnaires. The CRIES-13 questionnaire was translated using the forward-backward translation method. Its psychometric properties were evaluated in terms of content validity, reliability, and construct validity. The internal structure was assessed using confirmatory factor analysis. For preliminary external validation, the Tunisian version of the Clinician-Administered PTSD Scale for Children and Adolescents, Fifth Edition (CAPS-CA-5), was used.</p><p><strong>Results: </strong>A total of 300 children were included in the study. The translated version was deemed satisfactory. Internal consistency was good, with a Cronbach's alpha of 0.841. Item - subscale correlations were statistically significant and conceptually coherent. Confirmatory factor analysis supported the three-factor model and demonstrated acceptable model fit indices, as follows: χ²/df=2.78; root mean square error of approximation (RMSEA)=0.077; Standardized Root Mean Square Residual=0.092; Comparative Fit Index=0.897; Tucker-Lewis Index=0.871; Goodness-of-Fit Index=0.918; Adjusted Goodness-of-Fit Index=0.880; and Akaike Information Criterion=230. Statistically significant correlations were found between the CRIES-13 and its external validator, the Clinician-Administered PTSD Scale for Children and Adolescents, Fifth Edition (CAPS-CA-5) (r=0.897; P<0.01).</p><p><strong>Conclusion: </strong>The Tunisian Arabic version of the CRIES-13 demonstrated satisfactory psychometric properties. It can be considered a reliable and valid screening tool for PTSD among Tunisian children.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prucalopride repurposing: 5-HT₄ receptor agonists in anxiety and depression.","authors":"Salma R Abdennebi, Karen Rodriguez-Lua, Hugo Bottemanne, Emmanuelle Corruble, Denis J David, Indira Mendez-David","doi":"10.1016/j.encep.2026.06.002","DOIUrl":"https://doi.org/10.1016/j.encep.2026.06.002","url":null,"abstract":"<p><p>Major depressive disorder remains a leading cause of disability worldwide, and current antidepressant treatments are limited by a delayed onset of action, modest remission rates, and residual symptoms. Emerging evidence suggests that selective targeting of specific serotonergic receptors may offer faster and more precise therapeutic strategies. Among these targets, the serotonin type 4 (5-HT₄) receptor has gained increasing attention due to its involvement in corticolimbic circuits regulating mood, cognition, and stress responses. Preclinical studies demonstrate that 5-HT₄ receptor agonists produce rapid antidepressant- and anxiolytic-like effects, accompanied by early neuroplastic adaptations. Prucalopride, a highly selective 5-HT₄ receptor agonist approved for chronic idiopathic constipation, has recently emerged as a promising candidate for drug repurposing in psychiatry. Converging evidence from animal models, experimental human studies, and epidemiological analyses suggest that prucalopride may modulate mood-related neural circuits and cognitive processes. This perspective discusses the translational potential of 5-HT₄ receptor agonism as a novel therapeutic avenue for mood disorders.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the French version of Online Gambling Disorder Questionnaire.","authors":"Amélie Banas, Cédric Plessis, Emin Altintas","doi":"10.1016/j.encep.2026.04.007","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.007","url":null,"abstract":"<p><strong>Background: </strong>Pathological online gambling is a major public health issue, particularly among adolescents and young adults. This study aims to validate the French version of the Online Gambling Disorder Questionnaire (OGD-Q), a tool based on the DSM-5 and ICD-11 criteria, adapted to the specific characteristics of the French-speaking population.</p><p><strong>Method: </strong>Two hundred and fifty-six French-speaking participants (aged 14 to 53) were recruited online via communities dedicated to \"gacha\" games. The French version of the OGD-Q (11 items) was obtained through a rigorous translation process involving parallel translation and back-translation. Descriptive analyses were performed, as well as confirmatory factor analysis (CFA) to verify the scale's unidimensional structure, and convergent validity analyses were conducted with other tools (IGD-20 for problematic video game use, GAMS for motivation and PANAS for emotions).</p><p><strong>Results: </strong>The tool revealed an excellent internal consistency with Cronbach's alpha (0.856) and McDonald's omega (0.884) coefficients. The CFA confirmed the unidimensional structure of the scale. The fit indices were acceptable (CFI=0.927; TLI=0.908; SRMR=0.0438), although the RMSEA (0.087) was slightly above the ideal threshold. In addition, significant positive correlations were observed with the IGD-20 (r=0.383, P < 0.001) and with negative emotions during play (r=0.319, P < 0.001).</p><p><strong>Discussion: </strong>The study demonstrates that the French version of the OGD-Q has good psychometric properties, making it reliable and valid for assessing online gambling disorder in French-speaking populations. This tool fills an important gap for French-speaking clinicians and researchers enabling them to better detect and study problematic gambling behaviors related to online games, including \"gacha\" mechanics. This validation also promotes the international comparability of research on behavioral addictions.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health research in minors in France: Legal and ethical issues.","authors":"Sarah Levieux, Coralie Barbe, Anne-Catherine Rolland, Julien Eutrope","doi":"10.1016/j.encep.2026.03.021","DOIUrl":"https://doi.org/10.1016/j.encep.2026.03.021","url":null,"abstract":"<p><p>The mental health of children and adolescents is a major public health issue in France. However, there is a lack of epidemiological data on this subject. Epidemiological studies on mental health in minors are subject to numerous legal and ethical constraints. The main objective of this study was to provide an overview of epidemiological studies on the mental health of minors aged 10 to 18, conducted in France among the general population. Its secondary objective was to analyze the legal and ethical constraints governing this type of research. A literature review was conducted using the PubMed, Web of Science, and PsycInfo databases. Articles published between 2017 and 2023 were included if they reported results from epidemiological studies conducted in France among minors aged 10 to 18 in the general population, with a main objective related to mental health. Only studies in which minors were directly questioned about their mental health were included. Of the 1115 articles identified by the search strategy, 25 (corresponding to 20 separate studies) were included. In 90% of the studies, minors were interviewed anonymously. The questionnaires were administered in schools in 70% of cases. The most frequently addressed topic was psychoactive substance use (80% of studies), followed by suicidal ideation, addressed in 45% of studies. Informing legal guardians and obtaining their consent can present a barrier to minors' participation in mental health studies. The anonymization of questionnaires raises ethical questions. Epidemiological studies on the mental health of minors are constrained by strict legal and ethical requirements. Adjusting these requirements, with support from experts, could facilitate the conduct of such studies while ensuring respect for the safety and rights of minors.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When work overflows: Factors influencing work-home interaction in medical residents.","authors":"Feriel Dhouib, Omaima Errabia, Nada Kotti, Amel Kchaou, Anouare Hrairi, Mounira Hajjaji, Kaouthar Jmal Hammami","doi":"10.1016/j.encep.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.005","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to assess the factors influencing work-home interaction in medical residents and highlight the impact of burnout on this interaction.</p><p><strong>Methods: </strong>This was an analytical cross-sectional study including Tunisian medical residents during the period from September 1st, to December 31, 2022, through an online questionnaire created using Google Forms. This questionnaire included socio-demographic characteristics, occupational characteristics, Maslach Burnout Inventory (MBI) to asses Burnout, SWING scale (Survey Work-home Interaction NijmeGen) to asses work-life interaction in residents. Statistical analysis were performed using the Statistical Package for the Social Sciences SPSS. The outcome variable in our study was the score of the SWING scale among residents. For each independent variable, the score of each dimension of the SWING questionnaire was calculated. The Student's T-test was used to compare means for qualitative variables and the Pearson correlation coefficient was used to measure linear correlation for quantitative variables. The significance level was set at 5%, and differences were considered significant for P<0.05.</p><p><strong>Results: </strong>During the study period, we interviewed 140 medical residents, with a mean age of 27.1±1.8 years with a predominance of female gender (67.8%). A proportion of 84.4% of the participants were single. Most of the participants in our study were first year residents (59.3%). According to the statistical analysis, socio-demographic factors influencing work life interaction were female gender, age, depression, and engaging in leisure activity while occupational factors influencing work life interaction were working in emergency department, a number of shifts≥7 shifts/month and emotional exhaustion according to the Maslach scale.</p><p><strong>Conclusion: </strong>Appropriate corrective actions such as practicing leisure activities or restricting the number of shifts could improve work-home interaction in medical residents, and would help avoid harmful psychological and social consequences.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The debate on baclofen deserves better than trials by suspicion].","authors":"Benjamin Rolland, Laurent Karila, Nicolas Franchitto, Camille Barrault, Mickael Naassila","doi":"10.1016/j.encep.2026.04.009","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.009","url":null,"abstract":"","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Growing up with artificial intelligence: An amplifier of inequalities and a public health issue].","authors":"Théo Mouhoud, Thierry Baubet","doi":"10.1016/j.encep.2026.04.012","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.012","url":null,"abstract":"<p><p>Artificial intelligence (AI) is now an integral part of the daily lives of children and adolescents, shaping the ways in which they communicate, learn, and relate to others. Drawing on empirical research on social media and emerging data on AI, this article examines how these digital environments influence children's cognitive, relational, and emotional development. Unlike previous digital technologies, which transformed the ways in which peers interacted, conversational AI tools simulate human relationships themselves-they are constantly available, adaptive, and perceived as empathetic. While AI offers potential cognitive and educational benefits, available data show that its impact is unevenly distributed across the population. Data from ARCOM, ANCT-CRÉDOC, and the OECD indicate that children growing up in socioeconomically disadvantaged families receive less guidance in understanding digital environments and are more exposed to the cognitive, attentional, and relational risks associated with AI. Recent research in child development highlights that young people tend to attribute subjectivity and emotional understanding to AI systems, sometimes mistaking simulated responses for genuine interpersonal cues. In the absence of adequate adult mediation, artificial companions can become overly predictable relational substitutes, which may affect the development of theory of mind, symbolic functioning, and self-regulation. At the same time, the educational benefits of AI tools are more readily accessible to children from privileged backgrounds, which exacerbates preexisting social and cognitive disparities. This results in a dual digital vulnerability, in which children least equipped to navigate AI environments are also the most exposed to their risks. Currently available data on AI and the empirical literature on social media support exploring the implementation of a national digital health education program in schools, combined with targeted support for families, to ensure equitable and safe development in an increasingly algorithmic world.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social media in early psychosis and first episode: A systematic review.","authors":"Ambroise Faucher de Corn, Thomas Pedel, Pierre Bondonny, Laurent Lecardeur, Amandine Cambon, Antoine Yrondi","doi":"10.1016/j.encep.2026.04.010","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.010","url":null,"abstract":"<p><strong>Objectives: </strong>Over the past two decades social media use has expanded rapidly raising increasing concerns regarding its impact on the mental health of young and vulnerable populations. This systematic review aims to synthesize current evidence on the association between social media use and emergence of psychotic symptoms in transition processes toward psychosis.</p><p><strong>Methods: </strong>Searches were conducted in PubMed and Google Scholar databases. Of the 436 records identified, nine studies met inclusion criteria.</p><p><strong>Results: </strong>The reviewed literature highlighted a complex and heterogeneous relationship between social media use and psychosis risk. Social media exposure may function as an environmental stressor for individuals at a clinically high risk for psychosis, particularly depending on patterns of use, subjective meaning, and contextual factors. Reported mechanisms included social stress, exposure to misinformation, heightened interpersonal sensitivity, as well as potentially protective effects such as access to social support and normalization of experiences. Rather than reflecting individual deficits, vulnerability appeared to arise from dynamic interactions between social media environments and pre-existing psychological, social, and biological risk factors.</p><p><strong>Conclusions: </strong>These findings raise important questions regarding how digital social environments interact with processes of self-concept, social cognition, and stress regulation during critical developmental periods. However, conclusions remain limited by the predominance of correlational designs and the scarcity of longitudinal and qualitative research. Future studies should prioritize in-depth exploration of subjective digital experiences and longitudinal approaches to clarify causal pathways and to distinguish adaptive from stressful patterns of social media use in clinical high-risk populations.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol and executive dysfunction in adolescents with eating disorders.","authors":"Antonina Luca","doi":"10.1016/j.encep.2026.04.008","DOIUrl":"https://doi.org/10.1016/j.encep.2026.04.008","url":null,"abstract":"<p><p>Eating disorders (EDs) in adolescents, including anorexia nervosa, bulimia nervosa, and binge-eating disorder, are frequently accompanied by executive dysfunction, a set of higher-order cognitive processes governing self-regulation, planning, and decision-making. While impulsivity and poor inhibitory control predominate in bulimia nervosa and binge-eating disorder, anorexia nervosa is often characterized by cognitive rigidity and overcontrol. These contrasting neuropsychological patterns may represent distinct manifestations of executive dysfunction. Emerging evidence suggests that lipid metabolism, particularly serum cholesterol levels, may influence executive functioning, although findings in ED populations remain inconsistent. Given that cholesterol and other lipids are critical for neuronal membrane integrity, neurotransmission, and brain network function, disruptions in lipid homeostasis could contribute to specific executive functions in ED subtypes. This perspective highlights the need for targeted research linking lipid profiles to executive dysfunction within ED populations, moving beyond transdiagnostic generalizations. Understanding these relationships could inform tailored interventions that address both metabolic and neurocognitive dimensions, potentially improving long-term clinical and cognitive outcomes for adolescents with EDs.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}