Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique最新文献

{"title":"Clinical profiles, treatment adherence, and quality of life in patients with severe mental disorders treated with cyamemazine: A real-world observational study.","authors":"Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Pierre Verney, Jade Obadia, Christelle Andrieu-Haller, Antoine Lefrere, Michel Cermolacce, Guillaume Fond, Christophe Lançon, Théo Korchia","doi":"10.1016/j.encep.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.encep.2025.01.003","url":null,"abstract":"<p><strong>Background: </strong>Cyamemazine, a phenothiazine antipsychotic with anxiolytic and sedative properties, is commonly used in the management of severe mental disorders (SMDs) such as schizophrenia, bipolar disorder, and major depressive disorder. Despite its unique pharmacological profile, the impact of cyamemazine on clinical outcomes, treatment adherence, and quality of life (QoL) remains inadequately studied. This study addresses the significant gap in understanding the clinical impact of cyamemazine, a widely used yet under-researched antipsychotic.</p><p><strong>Methods: </strong>This observational study was conducted at a university psychiatry unit in Marseille, France, involving patients with SMDs. Sociodemographic, clinical, and comorbid characteristics were assessed, along with treatment adherence, QoL, and side effects using validated instruments including the Medication Adherence Rating Scale (MARS) and the Schizophrenia Quality of Life Scale (SQoL-18). Multivariate analyses were performed to explore the associations between cyamemazine use and clinical outcomes.</p><p><strong>Results: </strong>A total of 1,248 patients were included with 55 (4.4%) using cyamemazine. Cyamemazine users presented more severe clinical profiles, with higher anxiety, more hospitalizations, and poorer functioning. Although cyamemazine's anxiolytic effects may improve adherence, its sedative and metabolic side effects were associated with reduced QoL and functional impairment.</p><p><strong>Conclusions: </strong>The study highlights the need for personalized treatment strategies that weigh the benefits of cyamemazine against its potential risks. Integrating pharmacological and non-pharmacological interventions could enhance patient outcomes.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma by association revealed in a survey conducted among UNAFAM members.","authors":"Jean-Yves Giordana, Hervé Caci","doi":"10.1016/j.encep.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.encep.2024.12.007","url":null,"abstract":"<p><strong>Background: </strong>Stigma by association (also known as secondary, family, or courtesy stigma) adds to public stigma and self-stigma. First described by Erwin Goffman in 1963, it affects those close to stigmatized individuals, particularly people with mental health conditions. King et al.'s scale from 2007 models public stigma based on three components: Discriminatory Reactions, Disclosure Concerns, and Positive Aspects.</p><p><strong>Method: </strong>King's scale was adapted for use by family members and administered through UNAFAM's (National Union of Families and Friends of People with Mental Health Conditions) online survey. The sample included 3650 participants (2962 women). Confirmatory and exploratory factor analyses were conducted to examine the scale's structure. We explored the effects of sex and kinship on factor scores using ANOVA/ANCOVA models.</p><p><strong>Results: </strong>While confirmatory factor analyses showed significant deviation from the original structure, exploratory analyses largely recovered the three original dimensions. The \"Discrimination\" dimension revealed experienced and perceived prejudice along with resulting reactions. The \"Disclosure\" dimension demonstrated persistent difficulties in discussing a family member's mental health condition due to fears of personal and professional consequences. The \"Positive Aspects\" dimension showed that respondents became more understanding and tolerant toward their family member with a mental health condition, although only 40% reported becoming more resilient through this experience.</p><p><strong>Conclusions: </strong>The adapted King's scale can now be used to investigate determinants and consequences of stigma by association in other populations, including neurodevelopmental disorders (such as autism spectrum disorder and attention-deficit/hyperactivity disorder), schizophrenia, mood disorders, substance use disorders, and dementias.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective responses in adults with severe obesity living or not with a mental disorder during two consecutive 6-min walking exercises.","authors":"Louis Pitois, Aurélie Baillot, Benjamin Pageaux, Ahmed Jérôme Romain","doi":"10.1016/j.encep.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.encep.2024.12.005","url":null,"abstract":"<p><strong>Objectives: </strong>Affective response during physical activity can partly determine its adherence in adults with severe obesity living or not with a mental disorder. This study examined affective responses to physical activity in adults with severe obesity living or not with a mental disorder.</p><p><strong>Materials and methods: </strong>Two groups (24 adults with severe obesity, body mass index=44.4kg/m², SD=6.5; 20 adults with severe obesity and mental disorders, body mass index=44.1kg/m², SD=9.3) completed two 6-min walking exercises with affective responses assessed at each minute.</p><p><strong>Results: </strong>No between-group effect in the distance walked was found. Results showed a significant time effect indicating a decline in pleasure over time in both groups from the first to the second 6-min walking exercise No interaction effects were detected in both 6-min walking exercise.</p><p><strong>Discussion: </strong>Affective responses similarly declined in both groups indicating that obesity, rather than the presence of a mental disorder, is partly responsible for this decline.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of insomnia: Cultural and societal aspects from a European survey.","authors":"Sylvie Royant-Parola, Isabelle Poirot, Pierre A Geoffroy","doi":"10.1016/j.encep.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.encep.2025.01.004","url":null,"abstract":"<p><strong>Objectives: </strong>This European study explored the cultural and societal aspects of chronic insomnia by means of a survey undertaken in France, Germany, Italy, Spain, and the United Kingdom. The primary objectives were to understand the impact of insomnia on the daily lives of patients, both personally and professionally, and to evaluate the patients' perceptions and coping strategies thus identifying cultural differences in the management of this disorder.</p><p><strong>Methods: </strong>Based on online panels targeting insomnia sufferers, the survey included 755 patients aged 35 to 65 years with moderate to severe insomnia for at least three months, occurring at least three times per week (DSM-5 criteria for insomnia disorder, ISI score 15-28). Topics covered included the impact of insomnia on daily life, strategies for coping and managing insomnia, and patients' perceptions and views of insomnia.</p><p><strong>Results: </strong>A total of 755 patients completed the questionnaire. Most respondents were women (70%) and between 35 and 49 years of age (50%). About half of the patients (49%) had severe insomnia, with 49% experiencing it for over three years. Nearly 70% did not initially consider their insomnia serious, and 73% believed their condition would improve over time. Stress (39%), difficulty relaxing in the evening (37%), and a rapid flow of thoughts (37%) were identified as the main causes of insomnia. Insomnia was shown to significantly affect daily life, particularly work performance, relationships, and maintaining healthy habits. British patients were the most affected, with 85% reporting decreased work performance. In France, only 51% reported difficulties maintaining relationships. There were 77% of Britons who felt exposed to dangerous situations, such as drowsiness while driving (47%). Coping strategies varied by country but, overall, breathing exercises (43%), meditation (32%), and reducing caffeine intake (44%) were the most popular. Healthcare consultation approaches also varied. French patients consulted general practitioners (89%) but rarely specialists, while Germans consulted sleep specialists (20%) and psychiatrists (19%). Overall, 61% reported that doctors recommended lifestyle changes.</p><p><strong>Conclusions: </strong>The survey highlights cultural differences in insomnia perception and management in Europe. Insomnia is often trivialized, thus delaying management. The results underline the need to raise awareness among patients and healthcare professionals of the importance of insomnia and its consequences on mental and physical health. Addressing chronic insomnia requires a multifaceted approach that includes cultural sensitivity, patient education, and proactive healthcare engagement. By understanding and integrating these elements, healthcare providers can better support patients to manage their condition, ultimately improving their quality of life.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide reattempts in adolescents and young adults after a first suicide attempt. Results from the SURAYA prospective cohort study.","authors":"Nadine Barakat, Jérôme Brunelin, Erika Abrial, Cécilia Neige, Benoît Chalancon, Jacqueline Scholl, Anthony Fourier, Julie Brossaud, Marianne Hermand, Vincent Besch, Louis Simon, Charline Magnin, Edouard Leaune, Emmanuel Poulet","doi":"10.1016/j.encep.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.encep.2024.12.004","url":null,"abstract":"<p><strong>Introduction: </strong>Suicide is a particularly major public health concern among young people as it is the fourth cause of death in youth aged 15-29. Despite various prevention strategies and efforts, the rate of suicide attempts among youth has increased over time and has risen even further since the COVID-19 pandemic.</p><p><strong>Objectives: </strong>The aim of this study was to ascertain the prevalence of suicide reattempts within 3months in a cohort of young first-time suicide attempters aged 16 to 25years. Exploratory objectives were to investigate potential risk factors associated with reattempts in this population.</p><p><strong>Methods: </strong>We conducted a prospective, naturalistic, single-center cohort study including 182 patients hospitalized in emergency psychiatry for a first suicide attempt. Data on 31 sociodemographic, clinical and biological factors known to be associated with suicide were collected at baseline.</p><p><strong>Results: </strong>Out of the 182 patients included, 146 participants remained for the 3-months follow-up analysis (mean age: 19.71±2.5years, 71.9% female). Twenty of them reattempted suicide: yielding a prevalence of 13.7% (14.3% of females and 12.2% of males). Only four clinical and biological factors under study were significantly associated with suicide reattempt.</p><p><strong>Conclusion: </strong>Our findings underscore the critical need for targeted prevention strategies for adolescents and young adults, as they represent a high-risk group for early suicide reattempts. Further research into the factors associated with recurrent suicide attempts is essential to more accurately characterize the profiles of young individuals who reattempt suicide, thereby informing the development of effective preventive interventions and avoiding negative outcomes.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[What useful qualities and practices should mental health care providers exhibit? A mixed-methods user-led study].","authors":"Kevin-Marc Valery, Sarah Guionnet, Pauline Boivert, Julien Bonilla-Guerreo, Meryl Caiada, Jean-Marc Destaillats, Simon Felix, Thomas Fournier, Emma Tison, Louis Violeau, Pascal-André Berrier, Antoinette Prouteau","doi":"10.1016/j.encep.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.encep.2024.12.006","url":null,"abstract":"<p><strong>Introduction: </strong>The Clubhouse Bordeaux initiative, a community of individuals with direct experience of mental health services, decided to identify and examine positive experiences in order to enhance the provision of care that aligns with the preferences of service users.</p><p><strong>Objective: </strong>The aim of this study was twofold: firstly, to identify the professional practices and skills that mental health service users consider to be useful, and secondly, to assess the relative importance of these practices and skills in terms of frequency of occurrence.</p><p><strong>Methodology: </strong>A survey was conducted online with the objective of gathering information from psychiatric service users in France. The content of the survey was developed through a participatory, user-led study approach.</p><p><strong>Results: </strong>A total of 128 users participated in the survey. Ten practices, such as user involvement in decision-making, accurate diagnosis, person-centered support, and clear information about care, were identified as useful. Similarly, ten professional skills, including trust, empathy, honesty, transmission of hope, and belief in the potential for recovery, were also considered beneficial. However, it was observed that few service users reported frequently benefiting from these practices and skills.</p><p><strong>Conclusions and implications: </strong>The results indicate that service users seek professionals who are both experts in providing support and trusted equals who facilitate their empowerment. Implementing these practices and skills in clinical practice could better align with the preferences expressed by service users.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness in rehabilitation of the paper Multiple Errands Test to assess executive functions in patients with schizophrenia, bipolar or autism disorders. Results from the REHABase cohort study.","authors":"Denis Boucaud-Maitre, Julien Plasse, Isabelle Chéreau-Boudet, Benjamin Gouache, Emilie Legros-Lafarge, Catherine Massoubre, Nathalie Guillard-Bouhet, Frédéric Haesebaert, Nicolas Franck, Guillaume Barbalat","doi":"10.1016/j.encep.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.encep.2025.01.001","url":null,"abstract":"<p><strong>Objective: </strong>Neuropsychological tests measuring executive functions are useful for identifying specific cognitive disorders, but they have limits for characterizing executive dysfunction in everyday activities. This study aims to investigate the socio-demographic, clinical, and psychosocial features associated with executive functions in patients with schizophrenia, bipolar, and autism spectrum disorders using a Paper Multiple Errands Test.</p><p><strong>Patients or materials and methods: </strong>A total of 1071 adults with schizophrenia spectrum disorder, 329 with bipolar spectrum disorder, and 254 with autism spectrum disorder were recruited from the French National Centers of Reference for Psychiatric Rehabilitation (REHABase) cohort between January 2016 and October 2022. Executive function severity was assessed by the multiple errands test. Socio-demographic and clinical data were extracted as well as results from standardized scales for self-stigma, quality of life, well-being, and self-esteem. Data were analyzed using bivariate and Quasi-Poisson regression model.</p><p><strong>Results: </strong>The mean number of errors measured by the paper multiple errands test was 3.1±1.9 in patients with schizophrenia spectrum disorder (n=1071), 2.4±1.8 in bipolar disorder (n=329), and 2.6±1.9 in autism disorder (n=254). Factors significantly associated with the number of errors were (1) age, illness duration, number of hospitalizations, education level, working memory, and insight in patients with schizophrenia; (2) age, illness duration, number of hospitalizations, education level, and working memory in patients with bipolar disorder; and (3) education level and working memory in patients with autism disorder. The number of errors was associated with lower quality of life, well-being and self-esteem, but not self-stigma, in all three disorders.</p><p><strong>Conclusion: </strong>The predictors of executive dysfunction observed with the paper multiple errands test were similar to those found with other tests of executive function. The paper multiple errands test is associated with essential psychosocial determinants in rehabilitation, particularly quality of life and well-being, and provides a wide range of information about functioning in community living.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of a sample of 90 detainees for jihadist terrorism.","authors":"Guillaume Monod, Marine Ambar-Akkaoui, Ludovic Levasseur, Alexandra Pham-Scottez","doi":"10.1016/j.encep.2024.06.006","DOIUrl":"https://doi.org/10.1016/j.encep.2024.06.006","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Although research into the process of jihadist radicalization has developed in less than 10 years, few studies on the subject have been carried out by psychiatrists, and the prevalence of psychiatric disorders among people incarcerated for terrorism in France is unknown. Our objectives were to estimate the prevalence of psychiatric disorders in a sample of people incarcerated for jihadist terrorism and to characterize and compare men and women (socio-demographics, psychiatric diagnoses, trauma, substances, conversion to Islam).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;Ninety adults in detention for jihadist terrorism were included; the data used were extracted from the patient file (gender, age, marital and parental status, level of education, employment, history of specialized follow-up) and from clinical interviews conducted by the same interviewer (history of depression, suicide attempt, psychiatric follow-up, psychotropic medication use, psychiatric hospitalization, current ICD-10 psychiatric diagnosis, substance abuse and withdrawal, trauma, lone or in group terrorism). Categorical variables were described with proportions, and qualitative variables with means, medians and standard deviations. Comparisons were made between men and women using the t-Student test (comparisons of means) or the Chi&lt;sup&gt;2&lt;/sup&gt; (comparisons of proportions). Analyses were performed using R Studio software.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;30% of incarcerated people had a current psychiatric diagnosis. The most frequent diagnosis was \"personality disorder\" (11%), followed by \"schizophrenia, schizotypal disorders and delusional disorders\" (8%) and \"neurotic and stress-related disorders and somatoform disorders\" (6%). Women had a higher lifetime history of depression and psychiatric follow-up than men, but men were more likely to have a current psychiatric diagnosis. The marital and parental status of men and women also differed: men were better socially integrated, with higher levels of education and access to employment. Women were more likely to have been taken into care by the child welfare system, to have family responsibilities, and to be divorced or widowed. Men were much more likely than women to engage in addictive behaviors and were also much more likely to wean themselves from their substance use. Women had a very high prevalence of trauma, sexual violence and/or domestic or marital violence which was not the case for men. The phenomenon of conversion to Islam concerned a large and identical proportion of men and women. Finally, for the first time in the literature on the subject our study explored the link between male lone actors and the prevalence of psychiatric pathology (90%) and found a very significant association between being a lone actor and having a psychiatric diagnosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study thus contributes to the development of new criteria for the detection, assessment and management of people r","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a French Fear of Missing Out Scale.","authors":"Elie Andraos, Pierluigi Graziani, Jonathan Del Monte","doi":"10.1016/j.encep.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.encep.2024.12.003","url":null,"abstract":"<p><p>This study aimed to translate and assess the psychometric properties of a French Fear of Missing Out scale (PPC). The Fear of missing out is defined as a \"pervasive apprehension that others might be having rewarding experiences from which one is absent; it is characterized by the desire to remain continually connected to what others are doing\". One hundred and thirty-eight participants completed the PPC, a French version of the Internet Addiction Test - Social Media (IAT-RS), a French Smartphone Addiction Scale - Short Version (SAS-SV) and some subscales of the French Revised Symptom Checklist (SCL-90-R) to test the validity of the scale. A principal components analysis revealed an 8-item PPC with a single factor and good internal validity. Correlations with the SAS-SV and the IAT-RS revealed moderate positive correlations confirming the convergent validity of the scale and supporting the use of the scale for further research findings related to the SCL-90-R subscales. Additional analyses allowed us to note that PPC fully mediated the relationship between anxiety and smartphone addiction, as well as between depression and smartphone addiction. It was also revealed that PPC partially mediated the relationship between anxiety and social media addiction and depression and social media addiction. The PPC has good psychometric qualities and opens up the possibility of assessing the fear of missing out in French populations and testing its relationships with various psychological disorders such as addictive behaviors.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacy activities specific to patients treated with lithium.","authors":"Candice Niot, Elodie Cuvelier, Arnaud Leroy, Guillaume Vaiva, Michel Maron, Oliver Cottencin, Pascal Odou, Ali Amad, Bertrand Décaudin","doi":"10.1016/j.encep.2024.11.019","DOIUrl":"https://doi.org/10.1016/j.encep.2024.11.019","url":null,"abstract":"<p><strong>Objectives: </strong>Medication compliance in lithium-treated patients is poor (43-46%) and may be responsible for relapse or toxicity. Improving understanding of treatment principles leads to increased medication adherence. To do this, targeted and personalised pharmaceutical interviews on lithium were developed and implemented by a clinical pharmacy team in adult psychiatric departments of the Lille university hospital center. The primary aim of this work was to assess medication adherence with lithium, patients' understanding of the drug and of potential adverse effects. A secondary objective was to evaluate the feasibility of these pharmaceutical interviews in practice.</p><p><strong>Methods: </strong>Implementation of self-assessment questionnaires measuring medication adherence (Medication Adherence Rating Scale) as well as knowledge of lithium and risk of exposure to toxic effects (Lithium Knowledge Test) of patients. Conducting targeted pharmaceutical interviews about lithium, and recording of time spent, satisfaction of medical teams and difficulties encountered.</p><p><strong>Results: </strong>Twenty patients were included in the 6-month study. Every patient benefited from a personalized pharmaceutical interview by a pharmacy intern focused on lithium during his hospitalization. Lithium adherence, patient knowledge and risk exposure to lithium toxicity was 5.5±0.9 (target ≥8), 8.9±0.9 (target >6) and 4.0±0.5 (target <4). The median time required for these new activities was 95minutes per patient. Medical satisfaction was observed in 70% to 100% of cases depending on the criterion assessed. The lack of pharmaceutical time and communication difficulties were the main obstacles encountered.</p><p><strong>Conclusion: </strong>Medication compliance in patients treated with lithium is poor as described in the literature. To improve this and to optimise drug management, patients have benefited from targeted and personalised pharmaceutical interviews. The satisfaction of patients and the medical team made it possible to sustain these new pharmaceutical activities.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}