{"title":"摩洛哥精神分裂症患者的抗核抗体分析：一项单中心研究","authors":"Yassmine Kassal, Aboubaker El Hessni, Abdelhalim Mesfioui, Khadija Fritah, Naila Nakidi, Wahid Boukouaci, Amine Rkhaila, Jihane Bouassida, Siham Belbachir, Fouad Laboudi, Abderrazak Ouanass, Marion Leboyer, Ryad Tamouza, Naima Arji","doi":"10.1016/j.encep.2025.05.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The present study investigates the prevalence of antinuclear autoantibodies among Moroccan patients with schizophrenia compared to healthy controls and examines the potential associations between the presence of antinuclear autoantibodies and selected sociodemographic and clinical characteristics of patients with schizophrenia.</p><p><strong>Methods: </strong>A cross-sectional assessment was conducted between May 2020 and December 2022. The study involved a total of 157 patients who were diagnosed with schizophrenia and admitted to the Ar-Razi Psychiatric Hospital of Ibn Sina University Hospital Center of Rabat, Morocco. A total of 115 healthy controls (blood donors) were recruited from the transfusion center of Kenitra, Morocco. Antinuclear autoantibodies screening was performed by an indirect immunofluorescence assay (IFA) using HEp-2 cells/liver (Monkey), and 16 specificities of nuclear antigens (ENA) were tested using immunodot assay on an automated platform.</p><p><strong>Results: </strong>The prevalence of antinuclear autoantibodies was significantly higher in patients as compared to healthy control (35 vs. 12.7% with P<0.05) suggesting strongly underlying autoimmune processes in the studied patients. Among the 55 samples tested positive for antinuclear autoantibodies in patients, a total of 29 samples had a positive immunodot result against the following antigens: Jo1, SSA, SSB, Ro 52, AMA-M2, PM-Scl, Sm and Sm/RNP. Logistic regression analysis identified tobacco consumption as the only significant predictor of positive antinuclear autoantibodies (B=2.179, P=0.018).</p><p><strong>Conclusion: </strong>This preliminary study provides original data on the prevalence of antinuclear autoantibodies in Moroccan patients with schizophrenia and reveals a strong association between tobacco consumption and antinuclear autoantibodies positivity. The present findings replicate the previously reported association between autoimmune processes and schizophrenia in other geographical areas and warrant extension to other circulating autoantibodies towards a full profiling of autoimmunity in Moroccan patients with schizophrenia.</p>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antinuclear antibodies profiling in Moroccan patients with schizophrenia: A single center study.\",\"authors\":\"Yassmine Kassal, Aboubaker El Hessni, Abdelhalim Mesfioui, Khadija Fritah, Naila Nakidi, Wahid Boukouaci, Amine Rkhaila, Jihane Bouassida, Siham Belbachir, Fouad Laboudi, Abderrazak Ouanass, Marion Leboyer, Ryad Tamouza, Naima Arji\",\"doi\":\"10.1016/j.encep.2025.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The present study investigates the prevalence of antinuclear autoantibodies among Moroccan patients with schizophrenia compared to healthy controls and examines the potential associations between the presence of antinuclear autoantibodies and selected sociodemographic and clinical characteristics of patients with schizophrenia.</p><p><strong>Methods: </strong>A cross-sectional assessment was conducted between May 2020 and December 2022. The study involved a total of 157 patients who were diagnosed with schizophrenia and admitted to the Ar-Razi Psychiatric Hospital of Ibn Sina University Hospital Center of Rabat, Morocco. A total of 115 healthy controls (blood donors) were recruited from the transfusion center of Kenitra, Morocco. Antinuclear autoantibodies screening was performed by an indirect immunofluorescence assay (IFA) using HEp-2 cells/liver (Monkey), and 16 specificities of nuclear antigens (ENA) were tested using immunodot assay on an automated platform.</p><p><strong>Results: </strong>The prevalence of antinuclear autoantibodies was significantly higher in patients as compared to healthy control (35 vs. 12.7% with P<0.05) suggesting strongly underlying autoimmune processes in the studied patients. Among the 55 samples tested positive for antinuclear autoantibodies in patients, a total of 29 samples had a positive immunodot result against the following antigens: Jo1, SSA, SSB, Ro 52, AMA-M2, PM-Scl, Sm and Sm/RNP. Logistic regression analysis identified tobacco consumption as the only significant predictor of positive antinuclear autoantibodies (B=2.179, P=0.018).</p><p><strong>Conclusion: </strong>This preliminary study provides original data on the prevalence of antinuclear autoantibodies in Moroccan patients with schizophrenia and reveals a strong association between tobacco consumption and antinuclear autoantibodies positivity. The present findings replicate the previously reported association between autoimmune processes and schizophrenia in other geographical areas and warrant extension to other circulating autoantibodies towards a full profiling of autoimmunity in Moroccan patients with schizophrenia.</p>\",\"PeriodicalId\":51042,\"journal\":{\"name\":\"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.encep.2025.05.001\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.encep.2025.05.001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究调查了摩洛哥精神分裂症患者中抗核自身抗体的患病率，并与健康对照进行了比较，并研究了抗核自身抗体的存在与精神分裂症患者的社会人口学和临床特征之间的潜在关联。方法：于2020年5月至2022年12月进行横断面评估。这项研究共涉及157名被诊断为精神分裂症的患者，他们住在摩洛哥拉巴特伊本西纳大学医院中心的Ar-Razi精神病院。从摩洛哥Kenitra输血中心共招募了115名健康对照者（献血者）。使用HEp-2细胞/肝脏（猴子）进行间接免疫荧光法（IFA）筛选抗核自身抗体，在自动化平台上使用免疫点法检测16种核抗原（ENA）的特异性。结果：摩洛哥精神分裂症患者中抗核自身抗体的患病率明显高于健康对照组（35% vs. p12.7%）。结论：本初步研究提供了摩洛哥精神分裂症患者中抗核自身抗体患病率的原始数据，并揭示了烟草消费与抗核自身抗体阳性之间的密切联系。目前的研究结果重复了先前在其他地理区域报道的自身免疫过程与精神分裂症之间的关联，并保证将其扩展到其他循环自身抗体，以全面分析摩洛哥精神分裂症患者的自身免疫。
Antinuclear antibodies profiling in Moroccan patients with schizophrenia: A single center study.
Objectives: The present study investigates the prevalence of antinuclear autoantibodies among Moroccan patients with schizophrenia compared to healthy controls and examines the potential associations between the presence of antinuclear autoantibodies and selected sociodemographic and clinical characteristics of patients with schizophrenia.
Methods: A cross-sectional assessment was conducted between May 2020 and December 2022. The study involved a total of 157 patients who were diagnosed with schizophrenia and admitted to the Ar-Razi Psychiatric Hospital of Ibn Sina University Hospital Center of Rabat, Morocco. A total of 115 healthy controls (blood donors) were recruited from the transfusion center of Kenitra, Morocco. Antinuclear autoantibodies screening was performed by an indirect immunofluorescence assay (IFA) using HEp-2 cells/liver (Monkey), and 16 specificities of nuclear antigens (ENA) were tested using immunodot assay on an automated platform.
Results: The prevalence of antinuclear autoantibodies was significantly higher in patients as compared to healthy control (35 vs. 12.7% with P<0.05) suggesting strongly underlying autoimmune processes in the studied patients. Among the 55 samples tested positive for antinuclear autoantibodies in patients, a total of 29 samples had a positive immunodot result against the following antigens: Jo1, SSA, SSB, Ro 52, AMA-M2, PM-Scl, Sm and Sm/RNP. Logistic regression analysis identified tobacco consumption as the only significant predictor of positive antinuclear autoantibodies (B=2.179, P=0.018).
Conclusion: This preliminary study provides original data on the prevalence of antinuclear autoantibodies in Moroccan patients with schizophrenia and reveals a strong association between tobacco consumption and antinuclear autoantibodies positivity. The present findings replicate the previously reported association between autoimmune processes and schizophrenia in other geographical areas and warrant extension to other circulating autoantibodies towards a full profiling of autoimmunity in Moroccan patients with schizophrenia.
期刊介绍：
Une revue française de renommée internationale.
- Un comite de rédaction représentant tous les aspects de la prise en charge psychiatrique du patient.
- Une sélection rigoureuse d''articles faisant l''objet de plusieurs expertises.
- Des travaux d''auteurs et de chercheurs de renommée internationale.
- Des indexations dans les grandes bases de données (Current Contents, Excerpta Medica, etc.).
- Un facteur d''impact qui témoigne de la grande notoriété de la revue.
La tribune des publications originales de haut niveau.
- Une très grande diversité des sujets traités, rigoureusement sélectionnés à travers des sommaires dynamiques :
- des éditoriaux de médecins référents,
- une revue de presse sur les actualités internationales,
- des articles originaux pour approfondir vos connaissances,
- des mises au point et des cas cliniques pour engager votre réflexion sur les indications et choix possibles au travers de mises en situation clinique,
- des dossiers thématiques pour faire le tour d''une question.
- L''actualité de l''AFPB : L''Encéphale publie régulièrement des comptes rendus de l''Association française de psychiatrie clinique.
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