Current Problems in Cardiology最新文献

{"title":"Noninvasive assessment of myocardial stiffness using shear wave elastography in Amyloidosis and Fabry disease","authors":"Caio RF Cafezeiro PhD ,&nbsp;Aristóteles AC Neto PhD ,&nbsp;Cristhian E Romero MD ,&nbsp;Natália M Pereira MD ,&nbsp;Bruno VK Bueno MD ,&nbsp;João H Rissato MD ,&nbsp;Fernando L Pereira MD ,&nbsp;Maria C Chamas PhD ,&nbsp;Marcelo D Tavares PhD ,&nbsp;Felix JA Ramires PhD ,&nbsp;Wilson Mathias Jr PhD ,&nbsp;Carlos E Rochitte PhD ,&nbsp;Viviane T Hotta PhD ,&nbsp;Fábio Fernandes PhD","doi":"10.1016/j.cpcardiol.2025.103038","DOIUrl":"10.1016/j.cpcardiol.2025.103038","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>Diastolic function comprises MS and impaired relaxation, and is essential for the comprehensive analysis of heart failure. The goal of this study was to investigate the use of cardiac shear wave elastography for assessing shear wave propagation speed and myocardial stiffness (MS) in Fabry disease (FD), cardiac amyloidosis (CA) and healthy volunteers (HV).</div></div><div><h3>Methods</h3><div>We prospectively enrolled 60 participants, with 20 patients each in the CA, FD and HV groups. Echocardiogram, blood exams and walking test were achieved. MS evaluation was performed using an ultrasound scanner. <strong>Results</strong>: Shear wave propagation speed and MS were significantly higher in patients with CA than in HV in the basal anteroseptal segment (MS PLAX 6.6 ± 1.4 kPa vs. 5.38 ± 1.1 kPa, respectively, <em>p</em> = 0.01; PSAX 6.86 ± 1.4 kPa vs. 5.6 ± 1.2 kPa, respectively, <em>p</em> = 0.01) and in the right ventricle (5.9 ± 2.6 kPa vs. 4.0 ± 0.7 kPa, respectively, <em>p</em> = 0.003), with no difference in the mid anteroseptal segment and the apical septal. There was a difference in the MS of patients with CA in the right ventricle when compared to the FD group (5.9 ± 2.6 kPa vs. 4.4 ± 1.0 kPa, respectively, <em>p</em> = 0.01). There was no statistical difference between any myocardial segment in the FD group compared to the HV group. <strong>Conclusions</strong>: Shear wave propagation speed and MS were higher in patients with CA compared to FD and healthy volunteers. Evaluation of FD group did not reveal any difference from the control group</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 6","pages":"Article 103038"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takotsubo syndrome complicated by ventricular arrhythmias vs. Ventricular arrhythmias triggering Takotsubo syndrome","authors":"John E. Madias MD, FACC, FAHA","doi":"10.1016/j.cpcardiol.2025.103041","DOIUrl":"10.1016/j.cpcardiol.2025.103041","url":null,"abstract":"<div><div>The present review focuses on the thesis that there is an amphidromic relationship between ventricular arrhythmias (VA) and takotsubo syndrome (TTS), with VA emerging as complications of TTS, and TTS being precipitated by VA with or without culmination in cardiac arrest (CA). The mechanism(s) of these phenomena is(are) being explored, and the emerging diagnostic possibilities are outlined. Emphasis is made on the need to upgrade our current approach in diagnosis TTS, and its occasional presence as a “TTS component”, in association with other cardiovascular and other comorbidities. The diagnosis and management of various emerging TTS subtypes, with preceding or following VA/CA is outlined, the various established or possible phenotypes are presented, and ways to confirm their pathophysiologic trajectories are offered.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 6","pages":"Article 103041"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidimensional Approach to Understanding Genetic Diversity, Risk Stratification, and Personalized Interventions in Pediatric Hypertrophic Cardiomyopathy","authors":"Mona Alromaihi ,&nbsp;Faris Alrumaihi ,&nbsp;Wanian M. Alwanian ,&nbsp;Hajed Obaid Alharbi ,&nbsp;Nouf Nasser AlDuayji ,&nbsp;Somayah Mohammad Alfifi ,&nbsp;Amin A. Al-Doaiss ,&nbsp;Fahad M Alshabrmi ,&nbsp;William Thornbury ,&nbsp;Shahid Ullah Khan","doi":"10.1016/j.cpcardiol.2025.103040","DOIUrl":"10.1016/j.cpcardiol.2025.103040","url":null,"abstract":"<div><div>Hypertrophic cardiomyopathy (HCM) in children presents unique challenges distinct from adult manifestations, with potentially devastating consequences, including sudden cardiac death. This comprehensive review synthesizes current evidence on the pathophysiology, clinical presentation, and management of pediatric HCM, highlighting critical differences from adult populations. While affecting approximately 1 in 500 individuals, pediatric HCM demonstrates more significant etiological heterogeneity, with up to 35% of cases stemming from non-sarcomeric causes, including RASopathies, metabolic disorders, and syndromic conditions. This etiological diversity contributes to variable disease trajectories and treatment responses, creating a significant research gap in pediatric-specific management protocols. Current pharmacological approaches primarily employ beta-blockers as first-line therapy, with calcium channel blockers serving as alternatives for intolerant patients. However, these conventional medications manage symptoms without addressing underlying pathophysiology or preventing disease progression. Emerging investigational therapies, including angiotensin receptor blockers and myosin inhibitors like mavacamten, show promise in preliminary studies but lack robust pediatric-specific evidence. Surgical interventions, including septal myectomy and the modified Konno procedure, demonstrate efficacy in medication-refractory cases but carry higher complication risks in younger patients. The critical research gap lies in developing targeted therapeutic approaches for pediatric-specific HCM subtypes, particularly those associated with syndromic and metabolic disorders. Additionally, risk stratification models for sudden cardiac death prevention remain inadequately validated in pediatric populations. This review identifies the urgent need for pediatric-focused clinical trials investigating both conventional and novel therapies alongside the development of age-appropriate risk assessment tools to guide personalized management strategies for this vulnerable population.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 6","pages":"Article 103040"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-analysis of Right Ventricular Changes in Cancer-therapy - The Forgotten Ventricle in Cardio-Oncology.","authors":"Caroline O Fischer-Bacca, Ramon Huntermann, Juan Peres de Oliveira, Francisco B Alexandrino, Mariane Y Sato, Rhanderson Cardoso, Rodrigo F Gomes, Edielle S Melo","doi":"10.1016/j.cpcardiol.2025.103039","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2025.103039","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer therapy-induced cardiotoxicity (CTRCD) is a significant adverse effect of oncologic treatment, associated with considerable morbidity and mortality. Among CTRCD, heart failure stands out in prevalence and severity, with left ventricular dysfunction being the focus of most studies. Right ventricle (RV) may also be damaged by CTRCD, however the effects of CTRCD on RV function (RVF) have not been elucidated.</p><p><strong>Objective: </strong>We aimed to conduct a systematic review and meta-analysis evaluating RV echocardiographic parameters in patients undergoing chemotherapy.</p><p><strong>Methods: </strong>PubMed, Embase and Cochrane were searched for studies that evaluated RV parameters during cancer therapy. Statistical analysis was performed using the R statistical software. We computed pooled mean differences (MD), adopting a random-effects model, with a significance level of 0.05. A correlation coefficient of 0.5 was assumed for paired measurements. Heterogeneity was assessed using the I² statistic.</p><p><strong>Results: </strong>We included 1,520 patients from 25 studies, 73% of whom were women and with a mean age of 51.1±16.5 years. RVF was significantly lower after CTRCD, with reduction in fractional area change (MD=-2.29% [95% CI: -3.63,-0.95]), RV global longitudinal strain (MD=2.49% [95% CI: 1.73, 3.25]), and RV free wall strain (MD=3.21% [95% CI: 2.32, 4.11]). Additionally, tricuspid annular plane systolic excursion was significantly reduced (MD=-1.44mm [95% CI: -1.94, -0.95]) and pulmonary artery systolic pressure was significantly higher (MD=1.60mmHg [95% CI: 0.64, 2.56]) after chemotherapy.</p><p><strong>Conclusion: </strong>The assessment of RVF is important in CTRCD, and its quantification should be included in clinical follow-up during cancer treatment. Further research is needed to elucidate the underlying factors contributing to RV dysfunction and to develop methods for its early detection.</p>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"103039"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga in Obesity Management: Reducing cardiovascular risk and enhancing well-being- A review of the current literature","authors":"Ganagarajan Inbaraj ,&nbsp;Sarita Bajaj ,&nbsp;Puneet Misra ,&nbsp;Nandini kandimalla ,&nbsp;Abhishek Thapa ,&nbsp;Anit Ghosal ,&nbsp;Urveesh Sharma ,&nbsp;Pascal charles ,&nbsp;Harish Pobbati ,&nbsp;Intkhab Hashmi ,&nbsp;Bhavit Bansal ,&nbsp;Jacques de Vos ,&nbsp;Debasmita De ,&nbsp;Omar Elshafei ,&nbsp;Aditi Garg ,&nbsp;Indranill Basu-Ray","doi":"10.1016/j.cpcardiol.2025.103036","DOIUrl":"10.1016/j.cpcardiol.2025.103036","url":null,"abstract":"<div><h3>Background</h3><div>Obesity, a global epidemic, significantly increases cardiovascular disease (CVD) risk. Conventional treatments often lack long-term efficacy, emphasizing the need for integrative, sustainable approaches.</div></div><div><h3>Objective</h3><div>This review assesses the role of yoga as a complementary intervention in obesity management and its effectiveness in reducing cardiovascular risk.</div></div><div><h3>Methods</h3><div>We systematically reviewed literature up to March 2024 from Medline/PubMed, Scopus, Embase and the Cochrane Central Library. The focus was on randomized controlled trials (RCTs), observational studies, systematic reviews and meta-analyses evaluating the impact of yoga on obesity-related outcomes and cardiovascular risk factors. Studies were reviewed for quality, outcomes, and both physiological and psychological effects of yoga on obese individuals.</div></div><div><h3>Results</h3><div>Yoga interventions consistently yielded positive results in reducing body mass index (BMI), waist circumference, and body fat. These physical changes correlate with significant improvements in cardiovascular markers, including blood-pressure, cholesterol levels, endothelial and autonomic functions. Yoga also enhances stress management and psychological well-being, addressing both mental and physical facets of obesity. The benefits extend beyond mere weight reduction, affecting systemic inflammation and metabolic health, crucial for mitigating CVD risks.</div></div><div><h3>Conclusion</h3><div>Yoga represents a promising, non-pharmacological approach to obesity management and CVD risk reduction. Its holistic impact on physical and psychological health makes it a viable adjunct therapy in comprehensive obesity management, fostering sustainable lifestyle changes and long-term health benefits.</div></div><div><h3>Implications</h3><div>Incorporating yoga into standard obesity management protocols could enhance therapeutic outcomes. Future research should standardize yoga interventions to better integrate them into modern healthcare and explore their long-term cardiovascular effects.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 6","pages":"Article 103036"},"PeriodicalIF":3.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting trends and disparities in colorectal cancer and heart failure-related mortality in the United States: A two-decade retrospective analysis","authors":"Ahmed Kamal Siddiqi MBBS Siddiqi AK ,&nbsp;Maryam Shahzad MBBS ,&nbsp;Muhammad Talha Maniya MBBS ,&nbsp;Muhammad Azhar Chachar MBBS ,&nbsp;Naaemah Saleem MBBS ,&nbsp;Mariana Garcia MD ,&nbsp;Raymundo A. Quintana MD ,&nbsp;Sagar Amin MD ,&nbsp;Mohammed Ferras Dabbagh MD ,&nbsp;Carlo N. De Cecco MD, PhD ,&nbsp;Muhammad Naeem MD","doi":"10.1016/j.cpcardiol.2025.103034","DOIUrl":"10.1016/j.cpcardiol.2025.103034","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) and heart failure (HF) are significant contributors to morbidity and mortality, particularly when they co-occur. This study aims to analyze the trends in mortality related to both CRC and HF from 1999 to 2020, identifying demographic and geographical variations that could inform targeted interventions.</div></div><div><h3>Methods</h3><div>We examined death certificate data from the CDC WONDER database to assess trends in CRC and HF-related mortality over a 22-year period. We calculated annual percentage changes (APCs) in age-adjusted mortality rates (AAMRs), stratified by race, gender geographical region and age group.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, there were 60,918 deaths attributed to CRC and HF. The AAMRs declined from 9.6 per 100,000 in 1999 to 0.92 in 2015, followed by an increase to 1.12 in 2020. Men consistently exhibited higher AAMRs (1.6) compared to women (1.07). By race, non-Hispanic Black individuals had the highest AAMRs (1.36), closely followed by non-Hispanic Whites (1.35), with Hispanic (0.69) and non-Hispanic Asian or Pacific Islander individuals (0.54) having lower rates. Geographical analysis revealed that the Midwest had the highest AAMR (1.53), with the Northeast (1.27), West (1.24), and South (1.16) following. Metropolitan areas recorded higher AAMRs (1.69) compared to non-metropolitan areas (1.19).</div></div><div><h3>Conclusion</h3><div>The study indicates a worrying rise in CRC and HF-related mortality from 2015 to 2020, following earlier declines. This upward trend across diverse demographics and regions highlights an urgent need for targeted public health strategies and healthcare policies to address these increases.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 6","pages":"Article 103034"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An artificial intelligence-informed proof of concept model for an ecological framework of healthy longevity forcing factors in the United States","authors":"Ross Arena PhD, PT ,&nbsp;Shuaijie Wang PhD ,&nbsp;Nicolaas P. Pronk PhD ,&nbsp;Colin Woodard MA, FRGS ,&nbsp;Tanvi Bhatt PhD, PT","doi":"10.1016/j.cpcardiol.2025.103035","DOIUrl":"10.1016/j.cpcardiol.2025.103035","url":null,"abstract":"<div><div>Unhealthy lifestyle behaviors are a doorway to downstream health consequences characterized by the following: 1) poor quality of life and diminished mobility; 2) increased likelihood of chronic disease risk factors and diagnoses; and, ultimately, 3) a shorter lifespan and healthspan. The aim of the current study is to assess if an ecological framework can predict U.S. lifespan via the use of artificial intelligence. The current study utilized several U.S. county-level datasets representing the predictive variables of the ecologic framework. A non-linear artificial intelligence statistical approach was used to assess the ability of these variables to predict life expectancy, death rate, and years of life lost. The R² values demonstrated that the performance of Extra trees models was different across the three outcomes, however, death rate always exhibited the highest R² for each feature number, indicating superior model accuracy for this outcome. Generally, an increase in the number of features led to improved model performance. Variables from all factors included in the proposed ecological framework were retained in the final predictive models. There is a need to understand why individuals/families/community, connected by shared cultural beliefs, decide to make one lifestyle behavior decision over another.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 5","pages":"Article 103035"},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor’s Message","authors":"","doi":"10.1016/j.cpcardiol.2025.103032","DOIUrl":"10.1016/j.cpcardiol.2025.103032","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 4","pages":"Article 103032"},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Authors","authors":"","doi":"10.1016/j.cpcardiol.2025.103033","DOIUrl":"10.1016/j.cpcardiol.2025.103033","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 4","pages":"Article 103033"},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0146-2806(25)00049-0","DOIUrl":"10.1016/S0146-2806(25)00049-0","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 4","pages":"Article 103027"},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}