Current Problems in Cardiology最新文献

Advancements, challenges, and innovative strategies in cardiac rehabilitation for patients with acute myocardial infarction: A systematic review. 急性心肌梗死患者心脏康复的进展、挑战和创新策略：系统综述。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102934

Sisheng Zhang, Yuhui Lin

{"title":"Advancements, challenges, and innovative strategies in cardiac rehabilitation for patients with acute myocardial infarction: A systematic review.","authors":"Sisheng Zhang, Yuhui Lin","doi":"10.1016/j.cpcardiol.2024.102934","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102934","url":null,"abstract":"Objects: To synthesize current evidence on the impact of cardiac rehabilitation (CR) on acute myocardial infarction (AMI) patients, explore the barriers to effective CR delivery, and evaluate the potential of innovative strategies to enhance the reach and effectiveness of CR programs.Methods: This systematic review analyzed literature from 2020-2024, focusing on advancements and challenges in CR for AMI patients. A comprehensive search strategy was applied using key terms \"cardiac rehabilitation\" and \"myocardial infarction,\" encompassing a variety of study designs.Results: CR significantly improves cardiovascular outcomes in AMI patients, yet faces challenges including low participation rates and adherence issues. Innovative strategies, such as home-based rehabilitation and digital health interventions, have shown potential in enhancing patient engagement and outcomes.Conclusion: CR is vital for AMI recovery but requires strategies to improve participation and adherence. Future research should focus on optimizing CR strategies to better serve the heart disease patient population. Technological advancements offer promising avenues for more personalized and accessible CR programs.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102934"},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Linking Psoriasis to Atrial Fibrillation: Insights from "Association between psoriasis and atrial fibrillation: A Systematic review and meta-analysis": Psoriasis and AF. 牛皮癣与心房颤动之间的关系：从 "牛皮癣与心房颤动之间的关系：从 "牛皮癣与心房颤动之间的关系 "中获得的启示"：牛皮癣与心房颤动之间的关系 "的启示：系统回顾和荟萃分析"：牛皮癣与心房颤动。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102933

Hong Zeng, Qi Shu, Jing Fang, Hailin Du, Ying Xue

{"title":"\"Linking Psoriasis to Atrial Fibrillation: Insights from \"Association between psoriasis and atrial fibrillation: A Systematic review and meta-analysis\": Psoriasis and AF.","authors":"Hong Zeng, Qi Shu, Jing Fang, Hailin Du, Ying Xue","doi":"10.1016/j.cpcardiol.2024.102933","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102933","url":null,"abstract":"Patients with psoriasis indeed face an elevated risk of developing atrial fibrillation (AF), underscoring the need for vigilant monitoring to facilitate early detection and intervention. Given the current body of evidence linking psoriasis and AF is derived from observational studies, there is a clear need for more robust, multicenter, large-scale randomized studies. Such research would help to validate and reinforce the findings from observational data. Large-scale, randomized studies are necessary to confirm the association between psoriasis and AF, addressing potential biases and confounding factors present in observational research. Future studies should consider a broader range of factors that may influence the incidence of AF in psoriasis patients. This includes assessing the impact of AF \"burden,\" which could refer to the frequency, duration, or overall impact of AF episodes on patients' health. Research should delve into the role of genetic predispositions that may contribute to the development of AF in patients with psoriasis. The influence of smoking and lipid levels, among other lifestyle and environmental factors, should be examined for their potential effects on the incidence of AF in psoriasis patients. An interdisciplinary team, including dermatologists, cardiologists, and other healthcare professionals, should collaborate to provide comprehensive care for patients with psoriasis.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102933"},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcatheter or Surgical Aortic Valve Replacement in high-risk patients. Insights from a third-world country. 高危患者接受经导管或外科主动脉瓣置换术。来自第三世界国家的启示。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102936

Muddassir Syed Saleem, Nidal Bin Kamran, Hafsa Kaleem

引用次数: 0

The Enigmatic Role of SIRT2 in the Cardiovascular System: Deciphering its Protective and Detrimental Actions to Unlock New Avenues for Therapeutic Intervention. SIRT2 在心血管系统中的神秘作用：解密其保护性和破坏性作用，开辟治疗干预的新途径。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102929

Abdulaziz Hassan Alhasaniah, Mohammed Alissa, Fahmy Gad Elsaid, Mahdi H Alsugoor, Mohammed S AlQahtani, Anwer Alessa, Khalid Jambi, Ghadah Shukri Albakri, Elizabeth Bennett

{"title":"The Enigmatic Role of SIRT2 in the Cardiovascular System: Deciphering its Protective and Detrimental Actions to Unlock New Avenues for Therapeutic Intervention.","authors":"Abdulaziz Hassan Alhasaniah, Mohammed Alissa, Fahmy Gad Elsaid, Mahdi H Alsugoor, Mohammed S AlQahtani, Anwer Alessa, Khalid Jambi, Ghadah Shukri Albakri, Elizabeth Bennett","doi":"10.1016/j.cpcardiol.2024.102929","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102929","url":null,"abstract":"Cardiovascular diseases (CVDs) are leading causes of mortality throughout the world, and hence, there is a critical need to elucidate their molecular mechanisms. The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated. However, the precise function of SIRT2 is only partially explored. Here, we review the current understanding of the involvement of SIRT2 in various cardiovascular pathologies, such as cardiac hypertrophy, ischemia-reperfusion injury, diabetic cardiomyopathy, and vascular dysfunction, with emphasis placed on the context-dependent protective or deleterious actions of SIRT2, including its wide array of catalytic activities which span beyond deacetylation. Furthermore, the review uncovers several unresolved research gaps for SIRT2 mechanisms by which SIRT2 modulates cardiac and vascular function during development and aging, thereby paving the way for the discovery of novel therapeutic targets as well as SIRT2-targeted interventions in the prevention and treatment of various cardiovascular diseases.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102929"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term prognosis of elderly patients undergoing atrial septal defect closure: are we acting too late? 接受房间隔缺损封堵术的老年患者的长期预后：我们的行动是否太晚了？

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102930

Maria Rita Lima, Mariana Sousa Paiva, Sérgio Maltês, Sérgio Madeira, Inês Mendes, José Pedro Neves, Rui Anjos

{"title":"Long-term prognosis of elderly patients undergoing atrial septal defect closure: are we acting too late?","authors":"Maria Rita Lima, Mariana Sousa Paiva, Sérgio Maltês, Sérgio Madeira, Inês Mendes, José Pedro Neves, Rui Anjos","doi":"10.1016/j.cpcardiol.2024.102930","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102930","url":null,"abstract":"Background: Atrial septal defects (ASD) often go unrecognized until very late in life. The impact of ASD closure on life expectancy in elderly patients remains unclear. This study compares the survival of patients≥65-years who underwent ASD closure with their average life expectancy (ALE).Methods: Single-centre retrospective study including all patients ≥65-years who underwent ostium secundum (OS) ASD closure (surgical/percutaneous) between 1998-2020. Baseline characteristics and the predicted peri-procedural ALE (as determined per pre-defined national ALE tables) for every given patient were assessed.Results: 706 patients underwent OS ASD closure, 37 (5%) had ≥65 years-mean age 69±5 years, 62% presented with heart failure. Mean ASD size=21±9mm, 22% patients had severe tricuspid regurgitation, mean systolic pulmonary artery pressure (SPAP)=50±11mmHg. Five patients were treated surgically. At a mean follow-up of 9±5 years, mortality rate was 46%, occurring 8.8±5.3 years after the procedure. 25 (68%) outlived their predicted ALE. Overall, the mean age of death did not differ from the predicted ALE (79±6 vs. 84±1 years, p=0.304), however there was a 10-year absolute difference between patients who died prematurely vs. those who surpassed ALE (77±4 vs. 87±3 years, p<0.001). Patients who failed to reach ALE had higher SPAP (58±10 vs. 46±8mmHg, p=0.001) and a higher incidence of severe tricuspid regurgitation (42 vs. 12%, p=0.040).Conclusion: Survival after late ASD closure was comparable to the expected ALE, though one-third of the patients died prematurely. Higher SPAP and severe tricuspid regurgitation were associated with premature death. ASD closure in elderly requires a thorough evaluation to ensure maximum benefit.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102930"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global magnitude and temporal trend of hypertensive heart disease burden attributable to high sodium intake from 1990 to 2021. 1990 年至 2021 年高钠摄入导致的高血压心脏病负担的全球规模和时间趋势。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102931

Yuanyuan Wang, Yanran Li, Zhaojia Lu, Zhengyan Li, Rui Wang, Zhengming Wang, Yong Gu, Liyun Chen

{"title":"The global magnitude and temporal trend of hypertensive heart disease burden attributable to high sodium intake from 1990 to 2021.","authors":"Yuanyuan Wang, Yanran Li, Zhaojia Lu, Zhengyan Li, Rui Wang, Zhengming Wang, Yong Gu, Liyun Chen","doi":"10.1016/j.cpcardiol.2024.102931","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102931","url":null,"abstract":"Background: The relationship between high sodium intake (HSI) and hypertensive heart disease (HHD) has been confirmed. However, notable regional disparities exist in implementing effective measures to control sodium intake. This study was carried out to estimate the spatiotemporal trends in the burden of HHD attributable to HSI.Methods: Data obtained from the Global Burden of Disease Study 2021 were analyzed, considering factors such as age, gender, year, and region. Joinpoint regression analysis was applied to investigate the temporal trends in the HHD burden resulting from HSI over the past 32 years.Results: From 1990 to 2021, the global cases of HHD increased significantly annually. The age-standardized prevalence rates showed a slow gradual increase. However, both the age-standardized death and disability-adjusted life-year (DALY) rates decreased. Specifically, HSI was responsible for 29.2% of total HHD deaths and 30.4% of total DALYs in 1990 but only 22.8% of total HHD deaths and 23.4% of total DALYs in 2021. A greater burden from HSI exposure was observed among men, older adults and people living in middle and low sociodemographic index (SDI) countries and regions. Moreover, over the 32-year period, Guam and Colombia demonstrated the highest reduction in age-standardized death and DALY rates, respectively.Conclusion: Globally, the age-standardized burden of HHD due to HSI has demonstrated a decline. Although some areas have effectively managed this issue, it remains a challenge in specific areas. Hence, it is crucial to examine and implement the strategies adopted by successful nations to further mitigate this burden.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102931"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right ventricular strain as a predictor of trastuzumab-induced chemotherapy-related cardiac dysfunction: A meta-analysis. 右心室应变作为曲妥珠单抗诱发化疗相关心功能障碍的预测指标：一项荟萃分析。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-09 DOI: 10.1016/j.cpcardiol.2024.102919

Hritvik Jain, Mushood Ahmed, Muhammad Daoud Tariq, Jyoti Jain, Aman Goyal, Ramez M Odat, Mayank Jha, Suchit Shashikumar, Isobel Scott, Raheel Ahmed

{"title":"Right ventricular strain as a predictor of trastuzumab-induced chemotherapy-related cardiac dysfunction: A meta-analysis.","authors":"Hritvik Jain, Mushood Ahmed, Muhammad Daoud Tariq, Jyoti Jain, Aman Goyal, Ramez M Odat, Mayank Jha, Suchit Shashikumar, Isobel Scott, Raheel Ahmed","doi":"10.1016/j.cpcardiol.2024.102919","DOIUrl":"10.1016/j.cpcardiol.2024.102919","url":null,"abstract":"Introduction: The survival rates of breast cancer patients have improved drastically in the past few decades due to advancements in anti-neoplastic drugs. Trastuzumab (TZ) chemotherapy is associated with left ventricular dysfunction leading to cardiotoxicity. Two-dimensional speckle-tracking echocardiography has demonstrated efficacy in predicting TZ-induced cardiotoxicity; however, its role in using right ventricular (RV) strain parameters remains unclear.Methods: A comprehensive literature search spanning major electronic databases was conducted to identify studies comparing pre- and post-TZ chemotherapy RV strain parameters. The outcomes of interest included RV global longitudinal strain (GLS) and RV free-wall longitudinal strain (FWLS). Mean differences (MD) with 95% confidence intervals (CI) were pooled using the inverse-variance random-effects model. Statistical significance was set at p<0.05.Results: Four studies involving 275 cancer patients were included. The mean age of the patients was 53.35 ± 11.1 years. The pooled analysis demonstrated significantly reduced RV GLS [MD: -1.94; 95% CI: -2.83, -1.05; p<0.01] and RV FWLS [MD: -2.05; 95% CI: -3.61, -0.50; p<0.01] on follow-up post-TZ chemotherapy compared to pre-TZ baseline values.Conclusion: Following TZ-based chemotherapy, RV subclinical damage ensues without overt clinical signs, leading to the deformation of RV mechanics. This meta-analysis demonstrated a reduction in RV GLS and RV FWLS after TZ-based chemotherapy.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102919"},"PeriodicalIF":3.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and in-hospital mortality among women with acute myocardial infarction with or without SCAD. 伴有或不伴有 SCAD 的急性心肌梗死女性患者的发病率和院内死亡率。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-09 DOI: 10.1016/j.cpcardiol.2024.102921

Chayakrit Krittanawong, Yusuf Kamran Qadeer, Song Peng Ang, Zhen Wang, Mahboob Alam, Samin Sharma, Hani Jneid

{"title":"Incidence and in-hospital mortality among women with acute myocardial infarction with or without SCAD.","authors":"Chayakrit Krittanawong, Yusuf Kamran Qadeer, Song Peng Ang, Zhen Wang, Mahboob Alam, Samin Sharma, Hani Jneid","doi":"10.1016/j.cpcardiol.2024.102921","DOIUrl":"10.1016/j.cpcardiol.2024.102921","url":null,"abstract":"Background: Spontaneous coronary artery dissection (SCAD) has been increasingly recognized in the past decades. SCAD patients can present with acute myocardial infarction (AMI), particularly in young healthy women without conventional risk factors. However, data on the outcomes of SCAD patients presenting with AMI or benefit of PCI for SCAD in the setting of AMI is inconclusive.Methods: We evaluated the prevalence, recent trends, the incidence and in-hospital mortality among women with acute myocardial infarction (AMI) who presented with or without SCAD, and to evaluate the impact of PCI on in-hospital mortality from a population-based analysis, using the National Inpatient Sample (NIS) database between 2016 and 2019.Results: From 2016-2019, there were 1,527,555 cases of females presenting with AMI. Of that number, there were 12,125 cases of SCAD. Mortality trends in the SCAD and non-SCAD group were comparable. There was a gradual increase in incidence each year for SCAD-STEMI.Conclusion: Mortality did not differ from 2016-2019 in patients with MI found to have SCAD or not. However, it seems that the SCAD-MI cases are gradually increasing each year. More research needs to be performed to better elucidate treatment outcomes in these patients.","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102921"},"PeriodicalIF":3.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of hypertension pharmacotherapy: Ongoing and future clinical trials for hypertension 高血压药物治疗的未来：正在进行的和未来的高血压临床试验。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-08 DOI: 10.1016/j.cpcardiol.2024.102922

Taha Mansoor MD , Fatima Farrukh MD , Subaina N. Khalid MD , Dmitry Abramov MD , Erin D. Michos MD, MHS , Anurag Mehta MD , Timir K. Paul MD, PhD , Sourbha S. Dani MD, MSc , Mahmoud Al Rifai MD , Arunima Misra MD , Vijay Nambi MD, PhD , Salim S. Virani MD, PhD , Abdul Mannan Khan Minhas MD, MS

{"title":"The future of hypertension pharmacotherapy: Ongoing and future clinical trials for hypertension","authors":"Taha Mansoor MD , Fatima Farrukh MD , Subaina N. Khalid MD , Dmitry Abramov MD , Erin D. Michos MD, MHS , Anurag Mehta MD , Timir K. Paul MD, PhD , Sourbha S. Dani MD, MSc , Mahmoud Al Rifai MD , Arunima Misra MD , Vijay Nambi MD, PhD , Salim S. Virani MD, PhD , Abdul Mannan Khan Minhas MD, MS","doi":"10.1016/j.cpcardiol.2024.102922","DOIUrl":"10.1016/j.cpcardiol.2024.102922","url":null,"abstract":"<div><div>Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review. We used clinicaltrials.gov to gather information about ongoing clinical trials of pharmacological hypertension therapy as of March 2024 and found 103 clinical trials that met our criteria. The interventions of these 103 clinical trials include novel and previously approved pharmacological and dietary supplement therapies for hypertension. We aim to use these clinical trials to provide insight into the future therapies and practices of hypertension treatment.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102922"},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic predisposition to acute lung injury in cardiac surgery ‘The VEGF Factor’: Review article and bibliometric analysis 心脏手术急性肺损伤的遗传易感性 "血管内皮生长因子因子"：评论文章和文献计量分析。

IF 3 3区医学

Current Problems in Cardiology Pub Date : 2024-11-06 DOI: 10.1016/j.cpcardiol.2024.102927

Wang Yabo PhD , Li Dongxu PhD , Li Xiao PhD , Bhushan Sandeep PhD , An Qi MD

{"title":"Genetic predisposition to acute lung injury in cardiac surgery ‘The VEGF Factor’: Review article and bibliometric analysis","authors":"Wang Yabo PhD , Li Dongxu PhD , Li Xiao PhD , Bhushan Sandeep PhD , An Qi MD","doi":"10.1016/j.cpcardiol.2024.102927","DOIUrl":"10.1016/j.cpcardiol.2024.102927","url":null,"abstract":"<div><div>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the most prevalent complications associated with cardiac surgery involving extracorporeal circulation (ECC), contributing to adverse outcomes and representing a significant impediment to successful cardiac surgical procedures. Vascular endothelial growth factor (VEGF) is implicated in the etiology of ALI/ARDS; however, its precise role remains a subject of debate due to the presence of somewhat contradictory findings in the literature, necessitating further investigation. To date, numerous studies have explored the role of VEGF in the pathophysiology of ALI/ARDS, with ongoing discussions regarding whether VEGF exerts a protective or detrimental effect. The genetic polymorphism of the VEGF gene is a significant factor in the development of ALI/ARDS. Research has indicated that the prevalence of the VEGF polymorphic gene is markedly higher in postoperative cardiac surgery patients who develop ALI/ARDS compared to the general population. Furthermore, the mortality rate among patients possessing the VEGF polymorphic gene is significantly elevated. Concurrently, it has been demonstrated that ARDS patients who are positive for the VEGF polymorphism exhibit a reduction in VEGF levels within alveolar lavage fluid, which correlates with an exacerbation of lung injury. The present paper provides a comprehensive review of the genetic polymorphisms of VEGF and their implications in the pathophysiological alterations observed in postoperative cardiac surgery patients with ALI/ARDS, thereby offering novel insights and evidence to further elucidate the mechanisms underlying ALI/ARDS.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102927"},"PeriodicalIF":3.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0