Current Problems in Cardiology最新文献

{"title":"High consumption of artificially sweetened beverages and associated risk of cardiovascular events: A systematic review and meta-analysis","authors":"Ivo Queiroz ,&nbsp;Maria L.R. Defante ,&nbsp;Arthur Tavares ,&nbsp;Vanio Antunes ,&nbsp;Cynthia Florencio de Mesquita ,&nbsp;Lucas M. Barbosa ,&nbsp;Beatriz Ximenes Mendes ,&nbsp;Angela S. Koh MBBS, MPH, PhD, FACC, FESC","doi":"10.1016/j.cpcardiol.2024.102837","DOIUrl":"10.1016/j.cpcardiol.2024.102837","url":null,"abstract":"<div><h3>Background</h3><div>With the rising use of artificial sweeteners as sugar substitutes, concerns regarding their impact on cardiovascular health have emerged. Artificially sweetened beverages are the primary source of diet sweeteners, but despite approval by national food agencies, evidence of their association with cardiovascular events has not been conclusive. Our Meta-Analysis assessed the relationship between artificially sweetened beverage consumption and long-term outcomes of cardiovascular events in extended follow-up cohorts.</div></div><div><h3>Methods</h3><div>Medline, Embase, and Cochrane databases were systematically searched for cohort studies investigating the incidence of all-cause mortality, cardiovascular mortality, stroke, and coronary heart disease among individuals with high consumption of ASB compared to minimal or no consumption. Pooled event hazard ratios with 95% confidence intervals were calculated using a random-effects model in R software, with heterogeneity assessed via I² statistics.</div></div><div><h3>Results</h3><div>We included twelve prospective cohorts comprising 1,224,560 patients. Analyses were conducted on patient groups with data adjusted for co-founding, such as dietary factors and comorbidities. One or more daily dose of Artificially sweetened beverages was significantly associated with a higher risk of all-cause mortality (HR 1.14; 95% 1.03 to 1.26; p &lt; 0.01;), Cardiovascular mortality (HR 1.29; 95% 1.1 to 1.53; p &lt; 0.01), and stroke (HR 1.15; 95% 1.01 to 1.32; p = 0.04;).</div></div><div><h3>Conclusion</h3><div>In this meta-analysis, we found a significant association between high consumption of ASBs and increased incidence of ACM, CVD, and stroke, highlighting potential long-term cardiovascular implications.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102837"},"PeriodicalIF":3.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right ventricular strain as a predictor of trastuzumab-induced chemotherapy-related cardiac dysfunction: A meta-analysis","authors":"Hritvik Jain MBBS ,&nbsp;Mushood Ahmed MBBS ,&nbsp;Muhammad Daoud Tariq MBBS ,&nbsp;Jyoti Jain MBBS ,&nbsp;Aman Goyal MBBS ,&nbsp;Ramez M. Odat MD ,&nbsp;Mayank Jha MBBS ,&nbsp;Suchit Shashikumar MBBS ,&nbsp;Isobel Scott MBChB ,&nbsp;Raheel Ahmed MBBS, MRCP","doi":"10.1016/j.cpcardiol.2024.102919","DOIUrl":"10.1016/j.cpcardiol.2024.102919","url":null,"abstract":"<div><h3>Introduction</h3><div>The survival rates of breast cancer patients have improved drastically in the past few decades due to advancements in anti-neoplastic drugs. Trastuzumab (TZ) chemotherapy is associated with left ventricular dysfunction leading to cardiotoxicity. Two-dimensional speckle-tracking echocardiography has demonstrated efficacy in predicting TZ-induced cardiotoxicity; however, its role in using right ventricular (RV) strain parameters remains unclear.</div></div><div><h3>Methods</h3><div>A comprehensive literature search spanning major electronic databases was conducted to identify studies comparing pre- and post-TZ chemotherapy RV strain parameters. The outcomes of interest included RV global longitudinal strain (GLS) and RV free-wall longitudinal strain (FWLS). Mean differences (MD) with 95% confidence intervals (CI) were pooled using the inverse-variance random-effects model. Statistical significance was set at p&lt;0.05.</div></div><div><h3>Results</h3><div>Four studies involving 275 cancer patients were included. The mean age of the patients was 53.35 ± 11.1 years. The pooled analysis demonstrated significantly reduced RV GLS [MD: -1.94; 95% CI: -2.83, -1.05; p&lt;0.01] and RV FWLS [MD: -2.05; 95% CI: -3.61, -0.50; p&lt;0.01] on follow-up post-TZ chemotherapy compared to pre-TZ baseline values.</div></div><div><h3>Conclusion</h3><div>Following TZ-based chemotherapy, RV subclinical damage ensues without overt clinical signs, leading to the deformation of RV mechanics. This meta-analysis demonstrated a reduction in RV GLS and RV FWLS after TZ-based chemotherapy.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102919"},"PeriodicalIF":3.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and in-hospital mortality among women with acute myocardial infarction with or without SCAD","authors":"Chayakrit Krittanawong MD, FACC ,&nbsp;Yusuf Kamran Qadeer MD ,&nbsp;Song Peng Ang MD ,&nbsp;Zhen Wang PhD ,&nbsp;Mahboob Alam MD, FACC ,&nbsp;Samin Sharma MD, FACC, MSCAI ,&nbsp;Hani Jneid MD, FACC, FSCAI","doi":"10.1016/j.cpcardiol.2024.102921","DOIUrl":"10.1016/j.cpcardiol.2024.102921","url":null,"abstract":"<div><h3>Background</h3><div>Spontaneous coronary artery dissection (SCAD) has been increasingly recognized in the past decades. SCAD patients can present with acute myocardial infarction (AMI), particularly in young healthy women without conventional risk factors. However, data on the outcomes of SCAD patients presenting with AMI or benefit of PCI for SCAD in the setting of AMI is inconclusive.</div></div><div><h3>Methods</h3><div>We evaluated the prevalence, recent trends, the incidence and in-hospital mortality among women with acute myocardial infarction (AMI) who presented with or without SCAD, and to evaluate the impact of PCI on in-hospital mortality from a population-based analysis, using the National Inpatient Sample (NIS) database between 2016 and 2019.</div></div><div><h3>Results</h3><div>From 2016-2019, there were 1,527,555 cases of females presenting with AMI. Of that number, there were 12,125 cases of SCAD. Mortality trends in the SCAD and non-SCAD group were comparable. There was a gradual increase in incidence each year for SCAD-STEMI.</div></div><div><h3>Conclusion</h3><div>Mortality did not differ from 2016-2019 in patients with MI found to have SCAD or not. However, it seems that the SCAD-MI cases are gradually increasing each year. More research needs to be performed to better elucidate treatment outcomes in these patients.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102921"},"PeriodicalIF":3.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of hypertension pharmacotherapy: Ongoing and future clinical trials for hypertension","authors":"Taha Mansoor MD ,&nbsp;Fatima Farrukh MD ,&nbsp;Subaina N. Khalid MD ,&nbsp;Dmitry Abramov MD ,&nbsp;Erin D. Michos MD, MHS ,&nbsp;Anurag Mehta MD ,&nbsp;Timir K. Paul MD, PhD ,&nbsp;Sourbha S. Dani MD, MSc ,&nbsp;Mahmoud Al Rifai MD ,&nbsp;Arunima Misra MD ,&nbsp;Vijay Nambi MD, PhD ,&nbsp;Salim S. Virani MD, PhD ,&nbsp;Abdul Mannan Khan Minhas MD, MS","doi":"10.1016/j.cpcardiol.2024.102922","DOIUrl":"10.1016/j.cpcardiol.2024.102922","url":null,"abstract":"<div><div>Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review. We used clinicaltrials.gov to gather information about ongoing clinical trials of pharmacological hypertension therapy as of March 2024 and found 103 clinical trials that met our criteria. The interventions of these 103 clinical trials include novel and previously approved pharmacological and dietary supplement therapies for hypertension. We aim to use these clinical trials to provide insight into the future therapies and practices of hypertension treatment.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102922"},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predisposition to acute lung injury in cardiac surgery ‘The VEGF Factor’: Review article and bibliometric analysis","authors":"Wang Yabo PhD ,&nbsp;Li Dongxu PhD ,&nbsp;Li Xiao PhD ,&nbsp;Bhushan Sandeep PhD ,&nbsp;An Qi MD","doi":"10.1016/j.cpcardiol.2024.102927","DOIUrl":"10.1016/j.cpcardiol.2024.102927","url":null,"abstract":"<div><div>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the most prevalent complications associated with cardiac surgery involving extracorporeal circulation (ECC), contributing to adverse outcomes and representing a significant impediment to successful cardiac surgical procedures. Vascular endothelial growth factor (VEGF) is implicated in the etiology of ALI/ARDS; however, its precise role remains a subject of debate due to the presence of somewhat contradictory findings in the literature, necessitating further investigation. To date, numerous studies have explored the role of VEGF in the pathophysiology of ALI/ARDS, with ongoing discussions regarding whether VEGF exerts a protective or detrimental effect. The genetic polymorphism of the VEGF gene is a significant factor in the development of ALI/ARDS. Research has indicated that the prevalence of the VEGF polymorphic gene is markedly higher in postoperative cardiac surgery patients who develop ALI/ARDS compared to the general population. Furthermore, the mortality rate among patients possessing the VEGF polymorphic gene is significantly elevated. Concurrently, it has been demonstrated that ARDS patients who are positive for the VEGF polymorphism exhibit a reduction in VEGF levels within alveolar lavage fluid, which correlates with an exacerbation of lung injury. The present paper provides a comprehensive review of the genetic polymorphisms of VEGF and their implications in the pathophysiological alterations observed in postoperative cardiac surgery patients with ALI/ARDS, thereby offering novel insights and evidence to further elucidate the mechanisms underlying ALI/ARDS.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102927"},"PeriodicalIF":3.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming pediatric heart failure: Efficacy of low-dose sacubitril/valsartan","authors":"Hui Zha ,&nbsp;Xuejia Zhai ,&nbsp;Lin Wang ,&nbsp;Quancheng Yang ,&nbsp;Qing Guo ,&nbsp;Yanyu Chen ,&nbsp;Jie Liu ,&nbsp;Hua Peng","doi":"10.1016/j.cpcardiol.2024.102926","DOIUrl":"10.1016/j.cpcardiol.2024.102926","url":null,"abstract":"<div><h3>Aims</h3><div>Pediatric heart failure is a significant cause of illness and death in children. We aimed to assess sacubitril/valsartan's effectiveness and find the proper dosage for pediatric patients.</div></div><div><h3>Methods</h3><div>Patients unresponsive to traditional medicines for at least 12 months prescribed sacubitril/valsartan from January 2020 to March 2023 were reviewed. The initial dose was 0.2 mg/kg bid, gradually increasing in 0.1 mg/kg increments. The target dose was determined based on blood pressure fluctuations at 70/50 mmHg. Clinical efficacy and quantity-effect relationship were evaluated using echocardiography, NT-proBNP, and the concentration of valsartan, sacubitril, sacubitrilat.</div></div><div><h3>Results</h3><div>A total of 23 pediatric patients with dilated cardiomyopathy and advanced heart failure were enrolled. Mean sacubitril/valsartan dose was 1.84 mg/kg/day. After 6 months, LVEF increased significantly (38.09% to 45% at 3 months, 52% at 6 months; <em>p</em> &lt; 0.001). LV size reduced to 4.4 cm (IQR, 4.1–5.2) and 4.5 cm (IQR, 4–5.1) at 3 and 6 months, respectively, from 4.6 cm (IQR, 4.2–5.6) at baseline (both <em>P</em> &lt; 0.05). NT-proBNP levels reduced by 5.7 at 3 months (<em>p</em> &lt; 0.05) and 5.38 at 6 months (<em>p</em> &lt; 0.001). Sacubitrilat is the active form of Sacubitril. The highest concentration of sacubitrilat was observed at approximately 1.6 mg/kg. The maintenance dose correlated positively with time (<em>p</em> &lt; 0.001) and valsartan/sacubitril concentration (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Low dose sacubitril/valsartan is effective in children with heart failure, with dosage adjustments to avoid hypotension. Adjusted dosing can increase EF and reduce heart size, offering new possibilities for pediatric heart failure treatment.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102926"},"PeriodicalIF":3.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between insulin resistance and cytokines in adolescents with excess of adiposity","authors":"Robinson Ramírez-Vélez ,&nbsp;María Correa-Rodríguez ,&nbsp;Juan Carlos Calderón-González ,&nbsp;Albeiro Dávila-Grisales ,&nbsp;Katherine González-Ruíz ,&nbsp;Jorge Enrique Correa-Bautista ,&nbsp;Mikel Izquierdo","doi":"10.1016/j.cpcardiol.2024.102925","DOIUrl":"10.1016/j.cpcardiol.2024.102925","url":null,"abstract":"<div><h3>Background and aims</h3><div>Increased adiposity has been directly associated with insulin resistance (IR), and cytokines released by adipose tissue seem to link adiposity to IR in youth. We used an antibody-based array to investigate the differential levels of serum cytokines according to insulin status in a cohort of overweight/obese and inactive adolescents and evaluated their potential associations with clinical and metabolic characteristics.</div></div><div><h3>Methods and results</h3><div>We performed a cross-sectional data analysis from 122 adolescents (11–17 years of age). We assessed body composition, cardiometabolic risk factors, biochemical variables, and physical fitness. The concentration of 55 cytokines was quantified in blood samples. The homeostasis model assessment insulin resistance (HOMA‐IR) and AST/ALT and TG/HDL ratios were calculated. IR adolescents as defined as HOMA-IR &gt;2.5. The number of adolescents with IR in the study was 91 (66 % girls). In the IS group, after controlling for confounders, higher IL-15 levels were significantly associated with higher alanine aminotransferase levels and lower AST/ALT ratio, respectively (<em>Ps</em>&lt;0.05). In the same line, there were significantly higher alanine aminotransferase levels and lower AST/ALT ratio, respectively, with FGF-9 (<em>Ps</em>&lt;0.05). Likewise, higher alanine aminotransferase levels were significantly associated positively with HGF (<em>p</em>=0.045). Additionally, leptin levels are associated with six adiposity indexes (i.e., fat mass/height index, body fat, body mass index, android fat mass and gynoid fat mass) in overweight/obese adolescents with IR (<em>Ps</em>&lt;0.05).</div></div><div><h3>Conclusions</h3><div>These data may provide novel insights into the pathogenic mechanisms underlying IR in youth, offering new targets for prevention.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102925"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and challenges of cardiac transplantation in the MENA region: A narrative review","authors":"Mohammad Tanashat ,&nbsp;Ahmed Zayed MD ,&nbsp;Mohammed Ayyad MD ,&nbsp;Mouath Abu Daoud ,&nbsp;Mohammad Tabbalat ,&nbsp;Obieda Altobaishat ,&nbsp;Jana Nusier ,&nbsp;F.N.U. Deepak ,&nbsp;Yazan A. Al-Ajlouni MD, MPhil","doi":"10.1016/j.cpcardiol.2024.102920","DOIUrl":"10.1016/j.cpcardiol.2024.102920","url":null,"abstract":"<div><h3>Introduction</h3><div>Cardiac transplantation has progressed markedly since 1967, with advances in immunosuppression, surgical techniques, and postoperative care that improve outcomes. However, challenges persist in the Middle East and North Africa (MENA) region due to unique cultural, economic, and infrastructural barriers. This review explores the status, innovations, and challenges of cardiac transplantation within MENA countries, comparing outcomes with global standards.</div></div><div><h3>Methodology</h3><div>A comprehensive literature search was conducted across PubMed, Web of Science, and Cochrane databases, including studies from inception to May 2024. Search terms targeted heart transplantation practices, challenges, and innovations in the MENA region. Articles not in English, non-human studies, and duplicates were excluded. Data extraction focused on patient demographics, transplantation outcomes, and barriers specific to the MENA context.</div></div><div><h3>Results</h3><div>Cardiac transplantation in MENA has made strides, with established programs in Saudi Arabia, the UAE, and Lebanon. Innovations like ex-vivo perfusion and Left Ventricular Assist Devices (LVAD) are improving transplant outcomes, yet organ shortages remain critical. Cultural and religious beliefs influence donation rates, and infrastructure varies widely, with disparities in healthcare resources across countries. Key barriers include low donor registration, inconsistent brain death definitions, and limited public awareness. Economic and infrastructure limitations further complicate access to advanced transplantation techniques.</div></div><div><h3>Conclusion</h3><div>While cardiac transplantation has evolved in MENA, significant barriers hinder widespread adoption. Enhancing public awareness, developing regional networks, and implementing standardized protocols can improve outcomes. Targeted immunosuppressive therapies and continued innovation in organ preservation are essential to advance cardiac transplantation in MENA.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102920"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of ST elevation myocardial infarction research from 1933 to 2023: Focus on top 100 most-cited articles","authors":"Siddig Ibrahim Abdelwahab ,&nbsp;Manal Mohamed Elhassan Taha ,&nbsp;Abdullah Farasani ,&nbsp;Ahmed Ali Jerah ,&nbsp;Saleh M Abdullah ,&nbsp;Bassem Oraibi ,&nbsp;Yasir Babiker ,&nbsp;Hassan Ahmad Alfaifi ,&nbsp;Amal Hamdan Alzahrani ,&nbsp;Ahmed S. Alamer ,&nbsp;Tawfeeq Altherwi ,&nbsp;Ibrahim Abdel Aziz Ibrahim ,&nbsp;Waseem Hassan","doi":"10.1016/j.cpcardiol.2024.102923","DOIUrl":"10.1016/j.cpcardiol.2024.102923","url":null,"abstract":"<div><div>The primary objective of this study was to conduct a bibliometric analysis of the most influential papers on ST-Elevation Myocardial Infarction (STEMI). Using the Scopus database (October 2024), a targeted search was performed to identify relevant publications. Three retrieval options were considered based on the appearance of search terms. Precisely those documents were analyzed where the search terms appeared only in the title, allowing for a focused analysis of the most directly relevant studies. Next, from this search, the top 100 most cited papers, spanning from 1981 to 2018, were selected for detailed examination. Data analysis was conducted using VOSviewer and R Studio to provide insights into publication trends, author productivity, and the thematic focus of STEMI research. Author performance was evaluated through various bibliometric indicators, including total publications (TP), total citations (TC), h-index, g-index, m-index, HG composite, and Q2 index. Key metrics such as mean total citations per article (MeanTCperArt) and mean annual citation rate (MeanTCperYear) were also calculated. Thematic analysis of research topics was conducted using unigrams, bigrams, and trigrams, highlighting primary areas of focus across the most impactful STEMI studies. The results underscore significant trends in STEMI research, with highly cited papers shaping the field's evolution. This bibliometric approach provides valuable insights into research patterns, major contributors, and prevalent themes within STEMI literature.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102923"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using different anthropometric indices of obesity as predictors for type 2 diabetes mellitus in older adults","authors":"Robinson Ramírez-Vélez ,&nbsp;Miguel A. Pérez-Sousa ,&nbsp;Emilio González-Jiménez ,&nbsp;María Correa-Rodríguez ,&nbsp;Juan Carlos Calderón-González ,&nbsp;Albeiro Dávila-Grisales ,&nbsp;Jacqueline Schmidt-RioValle","doi":"10.1016/j.cpcardiol.2024.102924","DOIUrl":"10.1016/j.cpcardiol.2024.102924","url":null,"abstract":"<div><h3>Background and aims</h3><div>There is some evidence that anthropometric measurements can be associated with the risk of type 2 diabetes mellitus (T2DM). Nevertheless, there is no comprehensive consensus on which anthropometric index is the best for evaluating the risk and predicting T2DM, especially in older adults. For this reason, we compared the performance of six indices for detecting T2DM in a population of Colombian older adults.</div></div><div><h3>Methods and results</h3><div>We conducted a cross-sectional study of 3453 older adults (≥60 years old; 2023 women), analysing demographic characteristics, biochemical markers, and anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), adiposity index (VAI), conicity index (C-Index), and body roundness index (BRI). T2DM was defined as fasting plasma glucose ≥126 mg/dl (≥7.0 mmol/l). All the anthropometric indices correlated significantly with the presence of T2DM. An analysis of the receiver operating characteristic curve showed that for men the VAI (AUC = 0.71; moderate ES (0.78); OR = 4.13), BMI (AUC = 0.68; moderate ES (0.68); OR = 3.38), and WC (AUC = 0.68; moderate ES (0.68); OR = 3.38) are the best predictors for identifying T2DM. For women, however, the WC (AUC = 0.63; ES = 0.46; OR = 2.34) and C-Index (AUC = 0.63; ES = 0.46; OR = 2.34) were better indicators for predicting T2DM. Cut-off points for all the anthropometric indices were provided.</div></div><div><h3>Conclusions</h3><div>In summary, the VAI, BMI, and WC in men, and WC and the C-Index in women have a moderate discriminating power for detecting T2DM in Colombian older adults, evidencing that these anthropometric indices are suitable screening tools for use in the elderly.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102924"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}