肥胖青少年和1型糖尿病青少年的比较脂质组学分析

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2025-01-17 DOI:10.1016/j.cpcardiol.2025.102991

Antonio García-Hermoso , Nidia Huerta-Uribe , Mikel Izquierdo , Katherine González-Ruíz , Jorge Enrique Correa-Bautista , Robinson Ramírez-Vélez

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引用次数: 0

摘要

目的：肥胖青少年和1型糖尿病（T1D）青少年都表现出脂质谱的改变，但直接比较有限。比较肥胖个体和T1D患者的脂质组学特征对于确定特定的代谢标志物、为这些不同人群提供量身定制的干预措施和推进精准医疗策略至关重要。该研究的目的是比较肥胖青少年和T1D青少年的脂质组学特征，并分析代谢物与临床参数之间的关系。方法：我们纳入了156名11-18岁的青少年（59.6%为女性），来自HEPAFIT （n=114，肥胖）和Diactive-1队列（n=42, T1D）研究。临床测量包括人体测量、身体成分、血脂、肝酶、葡萄糖和糖化血红蛋白。用UHPLC-MS对277例血清/血浆代谢物进行脂质组学分析。结果：肥胖组有明显的脂质特征，双甘油三酯、甘油三酯和某些磷脂酰肌醇较高，而磷脂酰胆碱、磷脂酰乙醇胺、胆固醇酯、鞘磷脂和神经酰胺在T1D中升高。甘油三酯酰基链长度和饱和水平也有所不同。多因素分析发现，7种代谢物PC（O-18:1/18:1）、PC（O-18:1/22:4）、PE（O-16:0/18:1）、PE（18:2e/22:6）、PC（40:1）、PC（O-22:1/20:4）和PE（P-18:0/18:1）与临床参数显著相关。结论：在该研究中，肥胖和T1D青少年中观察到不同的脂质谱，强调了了解特定代谢物与临床参数的关联对于更精确的健康管理的重要性。

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Comparative lipidomic profiling in adolescents with obesity and adolescents with type 1 diabetes

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Comparative lipidomic profiling in adolescents with obesity and adolescents with type 1 diabetes

Objective

Both adolescents with obesity and those with type 1 diabetes (T1D) exhibit alterations in lipid profiles, but direct comparisons are limited. Comparing lipidomic profiles between obese individuals and those with T1D is crucial for identifying specific metabolic markers, informing tailored interventions, and advancing precision medicine strategies for these distinct populations. The aim of the study was to compare lipidomic profiles between adolescents with obesity and those with T1D, and to analyze associations between metabolites and clinical parameters.

Methods

We included 156 adolescents aged 11–18 years (59.6% girls) from the HEPAFIT (n=114, obesity) and Diactive-1 Cohort (n=42, T1D) studies. Clinical measures included anthropometrics, body composition, lipids, liver enzymes, glucose, and HbA1c. Lipidomic analysis of 277 serum/plasma metabolites used UHPLC-MS.

Results

Distinct lipid profiles were seen, with higher diglycerides, triglycerides, and certain phosphatidylinositols in the obesity group, while phosphatidylcholines, phosphatidylethanolamines, cholesterol esters, sphingomyelins, and ceramides were elevated in T1D. Triglycerides acyl chain lengths and saturation levels also varied. Multivariate analysis identified seven metabolites –PC(O-18:1/18:1), PC(O-18:1/22:4), PE(O-16:0/18:1), PE(18:2e/22:6), PC(40:1), PC(O-22:1/20:4), and PE(P-18:0/18:1)– significantly associated with clinical parameters.

Conclusions

Distinct lipid profiles were observed among adolescents with obesity and T1D in the study, emphasizing the importance of understanding specific metabolite associations with clinical parameters for more precise health management.

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.