Current Problems in Cardiology最新文献

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IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00580-2
{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0146-2806(24)00580-2","DOIUrl":"10.1016/S0146-2806(24)00580-2","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102945"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor’s Message 编辑致辞
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-27 DOI: 10.1016/S0146-2806(24)00579-6
{"title":"Editor’s Message","authors":"","doi":"10.1016/S0146-2806(24)00579-6","DOIUrl":"10.1016/S0146-2806(24)00579-6","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 1","pages":"Article 102944"},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “HIV-Related Atherosclerosis: State-of-the-Art-Review” [Current Problems in Cardiology, Volume 48, Issue 9, September 2023, 101783] 与艾滋病毒相关的动脉粥样硬化:最新进展综述》[《心脏病学当前问题》,第 48 卷第 9 期,2023 年 9 月,101783] 更正
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-26 DOI: 10.1016/j.cpcardiol.2024.102928
Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Olga Urazova , Artem Trofimenko , Grizelda Navarsdyan , Zinaida Jndoyan , Kristina Abgaryan , Federica Fogacci , Mattia Galli , Luciano Agati , Zhanna Kobalava , Davood Shafie , Mario Marzilli , Liana Gogiashvili , Nizal Sarrafzadegan
{"title":"Corrigendum to “HIV-Related Atherosclerosis: State-of-the-Art-Review” [Current Problems in Cardiology, Volume 48, Issue 9, September 2023, 101783]","authors":"Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Olga Urazova , Artem Trofimenko , Grizelda Navarsdyan , Zinaida Jndoyan , Kristina Abgaryan , Federica Fogacci , Mattia Galli , Luciano Agati , Zhanna Kobalava , Davood Shafie , Mario Marzilli , Liana Gogiashvili , Nizal Sarrafzadegan","doi":"10.1016/j.cpcardiol.2024.102928","DOIUrl":"10.1016/j.cpcardiol.2024.102928","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102928"},"PeriodicalIF":3.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Polysocial Risk Score and CVH among Women of Reproductive Age in the SAFE HEART Study: An American Heart Association Research Goes Red Initiative: "Polysocial Risk and Cardiovascular Health in Women of Reproductive Age". SAFE HEART 研究中育龄妇女的多社会风险评分与心血管健康之间的关系:美国心脏协会 "红色研究计划":"育龄妇女的多社会风险与心血管健康"。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-25 DOI: 10.1016/j.cpcardiol.2024.102947
Faith E Metlock, Yaa Adoma Kwapong, Dhananjay Vaidya, Ketum Ateh Stanislas, Zulqarnain Javed, Pamela S Douglas, Khurram Nasir, Crystal Evans, Roxanne Mirabal-Beltran, Asma Rayani, Pamela Ouyang, Yvonne Commodore-Mensah, Garima Sharma
{"title":"Association between Polysocial Risk Score and CVH among Women of Reproductive Age in the SAFE HEART Study: An American Heart Association Research Goes Red Initiative: \"Polysocial Risk and Cardiovascular Health in Women of Reproductive Age\".","authors":"Faith E Metlock, Yaa Adoma Kwapong, Dhananjay Vaidya, Ketum Ateh Stanislas, Zulqarnain Javed, Pamela S Douglas, Khurram Nasir, Crystal Evans, Roxanne Mirabal-Beltran, Asma Rayani, Pamela Ouyang, Yvonne Commodore-Mensah, Garima Sharma","doi":"10.1016/j.cpcardiol.2024.102947","DOIUrl":"https://doi.org/10.1016/j.cpcardiol.2024.102947","url":null,"abstract":"<p><strong>Background: </strong>To assess the association between polysocial risk factors and cardiovascular health (CVH) among women of reproductive age.</p><p><strong>Methods: </strong>Our cross-sectional analysis included women of reproductive age (18-44 years) from community settings and the American Heart Association's Research Goes Red (RGR) registry. Polysocial risk scores (0-14) reflected social disadvantage across domains including socioeconomic stability (education, employment, income, insurance, financial strain), living situation (housing stability, housing quality, marital status, home ownership), food security, transportation, utilities, and interpersonal safety. Suboptimal CVH was defined as having ≥2 risk factors from Life's Essential 8 metrics: physical activity, diet, body mass index, sleep, smoking, blood pressure, blood sugar, and cholesterol. Associations between polysocial risk and suboptimal CVH were analyzed using linear regression models RESULTS: Suboptimal CVH increased with higher polysocial risk, from 77.0% in the lowest quartile to 95.2% in the highest. Participants in quartile 3 had the highest odds of suboptimal CVH (aOR 9.52, 95% CI 2.63-34.46), while quartile 4 showed decreased but significant odds (aOR 3.86, 95% CI 1.03-14.40) compared to quartile 1. Hypertension (aOR 10.23, 95% CI 3.61-29.01), diabetes (aOR 8.87, 95% CI 3.12-25.24), hyperlipidemia (aOR 7.48, 95% CI 2.72-20.55), and smoking (aOR 9.46, 95% CI 3.25-27.56) were strongly associated with higher polysocial risk in community-enrolled participants, whereas trends were less consistent in RGR-enrolled participants.</p><p><strong>Conclusions: </strong>Women with higher social risks face greater odds of suboptimal CVH. Screening for social determinants and tailored public health interventions are essential for mitigating CVH risks in this population.</p>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":" ","pages":"102947"},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and outcomes of concomitant cardiac amyloidosis and coronary artery disease 心脏淀粉样变性和冠状动脉疾病并发症的发病率和预后。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-24 DOI: 10.1016/j.cpcardiol.2024.102932
Koyenum Obi MD , Sahil Bharwani DO MPH , Vince Catalfamo MD , Antonio Duran MD , Harith Baldawi MD , Connor Gillies DO , Senthil Anand MBBS , James Wever-Pinzon MD , Clement Eiswirth MD , Sapna Desai MD , Selim Krim MD
{"title":"Prevalence and outcomes of concomitant cardiac amyloidosis and coronary artery disease","authors":"Koyenum Obi MD ,&nbsp;Sahil Bharwani DO MPH ,&nbsp;Vince Catalfamo MD ,&nbsp;Antonio Duran MD ,&nbsp;Harith Baldawi MD ,&nbsp;Connor Gillies DO ,&nbsp;Senthil Anand MBBS ,&nbsp;James Wever-Pinzon MD ,&nbsp;Clement Eiswirth MD ,&nbsp;Sapna Desai MD ,&nbsp;Selim Krim MD","doi":"10.1016/j.cpcardiol.2024.102932","DOIUrl":"10.1016/j.cpcardiol.2024.102932","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac amyloidosis (CA) and coronary artery disease (CAD) can have similar presentations in the acute care setting which can potentially delay the diagnosis of CA.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of patients referred to our institution for evaluation of cardiac amyloidosis. We obtained demographic and clinical characteristics, laboratory data, and echocardiographic measurements of those patients with confirmed cardiac amyloidosis. The population was divided into two groups based on the presence of CAD. Frequency of heart failure hospitalizations, and one-year overall mortality were compared between both groups.</div></div><div><h3>Results</h3><div>Between 2018 to 2021, 327 patients with suspected cardiac amyloidosis were referred to our institution. Out of 114 confirmed CA patients, 28 patients (25%) had concomitant CAD and CA. The overall mean age of CA diagnosis was 74.7 (±8.4) years for the CAD group and 69.7 (±9.8) for the non-CAD group (P value 0.002). Notably, a higher percentage of males were observed in the CAD group (92/.9% vs. 60%, p-value 0.002), and a higher prevalence of hypertension (92.9% vs 70%, p-value 0.018) and dyslipidemia (89.3% vs 59%, p-value 0.004) were also found in the CAD group. Overall, there were no significant differences in outcomes.</div></div><div><h3>Conclusion</h3><div>Larger studies are needed to identify characteristics that will result in a prompt diagnosis of CA in patients with concomitant CAD. Although our study did not appreciate a significant difference between these two groups, outcomes of our study were likely impacted by a small sample size in the CA with CAD cohort.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102932"},"PeriodicalIF":3.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal trends and disparities in atherosclerosis-associated cerebrovascular disease mortality in the United States, 1999-2020 1999-2020 年美国动脉粥样硬化相关脑血管疾病死亡率趋势的逆转。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-24 DOI: 10.1016/j.cpcardiol.2024.102935
Huzaifa Ul Haq Ansari MBBS , Eman Mahboob MBBS , Muhammad Ammar Samad MBBS , Maryam Shahzad MBBS , Mushood Ahmed MBBS , Syed Tabeer Hussain Naqvi MBBS , Shurjeel Uddin Qazi MBBS , Faizan Ahmed MD , Hollie Ross-Kenny MBBS , Muath Baniowda MD , Hina Farrukh MD , Raheel Ahmed
{"title":"Temporal trends and disparities in atherosclerosis-associated cerebrovascular disease mortality in the United States, 1999-2020","authors":"Huzaifa Ul Haq Ansari MBBS ,&nbsp;Eman Mahboob MBBS ,&nbsp;Muhammad Ammar Samad MBBS ,&nbsp;Maryam Shahzad MBBS ,&nbsp;Mushood Ahmed MBBS ,&nbsp;Syed Tabeer Hussain Naqvi MBBS ,&nbsp;Shurjeel Uddin Qazi MBBS ,&nbsp;Faizan Ahmed MD ,&nbsp;Hollie Ross-Kenny MBBS ,&nbsp;Muath Baniowda MD ,&nbsp;Hina Farrukh MD ,&nbsp;Raheel Ahmed","doi":"10.1016/j.cpcardiol.2024.102935","DOIUrl":"10.1016/j.cpcardiol.2024.102935","url":null,"abstract":"<div><h3>Background</h3><div>Cerebrovascular disease (CEVD) accounts for the second leading cause of death worldwide. Despite recent advancements in treatment strategies, the prevalence and cost associated with CEVD are rising. Atherosclerosis significantly contributes to CEVD risk by restricting cerebral blood flow, leading to ischemic stroke. This study aims to analyze trends in atherosclerosis-associated CEVD mortality in the United States from 1999 to 2020 to inform targeted prevention and management strategies.</div></div><div><h3>Methods</h3><div>We examined death certificates sourced from the CDC WONDER database, from 1999 to 2020 to identify atherosclerosis-associated CEVD mortality. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent changes were reported.</div></div><div><h3>Results</h3><div>A total of 325,401 deaths occurred from CEVD among adults with atherosclerosis from 1999 to 2020 in the US. The overall AAMR initially inclined from 10.9 in 1999 to 12.6 in 2001, followed by a decrease to 4.2 in 2016, and then a rise till 2020 was observed. Males had consistently higher AAMRs than females throughout the study period (Men = 11.9 vs Women = 10.1). When stratified by race, AAMRs were highest among non-Hispanic (NH) Whites (6.9), followed by NH American Indian/Alaska Native (10.9), NH Blacks/African Americans (6.6), Hispanics (4.9), and lastly by Asian/Pacific Islanders (4.2). The Western region had the highest mortality (AAMR: 7.7).</div></div><div><h3>Conclusion</h3><div>The CEVD mortality rates of adults with atherosclerosis- are increasing in the adult U.S. population. This underscores the need for increased screening, aggressive management, and subsequent surveillance of patients at risk.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102935"},"PeriodicalIF":3.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements, challenges, and innovative strategies in cardiac rehabilitation for patients with acute myocardial infarction: A systematic review 急性心肌梗死患者心脏康复的进展、挑战和创新策略:系统综述。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102934
Sisheng Zhang, Yuhui Lin
{"title":"Advancements, challenges, and innovative strategies in cardiac rehabilitation for patients with acute myocardial infarction: A systematic review","authors":"Sisheng Zhang,&nbsp;Yuhui Lin","doi":"10.1016/j.cpcardiol.2024.102934","DOIUrl":"10.1016/j.cpcardiol.2024.102934","url":null,"abstract":"<div><h3>Objects</h3><div>To synthesize current evidence on the impact of cardiac rehabilitation (CR) on acute myocardial infarction (AMI) patients, explore the barriers to effective CR delivery, and evaluate the potential of innovative strategies to enhance the reach and effectiveness of CR programs.</div></div><div><h3>Methods</h3><div>This systematic review analyzed literature from 2020–2024, focusing on advancements and challenges in CR for AMI patients. A comprehensive search strategy was applied using key terms \"cardiac rehabilitation\" and \"myocardial infarction,\" encompassing a variety of study designs.</div></div><div><h3>Results</h3><div>CR significantly improves cardiovascular outcomes in AMI patients, yet faces challenges including low participation rates and adherence issues. Innovative strategies, such as home-based rehabilitation and digital health interventions, have shown potential in enhancing patient engagement and outcomes.</div></div><div><h3>Conclusion</h3><div>CR is vital for AMI recovery but requires strategies to improve participation and adherence. Future research should focus on optimizing CR strategies to better serve the heart disease patient population. Technological advancements offer promising avenues for more personalized and accessible CR programs.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102934"},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking psoriasis to atrial fibrillation: Insights from "Association between psoriasis and atrial fibrillation: A systematic review and meta-analysis" 牛皮癣与心房颤动之间的关系:从 "牛皮癣与心房颤动之间的关系:从 "牛皮癣与心房颤动之间的关系 "中获得的启示":牛皮癣与心房颤动之间的关系 "的启示:系统回顾和荟萃分析":牛皮癣与心房颤动。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102933
Hong Zeng MD , Qi Shu MBBS , Jing Fang MD , Hailin Du MD , Ying Xue MD
{"title":"Linking psoriasis to atrial fibrillation: Insights from \"Association between psoriasis and atrial fibrillation: A systematic review and meta-analysis\"","authors":"Hong Zeng MD ,&nbsp;Qi Shu MBBS ,&nbsp;Jing Fang MD ,&nbsp;Hailin Du MD ,&nbsp;Ying Xue MD","doi":"10.1016/j.cpcardiol.2024.102933","DOIUrl":"10.1016/j.cpcardiol.2024.102933","url":null,"abstract":"<div><div>Patients with psoriasis indeed face an elevated risk of developing atrial fibrillation (AF), underscoring the need for vigilant monitoring to facilitate early detection and intervention. Given the current body of evidence linking psoriasis and AF is derived from observational studies, there is a clear need for more robust, multicenter, large-scale randomized studies. Such research would help to validate and reinforce the findings from observational data. Large-scale, randomized studies are necessary to confirm the association between psoriasis and AF, addressing potential biases and confounding factors present in observational research. Future studies should consider a broader range of factors that may influence the incidence of AF in psoriasis patients. This includes assessing the impact of AF \"burden,\" which could refer to the frequency, duration, or overall impact of AF episodes on patients' health. Research should delve into the role of genetic predispositions that may contribute to the development of AF in patients with psoriasis. The influence of smoking and lipid levels, among other lifestyle and environmental factors, should be examined for their potential effects on the incidence of AF in psoriasis patients. An interdisciplinary team, including dermatologists, cardiologists, and other healthcare professionals, should collaborate to provide comprehensive care for patients with psoriasis.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102933"},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcatheter or surgical aortic valve replacement in high-risk patients. Insights from a third-world country 高危患者接受经导管或外科主动脉瓣置换术。来自第三世界国家的启示。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-19 DOI: 10.1016/j.cpcardiol.2024.102936
Muddassir Syed Saleem, Nidal Bin Kamran , Hafsa Kaleem
{"title":"Transcatheter or surgical aortic valve replacement in high-risk patients. Insights from a third-world country","authors":"Muddassir Syed Saleem,&nbsp;Nidal Bin Kamran ,&nbsp;Hafsa Kaleem","doi":"10.1016/j.cpcardiol.2024.102936","DOIUrl":"10.1016/j.cpcardiol.2024.102936","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102936"},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention SIRT2 在心血管系统中的神秘作用:解密其保护性和破坏性作用,开辟治疗干预的新途径。
IF 3 3区 医学
Current Problems in Cardiology Pub Date : 2024-11-18 DOI: 10.1016/j.cpcardiol.2024.102929
Abdulaziz Hassan Alhasaniah , Mohammed Alissa , Fahmy Gad Elsaid , Mahdi H. Alsugoor , Mohammed S AlQahtani , Anwer Alessa , Khalid Jambi , Ghadah Shukri Albakri , Faisal Miqad K. Albaqami , Elizabeth Bennett
{"title":"The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention","authors":"Abdulaziz Hassan Alhasaniah ,&nbsp;Mohammed Alissa ,&nbsp;Fahmy Gad Elsaid ,&nbsp;Mahdi H. Alsugoor ,&nbsp;Mohammed S AlQahtani ,&nbsp;Anwer Alessa ,&nbsp;Khalid Jambi ,&nbsp;Ghadah Shukri Albakri ,&nbsp;Faisal Miqad K. Albaqami ,&nbsp;Elizabeth Bennett","doi":"10.1016/j.cpcardiol.2024.102929","DOIUrl":"10.1016/j.cpcardiol.2024.102929","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) are leading causes of mortality throughout the world, and hence, there is a critical need to elucidate their molecular mechanisms. The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated. However, the precise function of SIRT2 is only partially explored. Here, we review the current understanding of the involvement of SIRT2 in various cardiovascular pathologies, such as cardiac hypertrophy, ischemia-reperfusion injury, diabetic cardiomyopathy, and vascular dysfunction, with emphasis placed on the context-dependent protective or deleterious actions of SIRT2, including its wide array of catalytic activities which span beyond deacetylation. Furthermore, the review uncovers several unresolved research gaps for SIRT2 mechanisms by which SIRT2 modulates cardiac and vascular function during development and aging, thereby paving the way for the discovery of novel therapeutic targets as well as SIRT2-targeted interventions in the prevention and treatment of various cardiovascular diseases.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 2","pages":"Article 102929"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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