Current Problems in Cardiology最新文献

{"title":"HER2-targeted therapies and cardiotoxicity: From major concern to manageable risk","authors":"Rio Putra Pamungkas MD ,&nbsp;Laras Pratiwi MD ,&nbsp;Henry Sutanto MD, MSc, PhD","doi":"10.1016/j.cpcardiol.2025.103168","DOIUrl":"10.1016/j.cpcardiol.2025.103168","url":null,"abstract":"<div><div>HER2-targeted therapies have dramatically improved outcomes for patients with HER2-positive breast cancer, but their potential for cardiotoxicity remains a critical clinical concern. Early trials reported high rates of cardiac dysfunction, particularly with concomitant anthracycline use, prompting the development of intensive cardiac monitoring strategies. However, emerging evidence suggests that most cardiotoxic events are asymptomatic, reversible, and rarely require permanent treatment discontinuation, particularly with newer agents such as antibody–drug conjugates. Clinical determinants include baseline left ventricular dysfunction, age, comorbidities, and combination chemotherapy, while biomarkers and advanced imaging are promising tools for early detection. Mechanistically, HER2 inhibition disrupts cardiomyocyte survival pathways and mitochondrial function, but the relationship between these changes and clinically meaningful heart failure remains incompletely defined. Recent studies, including SAFE-HEaRt, demonstrate that HER2 therapy can often be safely continued under cardio-oncology supervision with appropriate cardioprotective interventions. Nevertheless, gaps persist in risk stratification, long-term surveillance, and the integration of biomarkers and imaging into routine practice. This article critically examines the pathophysiology, clinical risk factors, and management of HER2 therapy-induced cardiotoxicity, ultimately arguing that with proper monitoring and multidisciplinary care, cardiotoxicity should not preclude optimal oncologic treatment.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 11","pages":"Article 103168"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of 0.5 mg dose of colchicine on clinical outcomes in patients with acute myocardial infarction: An updated meta-analysis of randomized controlled trials","authors":"Ahmed Nazmy MD ,&nbsp;Ahmed Sobhy MD ,&nbsp;Ahmed Elshahat MD ,&nbsp;Karim Atta MD ,&nbsp;Mohamed R. Murad MD ,&nbsp;Moustafa Ibrahim MD ,&nbsp;Hassan El-Shirbiny MD ,&nbsp;Rahma Abdelfattah Ibrahim MD ,&nbsp;Mohamed Saad Sayed MD ,&nbsp;Mahmoud Gomaa MD ,&nbsp;Ahmed Yasser Shaban MD ,&nbsp;Mohamed Naeem MD ,&nbsp;Ahmed Abdelaziz MD","doi":"10.1016/j.cpcardiol.2025.103169","DOIUrl":"10.1016/j.cpcardiol.2025.103169","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation plays a critical role in the progression of atherosclerosis, and the anti-inflammatory effects on clinical outcomes of patients with acute myocardial infarction (AMI) are still uncertain.</div></div><div><h3>Objectives</h3><div>We aimed to study the effects of a 0.5 mg dose of colchicine on clinical outcomes following AMI.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Scopus, Web of Science, and Cochrane Central from inception to January 2025 for randomized controlled trials (RCTs) assessing 0.5 mg colchicine in AMI patients. The primary outcome was the incidence of major adverse cardiovascular events (MACE). Secondary outcomes included individual MACE components, cardiovascular (CV) and non-CV mortality, atrial fibrillation (AF), hospital readmission, and gastrointestinal (GIT) adverse events, including diarrhea.</div></div><div><h3>Results</h3><div>Ten RCTs involving 13,623 patients with a median follow-up of 6 months (range 5 days–36 months) were included. Low-dose colchicine showed a non-significant trend toward reducing MACE versus placebo (RR = 0.90, 95% CI: 0.80–1.01, p = 0.07; I² = 0%). Hospital readmission was significantly reduced by 49% (OR = 0.51, 95% CI: 0.26–0.98, p = 0.04; number needed to treat [NNT] = 25). Colchicine increased the risk of diarrhea (RR = 1.58, 95% CI: 1.06–2.36, p = 0.03; I² = 71%; number needed to harm [NNH] = 50) but showed no significant differences in all-cause mortality, CV mortality, myocardial infarction, stroke, or other GIT events.</div></div><div><h3>Conclusion</h3><div>Low-dose colchicine had a lower hospital readmission rate, but with higher rates of diarrhea compared to placebo. Long-term assessment is indeed to validate the current findings.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 11","pages":"Article 103169"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor’s Message","authors":"","doi":"10.1016/S0146-2806(25)00179-3","DOIUrl":"10.1016/S0146-2806(25)00179-3","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103159"},"PeriodicalIF":3.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0146-2806(25)00182-3","DOIUrl":"10.1016/S0146-2806(25)00182-3","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103162"},"PeriodicalIF":3.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0146-2806(25)00181-1","DOIUrl":"10.1016/S0146-2806(25)00181-1","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103161"},"PeriodicalIF":3.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S0146-2806(25)00178-1","DOIUrl":"10.1016/S0146-2806(25)00178-1","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103158"},"PeriodicalIF":3.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The top 100 most cited articles in cardiovascular research: A bibliometric perspective","authors":"Siddig Ibrahim Abdelwahab ,&nbsp;Manal Mohamed Elhassan Taha ,&nbsp;Abdullah Farasani ,&nbsp;Jobran M Moshi ,&nbsp;Ahmad Assiri ,&nbsp;Saeed Alshahrani ,&nbsp;Khaled A Sahli ,&nbsp;Hussam M. Shubaily ,&nbsp;Waseem Hassan","doi":"10.1016/j.cpcardiol.2025.103153","DOIUrl":"10.1016/j.cpcardiol.2025.103153","url":null,"abstract":"<div><h3>Objective</h3><div>The aim is to analyze the citation dynamics, and research focus of the top 100 most cited cardiovascular research.</div></div><div><h3>Methods</h3><div>Data were retrieved from the Scopus database in January 2025, focusing on journals containing the term “cardio” in their title. Only original research articles and reviews were included. The data were analyzed using VOSviewer and R Studio to assess co-authorship networks, keyword co-occurrence, citation mapping, and citation impact indicators.</div></div><div><h3>Results</h3><div>A total of 100 articles, published between 1967 and 2020, were included in the analysis. These articles had an average of 2,285 citations each. The growth rate of publications was 3.74 %, with an average document age of 20.8 years. Collaboration was extensive, with 1,653 authors contributing to these papers, and 25 % of publications involved international collaboration. Citation analysis showed increasing citation rates over time, with recent papers achieving significant impact in a short period. The top authors, universities, countries, and sources of publication were identified, revealing the global nature of cardiovascular research and its collaborative nature. The title co-words analysis was also performed to understand the main focus of the most cited papers.</div></div><div><h3>Conclusions</h3><div>This study offers a deeper understanding of the most cited cardiovascular research papers, addressing gaps in previous bibliometric studies by providing insights into citation dynamics, author collaborations, and thematic shifts. Future studies should explore the quality of research and expand the scope of bibliometric analyses.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 11","pages":"Article 103153"},"PeriodicalIF":3.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in cardiovascular risk in Peru: A 10-year population-based analysis (2015–2024)","authors":"Carlos Diaz-Arocutipa MD ,&nbsp;Natalia Nombera-Aznaran MD ,&nbsp;Vicente Benites-Zapata MD ,&nbsp;Pedro Kikushima-Alcantara MD ,&nbsp;Percy Herrera-Añazco MD","doi":"10.1016/j.cpcardiol.2025.103155","DOIUrl":"10.1016/j.cpcardiol.2025.103155","url":null,"abstract":"<div><h3>Background</h3><div>Data on national trends in cardiovascular risk in Latin America are limited. We aimed to evaluate changes in estimated 10-year cardiovascular risk in Peru between 2015 and 2024, and assess disparities by sex, age, residence, and region.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis using nationally representative data from the Peruvian Demographic and Health Survey. Adults aged 40–74 years with complete risk factor data were included. Ten-year cardiovascular risk was estimated using the 2019 WHO non-laboratory prediction charts for Andean Latin America. Trends in mean absolute risk and the proportion of individuals at ≥high risk were assessed using joinpoint regression models, overall and by sex, age group, area of residence, and region.</div></div><div><h3>Results</h3><div>Among 104,617 participants, mean estimated 10-year cardiovascular risk declined from 5% in 2015 to 4.4% in 2024 (average annual percent change [AAPC] −2.3%; 95% C: −3.2 to −1.5). The prevalence of ≥high cardiovascular risk decreased from 10.3% to 8.5% (AAPC −3.2%; 95% CI −5.0 to −1.6). Risk declined significantly among women, younger adults, and both urban and rural populations, but remained unchanged in men and older adults. Regional trends were heterogeneous, with the steepest reductions observed in Amazonas, Ica, and Ayacucho.</div></div><div><h3>Conclusions</h3><div>Although a slight decline in estimated cardiovascular risk was observed in Peru over the past decade, the change may have limited clinical relevance. These trends emphasize the need for stronger, equity-focused efforts to reduce the burden of cardiovascular disease at the national level.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103155"},"PeriodicalIF":3.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interatrial shunt devices in heart failure with preserved ejection fraction: A meta-analysis of randomized trials","authors":"Alonzo Armani Prata ,&nbsp;Ana Carolina Covre Coan ,&nbsp;Megan Coylewright MD, MPH ,&nbsp;Julia Marques Fernandes ,&nbsp;Eric Shih Katsuyama MD ,&nbsp;Christian Ken Fukunaga ,&nbsp;Gabriel Scarpioni Barbosa ,&nbsp;Pedro Gabriel Scardini ,&nbsp;Gioli-Pereira Luciana MD, PhD","doi":"10.1016/j.cpcardiol.2025.103154","DOIUrl":"10.1016/j.cpcardiol.2025.103154","url":null,"abstract":"<div><h3>Background</h3><div>The clinical effect of an iatrogenic interatrial shunt in heart failure with preserved ejection fraction (HFpEF) was based on observational data, wherein decompression of the pressure-overloaded left atrium improved symptoms and hemodynamics. However, the identification of a specific patient population that may benefit remains unclear.</div></div><div><h3>Methods</h3><div>We searched for randomized controlled trials (RCTs) that compared the creation of interatrial shunts versus a sham procedure in patients with HFpEF. The primary outcomes of interest were HF events and Cardiovascular (CV) mortality.</div></div><div><h3>Results</h3><div>Three RCTs were included, encompassing 966 patients, of which 479 (49.5%) were in the interatrial shunt group. The mean age of the participants was 73.2 years, with an average LVEF of 58.7%. Of the 479 patients undergoing interatrial shunt placement, 69% had exercise hemodynamics to assist in selection for therapy. Interatrial shunt therapy in the selected patients showed a trend towards an increased risk of HF events (RR:1.29;95%CI:0.98-1.70;p=0.069) and CV death (RR:2.30;95%CI:0.94-5.59;p=0.067), compared with the sham procedure.</div></div><div><h3>Conclusion</h3><div>In this meta-analysis of patients with HFpEF, interatrial shunt therapy showed a trend towards an increased risk of HF events and CV mortality compared with the sham procedure, with no significant improvement in MACE, quality of life, or rates of MI and stroke/TIA. These findings raise concerns about interatrial shunt therapy for the broader HFpEF population and highlight the need for better patient selection.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 11","pages":"Article 103154"},"PeriodicalIF":3.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripartum hypertension and neonatal outcomes across races: 2016-2022","authors":"Muhammad Shariq Usman MD ,&nbsp;Ali Salman MBBS ,&nbsp;Eliza Aisha MBBS ,&nbsp;Uzair Khan MBBS ,&nbsp;Sabina Naz MBBS ,&nbsp;Sarah Faisal MBBS ,&nbsp;Iqra Yaseen Khan MBBS ,&nbsp;Muhammad Hammad Arif MBBS ,&nbsp;Neha Mohiuddin MBBS ,&nbsp;Ayesha Ali Khan MBBS ,&nbsp;Ahson Afzal MBBS ,&nbsp;Hamza Janjua MD ,&nbsp;Farman Ali MD ,&nbsp;Tariq Jamal Siddiqi MD","doi":"10.1016/j.cpcardiol.2025.103152","DOIUrl":"10.1016/j.cpcardiol.2025.103152","url":null,"abstract":"<div><h3>Background</h3><div>Maternal hypertension, a major pregnancy complication, can adversely affect newborn health. Our study investigated racial/ethnic disparities in neonatal outcomes among hypertensive pregnant women in the US.</div></div><div><h3>Methods</h3><div>Using data from the CDC WONDER Natality database, we conducted a retrospective cohort study focusing on live births to hypertensive mothers from 2016 to 2022. We calculated rates [95% CI] per 1000 live births for NICU admissions, neonatal assisted ventilation, low birth weight, and in-hospital mortality across racial/ethnic groups and regions.</div></div><div><h3>Results</h3><div>We analyzed 2,392,664 live births to hypertensive women. In-hospital neonatal mortality rates were highest in Black American women (BA) (3.6 [3.5, 3.8]). Neonatal assisted ventilation rates were highest in Native Hawaiian/Pacific Islander women (NH/PI) (131.8 [123.4, 140.7]) and low birth weight rates were highest in BA (235.1 [233.9, 236.3]). Across all races, female neonates had a higher rate of low birth weight compared to male neonates, while male neonates had higher incidences of NICU admissions, neonatal assisted ventilation, and in-hospital mortality. The Midwest had the highest rates for NICU admissions in NH/PI (254.2 [217.2, 295.2]), neonatal assisted ventilation in American Indian/Alaska Native women (143.8 [133.2, 155.1]), and in-hospital mortality in BA (4.1 [3.7, 4.5]). The South had the highest rate of low birth weight for BA (244.4 [242.9, 246.0]).</div></div><div><h3>Conclusions</h3><div>Significant racial and regional disparities exist in neonatal outcomes among hypertensive women in the US, with BA mothers experiencing the poorest outcomes. Further research is necessary to develop targeted interventions for high-risk populations.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 10","pages":"Article 103152"},"PeriodicalIF":3.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}