发布求助
文献互助 智能选刊 最新文献

Advances in Genetics最新文献

筛选
英文 中文
Sleep regulation and host genetics. 睡眠调节与宿主遗传
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-04-08 DOI: 10.1016/bs.adgen.2024.02.002
Adrián Odriozola, Adriana González, Jesús Álvarez-Herms, Francesc Corbi
{"title":"Sleep regulation and host genetics.","authors":"Adrián Odriozola, Adriana González, Jesús Álvarez-Herms, Francesc Corbi","doi":"10.1016/bs.adgen.2024.02.002","DOIUrl":"10.1016/bs.adgen.2024.02.002","url":null,"abstract":"<p><p>Due to the multifactorial and complex nature of rest, we focus on phenotypes related to sleep. Sleep regulation is a multifactorial process. In this chapter, we focus on those phenotypes inherent to sleep that are highly prevalent in the population, and that can be modulated by lifestyle, such as sleep quality and duration, insomnia, restless leg syndrome and daytime sleepiness. We, therefore, leave in the background those phenotypes that constitute infrequent pathologies or for which the current level of scientific evidence does not favour the implementation of practical approaches of this type. Similarly, the regulation of sleep quality is intimately linked to the regulation of the circadian rhythm. Although this relationship is discussed in the sections that require it, the in-depth study of circadian rhythm regulation at the molecular level deserves a separate chapter, and this is how it is dealt with in this volume.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"111 ","pages":"497-535"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota-associated mechanisms in colorectal cancer. 结直肠癌的微生物相关机制。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-07-25 DOI: 10.1016/bs.adgen.2024.05.002
Adriana González, Asier Fullaondo, Adrian Odriozola
{"title":"Microbiota-associated mechanisms in colorectal cancer.","authors":"Adriana González, Asier Fullaondo, Adrian Odriozola","doi":"10.1016/bs.adgen.2024.05.002","DOIUrl":"https://doi.org/10.1016/bs.adgen.2024.05.002","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is one of the most common cancers worldwide, ranking third in terms of incidence and second as a cause of cancer-related death. There is growing scientific evidence that the gut microbiota plays a key role in the initiation and development of CRC. Specific bacterial species and complex microbial communities contribute directly to CRC pathogenesis by promoting the neoplastic transformation of intestinal epithelial cells or indirectly through their interaction with the host immune system. As a result, a protumoural and immunosuppressive environment is created conducive to CRC development. On the other hand, certain bacteria in the gut microbiota contribute to protection against CRC. In this chapter, we analysed the relationship of the gut microbiota to CRC and the associations identified with specific bacteria. Microbiota plays a key role in CRC through various mechanisms, such as increased intestinal permeability, inflammation and immune system dysregulation, biofilm formation, genotoxin production, virulence factors and oxidative stress. Exploring the interaction between gut microbiota and tumourigenesis is essential for developing innovative therapeutic approaches in the fight against CRC.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"112 ","pages":"123-205"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Techniques, procedures, and applications in microbiome analysis. 微生物组分析的技术、程序和应用。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1016/bs.adgen.2024.01.003
Adriana González, Asier Fullaondo, Adrián Odriozola
{"title":"Techniques, procedures, and applications in microbiome analysis.","authors":"Adriana González, Asier Fullaondo, Adrián Odriozola","doi":"10.1016/bs.adgen.2024.01.003","DOIUrl":"10.1016/bs.adgen.2024.01.003","url":null,"abstract":"<p><p>Microbiota is a complex community of microorganisms living in a defined environment. Until the 20th century, knowledge of microbiota was partial, as the techniques available for their characterization were primarily based on bacteriological culture. In the last twenty years, the development of DNA sequencing technologies, multi-omics, and bioinformatics has expanded our understanding of microorganisms. We have moved from mainly considering them isolated disease-causing agents to recognizing the microbiota as an essential component of host biology. These techniques have shown that the microbiome plays essential roles in various host phenotypes, influencing development, physiology, reproduction, and evolution. This chapter provides researchers with a summary of the primary concepts, sample collection, experimental techniques, and bioinformatics analysis commonly used in microbiome research. The main features, applications in microbiome studies, and their advantages and limitations are included in each section.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"111 ","pages":"81-115"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome and physical activity. 微生物组和体育锻炼
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-06-08 DOI: 10.1016/bs.adgen.2024.01.002
Jesús Álvarez-Herms, Adrián Odriozola
{"title":"Microbiome and physical activity.","authors":"Jesús Álvarez-Herms, Adrián Odriozola","doi":"10.1016/bs.adgen.2024.01.002","DOIUrl":"10.1016/bs.adgen.2024.01.002","url":null,"abstract":"<p><p>Regular physical activity promotes health benefits and contributes to develop the individual biological potential. Chronical physical activity performed at moderate and high-intensity is the intensity more favorable to produce health development in athletes and improve the gut microbiota balance. The athletic microbiome is characterized by increased microbial diversity and abundance as well as greater phenotypic versatility. In addition, physical activity and microbiota composition have bidirectional effects, with regular physical activity improving microbial composition and microbial composition enhancing physical performance. The improvement of physical performance by a healthy microbiota is related to different phenotypes: i) efficient metabolic development, ii) improved regulation of intestinal permeability, iii) favourable modulation of local and systemic inflammatory and efficient immune responses, iv) efective regulation of systemic pH and, v) protection against acute stressful events such as environmental exposure to altitude or heat. The type of sport, both intensity or volume characteristics promote microbiota specialisation. Individual assessment of the state of the gut microbiota can be an effective biomarker for monitoring health in the medium to long term. The relationship between the microbiota and the rest of the body is bidirectional and symbiotic, with a full connection between the systemic functions of the nervous, musculoskeletal, endocrine, metabolic, acid-base and immune systems. In addition, circadian rhythms, including regular physical activity, directly influence the adaptive response of the microbiota. In conclusion, regular stimuli of moderate- and high-intensity physical activity promote greater diversity, abundance, resilience and versatility of the gut microbiota. This effect is highly beneficial for human health when healthy lifestyle habits including nutrition, hydration, rest, chronoregulation and physical activity.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"111 ","pages":"409-450"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host genetics and nutrition. 宿主遗传和营养。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-04-25 DOI: 10.1016/bs.adgen.2024.03.001
Adrián Odriozola, Adriana González, Jesús Álvarez-Herms, Francesc Corbi
{"title":"Host genetics and nutrition.","authors":"Adrián Odriozola, Adriana González, Jesús Álvarez-Herms, Francesc Corbi","doi":"10.1016/bs.adgen.2024.03.001","DOIUrl":"10.1016/bs.adgen.2024.03.001","url":null,"abstract":"<p><p>Optimal nutrition is essential for health and physiological performance. Nutrition-related diseases such as obesity and diabetes are major causes of death and reduced quality of life in modern Western societies. Thanks to combining nutrigenetics and nutrigenomics, genomic nutrition allows the study of the interaction between nutrition, genetics and physiology. Currently, interrelated multi-genetic and multifactorial phenotypes are studied from a multiethnic and multi-omics approach, step by step identifying the important role of pathways, in addition to those directly related to metabolism. It allows the progressive identification of genetic profiles associated with specific susceptibilities to diet-related phenotypes, which may facilitate individualised dietary recommendations to improve health and quality of life.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"111 ","pages":"199-235"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota and other detrimental metabolites in colorectal cancer. 结直肠癌中的微生物群和其他有害代谢物。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1016/bs.adgen.2024.08.006
Adriana González, Asier Fullaondo, Iñaki Odriozola, Adrian Odriozola
{"title":"Microbiota and other detrimental metabolites in colorectal cancer.","authors":"Adriana González, Asier Fullaondo, Iñaki Odriozola, Adrian Odriozola","doi":"10.1016/bs.adgen.2024.08.006","DOIUrl":"https://doi.org/10.1016/bs.adgen.2024.08.006","url":null,"abstract":"<p><p>Increasing scientific evidence demonstrates that gut microbiota plays an essential role in the onset and development of Colorectal cancer (CRC). However, the mechanisms by which these microorganisms contribute to cancer development are complex and far from completely clarified. Specifically, the impact of gut microbiota-derived metabolites on CRC is undeniable, exerting both protective and detrimental effects. This paper examines the effects and mechanisms by which important bacterial metabolites exert detrimental effects associated with increased risk of CRC. Metabolites considered include heterocyclic amines and polycyclic aromatic hydrocarbons, heme iron, secondary bile acids, ethanol, and aromatic amines. It is necessary to delve deeper into the mechanisms of action of these metabolites in CRC and identify the microbiota members involved in their production. Furthermore, since diet is the main factor capable of modifying the intestinal microbiota, conducting studies that include detailed descriptions of dietary interventions is crucial. All this knowledge is essential for developing precision nutrition strategies to optimise a protective intestinal microbiota against CRC.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"112 ","pages":"309-365"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalised medicine based on host genetics and microbiota applied to colorectal cancer. 基于宿主遗传学和微生物群的个性化医疗应用于结直肠癌。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-09-27 DOI: 10.1016/bs.adgen.2024.08.004
Adriana González, Iker Badiola, Asier Fullaondo, Javier Rodríguez, Adrian Odriozola
{"title":"Personalised medicine based on host genetics and microbiota applied to colorectal cancer.","authors":"Adriana González, Iker Badiola, Asier Fullaondo, Javier Rodríguez, Adrian Odriozola","doi":"10.1016/bs.adgen.2024.08.004","DOIUrl":"https://doi.org/10.1016/bs.adgen.2024.08.004","url":null,"abstract":"<p><p>Colorectal cancer (CRC) ranks second in incidence and third in cancer mortality worldwide. This situation, together with the understanding of the heterogeneity of the disease, has highlighted the need to develop a more individualised approach to its prevention, diagnosis and treatment through personalised medicine. This approach aims to stratify patients according to risk, predict disease progression and determine the most appropriate treatment. It is essential to identify patients who may respond adequately to treatment and those who may be resistant to treatment to avoid unnecessary therapies and minimise adverse side effects. Current research is focused on identifying biomarkers such as specific mutated genes, the type of mutations and molecular profiles critical for the individualisation of CRC diagnosis, prognosis and treatment guidance. In addition, the study of the intestinal microbiota as biomarkers is being incorporated due to the growing scientific evidence supporting its influence on this disease. This article comprehensively addresses the use of current and emerging diagnostic, prognostic and predictive biomarkers in precision medicine against CRC. The effects of host genetics and gut microbiota composition on new approaches to treating this disease are discussed. How the gut microbiota could mitigate the side effects of treatment is reviewed. In addition, strategies to modulate the gut microbiota, such as dietary interventions, antibiotics, and transplantation of faecal microbiota and phages, are discussed to improve CRC prevention and treatment. These findings provide a solid foundation for future research and improving the care of CRC patients.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"112 ","pages":"411-485"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome-based precision nutrition: Prebiotics, probiotics and postbiotics. 基于微生物的精准营养：益生菌、益生菌和益后菌。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-05-11 DOI: 10.1016/bs.adgen.2024.04.001
Adrián Odriozola, Adriana González, Iñaki Odriozola, Jesús Álvarez-Herms, Francesc Corbi
{"title":"Microbiome-based precision nutrition: Prebiotics, probiotics and postbiotics.","authors":"Adrián Odriozola, Adriana González, Iñaki Odriozola, Jesús Álvarez-Herms, Francesc Corbi","doi":"10.1016/bs.adgen.2024.04.001","DOIUrl":"10.1016/bs.adgen.2024.04.001","url":null,"abstract":"<p><p>Microorganisms have been used in nutrition and medicine for thousands of years worldwide, long before humanity knew of their existence. It is now known that the gut microbiota plays a key role in regulating inflammatory, metabolic, immune and neurobiological processes. This text discusses the importance of microbiota-based precision nutrition in gut permeability, as well as the main advances and current limitations of traditional probiotics, new-generation probiotics, psychobiotic probiotics with an effect on emotional health, probiotic foods, prebiotics, and postbiotics such as short-chain fatty acids, neurotransmitters and vitamins. The aim is to provide a theoretical context built on current scientific evidence for the practical application of microbiota-based precision nutrition in specific health fields and in improving health, quality of life and physiological performance.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"111 ","pages":"237-310"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host genetics-associated mechanisms in colorectal cancer. 结直肠癌的宿主遗传相关机制。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-09-27 DOI: 10.1016/bs.adgen.2024.08.003
Adriana González, Asier Fullaondo, Adrian Odriozola
{"title":"Host genetics-associated mechanisms in colorectal cancer.","authors":"Adriana González, Asier Fullaondo, Adrian Odriozola","doi":"10.1016/bs.adgen.2024.08.003","DOIUrl":"https://doi.org/10.1016/bs.adgen.2024.08.003","url":null,"abstract":"<p><p>Colorectal cancer (CRC) represents the second leading cause of cancer incidence and the third leading cause of cancer deaths worldwide. There is currently a lack of understanding of the onset of CRC, hindering the development of effective prevention strategies, early detection methods and the selection of appropriate therapies. This article outlines the key aspects of host genetics currently known about the origin and development of CRC. The organisation of the colonic crypts is described. It discusses how the transformation of a normal cell to a cancer cell occurs and how that malignant cell can populate an entire colonic crypt, promoting colorectal carcinogenesis. Current knowledge about the cell of origin of CRC is discussed, and the two morphological pathways that can give rise to CRC, the classical and alternative pathways, are presented. Due to the molecular heterogeneity of CRC, each of these pathways has been associated with different molecular mechanisms, including chromosomal and microsatellite genetic instability, as well as the CpG island methylator phenotype. Finally, different CRC classification systems are described based on genetic, epigenetic and transcriptomic alterations, allowing diagnosis and treatment personalisation.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"112 ","pages":"83-122"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota and detrimental protein derived metabolites in colorectal cancer. 大肠癌中的微生物群和有害蛋白质衍生代谢物。
4区 生物学
Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-07-08 DOI: 10.1016/bs.adgen.2024.06.001
Adriana González, Iñaki Odriozola, Asier Fullaondo, Adrian Odriozola
{"title":"Microbiota and detrimental protein derived metabolites in colorectal cancer.","authors":"Adriana González, Iñaki Odriozola, Asier Fullaondo, Adrian Odriozola","doi":"10.1016/bs.adgen.2024.06.001","DOIUrl":"https://doi.org/10.1016/bs.adgen.2024.06.001","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is the third leading cancer in incidence and the second leading cancer in mortality worldwide. There is growing scientific evidence to support the crucial role of the gut microbiota in the development of CRC. The gut microbiota is the complex community of microorganisms that inhabit the host gut in a symbiotic relationship. Diet plays a crucial role in modulating the risk of CRC, with a high intake of red and processed meat being a risk factor for the development of CRC. The production of metabolites derived from protein fermentation by the gut microbiota is considered a crucial element in the interaction between red and processed meat consumption and the development of CRC. This paper examines several metabolites derived from the bacterial fermentation of proteins associated with an increased risk of CRC. These metabolites include ammonia, polyamines, trimethylamine N-oxide (TMAO), N-nitroso compounds (NOC), hydrogen sulphide (H<sub>2</sub>S), phenolic compounds (p-cresol) and indole compounds (indolimines). These compounds are depicted and reviewed for their association with CRC risk, possible mechanisms promoting carcinogenesis and their relationship with the gut microbiota. Additionally, this paper analyses the evidence related to the role of red and processed meat intake and CRC risk and the factors and pathways involved in bacterial proteolytic fermentation in the large intestine.</p>","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"112 ","pages":"255-308"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信