Advances in Genetics最新文献

The implication of lncRNAs in the regulation of inflammation. lncrna在炎症调节中的意义。

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1016/bs.adgen.2025.11.006

Izei Pascual-González, Henar Rojas-Márquez

引用次数: 0

The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic target. 炎症和自身免疫性疾病中的JAK-STAT信号通路：其作为治疗靶点的潜在作用

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/bs.adgen.2025.11.008

Leire Bergara-Muguruza, Kaan Gundogdu, Izortze Santin

引用次数: 0

Long noncoding RNAs as key regulators of autoimmunity. 长链非编码rna作为自身免疫的关键调控因子。

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2025-12-27 DOI: 10.1016/bs.adgen.2025.11.005

Ruxiao Yang-Fischer, Alyssa Shearer, Sankar Ghosh

引用次数: 0

IFN response regulation upon viral infections. 干扰素对病毒感染的反应调节。

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2026-01-08 DOI: 10.1016/bs.adgen.2025.11.007

Carolina Chiale

{"title":"IFN response regulation upon viral infections.","authors":"Carolina Chiale","doi":"10.1016/bs.adgen.2025.11.007","DOIUrl":"10.1016/bs.adgen.2025.11.007","url":null,"abstract":"Interferons are key mediators of antiviral defense. They enable infected cells and specialized immune populations to mount rapid transcriptional responses that restrict viral replication and support immune activation. Type I and type III interferons share many antiviral properties, but their effects are determined by distinct receptor distributions, signaling dynamics, and tissue localization. While both families contribute to protection against infection, this chapter focuses primarily on the regulation and function of type I interferons. The induction of interferons depends on the activation of pattern recognition receptors that detect viral nucleic acids and trigger signaling cascades involving IRF and NF-κB transcription factors. These pathways control tightly regulated transcriptional and epigenetic programs that drive interferon gene expression and the induction of interferon-stimulated genes. Balanced regulation is essential, as excessive or persistent signaling can cause immunopathology and chronic inflammation. Genetic variation in interferon pathways influences susceptibility to viral infections, and defects in interferon regulation contribute to several monogenic interferonopathies. Plasmacytoid dendritic cells are a major source of type I interferons and illustrate the complexity of cellular specialization in antiviral defense. Understanding these mechanisms is essential for the development of therapies that enhance antiviral protection or limit pathogenic inflammation in chronic infections and autoimmune disease.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"115 ","pages":"189-228"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokines and their receptors: The importance of their expression for an appropriate regulation of the immune response in health and disease. 趋化因子及其受体：其表达对健康和疾病中免疫反应的适当调节的重要性。

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/bs.adgen.2025.11.010

Maialen Sebastian-delaCruz

{"title":"Chemokines and their receptors: The importance of their expression for an appropriate regulation of the immune response in health and disease.","authors":"Maialen Sebastian-delaCruz","doi":"10.1016/bs.adgen.2025.11.010","DOIUrl":"10.1016/bs.adgen.2025.11.010","url":null,"abstract":"Leukocytes are typically migratory immune cells, and their migration is of critical immunological importance. In this context, chemokines and their receptors play a dynamic role in regulating the functions of leukocytes within the immune system, since they drive leukocytes into and out of blood and lymphatic vessels and direct their interstitial movement and positioning. Chemokines constitute a large family of cytokines that primarily regulate immune cell migration through the binding to chemokine receptors expressed on the surface of leukocytes. They are expressed by both immune and non-immune cells, and their activity is tightly regulated at several levels from transcription to secretion and distribution. Conventional chemokine receptors are G protein-coupled receptors (GPCR) found mainly in immune cells that can modulate the immune response activation by the initiation of a signaling cascade. On the contrary, atypical chemokine receptors act as decoy receptors and regulate chemokine levels in the blood. Together, chemokines and their receptors form the chemokine system, a complex network with high redundance and promiscuity. Dysregulation of this system can contribute to various disorders that have an immune or inflammatory component mediated by chemokine-directed leukocyte migration, such as chronic inflammatory and neurodegenerative disorders. Thus, in this chapter I focused on the role of chemokines and their receptors under physiological conditions and on their implication in disorders like multiple sclerosis, Parkinson's Disease and Alzheimer's Disease, in which neuroinflammation caused by the infiltration of these immune cells into the CNS and their activation plays a key role in the development of the pathologies.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"115 ","pages":"279-363"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genetic regulation of immune cells upon activation. 免疫细胞激活后的遗传调控。

4区生物学

Advances in Genetics Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1016/bs.adgen.2025.11.009

Rodrigo Sánchez-Tarjuelo

{"title":"The genetic regulation of immune cells upon activation.","authors":"Rodrigo Sánchez-Tarjuelo","doi":"10.1016/bs.adgen.2025.11.009","DOIUrl":"10.1016/bs.adgen.2025.11.009","url":null,"abstract":"Recent discoveries in the field of epigenetic regulation have shed light on the intricate processes of immune cell activation, differentiation, and function in response to threats. Epigenetics connects genetic and environmental factors and includes DNA methylation, histone post-translational modifications and the regulation of chromatin accessibility by non-coding RNAs controlling constitutive or inducible gene transcription. These mechanisms coordinate the activation or suppression of immune cells via specific transcriptional programmes. In particular, epigenetic marks at the sites of lineage-specific transcription factors, as well as the maintenance of cell-type-specific epigenetic modifications, dictate cell differentiation, cytokine production and functional ability following repeated exposure to antigens in memory T cells. Furthermore, the epigenetic and metabolic reprogramming that occurs during a primary innate immune response, results in enhanced responses to secondary challenges. A complete understanding of the epigenetic basis of immune cell differentiation and cellular stability will clarify pathological dysregulation and help delineate new therapeutic strategies for targeting immune disorders.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"115 ","pages":"1-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic underpinnnings of type 2 diabetes. 2型糖尿病的遗传基础。

4区生物学

Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.adgen.2024.12.001

Aditya Shah, Clancy O Bush, Rachel J Perry

{"title":"Genetic underpinnnings of type 2 diabetes.","authors":"Aditya Shah, Clancy O Bush, Rachel J Perry","doi":"10.1016/bs.adgen.2024.12.001","DOIUrl":"10.1016/bs.adgen.2024.12.001","url":null,"abstract":"Genetics is a significant risk factor for developing type 2 diabetes, with a family history conferring a 1.5-3-fold increased risk. Intriguingly, this heritable risk is higher when the affected parent is the mother, suggesting a potential role of mitochondrial genetics -maternally inherited DNA - in diabetes pathogenesis, a hypothesis this chapter will explore. While obesity mediates some of the genetic risk of type 2 diabetes, the chapter and will focus on genetic influences on diabetes independent of obesity. Mechanistically, genetic variants directly or indirectly contribute to insulin resistance across key tissues, including liver, muscle and adipose tissue. This insulin resistance prevents the liver from efficiently suppressing glucose production in response to insulin and impairs glucose uptake in muscle during postprandial states. Insulin resistance is driven by complex interactions between the genome and environmental, which can, in turn, influence gene expression and contribute to worsening of metabolic dysfunction. This chapter examines how tissue-specific genetic changes drive insulin resistance in individual organs and how these localized dysfunctions contribute to the broader, multi-organ metabolic dysfunction that characterize type 2 diabetes.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"113 ","pages":"54-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal physiology in metabolic syndrome. 代谢综合征的视网膜生理学。

4区生物学

Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2025-02-05 DOI: 10.1016/bs.adgen.2024.11.002

David Meseguer García

引用次数: 0

Crosstalk between T cell gene regulation and intestinal epithelial cells: Insights into mucosal immunity. T细胞基因调控与肠上皮细胞间的串扰：对粘膜免疫的认识。

4区生物学

Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1016/bs.adgen.2025.03.002

Dora Bordoni, Antonella Fazio

{"title":"Crosstalk between T cell gene regulation and intestinal epithelial cells: Insights into mucosal immunity.","authors":"Dora Bordoni, Antonella Fazio","doi":"10.1016/bs.adgen.2025.03.002","DOIUrl":"10.1016/bs.adgen.2025.03.002","url":null,"abstract":"The intestinal epithelium serves as a critical mechanical barrier against potentially pathogenic bacteria and their antigens while maintaining immune homeostasis and facilitating nutrient and water absorption. In the gut, T cells undergo a multitude of highly specialized differentiation processes which are influenced by the unique microenvironment. Several studies reveal that intestinal epithelial cells (IECs) not only provide signals that shape T cell responses but also express a variety of factors that modulate T cell activity, such as cytokines, chemokines, and antigen-presenting molecules. The crosstalk between T cells and intestinal epithelium is necessary to grant a delicate immune balance to prevent excessive inflammation while assuring tolerance towards commensal microbial communities. Disruption of this line of communication can be deleterious since it could lead to immune-inflammatory disorders such as inflammatory bowel disease (IBD) and other disorders such as colorectal cancer. In recent years, advanced genomic and transcriptomic technologies have partially untangled the regulatory networks underlying this interaction. Understanding how the mechanisms governing the regulation of the interaction between T cells and IECs offers potential therapeutic hints for enhancing mucosal immunity and treating related diseases affecting gastrointestinal health. This chapter explores the key cellular players of mucosal immunity and the importance of epithelial-T cell interactions for immune regulation and potential therapeutic applications.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"114 ","pages":"23-65"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

4区生物学

Advances in Genetics Pub Date : 2025-01-01 DOI: 10.1016/S0065-2660(25)00026-4

引用次数: 0