Parkinson's disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system.

4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2025-03-06 DOI:10.1016/bs.adgen.2025.02.001
Thanh N Pham, Rebecca E Schelling, Ken H Loh
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引用次数: 0

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor dysfunctions. Its pathological hallmark is the aggregation of ɑ-synuclein in the central nervous system (CNS), leading to widespread loss of dopaminergic neurons in the substantia nigra (SN). Interestingly, metabolic disorders localized in the periphery, such as diabetes mellitus, frequently co-occur with PD. Emerging evidence highlights a bidirectional relationship: metabolic diseases may accelerate PD progression, while PD can exacerbate metabolic dysfunction. Beyond these associations, a growing body of research suggests that dysfunction in the peripheral nervous system, the primary communication bridge between the brain and peripheral organs, plays a critical role in these comorbidities. Autonomic nerve perturbation may accelerate dopaminergic neuronal loss in the SN and exacerbate metabolic dysregulation. This chapter synthesizes current evidence linking autonomic dysfunction with the progression of PD and related metabolic disorders, and it explores innovative therapeutic strategies leveraging this bidirectional relationship to address PD progression.

帕金森氏病和代谢性疾病,通过自主神经系统了解它们的共同发病率。
帕金森病(PD)是一种以运动和非运动功能障碍为特征的进行性神经退行性疾病。其病理特征是中枢神经系统(CNS)中突触核蛋白的聚集,导致黑质(SN)多巴胺能神经元的广泛丧失。有趣的是,周围的代谢性疾病,如糖尿病,经常与PD同时发生。新出现的证据强调了一种双向关系:代谢性疾病可能加速PD的进展,而PD可能加剧代谢功能障碍。除了这些关联之外,越来越多的研究表明,作为大脑和外周器官之间主要沟通桥梁的外周神经系统的功能障碍在这些合并症中起着关键作用。自主神经的扰动可能会加速SN中多巴胺能神经元的丢失,加剧代谢失调。本章综合了目前将自主神经功能障碍与帕金森病和相关代谢紊乱的进展联系起来的证据,并探索了利用这种双向关系来解决帕金森病进展的创新治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in Genetics
Advances in Genetics 生物-遗传学
CiteScore
5.70
自引率
0.00%
发文量
1
审稿时长
1 months
期刊介绍: Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
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