代谢综合征的视网膜生理学。

4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2025-02-05 DOI:10.1016/bs.adgen.2024.11.002
David Meseguer García
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引用次数: 0

摘要

人们越来越认识到,肥胖不仅对全身健康有影响,而且还与视力缺陷和眼病有关。本章探讨肥胖和眼健康之间的关系,强调代谢失调影响视力结果的机制。肥胖会加剧高血压、血脂异常和胰岛素抵抗等危险因素,损害视网膜和视神经的健康。糖尿病视网膜病变、年龄相关性黄斑变性和青光眼等疾病在肥胖相关炎症、氧化应激和血管功能改变的背景下进行了讨论,重点关注视网膜作为人体最需要代谢的组织之一。关键途径包括脂肪来源的细胞因子破坏视网膜稳态,胰岛素抵抗对视网膜细胞和脉管系统的影响。此外,本章还涵盖了将糖尿病视网膜病变与视网膜损伤联系起来的遗传因素的最新进展证据。通过阐明这些相互作用,我们的目标是提供预防和治疗策略,以减轻肥胖患者的视力丧失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinal physiology in metabolic syndrome.

Obesity is increasingly recognized not only for its systemic health impacts but also for its association with visual defects and eye diseases. This chapter explores the relationship between obesity and ocular health, highlighting the mechanisms by which metabolic dysregulation influences visual outcomes. Obesity exacerbates risk factors such as hypertension, dyslipidemia, and insulin resistance, which compromise retinal and optic nerve health. Conditions like diabetic retinopathy, age-related macular degeneration, and glaucoma are discussed in the context of obesity-related inflammation, oxidative stress, and altered vascular function, focusing on the retina as one of the body's most metabolically demanding tissues. Key pathways include adipose-derived cytokines that disrupt retinal homeostasis, and the effects of insulin resistance on retinal cells and vasculature. Furthermore, this chapter covers emerging evidence on the advances of genetic factors linking diabetic retinopathy to retinal impairments. By elucidating these interactions, we aim to provide insight into preventive and therapeutic strategies that could mitigate vision loss among individuals with obesity.

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来源期刊
Advances in Genetics
Advances in Genetics 生物-遗传学
CiteScore
5.70
自引率
0.00%
发文量
1
审稿时长
1 months
期刊介绍: Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
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