Genomic predictors of physical activity and athletic performance.

4区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in Genetics Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI:10.1016/bs.adgen.2024.01.001

Ildus I Ahmetov, George John, Ekaterina A Semenova, Elliott C R Hall

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Abstract

Physical activity and athletic performance are complex phenotypes influenced by environmental and genetic factors. Recent advances in lifestyle and behavioral genomics led to the discovery of dozens of DNA polymorphisms (variants) associated with physical activity and allowed to use them as genetic instruments in Mendelian randomization studies for identifying the causal links between physical activity and health outcomes. On the other hand, exercise and sports genomics studies are focused on the search for genetic variants associated with athlete status, sports injuries and individual responses to training and supplement use. In this review, the findings of studies investigating genetic markers and their associations with physical activity and athlete status are reported. As of the end of September 2023, a total of 149 variants have been associated with various physical activity traits (of which 42 variants are genome-wide significant) and 253 variants have been linked to athlete status (115 endurance-related, 96 power-related, and 42 strength-related).

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体力活动和运动成绩的基因组预测因素。

体育锻炼和运动成绩是受环境和遗传因素影响的复杂表型。生活方式和行为基因组学的最新进展导致发现了数十种与体育锻炼相关的 DNA 多态性（变异），并将其作为孟德尔随机研究的遗传工具，以确定体育锻炼与健康结果之间的因果关系。另一方面，运动和体育基因组学研究的重点是寻找与运动员状态、运动损伤以及个人对训练和补充剂使用的反应相关的基因变异。本综述报告了对遗传标记及其与体育锻炼和运动员状态的关系的研究结果。截至 2023 年 9 月底，共有 149 个变体与各种体力活动特征相关（其中 42 个变体具有全基因组意义），253 个变体与运动员状态相关（115 个与耐力相关，96 个与力量相关，42 个与力量相关）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Genetics 生物-遗传学

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.