From metabolomics to energy balance physiology.

4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Advances in Genetics Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI:10.1016/bs.adgen.2024.11.001
María José Ortuño Romero, Daxiang Na
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引用次数: 0

Abstract

Omics technologies are transforming our understanding of disease mechanisms and reshaping clinical practice. By enabling high-throughput, unbiased data collection at various molecular levels - including genes (genomics), mRNA (transcriptomics), proteins (proteomics), and metabolites (metabolomics) - omics approaches offer a comprehensive view of biological states in both health and disease. Among these, metabolomics has emerged as a pivotal tool, rapidly evolving beyond diagnostics to become a cutting-edge technique for pinpointing metabolites that regulate key physiological processes. This chapter reviews the advances in metabolomics, its integration with other omics approaches, and its applications, particularly emphasizing energy homeostasis. By incorporating metabolomic insights into physiology, we move closer to an integrative understanding of biological systems, laying the groundwork for novel therapies to combat obesity and related metabolic disorders.

从代谢组学到能量平衡生理学。
组学技术正在改变我们对疾病机制的理解,重塑临床实践。通过在各种分子水平(包括基因(基因组学)、mRNA(转录组学)、蛋白质(蛋白质组学)和代谢物(代谢组学))上实现高通量、无偏倚的数据收集,组学方法提供了健康和疾病生物状态的全面视图。其中,代谢组学已经成为一种关键工具,迅速发展成为一种尖端技术,用于精确定位调节关键生理过程的代谢物。这一章回顾了代谢组学的进展,它与其他组学方法的整合,以及它的应用,特别强调能量稳态。通过将代谢组学的见解纳入生理学,我们更接近于对生物系统的综合理解,为对抗肥胖和相关代谢紊乱的新疗法奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in Genetics
Advances in Genetics 生物-遗传学
CiteScore
5.70
自引率
0.00%
发文量
1
审稿时长
1 months
期刊介绍: Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
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