American Journal of Alzheimers Disease and Other Dementias最新文献

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Evaluation of Cognitive Functions of Individuals Older Than 65 With Diagnosis of Diabetes. 评估 65 岁以上确诊糖尿病患者的认知功能。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-09-27 DOI: 10.1177/1533317518802453
Serap Gokce, Canan Demir Barutcu
{"title":"Evaluation of Cognitive Functions of Individuals Older Than 65 With Diagnosis of Diabetes.","authors":"Serap Gokce, Canan Demir Barutcu","doi":"10.1177/1533317518802453","DOIUrl":"10.1177/1533317518802453","url":null,"abstract":"<p><p>This study was conducted in order to examine the level of cognitive function of individuals ≥65 years of age with diabetes. The cross-sectional descriptive design was used. The research was carried out in the diabetes polyclinic of a university hospital between June 2016 and January 2018. The study sample consisted of 91 patients. Data were collected with the scale of Montreal Cognitive Assessment (MoCA). The average score of the patients in the MoCA Scale was found to be 19.61 ± 1.70 (min: 15, max: 26). Diabetes is a risk factor for cognitive dysfunction for individuals above 65 years of age. Health professionals regularly monitor the cognitive functions of diabetic patients and use the MoCA scale in these follow-up and plan training and counseling initiatives according to their needs.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"171-175"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36526430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caregiver Burden and Desire for Institutional Placement-The Roles of Positive Aspects of Caregiving and Religious Coping. 照护者的负担和对机构安置的渴望--照护的积极方面和宗教应对的作用。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2019-01-30 DOI: 10.1177/1533317519826217
Noelle L Fields, Ling Xu, Vivian J Miller
{"title":"Caregiver Burden and Desire for Institutional Placement-The Roles of Positive Aspects of Caregiving and Religious Coping.","authors":"Noelle L Fields, Ling Xu, Vivian J Miller","doi":"10.1177/1533317519826217","DOIUrl":"10.1177/1533317519826217","url":null,"abstract":"<p><p>Based on stress coping theory, this study investigated whether and how positive aspects of caregiving (PAC) and religiosity buffered the association between caregiving burden and desire to institutionalize (DTI). Secondary data (N = 637) were drawn from the baseline assessment of the Resources for Enhancing Alzheimer's Caregiver Health II project. Descriptive analysis, bivariate correlation, and multiple linear regressions were conducted. The results indicated that higher levels of caregiver burden, daily care bother, and Revised Memory and Behavioral Problem Checklist bother were all significantly associated with higher level of DTI. Both PAC and religious coping were negatively associated with DTI; however, only PAC was significant. Only the interaction between daily care bother and religious coping was significant, which indicated that the harmful effect of daily care bother on DTI was significantly buffered among those who have religiosity. Study findings have important implications for policy makers and for providers who serve dementia family caregivers.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"199-207"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Nursing Home Residents With Dementia Receive Pain Interventions? 患有痴呆症的疗养院居民是否会接受疼痛干预?
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 DOI: 10.1177/1533317519840506
Taeko Nakashima, Yuchi Young, Wan-Hsiang Hsu
{"title":"Do Nursing Home Residents With Dementia Receive Pain Interventions?","authors":"Taeko Nakashima, Yuchi Young, Wan-Hsiang Hsu","doi":"10.1177/1533317519840506","DOIUrl":"10.1177/1533317519840506","url":null,"abstract":"<p><p>This study compares pain interventions received by nursing home residents with and without dementia. Secondary data analyses of cross-sectional data from 50,673 nursing home residents in New York State were collected by the Minimum Data Set 3.0. Frequency distributions and bivariate analyses with χ<sup>2</sup> tests were used to organize and summarize the data. Logistic regression analyses were performed to quantify the relationship between dementia and pain interventions. Our results show that residents with dementia had significantly fewer pain assessments and less reported pain presence than their counterparts. After adjusting for covariates, the results indicate that residents with dementia were significantly less likely to receive pro re nata and nonmedication pain intervention. However, there were no significant differences in scheduled pain medication between the 2 groups. To address the gap, we need more research to design a pain assessment tool that can differentiate severity of pain so that appropriate interventions can be applied.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"193-198"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37142309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Continuity/Discontinuity-A Framework for Investigating the Role of Relationships in the Experience of Living With Dementia. 关系的连续性/不连续性--研究关系在痴呆症患者生活体验中的作用的框架》(Relationship Continuity/Discontinuity-A Framework for Investigating Role of Relationships in the Experience of Living With Dementia)。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-11-19 DOI: 10.1177/1533317518813557
Gerard A Riley
{"title":"Relationship Continuity/Discontinuity-A Framework for Investigating the Role of Relationships in the Experience of Living With Dementia.","authors":"Gerard A Riley","doi":"10.1177/1533317518813557","DOIUrl":"10.1177/1533317518813557","url":null,"abstract":"<p><p>A recent paper (Riley, Evans and Oyebode, 2018) reported that a sense of discontinuity in carers' experience of their spousal relationship with a person with dementia is associated with a greater sense of burden and fewer rewards from the caregiving role. This commentary sets the paper in context by providing a brief overview of research relating to relationship continuity/discontinuity. Factors that may explain why some carers experience continuity but others discontinuity are reviewed. So, too, is the potential impact of continuity/discontinuity on how the carer copes with the challenges of dementia. Possible future research is discussed.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"145-147"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36696601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Single-Blind Randomized Controlled Trial With Language Training in People With Mild Cognitive Impairment. 在轻度认知障碍患者中开展语言训练的单盲随机对照对比试验。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-12-05 DOI: 10.1177/1533317518813554
Eleni Poptsi, Ioulietta Lazarou, Nefeli Markou, Maria Vassiloglou, Evdokia Nikolaidou, Alexandra Diamantidou, Vassiliki Siatra, Elina Karathanassi, Anastasios Karakostas, Fotini Kounti Zafeiropoulou, Thrasyvoulos Tsiatsos, Magda Tsolaki
{"title":"A Comparative Single-Blind Randomized Controlled Trial With Language Training in People With Mild Cognitive Impairment.","authors":"Eleni Poptsi, Ioulietta Lazarou, Nefeli Markou, Maria Vassiloglou, Evdokia Nikolaidou, Alexandra Diamantidou, Vassiliki Siatra, Elina Karathanassi, Anastasios Karakostas, Fotini Kounti Zafeiropoulou, Thrasyvoulos Tsiatsos, Magda Tsolaki","doi":"10.1177/1533317518813554","DOIUrl":"10.1177/1533317518813554","url":null,"abstract":"<p><strong>Background: </strong>Although cognitive training is effective for people with mild cognitive impairment (MCI), it is not clear which format is more effective.</p><p><strong>Objective: </strong>To compare the effectiveness of the same language programs when carried out via computer, paper/pencil and orally in people with MCI.</p><p><strong>Methods: </strong>Seventy-one participants with MCI were randomly classified in 3 experimental and 2 control groups. The experimental groups attended 48 sessions of language training for 6 months. The control groups attended either unstructured sessions or they were on waiting list.</p><p><strong>Results: </strong>Mixed measures analysis of variance, at the follow-up, showed a significant cognitive abilities improvement among the experimental versus control groups. At the end of the language training, the 3 groups presented improvement in cognitive abilities and daily function, while the control groups remained at the same performance level.</p><p><strong>Conclusion: </strong>All 3 cognitive language training methods were equally significantly effective.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"176-187"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36754577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of Dementia Related to the Use of Alcohol in the French Nationwide Discharge Summary Database Between 2007 and 2017. 2007 年至 2017 年间法国全国出院摘要数据库中与饮酒有关的痴呆症演变情况。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-12-30 DOI: 10.1177/1533317518822043
Michaël Rochoy, Sophie Gautier, Johana Béné, Régis Bordet, Emmanuel Chazard
{"title":"Evolution of Dementia Related to the Use of Alcohol in the French Nationwide Discharge Summary Database Between 2007 and 2017.","authors":"Michaël Rochoy, Sophie Gautier, Johana Béné, Régis Bordet, Emmanuel Chazard","doi":"10.1177/1533317518822043","DOIUrl":"10.1177/1533317518822043","url":null,"abstract":"<p><strong>Background: </strong>The French nationwide exhaustive hospital discharge database (PMSI) is used for activity-based payment of hospital services. We hypothesized that the release of articles about alcohol and dementia could influence the identification of these diagnoses in PMSI.</p><p><strong>Methods: </strong>We analyzed temporal evolution of coding for dementia and other persistent or late-onset cognitive impairment (OPLOCI) due to alcohol and other psychoactive substances in the PMSI database from 2007 to 2017 (285 748 938 inpatient stays). These codings use the International Classification of Diseases, 10th revision (ICD-10).</p><p><strong>Results: </strong>The number of inpatient stays with dementia and OPLOCI due to alcohol increased from 34 to 1704 from 2007 to 2017. While the number of diagnosed dementias remained stable at around 400 from 2013, the number of OPLOCIs increased 10-fold from 2013 to 2017. This increase was not found with dementia or OPLOCI due to other psychoactive substances than alcohol.</p><p><strong>Conclusion: </strong>Notoriety of a diagnosis in the literature seems to have an impact on the coding.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"188-192"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36865873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Video Feedback at Home in Dementia Care: A Feasibility Study. 在老年痴呆症护理中使用视频反馈:可行性研究。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-10-23 DOI: 10.1177/1533317518808021
Debby L Gerritsen, Raymond T C M Koopmans, Veerle Walravens, Deliane van Vliet
{"title":"Using Video Feedback at Home in Dementia Care: A Feasibility Study.","authors":"Debby L Gerritsen,&nbsp;Raymond T C M Koopmans,&nbsp;Veerle Walravens,&nbsp;Deliane van Vliet","doi":"10.1177/1533317518808021","DOIUrl":"https://doi.org/10.1177/1533317518808021","url":null,"abstract":"<p><p>Video feedback at home (VFH) aims to improve the well-being of informal caregivers and persons with dementia by training the caregiver to communicate successfully. This feasibility study had 2 aims: (1) to investigate possible effects regarding VFH, caregiver self-efficacy and the burden experienced, and the frequency of challenging behavior in persons with dementia, and (2) to perform a process evaluation of barriers and facilitators regarding the use of VFH. The respondents were caregivers of home-dwelling persons with dementia participating in VHF (N = 10), a group of caregivers who declined participating in VFH (N = 18), stakeholders (N = 6), and field experts (N = 55). The assessments performed were Positive and Negative Affect Scales, Cohen-Mansfield Agitation Inventory, Sense of Competence Scale, semistructured interviews, and questionnaires. Results demonstrated that caregivers were satisfied with VFH and that various (sub)scores on questionnaires improved. Caregivers mentioned a reluctance toward being filmed and both caregivers and referrers were unfamiliar with VFH. Recommendations have been made for health-care professionals and researchers to overcome these barriers.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"153-162"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1533317518808021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36600273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Do Caregiver Characteristics Affect Caregiver Burden Differently in Different Countries? 不同国家的护理者特征对护理者负担的影响不同吗?
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-12-30 DOI: 10.1177/1533317518822047
Uwe Konerding, Tom Bowen, Paul Forte, Eleftheria Karampli, Tomi Malmström, Elpida Pavi, Paulus Torkki, Elmar Graessel
{"title":"Do Caregiver Characteristics Affect Caregiver Burden Differently in Different Countries?","authors":"Uwe Konerding, Tom Bowen, Paul Forte, Eleftheria Karampli, Tomi Malmström, Elpida Pavi, Paulus Torkki, Elmar Graessel","doi":"10.1177/1533317518822047","DOIUrl":"10.1177/1533317518822047","url":null,"abstract":"<p><p>The relationships between caregiver burden as measured with the Burden Scale for Family Caregivers-short form and 6 characteristics of caregivers caring for patients with dementia were investigated for caregivers from England (n = 36), Finland (n = 42), and Greece (n = 46) using survey data. In all 3 countries, caregiver burden increases with physical problems of the caregiver, emotional problems of the caregiver, and weekly hours of care. Hence, in all 3 countries, special support for informal care is required when these characteristics are at high levels. When the caregiver is a spouse or long-term partner of the person with dementia, lives in the same house as this person, or spends fewer than 20 h/wk for other duties than care, this is associated with less caregiver burden in England but with more caregiver burden in Greece. Accordingly, special support is required for Greek caregivers with these characteristics, but the opposite is true for English caregivers.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"148-152"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36821880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Benefits of the TimeSlips Creative Storytelling Program for Persons With Varying Degrees of Dementia Severity. 评估 TimeSlips 创意讲故事计划对不同程度痴呆症患者的益处。
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-05-01 Epub Date: 2018-10-07 DOI: 10.1177/1533317518802427
Alyssa A Vigliotti, Vernon M Chinchilli, Daniel R George
{"title":"Evaluating the Benefits of the TimeSlips Creative Storytelling Program for Persons With Varying Degrees of Dementia Severity.","authors":"Alyssa A Vigliotti, Vernon M Chinchilli, Daniel R George","doi":"10.1177/1533317518802427","DOIUrl":"10.1177/1533317518802427","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the benefits of TimeSlips, a group creative storytelling intervention used in residential care settings, on quality of life (QOL), interactions with caregivers, and Mini-Mental State Examination (MMSE) scores for persons with varying degrees of dementia severity.</p><p><strong>Design: </strong>A mixed-methods approach was used weekly over a 6-month period to measure QOL and resident-caregiver relationships.</p><p><strong>Setting: </strong>A dementia care unit in Pennsylvania.</p><p><strong>Participants: </strong>Twenty-two residents with mild-to-severe dementia.</p><p><strong>Measurements: </strong>Dementia severity and QOL were assessed using the MMSE and Greater Cincinnati Chapter Well-Being Observational Tool. Resident-caregiver interactions were analyzed using a modified version of the Quality of Interactions Schedule. Semistructured interviews were conducted upon the study's conclusion.</p><p><strong>Results: </strong>Quantitatively, participants initially classified with mild-moderate dementia were significantly more likely to experience positive benefits compared to those initially classified with severe dementia. There were no significant changes in dementia severity over time. There was also no change in QOL or resident-caregiver relationships for those with mild-moderate dementia over time, although there was a decrease in certain measures of QOL and resident-caregiver relationships for those with severe dementia. Qualitative analysis identified consistent benefits for residents with both mild-moderate and severe dementia over time.</p><p><strong>Conclusions: </strong>Mixed-methods analyses helped identify benefits of TimeSlips for persons at all levels of dementia severity, but particularly for those with milder dementia. Such an observation helps demonstrate how arts-based programs like TimeSlips can uniquely benefit people with advanced memory impairments and thereby support QOL.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 3","pages":"163-170"},"PeriodicalIF":3.4,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36553734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying Brain Connectivity Using Network-Based Statistics in Amnestic Mild Cognitive Impairment Stratified by β-Amyloid Positivity. 利用基于网络的统计数据识别按β-淀粉样蛋白阳性率分层的失忆性轻度认知障碍患者的大脑连通性
IF 3.4 4区 医学
American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-03-01 Epub Date: 2018-11-29 DOI: 10.1177/1533317518813556
Ji Eun Kim, Sung-Woo Kim, Minsuk Choi, Joon-Kyung Seong, Jae-Hong Lee
{"title":"Identifying Brain Connectivity Using Network-Based Statistics in Amnestic Mild Cognitive Impairment Stratified by β-Amyloid Positivity.","authors":"Ji Eun Kim, Sung-Woo Kim, Minsuk Choi, Joon-Kyung Seong, Jae-Hong Lee","doi":"10.1177/1533317518813556","DOIUrl":"10.1177/1533317518813556","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to identify white matter structural networks of amnestic mild cognitive impairment (aMCI) dichotomized by β amyloid (Aβ) status and compare them using network-based statistics (NBS).</p><p><strong>Methods: </strong>Patients underwent whole-brain diffusion-weighted magnetic resonance imaging, detailed neuropsychological test and [<sup>18</sup>F]-Florbetaben amyloid positron emission tomography. We performed the NBS analysis to compare the whole-brain white matter structural networks extracted from diffusion tensor images.</p><p><strong>Results: </strong>One hundred sixteen participants (Aβ- cognitively normal [CN], n = 35; Aβ- aMCI, n = 42; Aβ+ aMCI, n = 39) were included. There was no subnetwork showing significant difference between Aβ+ aMCI and Aβ- aMCI. However, by comparing each aMCI group with control group, we found that supplementary motor areas were common hub regions. Intriguingly, Aβ+ aMCI showed reduced connectivity mainly in the medial frontal regions, while Aβ- aMCI showed somewhat uniform disruption when compared to CN.</p><p><strong>Conclusion: </strong>Structural network analysis using network-based approach in aMCI may shed light on further understanding of white matter disruption in the prodromal stage of Alzheimer's disease.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 2","pages":"104-111"},"PeriodicalIF":3.4,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36720868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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