American Journal of Alzheimers Disease and Other Dementias最新文献

The Psychological Symptoms and Their Relationship to the Quality of Life Among Dementia Patients Caregivers 痴呆症患者护理人员的心理症状及其与生活质量的关系

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2024-04-15 DOI: 10.1177/15333175241248056

Mamduh Baniah Lafee Alzaben, Baha’ Suhail Mousa Shawaqfeh

引用次数: 0

Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer’s Disease and Reflect Central Neuroinflammation 髓系细胞上表达的外周触发受体 2 mRNA 的不同剪接异构体表达与阿尔茨海默氏症所致轻度痴呆的认知能力下降有关，并反映了中枢神经炎症

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2024-04-09 DOI: 10.1177/15333175241243183

Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh

{"title":"Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer’s Disease and Reflect Central Neuroinflammation","authors":"Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh","doi":"10.1177/15333175241243183","DOIUrl":"https://doi.org/10.1177/15333175241243183","url":null,"abstract":"Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline in patients with Alzheimer’s disease (AD). There is conflicting evidence regarding the association of peripheral TREM2 mRNA expression/soluble TREM2 (the extracellular domain of TREM2) with cognitive function/neuroinflammation in patients with AD. Herein, we studied the TREM2 and TREM2alt mRNA expression and their association with the cognitive performance in subjects with mild dementia due to AD and healthy controls. In a subgroup of patients with AD, magnetic resonance spectroscopy was used to measure the myo-inositol level in the posterior cingulate cortex, a surrogate marker for neuroinflammation. The results showed that increased TREM2 and TREM2alt mRNA expression is associated with AD pathogenesis at the mild dementia stage, thereby serving as a potential biomarker for early symptomatic stage of AD. TREM2 may exert protective effects on both cognition and central neuroinflammation.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140591391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White Light Stimulation at Gamma Frequency to Modify the Aβ42 and tau Proteins in SH-SY5Y Cells 伽马频率的白光刺激改变 SH-SY5Y 细胞中的 Aβ42 和 tau 蛋白质

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2024-03-04 DOI: 10.1177/15333175241236251

Yang-Pei Chang, Ching-Fang Chien, Ling-Chun Huang, Chih-Pin Chuu, Hsi-Wen Chang, Tzyh-Chyuan Hour, Yuan-Han Yang

引用次数: 0

Tailored Music Listening in Persons With Dementia: A Feasibility Randomized Clinical Trial. 痴呆症患者量身定制的音乐听力：一项可行性随机临床试验。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231186728

Darina V Petrovsky, Joke Bradt, Miranda V McPhillips, Justine S Sefcik, Laura N Gitlin, Nancy A Hodgson

{"title":"Tailored Music Listening in Persons With Dementia: A Feasibility Randomized Clinical Trial.","authors":"Darina V Petrovsky, Joke Bradt, Miranda V McPhillips, Justine S Sefcik, Laura N Gitlin, Nancy A Hodgson","doi":"10.1177/15333175231186728","DOIUrl":"10.1177/15333175231186728","url":null,"abstract":"Introduction: This study examined the feasibility, acceptability, and preliminary efficacy of tailored music listening intervention on sleep disturbances in older adults with dementia and their caregivers. Methods: We randomly assigned 33 older adults with dementia (mean age 71.7 [SD: 7.1], 72.7% female, 81.8% African American/Black) and their caregivers (mean age 58.4 [SD: 16.7], 72.7% female, 84.8% African American/Black) to a wait-list control or intervention group (NCT04157244). Results: The music intervention was feasible as evidenced by high study measure completion and retention rates (>90%). Recruitment was stopped prematurely due to the COVID-19 pandemic. We found mixed acceptability results from the survey and qualitative interviews with the participants. Both groups improved on objective sleep outcomes of sleep latency and wake sleep after onset. We found a small effect size for sleep duration post-intervention. Discussion: The findings provide preliminary evidence for the feasibility of a tailored music intervention and identified ways to improve its acceptability.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489003/pdf/nihms-1923968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diastolic Blood Pressure and Cognitive Functioning: Differences by Systolic Blood Pressure Among US Adults. 舒张压与认知功能：美国成年人收缩压的差异。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231172283

A Mathew, R A Mesa, L Nahodyl, J Tremblay, T Rundek, A Zeki Al Hazzouri, T Elfassy

{"title":"Diastolic Blood Pressure and Cognitive Functioning: Differences by Systolic Blood Pressure Among US Adults.","authors":"A Mathew, R A Mesa, L Nahodyl, J Tremblay, T Rundek, A Zeki Al Hazzouri, T Elfassy","doi":"10.1177/15333175231172283","DOIUrl":"10.1177/15333175231172283","url":null,"abstract":"Background: The role of diastolic blood pressure (DBP) with cognitive functioning is under-explored in relation to levels of systolic blood pressure (SBP).Methods: We studied 5466 participants from the National Health and Nutrition Examination Survey. Blood pressure was measured 3 times manually with a standardized sphygmomanometer and averaged. Cognitive functioning was measured using the digit symbol substitution test (DSST).Results: Participants were 60 years or older, 55% female, and 81% non-Hispanic White. Most participants had a DBP between 70 to <80 mmHg (33.7%), between 60 to <70 mmHg (29.3%), or <60 mmHg (18.8%). From multivariable linear regression analyses, each 5 mmHg increment of DBP was associated with significantly higher DSST scores among individuals with SBP <120 only (ß: 0.56, 95% CI: 0.09, 1.03).Conclusions: Among older US adults, at non-elevated levels of SBP, higher DBP is associated with better cognitive performance.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398835/pdf/nihms-1912191.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality. 晚年肥胖是预防痴呆和痴呆相关死亡率的一个保护因素。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175221111658

Ginny Natale, Yun Zhang, Douglas William Hanes, Sean Ap Clouston

{"title":"Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality.","authors":"Ginny Natale, Yun Zhang, Douglas William Hanes, Sean Ap Clouston","doi":"10.1177/15333175221111658","DOIUrl":"10.1177/15333175221111658","url":null,"abstract":"Objective: We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia.Methods: We analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight. Multi-state survival models (MSMs) examined misclassification probability, time-to-event ratios, and cognitive decline.Results: Participants (n = 6078) were 77 years old, 62% had overweight and/or obese BMI. After adjusting for the effects of cardiometabolic factors, age, sex, and race, obesity was protective against developing dementia (aHR=.44; 95%CI [.29-.67]) and dementia-related mortality (aHR=.63; 95%CI [.42-.95]).Discussion: We found a negative relationship between obesity and dementia and dementia-related mortality, a finding that has been underreported in the literature. The continuing obesity epidemic might complicate the diagnosis and treatment of dementia.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer's Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age. 阿尔茨海默病三转基因小鼠 3、6 和 9 个月大时空间记忆和肠道微生物群组成的改变

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231174193

Zhang Wei, Daidi Li, Jingshan Shi

引用次数: 0

The Use of Verbal and Nonverbal Memory Tests for Alzheimer's Disease Screening in Taiwan Chinese. 言语和非言语记忆测试在台湾地区阿尔茨海默病筛查中的应用。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231201036

Kuan-Ying Li, Ching-Fang Chien, Tang-Wei Huang, Yuan-Han Yang

{"title":"The Use of Verbal and Nonverbal Memory Tests for Alzheimer's Disease Screening in Taiwan Chinese.","authors":"Kuan-Ying Li, Ching-Fang Chien, Tang-Wei Huang, Yuan-Han Yang","doi":"10.1177/15333175231201036","DOIUrl":"10.1177/15333175231201036","url":null,"abstract":"Patients with Alzheimer's disease typically have initial deficits in memory. Memory testing can be categorized as verbal or nonverbal by the modality of the stimuli used. We compared the discriminative validity of selected verbal and nonverbal memory tests between non-dementia and Alzheimer's disease in Taiwan. Ninety-eight patients with mild Alzheimer's disease and 269 non-dementia individuals underwent story recall test (immediate and delayed recall), and constructional praxis test (copy and delayed recall). The receiver-operating characteristic curve and area under the curve were evaluated to compare between tests. Patients with Alzheimer's disease performed poorly across all memory tests, and the receiver-operating characteristic curve analysis indicated that story recall immediate and relayed recall, and constructional praxis delayed recall had good classification accuracy with area under the curve of .90, .87 and .87 respectively. These results provide support that both verbal and nonverbal memory tests are reliable measure for screening patients with Alzheimer's disease.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life Ratings and Proxy Bias in Primary Progressive Aphasia: Two Sides to the Story? 原发性进行性失语症的生活质量评分和代理偏差：故事的两面性？

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231177668

Leanne Ruggero, Karen Croot, Lyndsey Nickels

引用次数: 0

Changes in Selected Cognitive and Motor Skills as Well as the Quality of Life After a 24-Week Multidimensional Music-Based Exercise Program in People With Dementia. 痴呆症患者在为期24周的基于多维音乐的锻炼项目后，所选认知和运动技能以及生活质量的变化。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231191022

Alexander Prinz, Anneke Schumacher, Kerstin Witte

{"title":"Changes in Selected Cognitive and Motor Skills as Well as the Quality of Life After a 24-Week Multidimensional Music-Based Exercise Program in People With Dementia.","authors":"Alexander Prinz, Anneke Schumacher, Kerstin Witte","doi":"10.1177/15333175231191022","DOIUrl":"10.1177/15333175231191022","url":null,"abstract":"The loss of independence is one of the greatest consequences of dementia. Multidimensional music-based exercise programs could counteract. The present study investigates the effects of such a program on people with dementia and bases on a 24-week intervention with three measurement time points. Sixty-nine people with dementia were randomly assigned to the intervention (n = 43) and control group (n = 26). The following outcome parameters were measured: leg strength, gait, grip strength, balance, reaction time, selected cognitive abilities, and quality of life. A mixed ANOVA with repeated measurement showed significant interaction effects between group and time. After 24-weeks in contrast to the control group the intervention group significantly improved in leg strength (P = .001), balance (P = .001), gait (P = .001), grip strength (right P = .002, left P = .011), reaction time (P = .003), global cognition (P = .039), verbal fluency (P = .002), attention (P = .013) and quality of life (P = .011). In conclusion, the program enhanced selected cognitive and motor skills and quality of life.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0