Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer’s Disease and Reflect Central Neuroinflammation

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2024-04-09 DOI:10.1177/15333175241243183

Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh

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Abstract

Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline in patients with Alzheimer’s disease (AD). There is conflicting evidence regarding the association of peripheral TREM2 mRNA expression/soluble TREM2 (the extracellular domain of TREM2) with cognitive function/neuroinflammation in patients with AD. Herein, we studied the TREM2 and TREM2alt mRNA expression and their association with the cognitive performance in subjects with mild dementia due to AD and healthy controls. In a subgroup of patients with AD, magnetic resonance spectroscopy was used to measure the myo-inositol level in the posterior cingulate cortex, a surrogate marker for neuroinflammation. The results showed that increased TREM2 and TREM2alt mRNA expression is associated with AD pathogenesis at the mild dementia stage, thereby serving as a potential biomarker for early symptomatic stage of AD. TREM2 may exert protective effects on both cognition and central neuroinflammation.

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髓系细胞上表达的外周触发受体 2 mRNA 的不同剪接异构体表达与阿尔茨海默氏症所致轻度痴呆的认知能力下降有关，并反映了中枢神经炎症

髓系细胞上表达的触发受体2（TREM2）在活化的小胶质细胞中上调，可能与阿尔茨海默病（AD）患者认知能力下降有关。关于外周TREM2 mRNA表达/可溶性TREM2（TREM2的胞外结构域）与阿尔茨海默病患者认知功能/神经炎症的关系，目前还存在相互矛盾的证据。在此，我们研究了AD轻度痴呆症患者和健康对照组的TREM2和TREM2alt mRNA表达及其与认知能力的关系。在AD患者中，我们使用磁共振波谱测量了后扣带回皮质中肌醇的水平，这是神经炎症的替代标志物。结果表明，TREM2和TREM2alt mRNA表达的增加与轻度痴呆阶段的AD发病机制有关，因此可作为AD早期症状阶段的潜在生物标志物。TREM2可能对认知和中枢神经炎症都有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).