American Journal of Alzheimers Disease and Other Dementias最新文献_第10页

Cognitive Stimulating Play Intervention for Dementia: A Feasibility Randomized Controlled Trial. 针对痴呆症的认知刺激游戏干预：可行性随机对照试验。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-02-01 Epub Date: 2018-10-28 DOI: 10.1177/1533317518808036

Daphne Sze Ki Cheung, Bingyu Li, Daniel Wing Leung Lai, Angela Yee Man Leung, Clare Tze Kiu Yu, Ka Tat Tsang

{"title":"Cognitive Stimulating Play Intervention for Dementia: A Feasibility Randomized Controlled Trial.","authors":"Daphne Sze Ki Cheung, Bingyu Li, Daniel Wing Leung Lai, Angela Yee Man Leung, Clare Tze Kiu Yu, Ka Tat Tsang","doi":"10.1177/1533317518808036","DOIUrl":"10.1177/1533317518808036","url":null,"abstract":"This study investigates the feasibility and the preliminary efficacy of a Cognitive Stimulating Play Intervention on cognitive functions. Thirty older people with early to moderate dementia were recruited from 2 day-care centers, which were randomized into intervention and control groups. The recruitment, attendance, completion rates, and the interview with staff showed that the intervention was feasible. Analysis of covariance results showed that there was a significant difference between groups on memory storage and retrieval functions. The mean memory storage and retrieval functions were 5.92 (95% confidence interval [CI]: 1.83-9.91; P = .006) and 4.12 (95% CI: 0.75-7.50; P = .018) points higher than that for the control group, respectively, which contributed moderate to large effects (partial η2 = 0.189-0.248). There was no significant difference between groups in global cognition measured using the Montreal Cognitive Assessment and verbal fluency. Practical issues that emerged during implementation were discussed.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 1","pages":"63-71"},"PeriodicalIF":3.4,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36672032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Hand Exercise on Eating Action in Patients With Alzheimer's Disease. 手部运动对阿尔茨海默病患者进食动作的影响

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-02-01 Epub Date: 2018-10-09 DOI: 10.1177/1533317518803722

Li-Li Chen, Hong Li, Xiao-Huan Chen, Shuang Jin, Qiu-Hua Chen, Mei-Rong Chen, Na Li

引用次数: 0

Reduced Lexical Access to Verbs in Individuals With Subjective Cognitive Decline. 主观认知能力下降的人对动词的词性获取能力降低。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-02-01 Epub Date: 2018-07-24 DOI: 10.1177/1533317518790541

Joël Macoir, Anne Lafay, Carol Hudon

引用次数: 0

Empowering Patients with Alzheimer's Disease To Avoid Unwanted Medical Care: A Look At The Dementia Care Triad. 增强阿尔茨海默病患者的能力，避免不必要的医疗护理：痴呆症护理的三要素。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-13 DOI: 10.1177/1533317518817614

Wayne Shelton, Evelyn Tenenbaum, Kevin Costello, David Hoffman

引用次数: 0

Neurochemical Aspects of Alzheimer's Disease and Movement Disturbances: A Theory of β-Amyloid and τ-Protein. 阿尔茨海默病和运动障碍的神经化学方面：β-淀粉样蛋白和τ-蛋白理论。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-07-25 DOI: 10.1177/1533317518790631

Auda Fares, Dieter Borrmann

{"title":"Neurochemical Aspects of Alzheimer's Disease and Movement Disturbances: A Theory of β-Amyloid and τ-Protein.","authors":"Auda Fares, Dieter Borrmann","doi":"10.1177/1533317518790631","DOIUrl":"10.1177/1533317518790631","url":null,"abstract":"The pathologic and molecular substrate of people diagnosed with cognitive deficits and movement disturbance may not occur exclusively in the context of a brain region, but it may be expressed in another part of body such as muscle. A large body of research has demonstrated that slow motor performance is associated with cognitive impairment in elderly people. The interdependence between motor dysfunction and cognition decline is still not fully understood. Although several factors have been suggested to give a plausible explanation, β-amyloid (Aβ) and τ-protein aggregation is a common feature of a number of neurodegenerative disorders which are characterized by both motor and cognitive impairment, and it is assumed that the aggregation process plays a central role in the pathogenesis of cognitive impairment and motor dysfunction in Alzheimer's disease. The purpose of the present review is to provide an overview of the available evidence that can help to better elucidate the pathophysiological mechanisms underlying the relationship between cognitive and movement disturbances by focusing on Aβ and τ-protein.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"33 8","pages":"535-540"},"PeriodicalIF":3.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36344443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link? 女性怀孕生活史与阿尔茨海默病风险:免疫调节能解释两者之间的联系吗?

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-07-30 DOI: 10.1177/1533317518786447

Molly Fox, Carlo Berzuini, Leslie A Knapp, Laura M Glynn

{"title":"Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link?","authors":"Molly Fox, Carlo Berzuini, Leslie A Knapp, Laura M Glynn","doi":"10.1177/1533317518786447","DOIUrl":"https://doi.org/10.1177/1533317518786447","url":null,"abstract":"Background: Pregnancy is associated with improvement in immunoregulation that persists into the geriatric phase. Impaired immunoregulation is implicated in Alzheimer's disease (AD) pathogenesis. Hence, we investigate the relationship between pregnancy and AD.Methods: Cross-sectional cohort of British women (N = 95). Cox proportional hazards modeling assessed the putative effects of cumulative months pregnant on AD risk and the mutually adjusted effects of counts of first and third trimesters on AD risk.Results: Cumulative number of months pregnant, was associated with lower AD risk (β = -1.90, exp(β) = 0.15, P = .02). Cumulative number of first trimesters was associated with lower AD risk after adjusting for third trimesters (β = -3.83, exp(β) = 0.02, P < .01), while the latter predictor had no significant effect after adjusting for the former.Conclusions: Our observation that first trimesters (but not third trimesters) conferred protection against AD is more consistent with immunologic effects, which are driven by early gestation, than estrogenic exposures, which are greatest in late gestation. Results may justify future studies with immune biomarkers.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"33 8","pages":"516-526"},"PeriodicalIF":3.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1533317518786447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36356860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Comparison of Blood Lead Levels in Patients With Alzheimer's Disease and Healthy People. 阿尔茨海默病患者与健康人血液中铅含量的比较。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-08-22 DOI: 10.1177/1533317518794032

Babak Fathabadi, Mohammad Dehghanifiroozabadi, Jan Aaseth, Gholamreza Sharifzadeh, Samaneh Nakhaee, Ali Rajabpour-Sanati, Alireza Amirabadizadeh, Omid Mehrpour

{"title":"Comparison of Blood Lead Levels in Patients With Alzheimer's Disease and Healthy People.","authors":"Babak Fathabadi, Mohammad Dehghanifiroozabadi, Jan Aaseth, Gholamreza Sharifzadeh, Samaneh Nakhaee, Ali Rajabpour-Sanati, Alireza Amirabadizadeh, Omid Mehrpour","doi":"10.1177/1533317518794032","DOIUrl":"10.1177/1533317518794032","url":null,"abstract":"Background: It is argued that breakdown of β-amyloid in the brain causes deposition of senescent plaques and therefore Alzheimer's disease (AD). One of the influential factors for increasing level of this protein is exposure to lead. Our aim was to compare blood lead levels (BLLs) between patients with AD and healthy controls.Methods: This case-control study was performed on all patients with cognitive impairment who were referred to the Neurological Clinic of Birjand in 2016 to 2017. Patients were referred to the laboratory for measurement of their serum levels of lead. The controls and patients were matched by age and sex.Results: In the AD case group, the average BLL was 22.22 ± 28.57 μg/dL. Mann-Whitney U test showed that BLLs were significantly higher in the patients than in the controls. The unadjusted odds ratio for BLL among the patients was 1.05 (95% confidence interval: 1.01-1.09; P = .01) compared to the controls.Conclusion: In the present study, BLL was associated with AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"33 8","pages":"541-547"},"PeriodicalIF":3.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36416615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Composition, Dietary, and Gustatory Function Assessment in People With Alzheimer's Disease. 对阿尔茨海默病患者的身体成分、饮食和味觉功能进行评估。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-06-19 DOI: 10.1177/1533317518782173

Ismael San Mauro Martín, Víctor Paredes Barato, Sara López Oliva, Marta Rodríguez, Luis Collado Yurrita, Maria José Ciudad Cabañas, Sara Sanz Rojo, Licia de la Calle, Elena Ávila Díaz, Yaiza Quevedo Santos, Paloma Elortegui Pascual, Marta Villanueva Nieto, Elena Garicano Vilar

{"title":"Body Composition, Dietary, and Gustatory Function Assessment in People With Alzheimer's Disease.","authors":"Ismael San Mauro Martín, Víctor Paredes Barato, Sara López Oliva, Marta Rodríguez, Luis Collado Yurrita, Maria José Ciudad Cabañas, Sara Sanz Rojo, Licia de la Calle, Elena Ávila Díaz, Yaiza Quevedo Santos, Paloma Elortegui Pascual, Marta Villanueva Nieto, Elena Garicano Vilar","doi":"10.1177/1533317518782173","DOIUrl":"10.1177/1533317518782173","url":null,"abstract":"Objectives: Observe the association of foods habits, body composition, lifestyle habits, and loss of gustatory function with Alzheimer's disease (AD).Methods: This comparative study enrolled 75 patients with AD (mean age 77.5 years) and 267 healthy volunteers (mean age 73 years). Weight, height, body mass index (BMI), body fat, visceral fat, muscle mass, and waist circumference were measured. Adherence to the Mediterranean diet was measured by the Mediterranean-Diet-Adherence Screener. Gustatory function was investigated using a threshold and triangle test.Results: Cases with AD presented lower BMI and weight and higher sleep hours, being statistically significant the difference between cases and controls ( P = .02; P = .001; P = .001, respectively). Patients with AD showed lower adherence to exercise and Mediterranean diet as shown by the Mediterranean Diet Adherence Screener-score (8.12 ± 2.5 vs 8.65 ± 2.4). The gustatory function was impaired in patients with AD when compared to controls.Conclusion: Patients with AD show worst outcomes in terms of anthropometric measurements, lifestyle habits (diet, exercise), and gustatory function than controls.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"33 8","pages":"508-515"},"PeriodicalIF":3.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36234812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-09-24 DOI: 10.1177/1533317518802434

Ahmet Turan Isik, Pinar Soysal

引用次数: 0

Prevalence and Incidence of Statin Use and 3-Year Adherence and Discontinuation Rates Among Older Adults With Dementia. 老年痴呆症患者使用他汀类药物的流行率和发生率以及 3 年的坚持率和停药率。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-07-10 DOI: 10.1177/1533317518787314

Richard Ofori-Asenso, Jenni Ilomaki, Mark Tacey, Andrea J Curtis, Ella Zomer, J Simon Bell, Sophia Zoungas, Danny Liew

{"title":"Prevalence and Incidence of Statin Use and 3-Year Adherence and Discontinuation Rates Among Older Adults With Dementia.","authors":"Richard Ofori-Asenso, Jenni Ilomaki, Mark Tacey, Andrea J Curtis, Ella Zomer, J Simon Bell, Sophia Zoungas, Danny Liew","doi":"10.1177/1533317518787314","DOIUrl":"10.1177/1533317518787314","url":null,"abstract":"Objective: To examine the patterns of statin use and determine the 3-year adherence and discontinuation rates among a cohort of Australians aged ≥65 years with dementia.Methods: The yearly prevalence and incidence of statin use were compared via Poisson regression modeling using 2007 as the reference year. People with dementia were identified according to dispensing of antidementia medications. A cohort of 589 new statin users was followed longitudinally. Adherence was estimated via the proportion of days covered (PDC). Discontinuation was defined as ≥90 days without statin coverage.Results: The annual prevalence of statin use among older Australians with dementia increased from 20.6% in 2007 to 31.7% in 2016 (aged-sex adjusted rate ratio: 1.51, 95% confidence interval: 1.35-1.69). Among the new users, the proportion adherent (PDC ≥ 0.80) decreased from 60.3% at 6 months to 31.0% at 3 years. During the 3-year follow-up, 58.7% discontinued their statin.Conclusions: Despite increased use of statins among older Australians with dementia, adherence is low and discontinuation is high, which may point to intentional cessation.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"33 8","pages":"527-534"},"PeriodicalIF":3.4,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36298647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0