Prevalence and Incidence of Statin Use and 3-Year Adherence and Discontinuation Rates Among Older Adults With Dementia.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2018-12-01 Epub Date: 2018-07-10 DOI:10.1177/1533317518787314

Richard Ofori-Asenso, Jenni Ilomaki, Mark Tacey, Andrea J Curtis, Ella Zomer, J Simon Bell, Sophia Zoungas, Danny Liew

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引用次数: 0

Abstract

Objective: To examine the patterns of statin use and determine the 3-year adherence and discontinuation rates among a cohort of Australians aged ≥65 years with dementia.

Methods: The yearly prevalence and incidence of statin use were compared via Poisson regression modeling using 2007 as the reference year. People with dementia were identified according to dispensing of antidementia medications. A cohort of 589 new statin users was followed longitudinally. Adherence was estimated via the proportion of days covered (PDC). Discontinuation was defined as ≥90 days without statin coverage.

Results: The annual prevalence of statin use among older Australians with dementia increased from 20.6% in 2007 to 31.7% in 2016 (aged-sex adjusted rate ratio: 1.51, 95% confidence interval: 1.35-1.69). Among the new users, the proportion adherent (PDC ≥ 0.80) decreased from 60.3% at 6 months to 31.0% at 3 years. During the 3-year follow-up, 58.7% discontinued their statin.

Conclusions: Despite increased use of statins among older Australians with dementia, adherence is low and discontinuation is high, which may point to intentional cessation.

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老年痴呆症患者使用他汀类药物的流行率和发生率以及 3 年的坚持率和停药率。

目的在年龄≥65 岁的澳大利亚痴呆症患者中，研究他汀类药物的使用模式，并确定3 年的坚持率和停药率：方法：以 2007 年为参照年，通过泊松回归模型对他汀类药物的年使用率和发病率进行比较。根据抗痴呆药物的配发情况确定痴呆症患者。对 589 名他汀类药物新使用者的队列进行了纵向跟踪。通过覆盖天数比例（PDC）估算用药依从性。停药定义为他汀类药物覆盖天数≥90天：在患有痴呆症的澳大利亚老年人中，他汀类药物的年使用率从2007年的20.6%增至2016年的31.7%（经年龄-性别调整的比率比：1.51，95%置信区间：1.35-1.69）。在新用户中，坚持使用的比例（PDC ≥ 0.80）从 6 个月时的 60.3% 降至 3 年时的 31.0%。在3年的随访中，58.7%的人停止使用他汀类药物：结论：尽管澳大利亚老年痴呆症患者中他汀类药物的使用率有所上升，但依从性较低，停药率较高，这可能与有意停药有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).