Identifying Brain Connectivity Using Network-Based Statistics in Amnestic Mild Cognitive Impairment Stratified by β-Amyloid Positivity.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-03-01 Epub Date: 2018-11-29 DOI:10.1177/1533317518813556

Ji Eun Kim, Sung-Woo Kim, Minsuk Choi, Joon-Kyung Seong, Jae-Hong Lee

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引用次数: 0

Abstract

Background: The aim of this study was to identify white matter structural networks of amnestic mild cognitive impairment (aMCI) dichotomized by β amyloid (Aβ) status and compare them using network-based statistics (NBS).

Methods: Patients underwent whole-brain diffusion-weighted magnetic resonance imaging, detailed neuropsychological test and [¹⁸F]-Florbetaben amyloid positron emission tomography. We performed the NBS analysis to compare the whole-brain white matter structural networks extracted from diffusion tensor images.

Results: One hundred sixteen participants (Aβ- cognitively normal [CN], n = 35; Aβ- aMCI, n = 42; Aβ+ aMCI, n = 39) were included. There was no subnetwork showing significant difference between Aβ+ aMCI and Aβ- aMCI. However, by comparing each aMCI group with control group, we found that supplementary motor areas were common hub regions. Intriguingly, Aβ+ aMCI showed reduced connectivity mainly in the medial frontal regions, while Aβ- aMCI showed somewhat uniform disruption when compared to CN.

Conclusion: Structural network analysis using network-based approach in aMCI may shed light on further understanding of white matter disruption in the prodromal stage of Alzheimer's disease.

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利用基于网络的统计数据识别按β-淀粉样蛋白阳性率分层的失忆性轻度认知障碍患者的大脑连通性

研究背景本研究旨在识别根据β淀粉样蛋白（Aβ）状态二分的失忆性轻度认知障碍（aMCI）白质结构网络，并使用基于网络的统计学（NBS）对其进行比较：患者接受全脑弥散加权磁共振成像、详细的神经心理学测试和[18F]-氟贝他滨淀粉样蛋白正电子发射断层扫描。我们进行了 NBS 分析，以比较从弥散张量图像中提取的全脑白质结构网络：结果：共纳入 116 名参与者（Aβ- 认知正常[CN]，n = 35；Aβ- aMCI，n = 42；Aβ+ aMCI，n = 39）。Aβ+ aMCI 和 Aβ- aMCI 之间没有明显的子网络差异。然而，通过比较每组 aMCI 和对照组，我们发现辅助运动区是共同的枢纽区域。耐人寻味的是，Aβ+ aMCI主要在内侧额叶区域表现出连接性降低，而Aβ- aMCI与CN相比则表现出某种程度的均匀破坏：结论：采用基于网络的方法对 aMCI 进行结构网络分析，有助于进一步了解阿尔茨海默病前驱期白质破坏的情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).