American Journal of Preventive Medicine最新文献

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Age and Stage Trends in Early-Onset Colorectal Cancer Incidence Before and After the USPSTF 2021 Update. USPSTF 2021更新前后早发性结直肠癌发病率的年龄和分期趋势
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-08-25 DOI: 10.1016/j.amepre.2026.108568
Todd Burus, Jason Semprini
{"title":"Age and Stage Trends in Early-Onset Colorectal Cancer Incidence Before and After the USPSTF 2021 Update.","authors":"Todd Burus, Jason Semprini","doi":"10.1016/j.amepre.2026.108568","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108568","url":null,"abstract":"<p><strong>Introduction: </strong>Early-onset colorectal cancer (CRC) incidence has increased in the US, raising concern about changing risk among adults aged 20-49 years. In 2021, the US Preventive Services Task Force lowered the recommended starting age for average-risk CRC screening from 50 to 45 years. This study examined whether CRC incidence trends were concentrated among adults newly eligible for screening.</p><p><strong>Methods: </strong>Analyzing the latest SEER data for malignant CRCs from 2004-2023, the study estimated annual percentage changes (APCs) using log-linear regression for adults aged 20-49 years overall and for age groups 20-44, 45-49, and 50-54 years, further stratified by early-stage and late-stage diagnosis. Joint-Point analyses were performed as a sensitivity check.</p><p><strong>Results: </strong>In 2023, there were 10,395 early-onset CRC diagnoses, corresponding to an incidence rate of 18.1 per 100,000. Overall early-onset CRC incidence increased by 1.95% per year in 2004-2019 and 8.41% per year in 2021-2023. The largest recent increase occurred among adults aged 45-49 years, whose all-stage APC rose from 1.31% in 2004-2019 to 14.38% in 2021-2023. Among adults aged 45-49 years, early-stage CRC increased by 32.14% per year in 2021-2023, compared with 0.12% per year in 2004-2019; late-stage CRC increased by 3.29% per year in 2021-2023. Trends among adults aged 20-44 and 50-54 years were comparatively stable, but rising.</p><p><strong>Conclusions: </strong>Recent acceleration in early-onset CRC incidence was concentrated among adults aged 45-49 years, especially early-stage diagnoses, suggesting increased detection after expanded screening eligibility.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108568"},"PeriodicalIF":4.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Financial Burdens and Later Risks of Adult Psychological Distress (2014-2023). 成人心理困扰的医疗经济负担与后期风险(2014-2023)
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-08-24 DOI: 10.1016/j.amepre.2026.108555
Michael Caniglia, Laura J Chavez
{"title":"Medical Financial Burdens and Later Risks of Adult Psychological Distress (2014-2023).","authors":"Michael Caniglia, Laura J Chavez","doi":"10.1016/j.amepre.2026.108555","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108555","url":null,"abstract":"<p><strong>Introduction: </strong>Research suggests that medical debt and difficulty paying medical bills are associated with worse mental health. However, limited research examines the longitudinal association between medical spending as a proportion of income and later mental health.</p><p><strong>Methods: </strong>Using a series of two-year panels from the US Medical Expenditure Panel Survey-Household Components (2014-2023) (N=60,391 adults), this study employed longitudinal logistic regression models to examine the relationship between out-of-pocket and premium burdens in Year 1 and mental health outcomes in Year 2. Symptoms of severe psychological distress and probable major depression were measured using the Kessler-6 Severe Psychological Distress Scale and the Patient Health Questionnaire-2, respectively.</p><p><strong>Results: </strong>Among the study population, 63% of adults identified as non-Hispanic White, 16% as Hispanic, 12% as non-Hispanic Black, 6% as non-Hispanic Asian and Pacific Islander, 2% as non-Hispanic Multiracial and 1% as non-Hispanic American Indian or Alaska Native. The sample was 52% female. After controlling for covariates, adults with out-of-pocket burdens in Year 1 faced increased odds of both severe psychological distress [OR 1.405; 95% CI=1.182, 1.670] and probable major depression [OR 1.293, 95% CI 1.114, 1.500] at Year 2 compared to their peers a year later. Premium burdens were not associated with either outcome in Year 2.</p><p><strong>Conclusions: </strong>Out-of-pocket medical financial burdens in Year 1 were associated with worse mental health outcomes in Year 2. No association existed between premium burdens and mental health outcomes. Policymakers should consider how to address the nation's healthcare affordability crisis.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108555"},"PeriodicalIF":4.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Public perceptions of the 2025-2030 Dietary Guidelines for Americans. 公众对2025-2030年美国人膳食指南的看法。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-08-19 DOI: 10.1016/j.amepre.2026.108556
Julia A Wolfson, Cindy W Leung
{"title":"Public perceptions of the 2025-2030 Dietary Guidelines for Americans.","authors":"Julia A Wolfson, Cindy W Leung","doi":"10.1016/j.amepre.2026.108556","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108556","url":null,"abstract":"<p><strong>Introduction: </strong>The 2025-2030 Dietary Guidelines for Americans (DGAs), released in January 2026, generated substantial controversy among public health experts. However, little is known about public perceptions of the new DGAs.</p><p><strong>Methods: </strong>A nationally representative, web-based survey was fielded by Verasight from March 6-16, 2026. One-thousand US adults were randomized to complete the DGA perception questions. Respondents were asked four questions about their familiarity with the new DGAs, trust in the scientific basis of the DGAs, usefulness of the DGAs for decision-making, and support for incorporating environmental sustainability into future DGAs. Responses were analyzed overall using ordinal logistic regressions and chi-squared tests were used to assess differences across socio-demographic subgroups. All analyses were survey-weighted and were completed in 2026.</p><p><strong>Results: </strong>Overall, 50% of US adults did not trust that the recommendations in the new DGAs were based on sound scientific evidence; whereas, 35% did. Respondents were split between finding the DGAs useful (41%) versus not useful (44%), with 16% 'not sure'. Responses were significantly different (p's<0.01) based on education, household income, and political party affiliation with more unfavorable opinions about the new DGAs among those with higher education, higher income, and among Democrats and Independents. Support for including environmental sustainability into the DGAs (40%) was higher than opposition (24%), with 36.0% of adults being neutral.</p><p><strong>Conclusions: </strong>Results from this nationally representative survey showed US adults are divided about the trustworthiness and usefulness of the 2025-2030 DGAs, particularly along socio-economic and political lines which could have implications for dietary quality and health.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108556"},"PeriodicalIF":4.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Productivity losses from fatal drug overdoses in the United States. 美国致命药物过量导致的生产力损失。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-08-19 DOI: 10.1016/j.amepre.2026.108554
Ramesh Ghimire, Cora Peterson, Gery Guy, Curtis Florence
{"title":"Productivity losses from fatal drug overdoses in the United States.","authors":"Ramesh Ghimire, Cora Peterson, Gery Guy, Curtis Florence","doi":"10.1016/j.amepre.2026.108554","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108554","url":null,"abstract":"<p><strong>Introduction: </strong>Drug overdose remains a major public health challenge in the United States, yet contemporary national estimates of productivity losses from fatal drug overdoses are limited. This study estimated total and per-decedent life-years and productivity losses from fatal drug overdoses among U.S. adults in 2023.</p><p><strong>Methods: </strong>Drug overdose deaths were identified using 2023 National Vital Statistics System mortality file. Life-years lost were calculated by age and sex using U.S. life tables. Productivity losses were estimated from a societal perspective using human capital approach, valuing lost productivity as present value of expected lifetime productivity. Life-years and productivity losses were estimated for all overdose deaths, as well as opioid- and stimulant-involved overdose deaths.</p><p><strong>Results: </strong>In 2023, 103,936 overdose deaths occurred among U.S. adults, resulting in 3.79 million life-years lost and $194.51 billion in productivity losses. Opioid-involved overdoses resulted in 78,436 deaths, 2.95 million life-years lost, and $154.12 billion in productivity losses, and stimulant-involved overdoses accounted for 59,531 deaths, 2.13 million life-years lost, and $110.12 billion in productivity losses. Males accounted for most overdose deaths and associated losses. On average, 36.43 life-years were lost per overdose death, and per-decedent losses were greatest for opioid-involved overdoses (37.67 years). Synthetic opioids other than methadone (primarily illegally made fentanyl), psychostimulants, and cocaine were leading contributors to life-years and productivity losses.</p><p><strong>Conclusions: </strong>Fatal drug overdose imposes a substantial economic burden through lost life-years and productivity. Intervention efforts, particularly those addressing illegally made fentanyl, cocaine, and psychostimulants could potentially save lives and yield economic benefits.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108554"},"PeriodicalIF":4.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing predictive performance of two composite and four single fall risk assessment tools in community-dwelling older adults: A prospective study. 比较两种复合和四种单一跌倒风险评估工具在社区老年人中的预测性能:一项前瞻性研究。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-08-01 DOI: 10.1016/j.amepre.2026.108532
Weiqiang Li, Yanhong Fu, Min Zhao, David C Schwebel, Peishan Ning, Li Li, Peixia Cheng, Jiaqi Huang, Zhenzhen Rao, Guoqing Hu
{"title":"Comparing predictive performance of two composite and four single fall risk assessment tools in community-dwelling older adults: A prospective study.","authors":"Weiqiang Li, Yanhong Fu, Min Zhao, David C Schwebel, Peishan Ning, Li Li, Peixia Cheng, Jiaqi Huang, Zhenzhen Rao, Guoqing Hu","doi":"10.1016/j.amepre.2026.108532","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108532","url":null,"abstract":"<p><strong>Introduction: </strong>Many tools have been developed to assess fall risk and support fall prevention for older adults, but the authors are unaware of any study that compares the performance of predictive algorithms based on major composite assessment tools and commonly used single assessment tools. This study compares the predictive performance of the algorithms for two composite fall risk assessment tools and four single fall risk assessment tools among community-dwelling Chinese older adults.</p><p><strong>Methods: </strong>A 12-month prospective study was conducted between April 2023 and June 2024 in Changsha, China. Two major composite assessment tools (Stopping Elderly Accidents, Deaths & Injuries [STEADI] and World Falls Guidelines [WFG] algorithms) and four single assessment tools (Stay Independent Brochure Questionnaire [SIB], Falls Efficacy Scale International [FES-I], Home Falls and Accidents Screening Tool [HOME FAST], and Timed Up and Go Test [TUGT]) were included. Primary performance measures included area under the receiver operating characteristic curves (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).</p><p><strong>Results: </strong>Among the 1,428 enrolled older adults, 1,237 participants completed the study. All ten algorithms from the two composite assessment tools showed notably low AUC (0.527-0.575), sensitivity (11.3-36.5%) and PPV (12.7-31.7%), but acceptably high specificity (78.9-96.2%) and NPV (87.2-92.9%) to predict both falls and fall-related injuries throughout the 12-month follow-up period. Among the ten algorithms, WFG algorithm 3 exhibited the best performance in predicting both falls (AUC = 0.573, 95% CI: 0.544, 0.600) and fall-related injuries (AUC = 0.575, 95% CI: 0.546, 0.602). Compared to five algorithms based on four single assessment tools, WFG algorithm 3 did not demonstrate significantly superior performance (p>0.05).</p><p><strong>Conclusions: </strong>The performances of the optimal algorithm in predicting 12-month falls and fall-related injuries among older adults from the two composite risk assessment tools were not better than those from four common single risk assessment tools.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108532"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Outcomes and Behavioral Risk Factors Among US Law Enforcement Officers. 美国执法人员的健康结果和行为风险因素
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-07-30 DOI: 10.1016/j.amepre.2026.108529
Byunggu Kang, Yi-Fang Lu, Ethan Rogers
{"title":"Health Outcomes and Behavioral Risk Factors Among US Law Enforcement Officers.","authors":"Byunggu Kang, Yi-Fang Lu, Ethan Rogers","doi":"10.1016/j.amepre.2026.108529","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108529","url":null,"abstract":"<p><strong>Introduction: </strong>Violence prevention is widely recognized as a public health priority, and law enforcement officers' (LEOs) health is important for frontline response and prevention. Yet population-based estimates of LEO health remain limited and are rarely contextualized within the broader workforce. This study assesses health outcomes and behavioral risk factors among LEOs compared with other employed adults.</p><p><strong>Methods: </strong>This study analyzed 2018-2023 Behavioral Risk Factor Surveillance System data, linking public-use health and demographic data with restricted-use Industry and Occupation modules. Analyses were conducted in 2026. Because the analyses required restricted-use data, the data were accessed through the National Center for Health Statistics Research Data Center. The analytic sample included 646,581 employed adults from 45 states. LEOs were identified using police officers, correctional officers, and six other law-enforcement-related occupation categories. Self-reported health status, reported health conditions, and health behaviors were compared between LEOs and other employed adults, adjusting for sociodemographic characteristics.</p><p><strong>Results: </strong>Compared with other employed adults, LEOs reported a lower prevalence of fair or poor general health (aPR, 0.68; 95% CI=0.56, 0.82), frequent mental distress (aPR, 0.70; 95% CI=0.59, 0.83), and depressive disorder (aPR, 0.58; 95% CI=0.49, 0.68). However, LEOs reported a higher prevalence of overweight or obesity (aPR, 1.17; 95% CI=1.14, 1.20), diabetes (aPR, 1.25; 95% CI=1.00, 1.55), sleep deprivation (aPR, 1.31; 95% CI=1.22, 1.40), high blood pressure (aPR, 1.14; 95% CI=1.01, 1.29), smokeless tobacco use (aPR, 1.87; 95% CI=1.59, 2.20), and COVID-19 positivity (aPR, 1.24; 95% CI=1.12, 1.39).</p><p><strong>Conclusions: </strong>LEOs reported favorable overall and mental health profiles alongside specific vulnerabilities that may reflect occupational context such as shift work and frontline exposure. These findings underscore the need for identifying LEO-specific health risks when developing targeted prevention and intervention strategies.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108529"},"PeriodicalIF":4.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction models and nomograms for incident risk of chronic obstructive pulmonary disease in adults in Shanghai. 上海地区成人慢性阻塞性肺疾病事件风险预测模型和图。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-07-30 DOI: 10.1016/j.amepre.2026.108530
Xinyue Pang, Yonggen Jiang, Yixuan Zhang, Xin Yin, Yiling Wu, Qi Zhao, Zhongxing Sun, Genming Zhao, Yue Chen, Na Wang
{"title":"Prediction models and nomograms for incident risk of chronic obstructive pulmonary disease in adults in Shanghai.","authors":"Xinyue Pang, Yonggen Jiang, Yixuan Zhang, Xin Yin, Yiling Wu, Qi Zhao, Zhongxing Sun, Genming Zhao, Yue Chen, Na Wang","doi":"10.1016/j.amepre.2026.108530","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108530","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic obstructive pulmonary disease (COPD) is a major public health burden in China, but remains underdiagnosed, with most cases identified only after significant lung function decline. Effective, low-cost tools are therefore needed to identify high-risk individuals for targeted spirometry. This study developed risk prediction models and nomograms to guide personalized COPD prevention.</p><p><strong>Methods: </strong>A community-based cohort of 32,327 adults aged 40-74 years without COPD was enrolled in 2016 and followed until March 2024. COPD diagnosis was obtained from Shanghai Songjiang District Healthcare Information Platform. Stepwise Cox regression analyses were conducted to select predictors, including demographics, lifestyle, disease history, and medical resources use, for overall and sex-specific prediction models. Discrimination and calibration were assessed by C-index, AUC, and Brier score, with 10-fold cross-validation and sensitivity analysis for validation.</p><p><strong>Results: </strong>Over 7.0 years of follow-up, COPD incidence was 7.98 (95%CI: 7.61∼8.23) per 1,000 person-years, higher in men (10.60) than women (6.23). Sex, age, BMI, cooking habits, physical activity, smoking, occupational exposure, family history of respiratory diseases, other respiratory diseases, outpatient visits/year, and antibiotic prescriptions/year were significant predictors in the overall model. Male predictors additionally included central obesity, while female predictors additionally included fruit intake, history of tuberculosis and menopause. C-index was 0.780/0.770/0.781 (overall/male/female); Brier score was 0.035/0.044/0.028; Time-dependent AUCs at 1, 3, and 5 years ranged from 0.783 to 0.813, indicating good predictive performance over short, medium, and long term follow-up periods. Nomograms were created for overall, male and female populations.</p><p><strong>Conclusions: </strong>The study developed overall and sex-specific COPD risk prediction models with C-indices exceeding 70%. Corresponding nomograms provide practical tools for supporting routine COPD risk prediction to facilitate individualized preventive care.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108530"},"PeriodicalIF":4.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rural-Urban Differences in the Impact of a Medicare Opioid Safety Policy on Beneficiaries with Disabilities. 医疗阿片类药物安全政策对残疾受益人影响的城乡差异。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-07-30 DOI: 10.1016/j.amepre.2026.108537
Jonathan Kwak, Alyssa Burnett, Bryant Shuey, Fang Zhang, J Franklin Wharam, Hefei Wen
{"title":"Rural-Urban Differences in the Impact of a Medicare Opioid Safety Policy on Beneficiaries with Disabilities.","authors":"Jonathan Kwak, Alyssa Burnett, Bryant Shuey, Fang Zhang, J Franklin Wharam, Hefei Wen","doi":"10.1016/j.amepre.2026.108537","DOIUrl":"10.1016/j.amepre.2026.108537","url":null,"abstract":"<p><strong>Introduction: </strong>A 2019 Medicare opioid safety policy limited initial opioid duration to 7 days and long-term daily dosage to 90 morphine milligram equivalence (MME). Because effective pain management may vary by rurality, this study examined whether the policy differentially affected opioid prescribing among rural versus urban beneficiaries with disabilities.</p><p><strong>Methods: </strong>Deidentified claims data was used to gather a rolling cohort of Medicare Advantage beneficiaries with disabilities ages 18 to 64 from 2016 to 2021. Comparative interrupted time series were used in 2025 to analyze rural-urban differences in the duration and dosages of opioid fills for new-to-opioid beneficiaries, the target of the 7-day limit (N = 526,019 person-months), and the number of high-dosage episodes for long-term opioid beneficiaries, the target of the 90-MME limit (N = 3,312,161 person-months).</p><p><strong>Results: </strong>Despite significant reductions in initial opioid duration for both groups, the 7-day limit effect on initial opioid duration weakened over time (trend change: 0.17 [98.75% CI 0.04 to 0.30]) in the rural relative to the urban group. By the end of the study period, the rural group experienced 3.8 percentage points more initial opioid fills exceeding the 7-day limit (95% CI 0.4 to 7.3) than the urban group. Furthermore, the total dosage prescribed in subsequent fills among rural beneficiaries was 27.97 MME (95% CI -52.19 to -3.75) less than urban beneficiaries by the end of the study period. The rural and urban groups responded similarly to the 90-MME limitation.</p><p><strong>Conclusions: </strong>Rural relative to urban new-to-opioid beneficiaries with disabilities experienced a weakened effect on initial opioid duration after Medicare's 7-day limit, while receiving declining dosage in follow-up opioid fills, suggesting potential disparities in access to follow-up opioid prescriptions for rural versus urban beneficiaries with disabilities. Policymakers may consider more flexible opioid regulations and attention to alternative pain management for rural Medicare beneficiaries.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108537"},"PeriodicalIF":4.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Low-Data-Burden Vascular-Behavioral Profile for First-Pass Stratification of Later-Life Cognitive Decline Across International Aging Cohorts. 低数据负担的血管行为剖面在国际老龄化队列中对晚年认知能力下降的首次分层。
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-07-26 DOI: 10.1016/j.amepre.2026.108528
Linjiang Wei, Liangwen Zhang, Yuelong Ji, Ying Han, Ya Fang
{"title":"A Low-Data-Burden Vascular-Behavioral Profile for First-Pass Stratification of Later-Life Cognitive Decline Across International Aging Cohorts.","authors":"Linjiang Wei, Liangwen Zhang, Yuelong Ji, Ying Han, Ya Fang","doi":"10.1016/j.amepre.2026.108528","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108528","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive decline is a major prevention priority, but scalable approaches are needed to identify adults who may benefit from proportionate cognitive follow-up and vascular-behavioral prevention support. This study evaluated whether a low-data-burden vascular-behavioral profile supports first-pass cognitive-decline risk ordering across aging cohorts and where local recalibration is needed.</p><p><strong>Methods: </strong>Repeated cognition data from 2000-2025 were analyzed in UK Biobank, CHARLS, ELSA, HRS, NHATS, KLOSA, and CLHLS. Analyses were conducted in 2026. The 5-factor profile included hypertension, diabetes, smoking, physical inactivity, and obesity. Linear mixed models tested profile-by-time associations; random-slope models were fitted in major cohorts. A UK Biobank logistic reference model evaluated substantial decline, defined as a 5-year-equivalent decrease of at least 0.5 cohort-standardized SD. Discrimination and calibration were assessed.</p><p><strong>Results: </strong>Higher baseline burden was associated with faster global cognitive decline in UK Biobank, CHARLS, ELSA, and HRS, with similar random-slope estimates. For substantial decline, AUCs were 0.576 in UK Biobank, 0.603 in CHARLS, 0.666 in ELSA, and 0.643 in HRS. Absolute risk was underpredicted in external cohorts; observed versus predicted risks were 22.3% versus 12.8%, 19.4% versus 13.0%, and 20.9% versus 13.6% in CHARLS, ELSA, and HRS, respectively. The vascular-only score showed lower heterogeneity (I<sup>2</sup>=53.4%) than the behavior-only score (I<sup>2</sup>=88.4%).</p><p><strong>Conclusions: </strong>This simple profile supports low-data-burden first-pass cognitive-decline risk ordering. It may help prioritize higher-burden adults for proportionate follow-up and prevention support, with local recalibration required before absolute probabilities guide individual decisions.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108528"},"PeriodicalIF":4.7,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2025 AJPM Reviewer List – Top Reviewers 2025 AJPM审稿人名单-顶级审稿人
IF 4.7 2区 医学
American Journal of Preventive Medicine Pub Date : 2026-07-01 Epub Date: 2026-06-19 DOI: 10.1016/S0749-3797(26)00169-8
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