American Journal of Preventive Medicine最新文献

{"title":"Leisure-time and occupational physical activity and risk of long-term sickness absence from mental disorders: a prospective cohort study.","authors":"Keisuke Kuwahara, Tohru Nakagawa, Shuichiro Yamamoto, Toru Honda, Atsushi Goto, Maki Konishi, Tetsuya Mizoue","doi":"10.1016/j.amepre.2026.108563","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108563","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined whether leisure-time physical activity (LTPA), occupational physical activity (OPA), and their combination are associated with risk of mental disorder-related long-term sickness absence (LSA).</p><p><strong>Methods: </strong>This cohort study included 38,120 Japanese employees aged 20-59 years from the Japan Epidemiology Collaboration on Occupational Health Study. Baseline assessments were conducted primarily in 2011, with follow-up from 2012 through 2024. LTPA and OPA levels were self-reported at baseline. LSA (≥30 consecutive days) due to mental disorders was medically certified by physicians. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, occupational, and health-related factors including depressive symptoms.</p><p><strong>Results: </strong>During a mean follow-up of 9.2 years, 1,032 participants (2.7%) experienced LSA from mental disorders. LTPA showed an inverse but non-linear association with LSA risk (p for non-linearity=0.042) with lower risk apparent at low activity; activity below recommended levels was associated with reduced risk (HR 0.72, 95% CI 0.55-0.93). The inverse association of LTPA was evident when restricted to depressive disorders as the outcome (p for trend=0.029) and among sedentary workers (p for trend=0.027), although the interaction by OPA was non-significant (p=0.14). Higher OPA was linearly associated with lower risk (HR for physically active vs sedentary work = 0.50, 95% CI 0.37-0.69; p for linear trend<0.001).</p><p><strong>Conclusions: </strong>LTPA showed inverse associations with mental disorder-related LSA, most evident for depressive disorders. Higher OPA was associated with reduced risk of mental disorder-related LSA, not clearly supporting the physical activity paradox.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108563"},"PeriodicalIF":4.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide death following a crisis line contact: The importance of treatment initiation and continuation.","authors":"Peter C Britton, Ahmed Mohamed, Tracy Stecker, Wilfred R Pigeon","doi":"10.1016/j.amepre.2026.108564","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108564","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to determine whether initiating or connecting with behavioral health care (BHC; mental health and substance use) following a Veterans Crisis Line (VCL) contact was associated with reduced likelihood of suicide.</p><p><strong>Methods: </strong>A retrospective cohort design was used to examine the association of BHC in the month (0-30 days) following a crisis line contact (i.e., calls, texts, and chats) with suicide death over a year (days 31-365) among 317,515 VCL contacts from 2015-2019. Contacts were divided into 1) non-BHC users, 2) BHC initiators, 3) BHC continuers, and 4) BHC discontinuers. Logistic regression was used with BHC discontinuers as reference. Secondary analyses were conducted with any health care (HC).</p><p><strong>Results: </strong>Non-BHC users, adjusted odds ratio (AOR) (95% CI) = 0.29 (0.23-0.38), BHC initiators, AOR (95%CI) = 0.46 (0.35-0.61), and BHC continuers, AOR = 0.63 (0.47-0.83), were less likely to die by suicide than those who discontinued BHC. Non-HC users, AOR (95% CI) = 0.22 (0.16-0.29), HC initiators, AOR (95%CI) = 0.34 (0.25-0.45), and HC continuers, AOR = 0.48 (0.36-0.64), were also less likely to die by suicide than HC discontinuers.</p><p><strong>Conclusions: </strong>Initiating and continuing with BHC following a crisis line contact was associated with a lower likelihood of suicide than discontinuing with BHC. Veterans who never used BHC may include one or more subpopulations at low suicide risk. Those who discontinue BHC may be at high suicide risk, suggesting a need for additional research and possible intervention. Similar associations were found for any HC.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108564"},"PeriodicalIF":4.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength across generations: An analysis of 1,158,069 Japanese children and adolescents from 57 years of national surveillance (1967-2023).","authors":"Tetsuhiro Kidokoro, Naruki Kitano, Natsuko Imai, Tomoko Aoyama, Koya Suzuki, Costan G Magnussen, Justin J Lang, Grant R Tomkinson","doi":"10.1016/j.amepre.2026.108566","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108566","url":null,"abstract":"<p><strong>Introduction: </strong>Handgrip strength (HGS) is a widely used indicator of muscular strength that offers important insights into population health. While the literature has examined period effects-year-by-year changes in HGS- the authors are unaware of any study that has systematically investigated cohort effects, which may offer a more nuanced understanding of the generational shifts in HGS. This study aimed to examine the generational differences in the development of HGS among Japanese children and adolescents.</p><p><strong>Methods: </strong>Repeated, nationally-representative, annual, cross-sectional data on HGS were obtained from the Japan Sports Agency, covering 1,158,069 Japanese children and adolescents aged 10-17 years between 1967 and 2023. Temporal trends in absolute and relative HGS were estimated using sample-weighted regression models relating the year of testing to the mean HGS. To assess generational differences in HGS development, 10 synthetic birth cohorts were constructed at 5-year intervals from 1960 to 2005. Each cohort was tracked longitudinally in a repeated cross-sectional manner from age 10 to 17, allowing comparisons of both the annual strength velocity and the age at peak strength velocity across cohorts.</p><p><strong>Results: </strong>A small but consistent decline in both absolute and relative HGS was observed over the 57-year period, with more pronounced declines observed since the 1990s (mean change per decade: boys, -1.6% [95% CI: -1.9%, -1.3%]; girls, -1.4% [95% CI: -1.7%, -1.2%]). Cohort analyses further revealed that the annual strength velocity was consistently lower at all ages in more recent cohorts (e.g., 2005 birth cohort) than in earlier cohorts (e.g., 1960 birth cohort), although the age at peak strength velocity remained steady.</p><p><strong>Conclusions: </strong>These findings suggest that children's HGS has progressively declined across generations, with more recent cohorts showing smaller age-related improvement. Given the well-established associations between HGS and multiple health outcomes, the observed decrease in HGS suggests a corresponding decline in population health.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108566"},"PeriodicalIF":4.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the food environment and the risk of ischemic stroke.","authors":"Christopher J Becker, Mohanad Ahmad, Jocelyn Ra, Madeline Kwicklis, Jiacong Du, Chen Chen, Hely D Nanavati, Leanna Delhey, Lynda D Lisabeth, Lewis B Morgenstern","doi":"10.1016/j.amepre.2026.108567","DOIUrl":"10.1016/j.amepre.2026.108567","url":null,"abstract":"<p><strong>Introduction: </strong>A healthy diet is critical for stroke prevention. The role of the food environment is less clear. This study evaluated the association between the food environment and incident ischemic stroke in a large population-based study.</p><p><strong>Methods: </strong>All first-ever ischemic strokes among residents of Nueces County, Texas from 2000-2023 were identified and geocoded by patient home address. The primary exposure was the modified retail food environment index (mRFEI), reflecting the mix of healthy and unhealthy food sources in each census tract (range 0-1, higher=healthier, modeled continuously), obtained from the National Neighborhood Data Archive. Population data were obtained from the US Census and American Community Survey. Stroke incidence rates were estimated using Poisson regression on cross-classified aggregate data. Covariates included age, sex, ethnicity, and neighborhood socioeconomic status (nSES).</p><p><strong>Results: </strong>A total of 6,716 first-ever ischemic strokes occurred in the study region from 2000-2023. Unexpectedly, higher (healthier) mRFEI values were associated with lower (poorer) nSES. Before adjustment, there was a marginal association between higher mRFEI scores and greater stroke incidence (incidence rate ratio [IRR] of 75^th vs 25^th percentile=1.07; 95%CI=0.99, 1.15; p=0.07). After adjustment, this association was attenuated and not statistically significant (IRR=1.00, 95%CI=0.95, 1.06; p=0.91). Post-hoc analyses evaluated healthy and unhealthy food sources separately and expanded the neighborhood to include adjacent tracts, yielding similar results.</p><p><strong>Conclusions: </strong>No association was observed between the food environment and stroke incidence. These results add to a growing literature suggesting that improved access to healthy food sources alone may not be sufficient to reduce incidence of stroke and other cardiovascular events.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108567"},"PeriodicalIF":4.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity and Recreation for Kids Study (PARKS): Park-intensive community outreach for child physical activity group-randomized controlled trial.","authors":"Simone A French, Susan M Mason, Katherine R Hendel, Daheia J Barr-Anderson, Natalie Scholz, Dawn Nederhoff","doi":"10.1016/j.amepre.2026.108565","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108565","url":null,"abstract":"<p><strong>Background: </strong>Park use among urban children can contribute to higher child physical activity (PA), yet most children do not use parks or park sports programs. The PARKS (Physical Activity and Recreation for Kids Study) group randomized controlled trial evaluated the effect of park-level intensive community outreach on change in child MVPA, light and sedentary activity. It was hypothesized that children in the intervention parks would increase their MVPA and decrease their sedentary activity compared to children in the usual parks.</p><p><strong>Methods: </strong>Twenty urban parks were randomized to intensive park outreach or usual outreach. Intervention included monthly meetings with park managers and community partner organizations to support existing and create new community marketing efforts. An evaluation cohort of 430 parent-child dyads who resided near these parks completed PA measures at baseline and 12 months. Generalized linear mixed models estimated mean differences (95% confidence intervals) between treatment groups on child and parent PA outcomes at 12 months.</p><p><strong>Results: </strong>Cohort retention was 90% at 12 months. No significant intervention effects were observed on child MVPA or sedentary time. Children in the intervention parks showed significantly less decline in their accelerometry-based light PA on average by 9.6 mins/day (95% Confidence Interval: 1.4, 17.7) compared with children in the control group. Parents in the intervention parks showed significantly less increase in accelerometry-based sedentary activity on average -27.3 mins/day (95% Confidence Interval: -52.9, -1.6) compared with parents in the control group.</p><p><strong>Conclusion: </strong>Park-based intensive community outreach may prevent age-related declines in children's light PA and may reduce increases in parents' sedentary activity. Future park-based interventions must amplify community outreach efforts to strengthen their impact on child PA.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108565"},"PeriodicalIF":4.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and Stage Trends in Early-Onset Colorectal Cancer Incidence Before and After the USPSTF 2021 Update.","authors":"Todd Burus, Jason Semprini","doi":"10.1016/j.amepre.2026.108568","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108568","url":null,"abstract":"<p><strong>Introduction: </strong>Early-onset colorectal cancer (CRC) incidence has increased in the US, raising concern about changing risk among adults aged 20-49 years. In 2021, the US Preventive Services Task Force lowered the recommended starting age for average-risk CRC screening from 50 to 45 years. This study examined whether CRC incidence trends were concentrated among adults newly eligible for screening.</p><p><strong>Methods: </strong>Analyzing the latest SEER data for malignant CRCs from 2004-2023, the study estimated annual percentage changes (APCs) using log-linear regression for adults aged 20-49 years overall and for age groups 20-44, 45-49, and 50-54 years, further stratified by early-stage and late-stage diagnosis. Joint-Point analyses were performed as a sensitivity check.</p><p><strong>Results: </strong>In 2023, there were 10,395 early-onset CRC diagnoses, corresponding to an incidence rate of 18.1 per 100,000. Overall early-onset CRC incidence increased by 1.95% per year in 2004-2019 and 8.41% per year in 2021-2023. The largest recent increase occurred among adults aged 45-49 years, whose all-stage APC rose from 1.31% in 2004-2019 to 14.38% in 2021-2023. Among adults aged 45-49 years, early-stage CRC increased by 32.14% per year in 2021-2023, compared with 0.12% per year in 2004-2019; late-stage CRC increased by 3.29% per year in 2021-2023. Trends among adults aged 20-44 and 50-54 years were comparatively stable, but rising.</p><p><strong>Conclusions: </strong>Recent acceleration in early-onset CRC incidence was concentrated among adults aged 45-49 years, especially early-stage diagnoses, suggesting increased detection after expanded screening eligibility.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108568"},"PeriodicalIF":4.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Financial Burdens and Later Risks of Adult Psychological Distress (2014-2023).","authors":"Michael Caniglia, Laura J Chavez","doi":"10.1016/j.amepre.2026.108555","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108555","url":null,"abstract":"<p><strong>Introduction: </strong>Research suggests that medical debt and difficulty paying medical bills are associated with worse mental health. However, limited research examines the longitudinal association between medical spending as a proportion of income and later mental health.</p><p><strong>Methods: </strong>Using a series of two-year panels from the US Medical Expenditure Panel Survey-Household Components (2014-2023) (N=60,391 adults), this study employed longitudinal logistic regression models to examine the relationship between out-of-pocket and premium burdens in Year 1 and mental health outcomes in Year 2. Symptoms of severe psychological distress and probable major depression were measured using the Kessler-6 Severe Psychological Distress Scale and the Patient Health Questionnaire-2, respectively.</p><p><strong>Results: </strong>Among the study population, 63% of adults identified as non-Hispanic White, 16% as Hispanic, 12% as non-Hispanic Black, 6% as non-Hispanic Asian and Pacific Islander, 2% as non-Hispanic Multiracial and 1% as non-Hispanic American Indian or Alaska Native. The sample was 52% female. After controlling for covariates, adults with out-of-pocket burdens in Year 1 faced increased odds of both severe psychological distress [OR 1.405; 95% CI=1.182, 1.670] and probable major depression [OR 1.293, 95% CI 1.114, 1.500] at Year 2 compared to their peers a year later. Premium burdens were not associated with either outcome in Year 2.</p><p><strong>Conclusions: </strong>Out-of-pocket medical financial burdens in Year 1 were associated with worse mental health outcomes in Year 2. No association existed between premium burdens and mental health outcomes. Policymakers should consider how to address the nation's healthcare affordability crisis.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108555"},"PeriodicalIF":4.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the cost avoidance associated with a regional poison control center.","authors":"Kangho Suh, Siang-Hao Cheng, Michael Lynch, Joshua Shulman, Amanda Korenoski","doi":"10.1016/j.amepre.2026.108549","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108549","url":null,"abstract":"<p><strong>Objective: </strong>Poison control centers (PCCs) play a pivotal role in managing toxicologic exposures, often preventing unnecessary healthcare utilization. However, comprehensive economic evaluations of individual PCCs that reflect post-COVID-19 pandemic care-seeking behaviors and current healthcare costs remain limited. The objective of this study was to estimate the healthcare cost avoidance associated with Pittsburgh's PCC consultation using real-world poison exposure data and a decision analytic model.</p><p><strong>Methods: </strong>A cost-avoidance model was developed comparing clinical trajectories and costs for cases with and without PCC consultation. Patient pathways were informed by National Poison Data System (NPDS) records of calls managed by the Pittsburgh Poison Center (2020-2024), and cost inputs were drawn from the literature. A probability of trajectory change was applied to reflect uncertainty in the effectiveness of PCCs. An evidence-based hospital length-of-stay reduction of 11.7 hours from a published study was applied to relevant pathways. One-way and probabilistic sensitivity analyses were conducted, and scenario analyses explored assumptions for key model branches.</p><p><strong>Results: </strong>In the base case, the average healthcare cost per patient was $2,438 with PCC consultation and $3,975 without. Annual PCC operating costs were $2.74 million with 24,481 annual regional consults, resulting in a net annual cost avoidance of $34.87 million (95% credible interval: $34.62 million, $42.88 million), corresponding to a benefit-to-cost ratio of approximately 12.75:1 (a net return of $11.75 in avoided healthcare costs for every $1 spent on PCC operations). Sensitivity analysis identified patient behavior assumptions, specifically the likelihood of contacting a primary care provider or visiting the emergency department, as the most influential parameters.</p><p><strong>Conclusion: </strong>PCC consultations were associated with substantial healthcare cost avoidance by averting unnecessary utilization and shortening hospital stays. By integrating real-world data and explicitly modeling counterfactual pathways, this analysis provides robust evidence supporting sustained investment in PCC infrastructure as a high-value public health intervention.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108549"},"PeriodicalIF":4.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing uptake of lung cancer screening through a patient 'nudge': A randomized pragmatic trial.","authors":"Nikki M Carroll, Andrew J Maclennan, Kris F Wain, Brian Hixon, Julie Steiner, Debra P Ritzwoller","doi":"10.1016/j.amepre.2026.108552","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108552","url":null,"abstract":"<p><strong>Introduction: </strong>Population-level benefits of lung cancer screening (LCS) depend upon high participation, yet uptake remains low because of patient-, provider-, and system-level barriers. This study evaluated whether a pre-visit patient \"nudge\" increases LCS uptake.</p><p><strong>Study design: </strong>Patients were randomized by birth-month into intervention (IG) and usual care (UC) groups.</p><p><strong>Setting/participants: </strong>Kaiser Permanente Colorado patients eligible for LCS who had not completed baseline LCS low dose computed tomography (LCS-LDCT) screening and had a scheduled primary care physician (PCP) visit between 3/19/2024 and 10/8/2024 were randomized. Data were collected through 11/20/2024.</p><p><strong>Intervention: </strong>Patients in the IG received an electronic or mailed letter encouraging LCS discussion with their PCP.</p><p><strong>Main outcome: </strong>Receipt of an LCS-LDCT order.</p><p><strong>Results: </strong>Analyses were conducted in 2024-2026. A total of 894 patients were randomized: 456 (51%) to IG and 438 (49%) to UC. Overall, 728 completed their visit (359 (49%) IG and 369 (51%) UC; P=0.69). Among those completing their visit, same-day LCS-LDCT ordering was similar (15% vs 18%; P=0.30) as were LCS-LDCT completion rates (7.0% vs 7.2% of completed visits [P=0.92]; 39% vs 48% of orders [P=0.34]). By follow-up end, more UC patients received an LCS-LDCT order (41% vs 38%; P=0.36).</p><p><strong>Conclusions: </strong>A low-intensity pre-visit patient nudge did not increase LCS-LDCT orders but was feasible to implement and allowed outreach strategy adaptations. Future refinements should optimize timing and integrate outreach with existing patient communications like appointment reminders to improve patient reach and engagement with patient-provider SDM discussions.</p><p><strong>Trial registration: </strong>This study was registered at www.</p><p><strong>Clinicaltrials: </strong>Gov (NCT06474611).</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108552"},"PeriodicalIF":4.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity-related productivity losses from major depressive disorder among U.S. adults.","authors":"Ramesh Ghimire, Cora Peterson, Eric Carbone, Elizabeth Swedo, Curtis Florence","doi":"10.1016/j.amepre.2026.108553","DOIUrl":"https://doi.org/10.1016/j.amepre.2026.108553","url":null,"abstract":"<p><strong>Introduction: </strong>Major depressive disorder (MDD) is a leading cause of disability and functional impairment, yet contemporary national estimates of productivity losses from MDD among U.S. adults remain limited. This study estimated the annual cost of morbidity-related productivity losses attributable to MDD among U.S. adults aged ≥18 years, in total and per-affected adult, in 2024.</p><p><strong>Methods: </strong>Morbidity-related productivity losses attributable to MDD among U.S. adults were estimated using a human capital approach. Multiple data sources, including pooled data from the 2022-2024 National Survey on Drug Use and Health and published literature, were used to quantify costs related to absenteeism, presenteeism, household productivity loss, and inability to work. All costs were expressed in 2024 USD, and analyses were conducted in 2026.</p><p><strong>Results: </strong>Total annual cost of morbidity-related productivity losses attributable to MDD among U.S. adults were estimated approximately $119 billion (95% prediction interval [PI]: $81-$167 billion) or at $5,824 (PI: $4,636-$7,106) per-affected adult in 2024. Inability to work costs accounted for 44% of total productivity losses, followed by presenteeism (33%), absenteeism (18%), and household productivity loss (5%). Total productivity loss costs and per-person loss costs differed by sex.</p><p><strong>Conclusions: </strong>MDD-related productivity losses impose a substantial economic burden in the United States. Because these costs are driven by both MDD prevalence and the amount of lost productive time, implementation of evidence-based mitigation and treatment strategies could reduce the societal burden of depression and yield meaningful cost savings for the U.S. economy.</p>","PeriodicalId":50805,"journal":{"name":"American Journal of Preventive Medicine","volume":" ","pages":"108553"},"PeriodicalIF":4.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}