Behavioural Neurology最新文献

{"title":"Supplementation of the Probiotic LLH135 Reduces Oxidative Stress in a Model of Hemiparkinsonism.","authors":"Mario E Flores-Soto, Angelica Y Nápoles-Medina, Aldo R Tejeda-Martínez, Josué R Solís-Pacheco, Verónica Chaparro-Huerta, Juan E Gutiérrez-Sevilla, Blanca R Aguilar-Uscanga","doi":"10.1155/bn/8401392","DOIUrl":"https://doi.org/10.1155/bn/8401392","url":null,"abstract":"<p><p>Oxidative stress and neuroinflammation are considered as the two main etiological reasons behind idiopathic Parkinson's disease (PD). Nevertheless, the actual treatments are focused on improving motor symptoms by restoring dopamine (DA) presence, leaving said causes unattended. Probiotics could be a promising strategy for the improvement of these physiological features behind the disease and therefore constitute a complementary treatment for those having PD. This study evaluated the effect of the oral administration of a probiotic bacteria mixture from 3 strains of <i>Limosilactobacillus fermentum</i> LH01<i>, Limosilactobacillus reuteri</i> LH03, and <i>Lactiplantibacillus plantarum</i> LH05 (LLH135), of human milk origin, for 4 weeks, on mice under the hemiparkinsonism model of intrastriatal administration of 6-hidroxidopamine (6-OHDA). We measured total antioxidant capacity (TAC), super oxide dismutase (SOD) activity, and 8-deoxyguanosine (8-OHdG) regarding oxidative stress. Concerning neuroinflammation, immunoreactivity for GFAP, IBA-1, and CD68 was measured by immunohistochemistry and the latter markers corroborated in colocalization with immunofluorescence to assess activated microglia. The probiotic mixture diminished the oxidative stress features of SOD activity as well as 8-OHdG generated by the model of hemiparkinsonism. These effects were accompanied as well by the dampening of the glial immunoreactivity and colocalization of IBA-1 and CD68 that were present under the model. Our findings suggest that the administration of the probiotic LLH135 exerts neuroprotective effects by promoting an antioxidant response which could be explained by the modulation of the response from glial cells to dopaminergic neuronal damage induced with 6-OHDA.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"8401392"},"PeriodicalIF":2.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Sleep-Disordered Breathing Events Using Latent Profile Analysis.","authors":"Marina Weinberger, Anwar E Ahmed, Ahmed Almuttari, Abdullah Al-Harbi, Hani A Alsaigh, J Kent Werner, Hamdan Al-Jahdali","doi":"10.1155/bn/8848485","DOIUrl":"https://doi.org/10.1155/bn/8848485","url":null,"abstract":"<p><p>The clinical utility of the ratio of the apnea-hypopnea index (AHI) occurring during rapid eye movement (REM) and non-REM (NREM) sleep (AHI_REM/AHI_NREM ratio) has been debated. We investigated the heterogeneity of REM and NREM sleep behaviors to identify unobserved distinct subtypes of sleep-disordered breathing (SDB) and examine their demographic and clinical features. The present study used a sample of 3626 adult patients who underwent diagnostic polysomnography evaluations at the Sleep Disorders Center of King Abdulaziz Medical City in Riyadh, Saudi Arabia. Latent profile analysis was performed to categorize subjects into distinct profiles of SDB based on AHI_REM, AHI_NREM, and AHI_REM/AHI_NREM ratio. A multinomial logistic model estimated the odds ratio of SDB profiles. Four distinct subtypes of SDB were identified: Class I (low AHI_REM; 75.9%) included patients with normal SDB events during REM sleep, serving as the reference group; Class II (REM-OSA, 1.2%) included patients with high AHI during REM sleep but lowest AHI during NREM sleep, resulting in the largest AHI_REM/AHI_NREM ratio; Class III (AHI_NREM < 30 events per hour, 17.4%); and Class IV (AHI_NREM ≥ 30 events per hour, 5.5%). Compared to Class I, factors related to Class IV included older age, high BMI, large neck circumference, hypertension, reduced total sleep time, reduced REM sleep, poor sleep efficiency, high desaturation index, low SpO2, high arousal index, and high Epworth Sleepiness Scale. As hypothesized, the study characterized several subtypes of SDB based on the AHI_REM, AHI_NREM, and their ratio (AHI_REM/AHI_NREM) in a large cohort and identified their demographic and clinical features. These subtypes might be clinically useful for defining SDB among adult patients referred to sleep clinics who may have varying responses to treatment depending on their subtype of the disease.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"8848485"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Neutrophil Percentage-to-Albumin Ratio and Depression in Middle-Aged and Elderly Adults: A National Study.","authors":"Leiyong Zhao, Chengjun Li, Hequn Lv, Chunli Zeng, Yongjun Peng","doi":"10.1155/bn/4199054","DOIUrl":"10.1155/bn/4199054","url":null,"abstract":"<p><p><b>Background:</b> The association between inflammatory markers and depression has garnered increasing attention. The neutrophil percentage-to-albumin ratio (NPAR) is an emerging inflammatory marker, but its association with depression in middle-aged and elderly adults was not previously explored. The purpose of this study was to investigate the association through a national study in the United States. <b>Methods:</b> All study data were weighted to ensure representativeness. Multivariate logistic regression models were applied to explore the independent relationship of NPAR with depression in middle-aged and elderly adults. Restricted cubic splines were employed to examine potential nonlinear association, with turning points calculated using a recursive algorithm upon detecting nonlinearity. Stratified analyses and interaction tests were conducted to explore subgroup differences. <b>Results:</b> In the model adjusted for all confounding factors, no significant relationship was found between NPAR and depression in middle-aged and elderly adults [1.02 (0.92, 1.12)]. Further sensitivity analysis indicated a potential U-shaped relationship between NPAR and depression in middle-aged and elderly adults, with the OR (95% CI) of 0.74 (0.60, 0.92), 0.87 (0.70, 1.08), 0.92 (0.72, 1.19) for Q2, Q3, and Q4, respectively, compared to Q1. The U-shaped association was confirmed by the restricted cubic spline. Subsequent analysis identified an inflection point at 14.05, revealing inverse relationships before and after this point. Subgroup analysis indicated sex differences in this association. <b>Conclusion:</b> This large-scale cross-sectional study identified a U-shaped association between NPAR and depression in American middle-aged and elderly adults.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"4199054"},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.","authors":"Peile Liu, Jian Hu, Beiyao Gao, Yan Hua, Ying Xing, Yulong Bai, Nan Liu","doi":"10.1155/bn/3631524","DOIUrl":"10.1155/bn/3631524","url":null,"abstract":"<p><p>For decades, scientists have explored the patterns of neural network remodeling that occur after a stroke. Several studies have shown that both motor cortexes (MCs) undergo crucial remodeling after cerebral ischemia. However, the mechanism by which corticofugal fibers are remodeled is not well understood. Therefore, this study was aimed at investigating the changes in the bilateral red nucleus (RN) and MC-RN projections during recovery from a large-area stroke in a rat stroke model with or without constraint-induced movement therapy (CIMT). A large-area middle cerebral artery occlusion (MCAO) model was established in rats using the Longa method. CIMT was initiated 7 days after MCAO and continued for 1, 2, or 3 weeks. Rats in the control group underwent spontaneous recovery. Locomotor impairment was evaluated using the CatWalk automated gait analysis system, and overall neurological function was evaluated with the modified neurological severity score. Bilateral MC-RN projections were visualized by labeling fiber tracts with an anterograde tracer. Postsynaptic density 95 (PSD95), growth-associated protein 43 (GAP43), and synaptophysin expression levels in the RN were detected using western blotting and immunohistochemistry. The results showed that CIMT promoted motor recovery after a stroke, increased levels of GAP43 and PSD95 in the contralesional but not ipsilesional RN, and increased projections from the MC to the bilateral RN. Thus, CIMT promotes neuroplasticity after a large-area stroke by stimulating axon outgrowth, improving postsynaptic membrane function in the contralesional RN, and increasing bilateral projections of the MC-RN. These results provide evidence for the therapeutic efficacy of CIMT in restoring motor function and help with understanding RN plasticity after a large-area stroke.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"3631524"},"PeriodicalIF":2.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Neuroprotective Potential of <i>Sutherlandia frutescens</i> in a Rotenone-Induced Rat Model of Parkinson's Disease.","authors":"Lilit Darbinyan, Karen Simonyan, Larisa Manukyan, Vaghinak Sarkisian, Lusya Hovhannisyan, Lilia Hambardzumyan","doi":"10.1155/bn/6606560","DOIUrl":"https://doi.org/10.1155/bn/6606560","url":null,"abstract":"<p><p><i>Sutherlandia frutescens</i> (<i>SF</i>) is a plant used traditionally in South Africa for various health conditions, including neurological disorders. Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra, resulting in motor symptoms. Rotenone, a pesticide, has been linked to PD-like symptoms in both in vitro and in vivo studies. However, <i>SF</i>-specific effects of <i>SF</i> on PD-related symptoms have not been extensively studied. This study was aimed at investigating the potential neuroprotective effects of <i>SF</i> against rotenone-induced PD using in vivo electrophysiological recordings from the hippocampus and an open-field test to assess motor behavior. Rats were divided into three groups: a control group receiving sunflower oil, a rotenone group treated with rotenone (2.0 mg/kg), and an <i>SF</i> group treated with hydroponically grown <i>SF</i> extract. Electrophysiological recordings from the hippocampus were conducted to assess neuronal activity, and an open-field test was used to evaluate motor behavior. Rats treated with <i>SF</i> exhibited significantly higher motor activity compared to both the sunflower oil and rotenone groups, suggesting an activating effect of <i>SF</i> on motor behavior. In contrast, the rotenone group displayed reduced activity levels and exploratory behavior, highlighting the suppressive impact of rotenone on motor function. These findings suggest that <i>SF</i> modulates hippocampal neuronal activity and may offer neuroprotective benefits against rotenone-induced PD-like symptoms. <i>SF</i>, a plant with traditional medicinal applications, shows potential in modulating motor behavior and hippocampal neuronal activity in a rotenone-induced PD model. Further studies are needed to clarify the underlying mechanisms and evaluate the clinical relevance of <i>SF</i> in PD management.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"6606560"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Comorbid With Depression: A Bibliometric and Visualized Analysis of Research Trends and Hotspots From 2000 to 2024.","authors":"Junting Chen, Cai Li, Ling Chen, Ziyi Zhao, Yongsu Zheng, Xiaoyan Yang, Hao Huang, Renli Deng","doi":"10.1155/bn/7106629","DOIUrl":"https://doi.org/10.1155/bn/7106629","url":null,"abstract":"<p><p><b>Background:</b> Sleep disorders, such as insomnia, are pervasive and frequently comorbid with depression, significantly affecting the quality of life of patients. Insomnia is characterized by difficulty initiating or maintaining sleep, which leads to impairment. Depression is characterized by persistent sadness and loss of interest, and it often features symptoms of insomnia. Understanding their interaction will be done for treatment strategies concerning both disorders. Despite the existence of extensive studies on insomnia and depression, there is a significant gap in bibliometric analysis specifically addressing the comorbidity of these two conditions. <b>Objectives:</b> This study is aimed at conducting a bibliometric analysis of research in insomnia comorbid with depression (ICD) to identify research trends, collaboration patterns, influential works, and hotspots. <b>Methods:</b> The study involved performance analysis to evaluate research productivity and trends, science mapping to visualize the intellectual structure and thematic evolution of the field, and network analysis to examine research collaboration and knowledge structure. Tools such as VOSviewer, CiteSpace, and GraphPad Prism were utilized for data analysis. <b>Results:</b> A total of 1624 publications on the comorbidity of insomnia and depression from 2000 to 2024 were included, encompassing both articles and reviews. Publication volume showed a steady growth from 2000 to 2008, followed by a significant increase from 2019 onward. The United States was the most productive country, followed by China. Key authors such as Allison G. Harvey, Charles M. Morin, and Daniel J. Buysse have made substantial contributions to the field. Major influential journals included <i>Sleep Medicine</i>, <i>Journal of Affective Disorders</i>, and <i>Frontiers in Psychiatry</i>. Research trends identified included the exploration of neurobiological mechanisms, cognitive behavioral therapy for insomnia (CBT-i), and personalized treatment approaches. <b>Conclusion:</b> This bibliometric analysis provides valuable insights into the evolving landscape of research on ICD. Future research should focus on personalized, multimodal interventions, expanding the application of CBT-i, exploring neurobiological mechanisms, and improving patients' quality of life through integrated treatment strategies.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"7106629"},"PeriodicalIF":2.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dietary Inflammatory Index and Depression Symptoms in Chronic Kidney Disease.","authors":"Rui Huang, Qixia Zhu","doi":"10.1155/bn/9253956","DOIUrl":"https://doi.org/10.1155/bn/9253956","url":null,"abstract":"<p><p><b>Objective:</b> The study is aimed at investigating the relationship between dietary inflammatory index (DII) score and depression symptoms in chronic kidney disease (CKD), exploring its potential role as an indicator of depression risk and offering new insights into dietary interventions for this vulnerable population. <b>Materials and Methods:</b> The cross-sectional investigation included CKD patients aged ≥ 18 in the 2007-2018 National Health and Nutrition Examination Survey. The Patient Health Questionnaire-9 (PHQ-9) was administered to evaluate depression symptoms. Dietary information was obtained from a 24-h dietary recall interview. The relationship between DII and depression was explored through weighted univariate and multivariate logistic regression models, adjusting for relevant covariates identified via backward selection. Results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). To further investigate the association, restricted cubic spline (RCS) and subgroup analyses were conducted. <b>Results:</b> Totally, 489 (11.55%) patients with CKD had depression symptoms. A high DII score was linked to elevated depression symptoms incidence in CKD (OR: 1.67, 95% CI: 1.06-2.65). Adjusting all covariates, the relationship between DII score and depression symptoms still existed in patients aged ≥ 60 years (OR: 1.80, 95% CI: 1.16-2.79), males (OR: 2.05, 95% CI: 1.16-3.59), smokers (OR: 1.70, 95% CI: 1.06-2.75), and those without sleep disorders (OR: 1.81, 95% CI: 1.01-3.23). <b>Conclusion:</b> DII score was associated with depression symptoms in patients with CKD. The findings suggest that diet plays a role in mental health, particularly in chronic conditions like CKD. The results underscore the importance of exploring anti-inflammatory dietary interventions to mitigate depression symptoms in this population. Further longitudinal research is necessary to establish causality and determine the efficacy of targeted dietary modifications in CKD patients with depression. <b>Limitations:</b> As a cross-sectional study, causality cannot be inferred from these findings. Additionally, the reliance on self-reported dietary data may introduce bias, and unmeasured confounders could influence the observed associations.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"9253956"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Relationship Between Cortical Thickness and Sensory Motor Symptoms in Adults on the Autism Spectrum.","authors":"David James, Vicky T Lam, Booil Jo, Lawrence K Fung","doi":"10.1155/bn/2951294","DOIUrl":"10.1155/bn/2951294","url":null,"abstract":"<p><p><b>Background:</b> Autism spectrum disorder (ASD) involves alterations in both cortical morphology and sensory processing. These structural and perceptual changes may lie on a continuum with typically developing (TD) individuals. However, investigations on possible links between these two factors are lacking, and it remains to be seen if their relationship differs by sex. We hypothesized that cortical thickness in the postcentral gyrus (a somatosensory processing hub) would correlate with sensory processing symptoms in a combined cohort of autistic and TD individuals. We also hypothesized that these correlations would differ based on sex. <b>Methods:</b> We studied 23 autistic adults and 27 TD adults using magnetic resonance imaging to measure the cortical thickness of the postcentral gyrus and the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) to measure autism characteristics, with a particular focus on the sensory motor subscale. <b>Results:</b> The left postcentral gyrus (PCG) was found to be thicker in the autism group than in the TD group (<i>d</i> = 0.946, <i>p</i> = 0.003), particularly in autistic males compared to TD males and TD females. The RAADS-R sensory motor subscale and bilateral PCG cortical thickness were positively correlated across both autistic and TD males (Spearman's rho = 0.481, <i>p</i> = 0.008) but not females. These correlations were specific to the sensory motor subscale, as no correlations were found for RAADS-R total score or any of the other subscales. <b>Conclusions:</b> These results demonstrate sex-specific differences in the relationship between cortical thickness at the PCG and sensory processing in autistic individuals and that these differences exist along a continuum that extends into the TD population. Our findings contribute to furthering our understanding of sex-specific neuroanatomical differences in people on the autism spectrum. The left PCG thickness could be a potential sex-specific biomarker for sensorimotor function that is generally applicable in both neurotypical and autism populations. With further validations, this biomarker could be used to track responses to interventions targeting sensorimotor challenges in people on the autism spectrum.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"2951294"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Public Knowledge, Attitudes, and Awareness Toward Seizure Episodes Among Residents of Madinah: A Saudi Cross-Sectional Study.","authors":"Bayan M Almarwani, Sadin Ayman Alamri, Aseel Ayman Alamri, Ahmad Salim Badawi, Zakaria Yahya Khawaji, Afnan Mohammad Akhwan, Basel MohammedBassam Garah, Abdullah A Tawakul","doi":"10.1155/bn/2142400","DOIUrl":"10.1155/bn/2142400","url":null,"abstract":"<p><p><b>Background:</b> Epilepsy is a prevalent condition that affects a large population. However, a lack of knowledge and misconceptions about seizures can lead to inappropriate reactions and negative attitudes toward people with epilepsy, who are more likely to experience stigma because of their illness. This study explored public knowledge, attitudes, and awareness of epilepsy and seizures among residents of Madinah, Saudi Arabia. <b>Methods:</b> A descriptive, cross-sectional study was conducted between September and November 2023 involving 2626 random adult residents of the Madinah Region in Saudi Arabia. Data were collected through an online survey consisting of 27 questions concerning epilepsy. <b>Results:</b> Regarding participants' awareness of epilepsy, 92.2% reported having heard or read about it, and 12.8% had attended a course on controlling epileptic seizures. The results showed an acceptable level of understanding about epilepsy. The mean knowledge and attitude scores about epilepsy for the sample were 22 (SD ± 3.2) and 27.1 (SD ± 3.1), respectively, indicating moderate knowledge and positive attitudes toward epilepsy. Among demographic characteristics, knowledge about epilepsy was significantly associated with gender, age, marital status, educational level, occupation, household monthly income, having heard about epilepsy, having a family member diagnosed with epilepsy, and course attendance. However, attitudes toward epilepsy were only significantly associated with gender, having heard about epilepsy, having a family member diagnosed with epilepsy, and course attendance. Similarly, actions toward seizure attacks were significantly associated with all demographic characteristics except education. <b>Conclusions:</b> The residents of Madinah have generally positive attitudes regarding epilepsy, although their knowledge levels could be enhanced by education. Therefore, more educational awareness campaigns are required to improve public understanding of epilepsy and appropriate actions to take when witnessing a seizure. The results of this study provide a foundation for worldwide comparisons of general levels of knowledge and attitudes concerning epilepsy in Saudi Arabia.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"2142400"},"PeriodicalIF":2.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Factors in Children With Status Epilepticus and Status Epilepticus Severity Score Scales.","authors":"Serap Bilge, Gülen Gül Mert, Özlem Hergüner, Faruk İncecik, Şakir Altunbaşak, Dinçer Yıldızdaş, Özden Özgür Horoz, Duygu Kuşcu","doi":"10.1155/bn/6660355","DOIUrl":"10.1155/bn/6660355","url":null,"abstract":"<p><p><b>Background:</b> According to the International League Against Epilepsy (ILAE) 2015 classification, status epilepticus (SE) is a seizure that lasts longer than 5 min or a frequency of more than one seizure within 5 min, without returning to a normal level of consciousness between episodes. In this study, we aimed to evaluate the prognostic factors of SE and compare our patients with those of patients treated internationally with the modified status epilepticus severity score (mSTESS) to determine the reliability of this scoring system. <b>Methods:</b> The medical records of patients aged 1 month-17 years with SE who were treated at Çukurova University-Balcalı Training and Research Hospital between September 2018 and September 2021 and who were followed in the intensive care unit were included in the study. <b>Results:</b> Seventy-two patients were included in this study. The mean age of the patients with SE was 5 years (3-8). The male/female ratio was 34 (47%)/38 (53%). A history of epilepsy was present in 53% of the patients. The most common etiologies behind SE were meningoencephalitis (19%), febrile status (8%), unknown status (12%), and genetic causes (7%). Comorbidities, including developmental delay/intellectual disability, cerebral palsy, hyperactivity, and autism spectrum disorder, were present in 44 (61%) of the patients. The cutoff was ≥ 2 for unfavorable outcomes and 4 for mortality in our patients according to the mSTESS system. The case mortality rate was 1% in our study. Nonconvulsive SE, slowing and abnormal ground on EEG, being stuporous or comatose, having abnormal MRI-CT, and having a comorbid condition were associated with an unfavorable prognosis in SE patients. <b>Conclusion:</b> The mSTESS is a useful and practical scoring system for predicting the prognosis of SE patients. Nonconvulsive SE, slowing and abnormal ground in EEG, being stuporous or comatose, abnormal MRI-CT, and the presence of comorbid conditions indicated poor prognosis of SE in children.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"6660355"},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}